WO2012104642A1 - Method for predicting risk of developing cancer - Google Patents

Method for predicting risk of developing cancer Download PDF

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Publication number
WO2012104642A1
WO2012104642A1 PCT/GB2012/050221 GB2012050221W WO2012104642A1 WO 2012104642 A1 WO2012104642 A1 WO 2012104642A1 GB 2012050221 W GB2012050221 W GB 2012050221W WO 2012104642 A1 WO2012104642 A1 WO 2012104642A1
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cancer
risk
genes
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breast cancer
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PCT/GB2012/050221
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French (fr)
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Martin Widschwendter
Andrew TESCHENDORFF
Ian Jacobs
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Ucl Business Plc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Definitions

  • the invention relates to predicting the risk in a subject of developing cancer, in particular breast cancer.
  • the invention also relates to the selection of subjects suitable for prophylactic treatment of cancer.
  • Breast cancer is the most common cancer affecting at least 1 in 10 women in the western world. Predicting the risk and offering preventive measures has been demonstrated to be an effective intervention in women with an inherited breast cancer predisposition. In particular, in screening programs clinicians currently use guidelines that recommend the identification of carriers of BRCAl and BRCA2 mutations, which confer very high risks of breast cancer and ovarian cancer. However, BRCAl/2 mutations only account for approximately 10% of breast cancers. About 90% of breast cancers are sporadic and only about 10% inherited. Predicting the likelihood of developing breast cancer is therefore particularly important for women who have no particular family history of the condition.
  • breast cancer Many traditional risk factors have been defined for breast cancer, for example age, geographic location, previous breast cancer, previous benign breast disease and reproductive history. Other factors such as diet, alcohol consumption, socioeconomic group and family history can also be considered. While modification of personal habits, reproductive considerations, and behavior can reduce risk, the benefits are modest and certainly offer no guarantees.
  • ROC receiver- operating-characteristic
  • the present inventors have found that assessment of a healthy individual's DNA methylation profile up to several years in advance of any subsequent diagnosis of cancer has the potential to predict that individual's risk of developing cancer.
  • the inventors have identified an aberrant DNA methylation profile in genes encoding developmental transcription factors required for the differentiation of stem or progenitor cells, as well as target genes of transcription factors that are involved in stem or progenitor cell differentiation, in individuals predisposed to cancer.
  • aberrant DNA methylation profiles are seen in genes that are required for the differentiation of stem or progenitor cells.
  • the genes in which aberrant methylation has been identified by the inventors include target genes of Nuclear Inhibitor of Protein Phosphatase- 1 (NIPP1), Msh homeobox 1 (MSX1) or NANOG, Polycomb- group target genes (PCGTs) and genes with an AACTTT promoter motif.
  • NIPP1 Nuclear Inhibitor of Protein Phosphatase- 1
  • MSX1 Msh homeobox 1
  • NANOG NANOG
  • PCGTs Polycomb- group target genes
  • genes with an AACTTT promoter motif genes with an AACTTT promoter motif.
  • target genes of NIPPl, MSXl or NANOG, Polycomb-group target genes (PCGTs) and/or genes with an AACTTT promoter motif can show a methylation profile that indicates a predisposition to developing cancer, such as breast cancer.
  • Such aberrant DNA methylation profiles can be seen in advance of any signs or clinical symptoms of cancer.
  • the present invention offers an advance indication of the risk of an individual dying from cancer, particularly breast cancer. This is the first time that a specific test performed on healthy individuals is not only indicative of the risk to develop cancer, but also the risk of whether an individual is more likely to die from the disease.
  • the present invention provides a method for predicting the risk in a subject of developing cancer, the method comprising:
  • a target gene of NIPPl, MSXl or NANOG, a polycomb group target gene (PCGT) or a gene with an AACTTT promoter motif or a gene with an AACTTT promoter motif
  • the invention further provides a method for selecting a subject suitable for preventative treatment of cancer, the method comprising:
  • Figure 1 outlines the study design and identification/validation of DNA methylation breast cancer risk profile.
  • A Flowchart depicting strategy used to derive and validate a serum DNA methylation based risk predictor of breast cancer.
  • B Histogram of P-values derived in discovery set.
  • C FDR estimation using q- value procedure: for each number of top ranked CpGs declared positive (x-axis) we plot the expected number of false positives (y-axis).
  • D Mean ROC curve, AUC and 95%CI for the 100 elastic net (ELNET) classifiers trained in the discovery set.
  • E Penalty parameter (log(lambda) x-axis) estimation using internal cross-validation procedure in the elastic net.
  • y-axis denotes error as a function of penalty parameter. Number of CpGs in classifier at each parameter value given on top axis.
  • F ROC curve, AUC and 95%CI of the ensemble ELNET classifier in the validation set.
  • FIG. 2 shows a Gene Set Enrichment Analysis (GSEA) of breast cancer risk signature.
  • GSEA Gene Set Enrichment Analysis
  • A GSEA of genes significantly hypermethylated in prospective cases. Enriched gene categories are sorted in a network according to their P-values of enrichment (dark to light shading indicates decreasing levels of significance). Edges between gene categories reflect significant overlap in the corresponding gene sets (as measured by Jaccard coefficient). Dark shading to light shading indicate decreasing levels of gene overlap. Pujana BRCA1 network is specially highly ranked when considering samples from prospective cases well before diagnosis.
  • CpGs and samples have been clustered using hierarchical clustering and a Pearson correlation metric.
  • the shaded bars denote the two main clusters (lighter bar on the left, darker bar on the right) and if sample is a case (black) or control (white). Distribution of cases/controls is given and associated P-value is that of a Fisher-test.
  • Right panel shows the enrichment of stem-cell related gene sets among CpGs hypermethylated in cases relative to controls. Dashed line separates hypermethylated from hypomethylated CpGs.
  • Figure 3 show a comparison of DNA methylation signature in cases diagnosed early and late after sample collection.
  • A Comparison of P-value histograms from the supervised multivariate regression analysis of methylation beta values against case control status, using 50 cases who were diagnosed early ( ⁇ 1.5 years since sample draw) (top left panel), and separately, using 50 cases who were diagnosed late (>2.5 years after sample draw).
  • B Left panel plots the t-statistics from the top 500 risk CpGs as derived from a multivariate regression using early diagnosed cases vs controls (x-axis) against their corresponding t-statistics using cases who were diagnosed later (defined as in panel A) (y-axis). Right panel shows the same plot but selecting the top 500 risk CpGs using cases who were diagnosed later.
  • Dark dots denotes significant hyper (hypo) methylated in cases of the first set.
  • the number of CpGs broken up according to their hypermethylated and hypomethylated pattern in early and late diagnosed cases is given, together with the associated Fisher-test P- value.
  • Figure 4 shows a breast cancer risk signature in non-neoplastic and cancerous breast and in peripheral blood cells from cancer-free BRCAl mutation carriers.
  • Boxplots show the average methylation levels of top cancer risk CpGs, hypermethylated (hyperM) and hypomethylated (hypoM) in prospective U CTOCS cases. The number of samples/data points in each boxplot are given on the bottom axis.
  • P-values are either from a linear regression (A) or from a Wilcoxon rank sum test (B). Tables give the distribution of the top hypermethylated and hypomethylated cancer risk CpGs according to whether hypermethylated or hypomethylated in breast cancer tissue or the blood samples from BRCAl mutation carriers. P-value is from a Fisher- test.
  • B Peripheral blood DNA samples of healthy BRCAl mutation carriers (mt-H) and age-matched healthy BRCAl wild type controls (wt-H).
  • Figure 5 is an enhanced version of Figure 2B, denoting information gained from at least 6 years of follow up since the sample was provided. Of the 180 women (134 in discovery and 48 in validation set) who developed breast cancer, 15 women died of breast cancer within six years after they provided the sample (indicated with additional vertical bars at the top of the discovery set).
  • Figure 6 shows a Kaplan Meier curve and likelihood ratio test pyalue derived from the data of Figure 5 : women who demonstrated a stem cell
  • hypermethylation profile had a higher chance of developing breast cancer 0.5 - 5 years after their sample was taken, but also demonstrated a substantially higher risk of dying from their breast cancer within 6 years.
  • the present invention relates to the assessment of a subject's DNA methylation status in target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) and/or genes with an AACTTT promoter motif and the use of this methylation status to predict the risk of developing cancer in that subject.
  • target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) and/or genes with an AACTTT promoter motif are required for the differentiation of stem or progenitor cells.
  • said one or more genes selected from target genes of NIPP1, MSXl or NANOG, polycomb group target genes (PCGT) and/or genes with an AACTTT promoter motif are involved in stem cell biology and/or the differentiation of stem cells.
  • these genes may encode developmental transcription factors needed for differentiation of stem cells, and/or are target genes of transcription factors that are involved in stem cell biology.
  • said one or more genes are required for the differentiation of stem or progenitor cells, for example stem or progenitor cells in breast tissue.
  • the genes of interest may be involved in the loss of pluripotency and proliferative potential and the development of a more specialized cell type.
  • NIPP1 is a transcriptional repressor and contributes to the recruitment of the Polycomb Repressor Complex (PRC2).
  • PCGTs are genes that are targeted by polycomb-group proteins such as PRC1, PRC2 and PhoRC.
  • Such Polycomb-group proteins act in a multiprotein complex to repress gene expression from the target gene, such as a target gene involved in differentiation of a stem cell.
  • MSXl is a transcriptional repressor involved in mammary development and breast cancer.
  • NANOG is a transcriptional factor known to maintain pluripotency of stem cells.
  • the genes of interest are genes required for the differentiation of stem or progenitor cells, the expression of which is regulated by either NIPP1, Polycomb-group proteins, MSXl and/or NANOG. Most preferably, the genes of interest are genes required for the differentiation of stem or progenitor cells, the expression of which is regulated by Polycomb-group proteins.
  • the genes of interest are genes with an AACTTT promoter motif that encode transcription factors required for the differentiation of stem or progenitor cells, for example stem or progenitor cells in breast tissue.
  • said one or more genes of interest are required for the differentiation of stem or progenitor cells and are selected from genes in Table 2 that are target genes of NIPP1, MSX1, NANOG or polycomb group proteins (PCGTs) or genes with an AACTTT promoter motif.
  • said one or more genes selected from Table 2 are required for the differentiation of stem or progenitor cells in breast tissue.
  • the DNA methylation status is assessed in 1 or more, 3 or more, 5 or more, or 10 or genes selected from Table 2 that are target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif.
  • PCGT polycomb group target genes
  • the DNA methylation status of 1 or more, 3 or more or 5 or more PCGTs selected from Table 2 are assessed.
  • the sample of genomic DNA may be obtained from any available source of tissue or cells isolated from the subject. This may include but is not limited to solid tissue samples, liquid tissue samples, biological fluids, aspirates, cells and cell fragments.
  • samples may be isolated from blood, serum, plasma, peripheral blood cells, cerebrospinal fluid, urine, fine needle aspirate, saliva, sputum, breast or other hormone dependent tissue, breast milk, bone marrow, skin, epithelia (including buccal, cervical or vaginal epithelia) or other tissue derived from the ectoderm.
  • the sample of genomic DNA comprises cells from a tissue that is involved in the type of cancer concerned.
  • the sample of genomic DNA is isolated from breast or other hormone dependent tissue, serum, peripheral blood cells, buccal epithelia, cervical epithelia or vaginal epithelia.
  • DNA methylation status Typically, an assessment of DNA methylation status involves analysing the presence or absence of methyl groups in DNA, for example methyl groups on the 5 position of one or more cytosine nucleotides.
  • the methylation status of one or more cytosine nucleotides present as a CpG dinucleotide is assessed.
  • C stands for Cytosine, G for Guanine and p for the phosphate group linking the two
  • CpG sites may occur in the promoter or regulatory regions of a gene of interest.
  • the methylation status of CpGs clustered in CpG islands is assessed, for example CpG islands present in the regulatory regions of genes, especially in their promoter regions.
  • a promoter is a nucleotide sequence, which initiates and regulates transcription of a polypeptide-encoding polynucleotide.
  • the genes used in the methods of the present invention may comprise further regulatory regions comprising one or more cytosine residues. Typically, such further regulatory regions provide additional levels of transcription control, for example ensuring cell specific gene expression or expression under certain conditions. Further regulatory regions, such as enhancer elements, may be downstream or upstream of the gene of interest or of the promoter.
  • the methylation of at least one, at least 2, at least 3, at least 5, at least 10 or at least 20 CpG sites is assessed in the regulatory region of one or more genes selected from target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif.
  • target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif are selected from Table 2.
  • it will be sufficient to assess one CpG per gene because the methylation status of one CpG in a CpG island tends to be representative of that of other CpGs in the island.
  • multiple CpGs per gene can also be assessed.
  • the methods of the invention may involve an assessment of the methylation of CpG sites in the genes of interest identified in Table 2.
  • Table 2 provides CpG loci identifiers under the column entitled "CpG". These CpG loci identifiers refer to individual CpG sites used in the commercially available Illumina® Infinium Human Methylation27 BeadChip kit. The identity of each CpG site represented by each CpG loci identifier is publicly available from the Illumina, Inc website under reference to the CpG sites used in the Infmium Human Methylation27 BeadChip kit. For example, the identity of each CpG site can be found under the link to
  • CpG Loci Identification A guide to Illumina 's method for unambiguous CpG loci identification and tracking for the Golden Gate® and Infinium® Assay for Methylation" published in 2010 and found at:
  • Illumina has developed a method to consistently designate CpG loci based on the actual or contextual sequence of each individual CpG locus.
  • Illumina® has developed a consistent and deterministic CpG loci database to ensure uniformity in the reporting of methylation data.
  • the Illumina® method takes advantage of sequences flanking a CpG locus to generate a unique CpG locus cluster ID. This number is based on sequence information only and is unaffected by genome version.
  • Illumina 's standardized nomenclature also parallels the TOP/BOT strand nomenclature (which indicates the strand orientation) commonly used for single nucleotide polymorphism (SNP) designation.
  • SNP single nucleotide polymorphism
  • the methylation of at least one, at least 2, at least 3, at least 5, at least 10 or at least 20 CpG sites listed in Table 2 that exist in one or more genes selected from target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif are assessed.
  • the methylation of at least one, at least 2, at least 3, at least 5, at least 10 or at least 20 CpG sites that are used in the Illumina® Infinium Human Methylation27 BeadChip kit and that are present in one or more genes selected from target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif are assessed.
  • the CpG sites in the promoters or regulatory regions of the genes of interest identified in Table 2 are typically unmethylated in samples from patients that are not at significant risk of developing cancer. On the contrary, the methylation of one or more CpG sites in the promoter or regulatory regions of these genes correlate with an increased risk of developing cancer. Thus, these subjects display hypermethylation.
  • Such aberrant hypermethylation can result in transcriptional silencing, for example by impeding the binding of transcriptional factors to the target gene or by recruitment of proteins such as methyl-CpG-binding domain proteins (MBDs). MBD proteins then recruit additional proteins to the locus, such as histone deacetylases and other chromatin remodeling proteins that can modify histones thereby forming compact, inactive chromatin.
  • MBD proteins methyl-CpG-binding domain proteins
  • the aberrant hypermethylation can lead to the silencing of genes that are normally required for the differentiation of stem or progenitor cells and can thus promote maintenance of a stem or progenitor cell state.
  • the methods of the invention involve an assessment of hypermethylation of DNA, wherein hypermethylation is predictive of a risk of developing cancer, for example breast cancer.
  • hypermethylation refers to the methylation of at least one, at least two or at least three CpG sites in the promoter or regulatory region of a gene of interest.
  • typically methylation of one or more CpG sites in the promoter or regulatory region of at least 1, at least 2, at least 3 or at least 5 genes selected from Table 2 that are target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif is predictive of a risk of developing breast cancer.
  • it may be a lack of methylation, i.e.
  • hypomethylation that is predictive of a risk of developing cancer. This is aberrant hypomethylation is less common than aberrant hypermethylation but is observed in some genes.
  • Methods of detecting DNA methylation are well known to those skilled in the art. For example, techniques including methylation specific polymerase chain reaction (PC ), use of antibodies to DNA methylation associated proteins, methylated DNA immunoprecipitation (MeDIP), or use of restriction enzymes specific to fully methylated or unmethylated sites may be used in the methods of the present invention.
  • PC methylation specific polymerase chain reaction
  • MeDIP methylated DNA immunoprecipitation
  • restriction enzymes specific to fully methylated or unmethylated sites may be used in the methods of the present invention.
  • kits for detecting DNA methylation are widely available and may also be used.
  • kits such as the Illumina® methylation assay (e.g. Illumina® Infinium Human Methylation27 BeadChip kit), which allow the simultaneous analysis of the methylation status of multiple CpG sites arranged on a microarray or chip, may be used in the methods of the invention.
  • the assessment of the methylation status of one or more genes of interest involves use of a microarray on which oligonucleotides comprising one or more CpG sites from a plurality of genes selected from Table 2are bound.
  • a plurality of oligonucleotides comprising one or more CpG sites from at least 3, at least 5, at least 7 or at least 10 genes selected from Table 2 are bound to the microarray.
  • a plurality of oligonucleotides comprising one or more CpG sites from at least 5, at least 10, at least 15 or at least 20, at least 30, at least 40 or at least 50 genes selected from the PCGT genes in Table 2 are bound to the microarray.
  • samples of genomic DNA isolated from a subject may be contacted with such microarrays in order to assess the DNA methylation status and thus to predict that subject's risk of developing cancer.
  • the risk of a subject developing cancer can be predicted.
  • the subject is a human subject, which is to say a female human subject in the case of breast cancer.
  • the methods of the invention may be used to predict the risk of developing any type of cancer, such as any type of sarcoma, carcinoma, lymphoma, leukaemia or blastoma.
  • Reference to cancer is intended to cover hyperproliferative disorders such as tumours and neoplasms.
  • the tumour or neoplasm is malignant
  • the cancer is breast cancer.
  • the risk of developing cancer for example breast cancer is predicted in advance of the onset of signs or clinical symptoms of cancer, for example up to 2 years, up to 5 years or up to 10 years, or at least 2, 3, 4 or 5 years in advance of the onset of signs or clinical symptoms of cancer.
  • the risk may be predicted in healthy subjects that have never had cancer, subjects that have had at least one benign tumour and subjects that have had cancer but at the time of assessment are showing no signs or clinical symptoms of the disease.
  • the methods of the invention may be used to predict the risk of recurrence of cancer as well as the risk of its occurrence for the first time.
  • the risk of developing breast cancer is predicted based on the DNA methylation status of one or more CpG sites from at least 2, or at least 5, 10 or 20 genes selected from Table 2 that are target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif. Most preferably, this risk is predicted based on the DNA methylation status of at least 2, or at least 5, 10 or 20 PCGTs. Combinations of the above types of genes may also be tested.
  • the methods of the invention may be used to predict the risk of developing sporadic cancer.
  • the methods of the invention can be used to predict the risk of onset of disease in hereditary cancer, i.e. in individuals already carrying a high- risk genetic factor.
  • the prediction of risk of a subject developing cancer may be based on presence or absence of one or more genetic risk factors such as gene variants or single nucleotide polymorphisms (SNPs) associated with a risk of developing cancer.
  • SNPs single nucleotide polymorphisms
  • Gene variants may include mutations in one or more oncogenes or tumor suppressor genes that are known to be associated with a predisposition to developing cancer. For example, in the case of predicting risk of developing breast cancer, an individual may be assessed for the presence of mutations in the BRCA1 and/or BRCA2 gene.
  • the prediction of risk of developing cancer may be based on the assessment of traditional risk factors of cancer.
  • Traditional risk factors of breast cancer may include, but are not limited to age, geographic location, previous incidence of breast cancer, pre-existing non-cancer disease, previous benign breast disease, breast density (e.g. on a mammogram) and reproductive history. Other factors such as diet, alcohol consumption, socioeconomic group and family history can also be considered.
  • a subject may be categorised as being at low, medium or high risk of developing cancer based for example on the degree of hypermethylation (or, less commonly, hypomethylation, or both hypermethylation and hypomethylation) amongst the genes assessed - for example number of CpG sites per gene promoter or regulatory region, and/or the number of genes that are hypermethylated (or hypomethylated, or both) - and the presence or absence of one or more genetic or traditional risk factors.
  • a subject at risk of developing cancer refers to a subject that is predisposed to developing a particular type of cancer, including subjects in remission that are predisposed to develop recurrence of cancer.
  • the hypermethylation of several genes selected from target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif, together with either the presence of a mutation in BRCAl 2 associated with a risk of developing breast cancer, or a previous history of cancer may indicate a high level risk of a subject developing breast cancer.
  • a subject showing no or a low degree of hypermethylation of the genes assessed and with a low risk based on genetic or traditional risk factors for breast cancer may indicate a low level risk of developing breast cancer.
  • the level of risk identified may indicate a low, medium or high level of risk for developing cancer in the next 2 years, in the next 5 years or in the next 10 years following the assessment.
  • the presence of one or more methylated CpG sites in at least 1 , at least 2 or at least 5 genes selected from Table 2 that are target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif may increase the subject's risk of developing cancer by age 90 by up to 2%, up to 5%, up to 10% or up to 20%.
  • the methods of the invention are used to predict the risk of the subject dying from said cancer.
  • the invention also provides a method for selecting a subject suitable for preventative treatment of cancer, for example breast cancer, comprising or essentially consisting of:
  • the invention can thus enable a screen amongst healthy subjects to identify those subjects at most risk of developing cancer. In the clinic, this can enable subjects suitable for preventative or prophylactic treatment to be selected based on the level of risk identified.
  • the subjects selected for preventative treatment show a medium or high risk of developing cancer.
  • an individual with medium risk may have a 20%, 30% or 40% risk of developing cancer by age 90.
  • An individual with a high risk may have a 50%, 60%, 70%, 80% or 90% risk of developing cancer by age 90.
  • Preventative measures include any treatment for cancer that can completely prevent incidence of cancer or partially prevent cancer, for example such that the occurrence of pathological cells, severity of disease and/or prognosis is better than would have occurred without such treatment.
  • Such preventative treatment for cancer may include surgical intervention, increased screening programs and/or administration of a pharmaceutical drug.
  • surgical intervention may include mastectomy.
  • the pharmaceutical drug may include a small molecule drug, or biological drug such as a nucleic acid molecule or antibody suitable for the preventative treatment of cancer.
  • a small molecule drug or biological drug such as a nucleic acid molecule or antibody suitable for the preventative treatment of cancer.
  • an antihormone such as tamoxifen, raloxifen, aromatase inhibitor, GnRH analoga or antiprogestin may be administered.
  • Drugs that inhibit targets involved in the onset or development of cancer may alternatively, or additionally be used.
  • small molecule inhibitors or antibodies against RANKL e.g. Denosumab
  • Increased screening programs may be used in order to detect onset of the cancer earlier in subjects identified as being at risk of developing the disease.
  • screening programs may include use of mammography, ultrasound or magnetic resonance imaging (MRI).
  • the serum samples in these Examples were drawn from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Having recruited 202,638 women between 2001-2005, this is one of the largest prospectively randomised clinical trials. The trial aims to assess the impact of screening on mortality from ovarian cancer in a population with low genetic ovarian and breast cancer risk. Up to February 2009, a total of 2,629 women developed breast cancer after they have been recruited into UKCTOCS. In a nested prospective case control design we identified 382 healthy postmenopausal women (aged 50-75 years).
  • Protein truncation test was used as a prescreening method for exon 11 and direct sequencing was used as a detection method for exons 2-10 and 12-24 (exons la and lb are non-coding exons and are not analyzed in standard protocols). All the mutations detected were confirmed by direct sequencing using at least two different primers on original and re-sampled DNA. Multiplex ligation-dependent probe amplification (MLPA) was used to detect large genomic rearrangement. Long-range PCR, isolation of certain alleles and direct sequencing were used to identify break-point of those rearrangements (Pohlreich et al 2005).
  • MLPA Multiplex ligation-dependent probe amplification
  • the DNA from 500 serum was extracted at Tepnel (www.tepnel.com), using Qiagen QiAamp Blood Mini Kit (51106). The overall average DNA
  • serum DNA represents a pool of DNA from various organs and tissues, and potentially may include DNA from preneoplastic cells. But if the serum has not been spun down within 1-2 hours after the blood was taken, the dominant component of serum DNA however is likely to be blood cell DNA.
  • the DNA from whole blood and breast tissues was extracted using a chloroform based extraction method from 400 ⁇ of blood and Qiagen DNeasy Blood & Tissue Kit (69504), respectively.
  • Methylation analysis was performed using the validated Illumina Infmium Human Methylation27 BeadChip.
  • the raw data has been deposited on GEO (http://www.ncbi.nlm.nih.gov/geo/) under accession number GSE26102.
  • Singular value decomposition has also proven to be an efficient method for identifying complex methylation patterns in disease.
  • SVD Singular value decomposition
  • the centering of the CpG profiles is important, as otherwise the top principal component would only capture the inherent bi-modality of the beta-value distribution, thus providing the wrong null distribution.
  • SVD analysis on the discovery set predicted 16 significant principal components, which were then correlated to the experimental factors, including plate, sentrix chip, bisulphite conversion (BSC) efficiency (as assessed using the built-in BSC efficiency controls), DNA concentration, and the centre and season in which the sample was collected, as well as age (data not shown). Most of the variation was associated with potentially confounding plate and chip effects, hence, we first tried to adjust for these. Batch/chip effects are often detected in large-scale microarray experiments.
  • each CpG methylation profile was adjusted for potential confounders using a linear model with the confounders as covariates.
  • the adjusted CpG methylation profiles were subsequently standardised in the discovery and validation sets, by setting its mean across samples to zero and its standard deviation across samples to 1. Denoting by Y the case-control status, and by B the adjusted and standardized methylation profiles, our model is
  • the ensemble ELNET classifier was constructed by using 100 distinct training/test set partitions within the discovery set to construct 100 distinct elastic net classifiers.
  • the ensemble risk score of an independent sample is then obtained by averaging the predicted risk scores of each of the 100 classifiers. This procedure was used to evaluate classification performance of the ensemble classifier in the discovery set.
  • GSEA Gene set enrichment analysis
  • GSEA gene set enrichment analysis
  • PCGTs Polycomb group targets
  • hESCs human embryonic stem cells
  • I gsetl u gsetl ⁇ which is a positive fraction less than 1.
  • ELNET a state of the art statistical framework designed to avoid overfitting in high- dimensional data, to construct a classifier from the full set of 27,578 CpGs.
  • We obtained a mean AUC 0. 1
  • Table 1 shows the distribution of cases and controls with associated odds ratios (OR), 95% confidence intervals, and P-values of significance (Fisher-test) in the three risk groups of the discovery and validation sets.
  • FIG. 2A Target genes of Nuclear inhibitor of protein phosphatase- 1 (NIPP1), which is a transcriptional repressor and contributes to the recruitment of the Polycomb Repressor Complex (PRC2), (2) A selected set of stem cell polycomb group target genes (PCGTs) previously reported to undergo widespread methylation in cancer tissue, (3) Target genes of MSXl, a developmental regulator involved in mammary development and breast cancer, (4) Genes with an AACTTT promoter motif, which are heavily enriched for NIPP1 (NIPP1), which is a transcriptional repressor and contributes to the recruitment of the Polycomb Repressor Complex (PRC2), (2) A selected set of stem cell polycomb group target genes (PCGTs) previously reported to undergo widespread methylation in cancer tissue, (3) Target genes of MSXl, a developmental regulator involved in mammary development and breast cancer, (4) Genes with an AACTTT promoter motif, which are heavily enriched for
  • Stem cell polycomb group target genes were also highly enriched among hypermethylated cancer-risk CpG sites (Figure 2A).
  • the degree of overlap between enriched gene sets was often insignificant (e.g NANOG targets and PCGTs), indicating that the enrichment of many gene sets were independent of each other ( Figure 2A).
  • these stem cell gene categories were not enriched among CpGs hypomethylated in cases, and in fact were often underenriched ( Figure 2B).
  • DNA methylation risk signature was not due to the presence of disseminated preneoplastic or tumour cells, but rather represents a genuinely predictive tool in currently healthy individuals.
  • Table 2 below shows top ranked 5482 cancer risk CpGs, all passing FDR ⁇ 0.3, derived using a multivariate linear regression framework in the discovery set (148 controls and 134 cases), as described in the Examples above.
  • Each gene is refered to as "Symbol”, and each category of gene i.e. PCGTs, target of NIPP1, MSX- 1 or NANOG or genes with an AACTTT promoter motif are referred to under the appropriate titled columns ("PCGTs”, "NIPP1-T”, “MSX1-T”, “NANOG-T” and “AACTT-T” respectively).
  • 162138041 0 .68932124 0 .57835821 0 0 0 0 0 cg20217872 NAV3 89795 2.71665 0.007037242 0.
  • 208393663 1.35250847 0.56701291 0 0 0 0 0 cg23414387 CYP4B1 1580 -2.24433 0.025652841 0. 208393663 0.73343429 0.56650867 0 0 0 0 0 cgl8502522 SCAMP2 10066 2.24433 0.025652906 0. 208393663 1.34303653 0.57230738 0 0 0 0 0 cg08413366 PPP3CB 5532 2.24379 0.025687706 0.
  • 210201904 1.38406676 0.56665994 0 0 0 0 0 cgl2216205 C6orflll 25957 -2.22877 0.026684465 0. 210201904 0.74037478 0.57195442 0 0 0 1 0 cg25560840 KIAA0427 9811 2.2287 0.026689177 0. 210201904 1.364818 0.56832392 0 0 0 0 0 cg03131527 BDH 622 -2.2282 0.026722542 0. 210201904 0.74050964 0.56887858 0 0 0 0 0 cg22226839 ATP2B4 493 2.22818 0.026724045 0.
  • 210201904 1.36151364 0.57235781 0 0 0 0 1 cg08647727 MGC50559 254013 2.22817 0.026724907 0. 210201904 1.35761919 0.5663574 0 0 0 0 0 cg21750602 PPP2R2D 55844 -2.22805 0.026732884 0. 210201904 0.73330703 0.57039129 0 0 0 0 0 0 0 0 0
  • TNFSF12- cg00031162 TNFSF13 407977 -2.21958 0.027310332 0.212803939 0.74173583 0.57392094 cg25299176 YWHAE 7531 2.21936 0.027325857 0.212803939 1.35306578 0.58138362 cgl4501253 FU36980 286032 2.21927 0.027331966 0.21280393939 1.34716265 0.57755143 cgl9432434 SIKE 80143 2.21926 0.027332451 0.212803939 1.35311514 0.5794171 cgl3877895 GKN1 56287 -2.21915 0.027339739 0.212803939 0.73271472 0.58153489 cg04739485 MLXIP 22877 -2.21897 0.027352105 0.212803939 0.73574399 0.57064341 cgl6125615 CAPS 828 -2.2
  • 216123659 0.73446206 0.57205526 0 0 0 0 0 cg00746130 BAT5 7920 2.19134 0.029314536 0. 216123659 1.37073559 0.57654296 0 0 0 0 cg22067472 CYB5-M 80777 2.19133 0.029315444 0. 216123659 1.36021091 0.56514724 0 0 0 1 0 cg22593486 OR10H1 26539 -2.19123 0.029322887 0. 216123659 0.73832364 0.57896329 0 0 0 0 0 cgl4679587 GLS2 27165 2.19116 0.029328191 0.
  • 222480274 1.33398984 0.56973578 0 0 0 0 cgl8750756 MGC29671 201305 2.15168 0.032343425 0. 222480274 1.32850707 0.56040742 0 0 0 0 0 eg 11147886 NFAT5 10725 2.15159 0.032350597 0. 222480274 1.33712513 0.56900464 0 0 0 1 1 cgl7029168 NKX2-2 4821 2.15155 0.032354078 0. 222480274 1.33901408 0.61476402 1 0 1 0 1 cg01166674 ABCB8 11194 2.15151 0.032357126 0.
  • 222480274 1.34122798 0.57906414 0 0 0 0 0 cg27159719 TMEM71 137835 2.15122 0.032380367 0. 222480274 1.35883799 0.58178701 0 0 0 0 0 cg00134787 MYH 1 4619 -2.15108 0.032391892 0. 222480274 0.74095361 0.55955022 0 0 0 0 1 eg 14964658 PEX19 5824 2.15105 0.032393609 0.
  • 222480274 1.34334303 0.57523195 0 0 0 0 0 cg03573747 ADIPOQ 9370 -2.15102 0.032395929 0. 222480274 0.73632293 0.57301331 0 0 0 0 cg26267561 OXT 5020 2.15094 0.032402578 0. 222480274 1.34783309 0.57548407 0 0 0 0 0 cgl3022129 PHYHD1 254295 -2.15073 0.032419336 0.
  • 222480274 0.73614591 0.56454215 0 0 0 0 0 cg01909921 GFI1B 8328 2.15067 0.032424559 0. 222480274 1.34057687 0.57649254 0 0 0 0 0 cg07579404 RAET1L 154064 2.15044 0.032442357 0. 222522554 1.33428022 0.58531666 0 0 0 0 0 cg08747889 PTK7 5754 2.14967 0.032504255 0. 222813928 1.34904711 0.57472771 0 0 0 0 0 cg02381948 MGMT 4255 -2.14948 0.03251922 0.
  • .047888762 0.249436918 1.30708393 0.58612344 cgl l373746 ALDH9A1 223 1.98773 0. .047890491 0.249436918 1.31179747 0.56756757 cgl2547930 WFDC6 140870 -1.98773 0. .047890942 0.249436918 0.76217342 0.56353368 cg25172835 PUNC 9543 -1.98767 0. .047897076 0.249436918 0.75899555 0.57467729 cg26062370 MGC18079 146395 1.98724 0.

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Abstract

A method for predicting the risk in a subject of developing cancer, the method comprising: a)assessing in a sample of genomic DNA from said subject the methylation status of one or more genes selected from a target gene of NIPP1, MSX1 or NANOG, a polycomb group target gene (PCGT) or a gene with an AACTTT promoter motif; and b)predicting the subject's risk of developing cancer based on said methylation status.

Description

METHOD FOR PREDICTING RISK OF DEVELOPING CANCER
Field of the Invention
The invention relates to predicting the risk in a subject of developing cancer, in particular breast cancer. The invention also relates to the selection of subjects suitable for prophylactic treatment of cancer.
Background to the Invention
Use of more accurate methods for predicting an individual's risk of developing cancer can lead to advances in cancer management and patient survival by enabling the selection of patients that would most benefit from preventative treatment and ultimately enhancing the potential for survival.
Breast cancer is the most common cancer affecting at least 1 in 10 women in the western world. Predicting the risk and offering preventive measures has been demonstrated to be an effective intervention in women with an inherited breast cancer predisposition. In particular, in screening programs clinicians currently use guidelines that recommend the identification of carriers of BRCAl and BRCA2 mutations, which confer very high risks of breast cancer and ovarian cancer. However, BRCAl/2 mutations only account for approximately 10% of breast cancers. About 90% of breast cancers are sporadic and only about 10% inherited. Predicting the likelihood of developing breast cancer is therefore particularly important for women who have no particular family history of the condition.
Many traditional risk factors have been defined for breast cancer, for example age, geographic location, previous breast cancer, previous benign breast disease and reproductive history. Other factors such as diet, alcohol consumption, socioeconomic group and family history can also be considered. While modification of personal habits, reproductive considerations, and behavior can reduce risk, the benefits are modest and certainly offer no guarantees.
Genetic risk factors have also been investigated. Single-nucleotide
polymorphisms (SNPs) have been shown to be associated with cancer in genome wide association studies but confer only small increases in risk. In particular, the inclusion of newly discovered genetic factors only modestly improves the performance of existing risk models for breast cancer. In risk models for predicting cancer, a receiver- operating-characteristic (ROC) curve analysis is often used, in which the area under the curve (AUC) is assessed. Each point on the ROC curve shows the effect of a rule for turning a risk estimate into a prediction of the development of cancer in an individual. The AUC measures how well the model discriminates between case subjects and control subjects. An ROC curve that corresponds to a random
classification of case subjects and control subjects is a straight line with an AUC of 50%. An ROC curve that corresponds to perfect classification has an AUC of 100%. Epidemiological models that also include risk associated SNPs for the prediction of breast cancer in an individual have been shown to yield a ROC AUC of only 62%, a modest 4% improvement over the AUC of epidemiological models.
Predicting the prospective risk of cancer, in particular breast cancer, is therefore still a very challenging problem.
Summary of the Invention
The present inventors have found that assessment of a healthy individual's DNA methylation profile up to several years in advance of any subsequent diagnosis of cancer has the potential to predict that individual's risk of developing cancer. In particular, the inventors have identified an aberrant DNA methylation profile in genes encoding developmental transcription factors required for the differentiation of stem or progenitor cells, as well as target genes of transcription factors that are involved in stem or progenitor cell differentiation, in individuals predisposed to cancer. Thus, aberrant DNA methylation profiles are seen in genes that are required for the differentiation of stem or progenitor cells. The genes in which aberrant methylation has been identified by the inventors include target genes of Nuclear Inhibitor of Protein Phosphatase- 1 (NIPP1), Msh homeobox 1 (MSX1) or NANOG, Polycomb- group target genes (PCGTs) and genes with an AACTTT promoter motif. Although DNA methylation profiles of patients who have already developed cancer are characterised by aberrant DNA methylation, the present inventors have analysed an individual's DNA methylation status several years in advance of any diagnosis of cancer. A statistical analysis of the DNA methylation status in samples from initially healthy individuals and later samples from the same individuals, has revealed that target genes of NIPPl, MSXl or NANOG, Polycomb-group target genes (PCGTs) and/or genes with an AACTTT promoter motif can show a methylation profile that indicates a predisposition to developing cancer, such as breast cancer. Such aberrant DNA methylation profiles can be seen in advance of any signs or clinical symptoms of cancer.
In addition, the present invention offers an advance indication of the risk of an individual dying from cancer, particularly breast cancer. This is the first time that a specific test performed on healthy individuals is not only indicative of the risk to develop cancer, but also the risk of whether an individual is more likely to die from the disease. These findings open up an entirely new window of opportunity for assessing the risk of a common cancer such as breast cancer: to date strategies to early detect breast cancer have been hampered by detection of abnormalities that would not become clinically relevant over a lifetime, i.e. are over-diagnosed. These over- diagnosed cancers cause huge anxiety, unnecessary treatment and are a major burden to the health system. Hence, a test which is able to indicate, up to five years in advance, the risk of developing a deadly cancer, is a significant and beneficial development. Accordingly, the present invention provides a method for predicting the risk in a subject of developing cancer, the method comprising:
a) assessing in a sample of genomic DNA from said subject the methylation status of one or more genes selected from a target gene of NIPPl, MSXl or NANOG, a polycomb group target gene (PCGT) or a gene with an AACTTT promoter motif; and; b) predicting the subject's risk of developing cancer based on said methylation status.
The invention further provides a method for selecting a subject suitable for preventative treatment of cancer, the method comprising:
a) predicting the subject's risk of developing cancer as described above; and
b) selecting a subject for preventative treatment of cancer based on the level of risk predicted Brief Description of the Figures
Figure 1 outlines the study design and identification/validation of DNA methylation breast cancer risk profile. (A) Flowchart depicting strategy used to derive and validate a serum DNA methylation based risk predictor of breast cancer. (B) Histogram of P-values derived in discovery set. (C) FDR estimation using q- value procedure: for each number of top ranked CpGs declared positive (x-axis) we plot the expected number of false positives (y-axis). (D) Mean ROC curve, AUC and 95%CI for the 100 elastic net (ELNET) classifiers trained in the discovery set. (E) Penalty parameter (log(lambda) x-axis) estimation using internal cross-validation procedure in the elastic net. y-axis denotes error as a function of penalty parameter. Number of CpGs in classifier at each parameter value given on top axis. (F) ROC curve, AUC and 95%CI of the ensemble ELNET classifier in the validation set. (G) ROC curve, AUC and 95%CI of an ELNET classifier trained on whole discovery set in the validation set. Dashed green line denotes the line of AUC=0.5.
Figure 2 shows a Gene Set Enrichment Analysis (GSEA) of breast cancer risk signature. (A) GSEA of genes significantly hypermethylated in prospective cases. Enriched gene categories are sorted in a network according to their P-values of enrichment (dark to light shading indicates decreasing levels of significance). Edges between gene categories reflect significant overlap in the corresponding gene sets (as measured by Jaccard coefficient). Dark shading to light shading indicate decreasing levels of gene overlap. Pujana BRCA1 network is specially highly ranked when considering samples from prospective cases well before diagnosis. (B) Heatmap of normalised methylation values (dark shading=relative high methylation, lighter shading=relative low methylation) in the discovery set and across the top 1000 cancer- risk CpGs. CpGs and samples have been clustered using hierarchical clustering and a Pearson correlation metric. The shaded bars denote the two main clusters (lighter bar on the left, darker bar on the right) and if sample is a case (black) or control (white). Distribution of cases/controls is given and associated P-value is that of a Fisher-test. Right panel shows the enrichment of stem-cell related gene sets among CpGs hypermethylated in cases relative to controls. Dashed line separates hypermethylated from hypomethylated CpGs.
Figure 3 show a comparison of DNA methylation signature in cases diagnosed early and late after sample collection. (A) Comparison of P-value histograms from the supervised multivariate regression analysis of methylation beta values against case control status, using 50 cases who were diagnosed early (<1.5 years since sample draw) (top left panel), and separately, using 50 cases who were diagnosed late (>2.5 years after sample draw). (B) Left panel plots the t-statistics from the top 500 risk CpGs as derived from a multivariate regression using early diagnosed cases vs controls (x-axis) against their corresponding t-statistics using cases who were diagnosed later (defined as in panel A) (y-axis). Right panel shows the same plot but selecting the top 500 risk CpGs using cases who were diagnosed later. Dark dots (light dots) denotes significant hyper (hypo) methylated in cases of the first set. The number of CpGs broken up according to their hypermethylated and hypomethylated pattern in early and late diagnosed cases is given, together with the associated Fisher-test P- value.
Figure 4 shows a breast cancer risk signature in non-neoplastic and cancerous breast and in peripheral blood cells from cancer-free BRCAl mutation carriers. Boxplots show the average methylation levels of top cancer risk CpGs, hypermethylated (hyperM) and hypomethylated (hypoM) in prospective U CTOCS cases. The number of samples/data points in each boxplot are given on the bottom axis. P-values are either from a linear regression (A) or from a Wilcoxon rank sum test (B). Tables give the distribution of the top hypermethylated and hypomethylated cancer risk CpGs according to whether hypermethylated or hypomethylated in breast cancer tissue or the blood samples from BRCAl mutation carriers. P-value is from a Fisher- test. (A) Non-neoplastic breast tissue (N) (n=23) and E positive invasive breast cancer samples (n=l 12) of different grade (Gl, G2, G3). (B) Peripheral blood DNA samples of healthy BRCAl mutation carriers (mt-H) and age-matched healthy BRCAl wild type controls (wt-H).
Figure 5 is an enhanced version of Figure 2B, denoting information gained from at least 6 years of follow up since the sample was provided. Of the 180 women (134 in discovery and 48 in validation set) who developed breast cancer, 15 women died of breast cancer within six years after they provided the sample (indicated with additional vertical bars at the top of the discovery set).
Figure 6 shows a Kaplan Meier curve and likelihood ratio test pyalue derived from the data of Figure 5 : women who demonstrated a stem cell
hypermethylation profile had a higher chance of developing breast cancer 0.5 - 5 years after their sample was taken, but also demonstrated a substantially higher risk of dying from their breast cancer within 6 years.
Detailed Description of the Invention
Summary
The present invention relates to the assessment of a subject's DNA methylation status in target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) and/or genes with an AACTTT promoter motif and the use of this methylation status to predict the risk of developing cancer in that subject. Preferably, said target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) and/or genes with an AACTTT promoter motif are required for the differentiation of stem or progenitor cells. Genes of interest Typically, in the methods of the invention said one or more genes selected from target genes of NIPP1, MSXl or NANOG, polycomb group target genes (PCGT) and/or genes with an AACTTT promoter motif are involved in stem cell biology and/or the differentiation of stem cells. In particular, these genes may encode developmental transcription factors needed for differentiation of stem cells, and/or are target genes of transcription factors that are involved in stem cell biology. Most preferably, said one or more genes are required for the differentiation of stem or progenitor cells, for example stem or progenitor cells in breast tissue. As such the genes of interest may be involved in the loss of pluripotency and proliferative potential and the development of a more specialized cell type.
NIPP1, Polycomb-group proteins, MSXl and NANOG all suppress differentiation by occupying and suppressing certain sets of genes. NIPP1 is a transcriptional repressor and contributes to the recruitment of the Polycomb Repressor Complex (PRC2). PCGTs are genes that are targeted by polycomb-group proteins such as PRC1, PRC2 and PhoRC. Such Polycomb-group proteins act in a multiprotein complex to repress gene expression from the target gene, such as a target gene involved in differentiation of a stem cell. MSXl is a transcriptional repressor involved in mammary development and breast cancer. NANOG is a transcriptional factor known to maintain pluripotency of stem cells.
Thus in one embodiment of the invention, the genes of interest are genes required for the differentiation of stem or progenitor cells, the expression of which is regulated by either NIPP1, Polycomb-group proteins, MSXl and/or NANOG. Most preferably, the genes of interest are genes required for the differentiation of stem or progenitor cells, the expression of which is regulated by Polycomb-group proteins.
Genes with an AACTTT promoter motif, are heavily enriched for
developmental transcription factors. Thus, in another embodiment of the invention, the genes of interest are genes with an AACTTT promoter motif that encode transcription factors required for the differentiation of stem or progenitor cells, for example stem or progenitor cells in breast tissue. In one embodiment of the invention, said one or more genes of interest are required for the differentiation of stem or progenitor cells and are selected from genes in Table 2 that are target genes of NIPP1, MSX1, NANOG or polycomb group proteins (PCGTs) or genes with an AACTTT promoter motif. Most preferably, said one or more genes selected from Table 2 are required for the differentiation of stem or progenitor cells in breast tissue.
Typically, the DNA methylation status is assessed in 1 or more, 3 or more, 5 or more, or 10 or genes selected from Table 2 that are target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif. Preferably, the DNA methylation status of 1 or more, 3 or more or 5 or more PCGTs selected from Table 2 are assessed.
Sample of genomic DNA
In the methods of the invention, the sample of genomic DNA may be obtained from any available source of tissue or cells isolated from the subject. This may include but is not limited to solid tissue samples, liquid tissue samples, biological fluids, aspirates, cells and cell fragments.
In particular, such samples may be isolated from blood, serum, plasma, peripheral blood cells, cerebrospinal fluid, urine, fine needle aspirate, saliva, sputum, breast or other hormone dependent tissue, breast milk, bone marrow, skin, epithelia (including buccal, cervical or vaginal epithelia) or other tissue derived from the ectoderm. In some embodiments, the sample of genomic DNA comprises cells from a tissue that is involved in the type of cancer concerned. Most preferably, the sample of genomic DNA is isolated from breast or other hormone dependent tissue, serum, peripheral blood cells, buccal epithelia, cervical epithelia or vaginal epithelia.
Methods for sample isolation and for the subsequent extraction and isolation of DNA from such cell or tissue samples in preparation for assessing DNA methylation, are well known to those skilled in the art. Any suitable methods may be used. DNA methylation status Typically, an assessment of DNA methylation status involves analysing the presence or absence of methyl groups in DNA, for example methyl groups on the 5 position of one or more cytosine nucleotides. Preferably, the methylation status of one or more cytosine nucleotides present as a CpG dinucleotide (where C stands for Cytosine, G for Guanine and p for the phosphate group linking the two) is assessed. Such "CpG sites" may occur in the promoter or regulatory regions of a gene of interest. Most typically, the methylation status of CpGs clustered in CpG islands is assessed, for example CpG islands present in the regulatory regions of genes, especially in their promoter regions.
A promoter is a nucleotide sequence, which initiates and regulates transcription of a polypeptide-encoding polynucleotide. As well as promoters the genes used in the methods of the present invention may comprise further regulatory regions comprising one or more cytosine residues. Typically, such further regulatory regions provide additional levels of transcription control, for example ensuring cell specific gene expression or expression under certain conditions. Further regulatory regions, such as enhancer elements, may be downstream or upstream of the gene of interest or of the promoter.
Thus, in the methods of the invention, the methylation of at least one, at least 2, at least 3, at least 5, at least 10 or at least 20 CpG sites is assessed in the regulatory region of one or more genes selected from target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif. Preferably, said target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif are selected from Table 2. In general, it will be sufficient to assess one CpG per gene, because the methylation status of one CpG in a CpG island tends to be representative of that of other CpGs in the island. However, multiple CpGs per gene can also be assessed.
The methods of the invention may involve an assessment of the methylation of CpG sites in the genes of interest identified in Table 2. Table 2 provides CpG loci identifiers under the column entitled "CpG". These CpG loci identifiers refer to individual CpG sites used in the commercially available Illumina® Infinium Human Methylation27 BeadChip kit. The identity of each CpG site represented by each CpG loci identifier is publicly available from the Illumina, Inc website under reference to the CpG sites used in the Infmium Human Methylation27 BeadChip kit. For example, the identity of each CpG site can be found under the link to
HumanMethylation27 270596 v.1.2.bpm (deposited 6 February 2008) at the following website:
ftp://f .iUuminaxom/Methyk
Further information regarding CpG loci identification used in Illumina, Inc products is found in the technical note entitled "Technical Note: Epigentics. CpG Loci Identification. A guide to Illumina 's method for unambiguous CpG loci identification and tracking for the Golden Gate® and Infinium® Assay for Methylation" published in 2010 and found at:
http://wmyillumina.CQm
on.pdf.
As explained in this technical note, rather than using the evolving public databases to provide accurate CpG loci identifiers and strand orientation, Illumina has developed a method to consistently designate CpG loci based on the actual or contextual sequence of each individual CpG locus. To unambiguously refer to CpG loci in any species, Illumina® has developed a consistent and deterministic CpG loci database to ensure uniformity in the reporting of methylation data. The Illumina® method takes advantage of sequences flanking a CpG locus to generate a unique CpG locus cluster ID. This number is based on sequence information only and is unaffected by genome version. Illumina 's standardized nomenclature also parallels the TOP/BOT strand nomenclature (which indicates the strand orientation) commonly used for single nucleotide polymorphism (SNP) designation.
Preferably, the methylation of at least one, at least 2, at least 3, at least 5, at least 10 or at least 20 CpG sites listed in Table 2 that exist in one or more genes selected from target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif are assessed. Typically the methylation of at least one, at least 2, at least 3, at least 5, at least 10 or at least 20 CpG sites that are used in the Illumina® Infinium Human Methylation27 BeadChip kit and that are present in one or more genes selected from target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif are assessed.
The CpG sites in the promoters or regulatory regions of the genes of interest identified in Table 2 are typically unmethylated in samples from patients that are not at significant risk of developing cancer. On the contrary, the methylation of one or more CpG sites in the promoter or regulatory regions of these genes correlate with an increased risk of developing cancer. Thus, these subjects display hypermethylation.
Such aberrant hypermethylation can result in transcriptional silencing, for example by impeding the binding of transcriptional factors to the target gene or by recruitment of proteins such as methyl-CpG-binding domain proteins (MBDs). MBD proteins then recruit additional proteins to the locus, such as histone deacetylases and other chromatin remodeling proteins that can modify histones thereby forming compact, inactive chromatin. As the genes in Table 2 selected from target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif are required for the differentiation of stem or progenitor cells, the aberrant hypermethylation can lead to the silencing of genes that are normally required for the differentiation of stem or progenitor cells and can thus promote maintenance of a stem or progenitor cell state.
Thus in one embodiment, the methods of the invention involve an assessment of hypermethylation of DNA, wherein hypermethylation is predictive of a risk of developing cancer, for example breast cancer. Preferably, hypermethylation refers to the methylation of at least one, at least two or at least three CpG sites in the promoter or regulatory region of a gene of interest. Thus, typically methylation of one or more CpG sites in the promoter or regulatory region of at least 1, at least 2, at least 3 or at least 5 genes selected from Table 2 that are target genes of NIPPl, MSXl or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif, is predictive of a risk of developing breast cancer. However, in certain embodiments, it may be a lack of methylation, i.e.
hypomethylation, that is predictive of a risk of developing cancer. This is aberrant hypomethylation is less common than aberrant hypermethylation but is observed in some genes.
Methods of detecting DNA methylation are well known to those skilled in the art. For example, techniques including methylation specific polymerase chain reaction (PC ), use of antibodies to DNA methylation associated proteins, methylated DNA immunoprecipitation (MeDIP), or use of restriction enzymes specific to fully methylated or unmethylated sites may be used in the methods of the present invention.
In addition, commercial kits for detecting DNA methylation are widely available and may also be used. For example, commercially available kits such as the Illumina® methylation assay (e.g. Illumina® Infinium Human Methylation27 BeadChip kit), which allow the simultaneous analysis of the methylation status of multiple CpG sites arranged on a microarray or chip, may be used in the methods of the invention.
In one embodiment, the assessment of the methylation status of one or more genes of interest involves use of a microarray on which oligonucleotides comprising one or more CpG sites from a plurality of genes selected from Table 2are bound. Typically, a plurality of oligonucleotides comprising one or more CpG sites from at least 3, at least 5, at least 7 or at least 10 genes selected from Table 2 are bound to the microarray. Most typically, a plurality of oligonucleotides comprising one or more CpG sites from at least 5, at least 10, at least 15 or at least 20, at least 30, at least 40 or at least 50 genes selected from the PCGT genes in Table 2 are bound to the microarray.
In accordance with the methods of the invention, samples of genomic DNA isolated from a subject may be contacted with such microarrays in order to assess the DNA methylation status and thus to predict that subject's risk of developing cancer.
Predicting risk of developing cancer in a subject Based on an assessment of the DNA methylation status of samples according to the methods of the invention, the risk of a subject developing cancer can be predicted. Preferably, the subject is a human subject, which is to say a female human subject in the case of breast cancer.
The methods of the invention may be used to predict the risk of developing any type of cancer, such as any type of sarcoma, carcinoma, lymphoma, leukaemia or blastoma. Reference to cancer is intended to cover hyperproliferative disorders such as tumours and neoplasms. Typically, the tumour or neoplasm is malignant
(undergoing invasion or metastasis). In a preferred embodiment, the cancer is breast cancer.
Typically, the risk of developing cancer, for example breast cancer is predicted in advance of the onset of signs or clinical symptoms of cancer, for example up to 2 years, up to 5 years or up to 10 years, or at least 2, 3, 4 or 5 years in advance of the onset of signs or clinical symptoms of cancer. The risk may be predicted in healthy subjects that have never had cancer, subjects that have had at least one benign tumour and subjects that have had cancer but at the time of assessment are showing no signs or clinical symptoms of the disease. Thus, the methods of the invention may be used to predict the risk of recurrence of cancer as well as the risk of its occurrence for the first time.
Preferably, the risk of developing breast cancer is predicted based on the DNA methylation status of one or more CpG sites from at least 2, or at least 5, 10 or 20 genes selected from Table 2 that are target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif. Most preferably, this risk is predicted based on the DNA methylation status of at least 2, or at least 5, 10 or 20 PCGTs. Combinations of the above types of genes may also be tested.
The methods of the invention may be used to predict the risk of developing sporadic cancer. Alternatively, the methods of the invention can be used to predict the risk of onset of disease in hereditary cancer, i.e. in individuals already carrying a high- risk genetic factor. As well as an assessment of DNA methylation status, the prediction of risk of a subject developing cancer may be based on presence or absence of one or more genetic risk factors such as gene variants or single nucleotide polymorphisms (SNPs) associated with a risk of developing cancer.
Gene variants may include mutations in one or more oncogenes or tumor suppressor genes that are known to be associated with a predisposition to developing cancer. For example, in the case of predicting risk of developing breast cancer, an individual may be assessed for the presence of mutations in the BRCA1 and/or BRCA2 gene.
Alternatively or in addition to the use of SNPs alongside the methods of the invention, the prediction of risk of developing cancer may be based on the assessment of traditional risk factors of cancer. Traditional risk factors of breast cancer may include, but are not limited to age, geographic location, previous incidence of breast cancer, pre-existing non-cancer disease, previous benign breast disease, breast density (e.g. on a mammogram) and reproductive history. Other factors such as diet, alcohol consumption, socioeconomic group and family history can also be considered.
In the light of a subject's DNA methylation status together with the presence or absence of one or more genetic risk factors and/or the presence of one or more traditional risk factors, a prediction of the risk of the subject developing cancer can be made.
A subject may be categorised as being at low, medium or high risk of developing cancer based for example on the degree of hypermethylation (or, less commonly, hypomethylation, or both hypermethylation and hypomethylation) amongst the genes assessed - for example number of CpG sites per gene promoter or regulatory region, and/or the number of genes that are hypermethylated (or hypomethylated, or both) - and the presence or absence of one or more genetic or traditional risk factors. A subject at risk of developing cancer refers to a subject that is predisposed to developing a particular type of cancer, including subjects in remission that are predisposed to develop recurrence of cancer. For instance, in a subject showing no signs or clinical symptoms of the disease, the hypermethylation of several genes selected from target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif, together with either the presence of a mutation in BRCAl 2 associated with a risk of developing breast cancer, or a previous history of cancer, may indicate a high level risk of a subject developing breast cancer. A subject showing no or a low degree of hypermethylation of the genes assessed and with a low risk based on genetic or traditional risk factors for breast cancer, may indicate a low level risk of developing breast cancer.
In one embodiment, the level of risk identified may indicate a low, medium or high level of risk for developing cancer in the next 2 years, in the next 5 years or in the next 10 years following the assessment. The presence of one or more methylated CpG sites in at least 1 , at least 2 or at least 5 genes selected from Table 2 that are target genes of NIPP1, MSX1 or NANOG, polycomb group target genes (PCGT) or genes with an AACTTT promoter motif may increase the subject's risk of developing cancer by age 90 by up to 2%, up to 5%, up to 10% or up to 20%.
In preferred embodiments, the methods of the invention are used to predict the risk of the subject dying from said cancer.
Selecting patients for preventative treatment
The invention also provides a method for selecting a subject suitable for preventative treatment of cancer, for example breast cancer, comprising or essentially consisting of:
a) predicting the subject's risk of developing cancer according to the methods described herein; and
b) selecting a subject for preventative treatment of cancer based on the level of risk predicted.
The invention can thus enable a screen amongst healthy subjects to identify those subjects at most risk of developing cancer. In the clinic, this can enable subjects suitable for preventative or prophylactic treatment to be selected based on the level of risk identified. Thus, in one embodiment, the subjects selected for preventative treatment show a medium or high risk of developing cancer. For example, an individual with medium risk may have a 20%, 30% or 40% risk of developing cancer by age 90. An individual with a high risk may have a 50%, 60%, 70%, 80% or 90% risk of developing cancer by age 90.
Preventative measures include any treatment for cancer that can completely prevent incidence of cancer or partially prevent cancer, for example such that the occurrence of pathological cells, severity of disease and/or prognosis is better than would have occurred without such treatment.
Such preventative treatment for cancer may include surgical intervention, increased screening programs and/or administration of a pharmaceutical drug.
In the case of breast cancer, surgical intervention may include mastectomy.
The pharmaceutical drug may include a small molecule drug, or biological drug such as a nucleic acid molecule or antibody suitable for the preventative treatment of cancer. For example, in the case of breast cancer an antihormone such as tamoxifen, raloxifen, aromatase inhibitor, GnRH analoga or antiprogestin may be administered. Drugs that inhibit targets involved in the onset or development of cancer may alternatively, or additionally be used. For example small molecule inhibitors or antibodies against RANKL (e.g. Denosumab) can be used as preventative treatment for breast cancer.
Increased screening programs may be used in order to detect onset of the cancer earlier in subjects identified as being at risk of developing the disease. For example, in the case of breast cancer, screening programs may include use of mammography, ultrasound or magnetic resonance imaging (MRI).
The following Examples illustrate the invention. In these Examples the following general experimental techniques were employed:
Examples UKCTOCS serum DNA samples
The serum samples in these Examples were drawn from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Having recruited 202,638 women between 2001-2005, this is one of the largest prospectively randomised clinical trials. The trial aims to assess the impact of screening on mortality from ovarian cancer in a population with low genetic ovarian and breast cancer risk. Up to February 2009, a total of 2,629 women developed breast cancer after they have been recruited into UKCTOCS. In a nested prospective case control design we identified 382 healthy postmenopausal women (aged 50-75 years). Of these women 182 (mean age 62.26) were cases as they developed ER-positive invasive breast cancer after their recruitment into the trial, were not on HRT treatment, and had donated a serum sample between 6 months and 5 years prior to diagnosis. The remaining 200 age-matched women (mean age 61.87) served as controls as they had neither previous history of breast cancer nor subsequent development of breast cancers by the last follow-up and were also not on HRT.
Non-neoplastic breast and breast cancer tissue samples
We analyzed 23 non-neoplastic breast tissue (mean age 47.61 ; 12
fibroadenoma, 6 mastopathic and 5 normal breast samples) and 112 estrogen receptor (ER) positive breast cancer samples with different grade (mean age 60.77) collected between February 1989 and August 2004.
