WO2013000910A1 - Mousse de liaison pour des pansements - Google Patents

Mousse de liaison pour des pansements Download PDF

Info

Publication number
WO2013000910A1
WO2013000910A1 PCT/EP2012/062355 EP2012062355W WO2013000910A1 WO 2013000910 A1 WO2013000910 A1 WO 2013000910A1 EP 2012062355 W EP2012062355 W EP 2012062355W WO 2013000910 A1 WO2013000910 A1 WO 2013000910A1
Authority
WO
WIPO (PCT)
Prior art keywords
isocyanate
mol
foam
polyurethane
optionally
Prior art date
Application number
PCT/EP2012/062355
Other languages
German (de)
English (en)
Inventor
Meike Niesten
Sebastian Dörr
Sascha Plug
Original Assignee
Bayer Intellectual Property Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Intellectual Property Gmbh filed Critical Bayer Intellectual Property Gmbh
Publication of WO2013000910A1 publication Critical patent/WO2013000910A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/30—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by mixing gases into liquid compositions or plastisols, e.g. frothing with air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/18—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by features of a layer of foamed material
    • B32B5/20—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by features of a layer of foamed material foamed in situ
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/22—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed
    • B32B5/32—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed at least two layers being foamed and next to each other
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/0804—Manufacture of polymers containing ionic or ionogenic groups
    • C08G18/0819—Manufacture of polymers containing ionic or ionogenic groups containing anionic or anionogenic groups
    • C08G18/0823—Manufacture of polymers containing ionic or ionogenic groups containing anionic or anionogenic groups containing carboxylate salt groups or groups forming them
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/0804—Manufacture of polymers containing ionic or ionogenic groups
    • C08G18/0819—Manufacture of polymers containing ionic or ionogenic groups containing anionic or anionogenic groups
    • C08G18/0828—Manufacture of polymers containing ionic or ionogenic groups containing anionic or anionogenic groups containing sulfonate groups or groups forming them
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C08G18/12—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/2805—Compounds having only one group containing active hydrogen
    • C08G18/2815—Monohydroxy compounds
    • C08G18/283—Compounds containing ether groups, e.g. oxyalkylated monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/4009—Two or more macromolecular compounds not provided for in one single group of groups C08G18/42 - C08G18/64
    • C08G18/4018—Mixtures of compounds of group C08G18/42 with compounds of group C08G18/48
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/44—Polycarbonates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C08G18/4837—Polyethers containing oxyethylene units and other oxyalkylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4854—Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/721—Two or more polyisocyanates not provided for in one single group C08G18/73 - C08G18/80
    • C08G18/722—Combination of two or more aliphatic and/or cycloaliphatic polyisocyanates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/77—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur
    • C08G18/78—Nitrogen
    • C08G18/79—Nitrogen characterised by the polyisocyanates used, these having groups formed by oligomerisation of isocyanates or isothiocyanates
    • C08G18/791—Nitrogen characterised by the polyisocyanates used, these having groups formed by oligomerisation of isocyanates or isothiocyanates containing isocyanurate groups
    • C08G18/792—Nitrogen characterised by the polyisocyanates used, these having groups formed by oligomerisation of isocyanates or isothiocyanates containing isocyanurate groups formed by oligomerisation of aliphatic and/or cycloaliphatic isocyanates or isothiocyanates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/36—After-treatment
    • C08J9/365—Coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/02—2 layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/22—All layers being foamed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2266/00—Composition of foam
    • B32B2266/02—Organic
    • B32B2266/0214—Materials belonging to B32B27/00
    • B32B2266/0278—Polyurethane
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2266/00—Composition of foam
    • B32B2266/06—Open cell foam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2305/00—Condition, form or state of the layers or laminate
    • B32B2305/02—Cellular or porous
    • B32B2305/022—Foam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2305/00—Condition, form or state of the layers or laminate
    • B32B2305/02—Cellular or porous
    • B32B2305/026—Porous
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2305/00—Condition, form or state of the layers or laminate
    • B32B2305/77—Uncured, e.g. green
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/72—Density
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/726—Permeability to liquids, absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/728—Hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2556/00—Patches, e.g. medical patches, repair patches
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2101/00—Manufacture of cellular products
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
    • C08J2375/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2475/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers

