WO2012124214A1

WO2012124214A1 - Intraoral retaining agent for animal use, intraoral environment-improving agent for animal use, and intraoral environment-improving method for animal use

Info

Publication number: WO2012124214A1
Application number: PCT/JP2011/077345
Authority: WO
Inventors: 佳彦中野; 智佳水主
Original assignee: アース・バイオケミカル株式会社
Priority date: 2011-03-11
Filing date: 2011-11-28
Publication date: 2012-09-20
Also published as: JPWO2012124214A1; TW201302240A; JP5090578B2

Abstract

Provided is an intraoral retaining agent for animal use having an excellent effect in terms of intraoral retention of an active ingredient. The intraoral retaining agent for animal use is characterized in that an intraoral retaining agent for animal use that is used together with an active ingredient for improving the intraoral environment of an animal and retains the active ingredient inside the oral cavity comprises beeswax and a vegetable oil and has a beeswax content of 0.1 to 29.9 wt%.

Description

Oral retention agent for animals, oral cavity environment improving agent for animals, and oral cavity environment improving method for animals

The present invention relates to an oral cavity retention agent for animals administered into the oral cavity of an animal, an oral cavity environment improving agent for animals comprising the oral cavity retention agent for animals and an active ingredient for improving the oral environment of the animal, and The present invention relates to a method for improving the oral environment of animals using the animal oral retention agent.

Conventionally, attention has been focused on improving oral diseases of animals, particularly pets such as dogs and cats. Examples of oral diseases in animals include periodontitis, gingivitis, alveolar pyorrhea, and periodontitis. If symptoms worsen, teeth may be removed. As a cause of these developments, it is considered that food waste accumulates in the oral cavity, so that calcium in saliva or the like is deposited on the surface of the teeth and calculus is formed. When an oral disease develops, the bad breath becomes stronger depending on the symptom, which may interfere with the relationship with the owner.

As a treatment method, when the adhesion of calculus is increased and the symptoms in the oral cavity worsen, treatment such as removal of calculus under general anesthesia is performed, but the burden on the body is great for dogs. As a treatment / prevention method other than the above, the owner rubs the dog's teeth and tartar with a toothbrush, gauze, etc. using a dentifrice on a daily basis. There are problems such as being unfamiliar and difficult to perform sufficient treatment. In order to solve such problems, various shapes of brushes, ropes, uneven toys, hard snacks, dry foods with a cleaning effect in the oral cavity, etc. that can clean the teeth when dogs bite themselves are commercially available. ing. If these are used, the dog will be treated by himself and the burden on the owner will be reduced. However, brushes, ropes, and uneven toys will not be fully effective if the dog gets bored. In addition, hard foods and dry foods that have a cleaning effect in the oral cavity have problems such as poor eating ability of dogs or inadequate effects when swallowed easily.

On the other hand, ingredients that improve the oral environment are blended into pet food to treat and prevent diseases. For example, Patent Document 1 discloses blending an extract extracted from noni fruits as a component for improving the oral environment in jelly, agar, candy, and tablet-shaped pet food. Moreover, in patent document 2, the method of apply | coating sodium hexametaphosphate to the surface of a dry food and feeding a pet is disclosed.

JP 2007-89414 A JP 7-507927 A

However, in the above-described method, a component that improves the oral environment cannot be retained in the oral cavity due to the cleaning action of the animal's saliva, and the effective concentration cannot be maintained in the oral cavity. Not. If sufficient retention time of the active ingredient in the oral cavity can be ensured, the effect and efficacy of the active ingredient can be further increased, and the use amount of the active ingredient can be expected to be reduced.

Accordingly, as a result of studying a method for maintaining the effective concentration of the active ingredient longer in the oral cavity, the present inventors have formulated vegetable oil among the raw materials satisfying the safety required for pet food and further contain beeswax. As a result, it was found that the retention effect of the active ingredient in the oral cavity was particularly excellent, and the present invention was completed. That is, the present invention relates to an animal oral retention agent excellent in the oral retention effect of an active ingredient, an animal oral environment improving agent containing the animal oral retention agent, and an animal using the animal oral retention agent An object of the present invention is to provide a method for improving the intraoral environment.

The present invention is an animal oral retention agent that is used together with an active ingredient for improving the oral environment of an animal and retains the active ingredient in the oral cavity, containing beeswax and vegetable oil, and the content of beeswax The present invention relates to a vaginal retention agent for animals, characterized in that

The vegetable oil content is preferably 70.1 to 99.9% by weight.

The present invention also relates to an animal oral environment improving agent comprising the animal oral retention agent and an active ingredient for improving the animal oral environment.

Furthermore, the present invention relates to a method for improving the oral environment of animals, characterized by using the above-mentioned animal oral retention agent together with an active ingredient for improving the oral environment of animals.

