WO2013005193A2 - Oxygénateur pour l'oxygénation d'un fluide organique dans un circuit extracorporel - Google Patents

Oxygénateur pour l'oxygénation d'un fluide organique dans un circuit extracorporel Download PDF

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Publication number
WO2013005193A2
WO2013005193A2 PCT/IB2012/053478 IB2012053478W WO2013005193A2 WO 2013005193 A2 WO2013005193 A2 WO 2013005193A2 IB 2012053478 W IB2012053478 W IB 2012053478W WO 2013005193 A2 WO2013005193 A2 WO 2013005193A2
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WO
WIPO (PCT)
Prior art keywords
oxygenator
oxygen
fluid
oxygenator according
dimensional frame
Prior art date
Application number
PCT/IB2012/053478
Other languages
English (en)
Other versions
WO2013005193A3 (fr
Inventor
Daniele Galavotti
Original Assignee
Rand S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rand S.R.L. filed Critical Rand S.R.L.
Publication of WO2013005193A2 publication Critical patent/WO2013005193A2/fr
Publication of WO2013005193A3 publication Critical patent/WO2013005193A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/28—Apparatus therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/025—Bobbin units
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/04—Hollow fibre modules comprising multiple hollow fibre assemblies
    • B01D63/043—Hollow fibre modules comprising multiple hollow fibre assemblies with separate tube sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2653—Degassing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2661—Addition of gas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/02—Specific tightening or locking mechanisms
    • B01D2313/025—Specific membrane holders