Definitions

  • the present invention relates to a composite foam comprising an absorption layer and a storage layer connected at least in regions to the absorption layer. Further objects of the invention are a process for producing the composite foam according to the invention and a wound dressing comprising the composite foam according to the invention.
  • European Patent Application EP 2 143 744 A1 describes hydrophilic aliphatic polyurethane foams which are obtainable by reacting monomer-poor prepolymers with water.
  • the absorbency of these foams for liquids such as water is high, i. they can store large quantities of liquid, but the absorption rate is relatively low, so that only relatively small amounts of liquid per time can be absorbed.
  • This is disadvantageous for sanitary napkins, diapers or wound dressings, since it is of decisive importance here that the liquid is absorbed quickly and transported away from the receiving location into the interior of the foam. This is especially true in the treatment of open wounds such as ulcers during the exudative phase of wound healing. In this case, the excess moisture released by the wound must be absorbed, otherwise a secretion may cause a wound infection.
  • EP 2 028 223 A1 again discloses polyurethane foams which can be produced by mechanical foaming of aqueous polyurethane dispersions. These foams are intended, inter alia, for use in wound dressings and are characterized by a high absorption rate for liquids. However, their absorption capacity is limited.
  • EP 2 140 888 A1 discloses a composite foam which can be used in particular as part of a wound dressing.
  • the composite foam comprises a storage layer, an absorption layer and a cover layer.
  • the storage layer consists of a superabsorbent and the absorption layer of a polyurethane foam, which is obtained by mechanical impact of an aqueous polyurethane dispersion.
  • the composite foam is an island composite in which the storage layer is completely enclosed by the absorption layer and the cover layer.
  • the composite foam is produced by applying the polyurethane foam of the absorption layer to a substrate and using a superabsorbent material. bervlies is placed in the still wet foam.
  • the cover layer is then applied to the absorption layer over the superabsorbent web.
  • a further polyurethane foam or a thermoplastic film can be used as the cover layer, which are then bonded to the absorption layer either by drying the polyurethane foam or by thermolamination of the thermoplastic film.
  • Composite foams for wound dressings without a cover layer are not disclosed in EP 2 140 888 A1.
  • the top layer is also required because the superabsorbent fleece on the one hand on the access of liquid from the outside must be protected and on the other hand its direct contact with tissue, such as by accidental contact, should be prevented. For this reason, the design options with respect to the spatial arrangement and connection of the individual layers are limited in the known composite foam.
  • Another disadvantage of this composite foam is the extremely high absorption capacity of the superabsorbent, which can cause excessive drying of the wound, although a slightly moist environment of fresh wound exudate is optimal for wound healing.
  • the object of the present invention was therefore to provide a composite foam which has a high absorbency and a high absorption rate while allowing great flexibility in the arrangement and connection of the individual layers.
  • a composite foam comprising an absorption layer and a storage layer connected at least in regions directly to the absorption layer, in which the absorption layer comprises a polyurethane foam A) which is obtainable by mechanical foaming of an aqueous polyurethane dispersion a) and subsequent drying and the storage layer comprises a polyurethane foam B) obtainable by reacting at least the following components: b) an isocyanate-functional prepolymer, c) water.
  • the composite foam according to the invention is both capable of quickly absorbing liquids such as water and of storing them in large quantities. It thus has both a high absorption rate and a high absorption capacity, the absorption capacity is not so great that it when used in a wound dressing can lead to excessive drying of the wound.
  • the absorption layer and the storage layer can be spatially arranged in a variety of ways and directly connected to each other, wherein it additionally does not necessarily require an additional cover layer.
  • the direct connection of the absorption layer with the storage layer the transfer of liquids from the absorption layer into the storage layer takes place particularly efficiently. This advantage is particularly evident in comparison with prior art composite foams in which the absorption layer and the storage layer are connected, for example, by an adhesive between the layers. Thus, the adhesive may interfere with the transfer of fluid between the layers.
  • the polyurethane dispersion a) is obtainable by reacting at least the following components: a) an isocyanate-functional prepolymer, a2) optionally an isocyanate-reactive, preferably amino-functional, anionic or potentially anionic hydrophobic agent, a3) optionally an amino-functional compound, in particular having a molecular weight of from 32 to 400 g / mol, a4) water, wherein the hydrophobic agent a2) is obligatory if the prepolymer al) itself does not have any hydrophilicizing groups.
  • polyurethane foams which are obtainable by foaming such an aqueous polyurethane dispersion, are distinguished by a particularly high absorption rate.
  • an isocyanate-functional prepolymer al obtainable by reacting at least the following components: aa) an organic polyisocyanate, aa2) a polymeric polyol, in particular having a number-average molecular weight of 400 to 8000 g / mol and / or an average OH functionality of 1.5 to 6, aa3) optionally a hydroxy-functional compound, in particular having a molecular weight of 62 to 399 g / mol, aa4) optionally an isocyanate-reactive, anionic or potentially anionic and / or optionally nonionic hydrophilicizing agent.
  • Suitable polyisocyanates of component aal) are the aromatic, araliphatic, aliphatic or cycloaliphatic polyisocyanates having an NCO functionality of> 2 known to the person skilled in the art.
  • Examples of such polyisocyanates are 1,4-butylene diisocyanate, 1,6-hexamethylene diisocyanate
  • HDI isophorone diisocyanate
  • IPDI isophorone diisocyanate
  • 2,2,4 and / or 2,4,4-trimethylhexamethylene diisocyanate the isomeric bis (4,4'-isocyanatocyclohexyl) methanes or mixtures thereof of any isomer content, 1,4-cyclohexylene diisocyanate, 1 , 4-phenylene diisocyanate, 2,4- and / or 2,6-toluene diisocyanate, 1,5-naphthylene diisocyanate, 2,2'- and / or 2,4'- and / or 4,4'-di-phenylmethane diisocyanate, 1 , 3- and / or 1,4-bis (2-isocyanato-prop-2-yl) -benzene (TMXDI), 1,3-bis (isocyanatomethyl) benzene (XDI), alkyl 2,6-diisocyan
  • modified diisocyanates or triisocyanates having uretdione, isocyanurate, urethane, allophanate, biuret, iminooxadiazinedione and / or oxadiazinetrione structures.
  • polyisocyanates or polyisocyanate mixtures of the abovementioned type with exclusively aliphatically and / or cycloaliphatically bonded isocyanate groups and an average NCO functionality of the mixture of 2 to 4, preferably 2 to 2.6 and particularly preferably 2 to 2.4 ,
  • polymeric polyols having a number average molecular weight Mn of from 400 to 8000 g / mol and more preferably from 600 to 3000 g / mol. These preferably have an OH functionality of from 1.8 to 3, particularly preferably from 1.9 to 2.1.
  • Suitable polymeric polyols are the polyester polyols known per se in polyurethane coating technology, polyacrylate polyols, polyurethane polyols, polycarbonate polyols, polyether polyols, polyester polyacrylate polyols, polyurethane polyacrylate polyols, polyurethane polyester polyols, polyurethane polyether polyols, polyurethane polycarbonate polyols and polyester polycarbonate polyols. These can be used in aa2) individually or in any mixtures with each other.
  • polyester polyols examples include the known polycondensates of di- and optionally tri- and tetraols and di- and optionally tri- and tetracarboxylic acids or hydroxycarboxylic acids or lactones. Instead of the free polycarboxylic acids, it is also possible to use the corresponding polycarboxylic acid anhydrides or corresponding polycarboxylic acid esters of lower alcohols to prepare the polyesters.
  • Suitable diols for the preparation are ethylene glycol, butylene glycol, diethylene glycol, triethylene glycol, polyalkylene glycols such as polyethylene glycol, furthermore 1,2-propanediol, 1,3-propanediol, butanediol (1,3), butanediol (1,4), hexanediol (1,6 and isomers, neopentyl glycol or hydroxypivalic acid neopentyl glycol esters, with hexanediol (1,6) and isomers, neopentyl glycol and neopentyl glycol hydroxypivalate being preferred.
  • polyalkylene glycols such as polyethylene glycol, furthermore 1,2-propanediol, 1,3-propanediol, butanediol (1,3), butanediol (1,4), hexanediol (1,6 and
  • polyols such as trimethylolpropane, glycerol, erythritol, pentaerythritol, trimethylolbenzene or trishydroxyethyl isocyanurate.
  • Suitable dicarboxylic acids are phthalic acid, isophthalic acid, terephthalic acid, tetrahydrophthalic acid, hexahydrophthalic acid, cyclohexanedicarboxylic acid, adipic acid, azelaic acid, sebacic acid, glutaric acid, tetrachlorophthalic acid, maleic acid, fumaric acid, itaconic acid, malonic acid, suberic acid, 2-methylsuccinic acid, 3,3-diethylglutaric acid and / or 2,2-dimethylsuccinic acid.