Blood samples from BRCA1 mutation carriers and wild type controls
Whole blood samples were drawn from 15 healthy BRCA1 mutation carriers (mean age 57.13) and 15 age-matched healthy females without a BRCA1 mutation (mean age 56.8, Wilcoxon test p-value=0.66). An additional independent set of blood samples were drawn from 7 healthy BRCA1 mutation carriers (mean age 30.43) and 42 healthy females without a BRCA1 mutation (mean age 43.57, Wilcoxon test p- value=0.016). For BRCA1 mutation testing in DNA from whole blood, both BRCA1 mutation carriers and controls were tested for the presence of germ- line BRCA1 mutation, including large genomic rearrangements. Protein truncation test (PTT) was used as a prescreening method for exon 11 and direct sequencing was used as a detection method for exons 2-10 and 12-24 (exons la and lb are non-coding exons and are not analyzed in standard protocols). All the mutations detected were confirmed by direct sequencing using at least two different primers on original and re-sampled DNA. Multiplex ligation-dependent probe amplification (MLPA) was used to detect large genomic rearrangement. Long-range PCR, isolation of certain alleles and direct sequencing were used to identify break-point of those rearrangements (Pohlreich et al 2005).
DNA methylation analysis
The DNA from 500 serum was extracted at Tepnel (www.tepnel.com), using Qiagen QiAamp Blood Mini Kit (51106). The overall average DNA
concentration in all samples was 5.82 ng/μΐ, with the controls had a mean
concentration of 5.59 ng/μΐ, whereas prospective cases had 6.07 ng/μΐ.
In principle, serum DNA represents a pool of DNA from various organs and tissues, and potentially may include DNA from preneoplastic cells. But if the serum has not been spun down within 1-2 hours after the blood was taken, the dominant component of serum DNA however is likely to be blood cell DNA. To test this, we compared DNA methylation profiles, all obtained using Illumina's 27k Methylation beadchip, across various normal tissues, including serum DNA from our 282 samples (discovery set), whole blood samples from an independent set of 148 postmenopausal healthy women [Teschendorff et al Genome Res (2010) Apr;20(4):440-6], whole blood samples from another independent set of 94 pre and postmenopausal women with type- 1 diabetes [Teschendorff et al Genome Res (2010) Apr;20(4):440-6], 30 normal cervical smears [Teschendorff et al Genome Res (2010) Apr;20(4):440-6], 23 normal endometrial samples, and 23 non-neoplastic breast tissue samples. To overcome unwanted inter- study variability and to allow objective comparison of β- value methylation profiles across studies, we assigned methylation values to three states: unmethylated (0) if β<0.3, hemimethylated (1) if 0.3<β<0.7, and methylated (2) if β>0.7. We verified that these thresholds were sensible choices for calling unmethylated (0) and methylated (2) loci given that the corresponding peaks were located in all studies at less than 0.3 or more than 0.7 in the beta-scale. Nevertheless, to ensure that differences in methylation between samples from different studies were genuine and not caused by study-specific biases, we treated the hemimethylated state as a buffer zone, only counting CpGs as differentially methylated between two samples, if the corresponding β-values were less than 0.3 in one sample but larger than 0.7 in the other, or vice versa if greater than 0.7 in one sample and less than 0.3 in the other. This definition of a differentially methylated CpG naturally leads to a distance metric which counts the number of CpGs with an absolute difference in methylation state of 2 (i.e 0-2, or 2-0). Thus, for any given pair of tissue types we computed the average distance (i.e average number of differentially methylated CpGs) between the samples in one tissue type and the samples of the other. This analysis showed that average serum DNA methylation profiles were much more similar to whole blood DNAm profiles, than to those of epithelial tissues (cervix, endometrium, breast) (data not shown). We can thus conclude that most of the DNA in our serum samples is likely to be blood cell DNA.
The DNA from whole blood and breast tissues was extracted using a chloroform based extraction method from 400μί of blood and Qiagen DNeasy Blood & Tissue Kit (69504), respectively.
All DNA samples were bisulphite modified using the EZ DNA Methylation Kit D5008 (Zymo Research, Orange, CA, USA) according to the manufacturer's instructions.
Methylation analysis was performed using the validated Illumina Infmium Human Methylation27 BeadChip. The methylation status of a specifc CpG site was calculated from the intensity of the methylated (M) and unmethylated (U) alleles, as the ratio of fluorescent signals p=Max(M,0)/[Max(M,0)+Max(U,0)+100]. On this scale, 0<β<1, with β values close to 1 (0) indicating methylation (no methylation). Quality control procedures were also performed. The raw data has been deposited on GEO (http://www.ncbi.nlm.nih.gov/geo/) under accession number GSE26102.
Statistical analysis
Diagnostic Singular Value Decomposition (SVD) analysis
SVD and randomisations were used to determine the number and nature of the largest components of variation. Beadchip effects were adjusted for using a Bayesian algorithm.
Singular value decomposition (SVD) has also proven to be an efficient method for identifying complex methylation patterns in disease. We applied SVD to the centred methylation β-value data (i.e the average methylation value of each CpG across samples was set to zero) to determine the nature of the largest components of variation and hence to assess the variations caused by experimental factors (e.g.
variable bisulfite conversion efficiency, plate and chip effects etc.). Before performing the SVD analyses, missing β- value data were imputed using the k-nearest neighbours procedure [Leek and Storey 2008]. The number of missing values was less than 0.1% of the data and were caused by probes with inadequate number of good quality bead- level replicates, for which no β-values were reported. Significance of singular values/principal components was evaluated by randomly redistributing the centred data values (i.e within each sample, CpG values were randomly permuted) and comparing the observed singular values to the corresponding values obtained from the permuted data matrix. The centering of the CpG profiles is important, as otherwise the top principal component would only capture the inherent bi-modality of the beta-value distribution, thus providing the wrong null distribution. SVD analysis on the discovery set predicted 16 significant principal components, which were then correlated to the experimental factors, including plate, sentrix chip, bisulphite conversion (BSC) efficiency (as assessed using the built-in BSC efficiency controls), DNA concentration, and the centre and season in which the sample was collected, as well as age (data not shown). Most of the variation was associated with potentially confounding plate and chip effects, hence, we first tried to adjust for these. Batch/chip effects are often detected in large-scale microarray experiments. In this study, we applied the "ComBat" method [Johnson and Li Biostatistics (2007); 8.1 : 1 18-27] under a parametric empirical Bayes framework to correct both the discovery and validation sets for chip effects. The "ComBat" method is robust to outliers and allows for adjustment in the case where sample sizes per chip are small. To evaluate "Combat", we performed the same diagnostic SVD analysis on the Combat-adjusted-data from the discovery set. This showed that the number of significant principal components that correlated with experimental factors was reduced from 16 to 6, and moreover "Combat" efficiently removed the chip effects (data not shown). "Combat" was also applied to the 207 samples of the second set and over all 27,578 CpGs, to correct for chip effects (data not shown).
Supervised analysis
We used adjusted t-statistics to identify CpGs with β-value methylation profiles associated with disease status (i.e. future cancer or healthy), where adjustment was made for age and experimental factors (plate, DNA concentration, season and centre). To correct for multiple testing, we estimated the false discovery rate (FDR) using both an analytical procedure (q- values), and a permutation approach that preserves the potential correlations between CpGs.
Classification analysis
The aim was to determine if DNA methylation profiles in serum DNA could be used to predict breast cancer risk. We chose an elastic net (ELNET) classification framework, which has been shown to work effectively and to avoid overfltting in high- dimensional data sets. First of all, each CpG methylation profile was adjusted for potential confounders using a linear model with the confounders as covariates. The adjusted CpG methylation profiles were subsequently standardised in the discovery and validation sets, by setting its mean across samples to zero and its standard deviation across samples to 1. Denoting by Y the case-control status, and by B the adjusted and standardized methylation profiles, our model is
E[Y I B] = η0 + ΒΓη where η denotes the regression parameters to be estimated. To estimate the regression coefficients, we used the elastic net algorithm as implemented in the the glmnet R -package. For an independent test sample t with adjusted and standardized methylation profile j¾ , its risk score is then computed as Rt = ^ J?CA,C c=l where the sum can be done over all CpGs since those that do not contribute to the classifier have zero regression coefficients. The risk scores for an independent test set can then be correlated to disease outcome to obtain an AUC value.
We used two complementary strategies designed to test the robustness of the results. In the first strategy, we constructed an ensemble ELNET classifier in the discovery set and then tested this classifier in the validation set. The ensemble ELNET classifier was constructed by using 100 distinct training/test set partitions within the discovery set to construct 100 distinct elastic net classifiers. The ensemble risk score of an independent sample is then obtained by averaging the predicted risk scores of each of the 100 classifiers. This procedure was used to evaluate classification performance of the ensemble classifier in the discovery set.
In the second approach, we applied the elastic net classification on the top 5482 ranked CpGs (FDR<0.3) derived from the whole discovery set and selected the optimal features using an internal 10-fold cross-validation as implemented in the glmnet package. This classifier was then tested in the validation set by computing the predicted risk scores and the AUC.
Gene set enrichment analysis (GSEA)
In order to determine if cancer risk CpGs were enriched for gene ontologies, molecular pathways, chromosomal locations, or targets of regulatory motifs and miRNAs, we applied gene set enrichment analysis (GSEA) to an expanded version of the Molecular Signatures Database (MSigDB), representing a total collection of 6811 gene sets [Mootha et al (2003) Nat Genet; 34, 267-73 and Subramanian et al (2005) PNAS 102, 15545-50]. One important set of genes which were included in the database were Polycomb group targets (PCGTs) for which we defined two sets by single occupancy of any one of SUZ12, EED, and H3K27me3 in human embryonic stem cells (hESCs) and by triple occupancy of all three [Lee et al (2006) Cell Apr 21;125(2):301-13]. We focused on the subset of 6266 gene sets in MSigDB that had over 60% of their genes represented on the Illumina Infinium Methylation array. We applied GSEA to the top 5482 ranked hyper and hypomethylated CpGs derived from the discovery set, using a sliding threshold Fisher-test analysis. Briefly, we picked 20 equally distant centiles in the range 1% to -20% (5482/27578) and performed a Fisher- test of enrichment at each of these centiles on each gene set in MSigDB. FDR correction was done using the Benjamini-Hochberg procedure. For each gene set, the centile at which the best P-value was obtained, was recorded and gene sets were then ranked according to this best P-value. This sliding threshold analysis allows for a more unbiased estimation of enriched gene sets irrespective of gene set size. Finally, we selected from the top 00 enriched gene sets those with an FDR<0.1.
GSEA network
Differently annotated gene sets may share a significant overlap, which may thus lead to enrichments which are not independent of each other. To address this we constructed a dependency network of the selected enriched gene sets, with each node representing an enriched gene set and an edge in the network representing a statistically significant dependency between two enriched gene sets. To compute the dependency between two gene sets we use the Jaccard coefficient, defined as the ratio mi ,i ,Ο Λ I gsetl n gsetl \
JC(gsetl, gsetl) = — < 1
I gsetl u gsetl \ which is a positive fraction less than 1. To derive a null distribution, we randomly picked 10,000 pairs of gene sets from the MSigDB database (>6000 gene sets) and computed their Jaccard coefficients. We then took the 99.5% quantile of this distribution of null Jaccard coefficients, which corresponded to a value of JC-0.05. We used this threshold to assign edges representing dependencies, so that two gene sets with a JC larger than 0.05 were assigned an edge. This yielded GSEA networks with approximately 10% of the maximum possible number of edges. Significant dependencies could then be drawn as edges with the strength of the JC represented by different tones of grey.
Example 1
In order to address if CpG methylation is able to predict the risk of developing breast cancer, we analyzed 27,578 CpGs in DNA extracted from the serum of 382 healthy postmenopausal women in a nested case control design within the UKCTOCS trial encompassing serum DNA samples from over 200,000 women. Within the nested study, a total of 182 women developed an estrogen receptor positive (ER+) breast cancer 0.5 to 5 years after they had provided their serum sample. After a stringent quality control analysis we split the samples into a discovery set (134 cases and 148 controls) and a validation set (48 cases and 52 controls) (Figure 1A).
We used the discovery set to identify risk associated CpGs and to construct a risk predictor, which would then be tested in the validation set (Figure 1 A). We used a multivariate regression model that included other potential confounders to rank CpGs according to the significance of the association between their DNA methylation profile and case/control status. The histogram of P-values and the corresponding estimated false discovery rate (FDR) values indicated a remarkably strong association between DNA methylation and case control status (Figures 1B-C). Among the top 100 ranked CpG sites, we estimated an average of only 10 false positives. The analytical and empirical FDR estimates were also in strong agreement. Using a relaxed threshold of FDR<0.3 we observed a total of 5482 cancer-risk CpGs, of which 3395 (62%) were hypermethylated (hyperM) and 2087 (38%) were hypomethylated (hypoM) in women who subsequently developed breast cancer (Figure 1A), representing a highly significant skew towards hypermethylated CpGs (Binomial test P < 2 x 10~16 ). Example 2
Next, we investigated if the risk of developing breast cancer could be predicted in an independent prospectively collected sample set. We used the elastic net
(ELNET), a state of the art statistical framework designed to avoid overfitting in high- dimensional data, to construct a classifier from the full set of 27,578 CpGs. We used two complementary strategies to build an ELNET classifier, which would also allow us to test the robustness of the predictions. In the first strategy, we used training-test partitions in a 10-fold cross-validation procedure to build an ELNET classifier, which yielded an AUC of 0.64 (0.58-0.71) ( <0.05, Figures 1D-E) in the test sets. This analysis was repeated 100 times to build an ensemble classifier over all 100 predictors, which was then tested in the independent validation set. The ensemble classifier attained a value of AUC=0.62 (0.51-0.74) (P<0.05, Figure IF) in line with the AUC in the discovery set. In the second strategy, we trained one ELNET classifier using the whole discovery set from the top 5482 ranked CpGs, and with a built-in internal cross- validation for optimal feature selection. The resulting ELNET classifier also predicted breast cancer risk in the independent validation set (AUC=0.65, (0.54-0.76), <0.05, Figure 1G). To further demonstrate that this result could not have arisen by chance we randomised the phenotype labels 100 times in the discovery set, retrained 100 ELNET classifiers and evaluated them in the validation set. We obtained a mean AUC=0. 1
(0.41-0.65), and in only 3 runs did we observe an AUC as extreme as the observed one (P<0.05). By dividing the predicted individualised risk values into high, intermediate and low risk groups we have estimated a 3 -fold increase in the odds of developing breast cancer for those in the highest risk category compared to women with the lowest predicted risk (see Table 1 below). Table 1
Figure imgf000027_0001
Table 1 shows the distribution of cases and controls with associated odds ratios (OR), 95% confidence intervals, and P-values of significance (Fisher-test) in the three risk groups of the discovery and validation sets. Risk groups are defined based on tertiles and ranked according to the predicted risk index: High (33% with highest predicted risk), Intermediate (33% with next highest risk), Low (34% with lowest predicted risk). OR values are expressed relative to the lowest risk group. Also provided is the median time to diagnosis (tD, cases) and median last follow-up time (tLF, controls) in each risk group. NA=not applicable. Example 3
In order to shed light on the genes differentially methylated between cases and controls, we performed a GSEA on CpGs which were either hyper or hypomethylated. The top five categories of genes hypermethylated in cases were all crucially involved in stem cell differentiation and biology (Figure 2A): (1) Target genes of Nuclear inhibitor of protein phosphatase- 1 (NIPP1), which is a transcriptional repressor and contributes to the recruitment of the Polycomb Repressor Complex (PRC2), (2) A selected set of stem cell polycomb group target genes (PCGTs) previously reported to undergo widespread methylation in cancer tissue, (3) Target genes of MSXl, a developmental regulator involved in mammary development and breast cancer, (4) Genes with an AACTTT promoter motif, which are heavily enriched for
developmental transcription factors and (5) target genes of NANOG, a factor known to maintain pluripotency.
Stem cell polycomb group target genes were also highly enriched among hypermethylated cancer-risk CpG sites (Figure 2A). The degree of overlap between enriched gene sets was often insignificant (e.g NANOG targets and PCGTs), indicating that the enrichment of many gene sets were independent of each other (Figure 2A). Most importantly, these stem cell gene categories were not enriched among CpGs hypomethylated in cases, and in fact were often underenriched (Figure 2B). These observations gain special importance in light of the fact that NIPP1, PRC2, MSXl and NANOG all suppress differentiation by occupying and suppressing certain sets of genes.
Example 4
We and others have demonstrated that PCGTs are frequently methylated in cancer cells. Thus, our serum DNA methylation risk signature could in principle have been due to the presence of disseminated preneoplastic or tumour cells well in advance of clinical diagnosis of breast cancer. Alternatively, it could also reflect a systemic breast cancer predisposition. To exclude this possibility, we first asked if the time from sample draw to diagnosis has an impact on the strength of the association between DNA methylation and cancer risk. This association, as well as gene set enrichment analysis, was largely unchanged when we used a Cox-regression model framework that takes the time from sample draw to diagnosis or last follow-up into account. From the 134 cases in the discovery set, we next selected 50 who developed breast cancer earlier (i.e all within 1.5 years after sample draw) and 0 who developed the disease much later (more than 2.5 years after draw) and compared both sets separately to the 148 controls. This showed that while there were significantly more CpGs associated with cancer risk for cases detected early after sample draw, this difference was not substantial (Figure 3 A). Moreover, the top risk CpGs obtained from both sets of cases exhibited very strong correlations (Figure 3B) and overlap, and enriched GSEA categories were also very similar. In addition when applying the risk signature to the 50 cases who developed breast cancer within 1.5 years and to the 50 who developed breast cancer after 2.4 years, we find exactly the same ROC AUC.
Therefore, we conclude that the DNA methylation risk signature was not due to the presence of disseminated preneoplastic or tumour cells, but rather represents a genuinely predictive tool in currently healthy individuals.
Example 5
In order to demonstrate a link of the risk signature identified in serum DNA well in advance of breast cancer development and breast cancer biology we selected the 1500 most significant cancer risk CpGs from the serum data and asked if these CpGs were differently methylated in DNA from non-neoplastic breast and breast cancer. We found a highly significant increase of hypermethylated risk CpGs in breast cancer (Figure 4A). Strikingly, there is also a significant increase of methylation with increase of cancer grade (Figure 4A) supporting the view that the risk signature is linked to differentiation capacity. Risk CpGs hypermethylated in cases were also highly enriched for a BRCA1 functional gene network, consistent with the view that disruptions to this gene network may increase susceptibility to breast cancer. We therefore posited that our cancer risk hypermethylation signature could also be increased in the DNA of healthy BRCA1 mutation carriers who did not yet develop cancer. To address this, we analyzed DNA methylation of peripheral blood cells from 15 healthy BRCAl mutation carriers and 15 age matched non-carriers. We selected the 1 00 most significant cancer risk CpGs from the serum data and asked if these CpGs were discriminatory of BRCAl mutation status in this independent set. We observed that the cancer risk CpGs which were hypermethylated in prospective cases also showed higher methylation levels in healthy BRCAl mutation carriers compared to non-carriers (Figure 4B), while cancer-risk CpGs which were hypomethylated did not. This result was replicated in another independent set of peripheral blood samples from 7 healthy BRCAl mutation carriers and 42 non-carriers (data not shown).
In summary, our data demonstrate for the first time that DNA methylation profiles obtained in serum up to five years in advance of diagnosis have the potential to indicate breast cancer risk. Perhaps more importantly our data show that genes encoding developmental transcription factors needed for differentiation of stem cells, as well as target genes of transcription factors that are crucially involved in stem cell biology, are hypermethylated in women predisposed to breast cancer. Crucially those CpGs are also hypermethylated in breast cancer and are also significantly enriched in peripheral blood cells of BRCAl mutation carriers. Therefore, these data fit well with a stem cell origin model of cancer in which preneoplastic cells acquire an irreversible block in differentiation due to DNA methylation, increasing their susceptibility to acquire further mutations and predisposing them to neoplastic transformation.
Our study is not able to fully address whether the serum DNA methylation signature is an early detection marker (DNA from subclinical breast cancer lesions or circulating tumour cells) or is a surrogate marker for accumulating breast cancer susceptibility. Although more evidence points towards the latter: (a) The risk signature does not substantially change even if only considering cases diagnosed 2.5 - 5.0 years after sample collection, (b) Analyzing peripheral blood cells of BRCAl mutation carriers who have not yet developed breast cancer demonstrates a strong overlap with our risk signature, (c) By far the majority of DNA in serum from the U CTOCS samples is DNA from peripheral blood cells, (d) Circulating epithelial cells are very rare in healthy women (mean, 0.1±0.2 per 7.5 ml of whole blood) and in patients with benign breast disease (mean, 0.1±0.9 per 7.5 ml of whole blood). Even in women with metastatic breast cancer more than 50% have less than 5 epithelial cells in 7.5 ml of whole blood, making it extremely unlikely that these circulating epithelial or cancer cells contributed to our DNA methylation risk signature or to the strong overlap of this signature with methylation profiles specific to peripheral blood cells of BRCA1 mutation carriers.
Our findings also serve as a solid basis to develop DNA methylation based tests to predict chronic diseases like cancer. In summary our data demonstrate the potential of the epigenome to complement genetic and epidemiological models to predict breast cancer risk.
Example 6
In Figure 2B (see above for details), we demonstrate a heatmap of normalized methylation values in the discovery set and across the top 1000 cancer-risk CpGs. CpGs and samples have been clustered using hierarchical clustering and a Pearson correlation metric. Colour bars denote the two main clusters (lighter bar on the left, darker bar on the right) and if sample is a case (black) or control (white). Distribution of cases/controls is given and associated P-value is that of a Fisher-test. Right panel shows the enrichment of stem-cell related gene sets among CpGs hypermethylated in cases relative to controls. The "light/left" cluster reflects those samples which demonstrate hypermethylation of genes which are crucial in stem cell biology and the "gdark/right" cluster reflects samples with hypomethylation of these stem cell genes.
With reference to Figure 5, which is an enhanced version of Figure 2B, we have now at least 6 years of follow up since the sample was provided. Of the 180 women (134 in discovery and 48 in validation set) who developed breast cancer, 15 women died of breast cancer within six years after they provided the sample (indicated with additional vertical bars at the top of the discovery set). Women who demonstrated a stem cell hypermethylation profile had a higher chance of developing breast cancer 0.5 - 5 years after their sample was taken, but also demonstrated a substantially higher risk of dying from their breast cancer within 6 years (Figure 6, Kaplan Meier curve and likelihood ratio test pvalue).
This is the first time that a specific test performed on healthy individuals is not only indicative of the risk to develop cancer, but also the risk of whether an individual is more likely to die from the disease. These findings open up an entirely new window of opportunity for assessing the risk of a common cancer such as breast cancer: To date strategies to early detect breast cancer have been hampered by detection of abnormalities that would not become clinically relevant over a lifetime, i.e. are over- diagnosed. These over-diagnosed cancers cause huge anxiety, unnecessary treatment and are a major burden to the health system. Hence, a test which is able to indicate (up to five years in advance) the risk of developing a deadly cancer, potentially provides a massive benefit for our society, both socially and economically.
Table 2
Table 2 below shows top ranked 5482 cancer risk CpGs, all passing FDR<0.3, derived using a multivariate linear regression framework in the discovery set (148 controls and 134 cases), as described in the Examples above. We also provide the odds ratio and AUC values from logistic regression and Wilcoxon rank sum tests, respectively. Each gene is refered to as "Symbol", and each category of gene i.e. PCGTs, target of NIPP1, MSX- 1 or NANOG or genes with an AACTTT promoter motif are referred to under the appropriate titled columns ("PCGTs", "NIPP1-T", "MSX1-T", "NANOG-T" and "AACTT-T" respectively). Under these columns, "1" denotes that the gene is a "PCGTs", "NIPP1-T", "MSX1-T", "NANOG-T" or "AACTT-T" respectively. "0" denotes that the gene is not a member of that gene group. CpG Symbol NCBI t.statistics pvalue qvalue OR AUC cg07715201 GDNF 2668 4.44621 1.30E-05 0.077279929 1.85249374 0.65162364 cg22181664 CLCA1 1179 -4.39491 1.62E-05 0.077279929 0.54208291 0.64466519 cgl5321211 HNRPF 3185 4.35973 1.88E-05 0.077279929 1.82317373 0.64290036 cg21105318 ITGB6 3694 -4.34704 1.98E-05 0.077279929 0.54419033 0.63165591 eg 18967846 CLDN12 9069 4.32337 2.19E-05 0.077279929 1.82954375 0.63125252 cg05960024 CLOCK 9575 -4.29934 2.42E-05 0.077279929 0.5523098 0.63942114 cg23577242 MPPED2 744 -4.18581 3.89E-05 0.079949004 0.5412263 0.62298306 cgl8485955 TNFRSF17 608 -4.11214 5.26E-05 0.079949004 0.56651016 0.61244453 cgl2623088 MGC4562 115752 4.0608 6.48E-05 0.079949004 1.79336627 0.63503429 cg05365525 DEPDC6 64798 4.06029 6.49E-05 0.079949004 1.74347572 0.6187979 cg23523368 AMPD1 270 -4.0561 6.60E-05 0.079949004 0.56138382 0.61910044 cg26738880 DPP6 1804 -4.05252 6.70E-05 0.079949004 0.5709803 0.61925171 cg09425228 CCL20 6364 -4.04297 6.96E-05 0.079949004 0.57366768 0.63967326 cg20683151 TM4SF20 79853 -4.0343 7.20E-05 0.079949004 0.56906 0.64103469 cg21209356 CSF2RB 1439 -4.03372 7.22E-05 0.079949004 0.57617048 0.62005849 cg03547924 GDF5 8200 -4.01631 7.74E-05 0.079949004 0.56979157 0.6136547 cgl5182360 PCDH20 64881 4.01264 7.86E-05 0.079949004 1.77201927 0.63074829 cg07925687 RABL3 285282 4.01118 7.90E-05 0.079949004 1.72357784 0.63321904 cgl7430393 VSNL1 7447 4.00988 7.94E-05 0.079949004 1.73383273 0.64264825 cgl3593287 SPTB 6710 3.96524 9.48E-05 0.090674413 1.73686064 0.61572207 cgl0654016 C12orf31 84298 3.94481 0.000102792 0.091018524 1.74552146 0.62580678 cg22487322 IL20RA 53832 -3.9401 0.000104712 0.091018524 0.57438128 0.63437878 cgl6298282 KIAA0776 23376 3.92034 0.000113157 0.093395938 1.72934842 0.6260589 cgl l304524 TSSK4 283629 -3.89926 0.000122874 0.093395938 0.58422396 0.62454619 cg05600174 C9orf95 54981 3.87698 0.000134006 0.093395938 1.71774563 0.63039532 cg04189838 CYP2C19 1557 -3.87497 0.000135053 0.093395938 0.57933807 0.63811013 cg01367992 LY9 4063 -3.84236 0.000153211 0.093395938 0.58320747 0.60689794 cg03349953 PCDHB5 26167 3.84001 0.000154605 0.093395938 1.71455808 0.6170835 cgl3958426 Clorfll4 57821 3.8277 0.000162104 0.093395938 1.71024134 0.6232856 cg04619381 LOC222171 222171 3.82477 0.000163943 0.093395938 1.67663908 0.62989109 cgl5736336 PLCZ1 89869 -3.82276 0.000165213 0.093395938 0.59153164 0.63669827 cgl5473868 MT1X 4501 3.82052 0.000166639 0.093395938 1.67418591 0.62651271 cg21581873 PLEKHA6 22874 3.81849 0.000167942 0.093395938 1.68009611 0.61849536 cg20443314 VPS25 84313 3.817 0.000168906 0.093395938 1.717277 0.62031061 cg04127255 PSG2 5670 -3.81388 0.000170939 0.093395938 0.58720725 0.61849536 cg20401549 PRKY 5616 3.79605 0.000183006 0.096384093 1.72391636 0.60377168 cg06324671 KRTAP19-7 337974 -3.77871 0.00019551 0.096384093 0.59583205 0.62273094 cg25924032 BMS1L 9790 3.77754 0.000196378 0.096384093 1.72598745 0.59772086 cg08550724 C6orfl82 285753 -3.77729 0.000196569 0.096384093 0.59489753 0.62893304 cgl2554857 PGDS 27306 3.75981 0.000210051 0.097975833 1.72649486 0.63049617
cgl5534084 ZNF649 65251 3.75936 0.000210412 0.097975833 1.69882461 0.63261396 cg23357981 GRP 2922 -3.75286 0.000215655 0.097975833 0.58165305 0.6040238 cg08466074 SMAP 10944 3.74722 0.000220309 0.097975833 1.66870831 0.61920129 cg25226014 CXCR6 10663 -3.72475 0.000239783 0.098220554 0.60092005 0.61431021 cg05360220 TNFRSF14 8764 3.72185 0.000242412 0.098220554 1.66356143 0.64073215 cg20641660 Cllorf30 56946 3.7179 0.000246042 0.098220554 1.68755245 0.62384026 cgl2532500 STARD13 90627 3.7115 0.000252022 0.098220554 1.67663101 0.63210972 cg07236943 PEG10 23089 3.71115 0.000252353 0.098220554 1.71046356 0.62303348 cg02097420 HRG 3273 -3.7088 0.000254591 0.098220554 0.59337865 0.6224284 cg09501516 RGS4 5999 3.70648 0.000256814 0.098220554 1.68476622 0.62868092 cg04317031 FAM73B 84895 3.70032 0.000262806 0.098541572 1.66110524 0.62268052 eg 10099900 PSMF1 9491 -3.69407 0.000269015 0.098929878 0.59852023 0.61153691 cg06548519 LYZL6 57151 -3.68402 0.000279304 0.10037672 0.58940777 0.60689794 cgl7277529 FGF3 2248 3.6731 0.000290898 0.10037672 1.67950616 0.63039532 cg00427635 TBC1D21 161514 3.66167 0.000303515 0.10037672 1.62479724 0.6172852 cg03889226 0LIG3 167826 3.65373 0.00031259 0.10037672 1.6555617 0.62570593 eg 19894943 KTI12 112970 3.65315 0.000313262 0.10037672 1.71083498 0.61516741 cg09313705 H0XB2 3212 3.64286 0.000325419 0.10037672 1.63257114 0.62706737 cg06290096 PHLDB1 23187 -3.64007 0.000328794 0.10037672 0.59702542 0.62676483 cgl4511156 OSCAR 126014 3.63992 0.000328979 0.10037672 1.64807503 0.61758774 cg26369642 C8otf72 90362 -3.6374 0.000332045 0.10037672 0.60511968 0.62888261 cg24448259 CPVL 54504 3.63599 0.000333786 0.10037672 1.67595917 0.61436063 cgl l304234 IL18 3606 3.63496 0.00033505 0.10037672 1.67200688 0.5980234 cg07588664 PPHLN1 51535 3.62204 0.000351394 0.10037672 1.63717704 0.61645321 cgl5569512 C14orfl53 84334 3.62136 0.000352265 0.10037672 1.63294564 0.63175676 cg02519218 CHFR 55743 -3.6193 0.000354953 0.10037672 0.59508922 0.62141993 cg23983366 RA BP6 26953 3.61392 0.000362044 0.10037672 1.65934237 0.62126866 cg24323726 ZBED2 79413 -3.60832 0.000369552 0.10037672 0.59442253 0.63614361 cg20879768 TCEB3B 51224 -3.60633 0.000372261 0.10037672 0.60982795 0.61188988 cgl5926557 KATNA1 11104 -3.60334 0.00037636 0.10037672 0.59951316 0.61995764 cg24063382 MAS1L 116511 -3.60091 0.000379737 0.10037672 0.6017764 0.62923558 cg00336605 NR1H2 7376 3.5994 0.000381831 0.10037672 1.64060447 0.61995764 cgl4747225 POLR3K 51728 3.59844 0.000383179 0.10037672 1.65606201 0.62152078 eg 14480463 I T1 26173 -3.59076 0.000394091 0.101540239 0.59828307 0.61410851 cg03679305 SLC2A5 6518 3.58594 0.000401091 0.101540239 1.65466375 0.60992336 cg25423111 TSSK4 283629 -3.58218 0.000406642 0.101540239 0.6114329 0.62666398 cg00545573 TAOK3 51347 3.57499 0.00041744 0.101540239 1.63112289 0.6162263 cg07888040 GLDN 342035 -3.5711 0.00042339 0.101540239 0.61008943 0.62177289 cg05303448 AACS 65985 3.56926 0.000426231 0.101540239 1.62125875 0.61662969 cg21856603 ITGAE 3682 -3.56816 0.000427935 0.101540239 0.61575236 0.62293263 cg23181170 GABRP 2568 -3.56678 0.000430099 0.101540239 0.60479911 0.61627672 eg 14368286 PRAF2 11230 -3.56083 0.000439487 0.102491287 0.6137311 0.59908229
cg02756614 FER1L3 26509 3.55545 0.000448155 0.103253481 1.65689154 0.61783986 cg25881193 BTN2A2 10385 3.55186 0.000454028 0.103359935 1.6210757 0.64078257 cgl6466334 MMP3 4314 -3.54549 0.000464609 0.103359935 0.59784704 0.61103267 cgl7022635 FUS 2521 3.53969 0.000474461 0.103359935 1.62859913 0.60271279 cgl6752778 PIGK 10026 3.53748 0.000478271 0.103359935 1.65899335 0.60957039 cg03225779 COL27A1 85301 3.52574 0.000498951 0.103359935 1.64444084 0.61758774 cg27277403 KMO 8564 3.524 0.00050209 0.103359935 1.61985672 0.62172247 cg03993463 KCNJ15 3772 -3.52235 0.000505079 0.103359935 0.61091298 0.60881404 cg25299676 MET 4233 3.52079 0.000507913 0.103359935 1.6546297 0.63619403 cg08840010 TNFRSF9 3604 3.52023 0.000508954 0.103359935 1.63473928 0.61552037 cgl2604192 KCNA10 3744 -3.51579 0.000517138 0.103359935 0.61169861 0.61027632 eg 12444340 RBM5 10181 3.51237 0.000523533 0.103359935 1.62407567 0.60649455 cg04052038 CLDN8 9073 -3.50963 0.000528713 0.103359935 0.61343067 0.60140178 cgl8796520 NDUFA9 4704 3.50825 0.000531325 0.103359935 1.62594521 0.62787414 cg26986815 CASP8 841 3.50554 0.000536516 0.103359935 1.63120449 0.62257967 cg08629913 IGFBP6 3489 3.50545 0.000536691 0.103359935 1.60941721 0.61546995 cg00746083 CHD8 57680 3.50463 0.000538268 0.103359935 1.60525779 0.62363856 cg22830590 SCRN3 79634 3.50348 0.000540503 0.103359935 1.62719153 0.62575635 cgl5016628 BRS3 680 -3.49905 0.000549148 0.103701029 0.62055841 0.61118395 cg02998425 ADAM21 8747 -3.49486 0.000557436 0.103701029 0.61910233 0.6310004 cg08693325 LUZP4 51213 -3.48872 0.000569798 0.103701029 0.61344988 0.61506656 cg25310567 GALNTL5 168391 -3.488 0.000571284 0.103701029 0.62537627 0.6014522 cgl0751811 CYP4Z1 199974 -3.48711 0.000573089 0.103701029 0.6209325 0.59721662 cg00669856 SPRY1 10252 3.48067 0.000586425 0.103701029 1.62396251 0.61516741 cgl0951619 FAM5C 339479 3.48031 0.000587161 0.103701029 1.64512956 0.61960468 cgl7524624 GSTK1 373156 3.47773 0.000592592 0.103701029 1.61853245 0.62353772 cg01798589 STAC 6769 3.47559 0.00059712 0.103701029 1.62981557 0.63200888 cg21410991 ISL1 3670 3.46851 0.000612357 0.103701029 1.61158441 0.62943727 cg21295467 L0H11CR2A 4013 3.46702 0.00061561 0.103701029 1.61056715 0.63200888 cg02774963 KEL 3792 -3.46661 0.000616523 0.103701029 0.62119545 0.61713393 cg25125453 C20orf38 55304 3.46436 0.000621454 0.103701029 1.61770662 0.61042759 cg08308510 C20orfl73 140873 -3.46397 0.00062233 0.103701029 0.61442628 0.6187979 cg06281795 CALB1 793 3.46158 0.000627638 0.103701029 1.59962655 0.6222267 eg 15502446 HSPC138 51501 3.45644 0.000639177 0.103701029 1.64937312 0.60341872 cgl6855929 EGLN1 54583 -3.4533 0.000646342 0.103701029 0.62120574 0.61337737 cgl3897449 PFKFB1 5207 -3.45239 0.000648424 0.103701029 0.61822561 0.60099839 cg25140370 IRF4 3662 3.4523 0.000648635 0.103701029 1.62214002 0.60967124 cg22436411 FCGR2B 2213 3.44915 0.000655892 0.103701029 1.67039287 0.60891489 cg07621456 CCDC48 79825 -3.44701 0.000660887 0.103701029 0.61305248 0.60503227 cg07957491 UCK1 83549 3.44671 0.000661589 0.103701029 1.6068116 0.60866277 cg08373610 C2orfll 130132 3.44382 0.000668398 0.103916557 1.64226763 0.61199072 cgl5320474 UBD 10537 -3.43953 0.000678606 0.104652695 0.62501696 0.61188988
cgl9258882 ERBB3 2065 3.43664 0.000685556 0.104878685 1.6090544 0.60170432 cg25070010 MYRIP 25924 3.43136 0.000698453 0.106003689 1.58146508 0.61627672 cg08559914 ACE2 59272 -3.42228 0.000721147 0.106529464 0.61981297 0.6196551 cgl0238171 BDKRB1 623 -3.42069 0.000725199 0.106529464 0.6183714 0.62310912 cg06193397 ENPP2 5168 3.41907 0.000729329 0.106529464 1.62284975 0.6100242 cg03780486 OR6A2 8590 -3.41757 0.00073318 0.106529464 0.6180082 0.59091368 cg07232688 LRRC39 127495 -3.41731 0.000733856 0.106529464 0.6111852 0.60760387 cgl7124509 C17orf57 124989 3.41673 0.000735342 0.106529464 1.58974589 0.60114966 cg26232187 NTRK3 4916 3.40997 0.000753012 0.107416837 1.56637781 0.60170432 cgl9953406 KLK7 5650 3.40256 0.000772831 0.107416837 1.57118312 0.61869706 cg26822241 CYP2C9 1559 -3.40138 0.000776025 0.107416837 0.61749974 0.60972166 cg00532335 LGI1 9211 -3.4001 0.000779506 0.107416837 0.62933751 0.61325131 cg06817917 BMPR1A 657 3.39949 0.000781182 0.107416837 1.59230566 0.58874546 cg09816180 GC 2638 -3.3993 0.000781697 0.107416837 0.62169841 0.59519968 cg02210123 RHOJ 57381 3.39888 0.000782859 0.107416837 1.62785273 0.59741831 cgl6927136 RPL35A 6165 3.39655 0.000789258 0.107416837 1.60314605 0.61264623 cg07172256 ERBB2IP 55914 3.39555 0.000792022 0.107416837 1.58751271 0.57971965 cg24469803 POLR3A 11128 3.38813 0.000812823 0.10816375 1.61389318 0.61113352 cgl l976166 TGFB2 7042 3.38551 0.000820282 0.10816375 1.63219214 0.61824324 cg20261167 SPP1 6696 3.38519 0.000821207 0.10816375 1.58903509 0.60276321 cgl4107638 MAGEA5 4104 -3.38355 0.000825909 0.10816375 0.62720725 0.61844494 cg20530314 AGTR1 185 3.38117 0.000832786 0.10816375 1.58528835 0.59635942 cg27398547 C14orf39 317761 3.37872 0.000839942 0.10816375 1.61720443 0.61466317 cg27032352 C21orf94 246705 3.3775 0.000843509 0.10816375 1.59608332 0.61897439 cg23279136 ABCB7 22 -3.37744 0.000843673 0.10816375 0.60958211 0.58007261 cgl6729794 MOBP 4336 -3.37583 0.000848435 0.10816375 0.63469776 0.61037717 cg04368919 EFNB1 1947 3.37247 0.000858408 0.10871043 1.5904651 0.62802541 eg 11899895 TAX1BP1 8887 3.36951 0.000867277 0.109110995 1.60924518 0.62172247 cg25226247 TFAP2B 7021 3.35993 0.000896619 0.110260578 1.56741242 0.61390682 cg01713938 IFNA13 3447 -3.35974 0.000897194 0.110260578 0.63032798 0.60452804 cgl3364756 CYP3A43 64816 -3.35914 0.00089906 0.110260578 0.63092593 0.61264623 cg04365980 CLEC3A 10143 -3.35901 0.000899478 0.110260578 0.62802789 0.63037011 cg21578207 Clorfl64 55182 3.35715 0.000905284 0.110265434 1.59857508 0.59862848 cg25294646 OBFC1 79991 3.35033 0.000926924 0.112043655 1.59848304 0.61995764 cgl3729392 C14orfll2 51241 3.34833 0.000933349 0.112043655 1.57457842 0.60841065 cg23129478 ST8SIA5 29906 3.34706 0.00093746 0.112043655 1.6017982 0.6076543 cgl2455187 CCL5 6352 -3.34285 0.000951211 0.112911736 0.63286039 0.61476402 cgl7767184 DHFRL1 200895 3.34123 0.000956532 0.112911736 1.61936342 0.61799113 cg21093060 TXLNA 200081 -3.33933 0.000962832 0.112958114 0.63396822 0.61526825 cg26771217 CLK2 1196 3.33057 0.00099236 0.115112733 1.57668962 0.60356999 cgl8808261 SATB1 6304 3.33031 0.000993237 0.115112733 1.59545578 0.59958653 cg07510052 HIGD2A 192286 -3.32709 0.001004303 0.115276371 0.62089553 0.61037717
cg00037763 SETBP1 26040 -3.3264 0.001006705 0.115276371 0.64472235 0.60498185 cg06320982 FU10815 55238 3.31988 0.001029525 0.116976499 1.57955083 0.60417507 cg07328579 GLT8D2 83468 3.31788 0.001036617 0.116976499 1.60361992 0.60583905 cgl0576828 LRRC7 57554 -3.31695 0.001039904 0.116976499 0.62828142 0.62041146 cg03430998 TLR1 7096 3.31286 0.001054631 0.117858768 1.59911179 0.62479831 cgl5414833 RPIB9 154661 3.30942 0.001067107 0.117858768 1.55840506 0.62076442 cg04595835 WDFY3 23001 3.30668 0.001077185 0.117858768 1.58794648 0.61990722 cg27486427 RARB 5915 3.30441 0.001085598 0.117858768 1.58351014 0.61587334 cg02506908 HPD 3242 -3.30363 0.0010885 0.117858768 0.63414583 0.59197257 cgl3696887 KRTHB2 3888 -3.30197 0.001094687 0.117858768 0.63563233 0.60689794 cg02280309 PKLR 5313 -3.30066 0.001099586 0.117858768 0.63447866 0.60109923 cgl4472778 MTHFR 4524 -3.29888 0.001106301 0.117858768 0.63397224 0.59832594 cg21842274 CRHBP 1393 3.29811 0.001109215 0.117858768 1.59149975 0.62187374 cg20751395 KCNQ1 3784 -3.29639 0.00111576 0.117858768 0.64487299 0.60256152 cgl8665023 ATP50 539 3.29463 0.001122507 0.117858768 1.56947958 0.62479831 cg05596294 LPPR4 9890 3.28908 0.001143966 0.117858768 1.57562866 0.6018808 cg20695562 USP33 23032 3.28809 0.001147828 0.117858768 1.57180524 0.58864462 cg27513764 EFCAB3 146779 -3.28532 0.001158723 0.117858768 0.63487581 0.6162263 cg06096336 HTR2B 3357 3.28409 0.001163566 0.117858768 1.58403617 0.6181424 cg25682559 FH0D3 80206 3.28229 0.001170722 0.117858768 1.58792224 0.60296491 cgl2017007 PHF12 57649 3.2817 0.001173061 0.117858768 1.56135552 0.61703308 cg24325790 CCL23 6368 -3.28121 0.001175016 0.117858768 0.63578942 0.58919927 cgl3765961 MS4A1 931 -3.27961 0.001181455 0.117858768 0.64093423 0.59207342 cgl3919215 P0LR2K 5440 3.27796 0.00118808 0.117858768 1.58522101 0.60548608 cg02430692 PEX5L 51555 3.27694 0.001192212 0.117858768 1.55993197 0.61486487 cgl l822932 LM02 4005 3.27658 0.001193673 0.117858768 1.59613596 0.61148649 cg06337239 DDX58 23586 3.27539 0.001198515 0.117858768 1.56555012 0.60397338 cgl8085517 TRPM 1 4308 -3.2746 0.001201747 0.117858768 0.63753303 0.59151876 cg06476337 NDUFS4 4724 3.27458 0.001201827 0.117858768 1.57145847 0.61229326 cg20837735 SERPINB5 5268 -3.26826 0.001227882 0.118380965 0.62312843 0.60518354 cg20543416 MMP25 64386 3.26583 0.001238035 0.118380965 1.5617078 0.60311618 cg06350796 CXorf41 139212 3.26415 0.001245125 0.118380965 1.54411947 0.61315046 cg24603941 MIA2 117153 -3.26362 0.001247349 0.118380965 0.63870213 0.60588947 cgl3158571 CYP4X1 260293 3.26333 0.001248586 0.118380965 1.56611968 0.60286406 cg02229946 IL1F7 27178 -3.26308 0.001249632 0.118380965 0.63225886 0.60362041 cgl5737168 TECTA 7007 -3.26246 0.001252254 0.118380965 0.61724978 0.59857806 cg04825431 ZNF239 8187 -3.26142 0.001256677 0.118380965 0.63570399 0.60931827 cgl8992201 DPPA2 151871 -3.25381 0.001289477 0.118704866 0.64110079 0.59968737 cg26061772 CASC3 22794 3.25062 0.001303449 0.118704866 1.60027479 0.60412465 cgl8794577 GRIN3A 116443 3.24901 0.001310568 0.118704866 1.55629752 0.61148649 cgl5995002 RAD54B 25788 3.24807 0.001314734 0.118704866 1.59794574 0.60291448 cgl3257485 NXT2 55916 -3.24803 0.001314915 0.118704866 0.64586938 0.61093183
