WO2012153216A1 - Procédé pour encapsuler et protéger des substances destinées à être mélangées avec un solvant avant l'utilisation - Google Patents

Procédé pour encapsuler et protéger des substances destinées à être mélangées avec un solvant avant l'utilisation Download PDF

Info

Publication number
WO2012153216A1
WO2012153216A1 PCT/IB2012/052025 IB2012052025W WO2012153216A1 WO 2012153216 A1 WO2012153216 A1 WO 2012153216A1 IB 2012052025 W IB2012052025 W IB 2012052025W WO 2012153216 A1 WO2012153216 A1 WO 2012153216A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
oil
active substance
capsules
powder
Prior art date
Application number
PCT/IB2012/052025
Other languages
English (en)
Inventor
Vanni Benedetti
Original Assignee
Biodue S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biodue S.P.A. filed Critical Biodue S.P.A.
Publication of WO2012153216A1 publication Critical patent/WO2012153216A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B29/00—Packaging of materials presenting special problems
    • B65B29/10—Packaging two or more different substances isolated from one another in the package but capable of being mixed without opening the package, e.g. forming packages containing a resin and hardener isolated by a frangible partition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B2220/00—Specific aspects of the packaging operation
    • B65B2220/14—Adding more than one type of material or article to the same package
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B25/00—Packaging other articles presenting special problems
    • B65B25/001—Packaging other articles presenting special problems of foodstuffs, combined with their conservation

Definitions

  • the present invention relates to a method for inserting in capsules and protecting substances to be mixed in a solvent before use.
  • the invention relates to inserting in single-dose capsules and protecting lactobacilli, even though the method can be used for substances having problems analogous to those of lactobacilli, with particular reference to their sensitivity to humidity.
  • vitamins Another example of substances that can be introduced in capsules using the method according to the invention is represented by vitamins, be they single vitamins or vitamin complexes, which can present risks of oxidation or have a critical behaviour in the presence of humidity.
  • packages in particular of a single-dose type, which comprise a container containing the solvent (generally a liquid), on which there is mounted a capsule, of varying kinds, normally made of plastic material.
  • a container containing the solvent (generally a liquid), on which there is mounted a capsule, of varying kinds, normally made of plastic material.
  • capsules which are provided with a reservoir in turn provided with a rupturable bottom; sliding inside the reservoir there is a cutter that possesses a cutter element which, following a pressure exerted thereupon, provokes the rupture of the rupturable bottom.
  • an active substance which, upon the rupture of the rupturable bottom of the external part of the reservoir, falls inside the container and is dissolved in the liquid contained in the container.
  • the capsule containing the active substance is first prepared and subsequently fitted onto the container.
  • the active substance is inserted internally of the capsule, which is subsequently closed, and possibly associated with a closure capsule, and is thus ready to be used in combination with the container containing the solvent.
  • the object of the present invention is to obviate these drawbacks by providing a method for inserting in a capsule active substances and protecting such substances from humidity which enables the disadvantages of the prior art to be eliminated.
  • One advantage of the present invention is that of providing a method that can be implemented with the capsules presently in use.
  • the method herein is used to fill capsules with substances, in particular lactobacilli in freeze-dried form, vitamins or vitamin complexes, which must be mixed, prior to use, in a solvent contained in a container such as, for example, a bottle or a vial; the method uses a capsule, in which there is inserted an active substance, and which, like the known capsules of this type, is provided with a reservoir that is superiorly open and provided with a rupturable bottom; coupled inside the reservoir there is a tubular cutter element which is closed at one end and provided with a cutter at the opposite end, which is open.
  • the above-described capsules of this type have long been known and can be used to implement the method herein.
  • the method of the invention comprises initially a step of introducing an active substance in powder form, in particular freeze-dried lactobacilli, vitamins or vitamin complexes, into the capsule; for reasons that will be better apparent below, this step takes place with the cutter positioned with the open part thereof turned upward; it is noted that the upward and downward positions are in relation to the ground, assumed as "downward". Subsequently one proceeds with a further step of introducing internally of the capsule an oil which, inside the capsule, comes into contact with the active substance; the above-described position of the cutter enables the oil, which is liquid, to be easily introduced from above by means of a simple filler that is associated with normal machines for filling capsules of this type.
  • the oil used is an oil which has a water percentage of less than 1%; for this purpose it has been verified, with particular reference to lactobacilli, that an edible oil such as sunflower oil can be conveniently used, although, depending on the characteristics of the active substance, edible oils having analogous characteristics or oils of a different nature can be used.
  • the proportions by weight between the oil and active substance are variable, with a weight of the oil which is from 2 to 8 times the weight of the powder of the active substance. Good results have been obtained with a proportion by weight of the oil which is 4 times the weight of the powder of the active substance.
  • a step of fitting the reservoir onto the cutter is performed in order to close the capsule.
  • the sequence of introduction of the substances into the capsule which, as said, is carried out by inserting, in order, the active substance powder and the oil in the cutter, allows the oil, when the capsule is closed and subsequently moved, to "wet” (or rather lubricate) the surfaces of contact between cutter and reservoir, thus providing a more secure barrier to humidity, which could migrate into the capsule through the contact area of such surfaces; the presence of oil also facilitates the sliding that takes place between the cutter and the reservoir at the time of use.
  • the method herein envisages that, after the filling and closure of the capsule, a step of lightly shaking the capsule is performed.
  • This step can be performed, for example, by using a vibrating system applied to the conveyor which conveys the packed capsule to the packaging line, or by means of a conveyor having a tortuous path that obliges the capsule to roll during conveyance.
  • This step has the purpose of forming inside the capsule not an emulsion (which would damage the product) but rather a suspension of the particles of the active substance in the oil; for this reason, only light movements of the capsule are necessary, easily obtainable with the above- described systems.
  • the oil will coat the individual particles of active substance and create a protection against any humidity that may penetrate inside the capsule, even if all of the systems of a known type, which try to prevent this event, do not fully achieve their purpose (as often occurs).
  • the mortality of the lactobacilli packed according to the method of the invention is, storage conditions and times obviously being equal, distinctly lower than the mortality of the lactobacilli packed according to traditional methods; to give an example, in some tests performed maintaining two packages obtained with the same capsules, one using traditional methods and one using the method herein, under the same storage conditions for an equal amount of time, the mortality went from 70- 80% (traditional method) to around 20% (method herein).
  • the method herein thus makes it possible, using capsules and machines of a known type, to obtain effective humidity protection for the active substance contained in the capsule.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

