WO2012128655A1

WO2012128655A1 - Device for electroacupuncture diagnostics and medicinal testing

Info

Publication number: WO2012128655A1
Application number: PCT/RU2011/000170
Authority: WO
Inventors: Сергей Александрович ЛУКАНЦОВ; Иван Борисович НЕМКОВСКИЙ; Артем Михайлович ТАРАСОВ
Original assignee: Lukantsov Syergyej Alyeksandrovich; Nyemkovskij Ivan Borisovich; Tarasov Artyem Mikhajlovich
Priority date: 2011-03-18
Filing date: 2011-03-18
Publication date: 2012-09-27

Abstract

The device relates to medical data measurement technology [А61В5/05, А61Н39/00, А61Н39/02], and specifically to devices for examining the dynamics of the electro-conductivity parameters of a person's skin in the region of biologically active points in order to assess the state of the body using electroacupuncture diagnostics and medicinal testing methods, and also with the possibility of a responsive action on the person's skin using safe modulated radiation. The technical result of the claimed solution is the simplification of the process for operating the device and an increase in the range of functional possibilities of the use thereof. The claimed technical result is achieved by the fact that the device for electroacupuncture diagnostics and medicinal testing, which comprises measuring electrodes that are integrated in an interface module with electrodes having an operational booster that is capable of generating a high input resistance at one end and maintaining a reference voltage at the other end, an analog measuring module with an analog-digital converter input, a permanent data storage module, a prescription store module, an inputting/outputting and processing module with a microcontroller, and a communication interface connected via a USB to a computer and power supply, is characterized in that the external prescription stores are connected to the permanent data storage module, said prescription stores including a transistor matrix with an avalanche-type injection of charge and being connected in turn to the inputting/outputting and data processing module and also to the electrode interface module and to a module for forming an external action signal, said module containing a set of solid-state relays, the function of which is to control the external devices.

Description

DEVICE FOR ELECTRIC PUNCH DIAGNOSTICS and

MEDICINAL TESTING

DESCRIPTION

The device relates to medical information measuring equipment

[A61B5 / 05, A61H39 / 00, A61H39 / 02], namely, devices for studying the dynamics of the parameters of the electrical conductivity of the skin of a person in the field of biologically active points for assessing the condition of the body using electro-puncture diagnostics and drug testing, as well as with the possibility of a reverse effect on human skin safe modulated radiation.

Known devices for measuring electrical resistance of the skin of a person in biologically active points, designed for electropuncture diagnostics by the method of R. Voll (Voll R. Arbeitsric tlinien fur die Elektroakupwilctur. -

M.L. Verlag, Hamburg, II Teil, 1963. - 102 s .; Kramer F. Textbook on Electropuncture, τ.Ι -

M .: IMEDIS, 1995. - 189 p.) And its modern modifications, for example, the patent of Russia

N22108085, А61Н 39/00, “Device for electropunctural diagnostics and therapy according to R. Voll’s methods and a method for recording the characteristics of a test object on a carrier for this device” (EE Volkov, I. V. Egorochkin, M. M. Ermolaev, Nakhabtsev V.V., Nikolaev

V.P., Pykhachev G.Yu., Shamarin O.V. 1998) or Russian patent Ν9 2173537, IPC АВВ 5/05

"Device for measuring electric resistance". (A.T. Seleznev,

N.A. Selezneva, Yu.V. Yurov, 2001) containing an indifferent and measuring electrodes connected to a measuring device, a unit for converting electric skin resistance into an output signal recorded in arbitrary units of "conductivity" on a linear measuring scale, memory blocks, containing informational characteristics of the tested agent of biologically active substances in the form of images of these substances on the carrier and a database of the tested states of the human body according to the measured characteristics of the change

resistance of the skin, as well as means of visual display of information (dial indicators and devices or modern means display as a computer display).

In the known devices provides the conversion of electric skin

resistance connected to the circuit between the measuring and indifferent electrodes in the analyzed signal for a given measuring current, and (or) the voltage drop between the electrodes in the output parameter values recorded using the recorder, determined in arbitrary units of conductivity in accordance with the Werner “reference curve” formed when using linear converting elements, as well as the placement of biologically active substances (BAS) between a helium-neon or helium-argon laser and an information carrier onnyh characteristics BAS in the form of a substrate with a film speed so that the laser beam rasfokussirovanny encompassed the whole volume of the BAS, the exposure time corresponds to the time

forming an optical image of a biologically active substance on a carrier and a carrier base of drugs for testing in the form of images of these objects.