  • the acid source used may also be the corresponding anhydrides.
  • monocarboxylic acids such as benzoic acid and hexanecarboxylic acid may additionally be used.
  • Preferred acids are aliphatic or aromatic acids of the abovementioned type. Particular preference is given to adipic acid, isophthalic acid and, if appropriate, trimellitic acid.
  • Hydroxycarboxylic acids which can be used as reactants in the preparation of a hydroxyl-terminated polyester polyol include hydroxycaproic acid, hydroxybutyric acid, hydroxydecanoic acid, hydroxystearic acid and the like.
  • Suitable lactones are caprolactone, butyrolactone and homologs. Preference is given to caprolactone.
  • hydroxyl-containing polycarbonates preferably polycarbonatediols, particularly preferably having number-average molecular weights M n of from 400 to 8000 g / mol and very particularly preferably from 600 to 3000 g / mol.
  • carbonic acid derivatives such as diphenyl carbonate, dimethyl carbonate or phosgene
  • Suitable diols are ethylene glycol, 1, 2 and 1, 3-propanediol, 1,3- and 1, 4-butanediol, 1,6-hexanediol, 1,8-octanediol, neopentyl glycol, 1, 4-bishydroxymethylcyclohexane, 2 Methyl-1,3-propanediol, 2,2,4-trimethylpentanediol-1,3-dipropylene glycol, polypropylene glycols, dibutylene glycol, polybutylene glycols, bisphenol A and lactone-modified diols of the abovementioned type.
  • the polycarbonate diol preferably contains from 40 to 100% by weight. % Hexane diol, especially 1,6-
  • Hexanediol and / or hexanediol derivatives based on the underlying diols. These hexanediol derivatives are based on hexanediol and have ester or ether groups in addition to terminal OH groups. Such derivatives are obtainable by reaction of hexanediol with excess caprolactone or by etherification of hexanediol with itself to give di- or trihexylene glycol.
  • polyether-polycarbonate diols instead of or in addition to pure polycarbonate diols, it is also possible to use polyether-polycarbonate diols in aa2).
  • the hydroxyl-containing polycarbonates are preferably built linear.
  • polyether polyols can be used.
  • Suitable examples are the polytetramethylene glycol polyethers known per se in polyurethane chemistry, such as are obtainable by polymerization of tetrahydrofuran by means of cationic ring opening.
  • suitable polyether polyols are the per se known addition products of styrene oxide, ethylene oxide, propylene oxide, butylene oxides and / or epichlorohydrin to di- or polyfunctional starter molecules.
  • suitable starter molecules it is possible to use all known compounds according to the prior art. These are, for example, water, butyldiglycol, glycerol, diethylene glycol, trimethylolpropane, propylene glycol, sorbitol, ethylenediamine, triethanolamine, 1,4-butanediol.
  • Preferred starter molecules are water, ethylene glycol, propylene glycol, 1,4-butanediol, diethylene glycol and butyl diglycol.
  • Particularly preferred components aa2) used are a mixture of polycarbonate polyols and polytetramethylene glycol polyols, in which mixture the proportion of polycarbonate polyols may preferably be from 20 to 80% by weight and the proportion of polytetramethylene glycol polyols may preferably be from 80 to 20% by weight. More preferred is a proportion of 30 to 75 wt .-% of polytetramethylene glycol polyols and a proportion of 25 to 70 wt .-% of polycarbonate polyols.
  • a3) may optionally hydroxy-functional compounds such as polyols of said molecular weight range having up to 20 carbon atoms, such as ethylene glycol, diethylene glycol, triethylene glycol, 1, 2-propanediol, 1,3-propanediol, 1, 4-butanediol, 1,3-butylene glycol, cyclohexanediol , 1,4-cyclohexanedimethanol, 1,6-hexanediol, neopentyl glycol, hydroquinone dihydroxyethyl ether, bisphenol A (2,2-bis (4-hydroxyphenyl) propane), hydrogenated bisphenol A, (2,2-bis (4-hydroxycyclohexyl) propane), trimethylolpropane, glycerol, pentaerythritol and any mixtures thereof.
  • polyols of said molecular weight range having up to 20 carbon atoms such as ethylene glycol, diethylene glycol, triethylene glyco
  • ester diols of the stated molecular weight range, such as ⁇ -hydroxybutyl- ⁇ -hydroxycaproic acid ester, ro-hydroxyhexyl- ⁇ -hydroxybutyric acid ester, adipic acid- ( ⁇ -hydroxyethyl) ester or terephthalic acid bis ( ⁇ -hydroxyethyl) ester.
  • monofunctional, hydroxyl-containing compounds in aa3).
  • monofunctional compounds are ethanol, n-butanol, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, ethylene glycol monobutyl ether, diethylene glycol monobutyl ether, propylene glycol monomethyl ether,
  • Particularly preferred compounds of component aa3) are 1,6-hexanediol. 1, 4-butanediol, neopentyl glycol and trimethylolpropane.
  • anionically or potentially anionically hydrophilizing compounds of component aa4) is meant all compounds which have at least one isocyanate-reactive group such as a hydroxyl group and at least one functionality such as -COCTM + , -SO3 M + , -PO (OTVI + ) 2 with M + for example, metal cation, H + , NH 4 + , NHR 3 + , where R may each be a C 1 -C 12 -alkyl radical, C 5 -C 6 -cycloalkyl radical and / or a C 2 -C 4 -hydroxyalkyl radical which, upon interaction with aqueous media, has a pH - Value-dependent dissociation equilibrium is received and can be loaded in this way negative or neutral.
  • Suitable anionic or potentially anionic hydrophilizing compounds are mono- and dihydroxycarboxylic acids, mono- and dihydroxysulfonic acids, as well as mono- and dihydroxyphosphonic acids and their salts.
  • Examples of such anionic or potentially anionic hydrophobic agents are dimethylolpropionic acid, dimethylolbutyric acid, hydroxypivalic acid, malic acid, citric acid, glycolic acid, lactic acid and the propoxylated adduct of 2-butenediol and NaHSOs, as described in DE-A 2 446 440, page 5-9, Formula I-III is described.
  • Preferred anionic or potentially anionic hydrophobic agents of component aa4) are those of the abovementioned type which have carboxylate or carboxylic acid groups and / or sulfonate groups.
  • anionic or potentially anionic hydrophobic agents of component aa4) are those which contain carboxylate or carboxylic acid groups as ionic or potentially ionic groups, such as dimethylolpropionic acid, dimethylolbutyric acid and hydroxypivalic acid or salts thereof.
  • Suitable nonionically hydrophilicizing compounds of component aa4) are e.g. Polyoxyalkylenether containing at least one hydroxy or amino group, preferably at least one hydroxy group.
  • Examples are the monohydroxy-functional, on average 5 to 70, preferably 7 to 55 ethylene oxide units per molecule having Polyalkylenoxidpolyetheralkohole, as they are accessible in a conventional manner by alkoxylation of suitable starter molecules (eg in Ullmann's Encyclopedia of Industrial Chemistry, 4th Edition, Volume 19, Verlag Chemie, Weinheim pp. 31-38).
  • These compounds are either pure polyethylene oxide ethers or mixed polyalkyleneoxides, in which case they then preferably contain at least 30 mol% and more preferably at least 40 mol%, based on all the alkylene oxide units present, of ethylene oxide units.
  • Very particularly preferred nonionic compounds are monofunctional mixed polyalkylene oxide polyethers which have 40 to 100 mol% of ethylene oxide and 0 to 60 mol% of> propylene oxide units.
  • Suitable starter molecules for such nonionic hydrophilicizing agents are saturated monoalcohols, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-
  • Butanol the isomers pentanols, hexanols, octanols and nonanols, n-decanol, n-dodecanol, n-tetradecanol, n-hexadecanol, n-octadecanol, cyclohexanol, the isomeric methylcyclohexanols or hydroxymethylcyclohexane, 3-ethyl-3-hydroxymethyloxetane or Tetrahydrofurfuryl alcohol, diethylene glycol monoalkyl ethers such as diethylene glycol monobutyl ether, unsaturated alcohols such as allyl alcohol, 1,1-dimethylallyl alcohol or oleic alcohol, aromatic alcohols such as phenol, the isomeric cresols or methoxyphenols, araliphatic alcohols such as benzyl alcohol, anisalcohol or cinnamyl alcohol, secondary mono
  • Alkylene oxides which are suitable for the alkoxylation reaction are, in particular, ethylene oxide and propylene oxide, which can be used in any desired order or even as a mixture in the alkoxylation reaction.
  • the molar ratio of isocyanate groups to isocyanate-reactive groups may be 1.05 to 3.5, preferably 1.2 to 3.0, particularly preferably 1.3 to 2.5.
  • the reaction of components aal) to aa44) to the prepolymer takes place partially or completely, but preferably completely. In this way, polyurethane prepolymers which contain free isocyanate groups are obtained in bulk or in solution.
  • bases such as tertiary amines, e.g. Trialkylamines having 1 to 12, preferably 1 to 6 carbon atoms, particularly preferably 2 to 3 carbon atoms in each alkyl radical or alkali metal bases used as the corresponding hydroxides.
  • alkyl radicals can also carry, for example, hydroxyl groups, as in the case of the dialkylmonoalkanol, alkyldialkanol and trialkanolamines.
  • inorganic bases such as aqueous ammonia solution or sodium or potassium hydroxide can also be used as neutralizing agents.
  • ammonia triethylamine, triethanolamine, dimethylethanolamine or diisopropylethylamine and also sodium hydroxide and potassium hydroxide, particular preference to sodium hydroxide and potassium hydroxide.
  • the molar amount of the bases is in particular 50 and 125 mol%, preferably between 70 and 100 mol% of the molar amount of the acid groups to be neutralized.
  • the neutralization can also take place simultaneously with the dispersion in which the dispersing water already contains the neutralizing agent.
