WO2012114062A1

WO2012114062A1 - Sanitising composition

Info

Publication number: WO2012114062A1
Application number: PCT/GB2012/000157
Authority: WO
Inventors: Peter Finan
Original assignee: Mtp Innovations Limited
Priority date: 2011-02-23
Filing date: 2012-02-15
Publication date: 2012-08-30
Also published as: EP2710107A1

Abstract

The present invention relates to a sanitising composition comprising a carrier comprising a cyclic polysiloxane, the composition further including an active sanitising ingredient system.

Description

SANITISING COMPOSITION

This invention relates to sanitising compositions. More particularly, but not exclusively, this invention relates to sanitising compositions in the form of gels. Embodiments of the invention relate to sanitising compositions for use in cleaning the skin, particularly the skin of a person's hands.

It is known to provide cleaning gels in hospitals to attempt to deal with pathogens, such as MRSA and Clostridium difficile. Such sanitising gels generally comprise sodium laureth sulphate and cocamidopropyl betaine, and may include anti-bacterial ingredients, such as triclosan, triclocarban and polyhexamethylene biguanide. Also, many known hand gels use an alcohol base. However, they are not entirely satisfactory in performance.

According to one aspect of this invention, there is provided a sanitising composition comprising a carrier comprising a cyclic polysiloxane, and the composition further including an active sanitising ingredient system.

According to another aspect of this invention, there is provided a method of manufacturing a sanitising composition comprising providing a carrier comprising a cyclic polysiloxane and mixing an active sanitising ingredient system therewith.

The cyclic polysiloxane may comprise one or more selected from cyclotetrasiloxane and cyclopentasiloxane. Preferably the cyclic polysiloxane is cyclopentasiloxane. In the embodiment described herein, the use of a cyclic polysiloxane has the advantage that the sanitising composition can be applied to the skin of a person in a smooth, even manner. The cyclic polysiloxane also provides the advantage in the embodiment described herein, that it evaporates leaving behind the active ingredient. The active sanitising ingredient system may comprise a cationic ingredient. The active sanitising ingredient system may comprise one or more quaternary ammonium compounds. Preferably the active sanitising ingredient system comprises at least two, for example three, different quaternary ammonium compounds. The quaternary ammonium compounds may be selected from the group consisting of polyaminopropyl biguanide, didecyldimethyl ammonium chloride and benzalkonium chloride.

The active sanitising ingredient system may comprise one or more active sanitising ingredient components selected from polyaminopropyl biguanide, didecyl dimethyl ammonium chloride, chlorhexidine digluconate and benzalkonium chloride.

The active sanitising ingredient system may further comprise a chlorophenol. The cholorophenol may be selected from the group consisting of 2,4,6-Trichlorophenol, Pentachlorophenol, 4-chloro-3-methylphenol (chlorocresol), PCMX (4-chloro-3,5- dimethylphenol, or para-chloro-meta-xylenol), DCMX (2,4-dichloro-3,5-dimethylphenol, or dichloro-meta-xylenol), PCMC (4-chloro-3-methylphenol, or para-chloro-meta-cresol) Monochloro-2-phenylphenol, OBPCP (2-benzyl-4-chlorophenol, or chlorphen, or ortho- benzyl-para-chlorophenol) and 2,4-dichlorobenzyl alcohol. Preferably the chlorophenol component is parachlorometaxylenol (PCMX) (otherwise known as chloroxylenol). In the embodiment described herein, the use of PCMX provides a secondary mode of

antimicrobial action in the composition to complement the traditional quaternary

ammonium compounds present. The active sanitising ingredient system may further comprise a water soluble ether and/or alcohol component. Where the active sanitising ingredient system comprises a water soluble alcohol component, the alcohol is preferably not ethanol or isopropyl alcohol, for example the water soluble alcohol component may be butanol. Preferably the active sanitising ingredient system comprises a water soluble ether alcohol component for example methoxymethylbutanol. Thus in one embodiment, the active sanitising ingredient system comprises methoxymethylbutanol. In the embodiment described herein, the use of methoxymethylbutanol acts as a solvent for the PCMX component thus enabling it to be added to the aqueous phase. The methoxymethylbutanol also aids the smoothness of the sanitising composition by aiding the aqueous solubility of the other components, in particular the Polyquaternium-37 thickening component (see below), and enabling the sanitising composition to be made as a cold blend. The active sanitising ingredient system may comprise one or more active sanitising ingredient components selected from polyaminopropyl biguanide, didecyl dimethyl ammonium chloride, benzalkonium chloride and parachlorometaxylenol. In one embodiment, the active sanitising ingredient system may comprise a mixture of polyaminopropyl biguanide, didecyl dimethyl ammonium chloride, benzalkonium chloride and parachlorometaxylenol.

