WO2012131714A1 - Compositions à base de plantes pour utilisation vétérinaire et médicaments associés - Google Patents

Compositions à base de plantes pour utilisation vétérinaire et médicaments associés Download PDF

Info

Publication number
WO2012131714A1
WO2012131714A1 PCT/IN2012/000208 IN2012000208W WO2012131714A1 WO 2012131714 A1 WO2012131714 A1 WO 2012131714A1 IN 2012000208 W IN2012000208 W IN 2012000208W WO 2012131714 A1 WO2012131714 A1 WO 2012131714A1
Authority
WO
WIPO (PCT)
Prior art keywords
leaves
followed
predefined amount
sieving
juice
Prior art date
Application number
PCT/IN2012/000208
Other languages
English (en)
Other versions
WO2012131714A4 (fr
Inventor
Petharajanna
Original Assignee
Petharajanna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Petharajanna filed Critical Petharajanna
Publication of WO2012131714A1 publication Critical patent/WO2012131714A1/fr
Publication of WO2012131714A4 publication Critical patent/WO2012131714A4/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Definitions

  • the present invention relates to veterinary herbal compositions and medicaments thereof.
  • the invention relates to the veterinary herbal compositions and medicaments thereof; for treatment of ephemeral fever.
  • Bovine ephemeral fever is an acute, arthropod-borne disease of cattle. The disease is characterized by sudden onset of fever, stiffness and disinclination to movement accompanied by lameness, high morbidity and very low mortality. Recovery usually occurs within three to four days of the onset of clinical signs. Although mortality is usually low, cattle in good condition are usually affected more severely; mortality rates can be higher than 30% in very fat cattle.
  • Bovine ephemeral fever is a viral disease of cattle and buffaloes besides subclinical involvement of a variety of ruminant species. The clinical severity of the disease is not apparent and the mortality is low. However, it can cause significant economic impact through reduced milk production in dairy herds, loss of condition in beef cattle, loss of draught animals at the time of harvest, abortion, temporary infertility in bulls, and prolonged recovery in some animals as well as trade restrictions. Available evidence indicates clinical signs of BEF, which include biphasic fever, anorexia, muscle stiffness, ocular and nasal discharge, ruminal statis and recumbency, are due primarily to a vascular inflammatory response. Recovery usually occurs within three to four days, hence the term ephemeral. The causative virus is transmitted by haematophagous insects that appear to be borne on the wind, allowing rapid spread of the disease. LS/NIF/03 2
  • bovine ephemeral fever The vector for bovine ephemeral fever is not proven, but the disease appears to be spread mainly by mosquitoes.
  • Ephemeral fever virus has been isolated from Culex and Anopheles mosquitoes in Australia, and from Culicoides biting midges in Africa and Australia. The timing of outbreaks supports mosquitoes as a vector.
  • the disease can also be spread by intravenous inoculation of small amounts of blood.
  • Bovine ephemeral fever is not transmitted by close contact, bodily secretions, or aerosol droplets. The virus does not seem to be transmitted in semen and is rapidly inactivated in meat. Carriers are not known to occur. The prevalence, geographic range, and severity of the disease vary from year to year, and epidemics occur periodically.
  • Ephemeral fever is most prevalent in the wet season in the tropics and in summer to early autumn in the subtropics or temperate regions (when conditions favor multiplication of biting insects); it disappears abruptly in winter. Morbidity may be as high as 80%; overall mortality is usually 1-2%, although it can be higher in lactating cows, bulls in good condition, and fat steers (10-30%).
  • Ephemeral fever is one of the rare virus diseases for which treatment is effective.
  • the inflammatory nature of the disease process means it is responsive to anti-inflammatory drugs. These drugs must be given for the expected course of the clinical disease. Also, relapses occur in ephemeral fever if anti-inflammatory treatment is discontinued too early.
  • Chinese Patent publication no CN 101829285 discloses Chinese medicine for treating bovine ephemeral fever and the application method thereof.