cgl3274713 TBX2 6909 -3.24789 0.001315525 0.118704866 0.63789867 0.60760387 cg07894717 CORT 1325 -3.24694 0.001319767 0.118704866 0.63751621 0.59207342 cg05769161 B4GALNT3 283358 3.24669 0.001320877 0.118704866 1.5494071 0.62126866 cg03455024 SLC12A3 6559 -3.24636 0.001322332 0.118704866 0.6377843 0.60281364 cgl5541315 REX02 25996 3.24388 0.001333444 0.118704866 1.57219759 0.60432634 cg03017653 TTC13 79573 3.2432 0.001336501 0.118704866 1.55717445 0.60626765 cg02547439 ELM02 63916 3.2432 0.001336504 0.118704866 1.54982505 0.6083098 cgl4372394 CHST10 9486 3.23941 0.001353681 0.118704866 1.56908785 0.6284288 cg25538571 FU46365 401459 3.23822 0.001359132 0.118704866 1.56415098 0.60377168 cgl5401952 KCNIP4 80333 3.23742 0.00136278 0.118704866 1.55366821 0.63110125 cg25455753 C15orf32 145858 -3.23709 0.001364291 0.118704866 0.63614237 0.60291448 cgl8979491 LBP 3929 -3.2368 0.001365642 0.118704866 0.64199393 0.62116781 cgl6114640 THSD1 55901 3.2329 0.001383667 0.119300189 1.56642636 0.60725091 cg20331177 KRTAP4-2 85291 -3.22902 0.00140187 0.119300189 0.63829164 0.57936668 cg06251129 SSR2 6746 3.22883 0.001402728 0.119300189 1.57564987 0.59086325 cgl7574251 FNDC8 54752 -3.22845 0.001404551 0.119300189 0.63823588 0.59298104 cg09152089 IL22RA1 58985 -3.22521 0.001419917 0.119300189 0.64950843 0.60362041 cg22730560 SNRPA1 6627 -3.2244 0.001423763 0.119300189 0.62082764 0.59640984 eg 10849854 GREB1 9687 3.22245 0.001433137 0.119300189 1.55495749 0.60921743 cgl3968390 SULT1C1 6819 -3.22236 0.00143356 0.119300189 0.64577487 0.59691408 cg26106720 STX12 23673 -3.22203 0.001435132 0.119300189 0.6278283 0.60372126 cg02099418 CD28 940 3.2209 0.001440611 0.119300189 1.58077321 0.58687979 cg22021786 WFDC8 90199 -3.21988 0.001445539 0.119300189 0.63613134 0.59519968 cgl0703331 TRIM 24 8805 3.2195 0.001447354 0.119300189 1.57737093 0.59966216 cg06206628 FRMPD2 143162 -3.21634 0.001462782 0.11978165 0.63770698 0.61597418 cg20895028 CDH26 60437 -3.21572 0.001465826 0.11978165 0.64433721 0.60800726 cg07623294 ELAVL2 1993 3.21426 0.00147303 0.11978165 1.560209 0.61390682 cg04916911 NTS 4922 3.20765 0.001505948 0.11978165 1.57441782 0.62056273 cg20469837 GALNT5 11227 3.20636 0.00151247 0.11978165 1.53364879 0.60770472 cgl0883303 H0XA13 3209 3.2057 0.001515767 0.11978165 1.55109904 0.59736789 cgl2045676 CRTC1 23373 3.20525 0.001518062 0.11978165 1.56159754 0.60886446 cg06601473 MGC34830 120196 -3.20524 0.001518137 0.11978165 0.64244749 0.59988907 cgl8220284 TAF5L 27097 3.20482 0.001520263 0.11978165 1.53797209 0.61032675 cg00005847 H0XD3 3232 3.20421 0.001523347 0.11978165 1.56058275 0.6059399 cg07935264 IL1B 3553 3.20323 0.001528326 0.11978165 1.56739013 0.5988806 cgl0307548 S0D3 6649 3.20323 0.00152836 0.11978165 1.55054913 0.59146833 cg02037013 MC4R 4160 -3.1961 0.001565127 0.122162533 0.64712574 0.60646934 cgl6478792 RGSL1 353299 -3.19436 0.001574264 0.122376169 0.64395459 0.60583905 cg20337106 C6orfl39 55166 3.19098 0.001592068 0.123259148 1.54554004 0.61163776
RP11- cg05538387 529110.4 25911 3.18926 0.001601184 0.123465016 1.55254963 0.59005647 cg24012157 DDX50 79009 3.18578 0.001619855 0.123812538 1.5205023 0.60286406
cg05546383 0TUD4 54726 -3.18434 0.001627632 0.123812538 0.63787678 0.59787213 cgl2879425 BRDG1 26228 3.18386 0.001630235 0.123812538 1 .59865304 0.61133522 cgl3875807 JMJD2C 23081 3.18108 0.001645344 0.123812538 1 .52539762 0.59792255 cgl8223379 BPIL3 128859 -3.18034 0.001649402 0.123812538 0 .64786145 0.61163776 cgl8636558 SLC15A2 6565 -3.18026 0.001649851 0.123812538 0, .65174359 0.61098225 cg22402007 NTRK2 4915 3.17767 0.001664086 0.123812538 1 .54410716 0.60810811 cg02192965 SLC3A1 6519 -3.17699 0.001667829 0.123812538 0 .63898382 0.61224284 cg25890048 0R5I1 10798 -3.17345 0.001687535 0.123812538 0, .64125039 0.6093687 cg02552945 C5 727 -3.17339 0.00168787 0.123812538 0, .64618884 0.61080577 cg01193293 SIGLEC7 27036 -3.17258 0.0016924 0.123812538 0 .64624287 0.60725091 cg04223956 NEK7 140609 -3.17211 0.00169504 0.123812538 0, .64555036 0.6059399 cg00832994 ATPAF1 64756 3.17158 0.001698009 0.123812538 1.528984 0.6040238 cgl2053284 SYT4 6860 3.17023 0.001705618 0.123812538 1 .56843903 0.60886446 cg02415431 IGLL1 3543 3.16981 0.001708003 0.123812538 1 .54402996 0.60972166 cg26660631 FU32011 148930 -3.1686 0.001714879 0.123812538 0, .64495724 0.5997378 cg09309269 PSMD11 5717 3.16844 0.001715758 0.123812538 1 .51453448 0.61466317 cg25488206 RBM9 23543 3.1652 0.001734285 0.124419993 1 .55959688 0.6014522 cg09081544 MUC13 56667 -3.16469 0.001737189 0.124419993 0, .64907511 0.61410851 cg20162076 LY86 9450 -3.15589 0.001788463 0.126656867 0.655459 0.59333401 cg05564266 C6orf204 387119 -3.1555 0.001790782 0.126656867 0, .64899606 0.61511698 cg05825950 CR1 1378 3.15508 0.001793257 0.126656867 1.5389999 0.60669625 cg22110261 PGA PI 80055 3.15374 0.001801168 0.126656867 1 .55143512 0.61304962 cg23709121 C14orfl49 112849 3.15368 0.001801537 0.126656867 1 .57709762 0.60639371 cg24597988 SELL 6402 -3.15008 0.001823038 0.127699029 0, .64190196 0.60246067 cg04878152 AGTR1 185 3.14878 0.001830903 0.127704753 1 .52147748 0.5864764 cg01684901 C3orf40 131408 -3.14466 0.001855888 0.127704753 0, .64560439 0.58889673 cg03359285 T0P2A 7153 3.14446 0.001857118 0.127704753 1 .54223486 0.61975595 cgl3406768 C2orf33 56947 -3.1441 0.001859328 0.127704753 0, .65221207 0.59398951 cg24426405 AGR2 10551 -3.14342 0.001863472 0.127704753 0, .64885447 0.57407221 cg09847584 RIMBP2 23504 -3.14305 0.001865717 0.127704753 0 .64894282 0.59661154 cgl8215716 TMEMl l l 55831 3.14238 0.001869867 0.127704753 1 .57292299 0.60946954 cg26741595 HIST1H2BD 3017 3.14045 0.001881775 0.12772372 1 .54792383 0.59131706 cgl l809091 PCDHB7 56129 3.14017 0.001883503 0.12772372 1 .53732336 0.62318475 cg26354398 RGS3 5998 -3.13888 0.001891516 0.127735665 0, .64904441 0.60437677 cg21291985 BTBD4 140685 -3.13731 0.001901258 0.127735665 0, .65269584 0.60362041 cg22188495 PRICKLEl 144165 3.13692 0.001903718 0.127735665 1 .53645341 0.60790641 cg03173722 RUFY3 22902 -3.13487 0.001916564 0.128147976 0, .64972784 0.58534187 cg24576425 GALNT5 11227 3.1336 0.001924582 0.128235679 1 .56477469 0.60951997 cgl8766755 SPRR2A 6700 -3.13105 0.001940734 0.128289318 0 .64459814 0.60588947 cgl9632206 FAM5C 339479 3.12909 0.001953262 0.128289318 1 .56120575 0.59318274 cg26390526 FLG 2312 -3.12894 0.001954221 0.128289318 0, .64528031 0.59993949 cgl6579101 NOLI 4839 3.12865 0.001956117 0.128289318 1 .58385383 0.64113554
cg20305726 DEFB126 81623 -3.12667 0.001968859 0.128289318 0.64962612 0.59061113 cg07602200 P2RX7 5027 3.12593 0.001973579 0.128289318 1.54417582 0.59898144 cg22875391 FAM79B 285386 -3.12516 0.00197856 0.128289318 0.64713168 0.59721662 cgl3982505 KCNJ13 3769 -3.12258 0.001995362 0.128289318 0.64008133 0.59938483 cg08899632 ZFP64 55734 3.1225 0.001995911 0.128289318 1.5379776 0.5971662 cg06352750 SDPR 8436 3.12137 0.002003286 0.128289318 1.5459513 0.60200686 cgl3897627 FU44674 400535 -3.11915 0.002017877 0.128289318 0.65545786 0.61128479 cgl8931888 A4GNT 51146 -3.11735 0.002029818 0.128289318 0.65453338 0.58239209 cgl7651821 HIST1H4L 8368 3.11668 0.002034249 0.128289318 1.55106081 0.60165389 cg00729275 C18orfl6 147429 -3.11588 0.002039599 0.128289318 0.64249303 0.59454417 cgl2598364 GCAT 23464 3.11517 0.002044284 0.128289318 1.53232771 0.59767043 cg05845357 PGEA1 25776 3.11467 0.002047657 0.128289318 1.51566106 0.62020976 eg 11944393 CSPG6 9126 3.11321 0.00205745 0.128289318 1.55226712 0.60820896 cgl0677144 MYOM 1 8736 -3.11301 0.00205879 0.128289318 0.64849221 0.59837636 cg04340502 GSTA3 2940 3.11292 0.002059371 0.128289318 1.52873363 0.60215813 cg08668790 ZNF154 7710 3.1123 0.002063534 0.128289318 1.51576784 0.61456232 cgl9595170 SRF 6722 -3.1117 0.002067587 0.128289318 0.65119763 0.59469544 eg 19042062 KCNJ2 3759 3.11091 0.002072977 0.128289318 1.52938462 0.59434248 cgl3847070 KLHL3 26249 3.10955 0.002082185 0.128443475 1.54646042 0.61234369 cg20066677 CHFR 55743 -3.10835 0.002090323 0.128530852 0.63645252 0.61244453 cgl8022926 MAWBP 64081 3.10603 0.002106223 0.12861118 1.51307697 0.59620815 cg04845579 SULF1 23213 3.10469 0.002115424 0.12861118 1.5210996 0.61574728 cg03617456 EXOSC10 5394 3.10355 0.002123311 0.12861118 1.52186691 0.60004034 cg25465634 DLG7 9787 3.1029 0.002127758 0.12861118 1.5544725 0.60261194 cg03059018 SIX4 51804 3.10268 0.002129316 0.12861118 1.53710364 0.60699879 cgl2424907 TAS2R49 259295 -3.1023 0.002131982 0.12861118 0.63877131 0.60667104 cg26265060 SON 6651 3.10099 0.002141074 0.128753494 1.5448071 0.61229326 cgl4003512 PLGLB2 5342 -3.09439 0.002187543 0.130150367 0.65896426 0.60261194 cg08307963 GJA5 2702 3.09357 0.002193329 0.130150367 1.5146256 0.59615773 cg03712237 SSX2 6757 -3.09257 0.002200476 0.130150367 0.64924562 0.61355385 cgl0507231 PIK3C2B 5287 -3.0925 0.002201003 0.130150367 0.64297253 0.59635942 cg02880679 MBTD1 54799 -3.09244 0.002201446 0.130150367 0.63637696 0.60442719 cg20308679 FRZB 2487 3.0906 0.002214591 0.130150367 1.54624099 0.60351956 cg21226225 TXNRD1 7296 3.0902 0.002217467 0.130150367 1.54165477 0.6119403 cgl l062095 C5orfl5 56951 3.08914 0.002225166 0.130150367 1.53934068 0.60185559 cgl3274254 GULP1 51454 3.08908 0.002225557 0.130150367 1.53695554 0.59323316 cgl0848367 SCGB1D2 10647 -3.08744 0.002237417 0.130424062 0.64984614 0.60014119 eg 11064797 C5orfl6 285613 -3.08656 0.002243878 0.130424062 0.64958602 0.60735176 cgl9584733 DENND4C 55667 -3.08502 0.002255087 0.130678377 0.65815833 0.6012505 cg25293251 GOLGA5 9950 3.08172 0.002279333 0.13168433 1.53713393 0.61834409 cgl5091410 IL31RA 133396 -3.07837 0.00230416 0.132717708 0.66171461 0.59595603 cgl l901954 Clorf73 25896 3.07375 0.002338841 0.133019881 1.55235643 0.59282977
cg01143454 C20orfl41 128653 3.07267 0.002347022 0.133019881 1.52036002 0.58874546 cg05141400 MAGEB4 4115 -3.072 0.002352113 0.133019881 0.66241869 0.60472973 cg06270401 DYRK4 8798 3.07104 0.00235943 0.133019881 1.53515549 0.59620815 cg04599297 GAD2 2572 3.07091 0.002360415 0.133019881 1.53233733 0.59918314 cgl4930674 SLC12A1 6557 -3.07041 0.002364218 0.133019881 0.65148476 0.60140178 cg00342530 GARNL3 84253 -3.07029 0.002365152 0.133019881 0.65539085 0.60921743 cgl6507522 SERPINA3 12 -3.06822 0.002381002 0.133019881 0.65723609 0.61244453 cg01305421 IGF1 3479 3.06757 0.002386027 0.133019881 1.52239021 0.6059399 cg27607639 UNC119 9094 3.06583 0.002399494 0.133019881 1.51306363 0.5849637 cgl8593668 GNAZ 2781 3.06508 0.002405309 0.133019881 1.51917847 0.6050827 cg09497789 SPAG17 200162 3.06501 0.002405855 0.133019881 1.50759723 0.58637556 cg22183706 CALCA 796 3.06385 0.002414825 0.133019881 1.52969494 0.61249496 cg09874127 UBE1L 7318 3.06382 0.002415054 0.133019881 1.51079695 0.61234369 cg08637669 C9orfl02 56959 -3.0635 0.002417598 0.133019881 0.65914594 0.59893102 cgl7237813 TTLL7 79739 -3.06255 0.00242496 0.133019881 0.64540389 0.59474587 cgl6521028 GLIPR1 11010 3.06221 0.002427658 0.133019881 1.51972922 0.59156918 cg22512531 CRT AM 56253 -3.05873 0.002455032 0.133959346 0.64752017 0.59832594 cg01446692 CER1 9350 -3.05825 0.002458814 0.133959346 0.65664031 0.60079669 cg07453748 MGMT 4255 -3.05614 0.002475556 0.134137714 0.64933693 0.59535095 cg08771429 KRIT1 889 3.05607 0.002476117 0.134137714 1.56434674 0.59091368 cg26806924 PROCR 10544 3.0516 0.002511943 0.135694112 1.5021907 0.58526624 cg24777710 NAG8 27099 -3.04826 0.002539063 0.136350387 0.65148537 0.59998992 cg26538349 FU20035 55601 3.04759 0.002544573 0.136350387 1.54454194 0.60160347 cg08763351 SPRR4 163778 -3.04748 0.002545483 0.136350387 0.65780708 0.61007463 cg26946769 MAPK4 5596 -3.04488 0.002566778 0.136622007 0.65013919 0.59968737 cg08290628 COR02B 10391 -3.04436 0.002571096 0.136622007 0.66342446 0.60135135 cgl0375110 CHRNA9 55584 -3.04287 0.002583393 0.136622007 0.662656 0.60094796 cg20610545 WNK1 65125 3.04233 0.002587842 0.136622007 1.51879871 0.57175272 cg09519758 C9orf68 55064 -3.04197 0.002590832 0.136622007 0.65569999 0.60150262 cg05761971 FAM82A 151393 -3.04106 0.002598425 0.136622007 0.65615883 0.60447761 cg02105856 PIGR 5284 -3.04018 0.002605783 0.136622007 0.66078708 0.59141791 cg27146152 BIRC4BP 54739 3.03995 0.002607709 0.136622007 1.52577456 0.60372126 eg 18946226 MYR8 23026 -3.03858 0.002619153 0.136654217 0.66588396 0.6023094 cg01897036 SCTR 6344 -3.03472 0.002651756 0.136654217 0.6517583 0.58627471 cg06255227 NPBWR2 2832 -3.03432 0.002655131 0.136654217 0.65617212 0.58945139 cg00368022 FU11193 55322 3.03405 0.00265738 0.136654217 1.51659056 0.60120008 cgl4178991 RCHY1 25898 -3.03266 0.00266928 0.136654217 0.65676993 0.60946954 cgl2453778 COMMD1 150684 3.03251 0.002670556 0.136654217 1.53293775 0.59651069 cg27087809 ACSBG1 23205 -3.03242 0.002671334 0.136654217 0.65760255 0.59968737 cgl6405957 KRT2A 3849 -3.03219 0.002673246 0.136654217 0.6536188 0.58183743 cg20764656 GPX2 2877 3.03204 0.002674591 0.136654217 1.52659576 0.59620815 cg02175308 SORT1 6272 3.03143 0.002679785 0.136654217 1.52250526 0.60704921
cgl2086773 C2orf25 27249 3.03036 0.002688933 0.136756065 1.50536759 0.6074526 cg24528447 NR2F1 7025 3.02952 0.002696235 0.136763696 1.52356138 0.60321702 cgl5378655 TSPYL4 23270 3.02842 0.002705687 0.136880065 1.54371367 0.59151876 cg00792740 UBE3A 7337 3.02579 0.00272854 0.136955816 1.50482069 0.60120008 cg09867835 GLP1R 2740 3.02569 0.002729412 0.136955816 1.52522475 0.60165389 eg 11566244 GSTP1 2950 3.02523 0.002733361 0.136955816 1.51304223 0.5980234 eg 11804789 CST7 8530 3.02414 0.002742914 0.136955816 1.52565185 0.59565349 cg25070637 SDC2 6383 3.02413 0.002742994 0.136955816 1.51552108 0.62424365 cg25712380 GRAP2 9402 -3.02106 0.002769995 0.137371353 0.64954317 0.6085115 cg24207176 ABCG2 9429 3.02044 0.002775465 0.137371353 1.52431671 0.5935357 cg04297093 KRTAP19-3 337970 -3.02034 0.002776355 0.137371353 0.6611703 0.58960266 eg 16509569 HEM 1 3071 3.01993 0.002780051 0.137371353 1.51621472 0.60392295 cg09358725 LM02 4005 3.01811 0.002796223 0.13781436 1.52090406 0.59282977 cg21223353 ANGPTL7 10218 -3.01522 0.002822044 0.138729423 0.65888671 0.60684752 cgl3336167 ZNF579 163033 3.01389 0.002834065 0.138963131 1.51857396 0.6023094 cg24197445 FU23049 79740 -3.01253 0.002846346 0.139208352 0.6569712 0.60235982 cgl0864501 POLDIP3 84271 3.01028 0.002866747 0.139848485 1.51057707 0.6031666 cgl l595245 HELLS 3070 3.00905 0.002877973 0.139926731 1.52276679 0.59338443 cg08880153 MAP1A 4130 -3.00851 0.002882986 0.139926731 0.66676566 0.60513312 cg25466368 HES1 3280 3.00608 0.002905297 0.140116764 1.54477625 0.60306575 cg08002996 SOCS2 8835 3.00535 0.002912019 0.140116764 1.50955525 0.60276321 cg20315951 OVOL1 5017 3.0052 0.002913392 0.140116764 1.52588015 0.58672852 cgl2783573 C6orfll3 221302 3.00428 0.002921988 0.140116764 1.51195844 0.60321702 eg 10485472 TMEM68 137695 3.00411 0.002923537 0.140116764 1.48740373 0.61375555 cg03586029 MGC33302 256471 3.00212 0.002942064 0.140387734 1.48612685 0.61657927 cg20583316 SERPINE1 5054 3.00192 0.002943956 0.140387734 1.50817304 0.59378782 cg08263647 LXN 56925 3.00114 0.002951215 0.140387734 1.50697239 0.60170432 cg05004940 C20orfl95 79025 3.00023 0.002959768 0.140445257 1.50589137 0.58022388 eg 16509658 GABRB2 2561 2.9985 0.002976067 0.140616157 1.51834091 0.60397338 cg01598642 HBG1 3047 -2.99828 0.002978076 0.140616157 0.66252418 0.6014522 eg 10266490 ACOT11 26027 2.99535 0.003005931 0.141404745 1.51320701 0.60795684 cg03959079 TAB3 257397 -2.99496 0.003009567 0.141404745 0.66486875 0.6012505 cgl2733079 ZNF277 11179 2.99321 0.003026334 0.141517858 1.51596877 0.58400565 cgl3943564 SERPINB2 5055 -2.99206 0.003037402 0.141517858 0.66832504 0.60518354 cg20637307 ERBB4 2066 2.99177 0.003040139 0.141517858 1.50066954 0.60417507 cgl5952725 ELA2A 63036 -2.99162 0.003041576 0.141517858 0.66393695 0.60301533 cg24073022 TAL2 6887 -2.98853 0.003071458 0.141947616 0.65292796 0.61178903 cgl0895130 BNIPL 149428 -2.98817 0.00307497 0.141947616 0.65051846 0.60135135 cg27510871 C9orf43 257169 2.9878 0.003078558 0.141947616 1.50974581 0.61763816 cg03283421 CUZD1 50624 -2.98667 0.003089557 0.141947616 0.65288457 0.60346914 cgl8741962 TRIM23 373 2.98564 0.003099701 0.141947616 1.51711385 0.60694837 cg02162950 KIAA1008 22894 2.98525 0.00310347 0.141947616 1.52357433 0.60800726
cgl0683939 C16orf47 388289 -2.98456 0.003110221 0.141947616 0.65202038 0.58909843 cgl l639651 H DC1 80201 -2.98454 0.003110466 0.141947616 0.66570493 0.59822509 cgl8699916 EGFL8 80864 -2.98381 0.003117619 0.141947616 0.65643057 0.60654498 cg24022301 PTGFR 5737 2.98213 0.003134209 0.142183863 1.50909225 0.61007463 cg04761824 Dec-01 50514 -2.97947 0.003160675 0.142183863 0.6535443 0.59288019 cg23412777 PYGOl 26108 -2.97933 0.003162 0.142183863 0.65190764 0.59938483 cg22232859 HIATL1 84641 -2.97912 0.003164098 0.142183863 0.64468858 0.59807382 cg21991396 CIAS1 114548 2.97894 0.003165921 0.142183863 1.50568389 0.58574526 eg 14372520 EDA2R 60401 -2.97879 0.003167419 0.142183863 0.66095428 0.59419121 cgl2802819 PUS3 83480 2.97728 0.00318258 0.142529869 1.52186698 0.61062929 cg01917648 SPIC 121599 -2.97606 0.003194826 0.142743983 0.65586839 0.60588947 eg 18704047 PARTI 25859 -2.97531 0.003202368 0.142747461 0.66508257 0.60447761 cg22853986 TRMT12 55039 2.972 0.003235948 0.143848166 1.5191408 0.58531666 cgl5523238 ATP 1 OA 57194 2.9714 0.003242106 0.143848166 1.50063538 0.59983865 cgl5495837 TRIM43 129868 -2.96912 0.003265432 0.144547725 0.66088295 0.60160347 cgl0762615 FBXWIO 10517 -2.96743 0.003282808 0.144732823 0.6595557 0.58874546 cgl3549845 GRID2 2895 2.96724 0.00328475 0.144732823 1.53471772 0.60997378 cgl0660256 BHMT 635 2.9659 0.00329864 0.145010696 1.48805349 0.58284591 cgl3296563 RPL6 6128 2.9647 0.00331113 0.145225934 1.50908206 0.59116579 cg04556854 FU35630 166379 2.96239 0.003335244 0.145877723 1.50608249 0.59242638 cg24408199 EIF2B5 8893 2.96181 0.003341248 0.145877723 1.49919567 0.60029246 cg24926276 LRG1 116844 2.95957 0.003364911 0.146576207 1.5106061 0.60069585 cgl5779381 PFAAP5 10443 2.9587 0.003374032 0.146639478 1.51370245 0.60044373 cg07136421 GPR89A 51463 -2.95697 0.003392411 0.146876995 0.65807061 0.5901069 cg26414731 PSMF1 9491 -2.95674 0.003394858 0.146876995 0.66680109 0.6074526 cg26804057 P0P1 10940 -2.95578 0.003405156 0.146947254 0.65441717 0.59620815 cg03817621 ACF 29974 -2.95515 0.003411851 0.146947254 0.6765344 0.60939391 cg04298323 PDE6C 5146 -2.95306 0.003434295 0.147425759 0.66872736 0.59943526 cg03370542 ATG4C 84938 2.9517 0.003448952 0.147425759 1.52228255 0.59998992 eg 14592099 PCDHB13 56123 2.95134 0.003452825 0.147425759 1.51287533 0.59676281 cgl l769360 LRAP 64167 -2.95068 0.003459978 0.147425759 0.66823775 0.60281364 cg00187686 TCN1 6947 2.95054 0.003461508 0.147425759 1.52513319 0.58935055 cg06692050 SFRP5 6425 -2.94945 0.003473354 0.14760156 0.66604818 0.60029246 cg26803566 SGPP1 81537 2.94817 0.003487261 0.14786396 1.48645683 0.59570391 cgl2360736 MBNL1 4154 2.94699 0.003500186 0.148083657 1.5075353 0.60931827 cg21094669 GLRA3 8001 2.94523 0.003519463 0.148570513 1.49928898 0.60946954 cg06822995 CAMK4 814 2.94426 0.00353013 0.148692562 1.46724467 0.59923356 cgl l756837 PRKAB1 5564 2.94302 0.003543826 0.148941374 1.48786258 0.59883017 cg21270593 PEG10 23089 -2.93891 0.003589591 0.150436871 0.6704422 0.60795684 cg23752985 VAMP8 8673 -2.93842 0.003595142 0.150436871 0.66541128 0.60432634 cg09473585 C3orfl4 57415 -2.93655 0.003616177 0.150596805 0.6525995 0.59615773 cg03794550 FANCF 2188 2.93554 0.003627596 0.150596805 1.50425882 0.60478015
cgl0652277 SLC30A9 10463 2.93537 0.003629446 0.150596805 1.49396755 0.58708148 cg00333528 GABRR1 2569 2.93488 0.003635102 0.150596805 1.49803967 0.60836023 cgl5538427 LOC221091 221091 2.93279 0.003658819 0.150596805 1.50094164 0.57966922 cg03649060 ELOF1 84337 -2.93221 0.003665475 0.150596805 0.66522182 0.58778741 eg 10240083 LOC92017 92017 -2.9315 0.003673593 0.150596805 0.66868711 0.59479629 cg03642518 PNOC 5368 2.93069 0.003682765 0.150596805 1.49519734 0.59101452 cg22215520 PAIP1 10605 -2.92994 0.003691431 0.150596805 0.66284781 0.59646027 cg02729352 ZNF432 9668 2.92585 0.003738756 0.150596805 1.49988396 0.59635942 cgl2869058 ABCA4 24 -2.92582 0.00373911 0.150596805 0.66729231 0.57810609 cg09414535 GRIP1 23426 -2.9257 0.003740511 0.150596805 0.66232344 0.6031666 cgl2018696 SFRS10 6434 2.92458 0.003753509 0.150596805 1.51482221 0.60599032 cgl8434152 PROK1 84432 -2.92446 0.003754947 0.150596805 0.67534023 0.59570391 cg25106814 C9orf82 79886 2.92384 0.003762153 0.150596805 1.48420537 0.59403994 cg27541515 ZNF235 9310 2.92377 0.003763029 0.150596805 1.48662565 0.59035902 cgl8790143 OTOS 150677 -2.92335 0.003767836 0.150596805 0.67398815 0.61012505 cgl7127769 LCP2 3937 2.92291 0.003773054 0.150596805 1.50300026 0.58768657 cg21119032 LANCL1 10314 2.92156 0.003788964 0.150596805 1.50226114 0.60049415 cg26870566 KIRREL 55243 -2.92076 0.003798386 0.150596805 0.66331248 0.59257765 cgl5459773 Clorfl24 83932 -2.91987 0.003808796 0.150596805 0.66682773 0.60709964 cg00027674 RAB38 23682 2.91848 0.003825286 0.150596805 1.48769528 0.58814038 cg09437522 GNAS 2778 2.91846 0.003825537 0.150596805 1.4951467 0.59590561 cg21008828 TNK2 10188 2.91784 0.003832904 0.150596805 1.47438855 0.59681323 cgl6834431 ATPIF1 93974 2.91772 0.003834415 0.150596805 1.51190857 0.59318274 cg23558650 PPME1 51400 2.91756 0.003836214 0.150596805 1.49167851 0.59051029 cg07586911 NYD-SP18 84691 -2.91743 0.003837806 0.150596805 0.67273029 0.59688887 cg02087637 PCDHB8 56128 2.91713 0.003841414 0.150596805 1.48749634 0.59988907 cg25743584 TIAF1 9220 -2.91662 0.003847415 0.150596805 0.67111948 0.5813332 cg09958090 KLHL22 84861 2.91656 0.003848165 0.150596805 1.47665921 0.61310004 cg21643045 CCL20 6364 -2.91626 0.003851796 0.150596805 0.67102893 0.59504841 eg 19404979 ELSPBP1 64100 -2.91582 0.00385707 0.150596805 0.67744452 0.5943929 cg26087862 ENSA 2029 -2.91567 0.003858846 0.150596805 0.67284929 0.60578862 cg02899723 DDX4 54514 -2.91321 0.003888427 0.151006209 0.66169395 0.58536708 cg03048535 FOXN4 121643 2.91177 0.003905819 0.151006209 1.47534268 0.60362041 cg01871995 FGL1 2267 -2.90999 0.003927313 0.151006209 0.66903451 0.59454417 eg 19306866 KRTAP6-2 337967 -2.9096 0.003932096 0.151006209 0.67430656 0.59464502 cgl4717170 SLITRK3 22865 2.90698 0.003964149 0.151006209 1.46966676 0.59701493 eg 14409083 EMP1 2012 2.90527 0.003985212 0.151006209 1.50389525 0.60775514 cg22980079 C4orf8 8603 -2.90372 0.004004321 0.151006209 0.66394213 0.58914885 eg 11649846 LOC346673 346673 -2.90295 0.004013805 0.151006209 0.66496661 0.60183038 cg01106788 KIAA1632 57724 -2.90269 0.004017061 0.151006209 0.66513975 0.60235982 cgl7333479 ZNF571 51276 2.90231 0.004021754 0.151006209 1.47944931 0.5841065 cgl9320612 SCN9A 6335 -2.89948 0.00405712 0.151006209 0.65735031 0.59998992
cg21919219 AMY1A 276 -2.89943 0.004057731 0.151006209 0.67315092 0.58324929 cg03329572 FCRL5 83416 -2.89929 0.004059467 0.151006209 0.67364557 0.59464502 cgl7479357 FU10803 55744 2.89781 0.004078138 0.151006209 1.53022358 0.59338443 cgl3121699 C2orfl0 91752 2.89736 0.004083802 0.151006209 1.49347978 0.60256152 cgl4058345 TXNDC6 347736 2.89685 0.004090161 0.151006209 1.47997185 0.60235982 cgl5019617 IFIT1 3434 2.89629 0.004097264 0.151006209 1.50400262 0.58521581 cgl2864903 FU46247 374786 -2.89606 0.0041002 0.151006209 0.66273971 0.59434248 cg00899659 ZNF22 7570 2.89559 0.004106133 0.151006209 1.5173785 0.60513312 cg27412093 CAPN9 10753 -2.89512 0.004112023 0.151006209 0.66725588 0.60377168 eg 11487967 FU41327 401045 -2.89398 0.004126593 0.151006209 0.66390189 0.58072812 cg04631202 MAN1C1 57134 2.89391 0.004127476 0.151006209 1.48667887 0.57977007 cgl2110626 FAM 18B2 201158 2.89335 0.004134609 0.151006209 1.48758361 0.58461073 cg08878352 PPP1R11 6992 2.8933 0.004135279 0.151006209 1.48508178 0.61113352 cg26709859 SYNJ2BP 55333 2.89248 0.004145733 0.151006209 1.4911898 0.59363655 cgl l812202 PNLIP 5406 -2.8922 0.004149257 0.151006209 0.66212167 0.59746874 cgl5262928 TIMM17A 10440 2.89087 0.004166269 0.151006209 1.46401653 0.60604074 cg25523753 ABHD2 11057 2.89049 0.004171256 0.151006209 1.48911129 0.59877975 cg04319097 ZFP161 7541 -2.89016 0.004175498 0.151006209 0.67440734 0.59676281 cg24648715 TCEAL3 85012 -2.88929 0.004186647 0.151006209 0.67243652 0.58072812 cg07204803 ARL13B 200894 -2.88895 0.00419102 0.151006209 0.67687237 0.58652683 cg24745738 EDNRB 1910 2.88888 0.004191944 0.151006209 1.51183212 0.59923356 cg06890553 ZNF223 7766 2.88825 0.00420007 0.151006209 1.49891346 0.5961073 cgl9298821 FU27505 389320 -2.88769 0.004207348 0.151006209 0.66526552 0.59318274 cg07703337 ZNF610 162963 -2.88634 0.004224843 0.151006209 0.67259489 0.59343485 cgl5772361 SERPINB3 6317 -2.88626 0.004225919 0.151006209 0.6646536 0.60251109 cg26180557 POU6F2 11281 -2.88612 0.004227766 0.151006209 0.67211327 0.58864462 cg21505886 TMEM129 92305 -2.88608 0.004228255 0.151006209 0.67775528 0.58940097 cg06625811 KIFAP3 22920 2.88552 0.004235559 0.151006209 1.48632497 0.59338443 cgl9192316 SIRT1 23411 -2.88508 0.00424122 0.151006209 0.67337653 0.57861033 cg27063986 NDST4 64579 -2.88497 0.004242711 0.151006209 0.67091105 0.58834207 cg03549127 GCA 25801 2.88491 0.004243478 0.151006209 1.4673023 0.59721662 cg08164315 PTGER4 5734 2.88481 0.004244842 0.151006209 1.4815907 0.59071198 cgl5005385 CCL3L1 6349 -2.88478 0.004245131 0.151006209 0.67453307 0.62192416 cgl l820734 MRPL35 51318 2.88471 0.004246143 0.151006209 1.48848364 0.59772086 cgl7277939 MGC13168 84821 -2.88345 0.004262608 0.151006209 0.66534673 0.58471158 cg23430634 C8orfl7 56988 -2.88315 0.004266563 0.151006209 0.67550604 0.59207342 cgl2686915 EIF3S3 8667 2.88314 0.0042667 0.151006209 1.51844093 0.58259379 eg 10368842 C10orf81 79949 -2.88262 0.004273514 0.151006209 0.66501634 0.5787616 cg00885506 WDR31 114987 2.88161 0.00428676 0.151006209 1.49237682 0.59963695 cg09058381 EAF1 85403 2.88136 0.004290085 0.151006209 1.47935351 0.58738403 cgl6601861 ALDH1A1 216 2.88118 0.004292383 0.151006209 1.47606603 0.61153691 cgl6970828 UBE1L 7318 2.88049 0.004301584 0.151006209 1.47150605 0.58829165
cg08056903 GPHN 10243 2.88037 0.004303162 0.151006209 1.49568833 0.61052844 cg22788223 NFYA 4800 2.88033 0.00430365 0. 151006209 1.46902679 0.60356999 cg00646492 GSTOl 9446 2.87848 0.004328145 0. 151587542 1.50539133 0.59434248 cg25866075 NALP12 91662 2.87716 0.004345723 0. 151833537 1.49756195 0.59161961 cg23074401 DDX10 1662 2.87581 0.004363758 0. 151833537 1.4750283 0.59701493 cg00410895 CCDC23 374969 -2.87547 0.004368384 0. 151833537 0.67020901 0.59376261 cgl9255783 PLAC8 51316 2.87512 0.00437301 0. 151833537 1.48782475 0.58846813 cgl5441973 HNMT 3176 -2.87498 0.004374868 0. 151833537 0.66672773 0.56686164 cg09085198 ANKRD29 147463 2.87258 0.004407311 0. 152519343 1.4835036 0.57260992 cg26540127 ACTR3 10096 2.87181 0.004417661 0. 152519343 1.48369832 0.59101452 cgl l921829 FCRL2 79368 2.87174 0.004418555 0. 152519343 1.49633377 0.58420734 cgl8876189 FGB 2244 -2.87012 0.004440558 0. 152952124 0.67832609 0.58385438 cg06324094 JTB 10899 2.86935 0.004451114 0. 152952124 1.49556563 0.59222469 cg00488718 MGC33302 256471 2.86906 0.004455088 0. 152952124 1.48068822 0.59489714 cg20023231 HS3ST2 9956 2.86751 0.00447621 0. 153401886 1.48946204 0.5945946 cg08474603 CRP 1401 -2.86692 0.004484286 0.15340371 0.68031188 0.59081283 cgl3216057 DKK3 27122 2.86473 0.00451455 0. 154021808 1.46736951 0.60740218 cgl4191360 MET 4233 2.86411 0.00452302 0. 154021808 1.50405785 0.60094796 cg04914105 PTPN9 5780 2.86386 0.004526517 0. 154021808 1.49022422 0.59444332 eg 11984608 CLDN16 10686 -2.86194 0.004553122 0. 154416666 0.67389734 0.6065954 cg27609819 PLCL1 5334 -2.86103 0.004565874 0. 154416666 0.67907415 0.60069585 cgl8180783 MY0Z1 58529 -2.86094 0.004567118 0. 154416666 0.67400329 0.5954518 cgl2791554 TAS2R49 259295 -2.8607 0.004570421 0. 154416666 0.67347303 0.58980436 cg27193335 EIF1B 10289 2.86008 0.004579102 0. 154437094 1.48778457 0.60599032 cg04660410 VILL 50853 2.85853 0.00460083 0. 154522368 1.4854287 0.57820694 cg24683061 PAIP2 51247 2.8583 0.004604118 0. 154522368 1.46819411 0.59585518 cg24267801 COX6C 1345 2.85586 0.004638522 0. 154522368 1.46681861 0.60321702 cgl4818279 SH3TC2 79628 -2.85425 0.004661392 0. 154522368 0.68131718 0.58607301 cgl9125606 AGT 183 -2.85261 0.004684737 0. 154522368 0.68577092 0.58965309 cgl8795395 GNG12 55970 2.85257 0.00468536 0. 154522368 1.4785503 0.60266236 cg00466436 DEFB126 81623 -2.85225 0.004689901 0. 154522368 0.66354246 0.60815853 cg03114244 FEN1 2237 2.8522 0.004690622 0. 154522368 1.47401965 0.5988806 cg21614638 DAPP1 27071 2.85201 0.004693286 0. 154522368 1.48456859 0.57815652 cg21770145 PCYT2 5833 -2.85112 0.004706023 0. 154522368 0.66785338 0.57729931 cg23479658 LIAS 11019 2.8509 0.004709205 0. 154522368 1.48429989 0.59020775 cgl5540820 EOMES 8320 2.84992 0.004723335 0. 154522368 1.47974117 0.58879589 cg25162921 MTAP 4507 2.84976 0.004725625 0. 154522368 1.48347221 0.59550222 cg07792737 NPIP 9284 -2.84968 0.004726783 0. 154522368 0.66584433 0.60261194 cgl2821045 ZNF573 126231 2.84943 0.004730338 0. 154522368 1.47308655 0.58254336 cg02863947 NR1I2 8856 2.84927 0.004732761 0. 154522368 1.47797095 0.59789734 cgl9968631 GLRA3 8001 2.84919 0.004733897 0. 154522368 1.49026368 0.58602259 cgl8432105 MYH2 4620 -2.84912 0.004734875 0. 154522368 0.6756022 0.60931827
cgl8013830 RPUSD2 27079 2.84848 0.004744121 0.154522368 1.47123528 0.58793869 cg21228284 TXNL4B 54957 2.8482 0.004748073 0.154522368 1.47889172 0.60407422 cg27610250 LOC91137 91137 2.84789 0.004752637 0.154522368 1.48657545 0.60301533 cgl4481339 KCNJ1 3758 -2.84742 0.0047594 0.154522368 0.67386377 0.60432634 cg00566759 DSC2 1824 2.84591 0.0047813 0.154569489 1.46894358 0.60725091 cg09699159 PRDM11 56981 -2.84552 0.004787015 0.154569489 0.67656026 0.6023094 cgl6753336 NPAS1 4861 2.84496 0.004795157 0.154569489 1.45973076 0.58012303 cg01835489 KRT8 3856 -2.84493 0.004795579 0.154569489 0.66583464 0.59756959 cgl l995303 DCUN1D5 84259 2.8441 0.004807824 0.154569489 1.46816426 0.60563735 cg21511069 UBAP2 55833 2.84366 0.004814208 0.154569489 1.49469213 0.58587132 cgl5754109 COPS5 10987 2.84256 0.004830373 0.154569489 1.48077415 0.58854377 cgl5942562 CDCA3 83461 -2.84253 0.004830734 0.154569489 0.67170647 0.58965309 cg09461185 PTGS2 5743 2.84155 0.004845243 0.154569489 1.47948669 0.57745059 cgl8356799 DSC1 1823 -2.84103 0.004852827 0.154569489 0.67535637 0.60780557 cgl3311440 CD48 962 2.83946 0.00487606 0.154569489 1.45563279 0.60987293 cg03532879 SMAF1 149685 -2.83928 0.004878704 0.154569489 0.67582322 0.60024203 cgl3098960 SOX15 6665 -2.83857 0.004889308 0.154569489 0.67777591 0.58461073 cgl0746737 HLA-DRB5 3127 -2.8383 0.004893353 0.154569489 0.67898914 0.59363655 cg25042226 PAX8 7849 2.83811 0.004896079 0.154569489 1.48353315 0.59227511 cg25536676 DHCR24 1718 2.83797 0.004898249 0.154569489 1.48425267 0.59827551 cg24408511 C12orf51 283450 -2.83763 0.004903214 0.154569489 0.67176901 0.57651775 cg04640886 C19orf30 284424 2.83741 0.004906521 0.154569489 1.47337575 0.57240823 cg06786424 PRPF4B 8899 2.8366 0.004918566 0.154569489 1.46917862 0.59817467 cgl5888522 XCR1 2829 -2.83597 0.004928036 0.154569489 0.6748873 0.58420734 cg25782229 WT1 7490 2.83483 0.004945079 0.154569489 1.48639722 0.59265329 cg05301852 FAB PI 2168 -2.83404 0.004957037 0.154569489 0.68511214 0.6014522 cg00384537 KRTHA5 3886 -2.83395 0.004958384 0.154569489 0.67323382 0.59363655 cg02275294 SOAT1 6646 2.83374 0.004961567 0.154569489 1.47867771 0.5997378 eg 11558474 TMEM2 23670 2.83362 0.004963343 0.154569489 1.48272038 0.57896329 cgl5946807 GADL1 339896 -2.83161 0.00499369 0.154569489 0.68109169 0.58935055 cg03973663 LYN 4067 2.83153 0.004994796 0.154569489 1.46850481 0.59656111 cgl7500329 C8orfl7 56988 -2.83112 0.005001047 0.154569489 0.6755015 0.58637556 cg04033774 GPSM2 29899 -2.83025 0.005014307 0.154569489 0.67070942 0.59646027 cgl8841894 S0D1 6647 2.83018 0.005015322 0.154569489 1.4664809 0.61340258 cg07086380 TNFAIP8 25816 -2.82991 0.005019402 0.154569489 0.6719729 0.60523397 eg 11489580 G3BP2 9908 2.82951 0.005025569 0.154569489 1.47335512 0.60029246 cg00275232 ZNF342 162979 2.82938 0.005027589 0.154569489 1.47032921 0.57689593 cgl4401837 GPR154 387129 -2.82762 0.005054472 0.154651986 0.68584959 0.59030859 cg00646140 ARSD 414 -2.82725 0.005060041 0.154651986 0.67878074 0.59030859 cg00112517 PPP1R1B 84152 -2.82703 0.005063512 0.154651986 0.67855209 0.58420734 cg04878842 ERCC2 2068 2.82673 0.005068037 0.154651986 1.46386004 0.60135135 cgl l262874 ZNF681 148213 -2.82656 0.005070708 0.154651986 0.67673714 0.5881908
cgl0917602 HSD3B7 80270 2.82582 0.005082076 0.154751858 1.46712352 0.5971662 cg08779777 PIK3CG 5294 2.82512 0.005092747 0.154830253 1.49061828 0.59333401 cg02499249 RARB 5915 2.8243 0.005105394 0.154930763 1.48328605 0.58909843 cg21142398 GLIS1 148979 -2.82326 0.005121613 0.154930763 0.67952985 0.59338443 cg05120715 UGCG 7357 2.82286 0.005127688 0.154930763 1.4583876 0.6181424 cg07122495 MLF1IP 79682 2.82281 0.00512846 0.154930763 1.48907117 0.58955224 cg04845063 FAM 13A1 10144 2.82085 0.005158956 0.155099031 1.45941391 0.60299012 cg01418124 ARHGAP24 83478 2.82013 0.005170289 0.155099031 1.50442005 0.60921743 cg07292816 EFCAB3 146779 -2.81995 0.005173091 0.155099031 0.67579834 0.57926583 cg24812523 AKAP6 9472 -2.81985 0.005174655 0.155099031 0.67575109 0.58435861 cg05032943 SFRS4 6429 2.8195 0.005180039 0.155099031 1.47301127 0.59872933 cgl5427774 G0RASP1 64689 2.81933 0.005182694 0.155099031 1.46551487 0.60624244 cgl4221831 CDH16 1014 -2.81804 0.005203006 0.155463605 0.68639994 0.57452602 cgl2237269 SLN 6588 -2.81748 0.005211842 0.155484698 0.67858794 0.60351956 cg27147004 PIWIL1 9271 -2.8158 0.00523839 0.155703323 0.67634789 0.59298104 cgl5248035 CCIN 881 2.81451 0.00525878 0.155703323 1.48488769 0.61062929 cgl8117847 ZNFN1A1 10320 -2.81406 0.005265915 0.155703323 0.68252411 0.59378782 cg25206802 SACS 26278 -2.81021 0.005327339 0.155703323 0.68528999 0.59161961 cgl4792155 PLA2G4E 123745 -2.81005 0.005330004 0.155703323 0.67840453 0.60856192 cg23740844 ATP5L 10632 2.80939 0.005340594 0.155703323 1.44804354 0.5995361 cg20867633 GOLT1A 127845 2.80842 0.005356207 0.155703323 1.45716049 0.59585518 cgl7771150 LCP1 3936 2.8071 0.005377581 0.155703323 1.46948976 0.58617386 cgl0002103 SLC38A2 54407 2.80649 0.00538746 0.155703323 1.46627197 0.60029246 cg07499806 ZSCAN5 79149 -2.80637 0.005389382 0.155703323 0.68419256 0.59383824 cgl7108383 PCDHGC5 56097 -2.80632 0.005390261 0.155703323 0.68240357 0.57977007 cg07376232 AMICA1 120425 2.80631 0.00539041 0.155703323 1.48328206 0.59746874 cg05159188 HIST1H4F 8361 2.80583 0.005398174 0.155703323 1.48140589 0.58687979 cgl6516400 FAM89A 375061 2.80558 0.005402221 0.155703323 1.47083192 0.58864462 cgl9910382 FAB PI 2168 -2.80519 0.005408492 0.155703323 0.67576516 0.5988806 cgl6377872 SLC1A6 6511 -2.80515 0.005409279 0.155703323 0.67721788 0.57603873 cg02973883 WDR21A 26094 -2.80486 0.005413952 0.155703323 0.67440042 0.58012303 cg01519742 JAKMIP1 152789 2.8045 0.005419796 0.155703323 1.45549281 0.59651069 cg01605783 LOC284837 284837 2.80447 0.005420284 0.155703323 1.46101718 0.58642598 cg08707078 MGC72075 340277 2.80399 0.005428119 0.155703323 1.48142358 0.59540137 cg08241785 F2RL2 2151 2.80384 0.005430509 0.155703323 1.48188708 0.59963695 cg26331192 GMNN 51053 2.80374 0.005432173 0.155703323 1.46186701 0.59580476 cgl5140807 FU31222 388387 -2.80342 0.005437524 0.155703323 0.67670925 0.61007463 cgl6558203 SLC22A14 9389 -2.80265 0.005450124 0.155703323 0.67095336 0.59494756 cg03690162 BAG 3 9531 2.80211 0.005458941 0.155703323 1.46440422 0.59378782 cg07947930 PRELP 5549 -2.80182 0.005463735 0.155703323 0.67720629 0.60024203 cg03570766 CATSPERl 117144 -2.80179 0.005464205 0.155703323 0.67223118 0.56852562 cgl l903096 PPP2R5C 5527 2.80154 0.005468209 0.155703323 1.49821238 0.6031666
cg04689061 PKIA 5569 2.80154 0.005468309 0.155703323 1.49322078 0.58758572 cg25623640 IGJ 3512 -2.80132 0.005471924 0.155703323 0.6825235 0.59343485 cg25769980 TLR6 10333 -2.80099 0.005477348 0.155703323 0.67365549 0.58597217 cgl6016036 TPO 7173 -2.8008 0.005480422 0.155703323 0.67066385 0.59091368 cgl9205041 PHACTR2 9749 -2.80021 0.005490154 0.155703323 0.67331538 0.59666196 eg 14696870 FCER1A 2205 -2.79986 0.005496007 0.155703323 0.66927873 0.57866075 cg02782630 FU13614 84142 2.799 0.00551019 0.155733434 1.44950589 0.58985478 cg09230646 FU20718 55027 -2.79731 0.005538267 0.155733434 0.67332668 0.58254336 cgl7186163 ClOorflO 11067 2.79699 0.00554351 0.155733434 1.46596738 0.57190399 cg03777459 GATA5 140628 2.79681 0.005546561 0.155733434 1.47137628 0.59877975 cg22161476 FSTL5 56884 2.79596 0.005560717 0.155733434 1.48193981 0.59237596 cg00737514 TBC1D1 23216 2.79287 0.005612582 0.155733434 1.46003581 0.60498185 cg02377083 CCBP2 1238 -2.79255 0.00561786 0.155733434 0.67706152 0.58834207 cg01177524 NEDD9 4739 2.79235 0.005621307 0.155733434 1.46264334 0.59328358 cg07990489 NUP35 129401 2.79203 0.005626756 0.155733434 1.47194907 0.59797297 cg27250927 HPS5 11234 2.79168 0.005632544 0.155733434 1.45714506 0.60155305 cgl2629083 SENP1 29843 2.79161 0.005633734 0.155733434 1.45407578 0.58531666 cg21652958 THBS2 7058 2.79147 0.005636102 0.155733434 1.47523885 0.58919927 cg01356829 IL12RB2 3595 2.7913 0.005639042 0.155733434 1.46841326 0.60457846 cgl0078415 ACSM3 6296 2.79124 0.005639977 0.155733434 1.48174333 0.59746874 cg l6418329 NYD-SP26 85438 -2.79117 0.005641159 0.155733434 0.68426575 0.59358612 cg25385272 TAFIA 9015 2.79068 0.005649461 0.155733434 1.46178117 0.57840863 cg06185738 SLC17A6 57084 2.79016 0.00565825 0.155733434 1.45920886 0.61138564 cgl0056627 GNMT 27232 2.78997 0.00566152 0.155733434 1.44905583 0.58466115 cg21165909 CPS1 1373 -2.78883 0.005680872 0.155733434 0.68300445 0.59595603 cg06403553 PGK2 5232 -2.78878 0.005681766 0.155733434 0.68479941 0.58284591 cgl7647273 UPB1 51733 -2.78877 0.005681876 0.155733434 0.68737678 0.5881908 cg04732193 HSDllBl 3290 -2.78732 0.005706676 0.155733434 0.67800994 0.58844292 cgl8534872 ZWINT 11130 2.78698 0.005712423 0.155733434 1.46359559 0.58965309 eg 19994834 GRIA3 2892 2.78639 0.005722538 0.155733434 1.46298366 0.59832594 cgl3721560 LRPPRC 10128 2.78639 0.005722606 0.155733434 1.46729405 0.5866781 cg05969697 BICD2 23299 2.78605 0.005728371 0.155733434 1.45063732 0.59484671 cgl7260725 CC B2 9133 2.78595 0.005730211 0.155733434 1.47969404 0.58940097 cg23538854 IL7 3574 2.7855 0.005737907 0.155733434 1.46242888 0.59943526 cg04087608 HSD3B2 3284 -2.78544 0.005738971 0.155733434 0.68183001 0.59595603 eg 11609344 YKT6 10652 2.7853 0.005741384 0.155733434 1.46933242 0.60341872 cg25533774 SOSTDCl 25928 2.78459 0.00575359 0.155843469 1.47516234 0.57724889 cg21094154 TNFSF11 8600 -2.78338 0.005774448 0.156067241 0.67970126 0.59378782 cg23455614 MRPS30 10884 2.78316 0.005778174 0.156067241 1.47427627 0.57719847 cgl0537079 OTC 5009 -2.78249 0.005789864 0.156162418 0.6850984 0.58778741 eg 16474696 MGC3207 84245 -2.78037 0.005826527 0.156724092 0.68560962 0.57740016 cgl9928247 TCEAL1 9338 2.78019 0.005829715 0.156724092 1.45624891 0.60220855
cgl9236745 CSTF3 1479 2.77987 0.005835275 0.156724092 1.47781032 0.60674667 cg08552121 TMEM14B 81853 2.7767 0.005890863 0.157995175 1.47496125 0.5858209 cg08008403 LHX9 56956 2.77604 0.005902525 0.158086237 1.46432999 0.59570391 cg06616147 ICK 22858 2.77484 0.005923608 0.158139398 1.45392515 0.5899052 cg24345247 HIST1H4A 8359 2.77474 0.005925489 0.158139398 1.47149108 0.59192215 cg05261824 ZNF165 7718 -2.77413 0.005936139 0.158139398 0.68232081 0.56983663 cg25461934 PROCR 10544 -2.77405 0.005937589 0.158139398 0.6662373 0.57946753 cg23352695 EVI2A 2123 2.77219 0.005970592 0.158757012 1.4707431 0.60548608 cg08463061 RND3 390 2.77181 0.005977382 0.158757012 1.46684718 0.59005647 cgl0194829 FGF17 8822 2.77052 0.006000423 0.158914524 1.46115129 0.58345099 eg 14209870 TAS2R5 54429 -2.77023 0.006005671 0.158914524 0.67884118 0.59822509 cg05251000 FREQ 23413 -2.76939 0.006020796 0.158914524 0.68364461 0.58642598 cg01868128 LCE5A 254910 -2.76909 0.006026064 0.158914524 0.68576815 0.5830476 cgl l631275 SDAD1 55153 -2.76872 0.006032777 0.158914524 0.68320953 0.57276119 cg07153965 ACRV1 56 -2.76845 0.006037631 0.158914524 0.67483647 0.59736789 eg 17260449 TOPBP1 11073 2.76753 0.006054196 0.158914524 1.44652672 0.58229125 cg26702254 KCND2 3751 2.76742 0.006056075 0.158914524 1.47476219 0.60478015 cg03140978 Clotf201 90529 -2.76731 0.006058104 0.158914524 0.67855974 0.60785599 cg21263196 BCAM 4059 2.76636 0.006075236 0.158927534 1.46835046 0.6012505 cg08099701 GABRA5 2558 -2.76609 0.006080151 0.158927534 0.68800267 0.58143405 cg02641676 SLC20A2 6575 -2.76573 0.006086683 0.158927534 0.67860163 0.58501412 cg20267005 TYRO BP 7305 2.76516 0.006097043 0.158927534 1.46323466 0.57578661 cg04473302 SLC26A4 5172 2.76486 0.006102571 0.158927534 1.45728614 0.59580476 cgl5287183 PPP1R9A 55607 2.76422 0.00611414 0.158927534 1.46085689 0.58103066 cg04106190 WNT16 51384 -2.76383 0.006121171 0.158927534 0.68766571 0.57977007 cg24818418 EGF 1950 -2.76362 0.006125087 0.158927534 0.68781166 0.60846107 cgl7638468 CD200R1 131450 2.76245 0.006146328 0.159242271 1.46674339 0.58173659 cg09303642 NFE2 4778 2.76204 0.006153871 0.159242271 1.46296142 0.58909843 cg24110050 TCTEXIDI 200132 2.76001 0.006191228 0.159853708 1.46069197 0.58995563 cg08839620 POLD3 10714 2.75863 0.00621666 0.159853708 1.43611953 0.58698064 cg21434954 LCE1B 353132 -2.7582 0.006224497 0.159853708 0.68489041 0.58798911 cgl0957680 G1P3 2537 2.75798 0.006228531 0.159853708 1.48023061 0.58461073 cg22268164 TRHR 7201 -2.75759 0.006235826 0.159853708 0.68086687 0.58077854 cg07117700 PSMC5 5705 -2.75746 0.006238277 0.159853708 0.68147572 0.57351755 cgl8555555 FABP7 2173 -2.75664 0.006253518 0.159853708 0.68638109 0.59736789 cg01283289 FU21963 79611 2.75662 0.006253743 0.159853708 1.4371363 0.6059399 cg22931889 TUBB1 81027 -2.75634 0.006259047 0.159853708 0.67845289 0.59484671 cgl8665563 HMGB3 3149 -2.75623 0.006261093 0.159853708 0.68779739 0.57861033 cg21299958 ITM2C 81618 2.75488 0.006286164 0.160189917 1.47212795 0.57740016 cgl8701598 LI PA 3988 2.75462 0.006291015 0.160189917 1.44344548 0.6023094 cg09161592 PANK1 53354 2.75342 0.006313453 0.160211416 1.46968032 0.58808996 cgl7503750 KRTAP19-6 337973 -2.75256 0.006329729 0.160211416 0.6860459 0.59373739
cg05125838 UCN2 90226 -2.75208 0.006338692 0.160211416 0.68479167 0.60866277 cg23187653 PCSK1 5122 2.75195 0.006341014 0.160211416 1.4562803 0.59746874 cgl5299463 TEAD2 8463 2.75159 0.006347846 0.160211416 1.44474063 0.60195643 cg21519900 C20orfl86 149954 -2.75001 0.006377726 0.160211416 0.68433213 0.60190601 cgl6518291 ZNF272 10794 2.74987 0.006380357 0.160211416 1.44581474 0.59464502 cgl7466535 TMEM55B 90809 2.74984 0.006380903 0.160211416 1.43280487 0.59898144 eg 14704941 CSRP3 8048 -2.74963 0.006384783 0.160211416 0.68266002 0.58778741 cgl8858343 UNC5B 219699 2.74939 0.006389341 0.160211416 1.45570262 0.59580476 cgl9114595 DIRAS3 9077 -2.7489 0.006398631 0.160211416 0.68937388 0.58340057 cg00481227 CTNNBL1 56259 2.74885 0.006399609 0.160211416 1.44785704 0.60301533 cg21625881 GNAS 2778 2.74879 0.006400773 0.160211416 1.46641853 0.60730133 cg24852661 GOLPH2 51280 2.74691 0.006436477 0.160894498 1.46116456 0.60578862 cgl0994126 PAPPA2 60676 -2.74592 0.006455371 0.161156139 0.69060058 0.59293062 cg01430430 FU37078 222183 -2.74548 0.006463821 0.161156709 0.69053298 0.58808996 cgl5992730 GDF3 9573 2.74481 0.006476634 0.161265904 1.45667549 0.58687979 cgl ll59727 MTERF 7978 2.74426 0.006487187 0.16131862 1.45938544 0.58844292 cg07373172 IFNA21 3452 -2.743 0.00651141 0.161342372 0.66202738 0.58284591 cg00354258 ZIM2 23619 2.74287 0.006513879 0.161342372 1.4536839 0.59474587 cg03033367 CSAG2 9598 -2.74254 0.006520332 0.161342372 0.67523065 0.57503025 cgl6923271 POLD1 5424 2.74243 0.006522459 0.161342372 1.46440674 0.58788826 cg07728874 CD3D 915 -2.74202 0.006530328 0.161342372 0.6889434 0.59857806 cgl2757143 C9orfll2 92715 -2.74094 0.006551211 0.161649463 0.69254381 0.58314845 cgl8752854 TNS1 7145 -2.74015 0.006566579 0.161819863 0.69169567 0.60175474 cg21968580 DNAJB4 11080 2.73933 0.006582555 0.16200479 1.44727719 0.58627471 cg06353720 IFIT3 3437 2.73766 0.006615072 0.162024334 1.47483461 0.57477814 cgl5609321 ZNF512 84450 2.73755 0.006617157 0.162024334 1.47464284 0.58945139 cg21250978 PRKAR2B 5577 -2.73748 0.006618581 0.162024334 0.68405026 0.589048 cg26680127 MLCK 91807 2.73744 0.006619273 0.162024334 1.46776255 0.60054457 cg04164824 SIGLEC9 27180 2.73711 0.006625713 0.162024334 1.45805098 0.58445946 cg01722994 GRIN2A 2903 2.73567 0.006654105 0.162138041 1.43464091 0.59787213 cg23242898 DCC 1630 2.73486 0.006669886 0.162138041 1.46879517 0.60044373 cgl0318351 GNL3L 54552 -2.73416 0.006683723 0.162138041 0.69208825 0.59167003 cg23613030 GPR115 221393 -2.73338 0.006699112 0.162138041 0.68347342 0.5875353 cg21438018 MSH4 4438 -2.73334 0.006699882 0.162138041 0.68690285 0.59242638 cg07633499 UFD1L 7353 2.73304 0.006705838 0.162138041 1.46319824 0.6059399 cg25463779 FAM 101A 144347 -2.73219 0.006722609 0.162138041 0.68254417 0.58909843 cg08404225 IL5RA 3568 -2.73068 0.00675279 0.162138041 0.68953722 0.59580476 cg02217814 LOC93343 93343 2.73052 0.006755878 0.162138041 1.4434936 0.59217426 cg07639959 EXOl 9156 2.73038 0.006758743 0.162138041 1.44374514 0.58657725 cg25427580 B3GALT1 8708 -2.73004 0.006765542 0.162138041 0.69057864 0.58007261 cgl9324172 PPID 5481 2.72972 0.0067719 0.162138041 1.4477219 0.6059399 cgl l024597 ECRG4 84417 2.72956 0.006775059 0.162138041 1.46873429 0.61057886