In a preferred aspect, the invention provides a sanitising composition comprising a carrier comprising a cyclic polysiloxane, and the composition further including an active sanitising ingredient system and wherein the active sanitising system includes two or more quaternary ammonium compounds selected from polyaminopropyl biguanide, didecyldimethyl ammonium chloride and benzalkonium chloride and wherein the active sanitising system further includes parachlorometaxylenol.

In one embodiment, the invention provides a sanitising composition comprising a carrier comprising a cyclic polysiloxane, the composition further including an active sanitising ingredient system and wherein the active sanitising system includes polyaminopropyl biguanide, didecyldimethyl ammonium chloride and benzalkonium chloride and wherein the active sanitising system further includes parachlorometaxylenol and optionally methoxymethylbutanol .

The sanitising composition may further comprise a chelating agent, for example EDTA. The EDTA salt may potentiate the antimicrobial effect of the one or more active sanitising ingredient components. Preferably the EDTA salt is dipotassium EDTA dihydrate.

The active sanitising ingredient system may be present in the sanitising composition in an amount in the range of 0.05 wt. % to 2.5 wt. %, desirably 1.5 wt. % to 2.5 wt. %, and advantageously substantially 2.05 wt. %.

The polyaminopropyl biguanide may be present in the sanitising composition in an amount in the range 0.05 wt. % to 1.0 wt. %, desirably 0.3 wt. % to 0.5 wt. % and advantageously substantially 0.4 wt. %. The polyaminopropyl biguanide may be present in the sanitising composition in an amount in the range 0.01 wt. % to 0.3 wt. %. The didecyl dimethyl ammonium chloride may be present in the sanitising composition in an amount in the range 0.05 wt. % to 1.0 wt. %, desirably 0.3 wt. % to 0.5 wt. % and advantageously substantially 0.4 wt. %. The didecyl dimethyl ammonium chloride may be present in the sanitising composition in an amount in the range 0.01 wt. % to 0.4 wt. %.

The chlorhexidine digluconate may be present in the sanitising composition in an amount in the range 0.05 wt. % to 1.0 wt. %, desirably 0.4 wt. % to 0.6 wt. % and advantageously substantially 0.5 wt. %.

The benzalkonium chloride may be present in the sanitising composition in an amount in the range 0.01 wt. % to 0.2 wt. %, desirably 0.05 wt. % to 0.15 wt. % and advantageously substantially 0.1 wt. %. The benzalkonium chloride may be present in the sanitising composition in an amount in the range 0.01 wt. % to 0.1 wt. %.

The benzalkonium chloride may have a carbon chain length of C₁₂ to C₁₆.

The chlorophenol (e.g. parachlorometaxylenol) may be present in the sanitising composition in an amount in the range 0.01 wt. % to 2 wt. %, desirably 0.01 wt. % to 0.2 wt. %, for example 0.01 wt. % to 0.1 wt. %, and advantageously substantially 0.094 wt. %.

The methoxymethylbutanol may be present in the sanitising composition in an amount in the range 0.01wt% to 90wt%, desirably 0.01 wt. % to 20 wt. %, for example 1 wt. % to 10 wt. % and advantageously substantially 8.1 wt. %.

In one embodiment of this invention, the sanitising composition may be in the form of a gel, such as a hand gel.

The sanitising composition may include a thickener, which may be miscible in a

hydrophobic medium and in a hydrophilic medium. The thickener may comprise a hydrophilic thickener component, which may be cationic. The hydrophilic thickener component may comprise a polyquaternium substance. Desirably, the hydrophilic thickener component may comprise polyquaternium-37 (for example sold under the trade name Kleasol 100XT). The thickener may also constitute a film forming substance. The thickener may comprise a hydrophobic thickener component, which may be non-ionic. The hydrophobic thickener component may comprise an ethylene oxide/propylene oxide copolymer. The hydrophobic thickener component may comprise PEG PPG- 19/ 19 dimethicone (for example sold under the trade name, DC BY 1 1-030).

The thickener may be present in the composition in an amount in the range of 0.05 wt. % to 5.0 wt. %, desirably 2.0 wt. % to 4.0 wt. %, and advantageously substantially 2.75 wt. %. The hydrophilic thickener component may be present in the sanitising composition in an amount in the range 0.05 wt. % to 5.0 wt. %, desirably 1.0 wt. % to 2.0 wt. % and advantageously substantially 1.5 wt. %.

