WO2012149562A3 - Selective anti-hla antibody removal device and methods of production and use thereof - Google Patents

Selective anti-hla antibody removal device and methods of production and use thereof Download PDF

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Publication number
WO2012149562A3
WO2012149562A3 PCT/US2012/035869 US2012035869W WO2012149562A3 WO 2012149562 A3 WO2012149562 A3 WO 2012149562A3 US 2012035869 W US2012035869 W US 2012035869W WO 2012149562 A3 WO2012149562 A3 WO 2012149562A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
removal device
production
mhc
selective anti
Prior art date
Application number
PCT/US2012/035869
Other languages
French (fr)
Other versions
WO2012149562A2 (en
Inventor
William H. Hildebrand
Rico Buchli
Curtis McMURTREY
Steven Cate
Original Assignee
The Board Of Regents Of The University Of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Oklahoma filed Critical The Board Of Regents Of The University Of Oklahoma
Priority to EP12777262.2A priority Critical patent/EP2702066A4/en
Priority to CN201280032403.3A priority patent/CN103857691A/en
Priority to CA2872003A priority patent/CA2872003C/en
Publication of WO2012149562A2 publication Critical patent/WO2012149562A2/en
Publication of WO2012149562A3 publication Critical patent/WO2012149562A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

An anti-MHC removal device includes a serologically active, soluble MHC moiety covalently coupled to a solid support. Methods of production include covalently coupling the serologically active, soluble MHC moiety to the solid support. Methods of use of the anti- MHC removal device include contacting a biological sample with the device so that antibodies specific for the MHC moiety are removed from the biological sample. The biological sample is then recovered.
PCT/US2012/035869 2011-04-29 2012-04-30 Selective anti-hla antibody removal device and methods of production and use thereof WO2012149562A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP12777262.2A EP2702066A4 (en) 2011-04-29 2012-04-30 Selective anti-hla antibody removal device and methods of production and use thereof
CN201280032403.3A CN103857691A (en) 2011-04-29 2012-04-30 Selective anti-hla antibody removal device and methods of production and use thereof
CA2872003A CA2872003C (en) 2011-04-29 2012-04-30 Selective anti-hla antibody removal device and methods of production and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161480865P 2011-04-29 2011-04-29
US61/480,865 2011-04-29

Publications (2)

Publication Number Publication Date
WO2012149562A2 WO2012149562A2 (en) 2012-11-01
WO2012149562A3 true WO2012149562A3 (en) 2013-03-14

Family

ID=47073124

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/035869 WO2012149562A2 (en) 2011-04-29 2012-04-30 Selective anti-hla antibody removal device and methods of production and use thereof

Country Status (4)

Country Link
EP (1) EP2702066A4 (en)
CN (1) CN103857691A (en)
CA (1) CA2872003C (en)
WO (1) WO2012149562A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080038282A1 (en) * 2006-07-25 2008-02-14 Proimmune Limited Biotinylated MHC complexes and their uses
US20080057521A1 (en) * 2000-03-17 2008-03-06 Barnardo Martin C Method
US20090011437A1 (en) * 2007-07-03 2009-01-08 One Lambda Methods of Detecting Antibodies Specific for Denatured HLA Antigens
US20090182131A1 (en) * 2001-12-18 2009-07-16 Hildebrand William H Methods for removing anti-MHC antibodies from a sample

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080145872A1 (en) * 1999-12-17 2008-06-19 Hildebrand William H Expression of HLA proteins on non human cells
US8088586B2 (en) * 2000-03-17 2012-01-03 Oxford Radcliffe Hospital Nhs Trust Method of producing a body fluid sample depleted of anti-MHC antibodies
WO2008088837A2 (en) * 2007-01-17 2008-07-24 The Board Of Regents Of The University Of Oklahoma Expression of hla proteins on non-human cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080057521A1 (en) * 2000-03-17 2008-03-06 Barnardo Martin C Method
US20090182131A1 (en) * 2001-12-18 2009-07-16 Hildebrand William H Methods for removing anti-MHC antibodies from a sample
US20080038282A1 (en) * 2006-07-25 2008-02-14 Proimmune Limited Biotinylated MHC complexes and their uses
US20090011437A1 (en) * 2007-07-03 2009-01-08 One Lambda Methods of Detecting Antibodies Specific for Denatured HLA Antigens

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2702066A4 *

Also Published As

Publication number Publication date
WO2012149562A2 (en) 2012-11-01
CA2872003A1 (en) 2012-11-01
CN103857691A (en) 2014-06-11
EP2702066A2 (en) 2014-03-05
CA2872003C (en) 2021-08-10
EP2702066A4 (en) 2014-12-31

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