According to the present invention, since the active ingredient for improving the oral environment of the animal can be retained in the oral cavity for a predetermined time or more, the efficacy of the active ingredient can be sufficiently exhibited in the oral cavity. In addition, veterinary retention agents for animals are easy to manufacture, easy to handle and excellent in practicality.

It is the graph which showed the relationship between the beeswax density | concentration in Test 2, and the intraoral residence time of a pigment | dye. It is the graph which showed the evaluation of the bad breath of the dog in Test 3.

In the present invention, animals include pets such as dogs and cats, and livestock animals such as cows and pigs, not humans. Among them, the animal oral retention agent of the present invention is preferably used for pet animals that are strongly required to improve the oral environment such as the improvement of bad breath in relation to the owner, and is most suitable for dogs that are easy to administer to the oral cavity. Preferably used.

In addition, being used together with the active ingredient in the present invention means a state in which the active ingredient coexists in the oral cavity, and the synchronism of the administration timing of the active ingredient and the animal oral retention agent is not required. Therefore, the veterinary retention agent for animals can be used before and after the administration of the active ingredient within a time in which it can coexist with the active ingredient in the mouth. Especially, it is preferable to use an active ingredient and a veterinary retention agent for animals simultaneously from the reason that the retention of an active ingredient is improved and it does not take time and effort.

The animal oral retention agent of the present invention contains beeswax. The beeswax is not particularly limited, and the melting point, iodine value, saponification value, etc. are not particularly limited, but the melting point is low because it is easy to formulate, is not easily affected by environmental temperature, and has excellent storage stability. 60.0 to 67.0 ° C., an iodine value of 5.0 to 15.0, and a saponification value of 77.0 to 103.0 are preferable.

The content of beeswax is 0.1 to 29.9% by weight, preferably 1.0 to 29.0% by weight, more preferably 5.0 to 27.0% in the oral cavity retention agent for animals. % By weight, most preferably 17.0-23.0% by weight. If the amount is less than 0.1% by weight, the effect of retention of the active ingredient in the oral cavity tends not to be obtained. If the amount exceeds 29.9% by weight, the animal oral retention agent does not reach the teeth, gums, and palate, and There is a tendency that the internal retention effect cannot be obtained.

The veterinary retention agent for animals of the present invention can contain liquid or solid oils and fats such as animal oils and / or vegetable oils, but has a lower melting point than animal oils, making it easy to adjust the viscosity during formulation. Yes, it contains a lot of unsaturated fatty acids and is useful for use in living organisms, and further contains vegetable oil as an essential component.

The vegetable oil is not particularly limited, and examples thereof include soybean oil, palm oil, coconut oil, sunflower oil, peanut oil, corn oil, rapeseed oil, linseed oil, sesame oil, and canola oil. Among these, sunflower oil is preferable because it is excellent in the storage stability of the preparation and the palatability of animals.

The content of the vegetable oil is not particularly limited, but is 70.1 to 99.9% by weight, preferably 71.0 to 99.0% by weight, more preferably 73.0% in the vaginal retention agent for animals. It is ˜95.0% by weight, and most preferably 77.0 to 83.0% by weight. If the vegetable oil content is less than 70.1% by weight, the diffusibility in the oral cavity tends to be low. If the vegetable oil content exceeds 99.9% by weight, the beeswax content decreases and the oral retention effect is obtained. There is no tendency.

The animal oral retention agent may contain various waxes in addition to beeswax. The wax other than beeswax is not particularly limited, and examples thereof include urushi wax, carnauba wax, candelilla wax, rice bran wax, sugar cane wax, shellac wax, paraffin wax, microcrystalline wax, montan wax, and lanolin. The content of these waxes is not particularly limited, but is preferably 10% by weight or less.

Moreover, the animal oral retention agent may contain animal oil in addition to vegetable oil. Although it does not specifically limit as animal oil, Various tallow and fish oil are mention | raise | lifted. The content of these animal oils is not particularly limited, but is preferably 10% by weight or less.

Further, the veterinary retention agent for animals is an optional component within the range not impairing the effects of the present invention, and further includes sweeteners, fragrances, solubilizers, pH regulators, moisturizers, preservatives, thickeners, surfactants. You may contain an agent, a solvent, etc.

The veterinary retention agent for animals containing the above-described components can retain the active ingredient in the oral cavity of the animal, and is preferably active ingredient for 3 minutes or more, more preferably 10 minutes or more, most preferably 15 minutes or more. Can be retained in the oral cavity.

The amount of animal oral retention agent used to improve the oral environment of animals is determined by various factors such as the effective concentration of the active ingredient and the age, sex, and condition of the target animal. There is no particular limitation.

The dosage form of the veterinary retention agent for animals of the present invention is not particularly limited, but is liquid, emulsion, cream, lotion, paste, mousse, gel, ointment because it is easily applied to the oral cavity. Chewable and soft capsules are preferred.