cg22313025 HACE1 57531 2.72939 0.006778351 0.162138041 1.44754013 0.57578661 0 0 0 0 0 cg03890877 PT 9L 11344 2.72916 0.006783007 0. 162138041 1 .46339808 0 .59560307 0 0 0 0 0 cg01804844 SDCCAG33 10194 -2.7286 0.006794196 0. 162138041 0 .68486986 0 .58587132 0 0 0 0 0 cg05343453 LOC136263 136263 -2.72812 0.006803868 0. 162138041 0 .67727379 0 .58824123 0 0 0 0 0 cg24231716 OTP 23440 2.72771 0.006812119 0. 162138041 1 .45685279 0 .59751916 1 0 0 0 1 cg20318748 NANP 140838 -2.72682 0.006829851 0. 162138041 0 .69480322 0 .59656111 0 0 0 0 0 eg 14444244 FU13096 80067 -2.72564 0.006853708 0. 162138041 0 .67406179 0 .59429205 0 0 0 0 0 cg08983259 INSL5 10022 -2.72491 0.006868383 0. 162138041 0 .68701829 0 .59111537 0 0 0 0 0 cg21460582 CSPG4 1464 -2.72486 0.006869551 0. 162138041 0 .68425907 0 .58713191 0 0 0 0 0 cg03985136 ULBP2 80328 2.72475 0.006871645 0. 162138041 1 .43212979 0 .59449375 1 0 0 0 0 cgl7356252 AIRE 326 2.72446 0.006877639 0. 162138041 1 .44988206 0 .60528439 0 0 0 0 0 cgl7022914 BATF2 116071 2.7228 0.006911245 0. 162138041 1 .44600436 0 .58430819 0 1 0 0 0 cgl7474651 MAGEC3 139081 -2.72271 0.006913024 0. 162138041 0 .69004065 0 .58975393 0 0 0 0 0 cg26864061 SACM1L 22908 2.72261 0.006915114 0. 162138041 1 .43876545 0 .58340057 0 0 0 0 0 cg24546942 SERPINB4 6318 -2.72233 0.006920781 0. 162138041 0.69104 0 .60881404 0 0 0 0 0 cgl5767406 ZNF660 285349 2.72215 0.006924435 0. 162138041 1 .44375703 0 .59449375 0 0 0 0 0 cg27611781 PDXP 57026 2.72205 0.006926507 0. 162138041 1 .45947487 0 .56817265 0 0 0 0 0 cg04183425 ASF1A 25842 -2.72133 0.006941164 0. 162138041 0 .68521617 0 .58435861 0 0 0 0 0 cg24992780 OR7C1 26664 -2.72053 0.006957584 0. 162138041 0 .69385594 0 .58854377 0 0 0 0 0 cg00615377 RBM9 23543 2.71903 0.00698832 0. 162138041 1 .46643036 0 .59479629 0 0 0 1 0 cgl3120814 FU11000 55281 2.71881 0.006992748 0. 162138041 1 .44745671 0 .57795482 0 1 0 0 0 cgl9817399 CYP1A1 1543 2.71854 0.006998304 0. 162138041 1 .45637942 0 .59555264 0 0 0 0 0 cg09398185 IFIT2 3433 2.71816 0.007006191 0. 162138041 1 .46562076 0 .59293062 0 0 0 0 0 cg01033938 ADAMTS8 11095 2.71804 0.007008641 0. 162138041 1 .44678233 0 .60160347 0 0 0 0 0 cgl4188232 ITGA11 22801 2.71793 0.007010756 0. 162138041 1 .44569252 0 .57306374 1 0 0 0 0 cgl9863003 REEP5 7905 2.71768 0.007015956 0. 162138041 1 .43997611 0 .59202299 0 0 0 0 0 cg20542800 LTB4R 1241 2.71751 0.007019578 0. 162138041 1 .46399596 0 .58935055 0 0 0 0 0 cg25889160 SERPINA5 5104 -2.71735 0.007022868 0. 162138041 0 .68399152 0 .57871117 0 0 0 0 0 cgl6275172 TM0D3 29766 2.71732 0.007023478 0. 162138041 1 .45857548 0 .58042558 0 0 0 0 0 cgl3253729 Rgr 266747 -2.7169 0.007031993 0. 162138041 0 .68932124 0 .57835821 0 0 0 0 0 cg20217872 NAV3 89795 2.71665 0.007037242 0. 162138041 1 .46569826 0 .57694635 0 0 0 0 1 cg23927367 ACAD8 27034 2.71653 0.007039693 0. 162138041 1 .46078542 0 .60220855 0 0 0 0 0 cg09340639 FCRL1 115350 2.71594 0.007052037 0. 162138041 1 .46403646 0 .59530052 0 0 0 0 0 cg26759925 IL1F9 56300 -2.71527 0.00706582 0. 162138041 0 .69380533 0 .58491327 0 0 0 0 0 cg20831492 BET1 10282 2.71522 0.007066879 0. 162138041 1 .45161707 0 .58768657 0 0 0 0 0 cgl5083227 PLEKHQ1 80301 2.71507 0.007070014 0. 162138041 1 .43107107 0 .59293062 0 0 0 0 0 cg23087084 PXMP3 5828 2.71496 0.007072335 0. 162138041 1 .47423706 0 .59348528 0 0 0 1 0 cgl l695601 CHN1 1123 2.71474 0.007076805 0. 162138041 1 .46678469 0 .59903187 0 0 0 0 1 eg 11688469 TNNI1 7135 -2.71448 0.007082195 0. 162138041 0 .68566238 0 .59323316 0 0 0 0 0 eg 19046959 COL8A2 1296 2.71412 0.007089631 0. 162138041 1 .43727553 0 .57785397 0 0 0 0 0 cgl8023080 MASP2 10747 -2.71409 0.007090368 0. 162138041 0 .69110525 0 .59509883 0 0 0 0 0 cg05059825 TTC9C 283237 2.71378 0.007096692 0. 162138041 1.4382129 0 .57664381 0 0 0 0 0
cgl6359129 Clorflll 284680 -2.71293 0.007114532 0.162351661 0.6835826 0.60614159 cg08625022 0STF1 26578 2.7125 0.007123404 0.162360369 1.45334488 0.60356999 cg08510456 BSN 8927 2.71201 0.007133679 0.162401001 1.46124435 0.5839048 eg 14386061 DOK2 9046 2.71081 0.007158843 0.162579349 1.47422658 0.58456031 cg22122449 ACR 49 -2.71047 0.007166051 0.162579349 0.68691493 0.58940097 cg07285953 CRYBA1 1411 -2.70977 0.00718074 0.162579349 0.68575642 0.58849334 cg05828624 REG1A 5967 -2.70962 0.007183929 0.162579349 0.67876494 0.59403994 cgl7502536 PADI1 29943 -2.70961 0.007184023 0.162579349 0.68193373 0.58188786 cg09632136 NNMT 4837 -2.70845 0.007208582 0.162735929 0.68665403 0.59061113 cg06415153 PITPNM2 57605 2.70833 0.00721117 0.162735929 1.46575304 0.58143405 cg24621354 TES 26136 2.70621 0.00725607 0.162735929 1.43135762 0.58975393 eg 14409958 ENPP2 5168 2.70616 0.007257132 0.162735929 1.45819876 0.58501412 cgl l819637 THPO 7066 -2.70577 0.007265394 0.162735929 0.68723488 0.58632513 eg 14606768 C9 735 -2.7057 0.007266894 0.162735929 0.67229504 0.584762 cgl4168975 ALAS2 212 -2.70517 0.007278059 0.162735929 0.69212262 0.5802743 eg 18408487 NT5C3L 115024 -2.70506 0.007280436 0.162735929 0.68779488 0.57583703 cg01618660 TRIM 14 9830 2.70502 0.0072813 0.162735929 1.43502962 0.58884631 cgl2520111 PPIA 5478 2.70453 0.007291808 0.162735929 1.44218205 0.58985478 cg21721865 UFM 1 51569 2.70372 0.007308942 0.162735929 1.46001299 0.59519968 cg08762247 TMEMIOO 55273 2.70283 0.007328115 0.162735929 1.45232154 0.59484671 cg07713493 PCTK3 5129 2.70243 0.00733671 0.162735929 1.45781081 0.57724889 cgl3349425 C5orf20 140947 -2.70219 0.00734187 0.162735929 0.68833473 0.59066156 cg24949049 TDRD3 81550 -2.702 0.007345922 0.162735929 0.6860694 0.6050827 cg23765993 SPINLWl 57119 -2.70158 0.007354989 0.162735929 0.68946824 0.58642598 cgl0324224 TTC13 79573 -2.70091 0.007369395 0.162735929 0.69467756 0.59640984 cg07892051 AKAP3 10566 -2.70053 0.007377453 0.162735929 0.67870373 0.58405607 cgl5056412 APBA2BP 63941 -2.70053 0.00737759 0.162735929 0.68965556 0.5717023 cgl l265916 MAPK1 5594 2.70022 0.007384215 0.162735929 1.45606491 0.58415692 cg20851245 RNF25 64320 -2.69983 0.007392721 0.162735929 0.68463694 0.59484671 cg21023114 IFNA14 3448 -2.69968 0.007395872 0.162735929 0.68755928 0.59101452 cg27462371 ATX 7 6314 2.69943 0.007401295 0.162735929 1.43050835 0.59656111 cg21416022 TTC23 64927 2.69941 0.007401657 0.162735929 1.44858453 0.5873336 cgl l655691 CBARA1 10367 2.69932 0.007403691 0.162735929 1.45860739 0.59378782 cg07347645 SYCP2 10388 -2.69852 0.007420927 0.162803529 0.68728237 0.58768657 cg02780988 KRTHA6 8689 -2.69832 0.007425426 0.162803529 0.6946185 0.58445946 cgl5997411 JAK1 3716 -2.698 0.007432307 0.162803529 0.68555823 0.59282977 cgl8357645 OS9 10956 2.69592 0.007477523 0.163294126 1.47169072 0.58443425 cgl5247144 PYCARD 29108 2.69588 0.007478451 0.163294126 1.43255972 0.57982049 cgl2531542 MOGAT2 80168 -2.69579 0.007480322 0.163294126 0.68386391 0.58577047 eg 10906663 PHEX 5251 -2.69427 0.00751354 0.163786639 0.68487062 0.58864462 cgl8379495 ZNF703 80139 2.69398 0.007520013 0.163786639 1.42641269 0.60311618 cg l7301902 GNA14 9630 2.69217 0.007559719 0.163870584 1.43267934 0.59998992
cg05754589 CBX5 23468 2.69187 0.007566511 0.163870584 1.44819658 0.59671238 eg 19784477 TFPI2 7980 2.69086 0.007588677 0.163870584 1.44550775 0.59484671 cg04984513 BRI3BP 140707 2.69076 0.007590841 0.163870584 1.48194601 0.58546793 cgl0741369 TRIM 7 81786 2.69075 0.00759127 0.163870584 1.45421658 0.58067769 cg25661781 WIPI1 55062 2.69067 0.007592946 0.163870584 1.45862519 0.59061113 cg04972979 C20orf54 113278 2.69066 0.007593078 0.163870584 1.43963021 0.60407422 eg 16004800 NDUFA9 4704 2.69034 0.007600307 0.163870584 1.4442651 0.57049213 cgl4091657 LHX3 8022 -2.69031 0.007600991 0.163870584 0.68840858 0.58012303 cg06212607 GGPS1 9453 2.68864 0.007637984 0.163984926 1.45031569 0.58758572 cg08319404 THRB 7068 2.68748 0.007663766 0.163984926 1.44732762 0.60301533 cgl3097407 CRIP3 401262 2.6871 0.007672347 0.163984926 1.44410919 0.60185559 cg22510822 OR1E2 8388 -2.68706 0.0076731 0.163984926 0.68280612 0.57205526 cgl l422541 ADCY6 112 2.68605 0.007695793 0.163984926 1.4339218 0.59625857 cgl2592779 ZNF12 7559 2.68589 0.007699447 0.163984926 1.44923174 0.59615773 cg26823505 CLPS 1208 -2.68581 0.007701234 0.163984926 0.68957555 0.57134933 cgl7500962 C16orf47 388289 -2.68522 0.007714424 0.163984926 0.69030522 0.58022388 cg03317245 P2RX5 5026 2.68513 0.007716324 0.163984926 1.43777293 0.59817467 cg23599056 ZMYND17 118490 -2.6849 0.007721694 0.163984926 0.68524304 0.56837434 cg23855566 FAM73A 374986 2.68456 0.007729184 0.163984926 1.43943661 0.59706535 eg 18489440 KIAA0746 23231 2.68427 0.0077357 0.163984926 1.45324749 0.57634127 cg23112213 CDC23 8697 2.68421 0.007737161 0.163984926 1.44734684 0.58914885 cg24399405 C16orf35 8131 2.68413 0.007738964 0.163984926 1.44479946 0.6012505 cg00063144 KRTHA1 3881 -2.68369 0.007748742 0.163984926 0.68869097 0.60427592 cg26366091 CHI3L2 1117 2.6834 0.007755377 0.163984926 1.44827385 0.59237596 cgl5602809 CHRM3 1131 2.68307 0.007762861 0.163984926 1.45156105 0.60957039 cg07278207 DCDC1 341019 2.68249 0.007775806 0.163984926 1.44792442 0.59827551 cg22780428 CEPT1 10390 2.68215 0.007783633 0.163984926 1.44521054 0.59681323 cg04956511 PTPN6 5777 2.68207 0.007785482 0.163984926 1.43447629 0.56091166 cg26682500 FU40919 144809 -2.68166 0.007794704 0.163984926 0.69067726 0.58208955 cg23004625 PIGM 93183 2.68158 0.007796405 0.163984926 1.45799448 0.60548608 cg25736482 TMC4 147798 2.68127 0.007803527 0.163984926 1.44799751 0.58335014 cgl5201291 CYP2C8 1558 -2.68083 0.007813609 0.164001653 0.68731297 0.56686164 cg24450631 IGF2BP2 10644 -2.67985 0.00783584 0.164001653 0.69211158 0.57392094 cg09536738 EFHD1 80303 2.67924 0.007849804 0.164001653 1.44989359 0.58622428 cg06366981 HPGD 3248 2.6782 0.007873396 0.164001653 1.42037063 0.58173659 cg23889010 SLPI 6590 2.67803 0.007877317 0.164001653 1.44584984 0.57331585 cgl6598810 DEPDC1 55635 2.678 0.007878004 0.164001653 1.44020881 0.6040238 cgl6177163 PTDSS1 9791 -2.67791 0.007879972 0.164001653 0.69833128 0.59368697 cg26767897 XDH 7498 -2.67744 0.007890935 0.164001653 0.68636062 0.58587132 cgl7281600 FCRL4 83417 -2.67732 0.007893535 0.164001653 0.69263901 0.59464502 cgl9556572 AKNA 80709 -2.67613 0.007920819 0.164001653 0.70196102 0.58188786 cg04095468 SECISBP2 79048 2.67576 0.007929341 0.164001653 1.44431287 0.60634328
cg08016363 TMEM11 8834 2.67575 0.007929606 0.164001653 1.47961061 0.58193828 eg 18409845 Mar-05 54708 2.67523 0.007941633 0.164001653 1.44468652 0.56625656 cgl l903057 RHOH 399 2.67515 0.007943361 0.164001653 1.47257719 0.59106495 cg25201363 LRPAP1 4043 2.67489 0.007949541 0.164001653 1.43689676 0.57987092 cg23801057 P2RX7 5027 -2.67479 0.007951677 0.164001653 0.69295771 0.58970351 cg00393585 FU31659 152756 2.67423 0.007964621 0.164001653 1.44076223 0.59424163 eg 11494699 RAG1 5896 -2.67388 0.007972819 0.164001653 0.68881997 0.59393909 cg23937047 PAG El 8712 -2.67376 0.007975667 0.164001653 0.68853959 0.58506454 cg05556202 TM4SF19 116211 -2.67314 0.007989971 0.164001653 0.69611029 0.5858209 cg24832140 ZNF114 163071 2.67285 0.007996613 0.164001653 1.45070972 0.5978217 cgl0523671 SLC15A2 6565 -2.67267 0.008000859 0.164001653 0.68699325 0.58718233 cgl5452426 DFFA 1676 2.67264 0.008001575 0.164001653 1.43911091 0.57059298 cg09459044 PPA2 27068 2.67208 0.008014414 0.164088928 1.45753975 0.61229326 cgl3859541 TGFBR2 7048 2.67111 0.008037028 0.164375948 1.44438526 0.58541751 cgl5841415 SLC1A3 6507 2.66931 0.008079185 0.164603687 1.45164219 0.58965309 cg24443367 SLC16A9 220963 -2.6689 0.008088693 0.164603687 0.69482279 0.578333 eg 17260124 KCTD14 65987 -2.6686 0.0080958 0.164603687 0.68488589 0.59383824 cg01909487 JUN 3725 -2.66834 0.008101739 0.164603687 0.69690577 0.59116579 cg09119967 C20orfl03 24141 2.66721 0.008128448 0.164603687 1.44491712 0.58768657 cgl3019092 PDZK1 5174 -2.66709 0.008131301 0.164603687 0.687989 0.58461073 cgl0215570 LOC84661 84661 2.66707 0.008131598 0.164603687 1.45512573 0.59025817 eg 14209569 COMMD4 54939 2.66621 0.008151891 0.164603687 1.43124845 0.59293062 cgl7248183 LOC162427 162427 2.666 0.008156813 0.164603687 1.43672632 0.57417305 cg07864297 ESRRB 2103 -2.66564 0.008165368 0.164603687 0.69521465 0.58849334 cgl3675849 TRPV5 56302 -2.66482 0.008184834 0.164603687 0.68672656 0.59177088 cg23309825 MLC1SA 140465 2.66463 0.008189388 0.164603687 1.43683697 0.58945139 cgl4074117 MGC35212 254528 -2.66462 0.008189506 0.164603687 0.69315431 0.60246067 cgl2966875 SLPI 6590 2.66444 0.008193726 0.164603687 1.46924864 0.58264421 cg09548179 AMDHD2 51005 -2.66443 0.008193983 0.164603687 0.68987064 0.59444332 eg 11406340 IDI2 91734 -2.66432 0.008196526 0.164603687 0.68433047 0.56774405 cgl8977436 FGF14 2259 2.66427 0.008197928 0.164603687 1.45261561 0.57205526 cgl5014458 LYPD3 27076 2.66403 0.008203618 0.164603687 1.42594603 0.59600645 cg22165507 MGST3 4259 2.66359 0.008214057 0.164603687 1.4314313 0.58879589 cg02276793 TLOC1 7095 2.66332 0.008220316 0.164603687 1.43889301 0.59519968 cg20383064 BFSP2 8419 -2.66276 0.008233612 0.164697454 0.68710988 0.56963493 cg01794711 CNDP2 55748 2.66172 0.008258415 0.164837003 1.43414061 0.5768455 cg02142461 LYAR 55646 2.66075 0.00828178 0.164837003 1.43855063 0.56413877 cgl4738823 C12orf46 121506 -2.6603 0.008292355 0.164837003 0.6925926 0.58113151 cgl3791713 HMGN1 3150 -2.66 0.008299707 0.164837003 0.68985145 0.58471158 cg00448720 MGC48915 338872 -2.65937 0.008314763 0.164837003 0.69072209 0.5691307 cg04683119 GUF1 60558 2.65925 0.00831764 0.164837003 1.45174203 0.584762 cg26591879 ATF6 22926 2.65908 0.008321721 0.164837003 1.44520554 0.5926785
cgl3294439 TA-PP2C 160760 2.65887 0.008326667 0.164837003 1.43775466 0.59938483 cg25371560 MED18 54797 2.65856 0.008334158 0.164837003 1.43022678 0.5875353 cg26232558 OR3A1 4994 -2.65771 0.008354631 0.164837003 0.69311904 0.58173659 cgl3983870 TSPAN12 23554 2.65755 0.00835858 0.164837003 1.43831493 0.59590561 cgl6001913 HK1 3098 -2.6574 0.008362239 0.164837003 0.70049084 0.58950182 cg20442709 Clorf9 51430 2.65738 0.008362726 0.164837003 1.44713932 0.60331787 cg27475152 BTN1A1 696 -2.65687 0.008374922 0.164837003 0.68270306 0.58945139 cgl7687282 A4GNT 51146 -2.65675 0.008377989 0.164837003 0.68598504 0.57624042 cg03752689 Clorf74 148304 2.65672 0.008378506 0.164837003 1.44198273 0.58859419 cg22464186 TNFRSF21 27242 -2.65626 0.008389635 0.164886316 0.69947651 0.5909641 cg08872493 HTR1D 3352 -2.65521 0.008415082 0.165191352 0.69306117 0.59461981 cg06698742 TMEM126A 84233 2.65472 0.008427151 0.165191352 1.44099058 0.60029246 cg01423840 FATE1 89885 -2.65456 0.008431071 0.165191352 0.6857885 0.59272892 cgl l891583 GLUD2 2747 -2.65335 0.00846052 0.165378008 0.67841171 0.57336628 cgl3281868 C6orfl42 90523 -2.6531 0.008466508 0.165378008 0.68753147 0.59131706 cgl2484193 DUSP19 142679 2.6531 0.008466542 0.165378008 1.44078379 0.59398951 cg03312792 SEMG2 6407 -2.65233 0.008485254 0.16545354 0.68830564 0.56923155 cg03554552 PPP1R13L 10848 2.65068 0.008525806 0.16545354 1.42893703 0.56882816 cg22001782 BCL9 607 2.6496 0.008552494 0.16545354 1.45003481 0.58450988 cg26449836 SSBP1 6742 2.64953 0.008554149 0.16545354 1.45197934 0.59126664 cgl0929387 ITIH4 3700 -2.64896 0.008568056 0.16545354 0.69730695 0.58788826 cg25124223 NUP43 348995 2.6489 0.008569697 0.16545354 1.44408648 0.59066156 cg04970352 ALX4 60529 2.64868 0.00857517 0.16545354 1.44355259 0.60220855 cg02936740 TMPRSSl lF 389208 -2.64852 0.008578984 0.16545354 0.69465429 0.59328358 cg08539991 ZBTB32 27033 -2.64832 0.008584011 0.16545354 0.69472284 0.60810811 cg09499849 ACVR1 90 2.64779 0.00859716 0.16545354 1.4535536 0.58400565 cgl2783776 SERPINGl 710 2.64686 0.008620021 0.16545354 1.45044734 0.59202299 cg24512303 HNF4G 3174 -2.64648 0.008629556 0.16545354 0.69392365 0.58687979 cg20870559 OAS2 4939 2.64628 0.008634432 0.16545354 1.43924329 0.58854377 cgl l745019 ANGPT1 284 2.64628 0.008634472 0.16545354 1.43872946 0.58380395 cg06177698 GABRQ 55879 -2.64617 0.008637227 0.16545354 0.69266877 0.59247681 cgl7177336 HSPC268 154791 2.64617 0.008637366 0.16545354 1.4405636 0.57714804 cg01172484 MAGEH1 28986 2.64583 0.008645676 0.16545354 1.42590047 0.57714804 cgl2799265 Clorf50 79078 2.64577 0.008647128 0.16545354 1.43457422 0.57830779 cg20939319 TEX15 56154 2.64574 0.008647882 0.16545354 1.43360265 0.58244252 cg00546491 PDE1C 5137 -2.64527 0.008659538 0.16545354 0.67828845 0.56797096 cgl8509239 IGSF10 285313 -2.6452 0.008661319 0.16545354 0.69062352 0.5954518 cgl5207619 CAB39L 81617 2.64511 0.008663567 0.16545354 1.44564127 0.59298104 eg 19754094 STAMBP 10617 2.64455 0.008677602 0.16545354 1.43937483 0.57926583 cgl2256080 ABT1 29777 2.64428 0.008684343 0.16545354 1.43270525 0.62141993 eg 10160407 PDGFRL 5157 2.64338 0.008706911 0.16545354 1.43114254 0.55642396 cg03976567 C6orfl99 221264 2.64336 0.008707284 0.16545354 1.44337654 0.59862848
cg27039606 PRODH2 58510 -2.64302 0.00871594 0.16545354 0.6870717 0.60548608 cg02065387 GABRA1 2554 2.64233 0.008733116 0.16545354 1.44283256 0.58637556 cg03118854 PNPLA5 150379 2.64232 0.00873344 0.16545354 1.41615313 0.58052642 cg09757277 ZNF222 7673 2.64198 0.008742036 0.16545354 1.47061506 0.58592174 cgl l481351 FNDC7 163479 -2.6416 0.008751504 0.16545354 0.68504054 0.58793869 cg03851112 BBS1 582 2.64122 0.008761167 0.16545354 1.43810913 0.59933441 cgl2263485 CBX5 23468 2.64117 0.008762249 0.16545354 1.45066226 0.58546793 cg08025786 CL 3 1198 -2.64105 0.008765298 0.16545354 0.68380285 0.5971662 eg 10585462 C4orf7 260436 -2.64074 0.008773232 0.16545354 0.69433836 0.58718233 cg21264329 DJ12208.2 57226 2.64016 0.008787685 0.165562834 1.4251463 0.60866277 cgl5317267 H19 283120 2.63908 0.008815024 0.165914442 1.43865607 0.57492941 cg01594915 HNRPA3 220988 2.63861 0.008826907 0.165974745 1.46262125 0.58566963 cgl3958304 RSBN1 54665 2.63648 0.008881112 0.166282876 1.43346952 0.57820694 cgl3314167 C9orf84 158401 -2.63603 0.00889266 0.166282876 0.69159262 0.58894716 cg01902747 CCDC7 221016 2.63588 0.008896291 0.166282876 1.44618764 0.59247681 cg01214321 DPYSL2 1808 2.63581 0.008898125 0.166282876 1.42886672 0.59827551 cg25500444 FU23514 60494 2.63573 0.008900305 0.166282876 1.41634373 0.6023094 cg26532905 RNASEL 6041 -2.63543 0.008907789 0.166282876 0.69744286 0.582619 cg02148642 RGPD5 84220 -2.63499 0.008919016 0.166282876 0.6940294 0.57765228 cg23776012 KA21 125113 2.63494 0.008920416 0.166282876 1.44424307 0.58365268 cgl5714041 ACOl 48 2.63429 0.008936973 0.166282876 1.43573731 0.60266236 cg04785227 CHRNA7 1139 2.63368 0.008952731 0.166282876 1.44169704 0.60281364 cg00687674 TMEM84 283673 2.63365 0.008953411 0.166282876 1.42940173 0.58017346 cg23773532 GPRC5D 55507 -2.63338 0.008960395 0.166282876 0.69244562 0.59479629 cg03242880 BTG4 54766 -2.63279 0.008975603 0.166282876 0.70040479 0.58420734 eg 10257049 C5orf4 10826 2.63258 0.008980865 0.166282876 1.41488283 0.58572005 cg07281640 C9orf6 54942 2.63233 0.008987494 0.166282876 1.42876449 0.58360226 cgl7563769 GTF2A2 2958 2.63225 0.008989412 0.166282876 1.44125105 0.58087939 cg21902544 CBLN2 147381 2.63177 0.009001969 0.166282876 1.43256408 0.61178903 cg22199080 CENTG1 116986 2.63044 0.009036189 0.166282876 1.44840967 0.58385438 cg07496861 LOC151194 151194 -2.63044 0.009036286 0.166282876 0.69836791 0.59429205 cg06418184 DCTN3 11258 2.63037 0.009038124 0.166282876 1.43637566 0.59504841 cgl3433272 CDK8 1024 2.63027 0.009040482 0.166282876 1.43318682 0.58657725 cg01684579 HSPC111 51491 -2.62995 0.009048932 0.166282876 0.69782843 0.58786305 cgl3006591 TLR6 10333 -2.62987 0.009051026 0.166282876 0.68639171 0.57296289 cgl6581199 TSSK1 83942 -2.62974 0.009054427 0.166282876 0.69015504 0.59217426 cg06502510 ITS 1 6453 2.6295 0.009060681 0.166282876 1.44912709 0.59005647 cg27132814 C20orf79 140856 -2.62879 0.009079025 0.166413589 0.69066656 0.57039129 cg05626013 LRRTM3 347731 2.62855 0.009085208 0.166413589 1.43292444 0.58577047 cg21903324 CABYR 26256 2.6282 0.009094452 0.166423501 1.43024019 0.58254336 cg23660082 CST1 1469 -2.62718 0.00912087 0.166747374 0.69832813 0.59328358 cg26516764 APRIN 23047 2.6266 0.009136103 0.166866329 1.42851838 0.59726704
cg06392589 FNDC6 152028 -2.62581 0.009156745 0.166932256 0.69876831 0.59898144 cgl ll52574 ACSL5 51703 -2.62561 0.009161913 0.166932256 0.69000395 0.57245865 cg02311163 SEMG2 6407 -2.62517 0.009173647 0.166932256 0.69694155 0.58972872 cgl4813406 CDC14A 8556 2.625 0.009178108 0.166932256 1.43847862 0.58763614 eg 14490250 FAM96A 84191 2.6248 0.00918336 0.166932256 1.42997086 0.5665591 cg01889448 HLA-DQB1 3119 -2.62354 0.009216434 0.167274902 0.70264993 0.59701493 cgl9275050 HAS2 3037 2.62341 0.009219704 0.167274902 1.45272335 0.58693021 cg09748960 BTNL2 56244 -2.6228 0.009235929 0.167410435 0.69261528 0.57845906 cgl6625125 NUDT8 254552 2.62219 0.00925209 0.167544552 1.42004835 0.59570391 cgl9548738 KIAA0738 9747 2.62052 0.009296271 0.167760539 1.44783905 0.60790641 cg08258650 SLC1A2 6506 2.62052 0.009296355 0.167760539 1.43259455 0.60825938 cg27351998 IFNA5 3442 -2.6204 0.009299463 0.167760539 0.70208825 0.57709762 cgl6543027 PLCB2 5330 2.61988 0.009313212 0.167760539 1.41908197 0.58622428 cg27079104 HEXA 3073 2.61887 0.009340211 0.167760539 1.42198934 0.57371924 cg24777454 LRRC34 151827 2.61885 0.009340748 0.167760539 1.42618852 0.57649254 cgl6731016 LGALS4 3960 -2.61845 0.009351317 0.167760539 0.69719295 0.57866075 cg21787280 FU25976 283579 -2.6182 0.009358135 0.167760539 0.69261759 0.58824123 cgl6495265 HOXB5 3215 2.61783 0.009367871 0.167760539 1.45088958 0.58400565 cgl0303842 CDH12 1010 2.61764 0.009372968 0.167760539 1.43698903 0.57977007 cg22334000 MGC35043 255119 2.61743 0.009378692 0.167760539 1.43225432 0.60074627 cg08496998 TRIAD3 54476 -2.61735 0.009380756 0.167760539 0.68634068 0.57987092 eg 19447966 TEAD1 7003 -2.61679 0.009395748 0.167760539 0.6985668 0.59146833 cg20938689 COX7C 1350 2.6163 0.009408942 0.167760539 1.44690036 0.5742739 cg20576510 PROM1 8842 -2.61589 0.009419823 0.167760539 0.69858016 0.57608915 cg09911342 ASZ1 136991 -2.61572 0.009424475 0.167760539 0.69314205 0.58178701 cgl5972294 GNAI2 2771 2.61566 0.009425965 0.167760539 1.43801244 0.56202098 cg03608974 ZAK 51776 2.61532 0.00943509 0.167760539 1.42675912 0.58682937 eg 11434468 XKR6 286046 2.61525 0.009437142 0.167760539 1.42087668 0.58254336 cgl l267879 CYP2F1 1572 -2.61454 0.009456328 0.167760539 0.69296843 0.57543364 cgl7897236 NIPA2 81614 2.61406 0.009469236 0.167760539 1.42145634 0.56605486 cg01092036 MMP8 4317 -2.61396 0.009471943 0.167760539 0.6941989 0.57977007 cgl3384498 CRYGB 1419 -2.61325 0.009491011 0.167760539 0.68522983 0.59530052 cgl8665384 FU43505 400823 -2.61275 0.009504614 0.167760539 0.69375116 0.58970351 cg23737055 ANKRD46 157567 2.61246 0.009512398 0.167760539 1.45081905 0.57825736 cg00415993 F2RL2 2151 2.61233 0.009515833 0.167760539 1.44559189 0.59167003 cgl0218646 ZBTB11 27107 2.61218 0.009520109 0.167760539 1.42262672 0.59535095 cg25756129 SFRS10 6434 2.61187 0.009528569 0.167760539 1.42779792 0.59812424 cg21615127 TMC04 255104 2.61164 0.009534682 0.167760539 1.43431537 0.58329972 cg26728886 Clorfll8 374987 2.61162 0.009535116 0.167760539 1.42322595 0.57886245 cg00256166 KLHL25 64410 2.61159 0.009535972 0.167760539 1.42487441 0.57472771 cg27250462 OTEX 158800 -2.61072 0.00955976 0.168024454 0.6956577 0.58516539 cg05389183 PPIC 5480 2.60988 0.009582474 0.168269024 1.42731714 0.60009076
cg09212058 PRKD3 23683 -2.60805 0.00963262 0.168908394 0.68982297 0.57903893 cgl l330108 BCL2 596 2.60791 0.00963655 0.168908394 1.43487601 0.58811517 eg 18994063 TIMD4 91937 -2.60729 0.009653611 0.169052476 0.69572975 0.5864764 cg06433658 FAM63A 55793 2.60641 0.009677742 0.169190735 1.41713678 0.58718233 cg20770175 COL3A1 1281 -2.60574 0.009696117 0.169190735 0.69453146 0.56492033 cg06117855 CLEC3B 7123 2.6053 0.009708232 0.169190735 1.41317393 0.56953409 cgl8668753 PEG3 5178 -2.60505 0.009715165 0.169190735 0.7058707 0.58113151 cg20731798 LOC119710 119710 2.60486 0.009720511 0.169190735 1.42595239 0.58511497 cg21557231 MCF2 4168 -2.60461 0.009727418 0.169190735 0.69331662 0.58713191 cg23580945 FU43826 342666 -2.60411 0.009741144 0.169190735 0.70029724 0.59832594 cg04737405 OR12D2 26529 -2.60403 0.009743299 0.169190735 0.70553441 0.59083804 cg24324379 IDH1 3417 2.60403 0.0097435 0.169190735 1.4362523 0.58889673 cg00577464 SHH 6469 2.60336 0.009761903 0.169190735 1.4162828 0.59293062 cgl l930592 MSX1 4487 2.6033 0.009763658 0.169190735 1.44479816 0.58551835 cgl7671157 KCNK10 54207 2.60315 0.009767676 0.169190735 1.42601061 0.59000605 cg03077492 CCL28 56477 -2.60136 0.009817522 0.169900241 0.69655971 0.5873336 cg22805632 KRT10 3858 -2.59826 0.009904472 0.170422933 0.69451451 0.55783582 cg04529955 C4otfl3 84068 2.59813 0.00990793 0.170422933 1.4148597 0.596309 cgl3669465 EX0SC1 51013 2.59794 0.009913456 0.170422933 1.44112912 0.59383824 cgl3752005 CCDC64 92558 2.59776 0.009918339 0.170422933 1.41910888 0.568929 cg00573606 COL6A3 1293 -2.59742 0.009927952 0.170422933 0.70336317 0.59736789 cgl2491659 FU33641 202309 2.5971 0.009937046 0.170422933 1.42770565 0.58329972 cgl4923435 EPB41L5 57669 2.59706 0.009938064 0.170422933 1.41670945 0.59731747 cgl7522249 ARTS-1 51752 2.59699 0.009940075 0.170422933 1.41129517 0.59061113 cg07009002 MB 4151 2.59678 0.009945948 0.170422933 1.42638079 0.59005647 cg24433189 SSTR5 6755 -2.59667 0.009949078 0.170422933 0.71049135 0.56202098 cg07674153 TSHR 7253 2.5966 0.009951083 0.170422933 1.42318667 0.58617386 cg03332113 RAI14 26064 2.59626 0.009960713 0.170422933 1.44252154 0.59056071 cg21087137 MGC26856 256710 2.59616 0.009963581 0.170422933 1.42476111 0.59600645 cgl4512008 PPP2R5C 5527 2.59579 0.009974081 0.170444396 1.4522462 0.59600645 cg03900542 DEDD2 162989 2.59548 0.009982662 0.170444396 1.41981027 0.5873336 eg 18940763 XBP1 7494 2.59447 0.010011303 0.170689212 1.42944731 0.57538322 cg01139966 G0LPH3L 55204 2.59409 0.010022205 0.170689212 1.44095898 0.58854377 cg06714705 0LFML1 283298 -2.59386 0.010028698 0.170689212 0.69230661 0.58859419 cg08861115 IL1F9 56300 -2.59345 0.01004023 0.170689212 0.69396551 0.57482856 cg03802231 FNTA 2339 -2.59324 0.010046275 0.170689212 0.70203113 0.57992134 cgl5062535 ZNF610 162963 -2.59261 0.010064285 0.170689212 0.68602145 0.58395522 cgl8312807 RAB3GAP1 22930 2.59165 0.010091568 0.170689212 1.43831202 0.58708148 eg 19343464 GRIA4 2893 2.59118 0.01010511 0.170689212 1.42175112 0.60205728 cg05045383 RAE1 8480 2.5911 0.010107339 0.170689212 1.42643499 0.58672852 cgl6222762 SYT4 6860 2.59013 0.010135038 0.170689212 1.43961662 0.59388867 eg 16794882 PMCHL2 5370 -2.59007 0.010136959 0.170689212 0.70843507 0.60029246
eg 19478478 TRDN 10345 -2.58978 0.010145155 0.170689212 0.69598227 0.58203913 cg09305478 MGC15416 84331 -2.58972 0.010146949 0.170689212 0.70200648 0.58168616 cgl5869642 CBLN1 869 -2.58952 0.010152559 0.170689212 0.70229027 0.580476 cg26560960 CBWD2 150472 2.58936 0.010157202 0.170689212 1.42406833 0.56348326 eg 12561748 ZNF307 387032 2.58871 0.010175983 0.170689212 1.44147708 0.57059298 cg27185377 PTTG1 9232 2.5885 0.010182026 0.170689212 1.43750209 0.58930012 cg23850272 ZNF228 7771 2.58848 0.010182594 0.170689212 1.41499363 0.57845906 eg 14659547 RET LB 84666 -2.58831 0.010187459 0.170689212 0.69820647 0.58854377 cg06378617 KRT23 25984 -2.58774 0.010204081 0.170689212 0.699811 0.5751311 cg24731756 ILK 3611 2.58763 0.010207128 0.170689212 1.42645826 0.58450988 cg26555310 RPE65 6121 -2.58723 0.010218781 0.170689212 0.69386388 0.58466115 cg09142399 CRYZ 1429 -2.58669 0.010234295 0.170689212 0.69059426 0.5866781 cg26235710 FU38984 127703 2.58646 0.010241068 0.170689212 1.4404347 0.57795482 eg 16863447 TMEM117 84216 -2.58605 0.010252683 0.170689212 0.70446102 0.58224082 cgl2757684 PLAGL1 5325 2.58585 0.010258585 0.170689212 1.44049297 0.58481242 cgl9358493 EMX2 2018 2.58573 0.010262045 0.170689212 1.42069537 0.5866781 cg21727574 ZNF137 7696 -2.58552 0.010268313 0.170689212 0.70201286 0.58521581 cgl l701148 MYOM2 9172 2.58545 0.010270317 0.170689212 1.42041043 0.58198871 cg24801210 PCNP 57092 2.58523 0.010276579 0.170689212 1.43245339 0.58087939 cgl9718882 WIT-1 51352 2.58519 0.010277857 0.170689212 1.42227961 0.60084712 cg24628744 H2AFY 9555 2.58473 0.010291242 0.170689212 1.43473712 0.57548407 cgl0339201 F9 2158 -2.58439 0.010301119 0.170689212 0.70051226 0.59590561 cg06225581 ZMAT2 153527 2.58418 0.010307155 0.170689212 1.40876643 0.61541952 cg09412782 C15orf48 84419 -2.5841 0.010309406 0.170689212 0.68654719 0.57134933 cg27164762 HIGD2A 192286 2.58299 0.01034197 0.171080237 1.42254699 0.57916499 cg04658354 BRCA1 672 2.58204 0.010369676 0.171210043 1.4261389 0.58687979 cg21935083 RAD50 10111 2.58185 0.010375301 0.171210043 1.43995533 0.58002219 cg06122080 OXSM 54995 2.5818 0.010376676 0.171210043 1.42955326 0.57422348 cg23214764 PRSS23 11098 2.58115 0.010395821 0.171257263 1.43153932 0.57971965 cg24453353 HIST1H4C 8364 2.58109 0.010397449 0.171257263 1.42339419 0.58244252 cg21649520 PMP2 5375 -2.58068 0.010409582 0.171309553 0.6938363 0.58708148 cg22609784 MSX1 4487 2.57961 0.010440966 0.17167828 1.41878054 0.58173659 cg07356189 CXorf2 1527 -2.57904 0.010457876 0.171734933 0.69760012 0.58037515 cgl9692710 DNAJB13 374407 -2.57839 0.010477119 0.171734933 0.70056613 0.56882816 cg27622610 OR1G1 8390 -2.57826 0.010480928 0.171734933 0.69327108 0.6012505 cg25203856 NALP14 338323 -2.57821 0.010482415 0.171734933 0.70467276 0.57709762 eg 16434546 SDCCAGIO 10283 2.57797 0.010489314 0.171734933 1.42443306 0.58042558 eg 11808544 FKBP9L 360132 -2.57761 0.010499953 0.171762059 0.70147043 0.57780355 eg 11390468 IFT57 55081 2.57717 0.010513022 0.171828858 1.43390585 0.5901069 cgl4550518 ZNF659 79750 2.57645 0.010534525 0.171963257 1.42587234 0.58970351 cg06394897 AK2 204 2.57629 0.01053923 0.171963257 1.42915786 0.58491327 cg07211259 PDCD1LG2 80380 2.57525 0.010570271 0.172322703 1.43262579 0.59842679
cgl4532519 TCF20 6942 -2.57303 0.010636513 0.172934782 0.69226299 0.59918314 cg02523400 SERPINDl 3053 -2.57271 0.010646184 0.172934782 0.70244384 0.57180315 cg06583518 ZNF571 51276 2.572 0.010667394 0.172934782 1.43416169 0.59373739 cg25355065 SFXN2 118980 2.57191 0.010669989 0.172934782 1.42102318 0.58052642 cg09794131 HYDIN 54768 2.57104 0.010696211 0.172934782 1.41297471 0.58314845 cg07236769 IFNW1 3467 -2.57063 0.010708433 0.172934782 0.70111328 0.58355184 cg05467167 G0SR2 9570 2.57015 0.010723199 0.172934782 1.4185169 0.59025817 cg03808835 PCDH15 65217 2.57007 0.010725331 0.172934782 1.41808469 0.59298104 cgl7703324 OPTC 26254 -2.56991 0.010730333 0.172934782 0.70437064 0.58375353 cgl8676679 BA P 54971 2.56989 0.010730883 0.172934782 1.42802092 0.58274506 cg20811607 SMPD2 6610 -2.5698 0.010733663 0.172934782 0.7072372 0.58123235 cg05661838 MOS 4342 2.56974 0.010735299 0.172934782 1.41268389 0.57780355 cg23822915 CYB5R4 51167 2.56944 0.010744353 0.172934782 1.41225281 0.57760186 cgl6525692 CHD1L 9557 2.56854 0.010771742 0.172934782 1.42529963 0.58087939 cg23612220 TNFAIP8L2 79626 2.56782 0.010793585 0.172934782 1.43498693 0.58269464 cg05921581 KRT1B 374454 -2.56777 0.010795119 0.172934782 0.69226697 0.59343485 cg02686662 PPAP2C 8612 2.56754 0.010801958 0.172934782 1.43902212 0.57911456 cg02205739 PRRX2 51450 2.56711 0.010815159 0.172934782 1.43409802 0.60437677 cg24387380 GABRA5 2558 -2.56681 0.010824145 0.172934782 0.70068377 0.58450988 cg20647137 AKR1D1 6718 -2.56625 0.010841172 0.172934782 0.68614792 0.5873336 eg 14863484 GOT2 2806 2.56625 0.010841444 0.172934782 1.40444422 0.58783784 cg09845785 PDE1A 5136 2.56559 0.010861371 0.172934782 1.42622329 0.60094796 cgl4654385 URP2 83706 2.56556 0.010862423 0.172934782 1.420115 0.60967124 cgl2706983 ZNF435 80345 2.56536 0.010868438 0.172934782 1.43892495 0.57578661 cgl0035303 TRPC4AP 26133 2.56533 0.010869392 0.172934782 1.42350899 0.58208955 cgl4275779 PLEKHH3 79990 2.56529 0.010870533 0.172934782 1.40134336 0.60604074 cgl l933375 FU10815 55238 2.56524 0.010872124 0.172934782 1.42516976 0.59252723 cgl9033555 DEFB1 1672 -2.56513 0.010875595 0.172934782 0.70418363 0.57694635 cg01941619 MEP1B 4225 -2.56502 0.010878869 0.172934782 0.69699351 0.5969645 cgl2965512 TSPAN8 7103 -2.56483 0.010884651 0.172934782 0.70248672 0.5943929 cg22244122 SURF4 6836 2.56471 0.010888159 0.172934782 1.40717398 0.57664381 cg21497439 HAPLN4 404037 -2.56434 0.010899758 0.172975352 0.70461102 0.58208955 cg06545504 HTN1 3346 -2.5638 0.010916143 0.173006385 0.6990323 0.57694635 cgl l871280 SLC16A7 9194 -2.56327 0.010932526 0.173006385 0.69780354 0.58123235 cg20551517 GIP 2695 -2.56293 0.01094286 0.173006385 0.70060659 0.57503025 cgl4281165 PIGO 84720 -2.56292 0.010943125 0.173006385 0.71297967 0.58007261 cg09244244 KIAA0372 9652 2.56256 0.010954377 0.173006385 1.42982037 0.59736789 cg05194726 NRIP2 83714 2.56247 0.010956875 0.173006385 1.41676476 0.58012303 cgl3794642 ZNF157 7712 -2.56162 0.010983265 0.173006385 0.70526762 0.57573618 cg09212468 C16orf50 84229 2.56122 0.01099557 0.173006385 1.43783299 0.60281364 cg09906309 Cllorf46 120534 2.56073 0.011010583 0.173006385 1.40842768 0.59288019 cgl8986713 LEPROTLl 23484 -2.56068 0.011012346 0.173006385 0.70602021 0.60135135
cg25918245 GIMAP2 26157 2.55941 0.011051482 0.173006385 1.44646199 0.58284591 cg20678353 FU35695 400359 2.55937 0.011052853 0.173006385 1.43417762 0.58834207 cg02765820 C3orf22 152065 -2.55931 0.011054527 0.173006385 0.69708312 0.57271077 cg02312170 BRWD2 55717 2.55862 0.011075888 0.173006385 1.417208 0.59499798 cg26745540 NPY1R 4886 2.55858 0.011077203 0.173006385 1.43405717 0.58274506 cgl l698653 ASB5 140458 -2.55852 0.011079219 0.173006385 0.70563141 0.58577047 cg24430616 ENTPD4 9583 -2.55819 0.011089294 0.173006385 0.70443502 0.58703106 cgl8881723 SLAMF1 6504 2.55807 0.011093107 0.173006385 1.42239837 0.59403994 cg26960719 KCNJ16 3773 -2.55789 0.011098617 0.173006385 0.70747952 0.58642598 cgl3477510 Sep-05 5413 -2.557 0.011126305 0.173006385 0.69973277 0.57049213 cgl6698623 MGMT 4255 -2.55697 0.01112731 0.173006385 0.70164435 0.58360226 cg00838150 MITF 4286 2.55684 0.011131296 0.173006385 1.41341151 0.58788826 cg06491924 ZNF613 79898 2.55679 0.011132823 0.173006385 1.42968731 0.58299718 cgl ll47193 HPCAL1 3241 2.55652 0.011141488 0.173006385 1.4006491 0.59333401 cg20203395 MGC33648 133383 2.5565 0.011141902 0.173006385 1.40813281 0.59298104 cgl l511443 LM03 55885 2.55634 0.011146906 0.173006385 1.41000327 0.59177088 cg08687958 PDZD8 118987 2.55633 0.011147457 0.173006385 1.41015633 0.60296491 cg06504820 DLK1 8788 -2.55591 0.011160432 0.173006385 0.70553697 0.59893102 cg24987706 GPA33 10223 -2.55553 0.011172318 0.173006385 0.69714812 0.59852763 eg 10866709 GATA4 2626 2.55519 0.011183134 0.173006385 1.40599072 0.59600645 cg02612026 CASP9 842 2.55512 0.011185286 0.173006385 1.42319725 0.58148447 cgl3577076 PRKAR1B 5575 2.55493 0.01119122 0.173006385 1.41185923 0.58148447 cgl0234985 IZUMOl 284359 2.55406 0.011218485 0.173287786 1.40705975 0.5883925 eg 24841244 CD3D 915 -2.55337 0.011240202 0.173316958 0.71157938 0.57921541 cg09195271 RNF186 54546 -2.55296 0.011252943 0.173316958 0.70198208 0.58377874 cg21578906 SLC5A4 6527 -2.55226 0.011275085 0.173316958 0.70557504 0.57830779 eg 16449972 ZNF423 23090 -2.55201 0.011283157 0.173316958 0.69692668 0.57508068 eg 11997899 DLX5 1749 2.55176 0.011291011 0.173316958 1.42435889 0.56877773 cg20849987 LUZP4 51213 -2.55175 0.011291124 0.173316958 0.70203675 0.57099637 cg02630207 FU10379 55133 -2.55172 0.011292244 0.173316958 0.70223508 0.57840863 cg06793062 CNTNAP4 85445 -2.5517 0.01129288 0.173316958 0.70605573 0.57840863 cg04796162 IGFBP3 3486 2.55112 0.011311205 0.173394277 1.4268252 0.58022388 cg01429996 NANS 54187 2.55096 0.011316052 0.173394277 1.43695804 0.58945139 cgl2880658 CDOl 1036 2.55024 0.011339136 0.173562359 1.4142261 0.59998992 cg23588893 FUT11 170384 2.55005 0.011345174 0.173562359 1.41256514 0.58728318 cgl9256236 KCNH3 23416 2.54962 0.011358789 0.173631738 1.39404536 0.57195442 cg26454191 PMS1 5378 2.54856 0.011392529 0.173856824 1.41307152 0.58506454 cg26135716 GLUL 2752 -2.54807 0.011408048 0.173856824 0.70473011 0.56968536 cg21431091 TMEM9 252839 2.5477 0.011419908 0.173856824 1.4052253 0.56630698 cg05773628 NCKAP1 10787 2.54765 0.011421451 0.173856824 1.43952639 0.58955224 eg 14800883 ARPC4 10093 2.54729 0.011432774 0.173856824 1.42062363 0.56902985 cg09604428 PB1 55193 -2.54691 0.011444986 0.173856824 0.69786233 0.58768657
cg00935388 RNASE8 122665 -2.54689 0.011445841 0.173856824 0.7017762 0.59998992 eg 10704545 GLRX2 51022 -2.54682 0.011448081 0.173856824 0.70186614 0.5785599 cg00402366 LRRC44 127255 2.54659 0.011455337 0.173856824 1.42056515 0.59474587 cg00828602 WNT5A 7474 2.54601 0.01147389 0.173874711 1.42541963 0.5708451 cgl4808739 SREBF1 6720 -2.54598 0.011474701 0.173874711 0.70129705 0.59227511 cg27530424 YBX1 4904 -2.54511 0.011502839 0.17401747 0.71023298 0.58803953 cgl4153740 TRY1 136541 -2.54489 0.011509866 0.17401747 0.7019292 0.56897943 cgl8503260 CA13 377677 2.54484 0.011511422 0.17401747 1.42194717 0.59172045 cg23047271 PRICKLE2 166336 2.54442 0.011524854 0.174081842 1.42612982 0.57724889 eg 17449882 C8orf46 254778 -2.54414 0.011533887 0.174081842 0.69867724 0.57039129 cg24167928 UTP14C 9724 -2.54344 0.01155645 0.174284832 0.70216928 0.57734974 cg20518716 EEF1G 1937 2.54258 0.011584356 0.17443899 1.40810718 0.58138362 cgl8672421 TMED10 10972 2.54256 0.011584916 0.17443899 1.41135673 0.56988705 eg 14776962 HIST1H2BH 8345 2.54093 0.011637756 0.175096748 1.42368652 0.58314845 cg27217148 PCGF6 84108 2.53995 0.011669484 0.17540323 1.41255454 0.59429205 cgl3975625 NPY5R 4889 2.53974 0.011676471 0.17540323 1.40425781 0.57634127 cg08120190 C7orf36 57002 2.53889 0.011704195 0.175622073 1.41280276 0.58698064 cg05440289 IVL 3713 -2.53866 0.011711543 0.175622073 0.70130033 0.58501412 eg 18694780 CMK0R1 57007 2.53775 0.011741405 0.175622073 1.42009146 0.5935357 cg09260441 D0K5 55816 2.5376 0.011746445 0.175622073 1.41848298 0.60014119 cg26174387 TMEM30A 55754 2.53754 0.011748294 0.175622073 1.41323201 0.57175272 cg08214029 CCL18 6362 -2.53747 0.011750677 0.175622073 0.69739498 0.59363655 cgl7864730 ITGB8 3696 2.5368 0.011772404 0.175622073 1.41354332 0.58042558 cgl0882227 APLP2 334 2.53642 0.011785014 0.175622073 1.42606507 0.57366882 eg 14603406 TRIM 8 81603 -2.5364 0.011785585 0.175622073 0.71272663 0.58259379 cg03490115 ZNHIT4 83444 2.53626 0.01179011 0.175622073 1.43694562 0.58319887 cg03663715 F0XD1 2297 2.53606 0.011796804 0.175622073 1.42010053 0.58062727 cg01808130 SLC35B3 51000 2.53592 0.011801245 0.175622073 1.41879834 0.58987999 cg25685640 E2F8 79733 2.53558 0.011812553 0.175651301 1.42948863 0.56842477 cgl9353006 TUSC3 7991 -2.53531 0.01182158 0.175651301 0.70327676 0.5892497 eg 16907488 CCDC17 149483 -2.5347 0.011841579 0.175720802 0.70091822 0.57119806 cg27542948 ERV3 2086 -2.53458 0.011845625 0.175720802 0.70512576 0.58098023 cgl ll02794 LM01 4004 2.53382 0.011870429 0.175720802 1.41528172 0.59691408 cg05040429 SAMD12 401474 2.53326 0.011889144 0.175720802 1.41640993 0.58940097 cgl9734148 RAE1 8480 2.53314 0.011893089 0.175720802 1.40901797 0.58113151 cgl3741326 TP53AP1 11257 2.5331 0.011894422 0.175720802 1.41991407 0.57810609 cgl5973234 KIAA1199 57214 -2.53294 0.011899531 0.175720802 0.71039095 0.57074425 cg07589355 RBMS2 5939 2.53215 0.011925736 0.175720802 1.42904291 0.58395522 cg04377282 NODAL 4838 2.53201 0.011930382 0.175720802 1.40592688 0.5594998 cg00986320 CYFIP2 26999 -2.53195 0.01193238 0.175720802 0.69957498 0.5883925 cg08132767 ARL1 400 2.5319 0.011934061 0.175720802 1.41311578 0.6057382 cgl4070162 PTRF 284119 2.53183 0.011936525 0.175720802 1.41745262 0.58486285
cg06993413 DPP8 54878 2.53127 0.011955051 0.175858143 1.42922358 0.59328358 cg24650394 PLEKHH2 130271 -2.53035 0.011985703 0.176173514 0.70081337 0.58521581 cg05130485 CASP8 841 2.52965 0.012008922 0.176379228 1.42268738 0.5881908 cg25156443 SFRP5 6425 2.52926 0.012022143 0.176437903 1.41609908 0.58355184 cgl5894661 PHACS 84680 2.52795 0.012066031 0.176898263 1.40510444 0.57029044 cg04806409 TFF3 7033 -2.52733 0.012086604 0.176898263 0.70984197 0.58249294 cg04060163 SEC14L1 6397 2.52726 0.012089249 0.176898263 1.39517763 0.59282977 cg04137128 SIN3A 25942 2.5269 0.012101267 0.176898263 1.4149413 0.57714804 cg20559736 CEACAM 19 56971 -2.52667 0.012108999 0.176898263 0.7157858 0.59797297 cgl5384392 ARHGAP1 392 2.52658 0.012111826 0.176898263 1.41582063 0.58566963 cg08141463 PLA1A 51365 -2.52629 0.012121555 0.176898263 0.70485373 0.59242638 cg27464755 HMGN4 10473 2.52612 0.012127516 0.176898263 1.41826188 0.59842679 cg20063650 ZNF645 158506 -2.52572 0.012141042 0.176960577 0.70657423 0.58319887 cg07405796 TRIM40 135644 2.52416 0.012193622 0.177544357 1.41371417 0.5978217 cg22830895 CRYGN 155051 2.52398 0.012199663 0.177544357 1.38872467 0.58024909 cg03383661 TBCC 6903 -2.52364 0.012211281 0.177578289 0.64953487 0.5455829 cg27214365 GYPB 2994 -2.5231 0.012229673 0.177710609 0.69971322 0.57437475 cgl8084791 SLAMF8 56833 -2.52256 0.01224794 0.17784091 0.70756204 0.57069383 cgl0189763 MUC7 4589 2.52224 0.012258823 0.177863889 1.40031778 0.59895623 cg22184145 P0LR2B 5431 2.52131 0.012290455 0.178067825 1.41658982 0.57971965 cg27140880 RPL37A 6168 2.52097 0.012302085 0.178067825 1.42182283 0.58420734 cgl9630689 SERPINA12 145264 2.5207 0.012311327 0.178067825 1.43406891 0.584762 eg 11649825 C20orf4 25980 2.52063 0.012313418 0.178067825 1.42044033 0.58269464 cg03547797 GAS 2 2620 2.52046 0.012319438 0.178067825 1.41043141 0.59333401 cgl4963897 NFS1 9054 -2.51887 0.012373697 0.17843939 0.70809334 0.59101452 cg09839960 HBII-438B 338429 -2.51879 0.012376658 0.17843939 0.70727209 0.58602259 cg23998987 TBL3 10607 2.51839 0.012390168 0.17843939 1.405809 0.59121622 cg09408780 SFTPG 389376 -2.51815 0.012398383 0.17843939 0.70626584 0.58229125 cgl4106308 VEPH1 79674 2.51808 0.012400816 0.17843939 1.41655599 0.58829165 cg25300386 C0L1A2 1278 2.51765 0.012415687 0.17843939 1.39971818 0.58955224 cg05670348 LARGE 9215 2.51724 0.012429643 0.17843939 1.40037497 0.56933239 cg06384463 BARHL2 343472 2.51709 0.012434906 0.17843939 1.40755935 0.57205526 cgl6517394 TNFSF4 7292 2.51659 0.012452328 0.17843939 1.43376144 0.57611436 cg24887211 C14orfl66B 145497 -2.51633 0.012461165 0.17843939 0.70828658 0.57734974 cg25021182 ELA2B 51032 -2.51631 0.012461861 0.17843939 0.70464992 0.57835821 cg07908874 TUBGCP2 10844 2.51602 0.012471959 0.17843939 1.39764705 0.6031666 cg04176254 AGRP 181 -2.51582 0.012478775 0.17843939 0.71389176 0.56514724 cg02022375 KRTAPl-1 81851 -2.51556 0.012487847 0.17843939 0.70959933 0.58980436 cg24266238 PFN2 5217 2.51502 0.012506486 0.17843939 1.40640073 0.5892497 cgl9629292 ZNF312 55079 2.515 0.012507224 0.17843939 1.40785746 0.56615571 cg27351358 BDNF 627 2.51474 0.01251617 0.17843939 1.42654824 0.57964401 cg02397720 RAB17 64284 2.51452 0.012523583 0.17843939 1.4206181 0.57008875
cg24693909 RG9MTD2 93587 2.51447 0.012525422 0.17843939 1.43217221 0.59030859 cg07380959 TFPI2 7980 2.51328 0.012566612 0.17843939 1.4145884 0.59519968 eg 13463367 PSMC2 5701 2.51321 0.012569147 0.17843939 1.40653399 0.57306374 cg00893987 RPL7L1 285855 2.51317 0.012570658 0.17843939 1.40925656 0.58289633 cg01803059 SMAD1 4086 2.51312 0.012572254 0.17843939 1.40621493 0.58652683 cgl5928132 CCKAR 886 -2.51266 0.012588183 0.17843939 0.70142982 0.57366882 cgl5166050 LCTL 197021 -2.51262 0.01258985 0.17843939 0.71052399 0.57835821 cg06490951 CETN1 1068 2.51225 0.012602656 0.17843939 1.43620119 0.58012303 cgl7778120 RBP2 5948 -2.51218 0.012605113 0.17843939 0.70867966 0.59898144 cgl2781395 SNW1 22938 2.51184 0.012617053 0.17843939 1.41700088 0.57301331 cgl3471990 ENTPD1 953 2.51104 0.012644763 0.17843939 1.40727675 0.56368495 cg06325687 0PN1MW 2652 -2.51068 0.012657466 0.17843939 0.70591179 0.55884429 cg23731764 EXOSC10 5394 2.51065 0.012658627 0.17843939 1.4170285 0.57336628 cgl5694180 ADAM15 8751 -2.51047 0.012664836 0.17843939 0.69834175 0.57069383 cg20769102 POLR2K 5440 2.51017 0.012675167 0.17843939 1.41094864 0.5841065 cg03218374 ANGPT4 51378 2.51014 0.012676182 0.17843939 1.39532401 0.57951795 cg00766729 LOC147808 147808 2.50995 0.012682996 0.17843939 1.40068463 0.56544978 cg27379417 PGBD4 161779 2.50988 0.012685263 0.17843939 1.40011467 0.59777128 cg04098585 CD28 940 2.5095 0.012698705 0.17843939 1.4149991 0.58092981 cg25421694 RAB5A 5868 2.50929 0.01270605 0.17843939 1.42444788 0.59277935 cg22478328 YWHAH 7533 -2.50921 0.01270906 0.17843939 0.70576294 0.58748487 cg22298208 C7orf34 135927 -2.50873 0.01272594 0.178519198 0.69217805 0.58556878 cg06641366 LRRC8C 84230 -2.50851 0.012733415 0.178519198 0.71372238 0.59035902 cgl0091705 PPP1R12B 4660 2.5072 0.012779675 0.178644922 1.40038713 0.58793869 cgl8063149 FM03 2328 -2.50717 0.012780818 0.178644922 0.70594632 0.57888766 cg25631352 ADD2 119 2.50683 0.012792757 0.178644922 1.40687186 0.58466115 cgl6381752 TOR1AIP2 163590 2.50617 0.012815988 0.178644922 1.4506042 0.58178701 cgl3870494 MAMDC2 256691 -2.50595 0.012824013 0.178644922 0.71533229 0.59136749 cgl9873701 PSG9 5678 -2.5059 0.012825652 0.178644922 0.7094247 0.57109722 cg03872376 ZP4 57829 -2.50541 0.012842839 0.178644922 0.70946239 0.58708148 cgl7895149 PLAGL1 5325 2.50524 0.012848994 0.178644922 1.43678041 0.58597217 cg03127543 NXF5 55998 -2.50497 0.012858416 0.178644922 0.71295629 0.58899758 cg09429153 PBX3 5090 2.50493 0.012859922 0.178644922 1.42625013 0.59252723 cgl0429262 GPR157 80045 2.5048 0.012864473 0.178644922 1.42743571 0.59479629 cg24290574 CPA3 1359 2.50474 0.012866796 0.178644922 1.42096272 0.57810609 cgl4633704 HSD17B3 3293 -2.50454 0.012873998 0.178644922 0.71093236 0.56665994 cg09196942 PRAMEF1 65121 -2.504 0.012892875 0.178644922 0.71823562 0.61078056 cg21101222 ATOX1 475 2.50373 0.012902685 0.178644922 1.40037809 0.5612142 cgl2576145 AMMECR1 9949 2.50348 0.012911476 0.178644922 1.42108952 0.59252723 cg27285599 FU13841 79755 -2.50302 0.012928046 0.178644922 0.70543457 0.55526422 cg03561565 KCNS2 3788 2.503 0.012928561 0.178644922 1.39950479 0.58491327 cgl9832721 KIAA1267 284058 2.50269 0.012939856 0.178644922 1.41552816 0.60528439