Definitions

  • the invention relates to an oxygenator for oxygenating an organic fluid, such as blood, as it flows in an extracorporeal circuit during treatment of a patient.
  • Disposable devices have been long known and used in the medical field, which can exchange a gas, such as oxygen, with an organic fluid, namely blood.
  • oxygenators These devices for exchanging oxygen with blood are simply known as oxygenators and are designed to release oxygen to blood and simultaneously remove excess carbon dioxide therefrom during extracorporeal circulation treatments.
  • Such gas exchanging unit typically consists of a multitude of so-called hollow fibers, which are substantially rectilinear and arranged in line with the longitudinal axis of the cylindrical body.
  • Each hollow fiber has an inlet lumen and an opposite outlet lumen, which are as large as a few hundreds of microns, and are formed of a flexible membrane, which is only gas- and not liquid-permeable.
  • the open ends of the hollow fibers are in turn incorporated and retained in two solid connection elements, known as "pottings", which are typically formed of polyurethane-based glued, and are used to hold the ends of the hollow fibers in a stable position, while keeping their inlet and outlet lumens clear.
  • pottings typically formed of polyurethane-based glued
  • the bodies of these oxygenators have a first pair of apertures, namely an inlet and an outlet for the fluid to be oxygenated, such as blood, the latter being forced to flow in the oxygenation chamber along a predetermined path defined therein, which forces it to lap the exterior of the hollow fibers in a flow direction substantially transverse thereto, thereby becoming richer in oxygen and releasing excess carbon dioxide.
  • the closing covers of both pottings fixed to the cylindrical body of the oxygenator have a second inlet and a second outlet, which are designed both for supplying oxygen gas, in pure form or diluted with other gases, such as nitrogen or air, and for discharging the carbon dioxide released to blood during oxygenation.
  • oxygenators are typically functionally or structurally combined with heat exchangers, which are required for temperature control of the blood flowing in the extracorporeal circuit of the patient to be treated, and which typically use water thermally treated by a heating or cooling device, to add or remove heat from patient's blood, and are generally known as “heaters” or “coolers” or otherwise generally defined as “temperature baths”.
  • the blood to be oxygenated that comes from the patient and is carried by a transport conduit shall enter the oxygenation chamber through the inlet therefor, lap the multitude of hollow fibers having oxygen, or a mixture of oxygen and other diluting gases, flowing therein, receive oxygen and simultaneously release carbon dioxide as a result of differential concentrations, and eventually flow out of the outlet in an oxygen-enriched state, to finally reach the patient through a return connection line.
  • Oxygen or the oxygen-containing gas mixture, enters its inlet and is released to blood while carbon dioxide is released by blood to the depleted oxygen that flows in the hollow fibers and is discharged through the outlet.
  • the blood flow that comes from the patient, passes through the oxygenator and goes back to the patient is typically generated and kept flowing using a pump mounted on the extracorporeal circuit, typically upstream from the oxygenator, in the section that connects the latter with the patient.
  • the pump action generates a pressure higher than atmospheric pressure in the oxygenator, which is sufficient to overcome the sum of mechanical resistances to blood flow, i.e. the resistances encountered by blood as it flows through the oxygenation chamber that contains the hollow fibers, and the internal resistances in the conduits that connect the various devices of the extracorporeal circuit with the peripheral circulatory system of the patient, to ensure that circulation is maintained active all along the path defined by the extracorporeal circuit.
  • optimized exchange surface area is intended to designate a surface that provides the maximum exchange volume relative to the overall surface area through which exchange occurs.
  • This patent provides an oxygenator that comprises a substantially cylindrical hollow box-like body that defines therein a blood treatment, i.e. blood oxygenation chamber, with an exchange unit arranged therein, comprising a plurality of diaphragms wrapped with bundle windings of a plurality of hollow fibers.
  • the box-like body has an inlet port for the blood to be oxygenated and an opposite outlet port for the oxygenated blood, which is parallel to the inlet port and defines therewith an alignment direction.
  • all the diaphragms are arranged parallel to the alignment direction and, as a result, the windings of hollow fibers are also arranged with their greater axes parallel to this direction.
  • the windings of hollow fibers have partition elements therebetween, which have the purpose of maintaining them separate and, like the diaphragms, have their longitudinal greater axes arranged parallel to the alignment direction.
  • Compartments are formed between the gas exchanging unit and the inner surface of the oxygenation chamber, a first compartment being designed to receive the inflowing blood to be oxygenated that enters through the inlet port, and a second opposite compartment receiving the oxygenated blood, that is designed to flow out through the outlet.
  • the body also has upper and lower closing covers that hermetically seal its ends and the compartments, the upper cover being designed to receive the oxygen that flows in the hollow fibers of the microporous capillary windings, and the lower cover being designed to receive the carbon dioxide accumulated after the exchange in the oxygenation chamber, once it is released from blood to the depleted oxygen flowing in the hollow fibers, typically due to differential concentration.
  • both the partition elements and the diaphragms wrapped with the microporous capillaries are substantially parallel and equally spaced.
  • each winding is held between two contiguous partition elements, or between an end partition and the inner surface of the oxygenation chamber of the container body, in the case of the lateral windings.
  • the windings of hollow fibers are introduced into the oxygenation chamber in substantially monolithic form, i.e. in a configuration in which the windings are bundled in a side-by-side arrangement, prepared beforehand.
  • the sizes of the interstices were found to be smaller in the areas closer to the outer surface of the bundle of windings, i.e. the ones closer to or in contact with the inner surface of the oxygenation chamber, as compared with those between the hollow fibers of the central areas, i.e. those closer to the diaphragms wrapped therewith.
  • This condition causes a problem that characterizes this kind of oxygenators, i.e. that, due to the difference of interstice sizes between the peripheral hollow fibers and the inner, central ones of the bundle of windings, the exchanging unit has areas in which the flow of organic flow is hindered and slowed down, and may be even stopped.
  • Another object of the invention is to provide an oxygenator for oxygenating an organic fluid in an extracorporeal circuit, that can provide an exchanging bundle allowing homogeneous flow therethrough over its entire surface, thereby preventing any stagnation danger.
  • Another object of the invention is to provide an oxygenator for oxygenating an organic fluid in an extracorporeal circuit, that has a construction allowing quick and easy assembly.
  • a further object of the invention is to provide an oxygenator for oxygenating an organic fluid in an extracorporeal circuit that only requires withdrawal of small amounts of blood from the patient, to be filled and operate properly.
  • Yet another object of the invention is to provide an oxygenator for oxygenating an organic fluid in an extracorporeal circuit that can also operate at very low pressures without the risk of creating stagnation areas and promoting turbulence of the flowing organic fluid, while preserving the integrity of both the cells that compose the organic fluid, in the case of blood, and the cell membranes of the red blood cells, by minimizing the shear stresses that cause hemolysis.
  • Another object of the invention is to provide an oxygenator for oxygenating an organic fluid in an extracorporeal circuit that can adequately and consistently oxygenate the flow of organic fluid that passes through it during use and for the whole life of the device, in spite of progressive and inevitable ageing and degradation of the materials of which it is formed.
  • the invention provides an oxygenator for oxygenating an organic fluid in an extracorporeal circuit as defined in claim 1 .
  • the position of the exchanging unit in the oxygenation chamber provides an arrangement of contact areas having predetermined patterns of concave and convex surfaces, for overall improvement of gas exchange between the oxygen that flows in the microporous capillaries, i.e. the hollow fibers, and the blood that laps the outer surface of such capillaries.
  • providing an oxygenator device can be easily coupled both with a heat exchanger, that does not require the use of a temperature-controlling liquid and with a heat exchanger that uses a temperature-controlling liquid.
