EP2702066A4 - Selective anti-hla antibody removal device and methods of production and use thereof - Google Patents

Selective anti-hla antibody removal device and methods of production and use thereof

Info

Publication number
EP2702066A4
EP2702066A4 EP12777262.2A EP12777262A EP2702066A4 EP 2702066 A4 EP2702066 A4 EP 2702066A4 EP 12777262 A EP12777262 A EP 12777262A EP 2702066 A4 EP2702066 A4 EP 2702066A4
Authority
EP
European Patent Office
Prior art keywords
production
methods
removal device
selective anti
hla antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12777262.2A
Other languages
German (de)
French (fr)
Other versions
EP2702066A2 (en
Inventor
William H Hildebrand
Rico Buchli
Curtis Mcmurtrey
Steven Cate
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
Original Assignee
University of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Publication of EP2702066A2 publication Critical patent/EP2702066A2/en
Publication of EP2702066A4 publication Critical patent/EP2702066A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP12777262.2A 2011-04-29 2012-04-30 Selective anti-hla antibody removal device and methods of production and use thereof Withdrawn EP2702066A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161480865P 2011-04-29 2011-04-29
PCT/US2012/035869 WO2012149562A2 (en) 2011-04-29 2012-04-30 Selective anti-hla antibody removal device and methods of production and use thereof

Publications (2)

Publication Number Publication Date
EP2702066A2 EP2702066A2 (en) 2014-03-05
EP2702066A4 true EP2702066A4 (en) 2014-12-31

Family

ID=47073124

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12777262.2A Withdrawn EP2702066A4 (en) 2011-04-29 2012-04-30 Selective anti-hla antibody removal device and methods of production and use thereof

Country Status (4)

Country Link
EP (1) EP2702066A4 (en)
CN (1) CN103857691A (en)
CA (1) CA2872003C (en)
WO (1) WO2012149562A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017447A1 (en) * 2000-03-17 2003-01-23 Barnardo Martin C Method
US20040191245A1 (en) * 2000-03-17 2004-09-30 Barnardo Martin C M M Method
EP1882700A1 (en) * 2006-07-25 2008-01-30 Prolmmune Limited Biotinylated MHC complexes and their uses
US20080145872A1 (en) * 1999-12-17 2008-06-19 Hildebrand William H Expression of HLA proteins on non human cells
WO2008088837A2 (en) * 2007-01-17 2008-07-24 The Board Of Regents Of The University Of Oklahoma Expression of hla proteins on non-human cells
US20090182131A1 (en) * 2001-12-18 2009-07-16 Hildebrand William H Methods for removing anti-MHC antibodies from a sample

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009006312A1 (en) * 2007-07-03 2009-01-08 One Lambda Methods of detecting antibodies specific for denatured hla antigens

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080145872A1 (en) * 1999-12-17 2008-06-19 Hildebrand William H Expression of HLA proteins on non human cells
US20030017447A1 (en) * 2000-03-17 2003-01-23 Barnardo Martin C Method
US20040191245A1 (en) * 2000-03-17 2004-09-30 Barnardo Martin C M M Method
US20090182131A1 (en) * 2001-12-18 2009-07-16 Hildebrand William H Methods for removing anti-MHC antibodies from a sample
EP1882700A1 (en) * 2006-07-25 2008-01-30 Prolmmune Limited Biotinylated MHC complexes and their uses
WO2008088837A2 (en) * 2007-01-17 2008-07-24 The Board Of Regents Of The University Of Oklahoma Expression of hla proteins on non-human cells

Also Published As

Publication number Publication date
WO2012149562A3 (en) 2013-03-14
EP2702066A2 (en) 2014-03-05
WO2012149562A2 (en) 2012-11-01
CN103857691A (en) 2014-06-11
CA2872003A1 (en) 2012-11-01
CA2872003C (en) 2021-08-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20131128

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20141127

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 16/06 20060101ALI20141121BHEP

Ipc: C07K 14/74 20060101ALI20141121BHEP

Ipc: C12M 1/00 20060101ALI20141121BHEP

Ipc: C07K 1/22 20060101AFI20141121BHEP

Ipc: C07K 16/28 20060101ALI20141121BHEP

Ipc: C12N 15/13 20060101ALI20141121BHEP

17Q First examination report despatched

Effective date: 20170623

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20180104