WO2012153338A3 - Liposomes comprising polymer-conjugated lipids and related uses - Google Patents

Liposomes comprising polymer-conjugated lipids and related uses Download PDF

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Publication number
WO2012153338A3
WO2012153338A3 PCT/IL2012/050168 IL2012050168W WO2012153338A3 WO 2012153338 A3 WO2012153338 A3 WO 2012153338A3 IL 2012050168 W IL2012050168 W IL 2012050168W WO 2012153338 A3 WO2012153338 A3 WO 2012153338A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
liposomes
subject
administering
related uses
Prior art date
Application number
PCT/IL2012/050168
Other languages
French (fr)
Other versions
WO2012153338A2 (en
Inventor
Saul Yedgar
Original Assignee
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES12781987T priority Critical patent/ES2762224T3/en
Priority to CA2834918A priority patent/CA2834918C/en
Priority to JP2014509889A priority patent/JP2014519493A/en
Priority to DK12781987.8T priority patent/DK2706988T3/en
Priority to EP12781987.8A priority patent/EP2706988B1/en
Priority to CN201280022911.3A priority patent/CN104023708A/en
Priority to AU2012254842A priority patent/AU2012254842A1/en
Priority to US14/115,869 priority patent/US10179106B2/en
Application filed by Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. filed Critical Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
Publication of WO2012153338A2 publication Critical patent/WO2012153338A2/en
Priority to IL229325A priority patent/IL229325A0/en
Publication of WO2012153338A3 publication Critical patent/WO2012153338A3/en
Priority to US16/246,920 priority patent/US10624851B2/en
Priority to US16/853,635 priority patent/US20200246265A1/en
Priority to US17/377,134 priority patent/US11911507B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)

Abstract

The present invention provides liposomes comprising a lipid bilayer and a polymer- conjugated lipid, wherein said polymer-conjugated lipid is incorporated into said lipid bilayer. The present invention also provides methods of producing the liposomes as well as a method of delivering a nucleic acid to a subject comprising the step of administering said nucleic acid encapsulated in a mixed liposome, a method for performing diagnostic imaging in a subject, comprising the step of administering a diagnostic agent encapsulated in a mixed liposome, and methods for treating, inhibiting, or suppressing a pathological condition in a subject comprising administering to said subject a mixed liposome.
PCT/IL2012/050168 2011-05-12 2012-05-10 Liposomes comprising polymer-conjugated lipids and related uses WO2012153338A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AU2012254842A AU2012254842A1 (en) 2011-05-12 2012-05-10 Liposomes comprising polymer-conjugated lipids and related uses
JP2014509889A JP2014519493A (en) 2011-05-12 2012-05-10 Liposomes containing polymer conjugated lipids and related uses
DK12781987.8T DK2706988T3 (en) 2011-05-12 2012-05-10 LIPOSOMES COMPREHENSIVE POLYMER CONJUGATED LIPIDS AND RELATED USE
EP12781987.8A EP2706988B1 (en) 2011-05-12 2012-05-10 Liposomes comprising polymer-conjugated lipids and related uses
CN201280022911.3A CN104023708A (en) 2011-05-12 2012-05-10 Liposomes comprising polymer-conjugated lipids and related uses
ES12781987T ES2762224T3 (en) 2011-05-12 2012-05-10 Liposomes Comprising Polymer Conjugated Lipids and Related Uses
CA2834918A CA2834918C (en) 2011-05-12 2012-05-10 Liposomes comprising polymer-conjugated lipids and related uses
US14/115,869 US10179106B2 (en) 2011-05-12 2012-05-10 Liposomes comprising polymer-conjugated lipids and related uses
IL229325A IL229325A0 (en) 2011-05-12 2013-11-07 Liposomes comprising polymer-conjugated lipids and related uses
US16/246,920 US10624851B2 (en) 2011-05-12 2019-01-14 Liposomes comprising polymer-conjugated lipids and related uses
US16/853,635 US20200246265A1 (en) 2011-05-12 2020-04-20 Liposomes comprising polymer-conjugated lipids and related uses
US17/377,134 US11911507B2 (en) 2011-05-12 2021-07-15 Liposomes comprising polymer-conjugated lipids and related uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161485192P 2011-05-12 2011-05-12
US61/485,192 2011-05-12

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/115,869 A-371-Of-International US10179106B2 (en) 2011-05-12 2012-05-10 Liposomes comprising polymer-conjugated lipids and related uses
US16/246,920 Continuation US10624851B2 (en) 2011-05-12 2019-01-14 Liposomes comprising polymer-conjugated lipids and related uses

Publications (2)

Publication Number Publication Date
WO2012153338A2 WO2012153338A2 (en) 2012-11-15
WO2012153338A3 true WO2012153338A3 (en) 2014-06-12

Family

ID=47139753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2012/050168 WO2012153338A2 (en) 2011-05-12 2012-05-10 Liposomes comprising polymer-conjugated lipids and related uses