  • FIG. 1 is a perspective view of an oxygenator for oxygenating an organic fluid in an extracorporeal circuit according to the invention ;
  • FIG. 2 is a perspective view of the oxygenator of Figure 1 , with the upper portion being omitted to provide a partial view of its interior during one of the temporary mounting/assembly steps;
  • FIG. 3 is an exploded perspective view of the oxygenator of Figure 1 ;
  • FIG. 4 is an exploded view of the components of a gas exchanging unit of the oxygenator of the invention ;
  • FIG. 5 is a cross-sectional view of the oxygenator of the invention, as taken along a plane V-V of Fig. 1 ;
  • FIG. 6 is a broken and slightly enlarged view of a portion of the sectional view of Figure 5;
  • FIG. 7 is a perspective view of a three-dimensional frame that forms the gas exchanging unit of the oxygenator of the invention ;
  • FIG. 8 is a perspective, highly enlarged view of a diaphragm which is designed to be wrapped with a bundle of hollow fibers to create a winding ;
  • FIG. 9 is a top view of the oxygenator of the invention .
  • FIG. 10 is a vertical sectional view of the oxygenator of the invention, as taken along a plane X-X of Figure 9;
  • FIG. 1 1 is a highly enlarged view of a winding of hollow fibers accommodated in a compartment within the oxygenation chamber of the oxygenator of the invention.
  • an oxygenator for oxygenating an organic fluid in an extracorporeal circuit is generally referenced 1 and includes a box-like body 2 substantially having the shape of a parallelepiped with rounded edges and in which an oxygenation chamber 3 is defined for oxygenating the organic fluid to be oxygenated which, in the following description is by way of example and without limitation blood.
  • An exchanging unit is arranged in the oxygenation chamber 3, and comprises a plurality of flat diaphragms 5, wrapped with a plurality of hollow fibers, referenced 6, in bundle winding form.
  • the box-like body 2 has a series of outer stiffening ribs 1 02, an inlet port 7 for the blood to be treated and an opposite outlet port 8, which is aligned with the inlet port 7.
  • the exchanging unit 4 also comprises a three-dimensional frame 9 which is preferably formed of one piece and is designed to be inserted in the oxygenation chamber 3.
  • This frame 9 forms a plurality of ribs 1 0, or partition elements, which are parallel to one another and to the alignment direction "DA" and are transversely joined by perforated walls 1 1 which form a mesh grid through which blood may flow to lap the hollow fibers 6.
  • innermost compartments 1 2 are defined between contiguous ribs, which are designed to receive respective windings of hollow ribs 6 therein.
  • the perforated walls 1 1 are discontinued in their longitudinal direction to abut against the inner end walls of the oxygenation chamber 3 to form therewith two additional end compartments 1 2 for receiving two additional windings of hollow fibers 6, having substantially the same size as the innermost compartments 1 2.
  • the chamber 1 3 is designed to be used for accumulation of the inflowing blood that has just entered through the inlet port 7 and is waiting to be oxygenated, whereas the chamber 14 is designed to be used for accumulation of the blood that, after flowing through the windings of hollow fibers 6 and being oxygenated and washed out of excess carbon dioxide, is ready to flow out of the outlet port 8 to reach back the patient.
  • lumens referenced 1 5, 1 6, 1 7, are also formed in the body 2 for connecting the oxygenation chamber 3 with the outside environment, for exhausting any air contained in blood, both before and after oxygenation.
  • the body 2 comprises two end covers, an upper cover 1 8 and a lower cover 1 9 which, with the oxygenator 1 in the assembled state, are fixed to the ends of the oxygenation chamber 3, with seals 20 and 21 interposed therebetween.
  • Both covers 1 8 and 1 9 have additional lumens 22 and 23.
  • the lumen 22 may be designed for introduction of oxygen or the mixture of oxygen and other gases, whereas the lumen 23 may be designed for removal of the carbon dioxide washed out of blood during oxygenation.
  • two additional collection chambers 24 and 25 are defined between the covers 1 8 and 1 9 and the exchanging unit 4, with the chamber 24 being used for accumulation of oxygen or the mixture of oxygen and other gases, that has to longitudinally flow through the windings of hollow fibers 6.
  • the potting 26 is shown with an inclination of its surface toward the interior of the box-like body 2 for gradually conveying any microbubbles in the oxygenator towards the special debubbling outlets 1 5, 16 or 1 7 through the narrow chambers 13 and 14.
  • each rib 1 0 the ends 1 1 0 extending in the alignment direction "DA" are enlarged and each defines a respective longitudinal rib 21 0 in the perforated walls 1 1 , from which spacing buttons 29 extend, which are designed to lie against the inner surface of the oxygenation chamber 3, to hold the frame 9 in a firm centered position.
  • a diaphragm 5 which comprises a substantially sheet-like body 1 05 having the two opposed larger edges shaped to form a series of raised directional baffles 205.
  • These directional baffles 205 are designed to impart a wavy motion to the blood flow that laps them and laps the surfaces of the diaphragm 5, as shown by way of illustration only by broken arrows "FL".
  • the baffles on one side are intentionally not aligned with the baffles of the other side, to prevent the formation of laminar, non-wavy blood flows between the two sides.
  • the surfaces of the diaphragms 5 have slightly concave profiles in the longitudinal direction, as shown when looking at the ends of the diaphragm as shown in Figure 8, in which two opposed concavities "C1 " and “C2" of the two surfaces are found between two projecting teeth 305, that are designed to be embedded in the pottings 26 and 27 of the oxygenator 1 .
  • these concavities are located at transverse enlargements 310 formed in the center areas of the ribs 1 0.
  • the winding of hollow fibers 6 is found to have, in cross sectional view, two end areas 1 06 in which the compression of the hollow fibers 6, designated by the arrows "CP" is slightly greater than the compression at the median areas 206 interposed between the end areas 1 06.
  • the operation of the oxygenator of the invention is substantially similar to the operation of a prior art oxygenator.
  • the oxygenator 1 is introduced into an extracorporeal circuit for oxygenating an organic fluid, namely for oxygenating the blood of a patient.
  • Blood fills the oxygenation chamber 3 and flows through the perforated walls 1 1 of the three-dimensional frame 9, whereupon it tangentially laps the windings of hollow fibers 6 in which oxygen, or an oxygen mixture, flows, after entering the lumen 22, accumulating in the collection chamber 24 and flowing through the hollow fibers, whereby gas is exchanged with blood, due to differential concentration.
  • the oxygenated blood collects in the chamber 14 formed by the inner wall of the oxygenation chamber 3 and the three-dimensional frame 9 and is conveyed back to the patient through the outlet port 8.
  • Blood is kept flowing by a known type of pump unit, mounted to the extracorporeal circuit. Any air bubble in blood is vented out of the oxygenator through the lumens 15, 1 6, 1 7, to prevent them from accidentally reaching the patient.
  • Gas exchange between the hollow fibers 6 and blood is substantially complete and homogeneous over the entire available surface of the windings of hollow fibers 6, because the fibers in the areas of the oxygenator 1 close to the walls of the oxygenation chamber or the areas of the compartments 12 defined in the three-dimensional frame 9 have a controlled peripheral compression, which is maintained by the stiffness of the three-dimensional frame 9.
  • the profiles of the diaphragms 5 and the baffles 205 impart a wavy motion to blood flows, to avoid any laminar flow and promote turbulent flow, thereby improving contact with the surfaces of the hollow fibers 6 and, as a result, gas exchange.
  • the oxygenator 1 of the invention can be assembled in a particularly quick and easy manner.
  • the windings of hollow fibers 6 are prepared and introduced into the compartments 1 2 defined in the three-dimensional frame 9 and between the end walls 1 1 of the latter and the inner walls of the oxygenation chamber 3.
  • the three-dimensional frame 9, with its windings of hollow fibers 6 is placed in the oxygenation chamber 3 with the spacing buttons 29 holding it in the proper position.
  • compartments 1 2 are substantially non-deformable and prevent undesired crushing of the windings of hollow fibers 6.
  • the two end pottings are formed and the covers 18 and 1 9 are placed, with the interposition of respective seals 20 and 21 .
  • the skilled person may change the number of compartments 12 of the three-dimensional frame 9 according to special requirements and blood volumes to be oxygenated: therefore, the oxygenator 1 may have dimensional configurations designed for adult patients or for pediatric or infant use.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Water Supply & Treatment (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