cg03746685 TMEM126B 55863 2.50254 0.012945118 0.178644922 1.41182713 0.58814038 cgl8787783 MMP19 4327 -2 .50192 0.012967225 0.178644922 0.70898714 0.57745059 cgl4378057 KIAA0240 23506 -2 .50189 0.012968224 0.178644922 0.7189816 0.58229125 cg22211866 HMG20A 10363 2 .50158 0.01297947 0.178644922 1.40477001 0.57694635 cgl l015241 ATP 1 OA 57194 -2 .50152 0.012981329 0.178644922 0.70446715 0.57815652 cg05964373 TEX9 374618 2 .50128 0.012990031 0.178644922 1.39459085 0.5945946 cgl6998207 FCMD 2218 2 .50123 0.012991882 0.178644922 1.40753986 0.57608915 cg01568335 C0X5B 1329 2 .50115 0.012994615 0.178644922 1.38957321 0.59822509 cg06222800 KRTAP21-1 337977 -2 .50021 0.013028362 0.178980199 0.69877372 0.58375353 eg 14376424 FAM71B 153745 -2 .49911 0.01306804 0.179396401 0.70844538 0.56615571 cgl7017278 TRUB1 142940 2 .49796 0.013109286 0.179702275 1.42310583 0.5881908 cgl7918700 KC K7 10089 -2 .49795 0.013109742 0.179702275 0.71216681 0.58244252 cg02241259 IL23R 149233 -2 .49771 0.013118512 0.179702275 0.70569416 0.56499597 cgl9486271 DDB2 1643 2 .49736 0.013131266 0.179748215 1.39489686 0.56418919 cgl ll89837 ADAMTS1 9510 2 .49698 0.013144789 0.179804628 1.39075299 0.57719847 cg08001895 EPHA7 2045 2 .49664 0.013157107 0.179844468 1.40803458 0.57250908 cg05181279 RIG 10530 -2 .49632 0.013168895 0.179862907 0.7093879 0.59751916 cgl2960248 MGC11335 81577 2 .49585 0.013185769 0.179862907 1.40477443 0.59136749 cgl7356112 PLXNA4B 91584 -2 .49583 0.013186673 0.179862907 0.70925054 0.59045986 cgl2846567 ZNF556 80032 -2 .49534 0.013204138 0.179972768 0.7066548 0.58516539 cgl3784855 PVT1 5820 2 .49478 0.013224485 0.180029638 1.40031736 0.58324929 cgl6619240 LIMA1 51474 2 .49462 0.013230307 0.180029638 1.40037664 0.59832594 cg00354572 FU21963 79611 2 .49429 0.01324254 0.180029638 1.41474587 0.58113151 cg04001668 GPR56 9289 -2 .49419 0.013246208 0.180029638 0.71440649 0.58329972 eg 14187678 TBR1 10716 2 .49384 0.013258919 0.180029638 1.41538934 0.59056071 cg25507001 NME5 8382 2 .49339 0.013275233 0.180029638 1.43248887 0.57291247 cgl2788467 TCF2 6928 2 .49329 0.013278942 0.180029638 1.40712604 0.58314845 cg06456031 FU11000 55281 2 .49316 0.013283625 0.180029638 1.42056962 0.58970351 cg27269917 SLC5A10 125206 -2 .49165 0.013339015 0.180384353 0.71997598 0.59499798 cg04878727 ZNF306 80317 2 .49154 0.01334293 0.180384353 1.41301853 0.57800524 cg06434470 DPP6 1804 -2 .49142 0.013347415 0.180384353 0.70220565 0.56197055 cg21230435 0PN1SW 611 -2 .49133 0.013350637 0.180384353 0.70433102 0.59403994 cg24719601 PH0X2B 8929 2 .49116 0.013356963 0.180384353 1.39873646 0.58773699 cgl2775479 IGSF10 285313 -2 .49071 0.013373344 0.180478119 0.71133929 0.56519766 cg03550002 ARSK 153642 2 .48925 0.013427055 0.180925922 1.39648307 0.58849334 cg08812936 KCNMB2 10242 2 .48903 0.013435376 0.180925922 1.43063808 0.5672146 eg 14254380 WDR63 126820 2 .48877 0.01344502 0.180925922 1.40693535 0.57412263 cgl7853587 NDST3 9348 2 .48857 0.013452193 0.180925922 1.41910507 0.5856192 cgl3952892 SRPR 6734 -2 .48827 0.013463163 0.180925922 0.71001227 0.57492941 cg22821930 RNPC2 9584 2 .48827 0.013463293 0.180925922 1.39177227 0.5734167 cg25139619 C13orf25 407975 2 .48768 0.01348521 0.18105519 1.41228949 0.58854377 cg09273772 T0P2A 7153 2 .48716 0.013504307 0.18105519 1.40700635 0.56900464
cgl4473145 CLEC14A 161198 2.48714 0.013505109 0.18105519 1.4007488 0.59378782 cg01138020 MGC29671 201305 2.48699 0.013510784 0.18105519 1.39260394 0.58546793 cg27402949 FU20097 55610 2.48669 0.013521904 0.181077311 1.39720379 0.59509883 cgl l360718 TM9SF4 9777 -2.48621 0.013539649 0.181148717 0.70878595 0.57971965 cg07974891 ITGB1BP1 9270 -2.48571 0.013558074 0.181148717 0.70399221 0.58738403 cg27274728 CASP6 839 2.48564 0.013560773 0.181148717 1.40594312 0.5744756 cg09448880 PGLYRP3 114771 -2.48553 0.013565127 0.181148717 0.70531009 0.59172045 cgl7858663 C16orf60 55839 2.48507 0.013581887 0.181245954 1.41239824 0.59015732 cgl4159894 BTBD3 22903 2.48444 0.013605686 0.181436928 1.41052534 0.59817467 cg20950277 TNIP3 79931 -2.48406 0.013619922 0.181476391 0.71141084 0.57049213 cg08102619 TIAL1 7073 2.48364 0.013635294 0.181476391 1.40543972 0.58183743 cg25938646 SLITRK1 114798 2.48356 0.01363837 0.181476391 1.4041442 0.59429205 cg01454004 SLC17A5 26503 2.4832 0.013651709 0.181476391 1.40377287 0.58103066 cgl8389810 C14orf8 122664 -2.48296 0.013660906 0.181476391 0.69166921 0.5674163 eg 14659404 ASTN 460 2.48283 0.013665585 0.181476391 1.41455818 0.60372126 cg03593419 GABRA4 2557 2.48246 0.013679747 0.181518643 1.39469401 0.59842679 cg26824091 GLOl 2739 2.48224 0.013687751 0.181518643 1.40126283 0.5736184 cg04662451 RAD51 5888 -2.48069 0.013746056 0.182165514 0.70192479 0.59106495 cg05718625 TMEM85 51234 2.47995 0.013773963 0.182325768 1.41391855 0.58360226 cg20571908 MPHOSPHl 9585 2.47986 0.013777217 0.182325768 1.40234084 0.5849637 cg20832020 VSIG9 201633 -2.4793 0.013798459 0.182410054 0.71155002 0.58103066 cg02946850 GRM8 2918 -2.47913 0.013804886 0.182410054 0.71210251 0.57977007 cg21178548 SAMD14 201191 2.47888 0.01381452 0.182410054 1.40466264 0.58637556 eg 17446142 GDF9 2661 -2.47841 0.013832023 0.182410054 0.70473611 0.56771884 cg24034289 SCAMP3 10067 2.47828 0.0138369 0.182410054 1.43500948 0.56106293 cg06667406 AASS 10157 -2.47807 0.013845167 0.182410054 0.71197252 0.56797096 eg 19867899 PCDHAC2 56134 2.47791 0.013851268 0.182410054 1.40934407 0.58375353 cgl4446712 SDPR 8436 2.47729 0.013874582 0.182410054 1.40824396 0.59414078 cgl0198932 C21orfl29 150135 -2.47706 0.013883491 0.182410054 0.71633052 0.57613957 cg08256027 HYMAI 57061 2.47697 0.013886834 0.182410054 1.4013788 0.58708148 cgl7140815 ATP6V1F 9296 2.47663 0.013899856 0.182410054 1.40598144 0.56671037 cg09658342 TIA1 7072 2.47657 0.013901845 0.182410054 1.41003181 0.5873336 cgl8993334 Clorfl82 128229 2.47622 0.013915109 0.182410054 1.40125746 0.59736789 cg05052633 CENTA2 55803 2.47617 0.013917129 0.182410054 1.40098807 0.5697862 cg08358671 IVNSIABP 10625 2.47528 0.013951041 0.18256556 1.39622097 0.58158532 cg22975712 GALR3 8484 -2.47521 0.01395386 0.18256556 0.70905327 0.58405607 cg04525496 CSPG2 1462 2.47502 0.013960841 0.18256556 1.41182718 0.58158532 cgl9561186 GUCA1C 9626 -2.47453 0.013979888 0.18256556 0.7143934 0.5695593 cg01514487 MYOIA 4640 -2.47446 0.013982578 0.18256556 0.70755821 0.57407221 cg02301754 TMOD4 29765 -2.4743 0.013988687 0.18256556 0.71096161 0.59787213 cgl6034652 KIAA1409 57578 2.47411 0.013995822 0.18256556 1.39203199 0.58360226 cgl7302852 FXR1 8087 2.47333 0.014025503 0.18271396 1.41095374 0.5841065
cg23898073 GFRA1 2674 2.47281 0.01404572 0.18271396 1.40268215 0.59938483 cg09277365 FU90709 153129 2.4727 0.014049787 0.18271396 1.40258541 0.59348528 cg01342792 FAM71A 149647 -2.47268 0.01405074 0.18271396 0.70715675 0.57982049 cg24612198 CD3E 916 -2.47257 0.014054973 0.18271396 0.70091499 0.58385438 cg06501790 SLC34A1 6569 -2.47191 0.014080181 0.182779487 0.7065313 0.55768455 cg24315815 PLSCR4 57088 -2.47175 0.014086222 0.182779487 0.71874016 0.58052642 cg21296602 J0SD3 79101 -2.47141 0.014099475 0.182779487 0.70887823 0.58077854 cgl5309578 PELI1 57162 -2.47064 0.01412907 0.182779487 0.71123669 0.58234167 cg02473123 CD7 924 -2.47047 0.014135577 0.182779487 0.71491389 0.57472771 cgl7838516 MTNR1B 4544 -2.47046 0.014136105 0.182779487 0.71748456 0.56010488 cgl2089169 PRR4 11272 -2.47045 0.014136381 0.182779487 0.70711742 0.58309802 cg20016845 CXXC1 30827 2.47036 0.014140084 0.182779487 1.40066684 0.57992134 cg26643856 HLA-DOA 3111 2.47014 0.014148581 0.182779487 1.40467912 0.58955224 cgl9723473 B3GALT1 8708 -2.46995 0.014155594 0.182779487 0.71000837 0.59444332 cg23599843 JPH1 56704 2.46947 0.01417424 0.182896746 1.38544495 0.57503025 cg08819884 TRNT1 51095 2.4685 0.014212036 0.183235191 1.40520571 0.57835821 cg26258845 ADAM23 8745 2.4683 0.014219633 0.183235191 1.40961218 0.5768455 cg06790862 MPPED2 744 -2.46764 0.014245207 0.18328155 0.7069293 0.56988705 cgl2119029 CDK10 8558 -2.4674 0.014254513 0.18328155 0.71263817 0.58693021 cg21029904 ZNF91 7644 2.46728 0.014259357 0.18328155 1.41608391 0.59908229 cg07463059 IFI16 3428 2.46666 0.014283465 0.18328155 1.4093619 0.60150262 cg24675098 FU23577 79925 2.46631 0.014296944 0.18328155 1.40749423 0.58032473 cg25635316 LOC90693 90693 2.46628 0.014298329 0.18328155 1.4035271 0.58350141 cgl8871276 FU46156 341883 2.46624 0.014299675 0.18328155 1.39948899 0.5866781 cgl3792569 RP13-11B7.1 286464 -2.46624 0.014299906 0.18328155 0.72054992 0.59174566 cgl5831515 ANXA3 306 2.4658 0.014316927 0.18334683 1.39338176 0.59043465 cg01078434 MAS1L 116511 -2.46554 0.014327145 0.18334683 0.70432732 0.57760186 cgl4686321 FU31951 153830 2.4652 0.014340276 0.18334683 1.39121316 0.5794171 cg02844629 ARV1 64801 2.46512 0.01434335 0.18334683 1.38441345 0.58481242 cg08724517 FU21159 79884 2.46443 0.014370623 0.18350787 1.38673925 0.58067769 cg20614736 CCDC74B 91409 -2.46394 0.014389491 0.18350787 0.71824647 0.5672146 cg03426225 FAM38B 63895 -2.46385 0.014393307 0.18350787 0.71394121 0.57729931 cgl3135121 HSPA2 3306 -2.46382 0.014394333 0.18350787 0.71278183 0.60442719 cg23617760 C16orf44 79786 2.4626 0.01444229 0.183996587 1.40641013 0.60543566 cg09059548 PHC1 1911 2.46205 0.014464033 0.184064377 1.40466353 0.58778741 cg01651364 FU23518 79780 2.4619 0.014469736 0.184064377 1.40025309 0.58637556 cg24454579 BIRC8 112401 -2.46121 0.014497248 0.184064377 0.70799817 0.57205526 cgl8953280 TBC1D19 55296 2.46119 0.014497973 0.184064377 1.41345534 0.58224082 cgl0087081 KIAA0355 9710 -2.4611 0.014501582 0.184064377 0.71801462 0.58314845 cg04632683 TFPT 29844 -2.46096 0.014507048 0.184064377 0.70691061 0.56867689 cg21538194 DZIP1L 199221 2.46023 0.014535756 0.184064377 1.38059114 0.58360226 eg 16522484 C14orf49 161176 -2.46005 0.014542903 0.184064377 0.71532316 0.5883925
cg06428195 G0T1 2805 2.4599 0.014548648 0.184064377 1.39688949 0.59540137 cg26431343 HSPC117 51493 -2.45984 0.014551082 0.184064377 0.71362268 0.5655002 cg24249775 KRT10 3858 -2.45956 0.0145622 0.184064377 0.7142026 0.57296289 cg22227058 SLU7 10569 2.45922 0.014575959 0.184064377 1.40192225 0.60356999 cg06507645 SUGT1 10910 2.45911 0.014580299 0.184064377 1.40686284 0.57694635 cgl9797376 TALI 6886 2.45905 0.014582365 0.184064377 1.41045953 0.57573618 cg09607232 MAGEA9 4108 -2.45855 0.014602437 0.18419615 0.70417745 0.5759883 cg02227605 ROPN1L 83853 2.45764 0.014638642 0.184531119 1.42435753 0.58627471 cg04837997 AP3S2 10239 2.45696 0.014665635 0.184554652 1.40938972 0.57608915 cg03491181 FKBP3 2287 2.45688 0.014668719 0.184554652 1.40627844 0.58829165 cg09685747 PNPT1 87178 2.45657 0.014681046 0.184554652 1.39888361 0.58597217 cg00882451 ZP2 7783 -2.45633 0.014690825 0.184554652 0.70575686 0.56968536 cg08137716 TTLL6 284076 -2.45617 0.014697242 0.184554652 0.7170401 0.56852562 cg00627286 UGDH 7358 -2.45602 0.014703349 0.184554652 0.7196457 0.57472771 cg27623214 C19orfl8 147685 -2.4559 0.014708066 0.184554652 0.71414014 0.61345301 cg08615333 TGFB3 7043 -2.45556 0.014721528 0.184589645 0.70783816 0.59172045 cg04088650 UCHL3 7347 2.45535 0.01473016 0.184589645 1.40747863 0.5768455 eg 18885999 CMPK 51727 2.45496 0.014745509 0.184660983 1.38900106 0.5892497 cg00265490 MTDH 92140 2.45428 0.014772727 0.184787851 1.4173829 0.57808088 cg07930578 LTK 4058 -2.45423 0.014774966 0.184787851 0.70723709 0.59111537 cg03954858 FAM83F 113828 -2.45317 0.014817341 0.185120648 0.71949343 0.59403994 cgl2697789 TLR3 7098 2.45308 0.014820937 0.185120648 1.42377362 0.59504841 cg08057475 C15orf21 283651 -2.45259 0.014840669 0.185246119 0.70417171 0.58945139 cg20789691 RLN1 6013 -2.45119 0.014897254 0.185797617 0.7070791 0.57689593 cg08821669 COX6A1 1337 2.45083 0.01491199 0.185797617 1.38560818 0.58698064 cgl2658552 SFRS2IP 9169 -2.45063 0.014919972 0.185797617 0.70962045 0.57538322 cgl2067261 INSL4 3641 -2.45054 0.014923715 0.185797617 0.71642279 0.56393707 cg24759821 PAH 5053 2.45008 0.014942385 0.185909012 1.41719155 0.59141791 cg23521069 SIP1 8487 2.44964 0.014960113 0.18600856 1.41097236 0.58793869 eg 11492856 CAPN7 23473 -2.44911 0.014981636 0.186124197 0.69939498 0.57830779 cg25225073 KCNK13 56659 2.44823 0.015017279 0.186124197 1.40737318 0.57094595 cg01568736 SERPINB7 8710 -2.44806 0.015024401 0.186124197 0.71239747 0.58168616 cg26049501 STARD13 90627 2.44801 0.015026394 0.186124197 1.40114038 0.56681121 cg05593780 PHF5A 84844 2.44772 0.015038071 0.186124197 1.4111217 0.59519968 cg26117431 LRRC39 127495 -2.44762 0.015042178 0.186124197 0.71070881 0.56055869 cgl5865742 SLC31A1 1317 2.44758 0.015044103 0.186124197 1.4082834 0.58783784 cgl4426525 SMPDL3A 10924 2.4475 0.015047277 0.186124197 1.39563558 0.58103066 cgl7169998 MLC1 23209 2.44707 0.015064735 0.186219684 1.40328986 0.56701291 cgl3998293 TRIM63 84676 -2.44594 0.015111097 0.186349428 0.71496022 0.59313231 cg05654163 SLC39A2 29986 -2.44543 0.01513193 0.186349428 0.72364678 0.58269464 cg20070090 S100A8 6279 2.44522 0.01514024 0.186349428 1.40945001 0.56726503 cgl2269343 SEL1L 6400 2.44503 0.01514815 0.186349428 1.41071971 0.5725595
cgl8474135 CDC26 246184 2.44497 0.015150647 0.186349428 1.41207056 0.56373538 cg09251995 JUND 3727 -2.44477 0.015159091 0.186349428 0.71843192 0.57150061 cg09044738 FAM 12A 10876 -2.44418 0.015183303 0.186349428 0.70947543 0.60009076 cgl9843036 FU11155 55314 2.44416 0.015183913 0.186349428 1.39136107 0.60210771 cg25892041 UGT8 7368 -2.44394 0.015192906 0.186349428 0.71387318 0.57155103 cg00396163 FU37357 284944 2.44362 0.015206284 0.186349428 1.40526094 0.58854377 cg27349244 MLXIP 22877 -2.44356 0.015208768 0.186349428 0.7169111 0.58824123 cg l4513226 LPGAT1 9926 2.44346 0.015212917 0.186349428 1.40533511 0.58521581 cg00051623 CAS PI 834 -2.4432 0.015223592 0.186349428 0.69794498 0.57835821 cg02255732 FU46154 196296 -2.44202 0.015272068 0.186349428 0.7163896 0.57487898 cg06254453 HIST1H3F 8968 2.44191 0.015276712 0.186349428 1.38980473 0.59363655 cgl6414945 DUSP12 11266 2.44177 0.015282336 0.186349428 1.40855285 0.58158532 cg04783231 ZFP28 140612 2.44148 0.015294545 0.186349428 1.42517153 0.5901069 cgl8414741 ZNF77 58492 -2.4413 0.015301881 0.186349428 0.71216973 0.5892497 cg27257987 PSG4 5672 -2.44119 0.015306402 0.186349428 0.72190489 0.58980436 cg27458888 UBE3A 7337 2.44105 0.015312307 0.186349428 1.38568606 0.5532977 cg20707333 C20orfl77 63939 -2.44102 0.015313738 0.186349428 0.71478504 0.56761799 cg00332745 NOL3 8996 2.44074 0.015325165 0.186349428 1.38412308 0.58657725 cg07906724 CHRNA6 8973 2.44063 0.015329804 0.186349428 1.41920719 0.58143405 eg 14059475 C2orf34 79823 2.44041 0.015338658 0.186349428 1.39065094 0.58803953 cgl0303487 DPYS 1807 2.4403 0.015343264 0.186349428 1.41893065 0.54855789 cg09149294 ARRDC4 91947 2.44012 0.015350937 0.186349428 1.37852916 0.61546995 cg26937148 NR2F1 7025 2.44009 0.015352066 0.186349428 1.38409912 0.57987092 cgl7468997 NCF1 4687 2.43984 0.015362596 0.186349428 1.37937355 0.59772086 cgl7747005 DEPDC2 80243 2.43973 0.015367109 0.186349428 1.39594813 0.59852763 cg00678539 MNS1 55329 2.4393 0.01538488 0.186349428 1.42521489 0.59414078 cgl3759143 EXPH5 23086 2.43925 0.015387057 0.186349428 1.40310638 0.58677894 cgl9229991 FU22655 79785 -2.4392 0.015389239 0.186349428 0.70420179 0.57160145 eg 18779060 DYRK1A 1859 2.43902 0.01539681 0.186349428 1.39893249 0.56671037 cg25786862 MUT 4594 2.43857 0.015415351 0.186396115 1.41598121 0.59661154 cg04577715 SPINK1 6690 -2.43841 0.01542214 0.186396115 0.71254226 0.58572005 cg24084891 DCC 1630 2.43818 0.015431605 0.186396115 1.38806288 0.58642598 cg20716209 STAT3 6774 2.43799 0.015439656 0.186396115 1.39290613 0.58299718 cgl3042288 ANPEP 290 -2.43772 0.015450834 0.18641337 0.70766741 0.57129891 cg23271318 ZSWIM 1 90204 2.43725 0.015470459 0.186523081 1.40489376 0.57659338 cg27508002 SMAD9 4093 -2.43704 0.015479435 0.186523081 0.71575938 0.56691206 cg08872742 CDH5 1003 2.43653 0.015500668 0.186661309 1.396048 0.58208955 cgl3398993 ARMC1 55156 2.43539 0.015548293 0.187056136 1.38606667 0.58229125 cg21988041 GLT8D2 83468 2.43495 0.015566978 0.187056136 1.39869045 0.59635942 cg02064106 C6orfll8 168090 2.43491 0.015568646 0.187056136 1.40045742 0.56746672 cg05209917 CNTN6 27255 -2.43465 0.015579461 0.187056136 0.70638765 0.59666196 cg09750385 GUCY1A3 2982 2.43458 0.015582364 0.187056136 1.40209491 0.57160145
cgl7266238 C21orf94 246705 -2.43296 0.015650935 0.187474756 0.70814191 0.58340057 cg07612655 PTGIS 5740 2.43252 0.015669225 0.187474756 1.40396218 0.56237394 cgl7709884 H2AFZ 3015 2.43245 0.015672434 0.187474756 1.40203646 0.57951795 cg26829318 GLRX 2745 2.43243 0.01567317 0.187474756 1.39479407 0.57588746 cgl6297030 AGXT2 64902 -2.43237 0.015675618 0.187474756 0.71493404 0.56857604 cg08093398 PSF1 9837 -2.43236 0.015676058 0.187474756 0.71747974 0.56585317 cgl4831798 CDYL 9425 -2.43152 0.015711724 0.187640914 0.71554189 0.59741831 cg04893087 PPARGCIA 10891 2.43126 0.015722669 0.187640914 1.43965432 0.57114764 cg04324308 COL4A3 1285 2.43099 0.015734037 0.187640914 1.40596085 0.58294675 cg08878323 DLX5 1749 2.43094 0.01573609 0.187640914 1.3889551 0.57959359 cg09486093 HSD17B4 3295 2.43071 0.015746132 0.187640914 1.39666234 0.58002219 cg06496654 TAS2R7 50837 -2.43064 0.015748826 0.187640914 0.71469707 0.58521581 cg08338368 IL26 55801 -2.43029 0.015764081 0.187705725 0.71470823 0.58234167 cgl5645605 MRPL35 51318 2.4299 0.015780332 0.187777738 1.42186357 0.58808996 cg21197871 C8orf38 137682 2.42915 0.015812259 0.187777738 1.40274747 0.57866075 cgl7413703 TAF11 6882 2.42895 0.015820844 0.187777738 1.39552899 0.58521581 cgl4341418 APOM 55937 -2.42858 0.015836626 0.187777738 0.72062627 0.57896329 cgl l295113 FOLR2 2350 -2.42811 0.015856987 0.187777738 0.72050411 0.58637556 eg 11884699 OR2A4 79541 -2.42789 0.015866359 0.187777738 0.72100629 0.58524103 cg03813215 BCL2 596 2.42785 0.015867848 0.187777738 1.37564713 0.58602259 cg06281719 GMNN 51053 2.42771 0.015874067 0.187777738 1.41339659 0.57654296 cgl6204757 MSN 4478 -2.4277 0.01587443 0.187777738 0.70131372 0.56766842 cg08949296 JPH1 56704 2.42767 0.015875738 0.187777738 1.39895872 0.58803953 eg 18704595 ADA 100 2.42761 0.015878143 0.187777738 1.39887145 0.58269464 cgl5302379 KAZALD1 81621 2.42717 0.015896825 0.187868339 1.38473075 0.58662767 cg02044879 PLA2G12B 84647 -2.42689 0.015909016 0.187868339 0.71403318 0.58087939 cg23166289 Clorfl07 27042 2.42674 0.015915277 0.187868339 1.38974113 0.58919927 cg26937530 SH3BGRL 6451 2.42532 0.015976259 0.188471839 1.39677653 0.59056071 cgl3620808 UBE2S 27338 2.42463 0.016005882 0.188618255 1.40295423 0.57608915 cg05824215 CCR6 1235 -2.42451 0.016011436 0.188618255 0.7123625 0.57911456 cg02657721 SEMA3B 7869 2.42425 0.016022367 0.188618255 1.40665555 0.56665994 cg27298559 PTRH2 51651 2.42395 0.016035371 0.188618255 1.40126418 0.59403994 cgl3928961 K6IRS3 319101 -2.42347 0.016056246 0.188618255 0.7074872 0.57099637 cg00674922 SATB1 6304 2.423 0.016076459 0.188618255 1.41820601 0.58324929 cg26200585 PRX 57716 2.42286 0.01608271 0.188618255 1.39402701 0.55914683 cgl8222235 FBXW8 26259 2.42277 0.016086555 0.188618255 1.40845276 0.57795482 cgl8195628 MRPL48 51642 2.42276 0.016086685 0.188618255 1.39790396 0.57795482 cg21032583 LMLN 89782 -2.42275 0.016087305 0.188618255 0.70888036 0.57689593 cg24754277 DAPK1 1612 2.42172 0.016131967 0.18901935 1.39958163 0.58082896 cg23683201 SLC22A9 114571 -2.42102 0.016162179 0.18901935 0.70812675 0.56802138 cg25134071 KLK8 11202 -2.42088 0.016168449 0.18901935 0.72403435 0.56393707 cgl4879013 DTWD1 56986 2.42007 0.016203833 0.18901935 1.38953681 0.58435861
cgl6998213 METRN 79006 -2.41978 0.016216133 0.18901935 0.71422765 0.57492941 cg21493666 PPME1 51400 2.41976 0.016217123 0.18901935 1.39320467 0.58728318 cg02186966 BET1 10282 2.41956 0.016225833 0.18901935 1.38655103 0.59172045 cg01637734 CD5L 922 -2.41935 0.016234801 0.18901935 0.71478718 0.57699677 cgl9166875 FER1L3 26509 2.41891 0.016254291 0.18901935 1.40622598 0.57956837 cgl2124478 IQGAP3 128239 2.41885 0.016256697 0.18901935 1.38109375 0.57119806 cg26845278 SPATA21 374955 -2.41872 0.016262607 0.18901935 0.71608479 0.56161759 cgl0367730 PRDX3 10935 2.41867 0.016264848 0.18901935 1.40075664 0.5873336 cgl6173109 FU38379 285097 -2.41856 0.016269644 0.18901935 0.71900747 0.59056071 cg06755819 RCN1 5954 -2.4185 0.01627212 0.18901935 0.70421592 0.58808996 cg06757810 CNGB3 54714 -2.41844 0.016274917 0.18901935 0.71754604 0.57800524 cgl9017193 ZNF161 7716 2.41816 0.016287185 0.18901935 1.37998293 0.58380395 cg01770232 IL6 3569 2.4181 0.016289549 0.18901935 1.40275234 0.59424163 cg07774222 MED6 10001 2.41755 0.016313737 0.189077353 1.3852493 0.56131505 cg06747888 TBR1 10716 2.41754 0.016314323 0.189077353 1.39955691 0.58299718 cgl6195804 FU38663 91574 2.41638 0.01636498 0.189526943 1.3911793 0.57634127 cg20226593 SLC12A1 6557 -2.4162 0.016372937 0.189526943 0.70988037 0.58945139 cg20442697 LRRC17 10234 2.41594 0.016384489 0.189545929 1.37576653 0.58536708 cg04311606 ZNF136 7695 2.4154 0.016408071 0.189558206 1.38108421 0.58566963 cg24977027 FU10916 55258 -2.41538 0.016408918 0.189558206 0.718511 0.5839048 cg01481976 P0LE3 54107 -2.41524 0.016415289 0.189558206 0.71570943 0.59015732 cg20287640 IRF1 3659 2.41464 0.016441822 0.189707542 1.38772896 0.57921541 cg05846716 PCSK2 5126 2.41403 0.0164685 0.189707542 1.39418081 0.57800524 cg21636748 PLEKHA8 84725 2.41401 0.016469338 0.189707542 1.40528258 0.58481242 cgl4079785 SFTPC 6440 -2.41378 0.01647976 0.189707542 0.71858661 0.54870916 cgl9912436 PALM 5064 2.41365 0.016485321 0.189707542 1.38654799 0.56993748 cgl2803724 C8orf70 51101 2.41342 0.016495767 0.189707542 1.39425166 0.58259379 cg26222229 PPIL1 51645 2.41337 0.016497664 0.189707542 1.38417507 0.5672146 cg06628693 PRKACB 5567 2.41294 0.016516673 0.189767966 1.3916277 0.59023296 cg00003994 ME0X2 4223 2.41277 0.016524349 0.189767966 1.39250876 0.58849334 cg00162643 DDX58 23586 2.41238 0.016541704 0.189767966 1.39514647 0.57825736 cg04603184 RNF182 221687 2.41213 0.016552744 0.189767966 1.38232514 0.57644211 cg26815229 CYP2J2 1573 2.41201 0.016558123 0.189767966 1.40011196 0.55057483 cgl l542231 RPA2 6118 2.41191 0.01656246 0.189767966 1.40142216 0.56963493 cgl5707568 ATP5J 522 2.41142 0.016584253 0.189835398 1.40144623 0.59212384 cg22502502 TRIM38 10475 2.41133 0.016588199 0.189835398 1.40181235 0.5665591 cg09527362 C6orfl50 115004 2.41108 0.016599373 0.189849651 1.38695288 0.59666196 cgl7252960 ID4 3400 2.41055 0.01662298 0.190006007 1.37924503 0.55475998 cg25018881 IKBKAP 8518 -2.41028 0.016635198 0.190032076 0.72608537 0.58168616 cg01119135 Clorfll6 79098 -2.40999 0.016648027 0.190065092 0.72449624 0.59151876 cgl5645309 BATF 10538 2.4095 0.016669722 0.190068854 1.40951201 0.57402178 cg25323711 CLGN 1047 2.40943 0.016672858 0.190068854 1.39147853 0.57336628
cgl4167596 MSX1 4487 2.40896 0.016694126 0.190068854 1.38914582 0.56544978 cg04483754 NOS2A 4843 -2.40878 0.016702105 0.190068854 0.71691659 0.58798911 cg01862366 TMEM20 159371 2.40873 0.016704299 0.190068854 1.37569234 0.56948366 cg24147596 ARL14 80117 -2.40862 0.01670894 0.190068854 0.71882478 0.58849334 cg09572685 MKS1 54903 -2.40842 0.016717932 0.190068854 0.72066475 0.57571097 cg00979348 HPSE 10855 2.40785 0.016743599 0.190238032 1.37620808 0.55859217 cgl2991341 TMEM74 157753 -2.40765 0.016752708 0.190238032 0.71301818 0.58294675 cg25943702 BRD1 23774 -2.40724 0.016770811 0.190330576 0.72505407 0.58629992 cg02300906 FANCF 2188 2.40593 0.016830054 0.190676326 1.39497865 0.57845906 cg00629217 LNX1 84708 -2.40585 0.01683337 0.190676326 0.71170818 0.57503025 cg20010565 FU37953 129450 2.40569 0.016840704 0.190676326 1.39590837 0.57699677 cg07846220 LAMA1 284217 2.40559 0.016845216 0.190676326 1.38237411 0.56797096 cg24777065 FBLN5 10516 2.4051 0.016867456 0.190676326 1.38017585 0.5866781 cg01214847 TMPRSS3 64699 -2.40479 0.016881383 0.190676326 0.72012926 0.59293062 cg22294908 ZHX3 23051 -2.40478 0.016881721 0.190676326 0.7176922 0.57492941 cgl8113787 CRSP6 9440 2.40455 0.016892107 0.190676326 1.3762998 0.59282977 cgl2581035 PHC1 1911 2.40439 0.016899334 0.190676326 1.3866867 0.56630698 cgl9481811 UGT2B17 7367 -2.4042 0.016907835 0.190676326 0.72735269 0.57951795 cg20853593 DNPEP 23549 2.40408 0.016913431 0.190676326 1.40259832 0.58425777 cg00899641 SF3B1 23451 2.40391 0.01692093 0.190676326 1.41288467 0.56766842 cg09848074 FU44186 346689 2.4034 0.016944078 0.190824735 1.38708131 0.58587132 cg24777950 CTSG 1511 2.40287 0.016968194 0.190983852 1.39349839 0.59308189 cg26333317 METTL7A 25840 2.40188 0.01701334 0.191090328 1.38986471 0.57291247 cg05961827 UGT1A7 54577 -2.40177 0.017018049 0.191090328 0.71128953 0.58708148 cg00919857 TMOD2 29767 -2.40174 0.017019395 0.191090328 0.72246854 0.57195442 cg23741330 C6orfl88 254228 -2.4017 0.017021362 0.191090328 0.71781086 0.57024002 cgl7920197 LGI4 163175 -2.40141 0.017034395 0.191090328 0.71272391 0.58516539 cgl3467814 C2orf30 27248 2.40116 0.017046178 0.191090328 1.39084941 0.58007261 cg02584520 STAU2 27067 2.40112 0.017047603 0.191090328 1.3698414 0.56867689 cg01724150 NMNAT3 349565 2.40059 0.017071894 0.191097646 1.38906322 0.56706333 cg00059225 GLRA1 2741 -2.4005 0.017075844 0.191097646 0.72038432 0.57558491 cg22997415 OVGP1 5016 -2.40045 0.017078235 0.191097646 0.72254425 0.56358411 cgl4602578 CASP8AP2 9994 2.40008 0.0170953 0.191176721 1.38568972 0.57886245 eg 16404689 Clorfl56 92342 2.39939 0.017126666 0.191415551 1.39447406 0.57881202 cg00397740 PPOX 5498 2.39917 0.017136776 0.191416674 1.38611446 0.56923155 cg06815817 ZNF212 7988 2.3982 0.017181253 0.191640796 1.39418315 0.57039129 cg24286767 LOC51255 51255 2.39787 0.017196315 0.191640796 1.39655291 0.57523195 cg02360776 ZBTB3 79842 2.39786 0.017196655 0.191640796 1.39602041 0.55934853 cgl2265604 HAS3 3038 2.39786 0.017196927 0.191640796 1.39051354 0.57583703 cg24936630 DDX10 1662 2.39733 0.017221416 0.1916956 1.39830961 0.5777027 cgl0167296 RASSF5 83593 2.39662 0.01725403 0.1916956 1.38798716 0.56242437 cg07535879 MTRF1L 54516 2.39656 0.017256406 0.1916956 1.37738623 0.5785599
cgl0272885 SNAPAP 23557 2.39612 0.01727694 0.1916956 1.39033432 0.5969645 cgl l626656 RND3 390 2.39551 0.017305107 0.1916956 1.39554832 0.56711376 cg01057962 BCL6 604 2.39525 0.017317042 0.1916956 1.38861659 0.60104881 cg25119415 MNDA 4332 -2.39512 0.017323069 0.1916956 0.71608239 0.5881908 cg05593300 PRRX1 5396 2.39504 0.017326691 0.1916956 1.38285222 0.59023296 cg26053787 PRPS1 5631 -2.39504 0.017326839 0.1916956 0.72571295 0.58642598 cg04916311 PQLC3 130814 2.3949 0.017333144 0.1916956 1.38895196 0.57553449 cgl5560337 HYAL4 23553 -2.39482 0.017336874 0.1916956 0.72181154 0.5830476 cg25723866 LTBP4 8425 -2.39481 0.017337493 0.1916956 0.70820675 0.5943929 cg26918442 LCMT2 9836 2.39478 0.017338784 0.1916956 1.38317546 0.57820694 cg21892409 Cllorf49 79096 2.39426 0.017362929 0.1916956 1.39656683 0.58546793 cgl2234947 GNAT2 2780 -2.3941 0.017370275 0.1916956 0.7153632 0.58365268 cgl6606638 GALNT4 8693 2.39397 0.017376396 0.1916956 1.3748835 0.5717023 eg 10269439 IL1F7 27178 -2.39352 0.017396881 0.1916956 0.72939647 0.56797096 cgl5143643 FBLN1 2192 -2.39351 0.017397353 0.1916956 0.71645428 0.58319887 cg05193832 KCNJ1 3758 -2.39343 0.017401281 0.1916956 0.71827146 0.58329972 cgl2266024 DRCTNNBIA 84668 2.39337 0.017404142 0.1916956 1.37894475 0.57840863 cg05404787 FU25102 348738 -2.39319 0.017412357 0.1916956 0.71611309 0.57689593 cg07356753 GBE1 2632 2.39227 0.017455352 0.192058371 1.37442286 0.62237798 cg22231902 EN1 2019 2.39123 0.017503357 0.192075555 1.39436373 0.57195442 cg07918509 ICAM2 3384 -2.39096 0.017516118 0.192075555 0.73166891 0.57775313 cg04520391 PRB2 440083 -2.39053 0.017536133 0.192075555 0.71508247 0.5901069 cg23615676 KCNN2 3781 2.39022 0.017550694 0.192075555 1.39147342 0.59419121 cg24247865 CHORDCl 26973 2.38989 0.017566178 0.192075555 1.382556 0.59393909 cgl2654845 CLDN2 9075 -2.38972 0.017573911 0.192075555 0.71384787 0.57407221 cg22227689 SCPEP1 59342 2.38957 0.017581128 0.192075555 1.37633391 0.57825736 cg08130265 C15orf5 81698 2.38936 0.017591014 0.192075555 1.39036713 0.57850948 cg06878726 RBM 19 9904 2.38915 0.017600748 0.192075555 1.37656371 0.58657725 cg00499599 MCM3AP 8888 2.38898 0.017608707 0.192075555 1.38909849 0.58128278 cgl7199658 MGC39715 169166 -2.38885 0.01761473 0.192075555 0.7184235 0.5785599 cgl l706163 C9 735 -2.38864 0.01762459 0.192075555 0.71956058 0.57634127 cgl6122592 MAGEB6 158809 -2.38821 0.017644777 0.192075555 0.72719846 0.59323316 cgl l765205 ARL11 115761 2.38782 0.017663226 0.192075555 1.38483412 0.56650867 cg24616736 HDAC6 10013 2.38778 0.017665169 0.192075555 1.37519776 0.59363655 cg27514224 NUP188 23511 -2.38772 0.017667807 0.192075555 0.71954376 0.57916499 cg00850538 CRIM 1 51232 -2.38768 0.017669842 0.192075555 0.72049413 0.57573618 cgl4306534 ZBTB2 57621 2.38745 0.0176808 0.192075555 1.39340748 0.57729931 cgl7142149 DSCR1L1 10231 -2.38729 0.017688035 0.192075555 0.72321557 0.5830476 cg09778422 MSN 4478 -2.38698 0.017702745 0.192075555 0.72609512 0.57039129 cg04336572 ATP1B4 23439 -2.38695 0.017704186 0.192075555 0.71943103 0.57180315 cgl9028160 HDAC4 9759 -2.38654 0.017723572 0.192075555 0.72854884 0.56877773 cg04884122 PSMB5 5693 2.3865 0.017725241 0.192075555 1.38985769 0.57971965
cg20546002 COL23A1 91522 2.38646 0.017727207 0.192075555 1.37776967 0.58269464 cg07900766 SPAG16 79582 2.38619 0.017739982 0.192075555 1.39905131 0.589048 cgl5836660 EDNRB 1910 2.38607 0.017745392 0.192075555 1.40474312 0.59661154 cgl8501026 DOCK3 1795 2.38585 0.017756054 0.192075555 1.36910233 0.56691206 cg25650811 LOC223075 223075 -2.38566 0.017764811 0.192075555 0.71192184 0.58123235 cg21663122 HIST1H2BH 8345 2.38566 0.017765 0.192075555 1.405816 0.60387253 cg04058675 HUWE1 10075 -2.38563 0.017766374 0.192075555 0.7208806 0.57503025 cgl3162577 Cllorf42 160298 -2.38559 0.017768286 0.192075555 0.71754179 0.57586224 cg02671171 RPH3AL 9501 -2.38484 0.017803837 0.19224483 0.72853363 0.58118193 cgl9318511 C9orf30 91283 2.38481 0.017805344 0.19224483 1.4075833 0.5849637 cg07411229 LOC128153 128153 2.38462 0.017814104 0.19224483 1.39085625 0.57074425 cgl0692870 FN1 2335 2.38398 0.017844653 0.192465888 1.38971159 0.57442517 cgl ll87508 CWF19L1 55280 2.38342 0.017870893 0.192640258 1.39428692 0.57992134 cg04702045 OPHN1 4983 -2.38304 0.017889306 0.192730095 0.72378652 0.56676079 cg02883161 MSI1 4440 2.38253 0.017913273 0.192800465 1.38723227 0.56958451 eg 19706602 MGMT 4255 2.38247 0.017916002 0.192800465 1.3779427 0.57286204 cg20334738 MAB21L2 10586 -2.38212 0.017932929 0.192815378 0.7162851 0.58909843 cg02094237 HIST4H4 121504 2.38175 0.017950457 0.192815378 1.38426136 0.57755143 cg05749792 DGAT2L6 347516 -2.38148 0.017963543 0.192815378 0.72139026 0.57878681 cgl2428604 TMEM60 85025 2.38121 0.017976284 0.192815378 1.3785217 0.59862848 eg 14474880 MTF2 22823 2.38112 0.017980638 0.192815378 1.37125619 0.57689593 cg01968530 C18orf45 85019 2.38094 0.017989225 0.192815378 1.38920119 0.58052642 cg08109646 ZNF683 257101 -2.38078 0.017996583 0.192815378 0.72205008 0.56887858 cg24896109 CYP51A1 1595 2.38075 0.017998051 0.192815378 1.37797854 0.58607301 cgl5582891 TAAR1 134864 -2.37985 0.01804129 0.192844085 0.72754747 0.58360226 cgl6711185 SHC4 399694 2.37949 0.018058613 0.192844085 1.3981809 0.58148447 cgl6377880 CYP4F3 4051 -2.37944 0.018060703 0.192844085 0.72837914 0.57422348 cg06166863 PNN 5411 2.3794 0.018062748 0.192844085 1.37942313 0.57472771 eg 19848683 EVI1 2122 2.37903 0.018080722 0.192844085 1.39135629 0.58234167 cg26565975 KRTAP20-1 337975 -2.37862 0.018100279 0.192844085 0.71816051 0.57840863 cg06263495 ASCL2 430 2.37845 0.018108546 0.192844085 1.38202313 0.57134933 cgl0893007 NBR2 10230 2.37832 0.018114482 0.192844085 1.40518355 0.57462687 cgl7398613 SLC37A1 54020 2.3783 0.018115499 0.192844085 1.38006108 0.5785599 cg04451770 ENTPD1 953 2.37823 0.018119099 0.192844085 1.3993703 0.5860478 eg 15604467 POU4F1 5457 2.37808 0.018126334 0.192844085 1.37477908 0.58884631 cg26256793 COL11A1 1301 2.378 0.018129907 0.192844085 1.37775176 0.57624042 cgl4081015 RIOK2 55781 2.37778 0.018140479 0.192844085 1.39028363 0.57624042 cg23428445 GPR37 2861 2.37749 0.018154699 0.192844085 1.38340763 0.5875353 cg23974202 CCNT2 905 2.37699 0.018178591 0.192844085 1.38556581 0.58042558 cg22659426 CLN3 1201 2.37661 0.01819703 0.192844085 1.3730036 0.58128278 cgl4145762 FU10726 55216 2.37634 0.018210001 0.192844085 1.39330691 0.58385438 cgl5559700 UGT1A9 54600 -2.3763 0.018212156 0.192844085 0.71532677 0.57119806
cg00195561 CHRM4 1132 -2.37592 0.018230171 0.192844085 0.72230683 0.57452602 eg 11128808 CACNG6 59285 2.37578 0.018237292 0.192844085 1.38889399 0.56494554 cg05221167 ZNF560 147741 2.37559 0.018246139 0.192844085 1.3888861 0.57982049 cg20123891 NXPH3 11248 2.37542 0.018254501 0.192844085 1.37705928 0.580476 cgl7714799 CASP6 839 2.37488 0.018280512 0.192844085 1.38102065 0.58415692 cg20622056 SLC7A3 84889 -2.37473 0.01828788 0.192844085 0.7246222 0.56307987 cg22971191 SLC10A2 6555 -2.37466 0.018291193 0.192844085 0.71910798 0.59530052 cg09033997 CCR9 10803 -2.37434 0.018306604 0.192844085 0.7162526 0.568929 cgl2126248 NDUFA5 4698 2.37417 0.018314978 0.192844085 1.38836509 0.58042558 cgl8581445 SHD 56961 2.37403 0.018322026 0.192844085 1.37473058 0.57129891 cgl0236239 SULT1C2 27233 2.37398 0.018324511 0.192844085 1.40462516 0.58687979 eg 18644543 HMHA1 23526 -2.3738 0.018333031 0.192844085 0.72452749 0.59227511 cg06567342 ZNF265 9406 2.37354 0.018345825 0.192844085 1.38030795 0.58002219 cg07331725 SERPINB5 5268 -2.37346 0.018349417 0.192844085 0.71565244 0.56328157 cgl8504532 RABGAPIL 9910 2.3734 0.018352529 0.192844085 1.39079045 0.57871117 cg23231873 USP32 84669 2.37328 0.018358191 0.192844085 1.3797638 0.5926785 cg03417466 TYR 7299 -2.37314 0.018364962 0.192844085 0.72077044 0.56708854 cgl6360372 SPINK1 6690 -2.37293 0.018375354 0.192844085 0.71216302 0.58824123 eg 19706682 LRRC50 123872 2.37283 0.018380224 0.192844085 1.37540491 0.55980234 cg26670626 ZKSCAN1 7586 -2.37256 0.018393271 0.192844085 0.72769869 0.56010488 cg26683005 CARD8 22900 2.37243 0.018399484 0.192844085 1.38744714 0.58662767 cg01532771 CLEC4M 10332 -2.37234 0.018404109 0.192844085 0.71190339 0.57069383 cgl0217449 GNPDA2 132789 2.37181 0.018429686 0.19288662 1.38901314 0.58380395 cg24053587 PTPRO 5800 2.37179 0.018430739 0.19288662 1.38722487 0.58450988 cgl2866859 HEXIM1 10614 2.37164 0.018438428 0.19288662 1.38154422 0.5858209 cg06018072 CLN6 54982 2.37142 0.01844905 0.192892219 1.38627464 0.58365268 cgl2815841 LHPP 64077 -2.371 0.018469252 0.192944167 0.7271304 0.56983663 cgl5526708 TGFBR1 7046 2.3709 0.018474198 0.192944167 1.371202 0.58506454 cgl7770886 ZNF511 118472 2.37026 0.018505606 0.193091175 1.38959818 0.57407221 cg24748945 MAP2K2 5605 2.3702 0.018508469 0.193091175 1.37086441 0.59570391 cg23097681 ARHGAP24 83478 2.36916 0.018559498 0.193450854 1.38287078 0.58002219 cg21270015 HDCMA18P 51574 -2.36889 0.01857285 0.193450854 0.72344016 0.57815652 cg06034822 USF1 7391 2.36888 0.018573294 0.193450854 1.4028585 0.56802138 cg00520708 FU37562 134553 2.36867 0.018583661 0.19345347 1.39195788 0.580476 cg07472159 COL10A1 1300 -2.36784 0.018624341 0.193717681 0.72390615 0.59106495 cgl3705284 ACOX2 8309 -2.36743 0.018644905 0.193717681 0.72143583 0.5586426 cg00043080 PLD3 23646 -2.36721 0.018655724 0.193717681 0.71990594 0.58077854 cgl2182525 ASB5 140458 -2.3671 0.018661081 0.193717681 0.71932255 0.584762 cg20402382 APEH 327 2.36675 0.018678268 0.193717681 1.39104756 0.5665591 cgl6009558 GRIK2 2898 2.36619 0.018705838 0.193717681 1.38374061 0.60639371 cgl2683929 BLOC1S1 2647 2.36618 0.018706294 0.193717681 1.38939132 0.58037515 cgl4023558 HNRPA3 220988 2.36616 0.018707262 0.193717681 1.3849359 0.57755143
cg21817450 PIG38 55068 -2.36611 0.018709988 0.193717681 0.71362851 0.55786103 cg02115041 NPBWR1 2831 2.36585 0.018722749 0.193717681 1.36438313 0.62520169 cgl4258236 OR5V1 81696 -2.36577 0.018726934 0.193717681 0.7137469 0.58380395 cgl2315302 HIST1H4D 8360 2.36569 0.018730603 0.193717681 1.38642301 0.56958451 cgl8328190 C3orf35 339883 -2.36519 0.018755248 0.193742055 0.72207118 0.56144111 cg24362401 PIK3C3 5289 2.36507 0.018761193 0.193742055 1.38629445 0.59192215 cg26790059 MGC27121 408263 -2.36481 0.018774133 0.193742055 0.71809729 0.58985478 cg01931893 TK2 7084 2.36444 0.018792824 0.193742055 1.3797282 0.57694635 cg08455548 PCDH11Y 83259 2.36435 0.018796838 0.193742055 1.38596398 0.59333401 cg21875234 GSPT1 2935 -2.364 0.018814674 0.193742055 0.72666307 0.56781969 cg24116886 DEFB127 140850 -2.36372 0.018828569 0.193742055 0.71902638 0.57003832 cgl7991347 MAGED1 9500 2.36362 0.018833264 0.193742055 1.38374748 0.59247681 cg01439983 PEX13 5194 2.36335 0.018846854 0.193742055 1.38392698 0.57906414 cg07974303 DEFA6 1671 -2.36332 0.018848148 0.193742055 0.71682856 0.56287818 cg27170298 BCS1L 617 2.3631 0.01885913 0.193742055 1.38274327 0.57528237 cgl9307060 FAM 10A4 145165 -2.36269 0.018879774 0.193742055 0.72778248 0.57795482 cg07807817 C14orf44 145483 2.36262 0.018883024 0.193742055 1.40084229 0.56010488 cg21930712 FU40235 284369 -2.36207 0.018910808 0.193742055 0.71869914 0.56973578 cg27226949 EFNB2 1948 -2.36206 0.018910922 0.193742055 0.72746369 0.58889673 cg08251036 MGAT5 4249 -2.36199 0.018914649 0.193742055 0.71558955 0.56575232 cgl5810326 LOC90826 90826 2.36188 0.018920196 0.193742055 1.38247604 0.5779044 eg 11044823 PPWD1 23398 2.36164 0.018931837 0.193742055 1.37461928 0.57608915 cgl5873715 DAB2 1601 2.36147 0.018940525 0.193742055 1.38053966 0.57613957 cgl6176600 FRK 2444 -2.36145 0.018941442 0.193742055 0.71645097 0.55652481 cg25219134 IQWD1 55827 2.36137 0.01894572 0.193742055 1.3984333 0.59005647 cg27377450 ARHGEF18 23370 -2.35956 0.019036208 0.194466954 0.72219789 0.58082896 cg23414431 CAPN3 825 -2.35948 0.019040443 0.194466954 0.71654769 0.57311416 cg23889093 EIF1 10209 2.35934 0.019047114 0.194466954 1.3885588 0.57881202 cg25344639 SEC14L1 6397 2.35912 0.019058478 0.194479145 1.38092652 0.58456031 cg05413282 PRSS3 5646 -2.35858 0.019085298 0.194543161 0.72147201 0.56202098 cg05246522 KSR1 8844 -2.35822 0.019103757 0.194543161 0.7242382 0.53822106 cg22816171 DDX50 79009 2.35793 0.019118059 0.194543161 1.37048578 0.57629084 eg 15844609 YIF1B 90522 -2.35776 0.01912686 0.194543161 0.72391784 0.60372126 cg24697329 ARHGEF4 50649 -2.3576 0.019134698 0.194543161 0.73082591 0.54618798 cg06192753 GADD45GIP1 90480 2.3575 0.019140016 0.194543161 1.37880865 0.59161961 cg26222407 STAG 2 10735 -2.35734 0.019147806 0.194543161 0.72801799 0.57497983 cgl2145907 PCDHGC4 56098 2.35733 0.019148479 0.194543161 1.37949005 0.59121622 cg03535648 PMCH 5367 -2.35703 0.019163663 0.194543161 0.72396974 0.57392094 cg06833562 Clorfl81 54680 2.35692 0.019169016 0.194543161 1.38200068 0.58566963 cg06279414 TRIP11 9321 2.35677 0.019176658 0.194543161 1.39223752 0.57271077 cg07044282 ANGPTL1 9068 -2.35622 0.019204768 0.194725028 0.71716838 0.57926583 cgl3514129 MACF1 23499 2.35529 0.019251721 0.194970359 1.37542242 0.58324929
cgl8870231 Clorf87 127795 -2.35528 0.019251898 0.194970359 0.7173382 0.58188786 cgl l286122 PHLDB1 23187 -2.35513 0.019259551 0.194970359 0.72556365 0.56358411 cg06060661 MAGEA11 4110 2.35464 0.019284633 0.195069806 1.37710867 0.57281162 cg00629585 GFI1B 8328 2.35454 0.019289776 0.195069806 1.39763198 0.57845906 cg04887278 RWDD2 112611 2.35408 0.019312989 0.195201331 1.36918801 0.60599032 cgl8201198 FU33708 285780 -2.35333 0.01935139 0.195472774 0.71952592 0.57810609 cg21669679 DCC 1630 2.35307 0.019364437 0.195472774 1.37384205 0.57326543 cgl9302283 BTC 685 -2.35295 0.019370511 0.195472774 0.72630351 0.57074425 cg20353465 ABHD1 84696 2.35232 0.019402945 0.19548143 1.3813872 0.57029044 eg 14260458 OCM 4951 -2.35222 0.019407856 0.19548143 0.72012671 0.57346712 cg06872381 DPPA3 359787 -2.3516 0.019439654 0.19548143 0.7202521 0.57366882 eg 14426682 MORF4L1 10933 -2.3514 0.019449951 0.19548143 0.71261696 0.57563534 cgl5083233 AKAP2 11217 2.35139 0.019450302 0.19548143 1.38641593 0.56595401 cgl7624892 HMGN4 10473 2.35139 0.019450352 0.19548143 1.38833874 0.56943324 cg22646710 SYT6 148281 2.35125 0.019457317 0.19548143 1.37877967 0.59847721 cg04677163 CAV1 857 2.35119 0.019460352 0.19548143 1.38001842 0.59797297 cg06275635 PGLYRP3 114771 -2.35111 0.01946448 0.19548143 0.72864104 0.58143405 cg27440834 SNX4 8723 -2.35055 0.019493452 0.19548143 0.71805319 0.56076039 cg26073856 FABP2 2169 -2.35055 0.019493531 0.19548143 0.72785034 0.58866983 cg01726767 LALBA 3906 -2.35018 0.019512408 0.19548143 0.72158847 0.59227511 cgl3463167 FU20054 54530 -2.35 0.019521627 0.19548143 0.72535637 0.59363655 cg26091688 ZNF200 7752 2.35 0.019521655 0.19548143 1.38620695 0.58607301 eg 14602658 TMEM39A 55254 2.3499 0.019526508 0.19548143 1.36750119 0.58440904 cg05399553 SNRPB 6628 2.34964 0.019539948 0.19548143 1.39706591 0.58017346 cg20506766 MFN1 55669 2.34935 0.019554848 0.19548143 1.37455536 0.59172045 cg02021817 RBL2 5934 2.34916 0.019564691 0.19548143 1.38830915 0.58143405 cgl0608333 HIST1 H4K 8362 2.34914 0.019565594 0.19548143 1.37920158 0.57180315 cgl l388238 KCTD18 130535 2.34872 0.019587197 0.195499732 1.37043216 0.57926583 cg08158860 RAD51L1 5890 2.34838 0.019604823 0.195499732 1.39670771 0.568929 cg26277809 M6PR 4074 2.34832 0.019607954 0.195499732 1.38386134 0.59474587 cgl4698961 LOC129285 129285 2.34831 0.019608319 0.195499732 1.38515693 0.56822307 cgl3904771 C10orf47 254427 2.3475 0.019650015 0.195524562 1.35822044 0.59025817 cg08308257 SMNDC1 10285 2.34739 0.019655782 0.195524562 1.38900301 0.59514925 cg24926780 OR10H2 26538 2.34711 0.019670398 0.195524562 1.35662703 0.5796188 cgl4184817 XTP7 90332 2.34703 0.019674561 0.195524562 1.38646085 0.57866075 cg20109151 NIPSNAP3A 25934 2.34679 0.01968686 0.195524562 1.38542499 0.56489512 cg08996986 EPS8L1 54869 -2.34659 0.019697157 0.195524562 0.71751519 0.58450988 cg03365354 MCAM 4162 -2.34642 0.01970609 0.195524562 0.72606981 0.57099637 cg09445097 ZNF79 7633 2.34639 0.019707418 0.195524562 1.37675251 0.59035902 cg06189133 INSL3 3640 2.34639 0.019707612 0.195524562 1.3817071 0.56237394 eg 19789466 OAS1 4938 2.34589 0.019733513 0.195524562 1.41024289 0.57311416 cg05697976 MLSTD1 55711 2.34575 0.019740555 0.195524562 1.37766407 0.60024203
cg08750326 ODZ1 10178 2.34572 0.019742291 0.195524562 1.36464387 0.57462687 cgl l353032 U2AF1L2 8233 2.34552 0.01975251 0.195524562 1.36725666 0.59051029 cg20433014 CYP1A1 1543 2.34545 0.019756384 0.195524562 1.39514987 0.57104679 eg 10586599 ORC1L 4998 2.3453 0.019764179 0.195524562 1.38907973 0.58254336 cgl2840719 CDKN2A 1029 2.3451 0.019774525 0.195525767 1.3849276 0.57578661 cg01703884 FU37587 283446 -2.3444 0.019810967 0.195605847 0.72784431 0.56141589 cgl4543592 MYBPC2 4606 -2.34433 0.019814619 0.195605847 0.73347892 0.59514925 cg23984130 IGKV7-3 28905 -2.34424 0.019818845 0.195605847 0.72030237 0.58572005 cg09088577 OTUD4 54726 -2.34407 0.019827871 0.195605847 0.72049992 0.5841065 cgl2417466 ARPP-21 10777 -2.34396 0.019833769 0.195605847 0.7283117 0.57634127 cgl7989572 RAB5C 5878 -2.3431 0.019878235 0.195879237 0.73117753 0.57709762 cg22126032 CAV1 857 2.34303 0.019881976 0.195879237 1.39914201 0.55107906 cg08383315 RIC3 79608 2.34238 0.019916154 0.195984102 1.36817181 0.60019161 cg05732130 FU13912 64785 2.34212 0.019929624 0.195984102 1.38356735 0.58471158 cg26583078 SORBS2 8470 -2.34205 0.019933309 0.195984102 0.72056147 0.56797096 cg23280339 PQBP1 10084 -2.34167 0.01995338 0.195984102 0.72143011 0.57407221 cg05300132 EXDL2 55218 -2.34139 0.019967843 0.195984102 0.72347394 0.56832392 cg08108641 NTNG2 84628 -2.34127 0.019974031 0.195984102 0.72481272 0.58067769 cgl6940935 ACS Ml 116285 -2.34097 0.01998958 0.195984102 0.7078998 0.58723276 cgl6398289 WDR49 151790 -2.34087 0.019994807 0.195984102 0.73260241 0.56418919 cgl2832565 CD160 11126 -2.34077 0.020000245 0.195984102 0.73091858 0.58062727 cgl8411891 FZD4 8322 2.34069 0.020004491 0.195984102 1.39174563 0.56489512 cgl0442358 HRBL 3268 2.34067 0.020005355 0.195984102 1.37090001 0.580476 cg06730286 IFT140 9742 -2.34032 0.020023899 0.196065328 0.73003816 0.56696249 cgl9859270 GPR15 2838 -2.33942 0.020071331 0.196429187 0.72626069 0.58087939
DKFZP564O0
cgl l298412 823 25849 2.33892 0.020097375 0.196583461 1.37261492 0.57003832 cg22643217 KRTAPll-1 337880 -2.33651 0.02022489 0.197705844 0.73073291 0.5657019 egl 1110686 MAGEC1 9947 2.33565 0.020270171 0.197705844 1.36357285 0.58178701 cgl9868730 POPDC2 64091 -2.33565 0.020270459 0.197705844 0.72905723 0.57750101 cg06677140 MSX1 4487 -2.33556 0.020274849 0.197705844 0.71947468 0.58294675 cgl7836145 VNN2 8875 2.33556 0.02027505 0.197705844 1.39826952 0.57740016 cg21721155 HADHSC 3033 2.3354 0.020283748 0.197705844 1.36712112 0.5849637 cgl9319069 UBE2H 7328 2.33538 0.020284491 0.197705844 1.38117095 0.57619 cg05018361 NSUN6 221078 2.33495 0.020307648 0.197808857 1.37175844 0.58203913 cg00845900 CPA4 51200 -2.33479 0.020315748 0.197808857 0.72010797 0.57119806 cg02602864 MAP2K6 5608 2.33406 0.020354891 0.198089123 1.39132802 0.57805567 cg25173010 TXNIP 10628 2.33319 0.020401305 0.198278521 1.37545886 0.55624748 cgl5186584 C9orf24 84688 -2.33318 0.020401812 0.198278521 0.72924043 0.58375353 cgl l657808 RYR2 6262 2.33278 0.020423035 0.198278521 1.36573614 0.57114764 cgl5781625 UCK2 7371 2.33258 0.020433668 0.198278521 1.38061254 0.59177088 cgl9862344 RHAG 6005 -2.33252 0.020436722 0.198278521 0.73010138 0.58173659
