WO2012112842A3 - Compositions et procédés pour traiter le poliovirus - Google Patents
Compositions et procédés pour traiter le poliovirus Download PDFInfo
- Publication number
- WO2012112842A3 WO2012112842A3 PCT/US2012/025571 US2012025571W WO2012112842A3 WO 2012112842 A3 WO2012112842 A3 WO 2012112842A3 US 2012025571 W US2012025571 W US 2012025571W WO 2012112842 A3 WO2012112842 A3 WO 2012112842A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- poliovirus
- methods
- compositions
- treating
- antigen
- Prior art date
Links
- 241000991587 Enterovirus C Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 241000282577 Pan troglodytes Species 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 208000025223 poliovirus infection Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1009—Picornaviridae, e.g. hepatitis A virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne des anticorps chimériques chimpanzé/humain et leurs fragments de liaison à l'antigène qui sont capables de neutraliser le poliovirus. En outre, elle concerne également des procédés d'utilisation des anticorps et de leurs fragments de liaison à l'antigène pour prévenir et traiter une infection par le poliovirus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161443915P | 2011-02-17 | 2011-02-17 | |
US61/443,915 | 2011-02-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012112842A2 WO2012112842A2 (fr) | 2012-08-23 |
WO2012112842A3 true WO2012112842A3 (fr) | 2013-01-31 |
Family
ID=45953219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/025571 WO2012112842A2 (fr) | 2011-02-17 | 2012-02-17 | Compositions et procédés pour traiter le poliovirus |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012112842A2 (fr) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1975A (en) | 1841-02-12 | Manner of constructing corn-shellers | ||
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
-
2012
- 2012-02-17 WO PCT/US2012/025571 patent/WO2012112842A2/fr active Application Filing
Non-Patent Citations (5)
Title |
---|
CHEN ZHAOCHUN ET AL: "Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 103, no. 6, 7 February 2006 (2006-02-07), pages 1882 - 1887, XP002389476, ISSN: 0027-8424, DOI: 10.1073/PNAS.0510598103 * |
CHEN ZHAOCHUN ET AL: "Chimpanzee-human monoclonal antibodies for treatment of chronic poliovirus excretors and emergency postexposure prophylaxis.", JOURNAL OF VIROLOGY MAY 2011 LNKD- PUBMED:21345966, vol. 85, no. 9, May 2011 (2011-05-01), pages 4354 - 4362, XP002682219, ISSN: 1098-5514 * |
CHU C-T ET AL: "A HUMAN-HUMAN HYBRIDOMA WHICH PRODUCES ANTIBODIES TO POLIOVIRUSES", PROCEEDINGS OF THE NATIONAL SCIENCE COUNCIL REPUBLIC OF CHINA PART B LIFE SCIENCES, vol. 13, no. 4, 1989, pages 284 - 288, XP009162216, ISSN: 0255-6596 * |
SCHOFIELD D J ET AL: "Four chimpanzee monoclonal antibodies isolated by phage display neutralize hepatitis a virus.", VIROLOGY 5 JAN 2002 LNKD- PUBMED:11878915, vol. 292, no. 1, 5 January 2002 (2002-01-05), pages 127 - 136, XP002965366, ISSN: 0042-6822 * |
UHLIG H ET AL: "Intertypic cross-neutralization of polioviruses by human monoclonal antibodies", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 163, no. 1, 1 March 1988 (1988-03-01), pages 214 - 217, XP023047507, ISSN: 0042-6822, [retrieved on 19880301], DOI: 10.1016/0042-6822(88)90251-6 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012112842A2 (fr) | 2012-08-23 |
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