WO2012140276A9 - Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts - Google Patents

Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts Download PDF

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Publication number
WO2012140276A9
WO2012140276A9 PCT/EP2012/066154 EP2012066154W WO2012140276A9 WO 2012140276 A9 WO2012140276 A9 WO 2012140276A9 EP 2012066154 W EP2012066154 W EP 2012066154W WO 2012140276 A9 WO2012140276 A9 WO 2012140276A9
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
calcium salts
methylbutyric acid
preparation
ketene
Prior art date
Application number
PCT/EP2012/066154
Other languages
French (fr)
Other versions
WO2012140276A2 (en
WO2012140276A3 (en
Inventor
Christian Noti
Leo Schmid
Bruno Rittiner
Paul Hanselmann
Anja Bierstedt
Original Assignee
Lonza Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ltd filed Critical Lonza Ltd
Publication of WO2012140276A2 publication Critical patent/WO2012140276A2/en
Publication of WO2012140276A3 publication Critical patent/WO2012140276A3/en
Publication of WO2012140276A9 publication Critical patent/WO2012140276A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Abstract

A new process for preparing calcium salts of 3-hydroxy-3-methylbutyric acid is described. Lactones obtained from ketene and acetone are hydrolyzed in selective and scalable manners. The 3-hydroxy-3-methylbutyric acid or its calcium salts are useful in preparations for inhibiting protein depletion or as immuno-stimulating feedstuff additives for mammals.
PCT/EP2012/066154 2011-11-17 2012-08-19 Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts WO2012140276A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161560877P 2011-11-17 2011-11-17
US61/560,877 2011-11-17
EP11189552 2011-11-17
EP11189552.0 2011-11-17
EP12180947.9 2012-08-18
EP12180947 2012-08-18

Publications (3)

Publication Number Publication Date
WO2012140276A2 WO2012140276A2 (en) 2012-10-18
WO2012140276A3 WO2012140276A3 (en) 2013-01-10
WO2012140276A9 true WO2012140276A9 (en) 2013-07-11

Family

ID=47009756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/066154 WO2012140276A2 (en) 2011-11-17 2012-08-19 Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts

Country Status (1)

Country Link
WO (1) WO2012140276A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7306202B2 (en) * 2018-10-15 2023-07-11 Jnc株式会社 Method for producing aliphatic carboxylic acid compound, and pyridine compound adduct of aliphatic ketone compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992470A (en) * 1990-02-08 1991-02-12 Iowa State University Research Foundation, Inc. Method of enhancing immune response of mammals
EP0660706B1 (en) * 1992-09-16 1999-12-29 Iowa State University Research Foundation, Inc. Method of reducing blood levels of total cholesterol and low-density lipoprotein cholesterol
US6090978A (en) * 1996-07-19 2000-07-18 Met-Rx Usa, Inc. Process for manufacturing 3-hydroxy-3-methylbutanoic acid
WO1998034897A1 (en) * 1997-02-10 1998-08-13 Lonza Ag Process for preparing 3-hydroxy-3-methylbutyric acid or its salts
CZ302823B6 (en) * 2001-05-18 2011-11-30 Lonza Ag Process for preparing solid forms of sodium 3-hydroxy-3-methyl-butyrate
CN1417190A (en) * 2002-12-05 2003-05-14 迈特（上海）生物科技有限公司 Prepn process of beta-hydroxyl-beta-methyl butyric calcium (HMB-Ca)

Also Published As

Publication number Publication date
WO2012140276A2 (en) 2012-10-18
WO2012140276A3 (en) 2013-01-10

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