WO2012106632A1 - Biomarqueurs pour la détermination d'un phénotype tolérant l'allogreffe - Google Patents

Biomarqueurs pour la détermination d'un phénotype tolérant l'allogreffe Download PDF

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Publication number
WO2012106632A1
WO2012106632A1 PCT/US2012/023829 US2012023829W WO2012106632A1 WO 2012106632 A1 WO2012106632 A1 WO 2012106632A1 US 2012023829 W US2012023829 W US 2012023829W WO 2012106632 A1 WO2012106632 A1 WO 2012106632A1
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WO
WIPO (PCT)
Prior art keywords
gene
subject
expression
genes
graft
Prior art date
Application number
PCT/US2012/023829
Other languages
English (en)
Inventor
Minnie M. Sarwal
Li Li
Samuel Strober
Original Assignee
The Board Of Trustees Of The Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Publication of WO2012106632A1 publication Critical patent/WO2012106632A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

L'invention concerne des procédés permettant de déterminer si un sujet présente un phénotype tolérant une greffe. Par la mise en œuvre des procédés de l'invention, le niveau d'expression d'un ou plusieurs gènes dans un échantillon provenant du sujet, par exemple, un échantillon sanguin, est dosé pour obtenir un résultat d'expression génique, le résultat d'expression génique comprenant un résultat pour un biomarqueur de tolérance de greffe. Le résultat d'expression génique obtenu est ensuite utilisé pour déterminer si le sujet présente un phénotype tolérant une greffe. L'invention concerne également des compositions, des systèmes et des trousses qui sont utiles dans la mise en œuvre des procédés de l'invention. Les procédés et compositions sont utiles dans une variété d'applications, notamment la détermination d'un régime thérapeutique immunosuppresseur.
PCT/US2012/023829 2011-02-03 2012-02-03 Biomarqueurs pour la détermination d'un phénotype tolérant l'allogreffe WO2012106632A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161439288P 2011-02-03 2011-02-03
US61/439,288 2011-02-03

Publications (1)

Publication Number Publication Date
WO2012106632A1 true WO2012106632A1 (fr) 2012-08-09

Family

ID=46603100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/023829 WO2012106632A1 (fr) 2011-02-03 2012-02-03 Biomarqueurs pour la détermination d'un phénotype tolérant l'allogreffe

Country Status (1)

Country Link
WO (1) WO2012106632A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114496279A (zh) * 2022-01-12 2022-05-13 广州保量医疗科技有限公司 菌群移植配型的排序方法、系统、计算机设备及存储介质

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060088876A1 (en) * 2004-08-03 2006-04-27 Bauer A R Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
US20060246485A1 (en) * 2005-03-14 2006-11-02 Sarwal Minnie S Methods and compositions for evaluating graft survival in a solid organ transplant recipient

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060088876A1 (en) * 2004-08-03 2006-04-27 Bauer A R Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
US20060246485A1 (en) * 2005-03-14 2006-11-02 Sarwal Minnie S Methods and compositions for evaluating graft survival in a solid organ transplant recipient

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEE ET AL.: "Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival.", J. IMMUNOL., vol. 174, no. 8, 15 April 2005 (2005-04-15), pages 4535 - 4544 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114496279A (zh) * 2022-01-12 2022-05-13 广州保量医疗科技有限公司 菌群移植配型的排序方法、系统、计算机设备及存储介质
CN114496279B (zh) * 2022-01-12 2022-08-30 广州保量医疗科技有限公司 菌群移植配型的排序方法、系统、计算机设备及存储介质

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