  • the medicament formula comprises of honeysuckle flowers, houttuynia cordata, bamboo leaves, common andrographis herbs, gardenia, Chinese rhubarb powder, licorice powder.
  • Herbal medicines are the most affordable treatment that poor people from remote places can have access to. This is the main reason why herbal drugs are widely used in primary healthcare in treating the rural populations. In this scenario, Herbal drugs can play a meaningful role in the treatment of a number of diseases.New solutions are becoming the need of the hour for treatment of Filariasis.
  • An object of the invention is to provide veterinary herbal composition and medicament thereof for treatment of ephemeral fever.
  • Another object of the invention is to provide veterinary herbal composition and medicament thereof for treatment of ephemeral fever; said composition and medicament comprising Acalypha indica, Azima tetracantha, Brassica juncea, Albizzia lebbeck and Aegle marmelo.
  • Yet another object of the invention is to provide veterinary herbal composition and medicament thereof for treatment of ephemeral fever; said medicament may be administered orally or topically or injected intravenously, subcutaneously, etc or by any other suitable route of administration.
  • Still another object of the invention is to provide veterinary herbal composition and medicament thereof for treatment of ephemeral fever; wherein said composition and medicament is efficient and economic.
  • An additional object of the invention is to provide veterinary herbal composition and medicament thereof for treatment of ephemeral fever; wherein said composition and medicament shows enhanced efficacy.
  • Another additional object of the invention is to provide veterinary herbal composition and medicament thereof for treatment of ephemeral fever; wherein said composition and medicament shows high safety to host substantially without side effects.
  • Yet another additional object of the invention is to provide method of treatment for ephemeral fever by using the said herbal composition and medicament thereof which is more efficient and helps to eradicate the diseases substantially.
  • Embodiments of the invention are not mutually exclusive, but may be implemented in various combinations.
  • the described embodiments of the invention and the disclosed examples are given for the purpose of illustration rather than limitation of the invention as set forth the appended claims. Further the terms disclosed LS/NIF/03 5
  • the herbal composition and medicament thereof of the present invention is simple, natural, attractive and convenient to use.
  • the manufacture method for herbal medicine is simple and the effect is excellent; the price is low.
  • the herbal composition and medicament thereof is useful in the treatment of the field of veterinary.
  • Acalypha indica (Tamil: Kuppaimeni) is a species of plant. It occurs throughout tropical Africa and South Africa, in India and Sri Lanka, as well as in Yemen and Pakistan. It has possibly been introduced elsewhere as a weed. In West and East Africa the plant is used as a medicinal plant. In West Africa the leaves are cooked and eaten as a vegetable. It is also browsed by cattle. This plant is held in high esteem in traditional Tamil Siddha medicine as it is believed to rejuvenate the body.
  • Azima tetracantha belonging to the family Salvadoraccae is Spiny scrambling shrub. Azima tetracantha occurs naturally in central, eastern and southern Africa as well as in the Indian Ocean islands, and extends through Arabia to tropical Asia. Azima tetracantha appears to be limited and only occasional in Africa. The fruit is edible. Azima tetracantha is browsed by livestock. It is planted as live fence in Bangalore (India). In Malaysia pickled leaves are used as an appetizer and against colds. As all parts containing glucosinolates, further research on LS/NIF/03 6 medicinal applications is warranted. The plant is promoted as an ornamental in the United States.
  • Brassica juncea also known as Mustard, Leaf mustard, Indian mustard, Sarson belongs to the family Brassicaceae.
  • mustard seeds There are two varieties of mustard seeds; one is black mustard and the other is white mustard, which are used for medicinal purpose as well as food, since centuries.