Country Status (9)

Country Link
US (4) US10179106B2 (en)
EP (1) EP2706988B1 (en)
JP (1) JP2014519493A (en)
CN (1) CN104023708A (en)
AU (1) AU2012254842A1 (en)
CA (1) CA2834918C (en)
DK (1) DK2706988T3 (en)
ES (1) ES2762224T3 (en)
WO (1) WO2012153338A2 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
RS66304B1 (en) 2010-10-01 2025-01-31 Modernatx Inc Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
EP2706988B1 (en) * 2011-05-12 2019-12-04 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Liposomes comprising polymer-conjugated lipids and related uses
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
KR102014061B1 (en) 2011-10-03 2019-08-28 모더나 세라퓨틱스, 인코포레이티드 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2015501844A (en) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Modified nucleosides, nucleotides and nucleic acid compositions
US8999380B2 (en) 2012-04-02 2015-04-07 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
LT2922554T (en) 2012-11-26 2022-06-27 Modernatx, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
ITMI20130576A1 (en) * 2013-04-11 2014-10-12 Labomar S R L COMPOSITION INCLUDING A POLYAMINOGLICOSIDE
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
CA2926218A1 (en) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2015068155A1 (en) * 2013-11-06 2015-05-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Lipid-polysaccharide conjugates, their preparation and uses thereof
BE1022346A9 (en) * 2014-03-12 2016-10-07 Glaxosmithkline Biologicals Sa LIPOSOMAL COMPOSITIONS FOR MUCOSAL ADMINISTRATION
US10307491B2 (en) 2015-01-30 2019-06-04 The Regents Of The University Of Michigan Liposomal particles comprising biological molecules and uses thereof
RU2642786C2 (en) * 2015-01-30 2018-01-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Liposomal suspensions stabiliser
US11219673B2 (en) 2015-03-25 2022-01-11 The Regents Of The University Of Michigan Compositions and methods for delivery of biomacromolecule agents
LT3350157T (en) 2015-09-17 2022-02-25 Modernatx, Inc. COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC SUBSTANCES
WO2017099823A1 (en) 2015-12-10 2017-06-15 Modernatx, Inc. Compositions and methods for delivery of therapeutic agents
SMT202200252T1 (en) 2015-12-22 2022-07-21 Modernatx Inc Compounds and compositions for intracellular delivery of agents
WO2017223085A2 (en) 2016-06-20 2017-12-28 The Regents Of The University Of Michigan Compositions and methods for delivery of biomacromolecule agents
WO2018089540A1 (en) 2016-11-08 2018-05-17 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
WO2018089799A1 (en) * 2016-11-11 2018-05-17 Dnalite Therapeutics, Inc. Structures and methods for gene therapy
KR20190132405A (en) 2017-03-15 2019-11-27 모더나티엑스, 인크. Compounds and Compositions for Intracellular Delivery of Therapeutic Agents
WO2018170336A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
DK3596042T3 (en) 2017-03-15 2022-04-11 Modernatx Inc CRYSTAL FORMS OF AMINOLIPIDS
EP3638678A1 (en) 2017-06-14 2020-04-22 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
US11786607B2 (en) 2017-06-15 2023-10-17 Modernatx, Inc. RNA formulations
EP3675817A1 (en) 2017-08-31 2020-07-08 Modernatx, Inc. Methods of making lipid nanoparticles
CN109833297B (en) * 2017-11-27 2021-10-29 张正风 A kind of liposome composition
EP3812376A4 (en) * 2018-06-20 2022-08-17 Santolecan Pharmaceuticals LLC Paclitaxel-lipid-polysaccharide dual-type conjugate, preparation method therefor and use thereof
CA3113436A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
MA53650A (en) 2018-09-19 2021-07-28 Modernatx Inc PEG LIPIDS AND THEIR USES
CN113271926A (en) 2018-09-20 2021-08-17 摩登纳特斯有限公司 Preparation of lipid nanoparticles and methods of administration thereof
MX2021013273A (en) * 2019-05-05 2022-01-06 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Restoration of the cftr function by splicing modulation.
US12195755B2 (en) 2019-05-20 2025-01-14 Brown University Placental lipid bilayer for cell-free molecular interaction studies
US11273124B2 (en) * 2019-05-23 2022-03-15 Brown University Antifungal nanoparticles for targeted treatment of fungal infections
BR112022004759A2 (en) 2019-09-19 2022-06-21 Modernatx Inc Branched tail lipid compositions and compounds for intracellular delivery of therapeutic agents
US11524023B2 (en) 2021-02-19 2022-12-13 Modernatx, Inc. Lipid nanoparticle compositions and methods of formulating the same
IT202100022253A1 (en) * 2021-08-24 2023-02-24 Univ Degli Studi Di Torino LIPOSOMES, COMPOSITIONS INCLUDING THEM, THEIR USES
WO2025030098A1 (en) * 2023-08-03 2025-02-06 President And Fellows Of Harvard College Glycolipid functionalized liposomes or other vesicles for use as drug delivery systems or other applications
WO2025064631A1 (en) * 2023-09-20 2025-03-27 The Board Of Trustees Of The University Of Illinois Use of a dry powder inhaler to treat or prevent pulmonary fungal infections