In the present invention, the active ingredient is an active ingredient for improving the oral environment of animals, and is used for the treatment and prevention of oral diseases such as periodontitis, gingivitis, alveolar abscess, and periodontitis in animals. It contains medicinal ingredients and contains active ingredients for improving the above diseases and bad breath. Examples of such active ingredients include various lactic acid bacteria such as Lactobacillus and Bacillus, live bacteria such as butyric acid bacteria, Bacillus subtilis, and Bifidobacterium, known stain prevention / removal agents, calculus prevention / removal agents, and dental caries prevention・ Restoration agent, hypersensitivity prevention / suppression agent, bad breath prevention / removal / concealment agent, gingivitis / periodontitis prevention / amelioration agent, bactericidal agent, antibacterial agent, antibiotic, enzyme, antibody, vitamin, mineral Can be used according to the purpose. Among these, the animal oral retention agent of the present invention preferably uses a live bacterial agent as an active ingredient because it increases in bacteria in the oral cavity with the extension of the residence time and increases its effectiveness. For the purpose of preventing and improving bad breath in pets, it is particularly preferable to use lactic acid bacteria as active ingredients.

The form of the active ingredient is not particularly limited, but since the vaginal retention agent for animals essentially contains an oily component, it is preferably in the form of a powder, granule, oil, or paste that is easy to mix. In the case of using a compound that is difficult to disperse in the veterinary retention agent for animals, it is preferable to perform mixing such as powdering in advance.

The animal oral environment improving agent of the present invention contains an animal oral retention agent and an active ingredient for improving the oral environment of the animal. As the animal oral retention agent and the active ingredient, the above-described ingredients can be used. The dosage form may be the same as the animal oral retention agent.

The method for improving the oral cavity environment for animals of the present invention is characterized by using the above-mentioned animal oral retention agent together with an active ingredient for improving the oral cavity environment of animals as described above. More specifically, the step of mixing the animal oral retention agent and the active ingredient, the step of administering the animal oral environment improving agent comprising the obtained mixture into the oral cavity of the animal, and the active ingredient in the animal And the step of retaining in the oral cavity. In addition, the number of times the veterinary retention agent for animals and / or the oral environment improving agent for animals is administered to the oral cavity is not particularly limited, but is preferably 1 to 2 times a day, preferably once a day. Is more preferable.

Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited to these examples. In the examples, “parts” and “%” are based on weight unless otherwise specified.

The raw materials used in the examples are as follows.
Beeswax: Purified beeswax (manufactured by Toa Kasei Co., Ltd., melting point 64 ° C., iodine value 8.5, saponification value 93)
Sunflower oil: Edible sunflower oil (made by Showa Sangyo Co., Ltd.)
Beef extract: B-Fex AW-8L (Fuji Food Industry Co., Ltd.)
Beer yeast: Mist P1G (Asahi Food and Healthcare Co., Ltd.)
Gelling agent: FJ-3085 (Nitta Gelatin Co., Ltd.)
Lactic acid bacteria: Lacris-S powder (Mitsubishi Chemical Foods, Inc., powdered lactic acid bacteria)

<Test 1: Examination of residence time>
Example 1
Ten parts of beeswax and 90 parts of sunflower oil were mixed to obtain a paste-like animal oral retention agent. What added 0.1 part of pigment | dye with respect to 100 parts of this intraoral retention agent for animals was further mixed, and about 0.1 g of the obtained sample was administered into the oral cavity of a dog. After the administration was completed, the pigment staying on the surface of the dog's oral cavity (especially teeth, gums, palate) was visually observed, and the time until the pigment was not observed was measured. Observations were made at intervals of several seconds immediately after the start until 1 minute, and observations were made at intervals of 1 minute after 1 minute. The test was performed on two dogs, and the average value was used.

Comparative Example 1
0.1 parts of pigment was added to and mixed with 100 parts of water, and about 0.1 g of the obtained sample was administered into the oral cavity of a dog. After completion of the administration, the dye staying on the surface in the oral cavity was visually observed by the same method as in Example 1, and the time until no dye was observed was measured.

Comparative Example 2
To 100 parts of sunflower oil, 0.1 part of a pigment was added and mixed, and about 0.1 g of the obtained sample was administered into the oral cavity of a dog. After completion of the administration, the dye staying on the surface in the oral cavity was visually observed by the same method as in Example 1, and the time until no dye was observed was measured.

Comparative Example 3
3 parts of beef extract, 1 part of brewer's yeast, 1 part of a gelling agent were added to and mixed with 95 parts of water, and 0.1 part of pigment was added and mixed to obtain a jelly-like sample. About 0.5 g of this sample was administered into the dog's mouth. After completion of the administration, the dye staying on the surface in the oral cavity was visually observed by the same method as in Example 1, and the time until no dye was observed was measured.