  • Ayurvedic Samhita has vividly described the properties and medicinal uses of these two varieties separately. Though they are two separate herbs, more or less, their properties are similar.
  • Charaka has categorized the white variety as asthapanopaga ie adjunct to decoction enemas and the black variety as kandughna ie antipruritic. The plant is cultivated throughout India, especially in Bihar, Bengal and Bengal Pradesh. It is a large branching annual, growing up to 0.6-1 meter in height.
  • the leaves are broadly ovate, coarsely dentate, the lowest ones lyrate and slightly hispid whereas, the upper ones lanceolate, all stalked, dark green in colour.
  • the flowers are in corymbose racemes, stalked, bright yellow.
  • the seeds are brownish-red, tiny.
  • Albizzia comprises approximately 150 species, mostly trees and shrubs native to tropical and subtropical regions of Asia and Africa (Allen and Allen 1981 , National Research Council 1979).
  • Albizzia lebbeck is native to deciduous and semi deciduous forests in Asia from eastern Pakistan through India and Sri Lanka to Burma. The tree has been introduced as an ornamental and plantation tree throughout the tropics and northern subtropics, including the Greater and Lesser Antilles, Central America, Colombia, Venezuela, and Brazil (Adams 1972, Grisebach 1864, Hutchinson and Dalziel 1958, Little and Wadsworth 1964).
  • Albizzia lebbeck is a fast-growing, medium-sized deciduous tree with a spreading umbrella-shaped crown of thin foliage and smoothish, finely fissured, grayish-brown bark.
  • Bael (Aegle marmelos) belongs to Rutaceae family.
  • the bael is a large tree, 8 to 10 meters in height. It has a big stout trunk, unusual branches with long, straight outgrowth, aromatic leaves, and sweet scented and greenish-white flowers.
  • the fruit is woody and smooth, 5 to 15 cm in diameter. It has numerous seeds which are densely covered with fibrous hair and are embedded in a thick aromatic pulp. The flesh is eaten fresh or dried.
  • Bael tree is held sacred by the Malawis. The history of this tree has been traced to Vedic period (2000 B.C. 800 B.C.).
  • the mention of bael fruit has been made in Yajurveda.
  • the bael tree has great mythological LS/NIF/03 7 significance and abounds in the vicinity of temples.
  • the bael tree is indigenous to India and is grown throughout the sub-continent as well as most countries of South-east Asia.
  • the scope of the present invention comprises use of different parts of Acalypha indica, Azima tetracantha, Brassica juncea, Albizzia lebbeck and Aegle marmelos to prepare the composition and medicament comprising the same.
  • herbal composition for treatment of ephemeral fever there is provided herbal composition for treatment of ephemeral fever
  • composition comprising predefined amount of Acalypha indica; predefined amount of Azima tetracantha; predefined amount of Brassica juncea; predefined amount of Albizzia lebbeck and predefined amount of Aegle marmelos.
  • the said herbal composition comprising 70% to 80% of Acalypha indica, 10%) to 20%) of Azima tetracantha, 1% to 5% of Brassica (juncea, 10% to 15% Albizzia lebbeck and 1% to 5% of Aegle marmelos. All percentages are percent by weight of the mixture.
  • leaves of Acalypha indica are used in the herbal composition of the invention.
  • leaves of Azima tetracantha are used in the herbal composition of the invention.
  • leaves of Brassica juncea are used in the herbal composition of the invention.
  • 1%> to 5% of the leaves of Brassica juncea are used in the herbal composition of the invention.
  • leaves of Albizzia lebbeck are used in the herbal composition of the invention.
  • leaves of Aegle marmelos are used in the herbal composition of the invention.
  • 1% to 5% of the leaves of Aegle marmelos are used in the herbal composition of the invention.
  • the said herbal composition is used in the treatment of ephemeral fever.
  • the composition is found to be efficient and showed enhanced efficacy against ephemeral fever in animals.
  • said method comprises;
  • the method optionally comprises:
  • the composition may comprises the extract like a whole plant extract, a rhizome extract, a leaf extract, a seed extract, a root extract, a bark extract, a flower extract, a fruit extract, and a combination thereof.