eg 18344063 MGAT4C 25834 -2.33235 0.020445831 0.198278521 0.72174443 0.57210569 cgl8350391 IL32 9235 2.33233 0.020446933 0. 198278521 1.3671982 0.59605688 cg22416721 DMP1 1758 -2.33206 0.020461548 0. 198319673 0.72660195 0.57331585 cg05396987 FU30834 132332 2.33151 0.020491117 0. 198505657 1.36352059 0.56948366 cg09234872 TRAF7 84231 2.33044 0.020548087 0. 198956099 1.37316462 0.5751311 cg04691540 ABL2 27 2.33013 0.020565226 0. 198956099 1.35951837 0.56348326 cg24653967 PRH 1 5554 -2.33006 0.020568827 0. 198956099 0.71802056 0.59172045 cg27589921 CIAPIN1 57019 -2.32939 0.0206048 0. 199132985 0.72415261 0.57134933 cgl4251536 C20orf6 51575 2.3293 0.020609494 0. 199132985 1.38583934 0.57740016 cg06938406 COX6A1 1337 2.32903 0.020624359 0. 199132985 1.37435556 0.57634127 cgl5642326 MARK4 57787 -2.32894 0.020628767 0. 199132985 0.72684588 0.58360226 cgl2111714 ATP8A2 51761 2.3284 0.020658007 0. 199270318 1.36326786 0.58420734 cgl5661409 C14orfl05 55195 -2.32812 0.020673376 0. 199270318 0.72261784 0.59923356 cg08612871 GJB5 2709 -2.32801 0.020678903 0. 199270318 0.72592367 0.56988705 cg21324308 PROK1 84432 -2.3278 0.020690682 0. 199270318 0.72350229 0.57523195 eg 19982860 IFNA21 3452 -2.32755 0.020704205 0. 199270318 0.7222146 0.57523195 cg22153481 PRKAG1 5571 2.32752 0.020705517 0. 199270318 1.3613461 0.58103066 eg 19358442 ALX4 60529 2.32721 0.02072262 0. 199293882 1.37802714 0.5674163 cgl7475456 CLEC2B 9976 2.32709 0.020728809 0. 199293882 1.37702894 0.58612344 cgl2621514 DKK1 22943 2.32654 0.020758632 0. 199480321 1.36540173 0.57480335 cgl0578779 ZBTB37 84614 2.32626 0.020773746 0. 199525296 1.38608957 0.56676079 eg 11640565 STS 412 -2.32581 0.020798308 0.19966092 0.72483005 0.5841065 cg21644826 ACSM3 6296 2.32538 0.020821444 0. 199737066 1.38673916 0.58385438 cgl2853521 MC5R 4161 2.32492 0.020846664 0. 199737066 1.38050864 0.57210569 cgl7319849 GBA 2629 2.32478 0.020853943 0. 199737066 1.38066298 0.59121622 cgl2785689 ITGB4BP 3692 2.32478 0.020854212 0. 199737066 1.36129321 0.59282977 cg20644453 C21orf59 56683 2.3247 0.020858464 0. 199737066 1.37178456 0.58345099 cgl7120423 CIRH1A 84916 2.32427 0.020881688 0. 199859371 1.47240415 0.51144615 cgl6984812 PLEKHH2 130271 -2.32335 0.02093219 0. 199920095 0.72290795 0.56746672 cg08993267 BRCA1 672 2.32323 0.020938893 0. 199920095 1.38273422 0.57412263 cg06041363 FU20699 55020 2.32299 0.020951854 0. 199920095 1.36955064 0.58188786 cg08623383 Clorf38 9473 2.32288 0.020957502 0. 199920095 1.35668394 0.58319887 cg08699435 NAT5 51126 2.32259 0.020973551 0. 199920095 1.37995238 0.5864764 cgl6882703 PSMB6 5694 2.32254 0.020976257 0. 199920095 1.39354392 0.57785397 cgl5002204 C6orfl39 55166 2.32231 0.020988873 0. 199920095 1.38323964 0.57760186 cgl6776350 CD84 8832 2.32225 0.020991993 0. 199920095 1.37666225 0.57180315 cg03424436 CEP250 11190 2.32216 0.020996973 0. 199920095 1.39134661 0.56184449 cgl3823136 ST6GALNAC5 81849 2.32206 0.0210025 0. 199920095 1.38237712 0.58466115 cgl7979628 NENF 29937 2.32205 0.021003253 0. 199920095 1.36454131 0.56787011 cg23877385 GCNT3 9245 -2.32165 0.021024798 0. 199920095 0.72299238 0.56706333 cg09256683 CCL14 6358 -2.3216 0.021027922 0. 199920095 0.73541853 0.57997176 cg21746887 FZD1 8321 2.32131 0.021043748 0. 199920095 1.3680745 0.57729931
eg 14757492 DDX49 54555 -2.32129 0.021044849 0.199920095 0.73164507 0.58042558 cg22396691 MRPS25 64432 2.32087 0.021067528 0.200018849 1.36050793 0.57024002 cgl9932177 RFC 3 5983 2.3205 0.021087904 0.200018849 1.36358992 0.5899052 cg08162780 GDF15 9518 2.32038 0.021094725 0.200018849 1.3799268 0.56676079 cgl4104257 SLC36A1 206358 2.32034 0.021097083 0.200018849 1.35620591 0.57835821 cg26751195 SPN 6693 -2.32005 0.021112927 0.200068799 0.72864973 0.56101251 cgl0887021 PCDHB2 56133 2.31962 0.021136419 0.200068799 1.36637688 0.58597217 cg21909391 FU42393 401105 -2.31957 0.021139242 0.200068799 0.72776512 0.55097822 cgl8221862 TMEFF2 23671 2.31941 0.021147982 0.200068799 1.36191949 0.57543364 cg26264314 NALP5 126206 -2.31929 0.021154663 0.200068799 0.73782605 0.58743445 cgl3980719 TNP1 7141 -2.319 0.02117059 0.200120451 0.7303998 0.5813332 cg04915566 RUNX1 861 2.31872 0.021185812 0.200165396 1.38080629 0.58970351 cgl0674793 DVL3 1857 2.31823 0.021212832 0.200321717 1.37564367 0.5787616 cg09325101 OSTbeta 123264 2.31797 0.021227227 0.200358707 1.3795295 0.58087939 cgl7717588 GTDC1 79712 -2.31752 0.021252385 0.200427971 0.72841364 0.55813836 cg26149678 IL18BP 10068 2.31736 0.021261066 0.200427971 1.36740669 0.56948366 cgl l959435 IFNA1 3439 -2.3172 0.021270158 0.200427971 0.72524091 0.57951795 cgl8216249 FU21908 79657 2.31683 0.021290339 0.200427971 1.36680617 0.57260992 cg24812167 SNAPC4 6621 2.31677 0.021293953 0.200427971 1.36756676 0.58168616 cg03835332 ELL3 80237 2.3167 0.021297881 0.200427971 1.36208462 0.57588746 cgl4934821 GPSM1 26086 -2.31652 0.021307932 0.200427971 0.72069468 0.57442517 cgl l063110 CPA5 93979 -2.31622 0.021324275 0.200483084 0.72012072 0.5753328 cg24512973 MUC1 4582 -2.31555 0.021361362 0.200670171 0.72658784 0.56625656 cg25043279 C7orf33 202865 -2.31538 0.02137073 0.200670171 0.73591914 0.57629084 cg26647600 CCR8 1237 -2.31525 0.021378214 0.200670171 0.72583109 0.56799617 cgl7758148 JMY 133746 -2.3149 0.021397738 0.200670171 0.73193193 0.57437475 cg25225238 GRM3 2913 2.31476 0.021405409 0.200670171 1.37378245 0.57664381 cgl9067730 PPGB 5476 2.31473 0.021407137 0.200670171 1.36073869 0.58098023 cg08054038 PVRL2 5819 2.31409 0.02144295 0.200754657 1.37262686 0.56676079 cgl4451276 AOAH 313 2.31369 0.021465271 0.200754657 1.38001552 0.57613957 cg02273078 USP14 9097 2.31336 0.021483234 0.200754657 1.37732737 0.57240823 cg26155617 DDO 8528 -2.31332 0.021485612 0.200754657 0.72186919 0.58652683 cg27606341 FYB 2533 2.31303 0.021501949 0.200754657 1.40072045 0.59378782 cg20423977 PLAC4 191585 -2.3129 0.021509193 0.200754657 0.7286203 0.57523195 cg07339138 CCDC13 152206 -2.31283 0.021513195 0.200754657 0.72283328 0.56318072 cgl5107670 WT1 7490 2.31282 0.021513685 0.200754657 1.42196675 0.56197055 cgl0347418 ZNF436 80818 -2.31271 0.02151958 0.200754657 0.72851332 0.5988806 eg 19669439 BTRC 8945 2.31259 0.021526716 0.200754657 1.39116003 0.57931626 cg09455096 POl 7514 2.3123 0.021542781 0.200754657 1.37592058 0.58425777 cg25589890 ULBP1 80329 -2.31191 0.021564403 0.200754657 0.72433384 0.59343485 cg05732530 DUSP2 1844 2.31169 0.021577004 0.200754657 1.36261933 0.59792255 cgl8107072 CGI-38 51673 2.31135 0.021596185 0.200754657 1.3733851 0.56544978
cgl7073891 PLAC1 10761 -2.31118 0.021605277 0.200754657 0.73429641 0.59315752 cg26443244 GDPD4 220032 -2.31118 0.021605431 0.200754657 0.73437005 0.57366882 cg20141916 PLEK2 26499 2.31112 0.021608968 0.200754657 1.36949206 0.58894716 cg27437944 FXR1 8087 2.31105 0.021612876 0.200754657 1.37968357 0.57740016 cg09238677 C3AR1 719 2.311 0.021615614 0.200754657 1.36706246 0.59938483 cgl7118262 CCL1 6346 2.31079 0.021627511 0.200767646 1.38835868 0.57089552 cg25095951 RPS26 6231 2.31016 0.021662731 0.200893967 1.39068393 0.57825736 cg02519806 SYNP02 171024 2.31002 0.021670541 0.200893967 1.38313815 0.58400565 cgl8655584 SLC22A18 5002 -2.30998 0.021672635 0.200893967 0.71904638 0.56630698 eg 14437986 C6orf25 80739 2.3096 0.021694038 0.200994928 1.36089357 0.58713191 cgl4118546 KIAA1012 22878 2.30908 0.02172343 0.201035192 1.36547768 0.55697862 cg21453309 FAM 101A 144347 -2.30891 0.021733396 0.201035192 0.72675215 0.59056071 cgl0124491 MGC29891 126626 2.30886 0.021735912 0.201035192 1.39919964 0.55783582 cgl7648241 ALKBH8 91801 2.30878 0.021740435 0.201035192 1.39039228 0.5821904 cg06459378 CYP3A7 1551 -2.30856 0.021752652 0.201050944 0.72472265 0.56988705 cgl6107172 SLC27A5 10998 -2.30825 0.021770612 0.201119737 0.72674154 0.55254135 cg07634191 SCARA5 286133 -2.30786 0.021792338 0.201223234 0.73208513 0.58173659 cg02855426 CPA5 93979 2.30758 0.02180796 0.20126028 1.36483489 0.58017346 cgl2172720 SYNPO 11346 -2.30706 0.021837383 0.20126028 0.71394869 0.57180315 cg27050763 AHCTF1 25909 -2.30694 0.021844264 0.20126028 0.72708504 0.58965309 cg21842478 H0XB13 10481 2.30673 0.021856524 0.20126028 1.36886312 0.59056071 cgl7460095 PLEKHC1 10979 2.30666 0.021860219 0.20126028 1.42776771 0.57477814 cgl9091641 ZP2 7783 -2.30662 0.021862551 0.20126028 0.73067086 0.57165188 cgl9896347 DNAH10 196385 -2.30621 0.021885856 0.20126028 0.73235504 0.58491327 cgl3450057 POLN 353497 -2.3061 0.02189191 0.20126028 0.71916291 0.58249294 cg20371650 PRAF2 11230 -2.3056 0.021920526 0.20126028 0.72548402 0.55269262 cg21624282 LOC122258 122258 -2.30542 0.021930466 0.20126028 0.72585689 0.56439088 eg 19485804 NGEF 25791 -2.30521 0.021942853 0.20126028 0.72600262 0.56701291 cg04382920 SLC25A31 83447 -2.30519 0.021943499 0.20126028 0.73243438 0.54563332 cg02320454 GPR150 285601 2.30498 0.021955918 0.20126028 1.36413698 0.58229125 cgl8219951 GABRG2 2566 2.3049 0.021960062 0.20126028 1.39448304 0.58284591 cg21115990 LRP5 4041 -2.30483 0.021964248 0.20126028 0.73056014 0.57422348 cgl2001148 FU33790 283212 2.30482 0.021964743 0.20126028 1.37722012 0.5802743 cg21096915 MGC16291 84856 2.3044 0.021988856 0.201329949 1.35498101 0.56812223 cgl8123596 PIP5K2B 8396 2.30432 0.021993402 0.201329949 1.35864021 0.58511497 cgl2797788 NUTF2 10204 -2.3038 0.02202306 0.201438848 0.72547983 0.59656111 cg08434396 FMR1 2332 -2.30281 0.022079508 0.201438848 0.71155954 0.55395321 cgl5298545 LOC81691 81691 -2.30278 0.022081349 0.201438848 0.7236536 0.57752622 cgl2554573 PARP3 10039 2.30265 0.022088438 0.201438848 1.36422437 0.57356797 cg02580606 KRTHA3B 3884 -2.30261 0.022090791 0.201438848 0.72500779 0.57210569 cg05593325 GALNT12 79695 2.30227 0.022110205 0.201438848 1.37250493 0.57588746 cgl4840416 ZFP36L2 678 -2.30224 0.022112089 0.201438848 0.73604562 0.57850948
cgl4727952 BIRC2 329 2.30193 0.022129863 0.201438848 1.36234068 0.57714804 cg27194614 STK4 6789 2.30184 0.022134931 0.201438848 1.37585748 0.57392094 cg04595021 C21orf86 257103 -2.3018 0.022137232 0.201438848 0.73279267 0.57379488 cg05606799 KISS1 3814 -2.30169 0.022143366 0.201438848 0.72318406 0.57175272 cg06887167 CIT 11113 2.30167 0.022144661 0.201438848 1.38423958 0.58254336 cgl6267266 IL17F 112744 -2.30167 0.022144698 0.201438848 0.72513585 0.57573618 cg07761912 T0R1AIP2 163590 2.30117 0.022173693 0.201438848 1.38531049 0.57835821 cgl5423764 GLYAT 10249 -2.30098 0.022184156 0.201438848 0.72809518 0.56343284 cg09054876 PECI 10455 2.30081 0.022193908 0.201438848 1.35880048 0.58748487 cg04478795 SMO 6608 2.30076 0.022196743 0.201438848 1.36995649 0.57593788 cg07512345 TNP2 7142 -2.30024 0.022226788 0.201438848 0.71981788 0.55213796 cg03080985 SH3BGRL2 83699 2.30005 0.022237851 0.201438848 1.38023429 0.55390278 cg20225275 ATP6V0E 8992 2.29997 0.022242415 0.201438848 1.37300176 0.58249294 cg06282059 UBE2E1 7324 -2.29983 0.0222507 0.201438848 0.72497534 0.55707947 cgl5519208 HISTIHIE 3008 2.2998 0.022252334 0.201438848 1.37949634 0.58314845 cg21577049 WDR69 164781 2.29978 0.022253069 0.201438848 1.375374 0.58824123 cgl5312323 KRTAP4-4 84616 -2.2997 0.022258112 0.201438848 0.7304872 0.57982049 cg03723845 BTNL8 79908 -2.29906 0.022294686 0.201608538 0.71866458 0.57175272 eg 16792632 ESR2 2100 2.2989 0.022304127 0.201608538 1.36035817 0.5899052 cg00714377 SLA2 84174 2.29852 0.022325786 0.201608538 1.3691387 0.57039129 cg23003881 FAM44B 91272 2.29833 0.022337221 0.201608538 1.36885259 0.5744756 cgl5796978 LHCGR 3973 2.2981 0.022350041 0.201608538 1.36728606 0.58355184 cg03277051 COL8A1 1295 2.29809 0.022350837 0.201608538 1.37008386 0.58224082 cgl2647320 POGZ 23126 -2.29806 0.022352494 0.201608538 0.7204094 0.57606394 cgl9210770 ACCN4 55515 2.29791 0.022361204 0.201608538 1.3631687 0.59499798 cgl7207590 APH1B 83464 2.29759 0.022379437 0.201677836 1.35528498 0.58899758 cg20609368 HBD 3045 -2.29719 0.022403096 0.201795948 0.72911735 0.58365268 cg05861567 MLC1 23209 2.29678 0.022426625 0.2018242 1.38493651 0.58461073 cgl8913171 SLAMF9 89886 -2.29677 0.02242734 0.2018242 0.73004875 0.55702904 cgl4916288 CCL23 6368 2.29634 0.022452142 0.201925181 1.38282857 0.57306374 cg24266542 POLR3B 55703 2.29612 0.022464694 0.201925181 1.3611097 0.57034086 cg27342801 REG3A 5068 -2.29603 0.02247024 0.201925181 0.72313341 0.56867689 cg22037919 CCM2 83605 2.29556 0.022497382 0.202047114 1.37361188 0.58387959 cgl4120784 GTF2IRD1 9569 2.29542 0.022505539 0.202047114 1.3779043 0.58287112 cg06438300 FAM 19A2 338811 2.29525 0.022515505 0.202047114 1.3714866 0.5577854 cgl3697378 DIRAS3 9077 2.29466 0.022549752 0.202236566 1.35483393 0.59509883 cg05376895 PNMA3 29944 -2.29452 0.022557768 0.202236566 0.74038456 0.56983663 cgl8329349 CAV1 857 2.29363 0.022609781 0.20255471 1.36029144 0.57029044 cg20951539 PXT1 222659 -2.29355 0.022614439 0.20255471 0.73029812 0.58808996 cg23909633 IL24 11009 -2.29281 0.022657938 0.202808925 0.71917516 0.5802743 cg09406238 MTMR8 55613 2.2927 0.022664032 0.202808925 1.36341655 0.57825736 cg23389061 C14orfl22 51016 2.29231 0.022687179 0.202856775 1.37741813 0.58002219
cg05322019 SEMA4G 57715 -2.29211 0.022698849 0.202856775 0.73494126 0.56106293 cg22224704 GSTP1 2950 2.29207 0.022701204 0.202856775 1.37168003 0.58698064 cg20050012 KIAA0100 9703 2.29187 0.022712738 0.202865044 1.38011242 0.56908027 cgl8964732 TMCOl 54499 2.29115 0.022755022 0.203049123 1.36990497 0.57800524 cg06215939 MAPK8IP3 23162 2.29104 0.022761526 0.203049123 1.36518731 0.59323316 cg06655504 GDPD1 284161 2.29093 0.02276778 0.203049123 1.36198139 0.57911456 cgl5903837 P2RY6 5031 -2.2908 0.02277582 0.203049123 0.73063608 0.5742739 cg08611714 KRTHA2 3882 -2.28996 0.022824921 0.203392044 0.73724122 0.57543364 cg05924191 FU20582 54989 -2.2894 0.022857916 0.203427734 0.72715254 0.58768657 cg20791593 NEU4 129807 -2.28929 0.022864689 0.203427734 0.72787177 0.56877773 cg20091959 L3MBTL 26013 -2.2892 0.022869487 0.203427734 0.73506623 0.55889472 cg23780947 TMEM48 55706 2.28917 0.022871477 0.203427734 1.36916709 0.55995361 cg24409107 GALE 2582 -2.28833 0.022921174 0.203758091 0.73885459 0.56499597 cg02399449 CLDN12 9069 2.28815 0.022931782 0.203758091 1.38474118 0.57734974 cg01507173 IL1F5 26525 -2.28797 0.022942331 0.203758091 0.72527589 0.56676079 cgl3473336 SLC5A2 6524 2.28782 0.02295124 0.203758091 1.36250568 0.56287818 cg08970446 SLC1A7 6512 -2.28752 0.022969178 0.203821657 0.72882496 0.5708451 cgl9666391 UNQ689 401138 -2.28734 0.022979717 0.203821657 0.7391188 0.57820694 cg24003542 MCC 4163 2.28714 0.022991203 0.203828988 1.36708308 0.57508068 cg05986149 BRIP1 83990 2.28647 0.023030942 0.204086684 1.38369228 0.58501412 cg00116234 ADAMTSLl 92949 2.28626 0.023043463 0.204103059 1.38023839 0.59081283 cg04144788 0XCT2 64064 2.28575 0.023073899 0.204188944 1.37500215 0.56439088 eg 14506668 FHL1 2273 -2.28574 0.023074515 0.204188944 0.72770949 0.56222267 cgl8304195 KBTBD8 84541 2.28532 0.023099558 0.204316003 1.37554211 0.5751311 cgl5750705 GJB4 127534 -2.285 0.023118296 0.204387202 0.7335087 0.57765228 cg02288165 SN 6614 -2.28463 0.023140297 0.204487175 0.73405902 0.57402178 cgl2626085 UEV3 55293 2.28386 0.023186465 0.204634622 1.36348366 0.58491327 cg05862431 MGC13125 84811 2.28372 0.023194833 0.204634622 1.36958474 0.59530052 cgl6691888 LRP2 4036 2.28372 0.023194852 0.204634622 1.36118444 0.56106293 cg26687173 LOC126248 126248 2.28328 0.023221408 0.204634622 1.35774221 0.58758572 cg25416363 RBM 15 64783 2.2832 0.023225773 0.204634622 1.37581771 0.58425777 cg25799433 SIRPB1 10326 2.28296 0.023240062 0.204634622 1.37265996 0.5841065 cg23412850 S0CS2 8835 2.2827 0.023255631 0.204634622 1.36742524 0.57694635 cg27339143 PSRC1 84722 2.28269 0.02325627 0.204634622 1.37242201 0.57316458 cg03641225 DIRAS3 9077 2.28249 0.023268578 0.204634622 1.35858842 0.58834207 cgl0661591 TFG 10342 2.28247 0.023269807 0.204634622 1.36828217 0.58617386 cg02657438 ST0N2 85439 -2.28217 0.02328779 0.204634622 0.73483697 0.56837434 cgl5893253 CSTB 1476 2.28209 0.0232922 0.204634622 1.35687978 0.58345099 cg25969673 TBC1D19 55296 2.28191 0.0233033 0.204634622 1.36926978 0.57155103 cgl9905251 SLIT3 6586 2.28167 0.023317265 0.204634622 1.35327907 0.56287818 cgl8103150 Cllorf47 283294 -2.2816 0.023321758 0.204634622 0.72408696 0.56388665 cg21795497 FU23554 79864 2.28092 0.023362685 0.204634622 1.39040372 0.54775111
cg27226618 ACPI 52 -2.2805 0.023388012 0.204634622 0.73423969 0.56560105 cg09686635 Clorfl07 27042 2.28048 0.023389143 0.204634622 1.37060535 0.57896329 cg21487207 HOXC4 3221 2.28035 0.0233967 0.204634622 1.37215812 0.58420734 cg22199118 C8orf34 116328 -2.28017 0.023407734 0.204634622 0.73136063 0.56771884 cg00126698 BTK 695 -2.2799 0.023423969 0.204634622 0.73360768 0.57054256 cg20259534 BUB1B 701 2.27976 0.02343232 0.204634622 1.3648018 0.57145018 cg20311501 APC 324 2.27948 0.023448995 0.204634622 1.37168102 0.57881202 cg l7241013 NEK2 4751 2.27921 0.023465578 0.204634622 1.35525438 0.57639169 cg07654934 LXN 56925 2.27899 0.023478784 0.204634622 1.36621615 0.58849334 cg22432908 KLRC2 3822 -2.27893 0.023482072 0.204634622 0.74169073 0.57619 cg02045085 MPP5 64398 2.27881 0.02348925 0.204634622 1.3528845 0.58511497 cg23828212 MAN1A2 10905 2.27863 0.023500159 0.204634622 1.35922644 0.59056071 cg02210887 GUCY1A3 2982 -2.27855 0.023504978 0.204634622 0.73013413 0.57755143 cg01278696 SMARCA5 8467 2.27823 0.023524288 0.204634622 1.37153666 0.59192215 cg06532493 C10orf70 55847 2.27819 0.023526949 0.204634622 1.37553936 0.58299718 cgl4254419 AMPD2 271 2.27786 0.02354687 0.204634622 1.37346704 0.58844292 eg 14982472 ABCG1 9619 2.2778 0.023550782 0.204634622 1.35587918 0.56739109 cg01465620 ACVR2B 93 2.27772 0.023555217 0.204634622 1.35842027 0.56287818 cg07595943 LOC161931 161931 2.27755 0.023565611 0.204634622 1.37267464 0.60432634 cg08351143 UBE2R2 54926 -2.2773 0.023580946 0.204634622 0.73920548 0.57008875 cg06745740 HGF 3082 2.27715 0.023589677 0.204634622 1.3875357 0.56882816 cgl8915143 PDE6A 5145 -2.27704 0.023596645 0.204634622 0.73706318 0.56615571 cg24890286 HIPK2 28996 -2.27703 0.023597382 0.204634622 0.73275061 0.57624042 cg03727165 C8orf4 56892 -2.27698 0.023600221 0.204634622 0.74351364 0.57613957 cg20022511 G1P2 9636 2.27682 0.023610172 0.204634622 1.36099482 0.58556878 cg21970438 TTLL2 83887 -2.27667 0.023618929 0.204634622 0.73139276 0.59121622 cgl4821083 SEPHS2 22928 2.27655 0.023625997 0.204634622 1.36634148 0.56454215 cg02906939 HNMT 3176 -2.27649 0.02362964 0.204634622 0.7266928 0.56973578 cg27533013 KCNRG 283518 -2.27635 0.023638528 0.204634622 0.72118723 0.58652683 cgl4106085 FOXD2 2306 2.27602 0.023658719 0.204716735 1.36613086 0.5909641 cgl7453778 CASR 846 2.27579 0.023672345 0.20473772 1.34900906 0.55823921 cgl0057065 Clorfl04 284618 2.27562 0.023682557 0.20473772 1.36199132 0.57225696 cg04025590 CCDC21 64793 2.27493 0.02372494 0.204962214 1.36642903 0.55612142 cg00135056 C3orf37 56941 2.27483 0.023730706 0.204962214 1.3554799 0.58128278 cg04653021 DIRC2 84925 2.27418 0.023770597 0.204962214 1.35273723 0.58435861 cgl2274567 SH2D1B 117157 -2.27416 0.023771794 0.204962214 0.73047418 0.57190399 cgl6970232 APC 324 2.27414 0.023773096 0.204962214 1.36520679 0.56971057 cg25335775 MRPS14 63931 2.27399 0.023782205 0.204962214 1.36331949 0.57845906 eg 14260643 CYP3A5 1577 2.27384 0.023790888 0.204962214 1.35772613 0.56287818 cg22152667 OCM 4951 -2.27348 0.02381315 0.204962214 0.72981708 0.58118193 cg20406878 NR5A2 2494 -2.27338 0.023819036 0.204962214 0.73851283 0.58660246 cg24776407 MYEOV 26579 -2.27334 0.023821446 0.204962214 0.73032466 0.54951593
cg00462311 NFATC4 4776 2.27326 0.023826424 0.204962214 1.38711374 0.57382009 cgl5125634 RAB11A 8766 2.27303 0.023840636 0.204992253 1.36594971 0.57810609 cgl4832358 FU10379 55133 2.2728 0.023854907 0.20502278 1.36616125 0.57422348 cg03157806 FAM 11A 84548 -2.27227 0.023887454 0.20515741 0.73258805 0.58375353 cg03146158 MY01E 4643 2.27211 0.023896984 0.20515741 1.36479617 0.58052642 cg24620905 MTMR11 10903 2.27198 0.023904898 0.20515741 1.35484651 0.58970351 cgl0125119 CSDE1 7812 2.2717 0.023922153 0.20515741 1.38104829 0.57745059 cg07414384 BAZ1A 11177 2.27149 0.023935219 0.20515741 1.37073678 0.57734974 cg22187630 CACNAIA 773 2.27129 0.023947526 0.20515741 1.36593027 0.60669625 cg25936385 FAIM2 23017 -2.27127 0.023948361 0.20515741 0.72783211 0.57134933 eg 10896886 ACTR3B 57180 2.27113 0.023956929 0.20515741 1.35298574 0.57588746 cg23570261 FU10006 55677 2.27073 0.023981798 0.20515741 1.35657793 0.56514724 cg01508386 SCYLIBPI 92344 2.27064 0.023987343 0.20515741 1.37533297 0.59172045 cg09551916 CFHR2 3080 -2.27062 0.023988584 0.20515741 0.72796609 0.5961073 cg24719575 REST 5978 2.26997 0.0240283 0.205405212 1.35997953 0.57079468 cg02002676 APOBEC3B 9582 2.26928 0.024070952 0.205623336 1.35869336 0.58506454 cg01103730 IL20 50604 -2.26921 0.024075321 0.205623336 0.73186927 0.5881908 cgl6508857 WWOX 51741 2.2687 0.024106685 0.205799292 1.36524597 0.54921339 cg01405107 HOXB5 3215 2.26791 0.024155773 0.20612634 1.36591989 0.5665591 cgl5905124 MGC13034 134288 -2.26726 0.02419555 0.206271915 0.7246222 0.59424163 cg07126559 SGCG 6445 -2.26684 0.024221556 0.206271915 0.7262578 0.59797297 cg00903242 CHL1 10752 2.26679 0.024225036 0.206271915 1.37358049 0.56388665 cgl8139900 ZNF140 7699 2.26665 0.024233397 0.206271915 1.36059896 0.56857604 cg07841014 REG IB 5968 -2.26637 0.024250859 0.206271915 0.72577365 0.55339855 cgl0150530 LRMP 4033 2.26636 0.024251375 0.206271915 1.3690895 0.57523195 cgl l231018 LIPF 8513 -2.26625 0.024258326 0.206271915 0.73269029 0.57039129 cg27625732 TBC1D13 54662 2.26613 0.024265953 0.206271915 1.34734773 0.56519766 cgl7329249 MAT2B 27430 2.26577 0.024288244 0.206271915 1.37192979 0.57250908 cgl2343638 PCDHB12 56124 2.26574 0.024290166 0.206271915 1.35979346 0.57437475 cgl4833385 HLA-DMA 3108 2.26572 0.024291486 0.206271915 1.37090254 0.58657725 cg06432655 CLIPR-59 25999 2.26541 0.024310553 0.206278553 1.36361986 0.5866781 cg25169784 UGCGL2 55757 2.26504 0.024333783 0.206278553 1.36566743 0.57871117 cg08096038 C6orflll 25957 -2.26486 0.024345033 0.206278553 0.72544149 0.56668516 cgl9252175 FU20035 55601 2.26484 0.024345736 0.206278553 1.38486158 0.57921541 cgl9056418 TMC8 147138 2.26463 0.024358824 0.206278553 1.37334832 0.56706333 cg03163246 PPBPL2 10895 -2.26459 0.024361715 0.206278553 0.73318711 0.57548407 cgl2067287 MYOM 1 8736 -2.26449 0.024367777 0.206278553 0.73358757 0.58743445 cg02005755 SLC13A4 26266 -2.26373 0.024414899 0.206355043 0.73389457 0.57608915 cg08274234 SEMA3E 9723 2.26361 0.024422487 0.206355043 1.37695336 0.59444332 cg23423382 ZNF287 57336 2.26327 0.024443658 0.206355043 1.35352472 0.56434046 cg03427831 MTHFR 4524 2.26313 0.024452583 0.206355043 1.34419586 0.56403792 cg06918467 OLIG3 167826 2.26307 0.024456304 0.206355043 1.35582584 0.57588746
cg23350274 RDH12 145226 -2.26266 0.02448189 0.206355043 0.7300081 0.57008875 cgl3625113 ZNF482 10773 2.26266 0.024482277 0.206355043 1.37119834 0.57714804 cg22968727 RPL11 6135 2.26259 0.024486181 0.206355043 1.36155788 0.59540137 cg24274600 RHOBTB3 22836 2.26249 0.02449263 0.206355043 1.35166048 0.56792053 cg22367989 NRP2 8828 2.26249 0.024492668 0.206355043 1.364004 0.57750101 cg06434428 HAPLN1 1404 -2.26245 0.024495513 0.206355043 0.7346835 0.57694635 cgl9530885 SCGB3A2 117156 -2.26176 0.024538454 0.206414566 0.72722152 0.57528237 cgl5104484 PEX26 55670 2.26168 0.024543581 0.206414566 1.35584445 0.59172045 cg03575468 PDHA1 5160 -2.26157 0.024550131 0.206414566 0.72361303 0.60044373 cgl0057218 GSDML 55876 -2.26128 0.024568669 0.206414566 0.73511652 0.56116378 cg25734864 PROZ 8858 -2.26123 0.024571787 0.206414566 0.74072293 0.57583703 cg23219570 FGF23 8074 2.2611 0.02458007 0.206414566 1.35501227 0.59116579 cgl0957584 FAM86A 196483 2.26062 0.02460986 0.206414566 1.3698125 0.57018959 cg26066361 CLEC7A 64581 -2.26058 0.024612549 0.206414566 0.74213026 0.56524808 cg08687825 PRSS35 167681 2.26047 0.024619275 0.206414566 1.36002883 0.58763614 cgl7051321 BNC1 646 2.25988 0.024656616 0.206414566 1.36535706 0.58123235 cgl3640200 AMIG02 347902 2.25977 0.024663517 0.206414566 1.35382778 0.5594998 cgl3218435 PET112L 5188 2.25975 0.024664814 0.206414566 1.37164858 0.5697862 cg02664205 PDE7B 27115 -2.2596 0.02467394 0.206414566 0.73645957 0.58319887 cgl7939444 C8orf4 56892 -2.25951 0.024680036 0.206414566 0.73199438 0.57467729 eg 18099844 C15orf24 56851 -2.25947 0.024682481 0.206414566 0.73389897 0.55334812 cg07654843 MY018B 84700 -2.25947 0.024682678 0.206414566 0.72320234 0.56212182 cg00811081 FU21908 79657 2.25909 0.024706466 0.206414566 1.363026 0.57709762 cg09201327 TNC 3371 2.25898 0.024713584 0.206414566 1.3661205 0.57740016 cg03849074 ZNF306 80317 2.25885 0.024721618 0.206414566 1.38153795 0.5881908 cg27345286 FBX03 26273 2.25877 0.024726736 0.206414566 1.35824243 0.5873336 cgl0364182 LOC119710 119710 2.25837 0.024751664 0.206414566 1.36539871 0.57003832 cgl9228118 CSMD2 114784 2.25812 0.024767569 0.206414566 1.37227001 0.58153489 cgl8152311 FAM49B 51571 2.25792 0.02478013 0.206414566 1.37001926 0.56106293 cgl3131015 GUCY2C 2984 -2.25782 0.024786659 0.206414566 0.73671885 0.57034086 cg02091100 GUCA1A 2978 -2.25781 0.024787106 0.206414566 0.73766193 0.56358411 cg07461318 NTN4 59277 2.25762 0.024799007 0.206414566 1.35958393 0.55647439 cgl4272706 ALS2CR12 130540 -2.25746 0.024809213 0.206414566 0.72386583 0.57795482 cgl4981132 HNRPA1 3178 2.25742 0.024812171 0.206414566 1.36714436 0.57452602 cg26692016 APOBEC1 339 -2.25736 0.024815607 0.206414566 0.73105593 0.57417305 cgl2348970 SLC24A2 25769 -2.25693 0.024843031 0.206552827 0.72320311 0.58541751 cg21828898 UBE1 DC1 79876 2.25646 0.02487249 0.206558942 1.36397876 0.57387051 cg03038672 CLDN9 9080 -2.25618 0.024890244 0.206558942 0.72966087 0.57165188 cg24820809 MB 4151 -2.25616 0.024891883 0.206558942 0.72477194 0.58269464 cg23180270 RNF113A 7737 -2.25614 0.024892909 0.206558942 0.73181646 0.56681121 cgl9130550 OLFML2B 25903 2.25607 0.024897774 0.206558942 1.38239405 0.56423961 cg27367554 CGI-09 51605 2.25552 0.024932509 0.206757407 1.35482126 0.55344897
cgl l964613 ARSE 415 -2.25504 0.024962729 0.206790853 0.73367073 0.57412263 cgl0636246 AIM2 9447 2.2548 0.024977913 0. 206790853 1 .36588794 0.57825736 cgl7169613 RALB 5899 2.25471 0.024983946 0. 206790853 1 .35028702 0.58345099 cg05779068 OR2W1 26692 -2.25457 0.024992975 0. 206790853 0 .72626202 0.56681121 eg 14640682 GYS1 2997 2.25446 0.025000067 0. 206790853 1 .35717228 0.57266035 cg20648108 CTTNBP2NL 55917 2.25429 0.025010855 0. 206790853 1 .36887237 0.57992134 cg25013838 MY018B 84700 -2.25427 0.025012238 0. 206790853 0 .72666671 0.5744756 cg24999727 HSD17B13 345275 -2.2538 0.02504193 0. 206946859 0, .73442582 0.56794574 cg06564900 FIGN 55137 2.2533 0.025074 0. 207082041 1 .38673112 0.58577047 cg25088874 BMPR1B 658 2.25321 0.025079946 0. 207082041 1 .34483586 0.58158532 cg04752565 LOC57228 57228 2.25268 0.025113622 0. 207238418 1 .36503603 0.5866781 cg27590397 SSTR1 6751 2.25254 0.025122329 0. 207238418 1 .34656929 0.57588746 cg01035422 PLIN 5346 -2.2524 0.025131396 0. 207238418 0 .72684015 0.58024909 cg09705062 SLC22A11 55867 -2.25192 0.02516236 0. 207399193 0, .72943042 0.5742739 cgl5760943 ETV5 2119 2.25163 0.025180563 0. 207399193 1 .36040275 0.59403994 cgl8043455 SEC61A1 29927 2.25151 0.025188269 0. 207399193 1 .36599159 0.58788826 cg24389347 C3orf22 152065 -2.2514 0.025195608 0. 207399193 0, .73281677 0.58249294 eg 14588638 RHBDD3 25807 2.25125 0.025205121 0. 207399193 1 .37023546 0.58814038 cg07980518 RNF152 220441 2.25098 0.025222625 0. 207427105 1 .36978012 0.59983865 cg22193702 PADI1 29943 -2.25057 0.025248555 0. 207427105 0, .73267258 0.57669423 cg20772904 SHCBP1 79801 2.25053 0.025251265 0. 207427105 1.3652685 0.57750101 cg00436282 STATH 6779 -2.25052 0.025251901 0. 207427105 0, .72113144 0.57311416 cg04209631 Cllorf54 28970 2.24966 0.025307453 0. 207794165 1 .34881638 0.56509681 cgl5485859 Clorfll6 79098 -2.24923 0.025335113 0.207932 0, .72868738 0.57820694 cgl7945001 IGSF21 84966 2.24888 0.025357449 0. 208026035 1 .34574704 0.58551835 cg08411049 SERPINB5 5268 -2.24839 0.025389432 0. 208199094 0, .74223465 0.55223881 cg21361470 C6orfll7 112609 2.24812 0.025406483 0. 208220455 1 .34455589 0.57162666 cg21130374 MX2 4600 2.24801 0.025413814 0. 208220455 1 .38083319 0.57215611 cg00347904 SCUBE3 222663 2.24752 0.025445677 0. 208240647 1 .37351844 0.56439088 cg02553486 CORIN 10699 2.24746 0.025449098 0. 208240647 1 .34714655 0.58365268 cg03167883 FU46365 401459 -2.24725 0.025463301 0. 208240647 0, .73355963 0.55531464 cg02303361 AP2S1 1175 2.24699 0.025479856 0. 208240647 1 .35651069 0.57492941 cg08570521 TLL1 7092 2.24698 0.02548064 0. 208240647 1 .35445566 0.57573618 cg22189725 ADC 113451 2.24687 0.025487892 0. 208240647 1 .36519032 0.55647439 cgl9282782 IL27RA 9466 -2.24678 0.025493147 0. 208240647 0, .73860657 0.56658431 cg06710648 DAB1 1600 2.24663 0.025503395 0. 208240647 1 .34803763 0.57281162 cg07141002 H1F0 3005 2.24639 0.025518933 0. 208278587 1 .34046332 0.59444332 cg21145624 MEIS3 56917 2.24612 0.025536595 0. 208283777 1 .35094766 0.57805567 cgl0895543 CDKN2A 1029 2.24601 0.025543713 0. 208283777 1 .34422918 0.57371924 cg22391400 SLK 9748 2.24574 0.025561215 0. 208283777 1 .35417979 0.57669423 cg23092072 AFF1 4299 2.24571 0.025563136 0. 208283777 1 .35501695 0.56030658 cg02964385 STK38 11329 2.24549 0.025577008 0. 208308046 1 .34880686 0.58067769
cgl3553455 COL17A1 1308 -2.24511 0.025602099 0.208393663 0.73443046 0.5717023 0 0 0 0 0 eg 18598959 PIK4CB 5298 -2.24466 0.025630998 0. 208393663 0.73060558 0.56792053 0 0 0 0 0 cg04882759 MYOCD 93649 -2.2446 0.025635008 0. 208393663 0.7338855 0.56181928 0 0 0 0 0 cg04391540 ZNF541 84215 2.24443 0.025646406 0. 208393663 1.35250847 0.56701291 0 0 0 0 0 cg23414387 CYP4B1 1580 -2.24433 0.025652841 0. 208393663 0.73343429 0.56650867 0 0 0 0 0 cgl8502522 SCAMP2 10066 2.24433 0.025652906 0. 208393663 1.34303653 0.57230738 0 0 0 0 0 cg08413366 PPP3CB 5532 2.24379 0.025687706 0. 208587757 1.36050136 0.58158532 0 0 0 0 0 cg27553955 KCNG3 170850 2.24352 0.0257057 0. 208608783 1.34834781 0.57049213 0 0 0 0 1 cgl0358212 ASCIZ 23300 -2.24337 0.025715472 0. 208608783 0.73417295 0.58355184 0 0 0 0 0 cg06101225 STIL 6491 2.24324 0.025723599 0. 208608783 1.35693854 0.58703106 0 0 0 0 0 eg 18429742 ZDHHCl l 79844 -2.24309 0.025733931 0. 208608783 0.73145 0.5864764 0 0 0 0 0 cgl7452277 EBAG9 9166 2.24287 0.025748136 0. 208635495 1.3688025 0.56736587 0 0 0 0 0 cg01500421 HARSL 23438 2.24231 0.025784897 0. 208819955 1.36059013 0.56897943 0 0 0 0 0 cg03138405 GLT25D1 79709 2.2421 0.02579808 0. 208819955 1.35161034 0.58687979 0 0 0 0 0 cg03400060 BHMT2 23743 2.24154 0.025835019 0. 208819955 1.34629396 0.57049213 0 0 0 0 0 cg05421688 Clorf76 148753 2.24119 0.025858172 0. 208819955 1.35530764 0.58466115 1 0 0 0 0 cg26428825 KCNV2 169522 -2.24117 0.025859508 0. 208819955 0.73716541 0.56908027 0 0 0 0 0 cg01302245 P53AIP1 63970 -2.24102 0.025869289 0. 208819955 0.73303558 0.5691307 0 0 0 0 0 cgl3401681 GRPR 2925 2.24095 0.025873621 0. 208819955 1.35920131 0.57326543 0 0 0 0 1 cg27305895 C9orf76 80010 2.24067 0.025892441 0. 208819955 1.3636914 0.57422348 0 0 0 0 0 cg05186188 AQP8 343 -2.2405 0.025903515 0. 208819955 0.73302366 0.5639875 0 0 0 0 0 cg27063607 MRPL33 9553 2.24036 0.025912351 0. 208819955 1.35062577 0.56499597 0 0 0 0 0 eg 10935550 BTG2 7832 -2.2401 0.025929426 0. 208819955 0.73844431 0.5873336 1 0 0 0 0 cg08292050 SOCS4 122809 -2.2401 0.025929809 0. 208819955 0.73329022 0.57755143 0 0 0 0 0 cg27121132 DERL1 79139 2.24009 0.025930544 0. 208819955 1.37631433 0.5586426 0 0 0 0 0 cg02705666 GTF2B 2959 2.24006 0.025932546 0. 208819955 1.3766453 0.56928197 0 0 0 0 0 cg26450541 ZNF187 7741 2.24002 0.025934699 0. 208819955 1.36326188 0.57371924 0 0 0 0 0 cg26716323 TOMM7 54543 2.23938 0.025976864 0. 209063258 1.36038642 0.580476 0 0 0 0 0 cg08113203 SMR3B 10879 -2.23923 0.025986781 0. 209063258 0.73324365 0.58435861 0 0 0 0 0 cgl0333959 MGMT 4255 -2.23878 0.026016293 0. 209212662 0.73195849 0.56988705 0 0 0 0 0 cg04691375 LRRC42 115353 2.23859 0.026029348 0. 209229664 1.36026848 0.57432432 0 0 0 0 0 cg24547948 ADPRHL2 54936 -2.23824 0.026052477 0. 209301534 0.73531681 0.55682735 0 0 0 0 0 cg26550234 SLC39A12 221074 -2.23788 0.026075859 0. 209301534 0.73145707 0.57351755 0 0 0 0 0 cgl5765532 Cllorf30 56946 2.23777 0.026083314 0. 209301534 1.36062217 0.56693727 0 0 0 0 1 cg05633152 SLC10A1 6554 -2.23772 0.02608658 0. 209301534 0.73708417 0.56983663 0 0 0 0 1 cg25065147 MCFD2 90411 2.23738 0.026109411 0. 209301534 1.35557721 0.57321501 0 0 0 0 0 cg20399252 EBPL 84650 -2.2371 0.026127731 0. 209301534 0.72055346 0.59933441 0 1 0 0 0 cg23877831 MRPL51 51258 2.23695 0.026137491 0. 209301534 1.34944141 0.56736587 0 0 0 0 0 cg23769143 TIMP4 7079 2.23683 0.026145214 0. 209301534 1.354939 0.59731747 0 0 0 1 1 cgl0379112 LOC57146 57146 2.23661 0.026159808 0. 209301534 1.36026531 0.58884631 0 0 0 0 0 cg05417950 SPAT A 5 166378 2.23644 0.026171663 0. 209301534 1.37239687 0.58531666 0 0 0 0 0 cg23623692 ATP 1 OA 57194 -2.23629 0.026181609 0. 209301534 0.73337769 0.57301331 0 0 0 0 0
cgl4246617 MITF 4286 2.23628 0.026181725 0.209301534 1.35365607 0.5751311 0 0 1 0 1 cgl0426652 WDR75 84128 2.23627 0.026182592 0. 209301534 1.37639701 0.57508068 0 0 0 0 0 cg23824713 SERPINB5 5268 -2.23614 0.02619152 0. 209301534 0.73470297 0.57977007 0 0 0 0 0 cg09645888 ME3 10873 2.2351 0.026260425 0. 209552789 1.34417126 0.59570391 0 0 0 0 0 cg04544498 MAGEE1 57692 2.23507 0.026262689 0. 209552789 1.34276014 0.58461073 0 0 0 0 0 cg22309489 OKL38 29948 -2.235 0.026267022 0. 209552789 0.73185146 0.564643 0 0 0 0 0 cgl3243219 MDS1 4197 2.23457 0.026295525 0. 209552789 1.3664981 0.56192013 1 0 0 0 0 cg02322989 LRP1B 53353 2.23448 0.026301571 0. 209552789 1.35871759 0.59726704 0 0 0 0 1 cg02600394 TXK 7294 -2.23425 0.026317182 0. 209552789 0.73492886 0.58264421 0 0 0 0 0 cg20477318 TIMM23 10431 2.23413 0.026324668 0. 209552789 1.37807425 0.56423961 0 0 0 1 0 cg09296044 CCNDBP1 23582 2.23411 0.026326249 0. 209552789 1.3548724 0.58158532 0 0 0 0 0 cg27420123 FSHB 2488 -2.23407 0.026329284 0. 209552789 0.72898523 0.57271077 0 0 0 0 0 cgl5812071 NXF5 55998 -2.23402 0.026332544 0. 209552789 0.73596835 0.59328358 0 0 0 0 0 cg06340713 CHM 1121 -2.23319 0.026387532 0. 209903032 0.73909317 0.57392094 0 0 0 0 0 cgl2029639 MAB21L1 4081 2.23292 0.026405555 0. 209908068 1.34677828 0.56726503 1 0 1 0 1 cg25302370 C6orfl65 154313 2.23285 0.026410119 0. 209908068 1.35609802 0.57805567 0 0 0 0 0 cg25635500 RRP22 10633 2.23268 0.026421827 0. 209913877 1.3497627 0.57442517 1 0 0 0 0 cg00231644 TUBB2A 7280 2.23237 0.026442221 0. 209956596 1.35854688 0.57200484 0 0 0 0 0 cgl2259537 ZNF606 80095 2.23167 0.026489451 0. 209956596 1.36254536 0.57205526 0 0 0 0 0 cgl4173613 TMEM33 55161 2.23162 0.026492901 0. 209956596 1.34747873 0.58471158 0 0 0 0 0 cgl2530080 PMCHL1 5369 -2.23147 0.026502564 0. 209956596 0.73718176 0.60311618 0 0 0 0 0 cg06250108 LOC92691 92691 2.23132 0.026512856 0. 209956596 1.34769596 0.5507261 0 0 0 0 0 eg 18630040 PLA2G7 7941 2.23127 0.026516203 0. 209956596 1.36327721 0.57160145 1 0 0 0 0 eg 16898420 PRG-3 54886 -2.2311 0.026527508 0. 209956596 0.73778257 0.56227309 1 0 0 0 0 cg02126424 CTRL 1506 -2.23104 0.026531322 0. 209956596 0.73426189 0.55687777 0 0 0 0 0 cg23655719 CCL19 6363 -2.23057 0.026563036 0. 209956596 0.72435983 0.56469343 0 0 0 0 0 cg21091679 ELL2 22936 2.23044 0.026571904 0. 209956596 1.34301525 0.58511497 0 1 1 1 0 cgl8621299 EVL 51466 2.23038 0.026576024 0. 209956596 1.36906601 0.57603873 0 0 0 0 0 cg09147222 CPNE4 131034 2.23026 0.026583776 0. 209956596 1.37719591 0.57709762 0 0 0 0 1 cg21574752 COPG2 26958 2.2302 0.026587832 0. 209956596 1.37425568 0.58743445 0 0 0 0 1 cgl9591881 CD34 947 2.23016 0.026590497 0. 209956596 1.35488791 0.59131706 1 0 0 0 1 cgl l944101 CD40LG 959 -2.23014 0.026591893 0. 209956596 0.7368079 0.59066156 0 0 0 0 0 cg21166999 ROS1 6098 -2.22979 0.02661565 0. 210029114 0.7397225 0.58324929 0 0 0 0 0 cg04907664 EFNB1 1947 -2.22968 0.026623044 0. 210029114 0.73375019 0.55042356 1 0 0 0 0 eg 14366490 TXNL6 115861 -2.22915 0.026658402 0. 210201904 0.74188643 0.5584409 0 0 0 0 0 eg 19464944 FCGR1A 2209 2.22894 0.026673185 0. 210201904 1.38406676 0.56665994 0 0 0 0 0 cgl2216205 C6orflll 25957 -2.22877 0.026684465 0. 210201904 0.74037478 0.57195442 0 0 0 1 0 cg25560840 KIAA0427 9811 2.2287 0.026689177 0. 210201904 1.364818 0.56832392 0 0 0 0 0 cg03131527 BDH 622 -2.2282 0.026722542 0. 210201904 0.74050964 0.56887858 0 0 0 0 0 cg22226839 ATP2B4 493 2.22818 0.026724045 0. 210201904 1.36151364 0.57235781 0 0 0 0 1 cg08647727 MGC50559 254013 2.22817 0.026724907 0. 210201904 1.35761919 0.5663574 0 0 0 0 0 cg21750602 PPP2R2D 55844 -2.22805 0.026732884 0. 210201904 0.73330703 0.57039129 0 0 0 0 0
eg 14847483 TMEM85 51234 2.22785 0.026746154 0.210219811 1.34981711 0.59061113 cg25921910 CDC73 79577 2.22646 0.026840238 0.210872615 1.3615506 0.56212182 cg26679231 C6orfl52 167691 2.2262 0.026858292 0.210927805 1.35257824 0.56060912 cgl9831369 HPS4 89781 -2.22585 0.026881632 0.210967604 0.73035529 0.57165188 cgl5976539 C18orfl6 147429 -2.2258 0.026885424 0.210967604 0.73925046 0.58158532 cg09739907 NAPE-PLD 222236 2.22511 0.026932445 0.211249886 1.35665117 0.59681323 cg22927134 CHRM5 1133 -2.22492 0.026944777 0.211259959 0.7390369 0.56759278 cgl4414534 TM0D1 7111 -2.22422 0.026992845 0.211550104 0.72957594 0.56847519 cg24326142 CSF1 1435 2.22334 0.027052602 0.211931574 1.36028602 0.58935055 eg 16534499 ZNF223 7766 2.22207 0.027139608 0.212526121 1.3626504 0.57271077 cg00324733 NUCB2 4925 2.22189 0.027151651 0.212533395 1.34981165 0.58193828 cg27600794 PNLIPRP1 5407 -2.2209 0.027220003 0.212803939 0.72964675 0.58022388 cg27446185 VTC 1 79679 -2.22086 0.027222198 0.212803939 0.73957132 0.56630698 cgl9782075 LOC144233 144233 2.22066 0.027236227 0.212803939 1.35341279 0.57886245 cg01476044 MGAM 8972 -2.22044 0.027251408 0.212803939 0.73557416 0.58274506 cgl8282619 ZNF706 51123 2.22024 0.02726504 0.212803939 1.35109356 0.58360226 cg20833786 MRGPRX3 117195 2.22022 0.027266578 0.212803939 1.36032538 0.55652481 cgl2865837 SIM1 6492 2.22022 0.027266712 0.212803939 1.37298815 0.56348326 cg01623187 FAM 112A 149699 2.21968 0.027303715 0.212803939 1.34519009 0.58148447
TNFSF12- cg00031162 TNFSF13 407977 -2.21958 0.027310332 0.212803939 0.74173583 0.57392094 cg25299176 YWHAE 7531 2.21936 0.027325857 0.212803939 1.35306578 0.58138362 cgl4501253 FU36980 286032 2.21927 0.027331966 0.212803939 1.34716265 0.57755143 cgl9432434 SIKE 80143 2.21926 0.027332451 0.212803939 1.35311514 0.5794171 cgl3877895 GKN1 56287 -2.21915 0.027339739 0.212803939 0.73271472 0.58153489 cg04739485 MLXIP 22877 -2.21897 0.027352105 0.212803939 0.73574399 0.57064341 cgl6125615 CAPS 828 -2.21896 0.027353137 0.212803939 0.72704621 0.57528237 cgl4178895 C6orfl05 84830 2.21848 0.027385861 0.212913998 1.35456877 0.57215611 cg02555579 SLC25A18 83733 -2.21835 0.027395261 0.212913998 0.74012571 0.56151674 cg25153340 PLEKHK1 219790 2.21824 0.027402932 0.212913998 1.3581552 0.60472973 cg25093045 FU46481 389197 -2.21811 0.027411819 0.212913998 0.74609995 0.58380395 cgl3405161 EIF2C2 27161 2.2178 0.02743294 0.212939704 1.35274897 0.55370109 cgl5384599 SETMAR 6419 2.21759 0.027447328 0.212939704 1.33967251 0.56338241 cg01808090 NUBP1 4682 2.21758 0.027448535 0.212939704 1.35938046 0.58062727 cg05822100 CDH6 1004 2.21696 0.02749099 0.213018533 1.35627368 0.59222469 cg22492966 JMJD1C 221037 2.21695 0.027491905 0.213018533 1.37316568 0.57971965 cgl9215261 SLC25A2 83884 -2.21669 0.027509643 0.213018533 0.73408862 0.57013917 cg22385764 ASB8 140461 2.21664 0.027513616 0.213018533 1.36726411 0.57553449 cgl6179125 CTSZ 1522 2.21663 0.027514393 0.213018533 1.35020705 0.55707947 cgl2127282 HOXD4 3233 2.21599 0.027558089 0.213233813 1.34953524 0.58985478 cg02659232 PUS3 83480 2.21538 0.027601044 0.213233813 1.35967531 0.57462687 cgl2994003 LBR 3930 2.21514 0.027617678 0.213233813 1.36687521 0.5532977
cg26747293 FU39155 133584 2.21496 0.027630005 0.213233813 1.34337763 0.57356797 cgl l554507 NEUR0D6 63974 -2.21484 0.027638429 0.213233813 0.73734954 0.57674466 cgl5211677 WBP5 51186 2.21442 0.027667689 0.213233813 1.34772748 0.5759883 cg20172280 0LFML2B 25903 2.21415 0.027686371 0.213233813 1.34828945 0.58173659 cgl l943820 KIAA1754 85450 -2.21401 0.027696257 0.213233813 0.73287737 0.55450787 cgl8424091 HSPA1L 3305 2.21383 0.027708325 0.213233813 1.35449198 0.55410448 cgl3559495 ALG14 199857 2.21378 0.027712228 0.213233813 1.34643876 0.5881908 cg20857455 CPNE8 144402 2.21353 0.027729262 0.213233813 1.36414188 0.60351956 cg03223878 BHLHB2 8553 2.21325 0.027748785 0.213233813 1.36099474 0.58758572 cg04691961 C3orf57 165679 -2.21323 0.027750498 0.213233813 0.74287197 0.57316458 cg25490410 TUBGCP5 114791 2.21296 0.02776903 0.213233813 1.34110657 0.56882816 cgl8075299 C14orf54 161142 -2.21296 0.027769474 0.213233813 0.7370043 0.57583703 cgl6112157 KRT6C 140446 -2.2129 0.027773692 0.213233813 0.73272505 0.5751311 cgl9211800 MARCKS 4082 2.21269 0.027788228 0.213233813 1.34841906 0.580476 cg21331821 ZSCAN1 284312 2.21261 0.027793476 0.213233813 1.34392518 0.55173457 cg26216632 C2orf27 29798 -2.21257 0.027796715 0.213233813 0.73828372 0.5357503 cg05839235 NPR3 4883 2.21233 0.027813546 0.213233813 1.35187866 0.57165188 cg02812142 ACMSD 130013 -2.21231 0.027814765 0.213233813 0.73838777 0.57452602 cg02813121 S100A12 6283 -2.21229 0.027815796 0.213233813 0.7308139 0.5794171 cgl8508525 CD36 948 -2.21227 0.027817213 0.213233813 0.73182198 0.56923155 cgl l398517 FAM 112A 149699 -2.21203 0.027834566 0.213233813 0.74850018 0.57750101 cg22837289 MDS028 55846 2.21184 0.027847706 0.213233813 1.3526817 0.57593788 cgl2432709 CCDC68 80323 -2.2118 0.027850636 0.213233813 0.72922986 0.56706333 cg07207937 MRPL1 65008 2.2115 0.027871279 0.213233813 1.36802761 0.57397136 cg07056057 DYNLL2 140735 -2.2115 0.027871416 0.213233813 0.74143077 0.57180315 cg00920960 BIRC4 331 2.21138 0.027879473 0.213233813 1.3590783 0.57472771 cgl0726357 TSCOT 57864 2.21127 0.027887478 0.213233813 1.340987 0.57392094 cg22663080 GCLM 2730 2.21102 0.027904684 0.213233813 1.34826512 0.58125756 cgl8997662 ZNF441 126068 2.21095 0.027910072 0.213233813 1.34171177 0.56222267 cg05112986 SUPT3H 8464 2.21095 0.027910172 0.213233813 1.34848018 0.57422348 cg08737421 MAX 4149 2.21068 0.027928665 0.21327549 1.34146678 0.57331585 cg05807991 TRAM1L1 133022 2.21055 0.027937933 0.21327549 1.35015122 0.55561718 cgl0281002 TBX5 6910 2.20994 0.027980521 0.213435037 1.36911701 0.57921541 cg05093686 MAB21L1 4081 2.20993 0.027981547 0.213435037 1.35282583 0.57089552 cg24435704 PARP12 64761 -2.20958 0.028006002 0.213435037 0.72804112 0.55874345 cg21365602 GBP4 115361 2.20956 0.028007847 0.213435037 1.36818862 0.57387051 cgl5258980 ARHGAP25 9938 2.20946 0.028014639 0.213435037 1.36315512 0.57064341 cg26245202 ELK4 2005 -2.2089 0.028054255 0.213613326 0.73074724 0.56822307 cgl2970724 CRLF1 9244 -2.20868 0.028069191 0.213613326 0.74400985 0.56686164 cg20168375 LOC90624 90624 2.20837 0.028091468 0.213613326 1.36467423 0.57619 cg21255732 GPD1L 23171 -2.20786 0.028127013 0.213613326 0.73124761 0.58844292 cg00730260 FU32894 144360 -2.20786 0.028127349 0.213613326 0.7365857 0.55546591
cgl7693270 DGAT2L6 347516 2.20786 0.028127484 0.213613326 1.36288883 0.57321501 cg08647446 RASSF6 166824 2.20774 0.028135727 0.213613326 1.35621534 0.58289633 cg08847038 C10orf63 219670 2.20772 0.028136989 0.213613326 1.36312453 0.58516539 cgl0590292 BIN2 51411 2.2077 0.028138576 0.213613326 1.34599584 0.57326543 cg09772827 PRCP 5547 2.20726 0.028169401 0.213739839 1.34726509 0.55859217 cg06500476 FU11017 55286 -2.20709 0.028181645 0.213739839 0.72491091 0.56519766 cg02077793 CARM1 10498 2.20651 0.028222409 0.213739839 1.36738359 0.589048 cgl6205058 OSGEP 55644 2.20631 0.028236905 0.213739839 1.36710701 0.57089552 cg26232005 SMOX 54498 2.20624 0.028242104 0.213739839 1.35135501 0.58345099 cgl9412675 SNX24 28966 2.20619 0.0282453 0.213739839 1.34575696 0.57094595 cg20767356 HORMADl 84072 -2.20606 0.02825464 0.213739839 0.72835812 0.56267648 eg 14889768 RAB32 10981 -2.20602 0.028257689 0.213739839 0.73564904 0.58829165
DKFZp434N0
cg26832154 35 84222 -2.20571 0.028279528 0.213739839 0.74080587 0.58577047 cg06000781 BST1 683 -2.20561 0.028286398 0.213739839 0.73918603 0.57155103 cg20587336 ARMC1 55156 2.20543 0.028299203 0.213739839 1.35552793 0.58042558 cgl9403346 MGC45800 90768 2.20542 0.02829985 0.213739839 1.35911525 0.58103066 cgl5001381 AXIN1 8312 2.20541 0.028300544 0.213739839 1.35166525 0.59898144 cg l3221588 TTF2 8458 2.20488 0.028338366 0.213940997 1.36983211 0.57992134 cg01371258 ZNF184 7738 2.20465 0.028354793 0.213980539 1.34177512 0.57230738 cgl l337780 ZNF439 90594 -2.20409 0.028394451 0.214195287 0.74744136 0.58738403 eg 14826683 SPRR2D 6703 -2.20372 0.028420914 0.214310376 0.73589591 0.564643 cg00622677 TSPAN5 10098 2.20354 0.028433726 0.21432247 1.35332215 0.56847519 cg22778145 CLK4 57396 2.20305 0.028468838 0.214374517 1.33543959 0.58198871 cgl0318258 RIPK3 11035 -2.203 0.028472309 0.214374517 0.73921677 0.56393707 cg01095482 TIE1 7075 -2.20289 0.02848003 0.214374517 0.73555171 0.57336628 cg20613889 FSHR 2492 -2.20275 0.028490053 0.214374517 0.74269678 0.56887858 cgl8680021 OTUB2 78990 2.20238 0.028516505 0.214374517 1.34561058 0.58693021 cgl2638745 C21orfl3 150082 2.20234 0.028518993 0.214374517 1.35710583 0.57843384 eg 18497960 RBM 12 10137 2.20234 0.028519103 0.214374517 1.34384634 0.57563534 cgl7269548 PPIA 5478 -2.20197 0.028545494 0.214419501 0.73415346 0.56887858 cg00840403 CHST4 10164 2.20195 0.028547513 0.214419501 1.35918572 0.57487898 cg20979602 PAPD4 167153 2.20153 0.028577105 0.214557496 1.35946064 0.58178701 cg25375711 TRMT12 55039 2.20126 0.028596221 0.214616755 1.36076564 0.56993748 cg20022122 GCKR 2646 -2.20089 0.028622753 0.214731607 0.72555425 0.5830476 cg02588309 OSRF 23548 2.20047 0.028653051 0.214810682 1.34019409 0.56408834 cg00884221 IGFBP7 3490 2.20015 0.028675949 0.214810682 1.34528758 0.5821904 cg08469834 CASP4 837 2.20004 0.028684084 0.214810682 1.35296664 0.57871117 cgl9658284 FU45645 375287 2.20001 0.028686428 0.214810682 1.35149999 0.56983663 eg 11334469 GTF2I 2969 2.19996 0.028689459 0.214810682 1.36799383 0.58738403 cg21596317 PAM 5066 2.1997 0.028708259 0.21486731 1.34015887 0.58834207 cg00405568 NMT1 4836 2.19932 0.028735966 0.214970656 1.35805549 0.56887858