The disadvantages of the known devices is the low accuracy, since almost full compliance with the measuring scale of the “Werner curve” can be achieved only by using additional non-linear elements (for example, semiconductor diodes in the circuit of the second recorder) or a non-linear section of the amplitude characteristic of the second amplifier selected during tuning

devices, which is not possible to do automatically in the process of using the device, as well as insufficient accuracy of measuring the BAT electrical conductivity in the values of the conventional units of "conductivity", the increase of which is not possible due to the principle of device construction and low diagnostic information content of the recorded parameters. This significantly narrows the range of application of devices. Closest to the claimed solution is the well-known device according to Russian patent N270775, А61В5 / 05 "Hardware-software complex" Yupran "for electric puncture diagnostics and drug testing" (G. Yusupov 2008), containing one measuring electrode and one contact electrode ,

analog measurement module, memory module, prescription accumulation module, communication interface with a personal computer (PC), where the potential flow between the inputs of the operational amplifier is affected by the current flowing through measuring and contact electrodes, which depends on the electrical conductivity of the skin of the patient being examined and these data are transmitted to a computer. At the same time, in order to improve the accuracy of the measurement results due to the non-critical nature of the spread of the parameters of the operational amplifier, the measurement module basically contains an operational amplifier, included in the repeater circuit, which has a large input and low output impedance. At the output of the amplifier, a voltage of 1.5 to 3.5 V is obtained, depending on the input current, which is in turn the input parameter of an analog-to-digital converter (ADC). The microcontroller processes the obtained data based on 1024 quantization levels for the ADC, and transfers data via the USB port to the computer, where the characteristics of the tested drugs are accumulated in the CMOS cells of the analog keys, and controls the output of the characteristics of the tested drugs to the contact electrode. Using power from the USB port of a personal computer (PC) allows you to exclude the power module from the circuit diagram, and the use of a microcontroller, which includes ADC and USART modules, makes it possible to operate the device together with a pocket PC.

The disadvantages of this device are the complexity of operation and the limited range of applications due to the impossibility of remote expansion of the base of biologically active substances, the inability to interact with external devices to reverse non-invasive effects on the skin of patients, the inability to remotely work on a local or global network, that is, the creation of virtual systems for remote diagnosis of patients . In addition, the separate storage of the information base of the names of “nosodes” - potentized preparations prepared according to certain homeopathic methods, and the nosodes themselves makes it difficult to synchronize several different devices. Using the device with one version of the operating system on computers and another version of the operating system for a Pocket PC forces you to use two different programs with different interfaces, which eliminates the possibility of simple synchronization, and the lack of a common internal bus in the device’s design does not allow it to be scaled.

The technical result of the claimed device is to simplify the process operation of the device and expanding the range of functional capabilities of its application.

The claimed technical result is achieved due to the fact that the device for electropuncture diagnostics and drug testing, containing measuring electrodes combined in an interface module with electrodes with an operational amplifier, configured to form a high input impedance on one side and maintain a reference voltage on the other hand, analog measurement module with one ADC input, module for permanent storage of information, recipe storage module, input-output module and processing and with a microcontroller, a communication interface connected via UBS to a computer and power, characterized in that external recipe storage devices are connected to the module for permanent storage of information, containing a matrix of transistors with avalanche charge injection and, in turn, connected to the input-output module and information processing, as well as to the electrode interface module and to the module for generating an external signal, incorporating a set of solid-state relays, the function of which is to control external devices s.

A common I2C bus can be used as an internal network. In addition, the microcontroller contains built-in USB port and ADC inputs. In addition, the cells of transistors with avalanche charge injection are formed into a matrix with a parallel-serial structure. In addition, the input / output and information processing module is connected to remote computer devices via wired or wireless communication systems. Also used

microcontroller type PIC18XXX.

The essence of the solution is a device containing measuring electrodes combined in an interface module with electrodes with an operational amplifier, connected in a special way to form a high input impedance on one side, and on the other hand to maintain a reference voltage, an analog measurement module with one ADC input, a permanent storage module information, recipe storage module, input-output and processing module with a microcontroller, communication interface connected via UBS to a computer and power.

Distinctive features of the proposed solution is that the device uses a modern microcontroller, for example, of the PIC18XXX type, in which the USB port and four ADC inputs are built-in, the transistors with avalanche charge injection formed in the matrix with parallel - a sequential structure, the modules are interconnected via a common internal I2C bus for interaction with input and output devices, and

automated coordination of their work, and solid-state relays were used as control elements for external devices, while external prescription drives are connected to the permanent information storage module, and the input-output and information processing module is connected to remote computer devices via the intranet, the Internet, and other communication systems.