  • the extract is generally prepared in a solvent, typically water, alcohol or combination thereof. However, other solvents and solutions compatible with plant usage and habitat may also be used.
  • a mixture of water and alcohol used for extraction is in the proportion of 60:40.
  • the 50 ml of either water or alcohol or the mixture of water and alcohol is used for the extraction.
  • the extraction can be carried out in a temperature controlled extraction vessel at a temperature between 50°C to 70°C. Preferably, the extraction can be carried out at controlled temperature between 55°C to 65°C.
  • the method optionally comprises:
  • step (n) sieving followed by washing and sieving again predefined amount of leaves of Acalypha indica, predefined amount of leaves oiAzima tetracantha, predefined amount of leaves of Brassica juncea, predefined amount of leaves of Albizzia lebbeck and predefined amount of leaves of Aegle marmelos followed by drying and making paste or juice of them together by conventional means to obtain synergistic composition; and o. extracting the composition obtained in step (n) with solvent at controlled temperature between 50°C to 70°C at controlled temperature between 50°C to 70°C.
  • the extraction steps (h), (i), (j), (k), (1) and (o) are carried out in a temperature controlled extraction vessel.
  • the steps (h), (i), (j), (k), (1) and (o) are carried out at controlled temperature between 55°C to 65°C.
  • the solvent used for the extraction is water, alcohol like ethanol or methanol or combination thereof. However, other solvents and solutions compatible with plant usage and habitat may also be used. A mixture of water and alcohol used for extraction is in the proportion of 60:40. LS/NIF/03 11
  • the 50 ml of either water or alcohol or the mixture of water and alcohol is used for the extraction.
  • step (m) and (o) is converted into semi solid or solid dosage form by conventional means which includes but is not limited to using vacuum rotary evaporator, lyophilization or the like.
  • all ingredients are thoroughly washed and sieved prior to making paste and extraction.
  • the components are first thoroughly washed and dried well. Thereafter they are sieved to remove remaining impurities and preferably, washed again with sterile water.
  • composition of the present invention based on the above herbs acts as a synergistic composition having unexpected and new properties in the treatment of ephemeral fever.
  • the combination of above-mentioned components in the treatment of ephemeral fever is therefore, truly inventive and non obvious.
  • herbal medicament for the treatment of ephemeral fever there is provided herbal medicament for the treatment of ephemeral fever
  • said medicament comprising predefined amount of composition of the invention along with either suitable pharmaceutically acceptable excipient, vehicle and / or adjuvant suitable for administering orally or topically or injectable including intravenous, subcutaneous, etc or intramuscular, by any other suitable route of administration.
  • the said herbal medicament comprising 70% to 80% of Acalypha indica, 10% to 20% of Azima tetracantha, 1% to 5% of Brassica juncea, 10% to 15% Albizzia lebbeck and 1% to 5% of Aegle marmelos. All percentages are percent by weight of the mixture.
  • the said herbal medicaments are used in the treatment of ephemeral fever and found to be efficient and with enhanced efficacy against ephemeral fever in both human and animals.
  • said method comprises:
  • step (vi) optionally adding either suitable excipient, vehicle or adjuvant to the composition obtained in step (vi);
  • step (vi) or (vii) converting the composition obtained in step (vi) or (vii) into medicament by conventional method;
  • said medicament for administering orally or topically or injectable including intravenous, subcutaneous, etc or by any other suitable route of administration.
  • the method optionally comprises :
  • step (ix) optionally adding either suitable excipient, vehicle or adjuvant to the composition obtained in step (ix); and LS/NIF/03 13 xi. converting the composition obtained in step (ix) or (x) into medicament by conventional method;