The hydrophobic thickener component may be present in the sanitising composition in an amount in the range 0.05 wt. % to 3.0 wt. %, desirably 0.5 wt. % to 2.0 wt. % and advantageously substantially 1.25 wt. %.

The sanitising composition may include a physiological coolant for example menthyl lactate.

The physiological coolant may be present in the sanitising composition in an amount in the range 0.05 wt. % to 1.0 wt. %, desirably 0.1 wt. % to 0.5 wt. % and advantageously substantially 0.25 wt. %. The sanitising composition may include other ingredients, such as colorants and/or fragrances.

Preferably the sanitising composition does not contain ethanol and/or isopropyl alcohol (IPA).

There is thus described a sanitising composition, which is in the form of an alcohol-free, specifically ethanol and isopropyl alcohol (IPA)-free, hand gel. The invention further provides a hand gel comprising a sanitising composition according to the invention. In one embodiment, the hand gel comprises a sanitising composition comprising a cyclic polysiloxane, a thickener and an active sanitising ingredient system wherein the active sanitising system includes polyaminopropyl biguanide, didecyldimethyl ammonium chloride and benzalkonium chloride and wherein the active sanitising system further includes parachlorometaxylenol and optionally methoxymethylbutanol.

A further aspect of the invention provides a sanitising composition, which is in the form of an alcohol-free, specifically ethanol and isopropyl alcohol (IPA)-free, liquid, spray or foam. Thus, in one embodiment, the sanitising composition comprising a cyclic polysiloxane and an active sanitising ingredient system wherein the active sanitising system includes polyaminopropyl biguanide, didecyldimethyl ammonium chloride and benzalkonium chloride and wherein the active sanitising system further includes parachlorometaxylenol and optionally methoxymethylbutanol. The sanitising composition may be used to impregnate a textile substrate. Thus the invention encompasses a sanitising wipe, such as a hand wipe, or tissue comprising a sanitising composition according to the invention. Thus, a further aspect of the invention provides a hand wipe comprising a sanitising composition according to the invention. The method may comprise forming a hydrophilic component system comprising water and an active ingredient. The method may comprise forming a hydrophobic component system comprising a cyclic polysiloxane. The method may comprise mixing the hydrophilic component system and the hydrophobic component system with each other. The step forming the hydrophilic component system may comprise mixing a hydrophilic component thickener with the water and the active sanitising ingredient system. The step of forming the hydrophobic component system may comprise mixing the hydrophobic thickener component with the cyclic polysiloxane. The step of forming the hydrophilic component system may comprise mixing the hydrophilic thickener component with water. This step may comprise sprinkling the hydrophilic thickener component in a vessel containing water. The water may be continuously stirred during said mixing. The method of forming the hydrophilic component system may comprise mixing each active sanitising ingredient component sequentially in the water. The step of mixing each active sanitising ingredient component sequentially may be performed after the mixing of the hydrophilic thickener component with the water.

The step of forming the hydrophobic component system may comprise adding the hydrophobic thickener component to the cyclic polysiloxane. The step of forming the hydrophobic component system may comprise adding the physiological coolant to the cyclic polysiloxane, desirably after mixing the hydrophobic thickener component with the cyclic polysiloxane. At least one embodiment of the invention will now be described by way of example only.

A sanitising composition in the form of an ethanol and IPA-free hand sanitising gel is described herein. The sanitising composition comprises a carrier in the form of a cyclic polysiloxane, and an active sanitising ingredient system.

The cyclic polysiloxane may be cyclotetrasiloxane and/or cyclopentasiloxane. Suitable cyclotetrasiloxanes and cyclopentasiloxanes are sold by the company Dow Xiameter. In the examples below, the cyclotetrasiloxane used is sold under the trade mark Xiameter PMX0244 and the cyclopentasiloxane used is sold under the trade mark Xiameter PMX0245.