cg04228573 MAP2K6 5608 2.1992 0.02874455 0.214970656 1.35721847 0.57371924 0 0 0 0 1 cg07221454 MS4A10 341116 -2.19899 0.028759765 0. 215000362 0.72835255 0.58350141 0 0 0 0 0 cg21906716 TP73 7161 -2.1987 0.028780575 0. 215071859 0.73069688 0.56771884 1 0 0 0 0 cgl8317951 PLEKHF2 79666 2.19799 0.028831829 0. 215191565 1.3558134 0.58158532 0 0 0 0 0 cgl5583058 SDCCAG3 10807 2.19796 0.028833428 0. 215191565 1.33720811 0.58783784 0 0 0 0 1 cg01846065 STAM2 10254 2.19785 0.02884155 0. 215191565 1.34869067 0.57674466 0 0 0 0 0 eg 11494656 ARR3 407 -2.19785 0.028841607 0. 215191565 0.72971365 0.56887858 0 0 0 0 0 cgl7214107 FGF2 2247 2.19768 0.028853919 0. 215199466 1.34282088 0.57538322 0 0 0 1 0 cgl3619915 SLITRK3 22865 2.19736 0.028876877 0. 215286728 1.35651123 0.56519766 1 0 0 0 1 cg02046532 DEFB129 140881 -2.19682 0.028916055 0. 215468169 0.73913967 0.57286204 0 0 0 0 0 cg25411725 SLC22A13 9390 -2.19653 0.028936844 0. 215468169 0.74106403 0.56918112 0 0 0 0 0 cg04070847 CD200R1 131450 2.19636 0.028949365 0. 215468169 1.34831838 0.57523195 0 0 0 0 0 cg25211252 KCNMB3 27094 2.19635 0.028950354 0. 215468169 1.34046901 0.58703106 0 1 0 0 0 cg06240124 PLK1 5347 2.19622 0.02895968 0. 215468169 1.34602654 0.59136749 0 0 0 0 0 cg01459955 AHRR 57491 -2.19601 0.028974481 0. 215468169 0.73270998 0.58380395 0 1 0 0 0 cg04969878 TMEM19 55266 -2.19576 0.028993037 0. 215468169 0.74052818 0.57775313 0 0 0 0 0 cg05959392 C10orf32 119032 2.19546 0.029014838 0. 215468169 1.36018685 0.59308189 0 0 0 0 0 cg26776069 Clotfl76 64789 2.1954 0.029019162 0. 215468169 1.36151671 0.56882816 0 0 0 0 0 cg25346576 CCDC55 84081 2.19539 0.029019684 0. 215468169 1.34995005 0.58098023 0 0 0 0 0 cgl7814481 FBP1 2203 2.1952 0.02903354 0. 215468169 1.36214877 0.58370311 1 0 0 0 0 eg 11204562 C10orf81 79949 -2.19505 0.029044383 0. 215468169 0.72934831 0.57649254 0 0 0 0 0 cg04755662 AR 367 -2.195 0.029047692 0. 215468169 0.74033192 0.57003832 0 0 0 0 0 cg20120491 DMC1 11144 2.19472 0.029068495 0.2155081 1.34125803 0.59270371 0 0 0 0 0 eg 10564498 AXL 558 2.19462 0.029075615 0.2155081 1.36083696 0.56282775 0 0 0 0 1 eg 10986043 TCAP 8557 2.19393 0.029125809 0. 215677492 1.35232419 0.5899052 0 0 0 0 0 cg23055159 COMMD8 54951 2.19378 0.029136574 0. 215677492 1.34587094 0.59479629 0 1 0 0 0 cgl8114671 NOL4 8715 2.19374 0.029139726 0. 215677492 1.36763449 0.58662767 1 0 1 0 1 cgl4433673 UCP2 7351 -2.19368 0.029143582 0. 215677492 0.74262033 0.56307987 0 0 0 0 0 cg06353345 OR51B4 79339 -2.19318 0.029180491 0. 215827513 0.73204547 0.59318274 0 0 0 0 0 cg02786378 SLC7A2 6542 -2.19271 0.029214259 0. 215827513 0.73907965 0.57220654 0 0 0 0 0 cgl9791253 ATP2B4 493 2.19268 0.029217023 0. 215827513 1.36086763 0.56817265 0 0 0 0 1 cg04774694 DPEP2 64174 -2.19265 0.029218775 0. 215827513 0.74754606 0.55450787 0 0 0 0 0 cg25770411 WBSCR23 80112 -2.19263 0.029220285 0. 215827513 0.73633926 0.556071 0 0 0 0 0 cg23941599 FEM 1C 56929 2.19182 0.029279382 0. 216123659 1.35792415 0.56731545 0 0 0 1 0 cgl5516226 BTNL9 153579 -2.19141 0.029309822 0. 216123659 0.73446206 0.57205526 0 0 0 0 0 cg00746130 BAT5 7920 2.19134 0.029314536 0. 216123659 1.37073559 0.57654296 0 0 0 0 0 cg22067472 CYB5-M 80777 2.19133 0.029315444 0. 216123659 1.36021091 0.56514724 0 0 0 1 0 cg22593486 OR10H1 26539 -2.19123 0.029322887 0. 216123659 0.73832364 0.57896329 0 0 0 0 0 cgl4679587 GLS2 27165 2.19116 0.029328191 0. 216123659 1.35813044 0.58506454 0 0 0 0 0 cg09735905 HHLA3 11147 2.19086 0.029350172 0. 216136129 1.33193844 0.56307987 1 0 0 0 0 cg07409200 FU40919 144809 2.19073 0.02935906 0. 216136129 1.36182662 0.58524103 0 0 0 0 0 cgl l721194 SLAMF7 57823 -2.1904 0.029383177 0. 216136129 0.7361097 0.57462687 0 0 0 0 0
cgl0035922 Clorfl02 127700 2.19025 0.02939437 0.216136129 1.3472648 0.55067568 cg22511262 WT1 7490 2.19018 0.029399997 0.216136129 1.35285658 0.5926785 cg04127303 ZZZ3 26009 2.19012 0.029404329 0.216136129 1.34632029 0.57845906 cg23306832 KIAA0999 23387 2.18971 0.029434479 0.216136129 1.35225995 0.56933239 cgl7095936 TBX19 9095 -2.18965 0.029438893 0.216136129 0.72938602 0.57997176 cg26082838 FLRT3 23767 2.18945 0.029453209 0.216136129 1.35894404 0.57477814 cgl0063179 MTNR1A 4543 2.18935 0.029460851 0.216136129 1.34572821 0.5550121 cg25539131 VHL 7428 -2.18929 0.029465222 0.216136129 0.74773934 0.5569282 cg23749046 GPR61 83873 -2.18923 0.029469204 0.216136129 0.74301411 0.56257564 cgl2445208 ZNF583 147949 -2.18913 0.029476815 0.216136129 0.74494326 0.56862646 cgl9471399 CCDC77 84318 -2.18842 0.029529034 0.216436032 0.73519248 0.5665591 cgl9355919 MRO 83876 2.18806 0.029555283 0.216476827 1.35310913 0.57119806 cg08104838 SDHA 6389 -2.18801 0.029559465 0.216476827 0.73968229 0.57351755 cgl8702197 HOXD3 3232 2.18779 0.029575222 0.216476827 1.34111656 0.57286204 cg02860543 IGF2BP3 10643 2.18773 0.029579881 0.216476827 1.37485075 0.58541751 cg24120841 THRB 7068 2.18704 0.029630406 0.216666317 1.34381381 0.54840662 cgl9703628 PSMB4 5692 2.18688 0.029642336 0.216666317 1.33766618 0.56575232 cg24747396 BAP1 8314 2.18678 0.029649637 0.216666317 1.35136197 0.58309802 cg09955730 TMED5 50999 2.18644 0.029675296 0.216666317 1.35334678 0.56126462 cg24980583 SSBP1 6742 2.18643 0.029675849 0.216666317 1.35353055 0.57906414 cg01558777 C10orf99 387695 -2.1864 0.02967797 0.216666317 0.74222297 0.58269464 cg23619829 MTFR1 9650 2.18631 0.029685085 0.216666317 1.35573754 0.57785397 cg00630164 KCNQ4 9132 2.18599 0.029708486 0.216753319 1.36470362 0.56756757 cg03550508 SNRPD3 6634 -2.18584 0.029719674 0.216753319 0.75007377 0.58445946 cg21829265 ZNF451 26036 2.18554 0.029741456 0.216756638 1.34889442 0.57850948 cgl5880738 CD3G 917 -2.18553 0.029742799 0.216756638 0.73805666 0.57719847 cg01840268 BTN3A1 11119 2.18525 0.029763018 0.216821359 1.35347943 0.56988705 cg26248486 C12orf58 79738 2.18489 0.029790171 0.216936526 1.34347053 0.57780355 cg24473385 ZNHIT3 9326 2.1847 0.029804169 0.216955838 1.34774912 0.5665591 cg01717706 SOCS1 8651 2.18392 0.029861598 0.217264683 1.34212041 0.580476 cgl7676096 LEOl 123169 2.18371 0.029877794 0.217264683 1.34389722 0.58778741 cg24794992 OTOA 146183 -2.18353 0.029890682 0.217264683 0.74105059 0.58108108 cgl9815589 LOC220070 220070 -2.18352 0.029892042 0.217264683 0.74006589 0.57326543 eg 11384427 TNFRSF7 939 -2.18267 0.029954806 0.217371113 0.74165739 0.56948366 cg26282384 PCDHGB4 8641 2.1826 0.029960504 0.217371113 1.35046003 0.57356797 cg00209951 DENND2C 163259 2.18255 0.029963786 0.217371113 1.34931861 0.58045079 cg27188703 FAIM2 23017 2.1823 0.029982679 0.217371113 1.3364085 0.57296289 cg22077101 MRPL22 29093 2.18218 0.029991409 0.217371113 1.35572807 0.58935055 cgl7051440 CLDN2 9075 2.18199 0.03000553 0.217371113 1.33629991 0.58471158 cg27337148 CAMK1G 57172 2.18191 0.030011643 0.217371113 1.36627013 0.57760186 cg05936800 TNFSF18 8995 -2.18175 0.030023386 0.217371113 0.74661338 0.57036608 cg05102817 RBM 18 92400 -2.18166 0.030030397 0.217371113 0.73785254 0.56857604
cgl3615963 CCR6 1235 2.18158 0.030036489 0.217371113 1.35014014 0.58319887 cg02007463 ITGA7 3679 2.18147 0.030044573 0.217371113 1.34889341 0.57871117 cgl9332710 RIMS4 140730 2.18137 0.030052078 0.217371113 1.34394494 0.58163574 cg04762346 EDG5 9294 2.18109 0.030072714 0.217371113 1.33974755 0.5821904 cg02477931 Cllorf39 399980 -2.18105 0.030076308 0.217371113 0.74265794 0.57094595 cg00435408 RSPRY1 89970 2.18103 0.030077191 0.217371113 1.36362514 0.56857604 cg02441647 COL8A1 1295 2.18018 0.030141138 0.217643076 1.36229954 0.58143405 cg25758314 ARD1A 8260 2.18008 0.030148637 0.217643076 1.33705669 0.58299718 cg01293143 TCEA2 6919 2.17978 0.030171467 0.217643076 1.32768029 0.57165188 cg24243265 MLZE 56169 -2.17967 0.030179038 0.217643076 0.74119077 0.57563534 cgl9644162 TXNL4A 10907 2.17944 0.030196319 0.217643076 1.33736807 0.55723074 cg01049530 BMP3 651 2.17944 0.030196329 0.217643076 1.36586029 0.57563534 cg08704509 GRAMD3 65983 2.17937 0.030202016 0.217643076 1.35621308 0.56671037 eg 19756068 CYP2B6 1555 -2.17932 0.030205872 0.217643076 0.73850994 0.58178701 cg27558666 KLB 152831 -2.17901 0.03022925 0.217729485 0.74181391 0.58045079 cgl5625636 GPR65 8477 -2.17854 0.030264156 0.217885279 0.74470182 0.55894514 cg26154999 FU22746 79843 2.17804 0.030301974 0.217885279 1.35127331 0.59252723 cg21484964 C15orf24 56851 -2.17781 0.030319309 0.217885279 0.73765323 0.57049213 eg 19740969 CXCL9 4283 -2.17752 0.030341024 0.217885279 0.73896239 0.56887858 cg00010193 FU35816 401114 -2.17751 0.030341641 0.217885279 0.73838036 0.54891085 cg21700166 GPR68 8111 2.1775 0.030342898 0.217885279 1.34141838 0.59938483 cg05881762 UBE3A 7337 2.17744 0.030346874 0.217885279 1.34524336 0.57477814 cg01601573 GAB1 2549 2.17726 0.030360905 0.217885279 1.34215579 0.55516337 cg04633384 C18orfl 753 2.17709 0.030373666 0.217885279 1.35025553 0.58294675 cg24238205 FAM 111A 63901 2.17692 0.03038616 0.217885279 1.35024112 0.57508068 cgl4379865 GRM5 2915 -2.17683 0.030392817 0.217885279 0.74128352 0.56766842 cgl7987660 C8orf37 157657 2.17658 0.030412378 0.217885279 1.33911609 0.58854377 cg05022306 HOXC8 3224 2.17621 0.030440121 0.217885279 1.34658482 0.58763614 cg09591663 C6orf66 29078 2.1762 0.030440513 0.217885279 1.35971096 0.5734167 cgl0071275 MYTl 4661 -2.17604 0.030452546 0.217885279 0.73502772 0.56499597 cg20858478 B4GALINT2 124872 2.17599 0.0304569 0.217885279 1.35069321 0.56287818 cg05655041 ASB11 140456 -2.17588 0.030464908 0.217885279 0.73877926 0.56751714 cgl3062935 MRGPRX2 117194 2.17586 0.030466644 0.217885279 1.37164235 0.58314845 cg25725843 ST6GAL2 84620 2.17585 0.030467365 0.217885279 1.34296255 0.56676079 eg 18695429 CSTF2 1478 -2.17567 0.030481085 0.217901908 0.74308355 0.56766842 cgl3323474 TTC18 118491 2.17543 0.030498971 0.217948298 1.35691948 0.58057685 cgl4135551 DAAM2 23500 2.17518 0.030518004 0.218002842 1.34949319 0.59651069 cgl3060646 ADFP 123 2.17467 0.030556923 0.218105627 1.35543856 0.56776926 cg21240812 TSNARE1 203062 2.17458 0.030563194 0.218105627 1.34594937 0.54800323 cgl l221508 CCT6B 10693 2.17437 0.030579141 0.218105627 1.34918688 0.55944938 cg04339860 WWP2 11060 2.17396 0.030610714 0.218105627 1.34799915 0.57997176 cgl7135325 NMD3 51068 2.17384 0.030619715 0.218105627 1.36857219 0.58975393
cg06186973 YWHAG 7532 2.17376 0.030625292 0.218105627 1.34014079 0.56096208 cgl l385473 IMMP1L 196294 2.1737 0.030630536 0.218105627 1.35694492 0.56076039 cgl5098690 ZNF330 27309 2 .17368 0.030631381 0.218105627 1.34309447 0.56287818 cg08557686 RTN4R 65078 -2 .17352 0.030644084 0.218105627 0.73886003 0.57044171 cgl l594137 EDG3 1903 2 .17346 0.030648084 0.218105627 1.34451509 0.60261194 cg07526675 PCSK1N 27344 -2 .17334 0.030657853 0.218105627 0.74160407 0.56645825 cg08928646 UBE1L2 55236 2 .17278 0.030700396 0.218183295 1.34400821 0.57563534 cg22920417 FU44881 400661 2 .17276 0.030701626 0.218183295 1.35540687 0.5657019 cg21790626 ZNF154 7710 2 .17274 0.030702999 0.218183295 1.36148554 0.5682735 cg23045073 NPHS2 7827 2 .17235 0.030732904 0.218314686 1.34572836 0.56857604 cgl7989037 PRR11 55771 2 .17147 0.030800313 0.218603058 1.34794677 0.57780355 cg09983885 TRIM21 6737 2 .17132 0.030811888 0.218603058 1.3472881 0.55077652 cg05649009 CHRNA1 1134 -2 .17127 0.030815614 0.218603058 0.7364094 0.56242437 cg24242519 FAM49A 81553 2 .17122 0.030819225 0.218603058 1.34420263 0.56000403 cg24453664 CD59 966 2 .17044 0.030878913 0.218945216 1.34479675 0.56141589 cg21667943 CIP29 84324 2 .17005 0.03090874 0.219075475 1.34258733 0.56761799 cg22544376 DGUOK 1716 2 .16979 0.030928707 0.219091269 1.33962357 0.56176886 cg09991975 JOSD1 9929 -2 .16972 0.030933919 0.219091269 0.74912325 0.57029044 cg03954587 UBB 7314 2 .16943 0.030956539 0.219091269 1.36922741 0.589048 cg20088913 FU46363 400002 -2 .16942 0.030956797 0.219091269 0.7386855 0.57717326 cgl3828839 FXYD6 53826 2 .16869 0.031013101 0.219408549 1.34630825 0.57901372 cg03154513 ID1 3397 2 .16841 0.031034541 0.219479037 1.34912638 0.56272691 cg22064129 SLC14A2 8170 -2 .16825 0.03104697 0.219485762 0.74416152 0.57059298 cg02309273 INPP5B 3633 2 .16785 0.031077449 0.219620044 1.35427931 0.57008875 cg24974599 CFH 3075 -2 .16728 0.031121196 0.219772281 0.74141227 0.57220654 cg03109316 ZNF80 7634 -2 .16721 0.031127104 0.219772281 0.73752268 0.57850948 cg21021629 NRIP1 8204 2.1669 0.031150487 0.219772281 0.74481316 0.57997176 cg03630088 CPXM2 119587 2 .16665 0.031169832 0.219772281 1.34675543 0.57346712 cg23080667 STK35 140901 2 .16659 0.031174691 0.219772281 1.33288267 0.57124849 cgl7983274 PPME1 51400 2 .16644 0.031186285 0.219772281 1.34270489 0.55813836 cgl4726637 CR1 1378 2 .16639 0.031189856 0.219772281 1.3534798 0.5663574 eg 19506903 YIPF3 25844 2 .16638 0.031190932 0.219772281 1.32906803 0.57886245 cg04310824 SCP2 6342 2 .16594 0.031225107 0.219932043 1.33021189 0.56474385 cg25257360 CXorf23 256643 -2 .16562 0.03124938 0.220007572 0.74464582 0.57326543 cg06142324 FU25530 220296 -2 .16534 0.03127157 0.220007572 0.74273149 0.56847519 cg03591594 VLDLR 7436 2 .16532 0.031272558 0.220007572 1.33706162 0.58052642 cg20910746 BBOX1 8424 2.1652 0.03128185 0.220007572 0.74929956 0.58556878 cg21331335 KCNV2 169522 -2 .16494 0.031302457 0.220068945 0.7456118 0.55304558 cg02951021 DNCL1 8655 -2 .16479 0.031313593 0.220068945 0.74665914 0.57397136 cg23188547 CDC6 990 2 .16421 0.031359127 0.220247767 1.33768604 0.5759883 cg20229788 GCKR 2646 2 .16385 0.031386831 0.220247767 1.3458637 0.56872731 cg02150910 GZMH 2999 -2 .16382 0.031388768 0.220247767 0.7417446 0.57407221
cg27068170 HSD17B12 51144 2.16378 0.031391901 0.220247767 1.34273893 0.57523195 cg l4707431 C9orf97 158427 2.16372 0.031396625 0.220247767 1.34257303 0.56716418 cg04557868 REL 5966 2.16338 0.031423271 0.220290606 1.34331509 0.57139976 cg06331674 KIAA0241 23080 2.16335 0.031425771 0.220290606 1.3407131 0.56590359 cg l2264551 LOC283377 283377 2.16291 0.031459948 0.22044937 1.33597522 0.57492941 cg04618607 SQLE 6713 2.16219 0.031515654 0.220758829 1.33388091 0.59035902 cg21242004 VTI1A 143187 -2.16186 0.031541898 0.22086176 0.74208792 0.57051735 cg08818984 NR3C1 2908 2.16164 0.031558922 0.220900079 1.35543068 0.57316458 cg00810473 SNX22 79856 2.16138 0.031578716 0.220933356 1.34450033 0.57392094 cg l3821008 WASPIP 7456 2.161 0.031608846 0.220933356 1.373977 0.5680718 cg23472215 GSTM3 2947 2.16093 0.031613803 0.220933356 1.34500617 0.55995361 cg l4694011 CYP19A1 1588 -2.16088 0.031617649 0.220933356 0.74354439 0.57472771 cg00101227 MPZ 4359 -2.1607 0.031632073 0.220933356 0.74913036 0.55975192 cg l0432859 UGT1A7 54577 -2.16069 0.031632996 0.220933356 0.74201974 0.58312324 cg l6814399 HIBCH 26275 2.16053 0.031645043 0.220936803 1.34736326 0.57286204 cg l3301014 SPINT2 10653 2.16023 0.031668641 0.221014104 1.33116002 0.56887858 cg06041240 NXT2 55916 -2.1601 0.03167923 0.221014104 0.74470972 0.58183743 cg l9257550 CA9 768 -2.15953 0.031723594 0.221171758 0.74615646 0.57195442 eg 19524009 NEK3 4752 -2.15951 0.031724959 0.221171758 0.74372014 0.57881202 cg23621817 CH RNA9 55584 -2.15911 0.031756566 0.221287697 0.74223702 0.57780355 cg06213598 ABCA9 10350 -2.15901 0.031764734 0.221287697 0.73947904 0.56958451 cg l4990333 ZNF221 7638 2.15852 0.031802924 0.221473067 1.35341557 0.5691307 cg09509863 CUL3 8452 2.15818 0.031829758 0.221579249 1.34253295 0.58269464 cg00315936 SND1 27044 2.15779 0.031859947 0.221693968 1.34441633 0.58264421 cg23610820 PSG9 5678 2.15745 0.031886987 0.221693968 1.33804951 0.58355184 cg06339657 PDE8B 8622 2.15731 0.031897529 0.221693968 1.32654605 0.54633925 cg22799321 TFPI2 7980 2.15721 0.031906094 0.221693968 1.34860019 0.5751311 cg l4853515 LSM5 23658 2.15717 0.031909323 0.221693968 1.33500591 0.58309802 cg l l251877 C6orf54 26236 -2.15691 0.031929415 0.221693968 0.75256583 0.56439088 cg l3946500 PPAN 56342 -2.15689 0.031930677 0.221693968 0.74874355 0.55869302 cg l3678049 PARC 23113 2.15679 0.031938983 0.221693968 1.33933516 0.56519766 cg l9110684 HAVCR2 84868 2.15569 0.032025843 0.222216222 1.34382522 0.57366882 eg 14834436 M AT1 4331 2.15548 0.032042128 0.222248575 1.34741143 0.57603873 cg l3846796 LSM 14A 26065 -2.15504 0.032077387 0.222303017 0.74513801 0.58718233 cg08524221 ET 79157 2.15493 0.032085356 0.222303017 1.33420019 0.57134933 cg l6796951 C20orfl52 140894 -2.15485 0.032092318 0.222303017 0.74651346 0.55465914 cg22685251 MAP3K4 4216 2.15479 0.032096477 0.222303017 1.34801875 0.55632311 cg l6433922 SFRP4 6424 2.15459 0.032112751 0.22233521 1.3469252 0.60362041 cg08039281 PSMA6 5687 2.15425 0.03213963 0.222363391 1.33742855 0.57079468 cg09087966 CCNG2 901 2.15424 0.032140445 0.222363391 1.33217932 0.56832392 cg l0832166 PWCR1 63968 -2.15401 0.03215896 0.222363391 0.7406944 0.55697862 eg 10997248 FXYD2 486 -2.15395 0.032163431 0.222363391 0.75243563 0.57069383
cg26542130 PCBP1 5093 2.1538 0.032174962 0.222363391 1.33473274 0.5498689 0 0 0 1 0 cg03167339 MICAL-L2 79778 -2.15335 0.032211045 0. 222480274 0.74949539 0.58965309 0 0 0 0 0 cg26898336 TEKT3 64518 2.15311 0.032230233 0. 222480274 1.36657588 0.57777834 0 0 0 0 0 cgl2611860 PIK3C2A 5286 -2.1531 0.032230402 0. 222480274 0.74315604 0.5629286 0 0 0 0 0 cg22127491 NDUFC1 4717 2.1526 0.032270871 0. 222480274 1.34001543 0.57437475 0 0 0 0 0 cgl2343082 CA5A 763 -2.15258 0.03227211 0. 222480274 0.74905934 0.59686366 0 0 0 0 0
DKFZp434N0
cg25807810 62 151313 2.15234 0.032290987 0. 222480274 1.33934352 0.58491327 0 0 0 0 0 cg03368758 LDB2 9079 -2.1521 0.032309998 0. 222480274 0.74934423 0.5725595 0 0 0 0 1 cgl l283860 SLC45A1 50651 2.15193 0.032323964 0. 222480274 1.33564552 0.58743445 0 0 0 0 0 cg25149927 SSH1 54434 2.15178 0.032335553 0. 222480274 1.33398984 0.56973578 0 0 0 0 0 cgl8750756 MGC29671 201305 2.15168 0.032343425 0. 222480274 1.32850707 0.56040742 0 0 0 0 0 eg 11147886 NFAT5 10725 2.15159 0.032350597 0. 222480274 1.33712513 0.56900464 0 0 0 1 1 cgl7029168 NKX2-2 4821 2.15155 0.032354078 0. 222480274 1.33901408 0.61476402 1 0 1 0 1 cg01166674 ABCB8 11194 2.15151 0.032357126 0. 222480274 1.34122798 0.57906414 0 0 0 0 0 cg27159719 TMEM71 137835 2.15122 0.032380367 0. 222480274 1.35883799 0.58178701 0 0 0 0 0 cg00134787 MYH 1 4619 -2.15108 0.032391892 0. 222480274 0.74095361 0.55955022 0 0 0 0 1 eg 14964658 PEX19 5824 2.15105 0.032393609 0. 222480274 1.34334303 0.57523195 0 0 0 0 0 cg03573747 ADIPOQ 9370 -2.15102 0.032395929 0. 222480274 0.73632293 0.57301331 0 0 0 0 0 cg26267561 OXT 5020 2.15094 0.032402578 0. 222480274 1.34783309 0.57548407 0 0 0 0 0 cgl3022129 PHYHD1 254295 -2.15073 0.032419336 0. 222480274 0.73614591 0.56454215 0 0 0 0 0 cg01909921 GFI1B 8328 2.15067 0.032424559 0. 222480274 1.34057687 0.57649254 0 0 0 0 0 cg07579404 RAET1L 154064 2.15044 0.032442357 0. 222522554 1.33428022 0.58531666 0 0 0 0 0 cg08747889 PTK7 5754 2.14967 0.032504255 0. 222813928 1.34904711 0.57472771 0 0 0 0 0 cg02381948 MGMT 4255 -2.14948 0.03251922 0. 222813928 0.73554482 0.57203005 0 0 0 0 0 cg04048259 EDN3 1908 -2.1494 0.032525708 0. 222813928 0.73927043 0.56368495 1 0 0 0 0 cg01733783 HSPA5 3309 -2.14911 0.032548595 0. 222813928 0.74613784 0.57230738 0 0 0 1 0 cgl7074212 ZNF215 7762 2.14907 0.032552444 0. 222813928 1.34822381 0.56908027 0 1 0 0 0 cg05705583 CAMLG 819 2.14896 0.032560861 0. 222813928 1.33758602 0.55753328 0 0 0 0 0 eg 13396068 DCD 117159 -2.14886 0.032569141 0. 222813928 0.72987277 0.55642396 0 0 0 0 0 cg23743472 Cllorf38 399967 -2.14871 0.032581321 0. 222813928 0.74452549 0.56605486 0 0 0 0 0 cgl2975220 MEIS1 4211 2.1484 0.032605567 0. 222813928 1.34557845 0.59025817 1 0 0 0 1 cgl0787197 C6otfl05 84830 2.14819 0.032622325 0. 222813928 1.3334701 0.57926583 0 0 0 0 0 cgl2696750 DNALI1 7802 2.14812 0.032628219 0. 222813928 1.34526909 0.57296289 0 0 0 0 0 cgl0065825 CDH11 1009 2.1481 0.032630095 0. 222813928 1.32947353 0.5770472 1 0 0 0 1 cg21256656 KLK6 5653 2.14801 0.032637462 0. 222813928 1.34562212 0.60195643 0 0 0 0 0 cg27610561 SLC2A10 81031 -2.14788 0.032647961 0. 222813928 0.73028425 0.5841065 0 0 0 0 1 cgl2969407 NCOA7 135112 2.14755 0.032674051 0. 222912433 1.35171067 0.57397136 0 1 0 0 0 cg05395995 LOC221143 221143 2.14679 0.032735175 0. 223249787 1.34047818 0.57366882 0 0 0 0 0 cg03986968 AVEN 57099 -2.14624 0.032779162 0. 223463803 0.74983996 0.57825736 0 0 0 0 0 cgl9555986 MAP7 9053 -2.14576 0.03281862 0. 223463803 0.7520093 0.56847519 0 0 0 0 0 eg 16564824 SNAP25 6616 2.14562 0.032829586 0. 223463803 1.34567571 0.58703106 0 0 0 0 0
cg23759214 MRE11A 4361 2.14562 0.032829906 0.223463803 1.33151313 0.58052642 cg05647859 LIN7A 8825 2.14551 0.032838288 0.223463803 1.35304295 0.56383622 cg01447498 TSNAX 7257 2.14542 0.032845845 0.223463803 1.34743242 0.56968536 cg05788526 MTMR2 8898 2.14539 0.032848355 0.223463803 1.35162315 0.57523195 cgl3044277 NRG4 145957 2.14515 0.032867104 0.22346704 1.35103548 0.58032473 cgl5740366 IMPDH1 3614 2.14509 0.032872203 0.22346704 1.3666256 0.54991932 cg25979644 ATP8B1 5205 -2.14455 0.032916014 0.223685356 0.74444194 0.58193828 cg03918304 HOXD10 3236 2.14407 0.032955008 0.223820953 1.33429543 0.55259177 cg20083871 ACAD9 28976 2.14401 0.032959377 0.223820953 1.33416872 0.57331585 cg08623787 RXRG 6258 2.14365 0.032988983 0.223942477 1.3389918 0.55995361 cgl6620731 ZNF583 147949 2.14344 0.033006188 0.223979767 1.3502866 0.57467729 cgl6962970 RASAL2 9462 2.14325 0.033021288 0.22400274 1.35580361 0.57069383 cg09022808 GAL3ST1 9514 -2.1429 0.033049605 0.224070901 0.74814342 0.57271077 cgl l386709 EPB41L2 2037 -2.14284 0.03305477 0.224070901 0.73903053 0.57150061 cg04532229 SLC9A2 6549 2.14193 0.033128259 0.224155104 1.3466405 0.56101251 cg04457794 CTSE 1510 -2.14161 0.033154472 0.224155104 0.75225194 0.56126462 cgl7792192 CAMSAPl 157922 -2.14158 0.03315669 0.224155104 0.74613811 0.56902985 cg00431549 MGP 4256 2.14149 0.033164211 0.224155104 1.33365038 0.56726503 cg20573420 FU38451 126375 -2.14148 0.033164647 0.224155104 0.7431586 0.57467729 cgl9965810 KCNH7 90134 2.14147 0.033165961 0.224155104 1.33602182 0.56494554 cgl5890111 ABAT 18 2.14146 0.033166854 0.224155104 1.34523935 0.57664381 cg05263682 RNGTT 8732 2.1414 0.033171598 0.224155104 1.34451173 0.56676079 cg24995381 GPR141 353345 -2.14139 0.033172688 0.224155104 0.74797967 0.59792255 cg20793071 TMEM59 9528 2.14042 0.033251029 0.224605103 1.34480341 0.58370311 cg21379008 ATP8B2 57198 2.13995 0.033290098 0.224677244 1.34316951 0.56439088 cg21561173 C21orf81 114035 -2.13989 0.033294459 0.224677244 0.74817957 0.58128278 cg09871043 PKHD1 5314 -2.13986 0.033296956 0.224677244 0.73685774 0.56323114 cg05270634 RND2 8153 2.13955 0.033322567 0.224770747 1.32918231 0.55808794 cg06617418 RGAG1 57529 -2.13907 0.033361365 0.224941938 0.75317752 0.5717023 cg07561400 ZC3HAV1 56829 2.13895 0.033371472 0.224941938 1.33114667 0.55944938 cg23303074 LRAT 9227 2.13868 0.033393538 0.224991712 1.33569609 0.5672146 eg 16575408 MMP1 4312 -2.13833 0.033422353 0.224991712 0.74741623 0.5751311 cg26484333 TMEM34 55751 2.13831 0.033424281 0.224991712 1.34688516 0.58002219 cg26781886 EMB 133418 2.13821 0.03343174 0.224991712 1.34329522 0.55445744 cgl5815843 MFAP5 8076 -2.13814 0.033437684 0.224991712 0.73817161 0.57397136 cgl0261191 MGC39545 403312 2.13794 0.033454254 0.225024024 1.36842051 0.57508068 cg23704082 TRIM 59 286827 2.1377 0.033474043 0.225025282 1.33395851 0.57104679 cg00155485 THRAP2 23389 2.13765 0.033477975 0.225025282 1.33909476 0.58113151 cgl2723809 MGC26744 132989 2.13745 0.033494811 0.225053601 1.34325123 0.56166801 cg00554702 CHEK1 1111 2.13719 0.033516163 0.225053601 1.35087076 0.58713191 cg03503295 DNAH5 1767 -2.13717 0.033517495 0.225053601 0.74220438 0.58254336 cg22445920 SLC36A3 285641 -2.13694 0.033536303 0.225100851 0.74699909 0.59348528
cg00226923 FGD2 221472 -2.1361 0.033605247 0.225238062 0.74602222 0.56383622 cg06953304 N TR 4820 2.1361 0.033605256 0.225238062 1.33816626 0.58163574 cgl0396357 TFAP4 7023 2.1361 0.033605639 0.225238062 1.33891997 0.55400363 cg26164310 LPPR4 9890 2.13599 0.033614706 0.225238062 1.35043361 0.58456031 cg08631437 CKS1A 137529 -2.13597 0.033615988 0.225238062 0.73226031 0.55420533 cg08934427 SLC22A14 9389 -2.13583 0.033627416 0.225238062 0.7362161 0.56444131 eg 19466563 SPARCL1 8404 -2.13567 0.033640405 0.225246169 0.73856413 0.57064341 cg00620629 C6orfll3 221302 2.13544 0.033659859 0.225274028 1.34971951 0.58309802 eg 14789928 RBX1 9978 2.13534 0.033668126 0.225274028 1.34451096 0.57508068 cg01402255 GATAD2B 57459 2.13513 0.033684928 0.225294668 1.34046745 0.59126664 cg00611397 GTPBP5 26164 -2.13492 0.03370243 0.225294668 0.74060665 0.56232352 cg25537962 CD109 135228 2.13487 0.033706555 0.225294668 1.3463595 0.57873639 cg24138639 TEGT 7009 2.13401 0.033777864 0.225383594 1.33228887 0.57013917 cgl5321195 AGPAT3 56894 -2.13398 0.033780506 0.225383594 0.75619162 0.58153489 cg04117029 UROS 7390 -2.13395 0.033782975 0.225383594 0.73974098 0.57613957 cg08509737 ATG7 10533 -2.13394 0.033783831 0.225383594 0.7346561 0.56030658 cg07026910 INPP5D 3635 2.13375 0.033799674 0.225383594 1.32458405 0.58173659 cgl3908518 AMY2B 280 -2.13374 0.033800105 0.225383594 0.74334456 0.56585317 cg24103438 NLGN4X 57502 2.13363 0.03380942 0.225383594 1.35693036 0.57099637 cgl0839521 FU32786 136332 2.13357 0.033814148 0.225383594 1.33757819 0.55854175 cg22083798 IGFBP3 3486 2.1332 0.0338452 0.2254897 1.34323767 0.55052441 eg 11847808 EPHA8 2046 2.13296 0.033865055 0.2254897 1.33242429 0.57538322 cgl l009736 MARCO 8685 2.1329 0.033869575 0.2254897 1.33418653 0.56454215 cg09648228 HNRPC 3183 2.13281 0.033877233 0.2254897 1.33895615 0.58738403 cg22873668 CXorf56 63932 -2.13199 0.033945532 0.225757965 0.74883411 0.57155103 cg25737836 MCM3AP 8888 -2.13197 0.033946825 0.225757965 0.74884374 0.5699879 cg06493930 GAS 2 2620 -2.1319 0.033952954 0.225757965 0.73842321 0.56348326 cg08724636 RALA 5898 2.13108 0.034020881 0.226116541 1.32929499 0.57528237 cg04201526 CRISPl 167 -2.13096 0.034030531 0.226116541 0.74404204 0.56318072
DKFZP686A1
eg 14298726 0121 85865 2.13048 0.034070911 0.226306216 1.3479954 0.57260992 cgl5916061 SLC17A4 10050 -2.1303 0.034086091 0.226328434 0.74580428 0.57175272 cgl7648620 EFHC1 114327 2.13009 0.034103665 0.226339164 1.3477613 0.59449375 cg03059528 RNF146 81847 2.12999 0.034111379 0.226339164 1.34091245 0.58057685 cg03682823 SGCE 8910 -2.12967 0.034138343 0.226376234 0.74369264 0.56585317 cg06638966 COL19A1 1310 2.12964 0.034140642 0.226376234 1.33373898 0.57977007 cg24884084 SPRR1B 6699 -2.12879 0.034211457 0.226694904 0.73637103 0.58082896 cg23407670 MLH3 27030 2.12878 0.034212411 0.226694904 1.34236072 0.58138362 cgl5727249 APOA4 337 -2.12822 0.034259398 0.226927615 0.74268984 0.57336628 cgl7176732 OXR1 55074 2.12807 0.034271643 0.226930116 1.33014169 0.57165188 cg04808672 SMURF2 64750 2.12775 0.034299003 0.227032669 1.33042237 0.57649254 cg00581156 HSA9761 27292 2.12747 0.034322321 0.227070279 1.32481887 0.57866075
cgl l754343 NUP88 4927 2.1274 0.034328433 0.227070279 1.35017561 0.56938282 cg20312687 DEFB118 117285 -2.12688 0.034371784 0.227234783 0.74830051 0.56060912 cg20955688 TMEM71 137835 2.12682 0.034377069 0.227234783 1.34437579 0.56580274 cg00121904 MAOB 4129 -2.12639 0.034412951 0.227281403 0.74517143 0.55743243 cg02224164 ARHGAP9 64333 -2.12632 0.034419121 0.227281403 0.7477362 0.56897943 cg25182523 Clorf24 116496 -2.12631 0.034419777 0.227281403 0.74859531 0.58284591 eg 19799744 ENPP5 59084 2.12596 0.03444945 0.227329263 1.34288249 0.568929 cgl6370389 PTTG2 10744 -2.12594 0.034450801 0.227329263 0.73632265 0.58703106 cg05064352 PHF21B 112885 2.12548 0.034489295 0.227445813 1.33209575 0.57760186 cgl l821536 TTC8 123016 2.12545 0.034492251 0.227445813 1.3337027 0.56706333 cg05755779 COLEC10 10584 -2.12517 0.034515915 0.227481243 0.74557832 0.57750101 eg 16449464 MAP1D 254042 2.1251 0.034521416 0.227481243 1.33289763 0.55682735 cg04428453 FU20581 54988 -2.12462 0.03456189 0.2276695 0.74369522 0.56968536 cg26869604 LRRC20 55222 2.12444 0.034576859 0.227689674 1.33464146 0.56434046 cg00725635 B3GALT2 8707 2.1238 0.034631238 0.227969256 1.33693364 0.58037515 cg08820801 FBX017 115290 2.12269 0.034724769 0.228486971 1.33426718 0.57281162 cg08521225 TTR 7276 -2.12259 0.034733782 0.228486971 0.74929023 0.57336628 cgl2497692 ZBTB32 27033 -2.122 0.034783906 0.228738019 0.74267012 0.5575837 cgl8091964 CXorf9 54440 -2.12147 0.034828835 0.228879328 0.75183122 0.5699879 cg20612615 PREP 5550 2.12137 0.034837037 0.228879328 1.35635077 0.57987092 cgl l241627 FERD3L 222894 2.12128 0.034844323 0.228879328 1.34062856 0.57306374 cgl4705927 P4HA1 5033 2.12114 0.034856896 0.228879328 1.34635501 0.58995563 cg24934431 CYP17A1 1586 -2.12104 0.03486524 0.228879328 0.74394882 0.54734772 cg00832517 C14orfl26 112487 2.12024 0.034933203 0.229246787 1.33300593 0.58329972 cg08085165 NUP37 79023 -2.11922 0.035019991 0.229660921 0.74665114 0.56933239 cgl7699374 MGC35206 339669 2.11921 0.035021186 0.229660921 1.33959062 0.54921339 cg26229648 CNTF 1270 -2.11907 0.035032339 0.229660921 0.74356465 0.56555063 cg00571634 WDR5B 54554 2.11891 0.035046423 0.229674517 1.3439268 0.56968536 cgl8811423 PNPT1 87178 2.11861 0.035071716 0.229695007 1.35643338 0.57225696 cg03771255 RPS3A 6189 2.11859 0.035073573 0.229695007 1.33647099 0.59086325 cgl3936125 GNAOl 2775 2.11836 0.035092978 0.229743413 1.33725234 0.56217225 cgl6438432 HNRPD 3184 2.11777 0.03514358 0.229995952 1.33898038 0.56544978 cgl ll39878 CD5L 922 -2.11736 0.035178641 0.230145528 0.7527339 0.58037515 cgl2337114 TAS2R3 50831 -2.11722 0.035190506 0.230145528 0.73873769 0.57543364 cg00359325 USP4 7375 -2.11708 0.035202936 0.23014811 0.75330018 0.57845906 cg06233985 HBB 3043 -2.1166 0.035243782 0.230336405 0.74721353 0.56186971 cg00256074 MYLPF 29895 -2.11637 0.035263843 0.230387228 0.74178144 0.5637858 cg05801573 SLITRK4 139065 2.11623 0.035275654 0.230387228 1.33615607 0.58602259 cgl4700821 ADAMTS6 11174 2.11591 0.035303327 0.230489246 1.36133512 0.57951795 cg25124433 KRT20 54474 -2.11571 0.035320716 0.230492424 0.74968511 0.55955022 cg23970089 ATP5I 521 2.11547 0.035340756 0.230492424 1.33410886 0.54991932 cg00661485 FOXI1 2299 2.11538 0.035348928 0.230492424 1.34457927 0.58466115
cg23818978 AMICA1 120425 2.11533 0.035352972 0.230492424 1.33570313 0.58380395 cg05245515 SLC39A2 29986 -2.1152 0.03536408 0.230492424 0.74403354 0.57114764 cg25559100 CSNK2A1 1457 2.11463 0.03541293 0.230732175 1.33224376 0.56882816 cg26372557 TICAM 1 148022 -2.11423 0.03544797 0.230812953 0.74716283 0.57044171 cg21363706 NAT1 9 -2.11421 0.035449468 0.230812953 0.74046263 0.57089552 cg20356482 FBP2 8789 -2.1135 0.035510586 0.231030831 0.74432905 0.56973578 cg06445611 GABRR2 2570 -2.11332 0.035526103 0.231030831 0.74435431 0.58007261 cgl8678763 RRM 1 6240 2.11328 0.035529922 0.231030831 1.34054712 0.56797096 cgl7177699 COL5A3 50509 -2.11305 0.035549147 0.231030831 0.74967987 0.56731545 cg08659707 PUM2 23369 -2.11269 0.035580679 0.231030831 0.74436822 0.57439996 cgl8763191 ST3GAL5 8869 2.11242 0.035604123 0.231030831 1.34443856 0.58062727 cg24459209 PRG3 10394 -2.11215 0.035626999 0.231030831 0.74680933 0.5830476 cgl6046376 PC 5091 -2.11214 0.035628688 0.231030831 0.75568168 0.57250908 eg 10457895 RSRC1 51319 2.11201 0.035639388 0.231030831 1.33849315 0.58098023 cg00941549 AKAP4 8852 -2.11189 0.035650035 0.231030831 0.74388364 0.56943324 cgl4384532 NTRK3 4916 -2.11183 0.035655381 0.231030831 0.73718484 0.5796188 cgl7812431 UMOD 7369 -2.11179 0.035658878 0.231030831 0.74949498 0.57079468 cgl0187932 PARP11 57097 2.11178 0.035659789 0.231030831 1.33803728 0.5753328 cg07290435 CDH10 1008 2.1117 0.035666224 0.231030831 1.33304194 0.56736587 cg07730329 PCDHGA12 26025 2.11091 0.035734854 0.231030831 1.33903377 0.56081081 cg23328404 ChGn 55790 2.11078 0.035745759 0.231030831 1.33601089 0.55944938 cg21329628 CD320 51293 2.11069 0.035753795 0.231030831 1.32237094 0.58395522 cg08946117 MGC50273 408029 -2.11067 0.035755981 0.231030831 0.74671733 0.56197055 cgl l577097 AQP9 366 -2.11058 0.035763609 0.231030831 0.74749916 0.58115672 cg24429836 LDHD 197257 -2.11056 0.035765098 0.231030831 0.75270314 0.55884429 cg23578193 LGR6 59352 2.11039 0.035779922 0.231030831 1.32416188 0.55445744
DKFZP686A1
cgl l909310 0121 85865 2.11016 0.035799679 0.231030831 1.32707536 0.564643 cg05663262 HYI 81888 -2.10997 0.035816566 0.231030831 0.75466366 0.56706333 cgl5641998 DHRS8 51170 2.10986 0.03582624 0.231030831 1.33971249 0.57573618 cg09169283 GRIN2C 2905 2.1097 0.035839718 0.231030831 1.31467088 0.58355184 cg22451189 MRPS22 56945 2.10966 0.03584338 0.231030831 1.33876575 0.5866781 cg05026033 ELP3 55140 2.10955 0.035853245 0.231030831 1.34307261 0.55027229 cgl5272690 HSPC065 29070 2.10944 0.035862222 0.231030831 1.33207952 0.56812223 cg00516481 PDE9A 5152 2.10944 0.035862897 0.231030831 1.32399905 0.57442517 cg07154408 PDE5A 8654 2.10939 0.035866652 0.231030831 1.34716092 0.5592981 cg08748415 CLIC5 53405 -2.10929 0.035875824 0.231030831 0.74872785 0.5481545 cg21347412 STAP2 55620 -2.10916 0.035886874 0.231030831 0.74859605 0.56671037 cgl l243196 ADAMTS3 9508 2.10893 0.035906728 0.231030831 1.34748413 0.57442517 cg03876622 CSDA 8531 2.10885 0.035913719 0.231030831 1.33635444 0.5796188 cg06985415 C10orf39 282973 2.10873 0.035924608 0.231030831 1.33853083 0.58234167 cg08918431 MASK-BP3 404734 2.1085 0.035944803 0.231030831 1.32336415 0.580476
cgl9133903 AVPI1 60370 2.10836 0.035956846 0.231030831 1.32263561 0.57376967 eg 10534672 C1QTNF2 114898 2.10832 0.035959924 0.231030831 1.32745324 0.56494554 cg26266326 GCG 2641 -2.10826 0.035965295 0.231030831 0.74610796 0.56103772 cg09065199 ASXL1 171023 2.10825 0.035966418 0.231030831 1.33012393 0.56877773 cg24515202 TTC9C 283237 2.10803 0.035985306 0.231030831 1.34204173 0.56277733 cgl5676488 SNRPC 6631 2.10798 0.035990348 0.231030831 1.33735153 0.56101251 cgl l058932 TSGA13 114960 2.10764 0.036019665 0.231083425 1.32513259 0.56454215 cg06386533 SOCS5 9655 2.1076 0.036022709 0.231083425 1.32000842 0.55667608 cg20953047 PIGR 5284 -2.10721 0.03605706 0.231149898 0.74552015 0.5708451 cg03760483 ALOX12 239 2.10704 0.036072279 0.231149898 1.33751907 0.5796188 cg22751696 C3orfl4 57415 2.10698 0.036077719 0.231149898 1.3328951 0.56534893 cgl l735605 ZNFN1A2 22807 2.10665 0.03610654 0.231149898 1.35288753 0.57145018 cgl9863405 ACTL7B 10880 -2.10658 0.036112751 0.231149898 0.73986388 0.58859419 eg 16068780 SBNOl 55206 -2.10647 0.036121701 0.231149898 0.73823275 0.56524808 cgl7891149 SHC1 6464 2.10632 0.036134982 0.231149898 1.34327028 0.5642144 cgl2936220 RPL26L1 51121 2.1062 0.036145706 0.231149898 1.32278169 0.55395321 cg06461848 WDR64 128025 -2.10616 0.036149417 0.231149898 0.75303889 0.56688685 cgl6434306 FU 14054 79614 -2.10611 0.036153947 0.231149898 0.75470203 0.58143405 cg06505666 FU40629 150468 2.1051 0.036242564 0.231432807 1.32064183 0.58577047 cg02512226 ARMC4 55130 2.10488 0.036261767 0.231432807 1.34288003 0.55859217 cg09667582 UBE2Q2 92912 2.10484 0.036264773 0.231432807 1.33428245 0.57382009 cg09778734 FU40142 400073 -2.10481 0.036267658 0.231432807 0.75030321 0.57044171 cgl3282837 TCL1A 8115 2.10468 0.036278654 0.231432807 1.33696996 0.53005244 cg20483016 TTC5 91875 2.10457 0.036288428 0.231432807 1.33939121 0.58108108 cgl7963840 ADRA1A 148 -2.10455 0.036290722 0.231432807 0.74959449 0.5839048 cg26661897 RTCD1 8634 2.10448 0.036296549 0.231432807 1.32525975 0.55657523 eg 16240480 EDARADD 128178 2.10436 0.036307118 0.231432807 1.33319121 0.56212182 cg25780543 HTR5A 3361 2.10421 0.036320108 0.231438464 1.31947135 0.58269464 cg25048564 HUNK 30811 2.10379 0.036357379 0.231495498 1.32539491 0.57926583 cg23519969 CCR8 1237 -2.10369 0.036366613 0.231495498 0.73868005 0.5796188 cg l4331163 RORB 6096 2.10342 0.036390256 0.231495498 1.35882826 0.56111335 cg00184893 ALOXE3 59344 2.10341 0.036390568 0.231495498 1.32895292 0.57654296 cg01402045 FU23356 84197 2.10338 0.036393197 0.231495498 1.32573428 0.54860831 eg 10938486 FU20581 54988 -2.10329 0.036401692 0.231495498 0.75323096 0.56857604 cg08662074 PAPPA 5069 2.10308 0.03641993 0.231534479 1.33847653 0.57346712 cg00165981 CO L4 A3 BP 10087 2.10289 0.036436795 0.231564717 1.34066091 0.57886245 cgl3283751 GPX5 2880 2.1022 0.036497437 0.231805302 1.35010088 0.57044171 cgl6792160 ASAH2 56624 -2.10204 0.036511674 0.231805302 0.73843493 0.57472771 eg 17769158 ODF1 4956 -2.10203 0.036513071 0.231805302 0.74839914 0.57422348 cg02630105 PRKCD 5580 2.10161 0.036550089 0.231805302 1.32290466 0.56706333 cg03278643 EVC2 132884 -2.10154 0.036556204 0.231805302 0.75576528 0.57558491 cgl l021744 SLC6A1 6529 2.10151 0.036558406 0.231805302 1.32034097 0.5813332
cgl9339841 CENPE 1062 2.1015 0.036559504 0.231805302 1.34908801 0.57911456 cg01333011 PTHLH 5744 2.10101 0.036603034 0.23192785 1.34688453 0.57901372 cg23806715 H3F3B 3021 2.1009 0.0366125 0.23192785 1.3307394 0.56449173 cgl l452221 GEFT 115557 2.10079 0.036622258 0.23192785 1.32960987 0.57104679 eg 17961200 CEL 1056 -2.10061 0.036638367 0.23192785 0.74662626 0.56671037 cgl6636571 GYPB 2994 -2.10054 0.036644384 0.23192785 0.75637421 0.57356797 cgl l956146 CABYR 26256 2.10046 0.036651602 0.23192785 1.33606549 0.57780355 cgl5364537 MFSD4 148808 2.09989 0.036701935 0.232169526 1.31906981 0.5744756 cgl9139729 SULT2A1 6822 -2.09939 0.03674694 0.232257067 0.74737578 0.57977007 cg03264209 CREBBP 1387 2.09904 0.036777477 0.232257067 1.32442735 0.5841065 cg00237010 NINJ2 4815 -2.09903 0.036778937 0.232257067 0.74735926 0.5515833 cgl7925436 PALLD 23022 -2.09892 0.03678884 0.232257067 0.7490934 0.57495462 cg06470471 LRTM 1 57408 -2.09866 0.03681122 0.232257067 0.74926324 0.5751311 cg04605667 SIAH2 6478 2.09842 0.036833041 0.232257067 1.34753806 0.55597015 cgl l025793 STX10 8677 2.09829 0.036844788 0.232257067 1.34503546 0.55955022 cgl5648905 RPL12 6136 2.09822 0.036850674 0.232257067 1.32467599 0.55914683 cg04443324 FAT2 2196 -2.09819 0.036853469 0.232257067 0.74978613 0.56676079 cg05776763 DLST 1743 -2.09801 0.036869963 0.232257067 0.75229344 0.59661154 cg08347423 IIWS 27130 2.098 0.036870417 0.232257067 1.33064774 0.57982049 cgl8470891 F0XM1 2305 -2.0975 0.036914947 0.232257067 0.75314641 0.56852562 cg06836849 SLC17A8 246213 2.09711 0.03694941 0.232257067 1.32943026 0.57104679 cg00567749 CSPG2 1462 2.09696 0.03696356 0.232257067 1.33407025 0.57760186 cgl3264741 GRIN2B 2904 2.09692 0.036966766 0.232257067 1.32787079 0.56948366 cg24264578 0R2C1 4993 -2.09656 0.036999181 0.232257067 0.74751534 0.57936668 cg05612904 DPH5 51611 2.09615 0.037035643 0.232257067 1.33903941 0.59101452 cgl8905252 CFC1 55997 2.09613 0.037037308 0.232257067 1.32977435 0.57740016 eg 11326640 STAU 6780 2.09612 0.037038059 0.232257067 1.34519042 0.56136547 cg25202404 PXMP3 5828 2.09606 0.037043642 0.232257067 1.32813315 0.58244252 eg 17048483 RBM7 10179 2.09606 0.037044106 0.232257067 1.34505511 0.56499597 eg 19596204 ISYNA1 51477 2.09584 0.03706317 0.232257067 1.33114824 0.54240621 cg24946408 PPP1R15A 23645 2.09583 0.037064642 0.232257067 1.31498134 0.57407221 cg09721047 ARHGAP25 9938 2.09572 0.037074267 0.232257067 1.33777095 0.56338241 eg 18567470 ARHGEF12 23365 2.09551 0.037092628 0.232257067 1.32829517 0.5759883 cgl3878093 TBPL1 9519 2.09546 0.037097859 0.232257067 1.33280951 0.55637354 cg25438415 ZNF426 79088 2.09534 0.037108508 0.232257067 1.32512968 0.58783784 cg27336379 SLC44A5 204962 -2.09531 0.03711053 0.232257067 0.74457629 0.57830779 cg22036233 ZFYVE26 23503 2.0953 0.037111384 0.232257067 1.32526228 0.56045785 cg03460682 CYP27A1 1593 2.0953 0.03711197 0.232257067 1.34395814 0.57624042 cg04754011 GPR44 11251 2.09506 0.037133541 0.232257067 1.32604296 0.57260992 cg23099349 HIST1H3B 8358 2.09498 0.037140265 0.232257067 1.32768031 0.57583703 cg08009831 LOC201895 201895 2.09496 0.037142231 0.232257067 1.32937858 0.58158532 cg01137065 F0XK2 3607 2.09489 0.037148494 0.232257067 1.32633207 0.55697862
cgl7910564 VDAC3 7419 -2.09473 0.037162801 0.232257067 0.7550675 0.57689593 cgl3216088 PSMD1 5707 2.09473 0.037163019 0.232257067 1.32521075 0.57039129 cg05511685 RGS9 8787 -2.09459 0.037175557 0.232257067 0.75030641 0.58798911 cg22854223 CD82 3732 2.09446 0.037187177 0.232257067 1.32091396 0.57982049 cg01651593 CDC20 991 2.09433 0.03719841 0.232257067 1.33950319 0.58415692 cg00930194 PROP1 5626 2.09391 0.037236694 0.232257067 1.34281721 0.59217426 cgl8349258 SMEK2 57223 2.09382 0.037244488 0.232257067 1.32429141 0.57129891 cg02376163 FBX038 81545 2.09372 0.037253479 0.232257067 1.33483637 0.57215611 cg03623878 MCF2L 23263 2.09364 0.037260553 0.232257067 1.32858484 0.57407221 cgl0364513 RXRG 6258 2.09359 0.037265316 0.232257067 1.33154343 0.58450988 cgl8641937 ITLN2 142683 -2.09345 0.037278287 0.232257067 0.73796203 0.56151674 cg07243519 UFM 1 51569 2.09333 0.037289051 0.232257067 1.33393337 0.57276119 eg 14243026 HMP19 51617 2.09294 0.037323876 0.232257067 1.33294082 0.58854377 eg 19824441 ADMR 11318 -2.09293 0.03732449 0.232257067 0.75358828 0.55753328 cg21051086 PPP4R2 151987 -2.0928 0.03733666 0.232257067 0.74616138 0.55818879 cgl8568838 MRPS10 55173 2.09276 0.037339711 0.232257067 1.34300308 0.5770472 cgl8107827 ZNF593 51042 2.09271 0.037344237 0.232257067 1.32817854 0.56771884 cgl8372353 ATPBD4 89978 2.09243 0.037370005 0.232257067 1.33479672 0.56439088 eg 14408969 C8orf40 114926 2.09232 0.037380093 0.232257067 1.32177474 0.54996975 cg08527127 Clorf94 84970 -2.09228 0.037383032 0.232257067 0.7447837 0.55818879 cgl6688376 AKAP9 10142 2.09228 0.037383775 0.232257067 1.32735528 0.56701291 cg21639401 FU31222 388387 -2.09206 0.037403612 0.232271364 0.74261758 0.56302945 cg07128330 MDS028 55846 2.09192 0.037415924 0.232271364 1.33105116 0.57619 cg06453691 FU32206 149421 -2.09177 0.037429131 0.232271364 0.74575685 0.57366882 cg21932814 CSTA 1475 2.09171 0.037434661 0.232271364 1.33629017 0.55279347 cg04394967 RDH12 145226 2.09148 0.037455109 0.23232286 1.33229691 0.57124849 cg06297145 NFXL1 152518 2.09122 0.037479118 0.232338899 1.33563058 0.59126664 cg08341874 VMOl 284013 2.09119 0.037481995 0.232338899 1.33406925 0.57271077 cg22024657 SLC13A1 6561 -2.0907 0.037526391 0.232445845 0.74904856 0.54881 cgl7484237 HAVCR2 84868 2.09042 0.037551349 0.232445845 1.33179316 0.57225696 cg07398429 MAGEB4 4115 -2.09038 0.037555509 0.232445845 0.75791036 0.56660952 cg01602416 GCSH 2653 2.08992 0.037596681 0.232445845 1.32512116 0.57866075 cg01063813 STAT6 6778 2.08988 0.037600134 0.232445845 1.33023526 0.57124849 cgl7400229 U2AF1 7307 2.08975 0.037612165 0.232445845 1.32258068 0.5708451 cg04286043 C6orf69 222658 2.08956 0.037628932 0.232445845 1.33688098 0.57089552 cg04249586 ELOVL6 79071 2.08948 0.03763646 0.232445845 1.32343748 0.55939895 cg23032316 AAAS 8086 2.08946 0.037638473 0.232445845 1.33213279 0.58148447 cg09685104 C18orfl9 125228 2.08929 0.03765376 0.232445845 1.32869722 0.56479427 cg20185083 SERPINB9 5272 -2.08924 0.037658385 0.232445845 0.7575118 0.56776926 cgl4665389 TCF7L2 6934 2.08911 0.037670425 0.232445845 1.32338011 0.56217225 cg03752087 CASP14 23581 -2.08909 0.037671755 0.232445845 0.74669833 0.57331585 cg02250787 HTR2A 3356 2.08905 0.037675286 0.232445845 1.32967509 0.58940097
cgl4228238 EVI1 2122 2.08898 0.037681578 0.232445845 1.32337699 0.5663574 cg22468055 PARP15 165631 -2.08873 0.037704341 0.232470343 0.750676 0.56625656 cgl l435943 SERPINB12 89777 -2.08856 0.037720441 0.232470343 0.75144295 0.57316458 cg05190718 CASQ2 845 -2.08839 0.037735944 0.232470343 0.75040426 0.56756757 cgl2315997 RPL9 6133 2.08813 0.037759288 0.232470343 1.33304888 0.57099637 cg20537325 MGMT 4255 -2.08809 0.037762642 0.232470343 0.7441994 0.57664381 cgl0224037 ZNF354A 6940 2.08807 0.037764968 0.232470343 1.32486868 0.55642396 cg24793470 GOSR1 9527 2.08801 0.037770646 0.232470343 1.32596659 0.57535801 cg24091474 TYRO BP 7305 2.08726 0.03783896 0.232803805 1.32877981 0.56504639 cgl2925542 WDR49 151790 -2.08714 0.037849173 0.232803805 0.75227596 0.58972872 cgl7351385 ALKBH6 84964 2.08694 0.037867453 0.232841353 1.3330895 0.57407221 cg26147657 FU13946 92104 2.08672 0.037888096 0.232869103 1.32296027 0.56469343 cg21973800 CINP 51550 2.08663 0.037896322 0.232869103 1.33923511 0.5858209 cg25041439 HYLS1 219844 -2.08635 0.037921267 0.232947536 0.75409612 0.57334107 cg23519022 CAPZB 832 -2.08576 0.03797579 0.233064673 0.75360491 0.55682735 cgl9081759 YWHAQ 10971 -2.08573 0.037978097 0.233064673 0.75458362 0.57679508 cg24338843 Clorfl58 93190 -2.08561 0.03798958 0.233064673 0.74014654 0.56020573 cgl5873633 ZNF37A 7587 2.08545 0.038004197 0.233064673 1.33587902 0.56474385 cg03787486 ADH5 128 2.08538 0.038010297 0.233064673 1.32821054 0.5672146 cg00915206 GAD1 2571 2.08534 0.038013462 0.233064673 1.33479566 0.57815652 cgl6666115 MRPS18A 55168 2.08494 0.038050228 0.233215317 1.32947483 0.54966721 cgl8895972 PELO 53918 2.08462 0.038079547 0.233320236 1.32386845 0.56555063 cg03634997 GAS8 2622 2.08433 0.03810649 0.233410534 1.3343638 0.55919726 cg03919781 EFHA2 286097 2.0841 0.038127874 0.233466733 1.33944581 0.57997176 cg01169610 I PP4A 3631 -2.08388 0.038147701 0.23347379 0.75071908 0.57306374 cg07964538 CAV1 857 2.08382 0.038153445 0.23347379 1.33563701 0.60321702 cg09619786 RPP25 54913 2.08365 0.038169054 0.233494591 1.34316199 0.56348326 cgl2645567 TFAP4 7023 2.08321 0.038209325 0.233503216 1.32300724 0.55712989 cgl3794888 RNUT1 10073 2.08293 0.038235132 0.233503216 1.32009826 0.56565147 cgl5597540 CYB561D2 11068 -2.08289 0.038238297 0.233503216 0.757307 0.57175272 cg04531710 EIF4G1 1981 -2.08287 0.03824014 0.233503216 0.75305048 0.57407221 eg 14696348 MC1R 4157 2.08283 0.038243726 0.233503216 1.32582251 0.54104478 eg 19674669 LOC112937 112937 2.08283 0.038243728 0.233503216 1.32418368 0.56751714 cgl6862838 RCN2 5955 -2.08246 0.038277893 0.23356692 0.74807122 0.56098729 cg22606869 TUBA6 84790 2.08246 0.038278589 0.23356692 1.32486974 0.5567265 cg01120308 PICALM 8301 2.08206 0.038315268 0.233716152 1.33366318 0.56338241 cg24254120 RFC 3 5983 2.08161 0.038356317 0.233744496 1.33031363 0.55934853 eg 10669058 CILP2 148113 2.08133 0.038382638 0.233744496 1.32071704 0.57392094 cg00600684 BRWD2 55717 -2.08132 0.038383594 0.233744496 0.74849028 0.57492941 eg 19690404 CPA4 51200 -2.0813 0.038384973 0.233744496 0.75135142 0.56653389 cgl6273524 THUMPD2 80745 -2.08112 0.038401736 0.233744496 0.74829156 0.5717023 cgl5056247 TSPYL1 7259 2.08083 0.038428272 0.233744496 1.32901897 0.57503025