Oxygénateur (1) destiné à oxygéner le sang lors de la circulation extracorporelle, comprenant un corps (2) en forme de boîte dans lequel est définie une chambre d'oxygénation (3) dotée d'une entrée (7) pour le fluide organique à oxygéner, et d'une sortie (8) pour le fluide organique oxygéné, au moins une unité d'échange d'oxygène (4) pour l'échange d'oxygène avec ledit fluide organique, qui est installée dans ladite chambre d'oxygénation (3) et qui comprend au moins deux enroulements de fibres creuses (6) constituées d'une membrane microporeuse perméable aux gaz, destinées à être recouvertes par des flux transversaux dudit fluide à oxygéner, et à travers lesquelles passe l'oxygène ou le mélange d'oxygène, ledit oxygénateur comprenant au moins une structure tridimensionnelle (9) conçue pour être placée à l'intérieur de ladite chambre d'oxygénation (3) et définissant au moins deux compartiments formant logement (1, 2) correspondants dans lesquels lesdits au moins deux enroulement (6) sont logés dans un état comprimé périphériquement.
PCT/IB2012/053478 2011-07-06 2012-07-06 Oxygénateur pour l'oxygénation d'un fluide organique dans un circuit extracorporel WO2013005193A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000166A ITMO20110166A1 (it) 2011-07-06 2011-07-06 Un ossigenatore per ossigenare un fluido organico in un circuito extracorporeo
ITMO2011A000166 2011-07-06