In Example 1 described below, the carrier is in the form of cyclotetrasiloxane, and is present in the sanitising composition in an amount of substantially 1.0 wt. %. The active sanitising ingredient system may comprise one or more of the following active sanitising ingredient components: polyaminopropyl biguanide. didecyl dimethyl ammonium chloride, chlorhexidine digluconate and benzalkonium chloride. One embodiment of the invention includes a mixture of each of the above active sanitising ingredient components. Polyaminopropyl biguanide is commercially available as a 20 wt. % solution in water, and is sold under various the trade marks, such as, Vantocil TG and Acticide PHB20. In the example described below, polyaminopropyl biguanide is present in an amount of substantially 0.3 wt. %. Thus, the amount of the commercially available aqueous solution used in the embodiment described below is substantially 1.5 wt. %. Didecyl dimethyl ammonium chloride is commercially available as a 50 wt. % solution in water, and is sold under various the trade marks, such as, Bardac 22 and Acticide DDQ40. In the example described below, didecyl dimethyl ammonium chloride is present in an amount of substantially 0.4 wt. %. Thus, the amount of the commercially available aqueous solution used in the embodiment described below is substantially O.g wt. %.

Chlorhexidine digluconate is commercially available as a 20 wt. % solution in water, and is sold by the company Sigma Aldrich. In the example described below, chlorhexidine digluconate is present in an amount of substantially 0.5 wt. %. Thus, the amount of the commercially available aqueous solution used in the embodiment described below is substantially 2.5 wt. %.

Benzalkonium chloride is commercially available as a 50 wt. % solution in water, and is sold under various the trade marks, such as, Surfachem BAC50 and Acticide BAC50. In the example described below, benzalkonium chloride is present in an amount of substantially 0.1 wt. %. Thus, the amount of the commercially available aqueous solution used in the embodiment described below is substantially 0.2 wt. %. The benzalkonium chloride has a carbon chain length of C₁₂ to C₁₆.

The sanitising composition comprises a thickener, which is formed of a hydrophilic thickener component and a hydrophobic thickener component. The hydrophilic thickener component is present in the sanitising composition in an amount of substantially 1.5 wt. %. The hydrophobic thickener component is present in the sanitising composition in an amount of substantially 2.5 wt. %.

The hydrophilic thickener component comprises a cationic thickener component, and is in the form of polyquaternium-37. A suitable such hydrophilic thickener component is sold under the trade mark Synthalen CR, manufactured by Coast Southwest, Placentia, CA, USA.

The hydrophobic thickener component comprises a non-ionic thickener component and is in the form of PEG/PPG- 19/19 Dimethicone. A suitable such hydrophobic thickener component is sold by Dow Corning under the trade mark DC BY 1 1-030, and is in the form of a solution of PEG/PPG- 19/19 Dimethicone in cyclopentasiloxane, and partially provides the composition with its cyclopentasiloxane content.

The sanitising composition includes a physiological coolant, in the form of menthyl lactate. The physiological coolant provides a cooling effect on the skin during use of the composition.

The physiological coolant is added in a crystalline form. A suitable such physiological coolant is sold under the trade mark Frescolat ML Crystals 399952 by Symrise. The amount of physiological coolant present in the sanitising composition is substantially 2.5 wt. %.

Example 1

A hydrophilic component system is formed, comprising the following:

Ingredients Amount present

in composition (wt. %) Water (cold) 93.45

Polyquaternium-37 (cationic thickener) 1.5

Polyaminopropyl Biguanide (active sanitising ingredient)

(20% aqueous solution) 0.3

Didecyl dimethyl ammonium chloride (active sanitising ingredient)

(50% aqueous solution) 0.4

Benzalkonium Chloride (active sanitising ingredient)

(50% aqueous solution) 0.1

Chlorhexidine Digluconate (active sanitising ingredient)

(20% aqueous solution) 0.5 The method of forming the hydrophilic component system comprises adding the cold water to a vessel. The polyquaternium-37 is then slowly sprinkled into the water in the vessel, while continuously mixing. The polyquaternium-37 is allowed to completely hydrate and solubilise. Thereafter, the active sanitising ingredients are added sequentially with continuous mixing between the additions of each active sanitising ingredient. A hydrophobic component system is also formed, comprising the following:

Ingredient Amount present

in composition fwt. %)

Cyclotetrasiloxane (carrier) 1.0

PEG/PPG- 19/19 Dimethicone (hydrophobic thickener)

(50% solution in cyclopentasiloxane) 1.25

Cyclopentasiloxane ( as solvent from above hydrophobic

thickener solution) 1.25

Menthyl Lactate (physiological coolant)

(In crystal form) 0.25

The method of forming the hydrophobic component system comprises adding the cyclotetrasiloxane to a vessel. The PEG/PPG-19/19 Dimethicone is then dissolved in the cyclotetrasiloxane while continuously stirring. Thereafter, the menthyl lactate crystals are added, also with continuous stirring.

