WO2012121862A3 - Composés dérivés de l'acide valproïque - Google Patents

Composés dérivés de l'acide valproïque Download PDF

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Publication number
WO2012121862A3
WO2012121862A3 PCT/US2012/025627 US2012025627W WO2012121862A3 WO 2012121862 A3 WO2012121862 A3 WO 2012121862A3 US 2012025627 W US2012025627 W US 2012025627W WO 2012121862 A3 WO2012121862 A3 WO 2012121862A3
Authority
WO
WIPO (PCT)
Prior art keywords
valproic acid
acid derivative
derivative compounds
disorders
methods
Prior art date
Application number
PCT/US2012/025627
Other languages
English (en)
Other versions
WO2012121862A2 (fr
Inventor
A. M. Mahbub HASSAN
Guenther Hochhaus
Paul R. Carney
Original Assignee
University Of Florida Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Florida Research Foundation filed Critical University Of Florida Research Foundation
Publication of WO2012121862A2 publication Critical patent/WO2012121862A2/fr
Publication of WO2012121862A3 publication Critical patent/WO2012121862A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés acide valproïque:dextran et des procédés pour les utiliser. L'invention concerne en outre des compositions pharmaceutiques et des procédés de traitement de diverses maladies et troubles, notamment un trauma cérébral, l'épilepsie, des crises épileptiques et des maladies oculaires et leurs troubles ou leurs symptômes.
PCT/US2012/025627 2011-02-17 2012-02-17 Composés dérivés de l'acide valproïque WO2012121862A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161444009P 2011-02-17 2011-02-17
US61/444,009 2011-02-17

Publications (2)

Publication Number Publication Date
WO2012121862A2 WO2012121862A2 (fr) 2012-09-13
WO2012121862A3 true WO2012121862A3 (fr) 2012-11-15

Family

ID=46798691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/025627 WO2012121862A2 (fr) 2011-02-17 2012-02-17 Composés dérivés de l'acide valproïque

Country Status (1)

Country Link
WO (1) WO2012121862A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015168614A2 (fr) * 2014-05-01 2015-11-05 Board Of Regents Of The University Of Nebraska Compositions polymères d'inhibiteurs de l'histone déacétylase et leurs méthodes d'utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037055A1 (fr) * 1998-12-18 2000-06-29 Abbott Laboratories Preparation a liberation controlee de divalproex sodium
US20020115718A1 (en) * 2001-02-16 2002-08-22 Andrx Corporation Divalproex sodium tablets
US20040258753A1 (en) * 2001-12-21 2004-12-23 Jo Demeester Pulsed bio-agent delivery systems based on degradable polymer solutions or hydrogels

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037055A1 (fr) * 1998-12-18 2000-06-29 Abbott Laboratories Preparation a liberation controlee de divalproex sodium
US20020115718A1 (en) * 2001-02-16 2002-08-22 Andrx Corporation Divalproex sodium tablets
US20040258753A1 (en) * 2001-12-21 2004-12-23 Jo Demeester Pulsed bio-agent delivery systems based on degradable polymer solutions or hydrogels

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PRAVEEN, B. ET AL.: "In-Vitro release and pharmacological study of synthesized valproic acid-dextran conjugate", ACTA PHARMACEUTICA SCIENCIA, vol. 51, 2009, pages 169 - 176 *

Also Published As

Publication number Publication date
WO2012121862A2 (fr) 2012-09-13

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