  • Isocyanate-reactive, anionic or potentially anionic hydrophilicizing agents a2) are understood as meaning all compounds which have at least one isocyanate-reactive group, preferably an amino group, and at least one hydrophilizing group such as -COO M + , -SO 3 TVT, -PO (OTVI + ) 2 with M +, for example, the same metal cation, H + , NH 4 + , NHR 3 + , where R may each be a C 1 -C 12 -alkyl radical, C 5 -C 6 -cycloalkyl radical and / or a C 2 -C 4 -hydroxyalkyl radical which may be present at Interaction with aqueous media, a pH value dependent dissociation equilibrium is received and can be charged in this way negative or neutral.
  • Suitable compounds a2) are mono- and diaminocarboxylic acids, mono- and diaminosulfonic acids and also mono- and diaminophosphonic acids and their salts.
  • anionic or potentially anionic hydrophilicizing agents are N- (2-aminoethyl) - ⁇ -alanine, 2-
  • Preferred hydrophilicizing agents a2) are those of the abovementioned type which have carboxylate or carobonic acid groups and / or sulfonate groups such as the salts of N- (2-aminoethyl) - ⁇ -alanine, of 2- (2-aminoethylamino) ethanesulfonic acid or of Addition product of IPDA and acrylic acid (EP-A 0 916 647, Example 1).
  • Hydrophilic and nonionic hydrophilicizing agents are used.
  • component a3) can di- or polyamines such as 1, 2-ethylenediamine, 1,2- and 1, 3-diaminopropane, 1, 4-diaminobutane, 1, 6-diaminohexane, isophoronediamine, isomer mixture of 2,2,4- and 2,4,4-trimethylhexamethylenediamine, 2-methylpentamethylenediamine, diethylenetriamine, triaminononane, 1,3- and 1,4-xylylenediamine, a, a, a ', a'-tetramethyl-l, 3- and -1,4 -xylylenediamine and 4,4-diaminodicyclohexylmethane and / or Dimethylethylendiamm be used. Also possible, but less preferred, is the use of hydrazine or hydrazides such as adipic dihydrazide.
  • component a3) compounds which, in addition to a primary amino group, also have secondary amino groups or, in addition to an amino group (primary or secondary), OH groups.
  • primary / secondary amines such as diethanolamine, 3-amino-1-methylaminopropane, 3-amino-1-ethylaminopropane, 3-amino-1-cyclohexylaminopropane, 3-amino-1-methylaminobutane, alkanolamines, such as N-aminoethylethanolamine , Ethanolamine, 3-aminopropanol, neopentanolamine.
  • component a3) it is also possible to use monofunctional isocyanate-reactive amine compounds such as methylamine, ethylamine, propylamine, butylamine, octylamine, laurylamine, stearylamine, isononyloxypropylamine, dimethylamine, diethylamine, dipropylamine, dibutylamine, N-methylaminopropylamine, diethyl (methyl) aminopropylamine, morpholine, piperidine, or suitable substituted derivatives thereof, amide amines from diprimary amines and monocarboxylic acids, monoketime of diprimary amines, primary / tertiary amines, such as N, N-dimethylaminopropylamine,
  • Preferred compounds of component a3) are 1, 2-ethylenediamine, 1, 4-diaminobutane and isophoronediamine.
  • the preparation of the polyurethane dispersion a) can be carried out in one or more stages in homogeneous or multistage reaction, partly in disperse phase. After completely or partially carried out polyaddition of aal) to aa4) can follow a dispersing, emulsifying or dissolving step. Subsequently, if appropriate, a further polyaddition or modification in disperse or dissolved (homogeneous) phase can be carried out. For this purpose, all known from the prior art methods such. Example, prepolymer mixing method, acetone method or Schmelzdispergier vide can be used. Preference is given to working by the acetone process.
  • NH 2 - and / or NH-f ional components with the remaining isocyanate groups of the prepolymer can be partially or completely implemented.
  • chain extension / termination is performed prior to dispersion in water.
  • the chain extension of the prepolymers preferably takes place before the dispersion.
  • the aminic components a2) and a3) can optionally be used individually or in mixtures in water-diluted or solvent-diluted form, it being possible in principle for any order of addition to be possible.
  • the dispersion preferably takes place after the chain extension.
  • the dissolved and chain-extended polyurethane polymer a) is optionally either added to the dispersing water under high shear, such as vigorous stirring, or it is reacted.
  • the dispersing water is stirred to the chain-extended polyurethane polymer solutions.
  • the water is added to the dissolved chain-extended polyurethane polymer.
  • the organic solvent still present in the dispersions after the dispersing step is then usually removed by distillation. A distance already during the dispersion is also possible.
  • the residual content of organic solvents in the polyurethane dispersion a) is typically less than 1.0 wt .-%, preferably less than 0.5 wt .-%, based on the total dispersion.
  • the pH of the polyurethane dispersion a) is typically less than 9.0, preferably less than 8.5, more preferably less than 8.0, and most preferably 6.0 to 7.5.
  • the solids content of the polyurethane dispersion a) is typically 40 to 70, preferably 50 to 65, particularly preferably 55 to 65 wt .-%. Further dilution of the dispersion with water before use is also possible, as is the use of the dispersion and water as an independent constituent of the composition.
  • all known anionic, cationic, amphoteric and nonionic surfactants and mixtures thereof may be added to the dispersion a).
  • Alkyl polyglycosides, EO / PO block copolymers, alkyl or aryl alkoxylates, siloxane alkoxylates, esters of sulfosuccinic acid and / or alkali metal or alkaline earth metal alkanoates are preferably used. Particular preference is given to using EO / PO block copolymers. Very particular preference is given to using EO / PO block copolymers alone as component C).
  • an isocyanate-functional prepolymer b) obtainable by reacting at least the following components: bl) an aliphatic diisocyanate having a molar mass of 140 to 278 g / mol, b2) a di- to hexafunctional, is preferred a tri- to hexafunctional polyalkylene oxide having an OH number of 22.5 to 1 12 and an ethylene oxide content of 50 to 100 mol%, based on the total amount of oxyalkylene groups contained.
  • the prepolymers b) preferably have a residual monomer content of less than 0.5% by weight, based on the prepolymer.
  • This content can be achieved by appropriately selected amounts of the diisocyanates bl) and the polyalkylene oxides b2). However, preference is given to using the diisocyanate bl) in excess and then, preferably by distillation, separation of unreacted monomers.
  • the ratio of the polyalkylene oxides b2) to the diisocyanates b1) can typically be adjusted so that 2 to 20 mol, preferably 2 to 10 mol and more preferably 5 to 1 mol of OH groups of the polyalkylene oxides A2) to 10 moles of NCO groups of the diisocyanate bl) come.
  • the reaction of components bl) and b2) can be carried out in the presence of urethanization catalysts such as tin compounds, zinc compounds, amines, guanidines or amidines, or in the presence of allophanatization catalysts such as zinc compounds.
  • Acidic or alkylating stabilizers such as benzoyl chloride, isophthaloyl chloride, methyl tosylate, chloropropionic acid, HCl or antioxidants, such as di-tert-butylcresol or tocopherol, can be added before, during and after the reaction or distillative removal of the diisocyanate excess.
  • the NCO content of the isocyanate-functional prepolymer b) is preferably from 1.5 to 4.5% by weight, more preferably from 1.5 to 3.5% by weight and very particularly preferably from 1.5 to 3.0% by weight. %.
  • aliphatic diisocyanate bl examples include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), butylene diisocyanate (BDI), bisisocyanatocyclohexylmethane (HMDI), 2,2,4-trimethylhexamethylene diisocyanate, bisisocyanatomethylcyclohexane, bisisocyanoatomethyltricyclodecane, xylene diisocyanate, tetramethylxylylene diisocyanate, bornane diisocyanate, cyclohexane diisocyanate or diisocyanatododecane, wherein hexamethylene diisocyanate, isophorone diisocyanate, butylene diisocyanate and bis (isocyanatocyclohexyl) methane are preferred. Particularly preferred are butylene diisocyanate, hexamethylene diisocyanate,
  • the polyalkylene oxides b2) are preferably copolymers of ethylene oxide and propylene oxide having an ethylene oxide content, based on the total amount of the oxyalkylene groups, of from 50 to 100 mol%, preferably from 60 to 85 mol%, started on polyols or amines.
  • Suitable initiators of this type are glycerol, trimethylolpropane (TMP), sorbitol, pentaerythritol, triethanolamine, ammonia or ethylenediamine.
  • the polyalkylene oxides b2) typically have number-average molecular weights of from 1000 to 15000 g / mol, preferably from 3000 to 8500 g / mol.
  • polyalkylene oxides b2) preferably have OH functionalities of 2 to 6, more preferably of 3 to 6 and particularly preferably of 3 to 4.
  • Heterocyclic, 4-ring or 6-membered oligomers d) of aliphatic diisocyanates, in particular having a molar mass of 140 to 278 g / mol such as isocyanurates, iminooxadiazinediones or uretdiones of the abovementioned aliphatic diisocyanates, can be used as further components in the preparation of the polyurethane foam
  • Diisocyanates bl) can be used.
  • component d) content of isocyanate groups provides for a better foaming, as in the isocyanate-water reaction more CO 2 is formed.
  • catalysts e) are used in the production of the polyurethane foam B). These are typically the compounds known to those skilled in polyurethane technology. Preference is given here to compounds of the group consisting of catalytically active metal salts, amines, amidines and guanidines.
