WO2012156987A3 - Novel process for preparation of eslicarbazepine - Google Patents

Novel process for preparation of eslicarbazepine Download PDF

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Publication number
WO2012156987A3
WO2012156987A3 PCT/IN2012/000323 IN2012000323W WO2012156987A3 WO 2012156987 A3 WO2012156987 A3 WO 2012156987A3 IN 2012000323 W IN2012000323 W IN 2012000323W WO 2012156987 A3 WO2012156987 A3 WO 2012156987A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
eslicarbazepine
novel process
dibenz
azepine
Prior art date
Application number
PCT/IN2012/000323
Other languages
French (fr)
Other versions
WO2012156987A2 (en
Inventor
Milind Moreshwar Gharpure
Dnyandev Rane
Sunil Sudhakar Zope
Krishna Baban NARAWADE
Amit Anant THANEDAR
Original Assignee
Glenmark Generics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Generics Limited filed Critical Glenmark Generics Limited
Publication of WO2012156987A2 publication Critical patent/WO2012156987A2/en
Publication of WO2012156987A3 publication Critical patent/WO2012156987A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Disclosed are a process for the preparation of (S)-(+)-10,ll-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide (eslicarbazepine), (S)-(-)-10-(acetyloxy)-10,ll-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (eslicarbazepine acetate) and novel compounds that may be useful intermediates in the preparation thereof.
PCT/IN2012/000323 2011-05-19 2012-05-02 A novel process for the preparation of eslicarbazepine WO2012156987A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1533MU2011 2011-05-19
IN1533/MUM/2011 2011-05-19

Publications (2)

Publication Number Publication Date
WO2012156987A2 WO2012156987A2 (en) 2012-11-22
WO2012156987A3 true WO2012156987A3 (en) 2013-03-21

Family

ID=47177403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000323 WO2012156987A2 (en) 2011-05-19 2012-05-02 A novel process for the preparation of eslicarbazepine

Country Status (1)

Country Link
WO (1) WO2012156987A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092572A1 (en) * 2001-05-11 2002-11-21 Portela & Ca Sa Method for preparation of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide
WO2004099153A1 (en) * 2003-05-12 2004-11-18 Portela & C.A., S.A. Method for racemisation of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h­dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof
WO2006005951A1 (en) * 2004-07-13 2006-01-19 Portela & C.A. S.A. Method for chiral inversion of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof
WO2006056339A1 (en) * 2004-11-26 2006-06-01 Farchemia S.R.L. A process for the preparation of (s)-(+)-10,11-dihydro-10-hydroxy-5h-dibenz (b,f) azepine-5-carboxyamide
WO2010113179A2 (en) * 2009-04-02 2010-10-07 Glenmark Generics Limited A process for the purification of eslicarbazepine acetate
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092572A1 (en) * 2001-05-11 2002-11-21 Portela & Ca Sa Method for preparation of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide
WO2004099153A1 (en) * 2003-05-12 2004-11-18 Portela & C.A., S.A. Method for racemisation of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h­dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof
WO2006005951A1 (en) * 2004-07-13 2006-01-19 Portela & C.A. S.A. Method for chiral inversion of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof
WO2006056339A1 (en) * 2004-11-26 2006-06-01 Farchemia S.R.L. A process for the preparation of (s)-(+)-10,11-dihydro-10-hydroxy-5h-dibenz (b,f) azepine-5-carboxyamide
WO2010113179A2 (en) * 2009-04-02 2010-10-07 Glenmark Generics Limited A process for the purification of eslicarbazepine acetate
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs

Also Published As

Publication number Publication date
WO2012156987A2 (en) 2012-11-22

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