  • said medicament for administering orally or topically or injectable including intravenous, subcutaneous, etc or by any other suitable route of administration.
  • the said herbal medicament comprising 70% to 80%> of Acalypha indica, 10%> to 20% oiAzima tetracantha, 1%> to 5%> of Brassica juncea, 10%> to 15%> Albizzia lebbeck and 1%> to 5% of Aegle marmelos. All percentages are percent by weight of the mixture.
  • the method optionally comprises :
  • xvii mixing all extracts obtained in steps (xii), (xiii), (xiv), (xv) and (xvi) together to obtain synergistic composition; LS/NIF/03 14 xviii. optionally adding either suitable excipient, vehicle or adjuvant to the composition obtained in step (xvii);
  • said medicament for administering orally or topically or injectable including intravenous, subcutaneous, etc or by any other suitable route of administration.
  • the method optionally comprises :
  • step (xxi) extracting the paste or juice obtained in step (xx) with solvent at controlled temperature between 50°C to 70 °C followed by converting the extract into semi solid or solid form to obtain synergistic composition;
  • said medicament for administering orally or topically or injectable including intravenous, subcutaneous, etc or by any other suitable route of administration.
  • the said herbal medicament comprising 70% to 80% of Acalypha indica, 10%) to 20% of Azima tetracantha, l% to 5% of Brassica juncea, 10%) to 15% Albizzia lebbeck and 1%> to 5% of Aegle marmelos. All percentages are percent by weight of the mixture.
  • the extraction steps (xii), (xiii), (xiv), (xv), (xvi) and (xx) are carried out in a temperature controlled extraction vessel.
  • the steps (xii), (xiii), (xiv), (xv), (xvi) and (xx) are carried out at controlled temperature between 55°C to 65°C.
  • the solvent used for extraction in step (xii), (xiii), (xiv), (xv), (xvi) and (xx) is alcohol like methanol, ethanol, water or mixture thereof. 50 ml of either water or alcohol or the mixture of LS/NIF/03 15 water and alcohol is used for the extraction. A mixture of water and alcohol used for extraction is in the proportion of 60:40.
  • the extracts so obtained as above can be converted into semi solid or solid form composition by conventional method like rotary evaporation, lyophilization, etc.
  • the said medicament can be administered orally or topically or injected intravenously, subcutaneously, etc or by any other suitable route of administration.
  • the herbal medicament may be in the form including but not limited to tinctures, herbal wine, elixirs, tisanes, decoctions, powder, juice, syrup, tablets, granules, capsules, etc.
  • the herbal medicament may be in the form including but not limited to oils, salves, balms, cream, lotion, spray, poultices, compresses, etc.
  • the herbal medicament may be in the form including but not limited to bolus, intravenous injection, subcutaneous injection, intramuscular injection, intrathecal, etc.
  • Tinctures are alcoholic extracts of herbs; usually obtained by combining 100% pure ethanol (or a mixture of 100% ethanol with water) with the herb.
  • a completed tincture has ethanol percentage of at least 25% (sometimes up to 90%).
  • the term tincture is sometimes applied to preparations using other solvents than ethanol.
  • Herbal wine and elixirs are alcoholic extract of herbs; usually with an ethanol percentage of 12-38%.
  • Herbal wine is a maceration of herbs in wine, while an elixir is a maceration of herbs in spirits (e.g., vodka, grappa, etc.).
  • Tisanes are hot water extracts of herb.
  • Decoctions are long-term boiled extract of herb. LS/NIF/03 16
  • Powder and Juices In this whole herb is consumed either in dried form (herbal powder), or fresh juice, (fresh leaves and other plant parts).
  • Salves, oils, balms, creams and lotions Most topical applications are oil extractions of herbs. Taking a food grade oil and soaking herbs in it for anywhere from weeks to months allows certain photochemicals to be extracted into the oil. This oil can then be made into salves, creams, lotions, or simply used as oil for topical application.
  • Poultices and compresses The whole herb (or the appropriate part of the plant) usually crushed or dried and re-hydrated with a small amount of water and then applied directly in a bandage, cloth or just as is.