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395619A (en) * 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US20040241855A1 (en) * 1999-04-20 2004-12-02 The University Of British Columbia Cationic peg-lipids and methods of use
US20070185052A1 (en) * 2005-08-03 2007-08-09 Saul Yedgar Use of lipid conjugates in cystic fibrosis and applications thereof
US20100209490A1 (en) * 2007-08-09 2010-08-19 Daiichi Sankyo Company, Limited Immunoliposome inducing apoptosis into cell expressing death domain-containing receptor
WO2011017297A2 (en) * 2009-08-03 2011-02-10 The University Of North Carolina At Chapel Hill Biodegradable delivery system complexes for the delivery of bioactive compounds

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US5688488A (en) 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
JP3407072B2 (en) * 1991-02-14 2003-05-19 バクスター、インターナショナル、インコーポレイテッド Binding of recognition substance to liposome
US5603872A (en) * 1991-02-14 1997-02-18 Baxter International Inc. Method of binding recognizing substances to liposomes
US5785975A (en) * 1995-06-26 1998-07-28 Research Triangle Pharmaceuticals Adjuvant compositions and vaccine formulations comprising same
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
US6071532A (en) * 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
US7311924B2 (en) * 1999-04-01 2007-12-25 Hana Biosciences, Inc. Compositions and methods for treating cancer
US7141552B2 (en) 2000-01-10 2006-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
EP1471870B1 (en) 2000-01-10 2014-08-20 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Use of lipid conjugates in the treatment of disease
EP1332368A2 (en) 2000-11-03 2003-08-06 Board of Regents, The University of Texas System Methods for detecting the efficacy of anticancer treatments
US8883761B2 (en) 2001-01-10 2014-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases associated with vasculature
DE10252614A1 (en) * 2002-11-12 2004-05-27 Infineon Technologies Ag Method, device, computer-readable storage medium and computer program element for monitoring a manufacturing process of a plurality of physical objects
US20050276756A1 (en) * 2004-03-24 2005-12-15 Hoo William S Compositions as adjuvants to improve immune responses to vaccines and methods of use
CN101282733A (en) * 2005-08-03 2008-10-08 莫里亚生物制药公司 The use and application of lipid conjugates in cystic fibrosis
US20110130555A1 (en) 2009-05-11 2011-06-02 Saul Yedgar Lipid-polymer conjugates, their preparation and uses thereof
AU2010270337B2 (en) * 2009-07-09 2016-09-22 Biontech Delivery Technologies Gmbh Amphoteric liposomes comprising imino lipids
JP5337722B2 (en) 2010-01-07 2013-11-06 ヤマハ発動機株式会社 Ship propulsion control device and ship
EP2706988B1 (en) * 2011-05-12 2019-12-04 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Liposomes comprising polymer-conjugated lipids and related uses

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395619A (en) * 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US20040241855A1 (en) * 1999-04-20 2004-12-02 The University Of British Columbia Cationic peg-lipids and methods of use
US20070185052A1 (en) * 2005-08-03 2007-08-09 Saul Yedgar Use of lipid conjugates in cystic fibrosis and applications thereof
US20100209490A1 (en) * 2007-08-09 2010-08-19 Daiichi Sankyo Company, Limited Immunoliposome inducing apoptosis into cell expressing death domain-containing receptor
WO2011017297A2 (en) * 2009-08-03 2011-02-10 The University Of North Carolina At Chapel Hill Biodegradable delivery system complexes for the delivery of bioactive compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOZAFARI ET AL.: "Nanoliposomes and their Applications in Food Nanotechnology.", J. LIPOSOME RES., vol. 18, no. 4, 2008, pages 309 - 327, XP055138102 *

Also Published As

Publication number Publication date
CN104023708A (en) 2014-09-03
US11911507B2 (en) 2024-02-27
CA2834918C (en) 2020-03-24
EP2706988A2 (en) 2014-03-19
US20200246265A1 (en) 2020-08-06
EP2706988A4 (en) 2015-06-17
WO2012153338A2 (en) 2012-11-15
US20190142751A1 (en) 2019-05-16
US20210338582A1 (en) 2021-11-04
JP2014519493A (en) 2014-08-14
DK2706988T3 (en) 2020-01-20
US10179106B2 (en) 2019-01-15
AU2012254842A1 (en) 2013-05-02
EP2706988B1 (en) 2019-12-04
CA2834918A1 (en) 2012-11-15
US20140199241A1 (en) 2014-07-17
ES2762224T3 (en) 2020-05-22
US10624851B2 (en) 2020-04-21

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