After the hydrophilic component system and the hydrophobic component system have been prepared, the hydrophilic and the hydrophobic component systems are added to each other, with continuous stirring until a smooth homogeneous gel is produced.

There is thus described an embodiment of a sanitising composition, which is in the form of an alcohol-free sanitising hand gel. The sanitising hand gel meets the requirements of EN1 00 - the prescribed test for hygienic hand-rubs, by achieving a log. 5 reduction of bacteria in the test or a performance equivalent to a reference material (Isopropyl alcohol).

Example 2

The product is made in two phases. Firstly, a pre-mix containing non- water soluble ingredients is made. Secondly, an aqueous phase is made, to which is finally added the aqueous-phase pre-mix. Ingredient %w/w

Water (at 40c) 82.55%

Dipotassium EDTA 0.10%

Methoxymethylbutanol 5.00%

Acticide PHB20 1.50%

Kleasol 100XT 1.70%

Acticide DDQ40 1.00%

Acticide BAC50M 0.20%

Preservative 0.50%

Pre-mix (see below) 7.45%

Pre-mix for above blend

Ingredient %w/w

Methoxymethylbutanol 41.69%

PCMX 1.26%

Xiameter PMX 0245 23.49%

DC BY 11-030 33.56%

For the pre-mix manufacture: a suitable vessel is charged with the Methoxymethylbutanol. The PCMX is added, and stirred until completely dissolved. The Xiameter PMX 0245 is added and stirred until completely assimilated and a homogenous clear solution is obtained. Finally, the DC BY 11-030 is added and stirred until completely assimilated and a homogenous clear solution is obtained. This pre-mix is then set aside to be added at the end of the aqueous phase.

For the aqueous phase, a suitable vessel is charged with the water (cold mains water or softened is acceptable). The Dipotassium EDTA is added and the solution stirred until all the Dipotassium EDTA has dissolved. The Methoxymethylbutanol is then added and stirred until the solution is clear and homogenous. The Acticide PHB20 is then added and the solution is stirred until the solution is clear and homogenous. The Kleasol 100XT is then added slowly by sprinkling into the solution with constant stirring. Stirring is maintained until the Kleasol has fully swollen and finally dissolved to give a more viscous solution, and until there is no undissolved material or 'fish-eyes' visible in the solution. Next, the

Acticide DDQ40 is added and the solution stirred until all has been assimilated and the product is homogenous. Then the Acticide BAC50M is added and the solution stirred until all has been assimilated and the product is homogenous. Subsequently the Phenoxyethanol is added slowly and with constant stirring until it has been assimilated and the product is homogenous. At this point, the product may go slightly more opaque. Finally, the required amount of pre-mix (previously made and set aside) is added slowly and with constant stirring. Stirring is continued until the product is smooth and homogenous, and when all the pre-mix has been assimilated. The product may rise in viscosity due to the extra thicker in the non-aqueous phase being added.

Acticide PHB20: this is a 20% aqueous solution of Polyhexamethylene Biguanide

Acticide DDQ40: this is a 40% aqueous solution of Didecyldimethylammonium Chloride Acticide BAC50M: this is a 50% solution of the very widely used antimicrobial compound Benzalkonium Chloride.

The three compounds listed immediately above are commonly referred to as Quaternary ammonium compounds, and are commonly used disinfectant compounds. It has been found that the combination of two or more of the above compounds gives a surprisingly better antimicrobial performance than any one on its own.

Various modifications can be made without departing from the scope of the invention. For example, the sanitising composition may include other ingredients, such as colorants and/or fragrances.

Example 3

An unthickened formulation is prepared as follows: Phase 1 :

Water - 88.71%

Dipotassium EDTA Dihydrate - ).10%

Phase 2: Methoxymethylbutanol - 8.10%

PCMX - 0.09%

Acticide DDQ 40 - 1.00%

Acticide BAC 50M - 0.20%

Acticide PHB20 - 1.50%

Preservative - 0.30%

Phases 1 and 2 are made separately then phase 2 is slowly added to phase 1 with constant stirring.

This formulation is suitable for dispensing as a liquid, spray, for example an aerosol, a hand wipe or a foam.

Claims

1. A sanitising composition comprising a carrier comprising a cyclic polysiloxane, the composition further including an active sanitising ingredient system.

2. A sanitising composition according to claim 1 wherein the cyclic polysiloxane is selected from cyclotetrasiloxane and cyclopentasiloxane.

