WO2012164026A8 - Methods for diagnosing multiple sclerosis - Google Patents

Methods for diagnosing multiple sclerosis Download PDF

Info

Publication number
WO2012164026A8
WO2012164026A8 PCT/EP2012/060262 EP2012060262W WO2012164026A8 WO 2012164026 A8 WO2012164026 A8 WO 2012164026A8 EP 2012060262 W EP2012060262 W EP 2012060262W WO 2012164026 A8 WO2012164026 A8 WO 2012164026A8
Authority
WO
WIPO (PCT)
Prior art keywords
multiple sclerosis
methods
subject
diagnosing
diagnosing multiple
Prior art date
Application number
PCT/EP2012/060262
Other languages
French (fr)
Other versions
WO2012164026A1 (en
Inventor
Regina Reszka
Ulrike Rennefahrt
Susan Carvalho
Bernhard Hemmer
Original Assignee
Metanomics Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metanomics Health Gmbh filed Critical Metanomics Health Gmbh
Priority to JP2014513195A priority Critical patent/JP2014517300A/en
Priority to CA2834455A priority patent/CA2834455A1/en
Priority to EP12724645.2A priority patent/EP2715361A1/en
Priority to AU2012264688A priority patent/AU2012264688A1/en
Publication of WO2012164026A1 publication Critical patent/WO2012164026A1/en
Publication of WO2012164026A8 publication Critical patent/WO2012164026A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing multiple sclerosis in a subject, a method for identifying whether a subject is in need for a therapy of multiple sclerosis or a method for determining whether a multiple sclerosis therapy is successful. Moreover, contributed is a method for diagnosing or predicting the risk of an active status of multiple sclerosis in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
PCT/EP2012/060262 2011-05-31 2012-05-31 Methods for diagnosing multiple sclerosis WO2012164026A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2014513195A JP2014517300A (en) 2011-05-31 2012-05-31 Method for diagnosing multiple sclerosis
CA2834455A CA2834455A1 (en) 2011-05-31 2012-05-31 Methods for diagnosing multiple sclerosis
EP12724645.2A EP2715361A1 (en) 2011-05-31 2012-05-31 Methods for diagnosing multiple sclerosis
AU2012264688A AU2012264688A1 (en) 2011-05-31 2012-05-31 Methods for diagnosing multiple sclerosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161491353P 2011-05-31 2011-05-31
EP11168266.2 2011-05-31
US61/491,353 2011-05-31
EP11168266 2011-05-31

Publications (2)

Publication Number Publication Date
WO2012164026A1 WO2012164026A1 (en) 2012-12-06
WO2012164026A8 true WO2012164026A8 (en) 2013-04-18

Family

ID=47258397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/060262 WO2012164026A1 (en) 2011-05-31 2012-05-31 Methods for diagnosing multiple sclerosis

Country Status (5)

Country Link
EP (1) EP2715361A1 (en)
JP (1) JP2014517300A (en)
AU (1) AU2012264688A1 (en)
CA (1) CA2834455A1 (en)
WO (1) WO2012164026A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010326737A1 (en) * 2009-12-01 2012-06-07 Metanomics Health Gmbh Means and methods for diagnosing multiple sclerosis
EP2580596B1 (en) 2010-06-10 2015-02-25 Metanomics Health GmbH Methods to diagnose liver diseases
MA41139A (en) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd PHARMACEUTICAL COMBINATION INCLUDING A SIP1 RECEPTOR SELECTIVE AGONIST
US11061034B2 (en) 2015-10-14 2021-07-13 Public University Corporation Yokohama City University Blood biomarker for use in evaluation of effect of drug therapy on kidney cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5397894A (en) 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
WO2003073464A1 (en) 2002-02-28 2003-09-04 Metanomics Gmbh & Co. Kgaa Mass spectrometry method for analysing mixtures of substances
NL1021892C2 (en) * 2002-11-11 2004-05-12 Tno Detection of demyelination.
US8026099B2 (en) * 2007-07-26 2011-09-27 Washington University Lipid profile as a biomarker for early detection of neurological disorders

Also Published As

Publication number Publication date
AU2012264688A2 (en) 2014-01-23
JP2014517300A (en) 2014-07-17
CA2834455A1 (en) 2012-12-06
WO2012164026A1 (en) 2012-12-06
AU2012264688A8 (en) 2013-12-19
EP2715361A1 (en) 2014-04-09
AU2012264688A1 (en) 2013-11-21

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