Publications (2)

Publication Number Publication Date
WO2013005193A2 true WO2013005193A2 (fr) 2013-01-10
WO2013005193A3 WO2013005193A3 (fr) 2013-03-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/053478 WO2013005193A2 (fr) 2011-07-06 2012-07-06 Oxygénateur pour l'oxygénation d'un fluide organique dans un circuit extracorporel

Country Status (2)

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IT (1) ITMO20110166A1 (fr)
WO (1) WO2013005193A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113599605A (zh) * 2021-07-29 2021-11-05 深圳汉诺医疗科技有限公司 一种膜式氧合器
US11980705B2 (en) 2018-03-02 2024-05-14 Spectrum Medical Ltd. Oxygenation system

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5739854A (en) * 1980-08-25 1982-03-05 Terumo Corp Hollow fiber type artificial lung building in heat exchanger
US4639353A (en) * 1984-04-24 1987-01-27 Mitsubishi Rayon Co., Ltd. Blood oxygenator using a hollow-fiber membrane
US4808378A (en) * 1985-11-11 1989-02-28 Senko Medical Instrument Mfg. Co., Ltd. Blood oxygenator
ITMO20040012A1 (it) * 2004-01-20 2004-04-20 Rand Srl Dispositivo per il trattamento di sangue per la circolazione extracorporea
IT1394992B1 (it) * 2009-07-28 2012-08-07 Rand Srl Dispositivo ossigenatore

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11980705B2 (en) 2018-03-02 2024-05-14 Spectrum Medical Ltd. Oxygenation system
CN113599605A (zh) * 2021-07-29 2021-11-05 深圳汉诺医疗科技有限公司 一种膜式氧合器
CN113599605B (zh) * 2021-07-29 2024-02-20 深圳汉诺医疗科技有限公司 一种膜式氧合器

Also Published As

Publication number Publication date
WO2013005193A3 (fr) 2013-03-07
ITMO20110166A1 (it) 2013-01-07

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