  • a fresh herb paste can be applied at affected site.
  • Injectable form It can also be prepared in the injectable form
  • Bolus is a large time-release tablet that stays in the rumen of cattle, goats and sheep, etc.
  • bolus can be administered intravenous injection, subcutaneous injection, intramuscular injection, intrathecal, etc.
  • said treatment comprises administration of said herbal medicament of the invention either orally or topically or injectable including intravenous, subcutaneous, etc or by any other suitable route of administration.
  • the medicaments may be continued for until the symptoms of the disease get cured.
  • the herbal composition and medicament thereof of the invention is found to be efficient for treatment of ephemeral fever. It was prepared from the herbs which are available at cheaper price, thereby making the composition and medicament economic.
  • the composition and medicament found to enhance efficacy as compared to that of individual use of Acalypha LS/NIF/03 17 indica, Azima tetracantha, Brassica juncea, Albizzia lebbeck and Aegle marmelos.
  • the composition was found to be substantially without side effects.
  • Leaves of Acalypha indica (525 gm), Azima tetracantha (75 gm), Brassica juncea (30 gm), Albizzia lebbeck (90gm) and Aegle marmelos (30 gm) were sieved, washed and sieved followed by drying separately.
  • the leaves of Acalypha indica (525gm), Azima tetracantha (75gm), Brassica juncea (30 gm), Albizzia lebbeck (90 gm) and Aegle marmelos (30 gm) were LS/NIF/03 18 grounded separately to get individual pastes.
  • the pastes so obtained was mixed and converted into bolus by conventional means.
  • the bolus was administered on crossbred cattle infected with the ephemeral fever.
  • the dosage given is 1 bolus 250g per day for 3 days.
  • Leaves of Acalypha indica (525gm), Azima tetracantha (75 gm), Brassica juncea (30 gm), Albizzia lebbeck (90 gm) and Aegle marmelos (30 gm) were sieved, washed and sieved followed by drying separately.
  • the leaves of Acalypha indica (525 gm), Azima tetracantha 75 gm), Brassica juncea 30 gm), Albizzia lebbeck (90 gm) and Aegle marmelos (30gm) were grounded separately to get individual pastes.
  • the pastes so obtained were individually extracted with 50 ml mixture of water and alcohol in the ratio of 60: 40 at 60°C.
  • Leaves of Acalypha indica (525 gm) were sieved, washed and sieved followed by drying. The leaves were grounded to get the smooth paste. The paste was further converted into bolus by conventional means and was administered on crossbred cattle infected with the ephemeral fever. The dosage given is 1 bolus of 250gm per day for 5 days. It was observed that the crossbred cattle was relieved in 5 days.
  • Leaves of Brassica juncea (30 gm) were sieved ⁇ washed and sieved followed by drying. The leaves were grounded to get the smooth paste.
  • the paste was further converted into bolus by conventional means and was administered on Crossbred cattle infected with the ephemeral fever. The dosage given is 1 bolus of 250g day for 4 days. It was observed that the Crossbred - was relieved in 4 days.
  • Leaves of Aegle marmelos (30 gm) were sieved, washed and sieved followed by drying. The leaves were grounded to get the smooth paste.
  • the paste was further converted into bolus by conventional means and was administered on Crossbred cattle infected with the ephemeral fever. The dosage given is 1 bolus 250g per day for 6 days. It was observed that the Crossbred cattle was relieved in 6 days.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une composition à base de plantes pour traiter la fièvre éphémère, laquelle composition comprend de l'Acalypha indica, de l'Azima tetracantha, de la Brassica juncea, de l'Albizzia lebbeck et du marmelos d'Aegle. L'invention concerne également le procédé permettant de préparer ladite composition. L'invention concerne également la méthode de préparation de ladite composition. L'invention concerne également un médicament comprenant ladite composition et un procédé permettant de préparer ce médicament.
PCT/IN2012/000208 2011-03-31 2012-03-28 Compositions à base de plantes pour utilisation vétérinaire et médicaments associés WO2012131714A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1033/CHE/2011 2011-03-31
IN1033CH2011 2011-03-31