Comparative Example 4
The pigment dissolved in alcohol was sprayed on a commercially available dry food for dogs by spraying so that the pigment was 0.1 part with respect to 100 parts of the dry food. After the alcohol was removed by drying, about 5 g of the pigmented dry food was fed to the dog. After the end of eating, the dye staying on the oral cavity surface was visually observed by the same method as in Example 1, and the time until the dye was not observed was measured.

The results of Example 1 and Comparative Examples 1 to 4 are shown in Table 1.

As shown in Table 1, in Example 1 using beeswax and sunflower oil, the retention effect of the pigment was observed in the oral cavity, whereas in Comparative Examples 1, 3 and 4, it was observed in the oral cavity even immediately after administration. No dye retention was observed. Further, in Comparative Example 2 using only sunflower oil, although the pigment retention effect was slightly observed, the retention time was shorter than that in Example 1.

<Test 2: Examination of residence time by beeswax content>
Examples 2 to 6 and Comparative Examples 5 to 6
Beeswax and sunflower oil were mixed according to the formulation shown in Table 2 to obtain an oral cavity retention agent for animals. To 100 parts of the animal oral retention agent, 0.1 part of pigment was added and mixed, and about 0.1 g of the obtained sample was applied to the canine of the dog and the periphery of the canine. After completion of the application, the pigment staying on the surface of the dog's teeth was visually observed, and the time until the pigment was not observed was measured. Observations were made at intervals of several seconds from just after the start until 1 minute, and after 1 minute as a rule, observations were made at intervals of 1 minute. The test was performed on two dogs, and the average value was used. The results are shown in FIG.

In Examples 2 to 6, there was a tendency that the retention time of the dye became longer as the beeswax content increased. However, in Comparative Example 6 in which the content of beeswax exceeded 30% by weight, the retention time of the dye decreased rapidly. Further, in Comparative Example 5 containing no beeswax, it was observed that the pigment flowed down from the tooth surface immediately after application, and a sufficient retention effect was not obtained.

<Test 3: Evaluation of bad breath in dogs>
Examples 7 to 8 and Comparative Examples 7 to 8
The raw materials having the composition shown in Table 3 were mixed to obtain an animal oral environment improving agent sample containing an animal oral retention agent and an active ingredient. After evaluating the strength of the bad breath of the dog by sensory evaluation, the dogs were randomly divided into each test group (4 each) so that the test results before the start of administration were the same among the test groups. The sample was administered once a day by 0.1 g into the oral cavity of the dog of each test group. The test was conducted for 5 days, and the bad breath was evaluated once a day before sample administration.

(Method of evaluating bad breath)
Perform sensory evaluation with 4 panelists, score the numbers corresponding to the following 6 levels of evaluation (maximum 5 points), find the average score of all panelists for all dogs in each group, and evaluate the bad breath Using. The results are shown in Table 3 and FIG.
5: A strong odor that can be seen without bringing the nose close to the dog's mouth. It is unbearable to sniff with your nose close.
4: Strong smell. I can get close to my nose, but I can't stand breathing deeply.
3: Smell clearly understood.
2: A weak smell.
1: Slight smell, but if you sniff carefully, you will feel bad breath.
0: I do not feel bad breath.

As shown in Table 3, in Example 7, Example 8, and Comparative Example 8, it was confirmed that the bad breath decreased with the administration of the sample. In Comparative Example 7 containing no lactic acid bacteria as an active ingredient, the evaluation of bad breath varied somewhat depending on the day, but the results were generally constant. In addition, it was confirmed that the bad breath was reduced with administration in Comparative Example 8 which did not contain beeswax, but the degree of reduction was moderate compared with Examples 7 and 8 containing beeswax. Furthermore, when Example 7 and Example 8 were compared, it was shown that Example 8 with a higher beeswax content reduced bad breath and maintained its effect in a shorter time. From the above, it can be seen that by using an animal oral retention agent in which beeswax is blended with vegetable oil, the active ingredient is retained in the oral cavity, and the efficacy of the active ingredient is sufficiently exhibited in the oral cavity.

Claims

A veterinary retention agent for animals that is used together with an active ingredient for improving the oral environment of animals and retains the active ingredient in the oral cavity, which contains beeswax and vegetable oil, with a beeswax content of 0.1 An oral cavity retention agent for animals, characterized in that it is ˜29.9% by weight.
The veterinary retention agent for animals according to claim 1, wherein the vegetable oil content is 70.1 to 99.9% by weight.
A veterinary environment improving agent for animals comprising the vaginal retention agent for animals according to claim 1 or 2, and an active ingredient for improving the oral environment of the animal.
A method for improving an oral cavity environment for animals, comprising using the animal oral retention agent according to claim 1 or 2 together with an active ingredient for improving the oral cavity environment of an animal.