WO2012173809A3 - Method of identifying de novo copy number variants (cnv) using mz twins discordant for attention problems/disorders - Google Patents

Method of identifying de novo copy number variants (cnv) using mz twins discordant for attention problems/disorders Download PDF

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Publication number
WO2012173809A3
WO2012173809A3 PCT/US2012/040795 US2012040795W WO2012173809A3 WO 2012173809 A3 WO2012173809 A3 WO 2012173809A3 US 2012040795 W US2012040795 W US 2012040795W WO 2012173809 A3 WO2012173809 A3 WO 2012173809A3
Authority
WO
WIPO (PCT)
Prior art keywords
identifying
cnv
disorders
copy number
number variants
Prior art date
Application number
PCT/US2012/040795
Other languages
French (fr)
Other versions
WO2012173809A2 (en
Inventor
Erik EHLI
Gareth Davies
Abdel ABDELLAOUI
James HUDZIAK
Original Assignee
Ehli Erik
Gareth Davies
Abdellaoui Abdel
Hudziak James
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ehli Erik, Gareth Davies, Abdellaoui Abdel, Hudziak James filed Critical Ehli Erik
Publication of WO2012173809A2 publication Critical patent/WO2012173809A2/en
Publication of WO2012173809A3 publication Critical patent/WO2012173809A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

The present disclosure relates to methods of identifying copy number variation (CNV) events and sizes that are associated with attention problems (AP) and identifying one or more CNVs which correlate with such disorders.
PCT/US2012/040795 2011-06-02 2012-06-04 Method of identifying de novo copy number variants (cnv) using mz twins discordant for attention problems/disorders WO2012173809A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161492783P 2011-06-02 2011-06-02
US61/492,783 2011-06-02

Publications (2)

Publication Number Publication Date
WO2012173809A2 WO2012173809A2 (en) 2012-12-20
WO2012173809A3 true WO2012173809A3 (en) 2013-04-04

Family

ID=47357667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/040795 WO2012173809A2 (en) 2011-06-02 2012-06-04 Method of identifying de novo copy number variants (cnv) using mz twins discordant for attention problems/disorders

Country Status (1)

Country Link
WO (1) WO2012173809A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106701900B (en) * 2015-11-16 2020-03-20 上海市东方医院 Long-chain non-coding RNA HERC2P3 gene and application thereof in gastric cancer
CN107423534B (en) * 2016-05-24 2021-08-06 郝柯 Method and system for detecting genome copy number variation
CN111028890B (en) * 2019-12-31 2020-09-11 东莞博奥木华基因科技有限公司 CNV detection method based on correction between run

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009105718A1 (en) * 2008-02-20 2009-08-27 The Children's Hospital Of Philadelphia Genetic alterations associated with autism and the autistic phenotype and methods of use thereof for the diagnosis and treatmemt of autism
US20090307180A1 (en) * 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
US20100143921A1 (en) * 2007-04-30 2010-06-10 The Ohio State University Research Foundation Polymorphisms in Genes Affecting Dopamine Transporter Disorders and Uses Thereof
US20100248235A1 (en) * 2007-10-04 2010-09-30 Scherer Stephen W Biomarkers for autism spectrum disorders
US20110111419A1 (en) * 2008-07-04 2011-05-12 deCODE Geneties ehf. Copy Number Variations Predictive of Risk of Schizophrenia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100143921A1 (en) * 2007-04-30 2010-06-10 The Ohio State University Research Foundation Polymorphisms in Genes Affecting Dopamine Transporter Disorders and Uses Thereof
US20100248235A1 (en) * 2007-10-04 2010-09-30 Scherer Stephen W Biomarkers for autism spectrum disorders
WO2009105718A1 (en) * 2008-02-20 2009-08-27 The Children's Hospital Of Philadelphia Genetic alterations associated with autism and the autistic phenotype and methods of use thereof for the diagnosis and treatmemt of autism
US20090307180A1 (en) * 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
US20110111419A1 (en) * 2008-07-04 2011-05-12 deCODE Geneties ehf. Copy Number Variations Predictive of Risk of Schizophrenia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ERIK A. EHLI ET AL.: "De novo and inherited CNVs in MZ twin pairs selected for discordance and concordance on Attention Problems", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 20, no. 10, 11 April 2012 (2012-04-11), pages 1037 - 1043 *

Also Published As

Publication number Publication date
WO2012173809A2 (en) 2012-12-20

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