Publications (2)

Publication Number Publication Date
WO2012131714A1 true WO2012131714A1 (fr) 2012-10-04
WO2012131714A4 WO2012131714A4 (fr) 2012-11-22

Family

ID=46149700

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000208 WO2012131714A1 (fr) 2011-03-31 2012-03-28 Compositions à base de plantes pour utilisation vétérinaire et médicaments associés

Country Status (1)

Country Link
WO (1) WO2012131714A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104922284A (zh) * 2015-05-25 2015-09-23 毛艳玲 一种埃博拉病毒的抑制药剂
CN105232695A (zh) * 2015-10-13 2016-01-13 林庆华 一种治疗痄腮的中药制剂及护理方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101829285A (zh) 2010-03-30 2010-09-15 张小栋 一种治疗牛流行性热的中药药物配方及其使用方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101829285A (zh) 2010-03-30 2010-09-15 张小栋 一种治疗牛流行性热的中药药物配方及其使用方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AMBIKA NAG ET AL: "Indigenous animal healthcare practices from Udaipur district, Rajasthan", INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE, RESOURCES, NEW DELHI, NEW DELHI - INDIA, vol. 6, no. 4, 1 October 2007 (2007-10-01), pages 583 - 588, XP018024099, ISSN: 0972-5938 *
DATABASE WPI Derwent World Patents Index; AN 2011-N21616, XP002680655, "Herbal composition for treatment of ephemeral fever" *
GANESAN* S ET AL: "Ethnoveterinary healthcare practices in southern districts of Tamil Nadu", INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE, RESOURCES, NEW DELHI, NEW DELHI - INDIA, vol. 7, no. 2, 1 April 2008 (2008-04-01), pages 347 - 354, XP018024000, ISSN: 0972-5938 *
UPADHYAY B ET AL: "Ethno-veterinary uses and informants consensus factor of medicinal plants of Sariska region, Rajasthan, India", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER SCIENTIFIC PUBLISHERS LTD, IE, vol. 133, no. 1, 7 January 2011 (2011-01-07), pages 14 - 25, XP027575265, ISSN: 0378-8741, [retrieved on 20101224] *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104922284A (zh) * 2015-05-25 2015-09-23 毛艳玲 一种埃博拉病毒的抑制药剂
CN105232695A (zh) * 2015-10-13 2016-01-13 林庆华 一种治疗痄腮的中药制剂及护理方法

Also Published As

Publication number Publication date
WO2012131714A4 (fr) 2012-11-22

Similar Documents

Publication Publication Date Title
Akinpelu et al. Anacardium occidentale
Sabandar et al. Medicinal property, phytochemistry and pharmacology of several Jatropha species (Euphorbiaceae): a review
Sharafzadeh et al. German and Roman chamomile
KR20100042337A (ko) 류머티스관절염 치료제 생약제 조성물 및 그 치료제 제조방법
JP4393777B2 (ja) 抗ヘリコバクター・ピロリ用組成物
Zaurov et al. The medicinal plants of Uzbekistan and Kyrgyzstan
Mallik et al. Pharmacological activity of Cucumis sativus L.–a complete overview
Kanu et al. A review of the multifaceted usefulness of Celosia argentea Linn
KR100867514B1 (ko) 지초 비누의 제조방법
Ansari et al. Therapeutics and pharmacology of Gul-e-Surkh (Rosa damascena Mill): An important Unani drug
Kozak et al. Health properties of selected herbal plants
Seriki et al. Analysis of phytoconstituents of Desmodium adscendens in relation to its therapeutic properties
Ugbabe et al. Preliminary phytochemical, antimicrobial and acute toxicity studies of the stem, bark and the leaves of a cultivated Syzygium cumini Linn.(Family: Myrtaceae) in Nigeria
WO2012131714A1 (fr) Compositions à base de plantes pour utilisation vétérinaire et médicaments associés
WO2012032494A1 (fr) Composition contenant un extrait de matériel végétal de figuier et son utilisation dans le traitement de l'hyperplasie bénigne de la prostate
Verma et al. Some important medicinal plants of cold desert regions of District Kinnaur of Himachal Pradesh state in India: Their uses and chemical ingredients
Reshu et al. Hidden potential of doob grass-an Indian traditional drug
Kakati et al. A Systematic Overview on Some of the Traditionally Used Plants of Assam
Muñoz-Acevedo et al. Some Latin American plants promising for the cosmetic, perfume and flavor industries
Katiyar et al. Evaluation of carrageenan induced antiinflammatory activity of stem extracts of Cuscuta reflexa (Roxb) in rats
Rajan et al. Comparative Review on Pharmacognostical and Pharmacological activities of Ocimum Species
RU2303993C1 (ru) Лечебно-профилактическое средство для молодняка сельскохозяйственных животных и способ профилактики и лечения желудочно-кишечных болезней телят с его применением
RU2637128C1 (ru) Березовый экстракт с отварами лекарственных растений
KR100915893B1 (ko) 숙취예방 및 해소를 위한 생약 추출물 및 이를 이용한 기능성 식품
Yadav et al. Curative aspects of Aegle marmelos (Bael) in drug bioavailability

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12723531

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12723531

Country of ref document: EP

Kind code of ref document: A1