3. A sanitising composition according to claim 2 wherein the cyclic polysiloxane is cyclopentasiloxane.

4. A sanitising composition according to any preceding claim further comprising a cationic ingredient.

5. A sanitising composition according to any preceding claim further comprising one or more quaternary ammonium compounds.

6. A sanitising composition according to any preceding claim further comprising one or more active sanitising ingredient components selected from polyaminopropyl biguanide, didecyl dimethyl ammonium chloride and benzalkonium chloride.

7. A sanitising composition according to claim 7 comprising a mixture of polyaminopropyl biguanide, didecyl dimethyl ammonium chloride and benzalkonium chloride.

8. A sanitising composition according to any preceding claim wherein the active sanitising ingredient system is present in the sanitising composition in an amount in the range of 0.05 wt. % to 2.5 wt. %

9. A sanitising composition according to claim 8 wherein the active sanitising ingredient system is present in the sanitising composition in an amount in the range of desirably 1.5 wt. % to 2.5 wt. %,

10. A sanitising composition according to claim 6 or 7 wherein the polyaminopropyl biguanide is present in the sanitising composition in an amount in the range 0.01 wt. % to 0.3 wt. %.

11. A sanitising composition according to claim 6 or 7 wherein the didecyl dimethyl ammonium chloride is present in the sanitising composition in an amount in the range 0.01 wt. % to 0.4 wt. %.

12. A sanitising composition according to claim 6 or 7 wherein the benzalkonium chloride may be present in the sanitising composition in an amount in the range 0.01 wt. % to 0.1 wt. %.

13. A sanitising composition according to any preceding claim further comprising a chlorophenol.

14. A sanitising composition according to claim 13 wherein the chlorophenol is parachlorometaxylenol .

15. A sanitising composition according to claim 14 wherein the chlorophenol is present in the sanitising composition in an amount in the range 0.01 wt. % to 2.0 wt. %.

16. A sanitising composition according to any preceding claim further comprising methoxymethy lbutanol .

17. A sanitising composition according to claim 16 wherein the methoxymethylbutanol is present in the sanitising composition in an amount in the range 0.01 wt. % to 90 wt. %.

18. A sanitising composition according to any preceding claim further comprising a thickener.

19. A sanitising composition according to claim 18 wherein the thickener is miscible in a hydrophobic medium and in a hydrophilic medium.

20. A sanitising composition according to claim 19 wherein the thickener comprises a hydrophilic thickener component which is cationic.

21. A sanitising composition according to claim 20 wherein the hydrophilic thickener component comprises a polyquaternium substance.

22. A sanitising composition according to claim 21 wherein the hydrophilic thickener component comprise polyquaternium-37.

23. A sanitising composition according to claim 18 wherein the thickener comprises a hydrophobic thickener component which is non-ionic.

24. A sanitising composition according to claim 23 wherein the hydrophobic thickener component comprises an ethylene oxide/propylene oxide co-polymer.

25. A sanitising composition according to claim 24 wherein the hydrophobic thickener component comprises PEG/PPG- 19/19 dimethicone.

26. A sanitising composition according to any one of claims 18 to 25 wherein the thickener is present in the composition in an amount in the range of 0.05 wt. % to 5.0 wt. %.

27. A sanitising composition according to any preceding claim wherein the sanitising composition is in the form of a gel.

28. A hand gel comprising a sanitising composition according to any one of claims 1 to 27.

29. A hand gel according to claim 28 wherein the hand gel comprises a sanitising composition comprising a cyclic polysiloxane, a thickener and an active sanitising ingredient system wherein the active sanitising system includes polyaminopropyl biguanide, didecyldimethyl ammonium chloride and benzalkonium chloride and wherein the active sanitising system further includes parachlorometaxylenol and optionally methoxymethylbutanol .

30. A sanitising composition according to any one of claims 1 to 17 comprising a cyclic polysiloxane and an active sanitising ingredient system wherein the active sanitising system includes polyaminopropyl biguanide, didecyldimethyl ammonium chloride and benzalkonium chloride and wherein the active sanitising system further includes parachlorometaxylenol and optionally methoxymethylbutanol.

31. A sanitising wipe, such as a hand wipe, comprising a sanitising composition according to claim 30.

32. A method of manufacturing a sanitising composition comprising providing a carrier comprising a cyclic polysiloxane and mixing an active sanitising ingredient system therewith.

33. A method according to claim 32 wherein the method comprises forming a hydrophilic component system comprising water and an active ingredient, forming a hydrophobic component system comprising a cyclic polysiloxane, and mixing the hydrophilic component system and the hydrophobic component system with each other.