  • Examples include tin dibutyl dilaurate (DBTL), tin acetate, 1, 8-diazabicyclo [5.4.0] undecene-7 (DBU), 1, 5-diazabicyclo [4.3.0] nonene-5 (DBN), 1,4 Diazabicyclo [3.3.0] octene-4 (DBO), N-ethylmorpholine (NEM), triethylenediamine (DABCO), pentamethylguanidine (PMG), tetramethylguanidine (TMG), cyclotetramethylguanidine (TMGC), n-decyl-tetramethylguanidine (TMGD ), n-dodecyltetramethylguanidine (TMGDO), dimethylaminoethyltetramethylguanidine (TMGN), 1,1,4,4,5,5-hexamethylisobiguanidine (HMIB), phenyltetramethylguanidine (TMGP) and hexamethyle
  • DBU 1,8-diazabicyclo [5.4.0] undecene-7
  • catalysts e) are dispensed with completely.
  • Cs to C22 monocarboxylic acids or their ammonium or alkali metal salts or C12 to C44 dicarboxylic acids or their ammonium or alkali metal salts f) can be reacted with.
  • suitable compounds of component f) are the ammonium, Na, Li or K salts of ethylhexanoic, octanoic, decanoic, dodecanoic, palmitic, stearic, octadecenoic, octadecadienoic, octadecatrienoic, isostearic, erucic, abietic and their acids hydrogenation.
  • C 12 to C 44 dicarboxylic acids and the ammonium and alkali salts derived therefrom are dodecanedioic, dodecenyl, tetradecenyl, hexadecenyl and octadecenyl succinic acid, C 36 and C 44 dimer fatty acids and their hydrogenation products and the corresponding ammonium, Na, Li or K salts of these dicarboxylic acids.
  • components of component g) can be used, wherein such additives may in principle be all anionic, cationic, amphoteric and nonionic surfactants known per se and mixtures thereof.
  • Alkyl polyglycosides, EO / PO block copolymers, alkyl or aryl alkoxylates, siloxane alkoxylates, esters of sulfosuccinic acid and / or alkali metal or alkaline earth metal alkanoates are preferably used. It is particularly preferable to use EO / PO block copolymers. Preferably, only the EO / PO block copolymers are used as component g).
  • components of component h) can be used.
  • mono- or polyhydric alcohols or polyols such as ethanol, propanol, buta- nol, decanol, tridecanol, hexadecanol, ethylene glycol, neopentyl glycol, butanediol, hexanediol, decanediol, trimethylolpropane, glycerol, pentaerythritol, monofunctional polyether alcohols and polyester alcohols, polyether diols and polyester diols.
  • hydrophilic polyisocyanates i) can be used, which by reaction of
  • the ratio of the monofunctional polyalkylene oxides i2) to the aliphatic diisocyanates 1) is typically adjusted so that for 1 mol of OH groups of the monofunctional polyalkylene oxides from 1.25 to 15 mol, preferably with 2 to 10 mol and more preferably 2 to 6 moles of NCO groups of the aliphatic diisocyanate il) come. Subsequently, the allophanatization or biurization and / or isocyanurate formation or uretdione formation takes place. If the polyalkylene oxides i2) are bound via urethane groups to the aliphatic diisocyanates II), allophanatization preferably takes place subsequently. It is further preferred that isocyanurate structural units are formed.
  • hydrophilic polyisocyanates i) is typically carried out by reacting 1 mol of OH groups of the monofunctional polyalkylene oxide component i2) with 1, 25 to 15 mol, preferably with 2 to 10 mol and particularly preferably 2 to 6 moles NCO groups of a polyisocyanate il) with an isocyanate functionality of 2 to 6, based on aliphatic disocyanates.
  • exemplary of such polyisocyanates II) are biuret
  • the polyisocyanate II) and the polyalkylene oxide i2) are preferably linked to one another via a urethane group or a urea group, the linking via urethane groups in particular being preferred.
  • the reaction of the components II) and II) can be carried out in the presence of urethanization catalysts such as tin compounds, zinc compounds, amines, guanidines or amidines, or in the presence of allophanatization catalysts such as zinc compounds.
  • the reaction of il) and i2) is typically carried out at 25 to 140 ° C, preferably at 60 to 100 ° C.
  • Acidic or alkylating stabilizers such as benzoyl chloride, isophthaloyl chloride, methyl tosylate, chloropropionic acid, HCl or antioxidants, such as di-tert-butylcresol or tocopherol, can be added before, during and after the reaction or the distillative removal of the diisocyanate excess.
  • the NCO content of the hydrophilic polyisocyanates i) is preferably 0.3 to 20 wt .-%, more preferably 2 to 10 wt .-% and most preferably 3 to 6 wt .-%.
  • aliphatic diisocyanates of component II) are hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), butylene diisocyanate (BDI), bisisocyanatocyclohexylmethane (HMDI), 2,2,4-trimethylhexamethylene diisocyanate, bisisocyanatomethylcyclohexane, bisisocyanatomethyltricyclodecane, xylene diisocyanate, tetramethylxylylene diisocyanate, norbornene diisocyanate , Cyclohexane diisocyanate or diisocyanatododecane, with hexamethylene diisocyanate, isophorone diisocyanate, butylene diisocyanate and bis (isocyanatocyclohexyl) methane being preferred. Particularly preferred are butylene diisocyanate, hexamethylene diisocyanate,
  • polyisocyanates II are polyisocyanates having an isocyanate functionality of 2 to 6 with isocyanurate, urethane, allophanate, biuret, iminooxadiazinetrione, oxadiazinetrione and / or uretdione groups based on the aliphatic and / or aliphatic groups mentioned in the preceding paragraph cycloaliphatic diisocyanates.
  • Compounds with biuret, iminooxadiazinedione, isocyanurate and / or uretdione groups based on hexamethylene diisocyanate, isophorone diisocyanate and / or 4,4'-diisocyanatodicyclohexylmethane are preferably used as component II). Further preferred are iso- cyanurates. Very particular preference is given to structures based on hexamethylene diisocyanate.
  • the monofunctional polyalkylene oxides i2) have an OH number of from 15 to 250, preferably from 28 to 112, and an ethylene oxide content of from 50 to 100 mol%, preferably from 60 to 100 mol%, based on the total amount of the oxyalkylene groups present.
  • monofunctional polyalkylene oxides in the context of the invention are meant compounds which are only one isocyanate-reactive group, i. a group capable of reacting with an NCO group.
  • Suitable starter molecules are, in particular, saturated monoalcohols, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, diethylene glycol monobutyl ether and aromatic alcohols, such as phenol or monoamines, such as diethylamine.
  • Preferred starter molecules are saturated monoalcohols of the aforementioned type. Particular preference is given to using diethylene glycol monobutyl ether or n-butanol as starter molecules.
  • the monofunctional polyalkylene oxides i2) typically have number average molecular weights of from 220 to 3700 g / mol, preferably from 500 to 2800 g / mol.
  • the monofunctional polyalkylene oxides i2) preferably have an OH group as the isocyanate-reactive group.
  • the components b) to i) are used in the following amounts:
  • the polyurethane foam B) is preferably produced by mixing the components, with water preferably being added as the last component, foaming the resulting mixture, applying the foamed mixture to a substrate by means of a doctor blade and then curing, preferably by chemical crosslinking.
  • the substrate may be, for example, a release paper or also the polyurethane foam A).
  • residual moisture which is still present may optionally be removed by means of conventional methods, such as e.g. be removed by convective air or microwave drying.
  • the absorption layer is directly connected to the storage layer.
  • the storage layer for example, no additional adhesive layer is necessary to bond the layers together.
  • the transition of liquid from the absorption layer into the storage layer takes place particularly quickly here.
  • the direct connection of the absorption layer with the storage layer can be realized according to a particularly preferred embodiment by either the polyurethane foam A) on the already finished polyurethane foam B) or the polyurethane foam B) on the already finished polyurethane foam A) is applied.
  • the foamed polyurethane dispersion a) can be applied to the polyurethane foam B) and dried there.
  • the mixture of components b), c) and optionally d) -i) can be applied to the polyurethane foam A).
  • the absorption layer may have a thickness in the range from 0.3 to 6 mm, preferably from 0.5 to 5 mm and more preferably from 0.7 to 3 mm.
  • the storage layer may have a thickness in the range of 0.5 to 10 mm, preferably 1 to 8 mm, and more preferably 1.5 to 6 mm.
  • the invention further provides a process for producing a composite foam according to the invention, in which the polyurethane foam A) of the absorption layer is produced by mechanical foaming of the aqueous polyurethane dispersion a) and subsequent drying and the polyurethane foam B) of the storage layer by reacting at least the following components: b) an isocyanate-functional prepolymer, c) water and the absorption layer and the storage layer are at least partially connected directly.
  • the polyurethane dispersion a) is prepared by reacting at least the following components: al) an isocyanate-functional prepolymer, a2) optionally an isocyanate-reactive, preferably amino-functional, anionic or potentially anionic hydrophilicizing agent, a3) optionally an amino-functional compound, in particular having a molecular weight of 32 to 400 g / mol, a4) water, wherein the hydrophilicizing agent a2) is obligatory if the prepolymer al) does not have hydrophilicizing groups.
  • the isocyanate-functional prepolymer al) is prepared by reacting at least the following components: aa) an organic polyisocyanate, aa2) a polymeric polyol, in particular having a number average molecular weight of 400 to 8000 g / mol and / or an OH functionality of 1.5 to 6, aa3) optionally a hydroxy-functional compound, in particular having a molecular weight of 62 to 399 g / mol and aa4) optionally an isocyanate-reactive, anionic or potentially anionic and / or optionally nonionic hydrophilicizing agent.