Figure 1 shows the inventive device in which the measuring electrodes (10) are connected to the electrode interface module (2), and the module for permanent storage of information (3) is connected via an interface to the external information storage module (7) and is connected to a common network with prescription storage module (4), which contains a matrix of transistors with avalanche charge injection (14) and, in turn, is connected to the input-output and information processing module (1), as well as to the electrode interface module (2) and to the module for generating an external signal (5), incorporating a set of solid state relays (13). As an internal network, the common I2C bus - (12) was used. Interface module with

electrodes (2) contains an operational amplifier connected in a special way to form a high input impedance on one side and to maintain a reference voltage on the other hand, and the input-output and processing module (1) includes a modern PIC18XXX microcontroller (9), which has the composition of the ADC with four inputs and a built-in USB interface, while external devices (8) for safe exposure to the patient’s skin are connected to the module the formation of an external influence signal (5), and the input-output and information processing module is connected to a line of external devices for analyzing and displaying information (6), which can have remote communication with remote

computer devices via the intranet, the Internet, or other communication systems (11). The device in figure 1 works as follows: when

electropuncture diagnostics and drug testing of a patient, measuring electrodes (10) are supplied to his hands, to which reference voltage is supplied from the electrode interface module (2) together with wave

characteristics of the studied nosode formed by the prescription storage module (4).

Nosodes are preparations prepared according to certain

homeopathic methods of their production from pathologically altered organs (or parts of organs) of humans and animals, as well as from dead cultures

microorganisms, decomposition products of organs and fluids containing

causative agents of the disease or its products.

Isopathy is understood to mean the use of an autonomozoic (autonomozod) drug prepared from non-pathogenic material of the disease itself or the patient himself, for example, from the blood of the patient himself. Currently, its forms such as auto vaccines (auto vaccines) and the patient’s own blood are used.

Nosode, in our case, is an energy wave packet,

sufficiently reflecting the structure of the real object - potentiated preparations prepared according to certain homeopathic methods or the properties of bacteria, fungi, various infections, poisons, toxins, etc., affecting the human body.

The microcontroller (9) in the input-output and processing module (1) through the first ADC input digitizes the signals from the electrodes (10) and receives information for processing from the electrode interface module (2). After digitization, the processed signal level information in digital form is transmitted via the bus and USB-πορτ to external information analysis and display devices (6) for further processing and visualization of the signal, for example, on a linear scale conventionally displayed on the display. In this case, the current flowing through the electrodes (10) with the existing reference b voltage, displays a negative reaction of the patient’s skin in the case when the value of the measured current strength according to the readings of external analysis and information display devices (6) is in the range from 30-45 μA, and as a positive reaction of the patient’s skin when the strength of the pressure is in the range of 55 -65 μA.

The microcontroller (9) in the input-output and processing module (1) through the second input of the ADC also digitizes the impact and response signals transmitted from the external signal generation module (5), which works in the exchange of information with external devices (8) of safe exposure on the skin of the patient. After the transmission of these signals from module (1) and processing on external devices for analyzing and displaying information (6), the input-output and processing module (1) issues a feedback signal to module (5) that controls the operation of devices (8) by switching external currents to 500 tA.

The microcontroller (9) using the third input of the ADC and the common I2C bus (12) connected to the module for the permanent storage of information (3) and, in turn, connected to the external information storage module (7), performs addressing of the nosode cells and reading of the nosode parameters reflecting the properties of bacteria, fungi, various infections, poisons, toxins, etc., affecting the human body, from the base of the external information storage module (7), which are pre-recorded there by determining their parameters.

The microcontroller (9) using the fourth input of the ADC also through the common I2C bus (12) connected to the recipe storage module (4), uses a transistor array with avalanche charge injection (14), thereby controlling the formation of the recipe from a set of nosodes, representing the properties of potentized drugs prepared according to certain homeopathic methods.

During operation of the claimed device in FIG. 1, also interacts with a line of various external devices for the analysis and display of information (6) on a local and / or global network and transmission-reception

information on the intranet, the Internet, and other communication systems (11).

As an example, research data on the development of the principle of operation of our device during its design and testing are presented. Development the electronic analog of the nosodes was carried out in the framework of the classical Voll scheme (Figure 2), characterized by the presence of a key (18), the absence of a measuring device, while the object under study was replaced by an element (19) in which the electronic analogue is stored.

The description of physical processes was carried out taking into account work in the field of studies of excited states in solids.