L'invention concerne un procédé pour encapsuler et protéger des substances destinées à être mélangées avec un solvant avant l'utilisation. Le procédé emploie des capsules connues comportant un réservoir et un élément de coupe et prévoit une étape d'introduction d'une substance active, telle que des lactobacilles lyophilisés, sous forme pulvérulente dans la capsule, une étape subséquente d'introduction à l'intérieur de la capsule, en contact avec la substance active, d'une quantité d'huile, ayant une teneur en eau inférieure à 1 %, selon un rapport en poids variable correspondant à environ 4 fois le poids de la substance active en poudre. La capsule ainsi remplie est ensuite soumise à une étape de légère agitation de façon à produire, à l'intérieur de la capsule, une suspension des particules de poudre dans l'huile.
PCT/IB2012/052025 2011-05-06 2012-04-23 Procédé pour encapsuler et protéger des substances destinées à être mélangées avec un solvant avant l'utilisation WO2012153216A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMO2011A000099 2011-05-06
IT000099A ITMO20110099A1 (it) 2011-05-06 2011-05-06 Metodo per inserire in capsule e proteggere sostanze da miscelare ad un solvente prima dell'uso

Publications (1)

Publication Number Publication Date
WO2012153216A1 true WO2012153216A1 (fr) 2012-11-15

Family

ID=44554500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/052025 WO2012153216A1 (fr) 2011-05-06 2012-04-23 Procédé pour encapsuler et protéger des substances destinées à être mélangées avec un solvant avant l'utilisation

Country Status (2)

Country Link
IT (1) ITMO20110099A1 (fr)
WO (1) WO2012153216A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322996A2 (fr) * 1987-12-31 1989-07-05 Borden, Inc. Denrées alimentaires cuites et emballées contenant de l'amidon
WO1993024024A1 (fr) * 1992-05-25 1993-12-09 Multiforsa Ag Combinaison de denrees alimentaires
WO2007085710A1 (fr) * 2006-01-27 2007-08-02 Nutrition Pharma Dispositif pour larguer une substance dans un contenant
US20100089790A1 (en) * 2008-10-14 2010-04-15 Mead Johnson Nutrition Company Nutritive Substance Delivery Container

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322996A2 (fr) * 1987-12-31 1989-07-05 Borden, Inc. Denrées alimentaires cuites et emballées contenant de l'amidon
WO1993024024A1 (fr) * 1992-05-25 1993-12-09 Multiforsa Ag Combinaison de denrees alimentaires
WO2007085710A1 (fr) * 2006-01-27 2007-08-02 Nutrition Pharma Dispositif pour larguer une substance dans un contenant
US20100089790A1 (en) * 2008-10-14 2010-04-15 Mead Johnson Nutrition Company Nutritive Substance Delivery Container

Also Published As

Publication number Publication date
ITMO20110099A1 (it) 2012-11-07

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