  • the isocyanate-functional prepolymer b) is prepared by reacting at least one of the following components: bl) a low molecular weight, aliphatic diisocyanate having a molecular weight of 140 to 278 g / mol, b2) a di- to hexafunctional, preferably a tri- to hexafunctional polyalkylene oxide having an OH number of 22.5 to 1 12 and an ethylene oxide content of 50 to 100 mol%, based on the total amount of oxyalkylene groups contained.
  • the absorption layer is connected directly to the storage layer.
  • a wound dressing comprising a composite foam according to the invention or a composite foam obtainable according to a method according to the invention.
  • the wound dressing may additionally have a covering layer, which may in particular be connected to the storage layer.
  • Suitable cover layers are, for example, films, films, foams or membranes.
  • the cover layer can be made water vapor permeable according to DIN 53333 or DIN 54101.
  • the cover layer may preferably contain a thermoplastic polymer, for example in the form of a coating, or consist thereof.
  • a thermoplastic polymer is first understood to mean a polymer which, when used in the material for processing and Application typical temperature range repeatedly heated and cooled, remains thermoplastic.
  • thermoplastic is meant the property of a plastic to soften in a typical temperature range for him repeatedly in the heat and harden on cooling and be repeatedly formed in the softened state by flow, for example as a molded part, extrudate or forming part to semifinished or articles.
  • thermoplastic polymers are polyurethane, polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyether, polyester, polyamide, polycarbonate, polyether-polyamide copolymers, polyacrylate, polymethacrylate and / or polymaleate.
  • the thermoplastic polymers are elastomeric.
  • the carrier film contains thermoplastic polyurethane (TPU) or consists thereof.
  • thermoplastic polyurethanes which are selected from the group comprising aliphatic polyester polyurethanes, aromatic polyester polyurethanes, aliphatic polyether polyurethanes and / or aromatic polyether polyurethanes.
  • cover layers in the form of breathable elastic membrane films can be obtained. These are characterized by high flexibility and elasticity over a wide temperature range, a good seal for liquid water with high water vapor permeability, low noise, good textile feel, washing and cleaning resistance, very good chemical and mechanical resistance and freedom from plasticizers.
  • cover layer which acts as a barrier for germs and / has over the exudate exiting from the wound a high density with simultaneous permeability to water vapor.
  • the cover layer may be designed, for example, as a semipermeable membrane.
  • the cover layer has a thickness in the range of> 5 ⁇ to ⁇ 80 ⁇ , particularly preferably from> 5 ⁇ to ⁇ 60 ⁇ and very particularly preferably from> 10 ⁇ to ⁇ 30 ⁇ and / or an elongation at break of over 450%.
  • the wound dressing may additionally have an adhesive layer. This may preferably be connected to the absorption layer.
  • Suitable adhesive layers include, for example, polyurethane, silicone or acrylate-based pressure-sensitive adhesives.
  • polyurethane-based adhesives are hydrophilic polyurethane elastomers, as described, for example, in EP 1 923 077 and in EP 1 815 875 A1.
  • self-adhesive hydrophilic polyurethane gel foams known from WO 94/07935.
  • the wound dressing may also have a covering layer which is detachably connected to the adhesive layer and can be removed before application.
  • Suitable cover layers contain or consist of materials which have low adhesion to the adhesive of the adhesive layer when brought into contact therewith. Examples of such cover layers are release papers provided with a non-adhesive silicone or polyolefin layer.
  • the solids contents were determined according to DIN-EN ISO 3251.
  • the viscosities were determined at 23 ° C. and were carried out in accordance with DIN 53019.
  • the NCO contents were determined volumetrically according to DIN-EN ISO 11909.
  • Retention was determined on the basis of the determination of the absorption of physiological saline solution according to DIN EN 13726-1, Part 3.2, whereby the foam, soaked with physiological saline solution, was drained off for 30 s and then squeezed for 20 s with a 6 kg sample.
  • Retention in% is the amount of residual moisture divided by the maximum absorption.
  • the absorption rate was determined by placing with a Eppendorfpippette a 30 ⁇ l drop of a physiological saline solution (conditioned at 37 ° C.) on the surface of the foam and measuring the time until the drop had been completely absorbed in the foam.
  • the determination of the average particle sizes was carried out by means of laser correlation spectroscopy (instrument: Malvern Zetasizer 1000, Malver Inst. Limited).
  • the molecular weights were determined by gel permeation chromatography (GPC) as follows: The calibration was carried out with polystyrene standards having a molecular weight of Mp 1,000,000 to 162. The eluent used was tetrahydrofuran pA. The following parameters were observed during the double measurement: Degassing: Online - Degasser; By- flow: 1 ml / min; Analysis time: 45 minutes; Detectors: refractometer and UV detector; Injection volume: 100 ⁇ - 200 ⁇ . The calculation of the molar mass averages M w ; M n and M p and the polydispersity M w / M n was software-based.
  • Diaminosulphonate NH 2 -CH 2 CH 2 -NH-CH 2 CH 2 -SO 3 Na (45% in water)
  • Desmophen ® C2200 polycarbonate polyol, OH number 56 mg KOH / g, number average molecular weight 2000 g / mol (Bayer MaterialScience AG, Leverkusen, DE)
  • PolyTHF ® 2000 Polytetramethylenglykolpolyol, OH number 56 mg KOH / g, number average molecular weight 2000 g / mol (BASF AG, Ludwigshafen, DE)
  • PolyTHF ® 1000 Polytetramethylenglykolpolyol, OH number 112 mg KOH / g, number-average number average molecular weight 1000 g / mol (BASF AG, Ludwigshafen, DE)
  • Polyether LB 25 mono-functional polyether based on ethylene oxide / propylene oxide, number average molecular weight 2250 g / mol, OH number 25 mg KOH / g (Bayer MaterialScience AG, Leverkusen, DE) Desmodur® N 3400: Aliphatic polyisocyanate (HDI uretdione), NCO Content 21, 8%, Bayer MaterialScience AG, Leverkusen, Germany
  • Desmodur® N 3300 Aliphatic polyisocyanate (HDI isocyanurate), NCO content 21.8%, Bayer MaterialScience AG, Leverkusen, Germany
  • Pluronic PE6800 block polymer of propylene oxide and ethylene oxide, BASF, Ludwigshafen, Germany Preparation of the aqueous polyurethane dispersion a
  • the finished prepolymer was dissolved with 4840 g of acetone while cooled to 50 ° C and then a solution of 27.4 g of ethylenediamine, 127.1 g of isophoronediamine, 67.3 g of diaminosulfonate and 1200 g of water was added within 10 min , The stirring time was 10 min. It was then dispersed by adding 654 g of water. This was followed by removal of the solvent by distillation in vacuo.
  • the polyurethane dispersion obtained had the following properties:
  • Average particle size 528 nm pH (23 ° C): 7.5
  • Composite foams 1, 2 and 3 polyurethane foam B) on polyurethane foam A)
  • the polyurethane prepolymer al), the hydrophilic polyisocyanate i) and the oligomer B were homogenized for 15 seconds at a stirrer speed of 1200 rpm and then the other components in the amounts indicated in Table 1 were added. After mixing all the components, the mixture was stirred for a further 10 seconds at 1200 rpm and finally the finished composition was applied to the polyurethane foam A) using a doctor blade (gap height 0.7 or 1.5 mm). Here then formed the polyurethane foam B). The determination of the bulk density, absorption, retention and absorption rate was then carried out as described in the section "Methods.” The results are shown in Table 1.
  • Composite foam 4 polyurethane foam A) on polyurethane foam B) Preparation of polyurethane foam B):
  • the polyurethane prepolymer al), the hydrophilic polyisocyanate i) and Desmodur N3400 were homogenized for 15 seconds at a stirrer speed of 1200 rpm and then the other components in the amounts indicated in Table 1 were added. After mixing all the components, the mixture was stirred at 1200 rpm for a further 10 seconds and finally the finished composition was applied with a doctor blade (gap height 0.7 or 1.5 mm) to a siliconized release paper.
  • a doctor blade gap height 0.7 or 1.5 mm
  • the polyurethane prepolymer al), the hydrophilic polyisocyanate i) and Desmodur N3400 were homogenized for 15 seconds at a stirrer speed of 1200 rpm and then the other components in the amounts indicated in Table 1 were added. After mixing all the components, the mixture was stirred for a further 10 seconds at 1200 rpm and the finished composition was finally applied with a doctor blade (gap height 1.5 mm) to a siliconized release paper.
  • the comparison foam 5 or 6 formed. 1 2 3 4 5 6
  • Hydrophilic polyisocyanate i) 22.5 22.5 22.5 22.5 22.5 22.5 22.5 22.5 (g)
  • the composite foams of Examples 1, 2 and 4 correspond in terms of foam thickness, density, absorbency (suction) and retention of the foam of Comparative Example 6. At the same time, however, they have a significantly higher absorption rate.
  • the composite foam of Example 3 has a significantly higher absorption rate with comparable foam thickness, density, suction power and retention compared to Comparative Example 5.