Known information allows us to approach the description of physical processes only in a phenomenological aspect. In this case, the possibility was considered

the use of excited states to identify the structure of the object (15) (Figure 2), transmit energy information through the conductors (16) and write it to the element (19).

Figure 2 shows the scheme for creating an electronic analogue, where 15 is a certified nosode, 16 is a conductor, 17 is a current source, 18 is a key, 19 is an electronic analogue recording element.

It is known that the structural features of an object manifest themselves in the form of excitations, like quasiparticles. In particular, the bound state of an electron hole in molecular crystals is called excitons of small radius, and in semiconductors they are called excitons of large radius. Such a bond can be considered as a hydrogen-like state or as a quasi-hydrogen in the medium under consideration. To determine the energy characteristics, as well as for hydrogen, the same tools of quantum mechanics, primarily the Schrödinger equation, can be used. In the embodiment for a hydrogen-like at an energy E <0, i.e. for a bound state, the equation has the form:

where: R is the inat of the center of mass of the electron-hole pair,

ε is the dielectric constant;

n, I, m - the main, orbital and magnetic quantum numbers;

is a quasimomentum that determines the translational motion of an electron – hole pair as a whole. The limiting energies of this state are determined for semiconductors and electricians with a band gap and are estimated by the dependence

Where:

k, n, m _e , m _h - wave vector, quantum number, mass of electron and hole.

The energy of excitons is estimated from the principal quantum number n as

where: E _g , R _ex , k, M, is the band gap, the effective readberg or binding energy of the exciton, the wave vector of the exciton, the sum of the masses of the electron and the hole, Planck's constant divided by 2π.

Excitons are excited by various effects, for example, by light, i.e. photons with a certain energy. Further, the excitons make their own contribution to the polarizability of the crystal, which is macroscopically described by the complex dielectric function e (c £>, k), which depends on the frequency ω and the wave vector k. The dispersion relation of such a mixed state of an elementary

excitation and light has the form:

where c is the speed of light in vacuum.

The quanta of eigenstates obeying this equation are called polaritons. In modern literature, polaritons are understood to mean any mixed state formed by the elementary excitation of a crystal and an electromagnetic field. These are exciton, phonon, plasmon polaritons, depending on the correspondence of the dielectric constant ε to excitons, phonons, or plasmons. The above relations relate to bulk polaritons, however, all of them have surface analogs — surface polaritons (PP). These modes are transverse magnetic waves with an electric field periodic along the crystal surface. The energy dependences on the wave vector for phonon polaritons, as an example, are shown in FIG. 3 (a).

In FIG. Figure 3 shows a schematic representation of the dependence of energy on the wave vector: a - for photonic, b - for exciton polaritons.

Numbers 1, 2 denote the lower and upper branches of bulk polaritons

respectively; S- dispersion curves of surface polaritons: the refractive index of the environment is taken n ₀ = 1.

A typical dispersion curve of the surface photon polariton (FPP) is located in the energy gap between the boundaries of the existence of a longitudinal longitudinal co _L (branch 2) and transverse ω _τ (branch 1) frequencies. As noted in known works, in this case the condition is satisfied when the real part of the dielectric constant is negative and in absolute value exceeds its value in the neighboring medium. It should also be noted the small dependence of the FPP on the external radiation exposure of light, since their phase velocity ω / k is always less than the phase velocity of light in the environment with an index of n ₀ . FPPs can neither turn into photons moving away from the surface, nor can they be excited under simple illumination.

The description of exciton polaritons, unlike the FPP, requires taking into account the rest energy of the exciton (k = 0) and the energy of motion of its center of mass through a change in the type of dielectric constant s (co, k) into which β1 is introduced. ² , taking into account spatial dispersion. The type of dispersion curves and the nature of the change of branches 1, 2 are shown in FIG. 2 (b). The difference is manifested in the dependence of the dispersion curve S and the transverse mode (branch 1) on k.

A similar analysis can be carried out for all types of excitations, showing that the spectra of elementary excitations of the object quite fully represent the energy state of the object and can serve as peculiar probes of this state, since they are all presented in the form of various surface polaritons.

The transmission of energy information of an object-semiconductor is not sufficiently lit.

Presumably, such a transfer is possible, since here the overlapping of the wave functions of the object-conductor is observed, which significantly changes

electric field of the surface of the conductor. Accordingly, the conditions for the appearance and propagation of surface plasmons change. In the polariton spectrum of the conductor, an additional PP wave packet should be expected, which determines the energy-information characteristics of the object.

