WO2012124890A3 - meso-2,3-부탄다이올의 제조방법 - Google Patents
meso-2,3-부탄다이올의 제조방법 Download PDFInfo
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- WO2012124890A3 WO2012124890A3 PCT/KR2012/000436 KR2012000436W WO2012124890A3 WO 2012124890 A3 WO2012124890 A3 WO 2012124890A3 KR 2012000436 W KR2012000436 W KR 2012000436W WO 2012124890 A3 WO2012124890 A3 WO 2012124890A3
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Abstract
본 발명은 meso-2,3-부탄다이올 제조방법에 관한 것이다. 보다 상세하게는, 다음의 뉴클레오티드 서열로 구성된 군으로부터 선택되는 최소 1종의 뉴클레오티드 서열을 포함하는 발현벡터로 형질전환된(cotransformed) meso-2,3-부탄다이올 과발현용 대장균를 제공한다: (a) 서열목록 제5서열에 기재된 아미노산 서열을 가지는 아세토인 환원효소(acetoin reductase)을 코딩하는 뉴클레오티드; (b) 아세토락테이트 디카복실레이즈(acetolactate decarboxylase)를 코딩하는 뉴클레오티드; 및 (c) 알코올 디하이드로지네이즈(alcohol dehydrogenase)를 코딩하는 뉴클레오티드. 본 발명의 형질전환 대장균은 야생종에서는 생산하지 못하는 2,3-부탄다이올을 생산할 수 있다. 따라서 당으로부터 meso-2,3-부탄다이올 생합성 경로 발현과 다른 종의 유전자 삽입에 의한 대사 흐름 변경을 통해 대량의 meso-2,3-부탄다이올 생합성이 가능하다.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020110022359A KR101334971B1 (ko) | 2011-03-14 | 2011-03-14 | 비병원성 2,3-부탄다이올 생산을 위한 이종 대장균 및 제조방법 |
KR10-2011-0022359 | 2011-03-14 |
Publications (2)
Publication Number | Publication Date |
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WO2012124890A2 WO2012124890A2 (ko) | 2012-09-20 |
WO2012124890A3 true WO2012124890A3 (ko) | 2012-12-27 |
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PCT/KR2012/000436 WO2012124890A2 (ko) | 2011-03-14 | 2012-01-18 | meso-2,3-부탄다이올의 제조방법 |
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KR (1) | KR101334971B1 (ko) |
WO (1) | WO2012124890A2 (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013076144A2 (en) * | 2011-11-21 | 2013-05-30 | Metabolic Explorer | Microorganism strains for the production of 2,3-butanediol |
KR101534221B1 (ko) * | 2013-06-04 | 2015-07-09 | 서강대학교산학협력단 | (a) wabG 유전자가 불활성화 되어 있고 (b) budR 유전자가 과발현된 2,3-부탄다이올 생산용 재조합 균주 |
KR101590993B1 (ko) | 2013-12-12 | 2016-02-02 | 서울대학교산학협력단 | 재조합 효모를 이용한 2,3-부탄다이올의 생산방법 |
WO2016064180A1 (ko) * | 2014-10-21 | 2016-04-28 | 주식회사 아모레퍼시픽 | 메조-2,3-부탄디올을 함유하는 조성물 |
US11091741B2 (en) | 2015-10-27 | 2021-08-17 | Korea Research Institute Of Bioscience And Biotechnology | Method for producing medium chain diol |
KR102028161B1 (ko) * | 2017-01-10 | 2019-10-02 | 경희대학교 산학협력단 | 형질전환 미생물을 이용한 2,3-부탄디올 생산방법 |
US10858661B2 (en) | 2017-01-10 | 2020-12-08 | University-Industry Cooperation Group Of Kyung Hee University | Use of Methylomonas sp. DH-1 strain and its transformants |
CN108570440A (zh) * | 2018-03-23 | 2018-09-25 | 山东大学深圳研究院 | 一株重组大肠杆菌及其在生产光学纯meso-2,3-丁二醇中的应用 |
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2011
- 2011-03-14 KR KR1020110022359A patent/KR101334971B1/ko active IP Right Grant
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- 2012-01-18 WO PCT/KR2012/000436 patent/WO2012124890A2/ko active Application Filing
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Publication number | Publication date |
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KR20120107021A (ko) | 2012-09-28 |
WO2012124890A2 (ko) | 2012-09-20 |
KR101334971B1 (ko) | 2013-12-05 |
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