Abstract

L'invention concerne une mousse de liaison présentant une couche d'absorption et une couche de stockage indirectement reliée, au moins par endroits, à la couche d'absorption. La couche d'absorption contient une mousse polyuréthane (A) qu'il est possible d'obtenir par moussage mécanique d'une dispersion aqueuse de polyuréthane (a) et par séchage consécutif de cette dernière, et la couche de stockage contient une mousse polyuréthane (B) qu'il est possible d'obtenir par la mise en réaction d'au moins les constituants suivants b) un prépolymère à fonction isocyanate, et de c) l'eau. L'invention concerne également un procédé de fabrication de ladite mousse de liaison, et un pansement contenant la mousse de liaison selon l'invention.
PCT/EP2012/062355 2011-06-29 2012-06-26 Mousse de liaison pour des pansements WO2013000910A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11171969.6 2011-06-29
EP11171969 2011-06-29

Publications (1)

Publication Number Publication Date
WO2013000910A1 true WO2013000910A1 (fr) 2013-01-03

Family

ID=44645258

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/062355 WO2013000910A1 (fr) 2011-06-29 2012-06-26 Mousse de liaison pour des pansements

Country Status (1)

Country Link
WO (1) WO2013000910A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3235520A1 (fr) * 2016-04-22 2017-10-25 Covestro Deutschland AG Procede de fabrication d'une mousse comprenant une particule, mousse a haute retention et pansement comprenant une telle mousse
WO2018206578A1 (fr) 2017-05-10 2018-11-15 Mölnlycke Health Care Ab Mousse composite dans le traitement de plaies
CN109219627A (zh) * 2016-06-07 2019-01-15 科思创德国股份有限公司 多层结构及其制造和用途
CN111363186A (zh) * 2018-12-25 2020-07-03 万华化学集团股份有限公司 聚氨酯泡沫材料及其制备方法和在伤口敷料中的应用
EP3702386A1 (fr) * 2019-02-28 2020-09-02 Covestro Deutschland AG Mousse composite pour articles d'hygiène