An important issue is the transmission of energy information through the conductor. According to known data, the distribution of PP over distances of 50-100 microns is shown. However, this applies to the light excitation of PP by the method of disturbed total

internal reflection (ATR).

The appearance of plasma PP under the action of rectangular pulses can be considered in a two-coordinate system. One of the systems is attached to the object, the second to mobile carriers. PPs are considered at the interface between the media (binding to the object) and on mobile carriers. Since electrons have a finite velocity v> 0, the PP motion in this medium obeys the Doppler effect relative to the object; accordingly, the wavelengths of the PP packet increase in the direction of electron motion, and the PP lifetime in this direction also increases. From this point of view, one can explain the transmission of PP over long distances in some experiments and the insufficiently illuminated effect of self-focusing or transparency in the literature.

As an element of energy information storage, we used a set of memory cells created using avalanche charge injection technology. The system contains a η-type drain-source with a silicon oxide insulator and two isolated shutters located one above the other. The gate directly in contact with the channel dielectric is fully electrically isolated. The recording mechanism is based on the fact that during the passage of a plasmon wave at the semiconductor-insulator, insulator-conductor, and conductor-insulator boundaries at small layer thicknesses, the characteristics of these layers change, they turn out to be translucent. In dielectric layers, surface PP can be converted into bulk and the formation of exciton structures of small radius, which uniquely determine the energy-information characteristics of the object.

Consideration of possible physical processes at various points in the chain (Figure 1) made it possible to create a cell for temporary storage of energy-information

4, where the cell of temporary storage of the energy-informational characteristics of the nosode is shown.

The cell consists of an insulated gate transistor and three field keys. Writing a nosode to a cell:

The initial state with private keys 20, 21, 22. Opening the key 22 closes the gate of the transistor to ground. Opening the key 20 leads to the formation of

a picosecond pulse (due to the small capacitance) of the source-gate and the formation of a plasmon wave in this circuit, which forms an exciton structure between the gate and the channel.

Nosode Playback:

Closing the keys 20, 22 and opening the key 21 connects the channel of the transistor 23 to the measurement circuit 24. Further measurements according to our methodology give

similar to the reference nosode response.

The advantages of the claimed solution are to simplify the operation of the device and expand the range of its application due to the fact that the I2C common bus is used as the model’s internal network, which greatly simplifies the circuitry, and also due to the fact that the input-output and processing module incorporates the modern PIC18XXX microcontroller, as part of an ADC with four inputs and a built-in USB interface, which, in turn, makes it possible to simplify and miniaturize the device as a whole. The use of a common bus 12C in conjunction with current software allows us to consider a wide range of computing devices operating under

operating systems Windows, Mac Os, Linux, iPad, iPhone, including touch-technology, using a single graphical interface that does not require additional coordination. The design of the permanent storage module allows you to store not only nosodes, but also information about them, which significantly increases the accuracy and the efficiency of the device. The ability to use external drives to send updates to the nosodes allows you to quickly update the information base of the nosodes of the model, and with each update, expand the range of application of the device. The interface module with external devices allows you to interact with external diagnostic devices and systems, which significantly expands the scope of the model. The ability to work remotely and manage through a local and global network allows for distance learning, consultations, etc. for operational interaction and teamwork. Thus, the device can be used in stationary, outpatient and field conditions for the diagnosis and selection of treatment.

Claims

FORMULA

1. Device for electropuncture diagnostics and medication

test, containing measuring electrodes, combined in the interface module with electrodes with an operational amplifier, configured to form a high input on one side

resistance, and on the other hand, maintaining the reference voltage, an analog measurement module with one ADC input, a module for permanent storage of information, a recipe storage module, an input-output and processing module with a microcontroller, a communication interface connected via UBS to a computer and power supply, characterized in that external recipe storage devices are connected to the module of permanent information storage, containing a matrix of transistors with avalanche charge injection and, in turn, connected to the input-output and processing module information, as well as to the electrode interface module and to the module for generating an external signal, incorporating a set of solid-state relays, the function of which is to control external devices.

2. The device according to claim 1, characterized in that as an internal network

Common I2C bus used.

3. The device according to p. 2 characterized in that the microcontroller contains

built-in USB port and ADC inputs.

4. The device according to claim 3, characterized in that a PIC18XXX type microcontroller is used.

5. The device according to p. 1 characterized in that the cells of the transistors with an avalanche

charge injection formed into a matrix with a parallel-serial structure.

6. The device according to p. 1 or p. 2, or p. 3, or p. 4, or p. 5 characterized in that

an input / output and information processing module is connected to remote computer devices via wired or wireless communication systems.