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2446440A1 (de) 1974-09-28 1976-04-08 Bayer Ag Verfahren zur herstellung von polyurethanen
WO1994007935A1 (fr) 1992-10-02 1994-04-14 Beiersdorf Ag Gels moussants hydrophiles de polyurethane, notamment pour le traitement de plaies profondes, pansements a base de gels moussants hydrophiles de polyurethane et procede de fabrication
EP0810256A1 (fr) * 1996-05-28 1997-12-03 Bayer Ag Procédé de préparation de blocs flexibles en mousse de polyuréthane
EP0916647A2 (fr) 1997-11-13 1999-05-19 Bayer Ag Agent hydrophile, procédé pour sa préparation et son utilisation comme agent dispersant pour des dispersions aqueuses de polyuréthane
WO2001088006A1 (fr) 2000-05-18 2001-11-22 Bayer Aktiengesellschaft Polyisocyanates modifies
EP1669382A2 (fr) * 2004-12-13 2006-06-14 Bayer MaterialScience AG Dispersions de polyuréthane-polyurée à haute teneur en particules solides
EP1815875A1 (fr) 2006-02-06 2007-08-08 Collano AG Pansement avec un adhesif de pression a base de polyurethane et son procédé de revêtement d'extrusion
EP1923077A1 (fr) 2006-11-07 2008-05-21 Paul Hartmann AG Pansement multicouche absorbant avec une couche hydrophile en contact de plaies
EP2028223A1 (fr) 2007-08-23 2009-02-25 Bayer MaterialScience AG Copolymères en bloc EO/PO en tant que stabilisateurs pour mousses PUR
WO2009100837A1 (fr) * 2008-02-15 2009-08-20 Bayer Materialscience Ag Matériau composite plan hautement flexible
EP2140888A1 (fr) 2008-07-04 2010-01-06 Bayer MaterialScience AG Composé feuilleté, adapté en tant que pansement, contenant une couche de mousse de polyuréthane, d'absorbeur et de revêtement
EP2143744A1 (fr) 2008-07-09 2010-01-13 Bayer MaterialScience AG Mousses de polyuréthane hydrophile et aliphatique

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2446440A1 (de) 1974-09-28 1976-04-08 Bayer Ag Verfahren zur herstellung von polyurethanen
WO1994007935A1 (fr) 1992-10-02 1994-04-14 Beiersdorf Ag Gels moussants hydrophiles de polyurethane, notamment pour le traitement de plaies profondes, pansements a base de gels moussants hydrophiles de polyurethane et procede de fabrication
EP0810256A1 (fr) * 1996-05-28 1997-12-03 Bayer Ag Procédé de préparation de blocs flexibles en mousse de polyuréthane
EP0916647A2 (fr) 1997-11-13 1999-05-19 Bayer Ag Agent hydrophile, procédé pour sa préparation et son utilisation comme agent dispersant pour des dispersions aqueuses de polyuréthane
WO2001088006A1 (fr) 2000-05-18 2001-11-22 Bayer Aktiengesellschaft Polyisocyanates modifies
EP1669382A2 (fr) * 2004-12-13 2006-06-14 Bayer MaterialScience AG Dispersions de polyuréthane-polyurée à haute teneur en particules solides
EP1815875A1 (fr) 2006-02-06 2007-08-08 Collano AG Pansement avec un adhesif de pression a base de polyurethane et son procédé de revêtement d'extrusion
EP1923077A1 (fr) 2006-11-07 2008-05-21 Paul Hartmann AG Pansement multicouche absorbant avec une couche hydrophile en contact de plaies
EP2028223A1 (fr) 2007-08-23 2009-02-25 Bayer MaterialScience AG Copolymères en bloc EO/PO en tant que stabilisateurs pour mousses PUR
WO2009100837A1 (fr) * 2008-02-15 2009-08-20 Bayer Materialscience Ag Matériau composite plan hautement flexible
EP2140888A1 (fr) 2008-07-04 2010-01-06 Bayer MaterialScience AG Composé feuilleté, adapté en tant que pansement, contenant une couche de mousse de polyuréthane, d'absorbeur et de revêtement
EP2143744A1 (fr) 2008-07-09 2010-01-13 Bayer MaterialScience AG Mousses de polyuréthane hydrophile et aliphatique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Ullmanns Encyclopädie der technischen Chemie", vol. 19, VERLAG CHEMIE, pages: 31 - 38

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3235520A1 (fr) * 2016-04-22 2017-10-25 Covestro Deutschland AG Procede de fabrication d'une mousse comprenant une particule, mousse a haute retention et pansement comprenant une telle mousse
CN109219627A (zh) * 2016-06-07 2019-01-15 科思创德国股份有限公司 多层结构及其制造和用途
WO2018206578A1 (fr) 2017-05-10 2018-11-15 Mölnlycke Health Care Ab Mousse composite dans le traitement de plaies
CN114795657A (zh) * 2017-05-10 2022-07-29 墨尼克医疗用品有限公司 伤口处理中的复合泡沫
US11628092B2 (en) 2017-05-10 2023-04-18 Mölnlycke Health Care Ab Composite foam in wound treatment
AU2018266750B2 (en) * 2017-05-10 2023-05-25 Mölnlycke Health Care Ab Composite foam in wound treatment
CN111363186A (zh) * 2018-12-25 2020-07-03 万华化学集团股份有限公司 聚氨酯泡沫材料及其制备方法和在伤口敷料中的应用
CN111363186B (zh) * 2018-12-25 2023-01-13 万华化学集团股份有限公司 聚氨酯泡沫材料及其制备方法和在伤口敷料中的应用
EP3702386A1 (fr) * 2019-02-28 2020-09-02 Covestro Deutschland AG Mousse composite pour articles d'hygiène

Similar Documents

Publication Publication Date Title
EP2704754B1 (fr) Mousse de polyuréthane hydrophile au gonflement volumique minime
EP2389400B1 (fr) Utilisation de mousses de dispersions polyuréthane à deux composants comme pansement pour plaie
EP2015786B1 (fr) Articles moussants biomédicaux
WO2010000400A1 (fr) Pansement stratifié, destiné à panser une plaie, comprenant une couche de mousse de polyuréthane, une couche absorbante et une couche de couverture
EP2010235B1 (fr) Procede de fabrication de mousses de polyurethanne
EP2197930B1 (fr) Procédé de fabrication de mousses de polyuréthane
EP2165718A1 (fr) Pansement doté d'une couche de mousse de polyuréthane et d'une couche de revêtement en polymère thermoplastique
EP2389402B1 (fr) Mousses de polyuréthanes stabilisées par tensioactif à base de polyuréthane
EP2066711B1 (fr) Alkylpolyglycosides utilisés comme stabilisants de mousses de polyuréthane
WO2009024266A1 (fr) Copolymères séquencés eo/po utilisés comme agents stabilisants pour des mousses polyuréthane
EP2045279A1 (fr) Mousses de polyuréthane pour le traitement de plaies
DE102007048079A1 (de) Verfahren zur Herstellung von Polyurethan-Schäumen
WO2013000910A1 (fr) Mousse de liaison pour des pansements
EP3235520A1 (fr) Procede de fabrication d'une mousse comprenant une particule, mousse a haute retention et pansement comprenant une telle mousse
WO2011069972A2 (fr) Mousses de polyuréthane aliphatique hydrophiles
WO2010022894A1 (fr) Procédé de production de pansements en mousse de polyuréthane moulée
WO2019137882A1 (fr) Procédé de fabrication de mousses de polyuréthane élastiques et résistantes au déchirement et leurs applications
EP2534187A1 (fr) Pansement à libération de principe actif
EP3702386A1 (fr) Mousse composite pour articles d'hygiène

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12731395

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12731395

Country of ref document: EP

Kind code of ref document: A1