cg05218490 ORC4L 5000 2.08083 0.038428795 0.233744496 1.35010219 0.5768455 cg09805010 THRB 7068 2.08076 0.038435037 0.233744496 1.3261636 0.57034086 cg04520084 CCNC 892 2.08057 0.038452372 0.233744496 1.32796404 0.58274506 cg09068492 CALCA 796 2.08028 0.038479507 0.233744496 1.34540037 0.57936668 cg00804392 RHOH 399 2.08019 0.038487639 0.233744496 1.337044 0.57699677 cg04502814 SEPP1 6414 2.08018 0.038488349 0.233744496 1.33858284 0.56726503 cg24776019 HYPB 29072 -2.08005 0.038500284 0.233744496 0.73672644 0.56116378 eg 14462830 TRDN 10345 -2.08004 0.038501629 0.233744496 0.75900663 0.58183743 cgl4911472 CRSP3 9439 2.07989 0.038515306 0.233744496 1.33472365 0.57276119 cg04563996 SPATA12 353324 2.07989 0.038515487 0.233744496 1.33379597 0.56882816 cg01794265 FAM 105A 54491 -2.07888 0.038608554 0.234115797 0.74888936 0.58022388 cg26316946 GRIK2 2898 2.07881 0.038615392 0.234115797 1.33811743 0.55284389 cgl4085328 DDX59 83479 2.07872 0.038623814 0.234115797 1.3337294 0.57205526 eg 11565248 RPS6KA3 6197 -2.0787 0.038625639 0.234115797 0.74982221 0.55481041 cg26265187 USP52 9924 -2.0784 0.03865308 0.234207887 0.74783358 0.5592981 cgl9465374 AZGP1 563 -2.07818 0.038674007 0.234260462 0.75355583 0.57079468 cg07259382 Mar-01 55016 -2.07789 0.038700345 0.234345769 0.73449704 0.56459258 cg04464559 PDSS2 57107 2.07768 0.038720147 0.234391455 1.33749744 0.58526624 cgl8675600 PTP4A3 11156 -2.07725 0.038759853 0.234496954 0.7541569 0.56242437 cgl7774418 FU33708 285780 -2.07719 0.038766056 0.234496954 0.75594977 0.5736184 cg26889928 TRIM 24 8805 -2.07698 0.038785779 0.234496954 0.74776591 0.56287818 cg26174752 GPR63 81491 2.07689 0.038793892 0.234496954 1.32074633 0.57079468 cgl5677294 TUBB4 10382 -2.07671 0.038810261 0.234496954 0.75610956 0.56161759 cg27412902 IL29 282618 -2.07667 0.038814283 0.234496954 0.74036579 0.5637858 cgl2438666 C2orfl5 150590 2.07642 0.038837957 0.234496954 1.33635027 0.55753328 cg04981492 SYDE1 85360 2.07634 0.038845246 0.234496954 1.33650817 0.54956636 cg09258965 TBC1D7 51256 -2.07631 0.038847938 0.234496954 0.74447188 0.5567265 cgl6918585 NDUFS5 4725 2.07602 0.038875059 0.234557585 1.32783515 0.56514724 cgl2113819 THRAP2 23389 2.07594 0.038882515 0.234557585 1.32567956 0.56958451 cg04172348 SY 2 6854 2.07531 0.038940773 0.234768758 1.31354591 0.56776926 cg02992647 DDX52 11056 -2.075 0.038970501 0.234768758 0.75328206 0.56338241 cg08970694 HBE1 3046 -2.07492 0.038977597 0.234768758 0.74890529 0.5672146 cgl5664067 RASA1 5921 2.07491 0.038978242 0.234768758 1.32749872 0.57868596 cg25420398 RYK 6259 2.07491 0.038978905 0.234768758 1.32653682 0.55581888 cgl0562586 MAP2 4133 2.07471 0.03899696 0.234803552 1.34565443 0.58385438 cg01045423 GLMN 11146 2.07445 0.03902161 0.234878014 1.3265916 0.57271077 eg 14287742 BLZF1 8548 -2.07424 0.039041244 0.234883455 0.74234758 0.57745059 cg23864823 MRPL9 65005 2.07418 0.039047079 0.234883455 1.33794475 0.56620613 cgl8112431 CDADC1 81602 2.07348 0.039112376 0.235052052 1.31784345 0.56756757 cg07817698 DHODH 1723 2.07334 0.039125747 0.235052052 1.33322533 0.5744756 cg25739003 EEF1G 1937 -2.07315 0.0391432 0.235052052 0.75702721 0.56005446 cgl5937081 C14orfl06 55320 2.07303 0.039154842 0.235052052 1.33322836 0.56408834
cg01727899 GPATC2 55105 -2.07293 0.039163872 0.235052052 0.75493066 0.57518153 cg25841987 C4orfl8 51313 2.07287 0.03916976 0.235052052 1.34263899 0.57039129 cg23179321 RPP38 10557 2.07277 0.039178854 0.235052052 1.33802976 0.56681121 cgl0173675 RAB17 64284 -2.07273 0.039182922 0.235052052 0.76019785 0.5699879 cgl3118849 CSPG3 1463 -2.0727 0.039185731 0.235052052 0.76173295 0.56781969 cg21818252 SEC24B 10427 2.07256 0.039198434 0.235054515 1.32157847 0.56318072 cgl5278682 TACR2 6865 -2.07204 0.03924769 0.235239141 0.75010137 0.57714804 cg02910574 PCOLN3 5119 -2.07171 0.0392783 0.235239141 0.7564552 0.53625454 cgl3843773 MGC35043 255119 2.07162 0.039286925 0.235239141 1.3237113 0.58693021 cgl0791260 TNFSF15 9966 2.07162 0.039287517 0.235239141 1.32777971 0.56212182 cgl8679190 MFAP2 4237 -2.07158 0.03929073 0.235239141 0.75548793 0.56928197 eg 16104446 MCM4 4173 -2.07119 0.039328054 0.235243741 0.75169361 0.56101251 cg21061811 DDA1 79016 -2.07114 0.039332372 0.235243741 0.7437558 0.56025615 cg23126947 NSUN3 63899 -2.07106 0.039339969 0.235243741 0.75210835 0.56560105 cgl l228872 CALR 811 2.07105 0.039340705 0.235243741 1.31137065 0.55622227 cg08823182 S100A5 6276 -2.0708 0.039364508 0.235292503 0.76114105 0.57472771 cgl2727795 PDGFRB 5159 2.07053 0.039389658 0.235292503 1.3312807 0.56918112 eg 18579447 MAP2K1IP1 8649 2.07049 0.039394047 0.235292503 1.33916431 0.5802743 cgl7751867 GOLPH3 64083 2.07044 0.039398076 0.235292503 1.32451164 0.57371924 cgl6834187 BRD7 29117 -2.07014 0.039427012 0.235367055 0.75314776 0.56517245 cg06911113 UBXD3 127733 2.06997 0.03944258 0.235367055 1.32024434 0.55228923 cg00688421 RAPIGDSI 5910 -2.0699 0.039449454 0.235367055 0.75172894 0.57150061 cg21885525 SCYE1 9255 2.06979 0.039459792 0.235367055 1.32900692 0.56731545 cg06074920 KRTHA4 3885 -2.06934 0.039501872 0.235466795 0.75538117 0.55143203 cg22718139 HMGCS2 3158 -2.06914 0.039520973 0.235466795 0.74712 0.57276119 cgl9985911 AVIL 10677 -2.06911 0.039523694 0.235466795 0.75417536 0.56247479 cg05615150 ARPP-21 10777 -2.06909 0.039525767 0.235466795 0.75129193 0.5794171 cgl2775613 HTR1F 3355 -2.06866 0.039566805 0.235616833 0.75185926 0.54396934 cg09173897 KIAA1622 57718 2.06856 0.039575595 0.235616833 1.31890728 0.57230738 cg26053864 ACTC 70 2.068 0.039628887 0.235860683 1.32093759 0.56701291 cgl7639290 TIMM8B 26521 2.06783 0.039645133 0.235883961 1.32024446 0.56605486 cg25391023 BTNL2 56244 -2.06718 0.039707178 0.236120222 0.75930181 0.57139976 cgl0995359 LYCAT 253558 -2.06715 0.039709537 0.236120222 0.73645721 0.57402178 cg22534509 GPR81 27198 -2.06667 0.039754973 0.236171549 0.74775475 0.58556878 cgl9308222 EREG 2069 2.06664 0.039757811 0.236171549 1.33377355 0.57276119 cgl5271616 RUSC2 9853 2.06659 0.039763052 0.236171549 1.3210559 0.55889472 cgl3605579 ALPP 250 -2.06642 0.039779059 0.236171549 0.74844692 0.54785196 cgl6761041 C9orflOOS 158293 2.06639 0.039781643 0.236171549 1.32731099 0.57175272 cgl l075556 ANKRD7 56311 -2.06615 0.0398046 0.236171549 0.75251114 0.56872731 cg07656391 LOC84661 84661 2.06615 0.03980462 0.236171549 1.32177317 0.55470956 cg03665457 LOC158160 158160 -2.06574 0.039843941 0.236323995 0.76005854 0.57931626 cg20932053 CPM 1368 -2.06562 0.03985503 0.236323995 0.75116197 0.56388665
cg01618304 Cllorf54 28970 2.06511 0.03990382 0.236539957 1.32212477 0.56645825 cg06248182 ERAL1 26284 2.06417 0.03999324 0.236944606 1.32925318 0.57240823 cg27160701 SBEM 118430 -2.06414 0.039996865 0.236944606 0.75668348 0.56706333 cgl7165760 AINKRD26 22852 2.06378 0.040031371 0.237001746 1.32448735 0.57013917 cg20977411 PMVK 10654 2.06365 0.040043124 0.237001746 1.32223474 0.55985276 cg09527021 TADA1L 117143 2.06365 0.040043691 0.237001746 1.32434926 0.580476 cg23807646 SLC26A8 116369 2.06334 0.040072672 0.237057876 1.3099244 0.56761799 cgl2085225 SETX 23064 2.06324 0.040082328 0.237057876 1.32090497 0.55264219 cg04457481 GNAS 2778 2.06316 0.040090364 0.237057876 1.3292649 0.56439088 cg23064554 CTRC 11330 -2.06277 0.04012809 0.237207602 0.75689191 0.57719847 cg05146762 GTF2IRD1 9569 2.06206 0.04019616 0.237414212 1.32986608 0.56106293 cgl l043092 MCPH1 79648 -2.06203 0.040198199 0.237414212 0.75419482 0.57485377 cgl8973389 NUP35 129401 2.06182 0.040218874 0.237414212 1.33501331 0.57145018 cg09954385 ARHGAP8 23779 2.06159 0.040241147 0.237414212 1.31642141 0.58899758 cg26128092 WDR8 49856 2.06155 0.040244627 0.237414212 1.30415511 0.57669423
RP11- cg21655480 450P7.3 257240 -2.0615 0.040249408 0.237414212 0.7590374 0.56676079 cgl5798530 TRPC3 7222 -2.0615 0.040249948 0.237414212 0.75842962 0.57089552 cgl8901940 FU14437 84665 -2.06112 0.040286261 0.237473246 0.7555486 0.57286204 cg08793459 PTRH2 51651 2.06089 0.040308039 0.237473246 1.34244662 0.58148447 cg09015232 SLC12A5 57468 -2.06084 0.040313372 0.237473246 0.75401546 0.56726503 cg27126442 FU20184 54848 -2.06055 0.040340419 0.237473246 0.75173404 0.57840863 cgl8833140 HABP2 3026 -2.06043 0.040352107 0.237473246 0.74912773 0.5725595 cg06832950 SPG3A 51062 -2.06034 0.040360601 0.237473246 0.74677754 0.57281162 cgl4758526 CASP5 838 -2.06023 0.040372129 0.237473246 0.74604121 0.55571803 cg06987504 EIF3S6 3646 2.06016 0.040378396 0.237473246 1.32223774 0.57044171 cg27298262 MGC3101 79007 -2.06006 0.040387682 0.237473246 0.7551494 0.568929 cg03482087 MGC33302 256471 2.05997 0.040396388 0.237473246 1.32591388 0.5708451 cg21279601 DRD5 1816 -2.05988 0.040405177 0.237473246 0.75202917 0.5541549 cg26294551 GP5 2814 -2.05975 0.040417476 0.237473246 0.75460641 0.56746672 cg21975377 FZD6 8323 2.05971 0.040421393 0.237473246 1.31721516 0.54946551 cg04668164 SMAP1L 64744 2.05934 0.040457346 0.237611466 1.32678034 0.58481242 cgl2585282 PABPC4 8761 2.05914 0.040477266 0.237613931 1.32446936 0.5541549 cg27138018 HAPLN2 60484 2.05898 0.040492506 0.237613931 1.3353085 0.55985276 cg06392426 FU 12949 65095 2.05895 0.040495042 0.237613931 1.33606791 0.56439088 cg07882535 TRPM5 29850 -2.05866 0.040523318 0.237706907 0.75188391 0.55763413 cgl5895197 EMILIN1 11117 2.05848 0.040540746 0.237736214 1.31674433 0.58657725 cg04820387 PCMTD2 55251 2.05827 0.040560724 0.237780447 1.33544951 0.57452602 cg25908985 IHH 3549 2.05808 0.040579389 0.237816966 1.32423877 0.56751714 cgl4197923 FGF5 2250 2.05765 0.040620666 0.237985935 1.32561867 0.56444131 cgl8676393 GEMIN6 79833 2.05718 0.04066643 0.238082402 1.32024183 0.57926583 cg00690049 MAGED2 10916 -2.05706 0.040677863 0.238082402 0.75240309 0.56736587
cgl9252956 D0CK8 81704 2.05693 0.040690928 0.238082402 1.32720522 0.55546591 cg22979433 C MT2 1160 2.05685 0.040698538 0.238082402 1.32602797 0.56176886 cg00658007 Clorf36 343035 2.05676 0.040707569 0.238082402 1.32139241 0.5725595 cg04091078 SLC01C1 53919 -2.05671 0.040711832 0.238082402 0.74755875 0.57649254 cg04950789 E2F5 1875 2.05629 0.040753146 0.238212323 1.32047734 0.58067769 cg20059312 NGEF 25791 -2.05615 0.040766036 0.238212323 0.75323167 0.56267648 cg08235271 LPHN2 23266 2.0561 0.040771419 0.238212323 1.33319254 0.57946753 cgl7606683 HSPC138 51501 2.05544 0.040835365 0.238391531 1.33684623 0.57059298 cgl0950297 EFNB1 1947 2.0553 0.040848619 0.238391531 1.33658861 0.58708148 cgl7941312 PSF1 9837 -2.05522 0.040856742 0.238391531 0.75243539 0.57003832 cg06305312 PQLC2 54896 -2.05515 0.04086401 0.238391531 0.75526019 0.5883925 cgl4176475 TTF1 7270 2.05514 0.040864423 0.238391531 1.32447824 0.56560105 cg20169062 HSPB3 8988 -2.05491 0.040887094 0.238451046 0.75863666 0.56403792 cgl5384717 PRPF3 9129 2.0545 0.040926581 0.238571978 1.32484472 0.56434046 cgl5925792 MX1 4599 2.05436 0.040940363 0.238571978 1.31620739 0.57382009 cgl2641660 TTF2 8458 2.05431 0.040945257 0.238571978 1.33945543 0.57286204 cg06481786 RAD52B 201299 2.05406 0.040970021 0.238595296 1.3200612 0.56081081 cgl8219418 PARP6 56965 -2.05401 0.040974213 0.238595296 0.75556793 0.57714804 cgl5606663 KRTAP15-1 254950 -2.05364 0.041010481 0.238666164 0.7505318 0.5648447 cg21457147 KCTD4 386618 -2.05363 0.041011345 0.238666164 0.75228137 0.57518153 cg09989134 C12orf44 60673 2.05339 0.041035179 0.238732216 1.33192074 0.56968536 cgl l903151 LOC388152 388152 2.05326 0.041048222 0.238735469 1.32562089 0.56161759 cgl6051685 TRIM63 84676 -2.05303 0.041070544 0.238792664 0.75053577 0.57553449 cg27497900 NCSTN 23385 2.05265 0.041107345 0.238879079 1.3371532 0.57346712 cg09191232 PAPSS1 9061 2.05255 0.041117388 0.238879079 1.31683149 0.56434046 cg04527918 UCN 7349 2.05249 0.041122882 0.238879079 1.32685456 0.58894716 cg25955816 HIST3H3 8290 2.05236 0.041135877 0.238882004 1.32411224 0.57578661 cg26775866 PTTG1 9232 2.05205 0.041166633 0.238976524 1.32837598 0.5841065 cgl2939547 C6orf27 80737 -2.05194 0.041177147 0.238976524 0.76068578 0.56081081 cg06277838 SLC16A2 6567 -2.05146 0.0412243 0.239133603 0.74543586 0.56590359 cg01414934 SH3BGRL3 83442 2.05141 0.041229223 0.239133603 1.32730793 0.56055869 cgl6530429 LI 28 79727 2.05108 0.041261707 0.239249444 1.32476485 0.58098023 cg26478992 ASPN 54829 -2.05086 0.041282864 0.239274155 0.75878189 0.56731545 cg07973390 CARF 55602 2.05075 0.041293792 0.239274155 1.32596849 0.57583703 cgl6890267 CXCL2 2920 2.05065 0.041303506 0.239274155 1.3261502 0.55546591 cgl5153383 KATNB1 10300 2.05018 0.041350128 0.239422809 1.31763952 0.56333199 cgl4950072 LAMA1 284217 2.05013 0.041354207 0.239422809 1.31954583 0.54124647 cg03077836 DDEF2 8853 2.04946 0.041420378 0.239684977 1.32852683 0.56403792 cgl8432384 FU32771 220004 -2.04942 0.041424737 0.239684977 0.759684 0.56171844 cg09827833 TEK 7010 2.04924 0.041441744 0.239684977 1.34211363 0.56313029 cgl3694749 SCN4A 6329 -2.04916 0.041449625 0.239684977 0.75610201 0.57245865 cg24574111 EDG7 23566 -2.0489 0.041475314 0.239719551 0.74866083 0.56413877
cg02330106 MGMT 4255 2.04885 0.041480676 0.239719551 1.31505762 0.56091166 eg 10938446 IL1RN 3557 -2.0485 0.041515128 0.239780042 0.75601947 0.58340057 cg00876704 PKN1 5585 -2.04849 0.041516221 0.239780042 0.74979217 0.58082896 cg01930621 ZNF649 65251 2.04828 0.041536924 0.239827182 1.32975292 0.57921541 cgl l693019 A R1B10 57016 -2.04781 0.041582924 0.239918663 0.75631996 0.55783582 cg20401181 SLC30A7 148867 2.04776 0.041587978 0.239918663 1.31635389 0.5657019 cgl5901783 KCTD12 115207 2.04773 0.041591184 0.239918663 1.31641049 0.57155103 cg24101873 C20orf70 140683 -2.04761 0.041602953 0.239918663 0.75394043 0.56444131 cgl l044163 CPVL 54504 2.04736 0.041627307 0.239986738 1.32639149 0.57266035 cg05637351 CDH7 1005 2.04698 0.041665816 0.240109484 1.31889409 0.57624042 cg20360244 SLC35E3 55508 2.04682 0.041681101 0.240109484 1.32456155 0.57588746 cg08461397 SNTB2 6645 2.04663 0.04169958 0.240109484 1.32871654 0.56771884 eg 11378686 ZNF318 24149 2.04642 0.041720394 0.240109484 1.31841857 0.5637858 cg27537561 VDR 7421 2.04639 0.041724011 0.240109484 1.336376 0.58370311 cgl3325529 TMEM107 84314 2.04624 0.041738949 0.240109484 1.3171484 0.57412263 cgl9464016 PRDM1 639 2.04615 0.041747626 0.240109484 1.30999122 0.56771884 cgl7251713 SERPINB7 8710 -2.04613 0.041749047 0.240109484 0.76463058 0.5697862 cg24906992 C20orf44 55245 2.04587 0.041775452 0.240138702 1.33452269 0.57593788 cg08602689 KDELC1 79070 -2.04583 0.041779242 0.240138702 0.75836229 0.56328157 cg09617747 N0B1P 28987 2.04533 0.041828528 0.240282993 1.31583423 0.57956837 cgl4662379 KIF1A 547 -2.04523 0.041839105 0.240282993 0.75103515 0.57008875 cg23462402 FAM 113A 64773 -2.0452 0.041842041 0.240282993 0.74430522 0.56625656 cgl5691199 CEBPE 1053 2.04458 0.041903518 0.240476964 1.31037381 0.57901372 cgl2042396 MAP1D 254042 2.04449 0.041912589 0.240476964 1.33530172 0.56403792 cgl8934187 STARD6 147323 2.04444 0.041917807 0.240476964 1.32137411 0.57190399 cgl2044210 APBA2 321 -2.04435 0.04192612 0.240476964 0.7477727 0.57719847 cg04564030 CDH7 1005 2.04387 0.041974528 0.240558715 1.31962325 0.57397136 cgl8294158 ORC5L 5001 -2.04367 0.041994481 0.240558715 0.75192608 0.5770472 cg21350115 CALCRL 10203 2.04353 0.042008195 0.240558715 1.32486956 0.57568576 cg09965258 NFIB 4781 2.04338 0.04202333 0.240558715 1.33112012 0.56192013 cg09164559 KIAA1279 26128 2.04336 0.04202522 0.240558715 1.31780174 0.57866075 cg08525207 RPS7 6201 2.04333 0.04202813 0.240558715 1.32107959 0.56252521 cg05819268 CACNG1 786 -2.04321 0.042039611 0.240558715 0.7491291 0.58143405 cg21168884 C6orfl22 401288 -2.04318 0.04204255 0.240558715 0.75686017 0.56202098 cg03294491 SMAD2 4087 2.04307 0.042053589 0.240558715 1.33083342 0.55803752 cgl9855618 ZNF623 9831 -2.04135 0.042226039 0.241469893 0.75449244 0.54608713 cg23652526 HNRPUL1 11100 2.04123 0.042238133 0.241469893 1.32567145 0.56494554 cgl6139316 S100A9 6280 2.04063 0.042297871 0.24161811 1.32854903 0.55899556 cg24664861 SPAG16 79582 2.04038 0.042323068 0.24161811 1.3198908 0.55012102 cgl2639234 NAT2 10 -2.04031 0.042329475 0.24161811 0.7556282 0.58612344 cg02741744 ACTR6 64431 2.04023 0.04233766 0.24161811 1.33142297 0.57387051 cg23490074 C19orf2 8725 2.04023 0.042337886 0.24161811 1.32873578 0.56671037
eg 16204289 FU13391 84141 -2.04021 0.042339869 0.24161811 0.75665907 0.57266035 cg24489015 LPO 4025 2.04004 0.042357338 0.24164316 1.32325836 0.57977007 cg03885639 PANX3 116337 2.03986 0.042375246 0.24164316 1.31583318 0.57124849 cg01761409 RAB38 23682 2.03979 0.042382167 0.24164316 1.32013878 0.57906414 cgl2809314 ZNF445 353274 2.03962 0.042399381 0.241669247 1.31045631 0.58022388 eg 13599477 NET1 10276 2.03912 0.042449789 0.241773497 1.32717904 0.56197055 cg09080746 PTHB1 27241 2.03901 0.042460333 0.241773497 1.32057672 0.58244252 cg03000603 DHX34 9704 2.03887 0.042474221 0.241773497 1.31250164 0.55496168 cgl2177743 TTC12 54970 2.03884 0.042477292 0.241773497 1.33398293 0.56923155 cgl2435611 BRIP1 83990 2.03881 0.042480886 0.241773497 1.32425433 0.57301331 cgl l710560 KRTAP9-3 83900 -2.03824 0.042537979 0.2420264 0.75912291 0.58627471 cg01253545 RNF185 91445 2.03806 0.04255633 0.242029452 1.32567689 0.57835821 cgl9481052 PLP1 5354 -2.03797 0.042565378 0.242029452 0.76151146 0.57240823 cg03506489 KCNA4 3739 2.03783 0.042578739 0.242029452 1.32487205 0.58067769 cg02187914 ATP6V1C1 528 2.03773 0.042589141 0.242029452 1.32590794 0.56429004 cg24805239 DFNA5 1687 2.03723 0.042639493 0.242243607 1.3182977 0.56948366 cg03942271 AUH 549 2.03681 0.042681939 0.242412734 1.32311312 0.57629084 cg08046471 CXCL11 6373 -2.03654 0.042709267 0.242493822 0.75859944 0.5734167 cg24443885 ZNF227 7770 2.03641 0.042722964 0.242493822 1.32189225 0.55037313 cg22325646 RND2 8153 2.03619 0.04274429 0.242493822 1.31803346 0.54522993 cgl l916609 IL1RL1 9173 2.03617 0.04274694 0.242493822 1.34648457 0.57139976 cg09208010 MMP14 4323 2.03603 0.042761418 0.242504013 1.32090822 0.58526624 cgl2737801 TCEA1 6917 2.0358 0.042784013 0.242560222 1.31683657 0.56933239 cgl6678925 OR1A2 26189 -2.03558 0.042806488 0.242560829 0.75559851 0.5725595 cg01639256 FU25084 151516 -2.03555 0.042809489 0.242560829 0.743395 0.56605486 cg27012203 MTHFR 4524 -2.035 0.042865149 0.242684347 0.7567382 0.56802138 cg23699324 CTNNA2 1496 2.03483 0.042882006 0.242684347 1.30847722 0.56660952 cg07817783 DAP 1611 2.03466 0.042899414 0.242684347 1.3169295 0.57674466 cg09191626 SPON1 10418 2.03446 0.042919647 0.242684347 1.31500425 0.57412263 cg20545295 GOLGB1 2804 2.03443 0.042922814 0.242684347 1.31837207 0.58087939 cgl0129493 CD33 945 2.03434 0.042932043 0.242684347 1.31925455 0.57492941 cg24711626 KIAA1012 22878 2.03408 0.042959118 0.242684347 1.30488991 0.55526422 cgl5422784 LRRC8B 23507 -2.03397 0.042969682 0.242684347 0.75128358 0.56817265 cgl l251086 DUSP11 8446 2.03376 0.042991063 0.242684347 1.32435176 0.56575232 cg27087525 FAM8A1 51439 2.03364 0.043003711 0.242684347 1.32103805 0.56302945 cgl l387519 MRPL53 116540 2.03344 0.043023688 0.242684347 1.33258287 0.5592981 cg20377955 SP8 221833 2.03342 0.043025849 0.242684347 1.31745253 0.57018959 cgl4212314 HSPD1 3329 2.03335 0.043033296 0.242684347 1.30739486 0.57054256 cgl4558138 ANKRD1 27063 -2.03321 0.043047528 0.242684347 0.75485229 0.544524 cg01801174 UFC1 51506 2.0332 0.043047826 0.242684347 1.32961667 0.58128278 cgl8263686 LOC128153 128153 2.03317 0.043050743 0.242684347 1.31605634 0.57402178 cg03160309 PTGS2 5743 2.03311 0.043057157 0.242684347 1.33788452 0.56000403
cg24794734 AGL 178 2.03305 0.043063807 0.242684347 1.32170186 0.58945139 cgl7048363 CDK8 1024 2.03287 0.043081299 0.242684347 1.31065277 0.56691206 cgl5032239 CYFIP1 23191 2.03284 0.043085104 0.242684347 1.31746709 0.57417305 eg 11764747 EFNB1 1947 -2.03219 0.043151099 0.242925693 0.75653826 0.55445744 cg02475653 KIAA0703 9914 -2.03206 0.043164376 0.242925693 0.75823191 0.56802138 cgl8581221 FU45645 375287 2.03204 0.043166061 0.242925693 1.31880902 0.55087737 cgl3462129 DLX5 1749 2.03187 0.043183576 0.242935363 1.32041902 0.58037515 cg01668126 MSR1 4481 -2.03174 0.043196742 0.242935363 0.75272794 0.56176886 cg22012054 ATP5B 506 2.03165 0.043205891 0.242935363 1.30966093 0.56081081 cg26045205 Clorfl79 338094 -2.03114 0.043258515 0.243159756 0.75882559 0.55788624 cg02717866 FU32771 220004 -2.03093 0.04327926 0.243204876 0.74799739 0.55319685 cg01796228 LIFR 3977 -2.03072 0.043301364 0.243257605 0.76111029 0.56393707 cg01228636 PTEN 5728 2.03052 0.043321016 0.243286152 1.30560001 0.57553449 cg07393322 A4GALT 53947 2.03042 0.04333189 0.243286152 1.30783507 0.5541549 cg21311175 HIRA 7290 2.03029 0.043345354 0.243290317 1.32215135 0.56479427 cg05815893 C17orf80 55028 2.02949 0.043427401 0.24367931 1.31416251 0.57013917 cg09523691 ATG12 9140 2.02926 0.043450712 0.243724533 1.32153144 0.58007261 cgl2648583 FBX08 26269 2.02905 0.043471956 0.243724533 1.33842683 0.56605486 cgl0615091 FAM 13C1 220965 2.02903 0.043473696 0.243724533 1.31652659 0.56761799 cg06776256 GPRC5A 9052 2.02873 0.043504763 0.243827222 1.30023066 0.55793667 cg27638713 MCM3 4172 2.02856 0.043522679 0.243855434 1.31096675 0.57225696 cg05844583 SLC19A3 80704 2.02843 0.043535301 0.243855434 1.32638607 0.56323114 cgl6959972 DMC1 11144 2.0281 0.043569995 0.243950889 1.32971846 0.56010488 cg01316071 C14orfl39 79686 -2.02779 0.043601155 0.243950889 0.75430293 0.57528237 cgl9526626 ZNF491 126069 2.02779 0.043601342 0.243950889 1.3173594 0.5436668 cg27221338 KDELR2 11014 -2.02777 0.043603371 0.243950889 0.75245216 0.57003832 cg06956273 GNAT2 2780 -2.02712 0.043670037 0.244030027 0.7509879 0.55425575 cg07611925 KCNE2 9992 -2.02705 0.043677338 0.244030027 0.7482482 0.56696249 cg05429895 TLR4 7099 2.02683 0.043700235 0.244030027 1.32601772 0.58254336 cg04126335 ITGA10 8515 -2.0267 0.043713494 0.244030027 0.75446923 0.56161759 cg l7038116 ASH1L 55870 2.02651 0.043733607 0.244030027 1.32874738 0.56590359 cg22527415 LSM 16 80153 2.02635 0.043749525 0.244030027 1.32447138 0.55718032 cg24532476 CHFR 55743 -2.02627 0.043757878 0.244030027 0.75499365 0.55233965 cgl2774845 ENTPD5 957 2.02619 0.043765964 0.244030027 1.31178335 0.55425575 cg22899145 0PN1LW 5956 -2.02607 0.043778535 0.244030027 0.75887032 0.5507261 eg 18674980 CA3 761 2.02606 0.043779673 0.244030027 1.32824713 0.56933239 cgl4986136 WBP5 51186 2.02604 0.043781334 0.244030027 1.31851738 0.56257564 cg03608577 OR12D3 81797 -2.02604 0.043781829 0.244030027 0.75581211 0.5751311 cgl4236389 FU33860 284756 2.02602 0.04378341 0.244030027 1.31195844 0.55042356 cg03862760 MGC10911 84262 -2.02556 0.043831498 0.244226864 0.75041164 0.56761799 cg00301864 RAB35 11021 -2.02506 0.043882624 0.244300727 0.75812073 0.55465914 cg26533949 DZIP1L 199221 2.02505 0.043884141 0.244300727 1.31612199 0.5639875
cg22189519 CDC37L1 55664 -2.02499 0.043889948 0.244300727 0.75807288 0.56625656 cgl7610929 ACCN4 55515 2.02494 0.043895855 0.244300727 1.33464119 0.56212182 eg 14043602 OR1E1 8387 -2.0247 0.043919824 0.244363006 0.75709865 0.56297902 cg26228569 CRSP8 9442 2.02429 0.043962545 0.244457133 1.32168306 0.57376967 cgl4695751 ALS2CR7 65061 -2.02422 0.043969543 0.244457133 0.75295111 0.56146632 cgl5167433 XRCC1 7515 2.02417 0.043975092 0.244457133 1.3227715 0.5639875 cg23504707 PPM 1A 5494 -2.02399 0.043993523 0.244480842 0.75671862 0.56565147 cg22772878 DIRAS1 148252 2.02337 0.044057676 0.244480842 1.30844908 0.58501412 cg21667836 PRMT8 56341 2.0233 0.044065824 0.244480842 1.3146626 0.56358411 cg26399035 THUMPDl 55623 2.02328 0.04406795 0.244480842 1.31594699 0.55324728 cgl8611122 LASS2 29956 2.02317 0.044079136 0.244480842 1.31974221 0.59590561 cg06516650 RAB30 27314 2.02315 0.044081238 0.244480842 1.30695855 0.56166801 cg02409351 CART1 8092 2.02289 0.044108119 0.244480842 1.32913943 0.56792053 cg00514407 SERPINE2 5270 2.02272 0.044125559 0.244480842 1.32240932 0.59403994 cg06154597 MGC4618 84286 -2.02257 0.044140968 0.244480842 0.76240253 0.55612142 cgl4371329 GNAL 2774 -2.02243 0.044155482 0.244480842 0.74856762 0.57034086 cgl6235034 FRMPD1 22844 -2.0224 0.044158666 0.244480842 0.76163443 0.58849334 eg 16462075 MUC3B 57876 -2.02238 0.044160798 0.244480842 0.75234394 0.59454417 cg04021421 FANCC 2176 -2.02217 0.044182504 0.244480842 0.75340749 0.56943324 cg04826883 CA12 771 2.02214 0.04418549 0.244480842 1.32001341 0.56887858 eg 18986964 ABL1 25 2.02179 0.044221848 0.244480842 1.32394359 0.57225696 cg03887534 BCL2L13 23786 2.02178 0.044223522 0.244480842 1.32014676 0.56776926 cg24959428 GBP6 163351 -2.02174 0.044227071 0.244480842 0.7575258 0.54931424 eg 11564670 MC2R 4158 -2.02155 0.044247085 0.244480842 0.74816232 0.56973578 cgl5277108 SDS 10993 -2.02155 0.044247615 0.244480842 0.7575294 0.55712989 cg06765947 UROC1 131669 -2.02149 0.044253567 0.244480842 0.76523436 0.56015531 cg22802439 UPK1A 11045 -2.02132 0.044271098 0.244480842 0.75089674 0.57139976 cg03574115 WDR65 149465 -2.02128 0.044275483 0.244480842 0.76192948 0.55233965 cg23096644 PEG10 23089 2.02117 0.044286824 0.244480842 1.32451084 0.5699879 cg03943081 TCERG1L 256536 -2.02111 0.0442927 0.244480842 0.76461687 0.54084308 cg00808492 REG4 83998 -2.02096 0.044308365 0.244480842 0.75885342 0.55960065 cg07577263 NUP205 23165 2.02085 0.044320756 0.244480842 1.31658356 0.56252521 cg22084336 UBP1 7342 2.02079 0.044326133 0.244480842 1.31769199 0.57074425 cg00882832 SPRY1 10252 2.02058 0.044348329 0.244480842 1.32597691 0.57644211 cgl4723014 ZMYM5 9205 2.02035 0.044371919 0.244480842 1.31692471 0.55914683 cg00472814 ADAMTSl 9510 2.02025 0.044382992 0.244480842 1.33159588 0.57795482 cgl2104707 ZNF426 79088 2.02019 0.044388653 0.244480842 1.33419692 0.57785397 cg00231920 VPS 16 64601 2.02012 0.044396322 0.244480842 1.30573336 0.5462384 cg00309204 C17orf61 254863 2.02007 0.044401252 0.244480842 1.31446143 0.57094595 cg26640549 RAD18 56852 2.01939 0.044472481 0.244802556 1.32476675 0.57195442 cgl5876417 ABCD2 225 2.01917 0.044496091 0.24484154 1.30894733 0.57167709 cgl0971269 TMEM106B 54664 2.01901 0.044512162 0.24484154 1.31497308 0.58556878
cg06418219 SHC1 6464 2.01876 0.04453909 0.24484154 1.32068863 0.56812223 cg05001145 ELL2 22936 -2.01869 0.044546257 0.24484154 0.7594449 0.57719847 cgl3954292 ZFR 51663 -2.01863 0.044552046 0.24484154 0.7606388 0.56267648 cg01299496 NOLA3 55505 2.01859 0.044556385 0.24484154 1.32753228 0.56575232 eg 15491567 DYSF 8291 2.01821 0.044596097 0.244985623 1.31603223 0.56368495 cg24214470 SERPINFl 5176 -2.0181 0.044608227 0.244985623 0.76080945 0.56862646 eg 11909865 LOC120379 120379 2.01787 0.044631751 0.245021438 1.33134442 0.56918112 cgl2676081 RIOK2 55781 2.01779 0.044640374 0.245021438 1.32286693 0.56388665 cg05714729 GALNT1 2589 2.01736 0.044685247 0.245116767 1.32838772 0.56973578 cg07136254 HFE2 148738 -2.01727 0.044695205 0.245116767 0.75575888 0.58284591 cg21754343 LCE2B 26239 -2.01716 0.044706484 0.245116767 0.75439554 0.55965107 cg00792687 C8orf41 80185 2.01708 0.044714662 0.245116767 1.30696475 0.55874345 cgl l005826 IGF2AS 51214 2.01701 0.044721832 0.245116767 1.32606379 0.58869504 cgl5836722 IL1B 3553 2.01623 0.044804354 0.245447999 1.32025875 0.54765026 cgl8450227 MAPK4 5596 -2.01611 0.044817355 0.245447999 0.75000522 0.53892699 cg07873128 OSBPL5 114879 -2.01607 0.044820772 0.245447999 0.7637744 0.59030859 cg06123346 ATP4A 495 -2.01582 0.044847053 0.245457587 0.75838349 0.56948366 cgl7489752 BAT1 7919 2.01581 0.044848194 0.245457587 1.30729785 0.56282775 cgl0215884 MGC33214 153396 2.01515 0.044917862 0.245659621 1.30542486 0.56060912 cgl4893161 FU32569 148811 -2.01506 0.044928071 0.245659621 0.76281747 0.54563332 cgl3735974 NFYC 4802 2.01503 0.044930681 0.245659621 1.32300589 0.54765026 eg 16979445 NRM 11270 -2.01498 0.044936494 0.245659621 0.76329738 0.57397136 cg02307482 C12orf60 144608 2.01483 0.044951401 0.245670883 1.32310884 0.56792053 cgl5373285 MEG3 55384 -2.01463 0.044972849 0.245677242 0.75481443 0.55995361 cgl8878034 C6orfl08 10591 2.01448 0.044988815 0.245677242 1.31313891 0.55702904 cgl0158181 GRK4 2868 2.01446 0.044991106 0.245677242 1.3102899 0.56287818 cg22692158 PRB4 5545 -2.0142 0.045017913 0.245684854 0.75539199 0.57099637 cgl9118077 A R1C3 8644 2.0142 0.045018195 0.245684854 1.33025235 0.56025615 cg21169285 MAPK9 5601 -2.0139 0.045050365 0.245744353 0.75720289 0.56055869 cgl7256555 C8orf53 84294 2.01374 0.045066845 0.245744353 1.31895465 0.57336628 eg 19346899 MGC24665 116028 2.01373 0.04506765 0.245744353 1.31875027 0.57755143 cgl6473288 OR1N1 138883 -2.01344 0.045098309 0.245822919 0.75630933 0.55813836 cg21325760 MAGEL2 54551 -2.01318 0.045126378 0.245822919 0.75774468 0.53721259 cgl ll77450 SENP5 205564 2.01315 0.045129447 0.245822919 1.31678942 0.57528237 cgl8982568 KRT1B 374454 -2.01304 0.045141561 0.245822919 0.75915423 0.55697862 cgl4285013 MYBL1 4603 2.01291 0.045154446 0.245822919 1.3418558 0.57281162 cgl3916322 HRASLS3 11145 2.01261 0.045186796 0.245822919 1.31033256 0.58324929 cgl3755070 FLU 2313 2.0126 0.045187642 0.245822919 1.3222002 0.55304558 cg02992632 FGF12 2257 2.01254 0.045193928 0.245822919 1.31632386 0.55667608 cg08093211 CSTF2 1478 2.01248 0.045200236 0.245822919 1.31515006 0.56030658 cg04106641 ORC4L 5000 2.01238 0.045210607 0.245822919 1.33732028 0.57901372 eg 16986494 FHIT 2272 2.01206 0.045245158 0.245875566 1.31309862 0.55546591
cgl7741291 DDX21 9188 2.01203 0.045248284 0.245875566 1.32043922 0.57069383 cgl8128666 NCOA1 8648 -2.01193 0.045258863 0.245875566 0.76129446 0.5736184 cg09725013 GTF3C1 2975 2.01172 0.045281583 0.245896716 1.30984036 0.57351755 cg24854010 WNT5B 81029 -2.01146 0.045308758 0.245896716 0.76011896 0.57024002 cg01803238 BCL2 596 2.01137 0.045318292 0.245896716 1.32782498 0.58748487 cgl3338132 FAM71C 196472 -2.01126 0.045330281 0.245896716 0.75193257 0.58814038 cgl8168989 C9orf41 138199 -2.0112 0.04533599 0.245896716 0.75062917 0.55783582 cgl7471102 FUT3 2525 2.01112 0.045345393 0.245896716 1.31079181 0.5744756 cgl6817034 GMEB1 10691 2.01085 0.045373189 0.245896716 1.31680405 0.55561718 cg03580351 FU40869 348654 2.01084 0.045374959 0.245896716 1.31403125 0.54991932 cgl2320676 E2F6 1876 2.01078 0.045381103 0.245896716 1.3103399 0.55828963 cgl9128498 FBXL5 26234 2.01057 0.045403895 0.245896716 1.31538805 0.57664381 cg00479269 C2orf29 55571 2.0105 0.045411107 0.245896716 1.32645341 0.57094595 cg02902770 RARRES2 5919 -2.01044 0.045417094 0.245896716 0.75191713 0.57482856 cg27043873 CDH18 1016 -2.01032 0.045429919 0.245896716 0.7548652 0.56020573 cgl3150596 GIPCl 10755 2.00942 0.04552642 0.246170693 1.31184468 0.56534893 cgl6208491 PRPF4B 8899 2.00941 0.045527093 0.246170693 1.30457054 0.57619 cgl7306637 CLDN20 49861 -2.00929 0.045539946 0.246170693 0.76251502 0.56161759 cg07671949 ESR1 2099 2.00918 0.045551125 0.246170693 1.32855487 0.56746672 cg01962969 CBR1 873 2.00911 0.045558945 0.246170693 1.313918 0.56010488 cg03874199 HOXD12 3238 2.00907 0.045563199 0.246170693 1.32558478 0.57190399 cg04624659 SPAG17 200162 2.009 0.045570648 0.246170693 1.32531656 0.55707947 cg23973566 C6orf32 9750 -2.00881 0.045591204 0.246212184 0.75594322 0.5813332 cg25993152 XAGE5 170627 -2.00867 0.045606211 0.246223691 0.7484677 0.56040742 cgl9002579 SMPX 23676 -2.00846 0.045628016 0.246242087 0.75683258 0.55899556 eg 18047970 GADL1 339896 -2.00823 0.045652794 0.246242087 0.76137952 0.57240823 cg24123124 MRPS17 51373 2.0082 0.045656793 0.246242087 1.32024267 0.56731545 cg23707493 TNKS2 80351 2.00815 0.045661126 0.246242087 1.31823571 0.54477612 cg09881917 FUK 197258 2.00718 0.045765436 0.246665869 1.31832494 0.56166801 cg05799317 C6orfll8 168090 -2.00711 0.045772819 0.246665869 0.75934081 0.57069383 cg02285477 MGC9850 219404 -2.00706 0.045778405 0.246665869 0.76305638 0.57644211 cg09061733 SERPINGl 710 -2.00656 0.045832068 0.246885455 0.74773558 0.56524808 cg08504905 LENG1 79165 2.00635 0.045854411 0.246918272 1.31003627 0.56781969 cg26402828 PCK2 5106 2.00626 0.045863985 0.246918272 1.30243944 0.55168415 cgl2374721 PRAC 84366 2.00575 0.045919048 0.247021807 1.31467181 0.57644211 cg01936555 SLC17A2 10246 -2.00571 0.04592293 0.247021807 0.74810524 0.57992134 cg09209002 SAS10 57050 2.0056 0.045934582 0.247021807 1.3184187 0.5849637 cg04007936 CARHSP1 23589 -2.0056 0.045934886 0.247021807 0.7574744 0.57644211 cg02875404 VN1R1 57191 -2.00523 0.04597453 0.247127721 0.7571257 0.58148447 cg03025569 TRIM 16 10626 2.00518 0.045980428 0.247127721 1.30844613 0.58879589 cg05754631 GAB1 2549 2.00483 0.046017555 0.247247996 1.31566508 0.56020573 cgl6852892 MMP16 4325 2.00472 0.046030237 0.247247996 1.31501825 0.57805567
cg21194776 USP54 159195 -2.00461 0.046041594 0.247247996 0.75231639 0.55445744 cg02868123 REGL 5969 2 .00432 0.04607251 0.247344556 1.32319354 0.55960065 cg05517572 STAP2 55620 -2 .00403 0.046103787 0.247398607 0.76286513 0.58022388 cg08810779 DHX16 8449 2 .00392 0.046115448 0.247398607 1.3108192 0.56595401 cg00967316 PPP1R3A 5506 -2 .00381 0.046127871 0.247398607 0.76473311 0.54775111 cg24211388 AIF1 199 2 .00369 0.046141208 0.247398607 1.31576839 0.5770472 cgl3589108 FAM5B 57795 2 .00363 0.046147264 0.247398607 1.31292451 0.56993748 cg26218269 MAB21L2 10586 -2 .00328 0.04618536 0.247512672 0.76477241 0.55143203 cg21032203 ZNF265 9406 2 .00319 0.046194427 0.247512672 1.31975615 0.57220654 cg07550278 C10orf4 118924 2.003 0.046215324 0.247555277 1.32212125 0.56524808 cgl4341030 C12orf60 144608 2 .00283 0.046233189 0.247581623 1.32642697 0.5742739 cg24975564 PDE3A 5139 2 .00255 0.04626379 0.247624027 1.3133337 0.56050827 cg01671881 C20orf71 128861 -2 .00244 0.046275385 0.247624027 0.76021989 0.55924768 cg26770882 AIPL1 23746 2 .00225 0.046296064 0.247624027 1.30981545 0.55939895 cg00399483 DCC 1630 -2 .00224 0.04629775 0.247624027 0.76112319 0.56620613 eg 18604842 FU36046 164592 2 .00199 0.046324994 0.247624027 1.32047084 0.56423961 cg01875775 CHEK2 11200 -2 .00182 0.046343398 0.247624027 0.76177958 0.57134933 cg22289115 MUCDHL 53841 -2 .00177 0.046348432 0.247624027 0.7662319 0.57992134 cg25167447 NAV1 89796 -2 .00156 0.046371197 0.247624027 0.76404048 0.57286204 cgl3921319 PTMA 5757 -2 .00139 0.04638981 0.247624027 0.75247003 0.58138362 cg25836326 DRD3 1814 2 .00136 0.046392535 0.247624027 1.32679823 0.57482856 cg24949344 PLEKHA9 51054 2 .00135 0.046394256 0.247624027 1.32562039 0.57795482 cgl5756091 RGSL2 84227 -2 .00114 0.046416156 0.247624027 0.75558749 0.57694635 cgl3683440 MGC39662 131831 2 .00104 0.046427401 0.247624027 1.30806174 0.57432432 cgl0883621 MGC16372 92749 2 .00099 0.046433416 0.247624027 1.31195959 0.57896329 cgl4727512 TSSK2 23617 2 .00094 0.046438399 0.247624027 1.31846611 0.56988705 cgl ll58374 TFF2 7032 -2 .00085 0.046448293 0.247624027 0.76183409 0.56544978 cg00524288 UPP1 7378 2 .00061 0.046473837 0.24769009 1.32315841 0.57175272 cg22721827 NTN2L 4917 2 .00048 0.046488153 0.24769009 1.30001139 0.57134933 cg03135127 TRMT1 55621 2 .00034 0.046503217 0.24769009 1.30113335 0.57724889 cg06323290 HK1 3098 -2 .00012 0.046527209 0.24769009 0.7453388 0.57336628 cgl5751406 ZNF558 148156 -2 .00007 0.046533178 0.24769009 0.75939775 0.55077652 cg09286787 LOC284361 284361 -1 .99995 0.046546096 0.24769009 0.7509202 0.56691206 cg04036714 NAPE-PLD 222236 1.9999 0.046551352 0.24769009 1.32045467 0.55798709 cg08526867 COX7C 1350 1.99907 0.046641681 0.247876882 1.30866275 0.56015531 cgl8277508 SLC39A8 64116 1.99903 0.046645909 0.247876882 1.32065245 0.56973578 cg03821311 HIST1H1B 3009 -1.999 0.046649423 0.247876882 0.75500283 0.5567265 cg04359302 MRPL47 57129 -1.99889 0.046661644 0.247876882 0.76220703 0.55909641 cg07940485 SLC16A10 117247 1.99887 0.046663534 0.247876882 1.3155397 0.59560307 cg20227165 PRDM11 56981 -1.99886 0.046664232 0.247876882 0.7645558 0.56630698 cgl l801374 C20orfl60 140706 -1.99872 0.046680217 0.247882253 0.76002786 0.57850948 cg20377762 TMEM61 199964 -1.99862 0.046691168 0.247882253 0.76408358 0.55763413
cgl6821394 NDFIP1 80762 -1.9982 0.046736345 0.24805323 0.76451628 0.56514724 cg04229238 RB1CC1 9821 1.99753 0.046809559 0.248372879 1.32364815 0.54971763 cg00331433 SYAP1 94056 1.99708 0.046858986 0.248463595 1.31456688 0.56272691 cg06810647 CRAMPIL 57585 1.99695 0.046873033 0.248463595 1.29788678 0.55218838 cg03916787 RPL35 11224 1.99684 0.046884657 0.248463595 1.31596024 0.56358411 cg21257635 SYF2 25949 1.99675 0.046894509 0.248463595 1.31920935 0.56590359 cgl9206150 SNF8 11267 1.99666 0.046904592 0.248463595 1.31095314 0.56323114 cg06963844 FBX06 26270 1.99666 0.046904614 0.248463595 1.3079909 0.56822307 cg06313930 MAGEA5 4104 -1.99597 0.046979695 0.248599324 0.76673014 0.5584409 cg27592318 HEMGN 55363 -1.99586 0.046992734 0.248599324 0.75303528 0.5620714 cgl9135982 SKP2 6502 1.99577 0.047002366 0.248599324 1.32510702 0.55753328 cg22766145 BHLHB5 27319 1.99571 0.047008795 0.248599324 1.30823747 0.55455829 cg02192855 HIST1H2BI 8346 1.9955 0.047031776 0.248599324 1.32032591 0.55067568 cg07710481 SLITRK5 26050 1.99548 0.047034384 0.248599324 1.31524147 0.58375353 cg00736326 ARPC1A 10552 1.99534 0.047049512 0.248599324 1.32958708 0.59035902 cg04282622 FAM71C 196472 -1.99528 0.047055509 0.248599324 0.76663511 0.5567265 cgl8014844 PARS 2 25973 -1.99527 0.047056958 0.248599324 0.763548 0.56101251 cg22117143 MPDZ 8777 -1.99524 0.047060237 0.248599324 0.76469895 0.56751714 cgl7164520 CGB1 114335 1.99491 0.04709633 0.248654957 1.316672 0.55879387 cg04282422 PAG El 8712 -1.99491 0.047096775 0.248654957 0.75485194 0.57654296 cgl2871124 STARD4 134429 1.99445 0.047147366 0.248853356 1.30037002 0.55627269 cg21504918 GPX3 2878 1.99391 0.047206053 0.249094366 1.30883971 0.55546591 cg23746359 FAM 19A3 284467 -1.99318 0.047286801 0.249326915 0.76633211 0.57069383 cg03943509 PYGM 5837 -1.9931 0.047295957 0.249326915 0.76444315 0.57311416 cg03875678 GZMB 3002 1.99308 0.047297258 0.249326915 1.31011408 0.54896128 cgl0850119 FBX04 26272 1.993 0.047307109 0.249326915 1.3109799 0.57699677 cg09971646 DLK1 8788 -1.9929 0.047317539 0.249326915 0.76093132 0.57709762 cgl2438034 MAGEF1 64110 1.99276 0.047333262 0.249326915 1.31407368 0.58229125 cg06645778 HSPC159 29094 1.99268 0.047341391 0.249326915 1.31836439 0.55733159 cg03697316 LZTR1 8216 1.99251 0.047360367 0.249358183 1.30300117 0.56423961 cg21224759 PIN4 5303 -1.99223 0.047392081 0.249436918 0.76510869 0.56388665 cg05127924 FBXW10 10517 -1.99207 0.047409406 0.249436918 0.76144486 0.55970149 cgl8396533 DYDC1 143241 -1.99193 0.047424585 0.249436918 0.76671357 0.55697862 cg23282674 IL20 50604 -1.99147 0.047475359 0.249436918 0.76616349 0.56610528 cgl3849825 CCNB1 891 -1.99143 0.047479581 0.249436918 0.76449975 0.56620613 cg01182697 TMEM59 9528 1.99099 0.047528201 0.249436918 1.32580805 0.57412263 cg02797569 PCOLCE 5118 -1.99096 0.047532345 0.249436918 0.75756061 0.57442517 cg00598858 PRKCSH 5589 1.99088 0.047540993 0.249436918 1.31097478 0.55163372 cg23514672 FU32871 146279 -1.99057 0.047575417 0.249436918 0.757703 0.57225696 cg09475757 NEIL3 55247 1.99054 0.04757859 0.249436918 1.31803116 0.57669423 eg 11939496 CD244 51744 1.99052 0.047580343 0.249436918 1.30823175 0.5665591 cg07979752 CUL5 8065 1.99051 0.04758189 0.249436918 1.3158011 0.55576846
cg00819696 TIMELESS 8914 1.98964 0..047677883 0.249436918 1.31228807 0.57175272 cg21713257 ETFDH 2110 1.9895 0. .047693683 0.249436918 1.31312592 0.54326341 cg21430666 HIST3H3 8290 1.98945 0. .047698862 0.249436918 1.31974395 0.55193627 cg08376864 HRASLS 57110 1.98944 0. .047700302 0.249436918 1.3197165 0.56953409 cg03841029 MBD1 4152 1.98903 0. .047746377 0.249436918 1.32214945 0.56726503 cgl0184886 PLA2G6 8398 1.98894 0. .047755892 0.249436918 1.30824162 0.56610528 cg06742978 ACCN2 41 -1.98876 0. .047775594 0.249436918 0.76346476 0.55339855 cg01428678 GPHN 10243 1.98866 0. .047786611 0.249436918 1.31482494 0.56928197 cg07478208 MEIS3 56917 1.98866 0. .047787325 0.249436918 1.31242905 0.55834006 cgl8561362 C1QTNF4 114900 -1.98861 0. .047792213 0.249436918 0.76018821 0.57134933 cg21604615 SYTL1 84958 1.98852 0. .047802233 0.249436918 1.31861549 0.57286204 cg03873930 ARFRP1 10139 -1.98849 0. .047805474 0.249436918 0.7571731 0.55697862 cgl8587973 CDADC1 81602 1.98842 0. .047814049 0.249436918 1.31053459 0.56358411 cg04237663 KCNV1 27012 1.98839 0. .047816966 0.249436918 1.30825526 0.58481242 cg25368212 SSX1 6756 -1.98826 0. .047831027 0.249436918 0.76464523 0.56126462 cgl0861751 RGS1 5996 1.98824 0. .047833761 0.249436918 1.3264015 0.57155103 cg07181881 KLHL23 151230 1.98817 0. .047841383 0.249436918 1.30406442 0.56252521 cgl l473104 NUDT15 55270 1.98806 0. .047853267 0.249436918 1.31232185 0.56620613 cgl5703690 IL6 3569 1.98804 0. .047856388 0.249436918 1.32969883 0.5699879 cg09600520 CDYL 9425 -1.988 0. .047860573 0.249436918 0.76083777 0.57714804 cg24448231 ZNFX1 57169 1.98792 0. .047869066 0.249436918 1.32270363 0.56408834 cgl9393233 ERV3 2086 -1.9878 0. .047882707 0.249436918 0.75010553 0.56817265 cg21111868 EGR4 1961 1.98779 0. .047884102 0.249436918 1.31069549 0.57109722 cgl7729667 KIAA0980 22981 1.98778 0. .047884373 0.249436918 1.31121161 0.56716418 cg01404615 DKK2 27123 1.98775 0. .047888762 0.249436918 1.30708393 0.58612344 cgl l373746 ALDH9A1 223 1.98773 0. .047890491 0.249436918 1.31179747 0.56756757 cgl2547930 WFDC6 140870 -1.98773 0. .047890942 0.249436918 0.76217342 0.56353368 cg25172835 PUNC 9543 -1.98767 0. .047897076 0.249436918 0.75899555 0.57467729 cg26062370 MGC18079 146395 1.98724 0. .047945489 0.249621063 1.32296372 0.57921541 cg01770400 SERPINCl 462 -1.9868 0. .047993754 0.249804336 0.76035527 0.56751714 cg06777581 RNF8 9025 1.98667 0. .048008962 0.249815496 1.31867754 0.58602259 cg22153873 BCL11A 53335 1.98654 0. .048023521 0.249816266 1.29555036 0.56746672 cgl9157971 RABIF 5877 1.98634 0. .048045585 0.249816266 1.31203879 0.57145018 cgl8129786 ZNF445 353274 -1.98631 0. .048048301 0.249816266 0.74995846 0.56802138 cgl0833014 HSP90AA1 3320 -1.98606 0. .048076322 0.249870961 0.76719295 0.56504639 cg21596858 DCST2 127579 -1.98595 0. .048088749 0.249870961 0.75490217 0.56333199 cgl3652556 SEPX1 51734 1.98587 0. .048098021 0.249870961 1.31971234 0.55551634 cgl l593656 C0MMD6 170622 1.98568 0. .048118682 0.249910408 1.31417807 0.57492941 cg01065920 NDUFA12 55967 1.98521 0. .048171763 0.249993651 1.30594724 0.57492941 cg06488678 TMPRSS9 360200 -1.98516 0. .048177451 0.249993651 0.76252497 0.55985276 cg08493463 ENPP6 133121 1.98509 0. .048185185 0.249993651 1.30647503 0.57558491 cgl6777839 PHPT1 29085 1.98507 0. .048187002 0.249993651 1.30797054 0.57654296
cg24997562 OASL 8638 1.98468 0.048231444 0.250150201 1.31590549 0.57916499 cgl8632102 CNOT8 9337 1.98457 0.04824334 0.250150201 1.29740355 0.55541549 cg01934797 GLIS2 84662 -1.98441 0.048261528 0.250176676 0.76466141 0.55259177 cg21480743 PTE 5728 1.98397 0.048311277 0.25029086 1.30321999 0.56933239 cg06590610 ZNFNIAI 10320 -1.98383 0.048326 0.25029086 0.76183151 0.60084712 cgl4030083 CDR2L 30850 1.98377 0.048332889 0.25029086 1.3106694 0.56701291 cgl6886259 CYSLTR2 57105 -1.98363 0.048348632 0.25029086 0.76141651 0.58350141 cg01471384 DKK2 27123 1.98363 0.048348998 0.25029086 1.30622614 0.58783784 cg22315542 MLR1 254251 1.98347 0.048367239 0.250317527 1.32550421 0.57775313 cg00069261 CDR2 1039 1.9832 0.048397206 0.250404848 1.31522474 0.5657019 cgl l323230 AMFR 267 -1.98295 0.048425544 0.250425536 0.75043366 0.55748286 cg21643860 RBM21 64852 1.98293 0.048427396 0.250425536 1.30889642 0.56681121 cg27015931 MGC50721 255762 1.98269 0.048454038 0.250468282 1.29973406 0.57497983 cgl5269875 H19 283120 -1.98259 0.048465641 0.250468282 0.76375955 0.54865873 cg00415978 SYNP02 171024 1.98251 0.048474956 0.250468282 1.32037942 0.56600444 cgl l500797 DLX5 1749 1.98222 0.04850692 0.250565741 1.32095746 0.57139976 cg01657380 NPFF 8620 -1.98181 0.048553587 0.250739068 0.75970427 0.5594998 cg08519905 CD9 928 1.98156 0.048581449 0.250788303 1.31386968 0.55294474 cg08062469 SPAG5 10615 1.98138 0.048601938 0.250788303 1.30418954 0.56706333 cgl8645952 PLGLB2 5342 -1.98126 0.048615099 0.250788303 0.75507954 0.55904599 cg00433406 FU32784 127731 -1.98116 0.048626488 0.250788303 0.76562662 0.55859217 cg27056145 ATG7 10533 -1.98114 0.048628693 0.250788303 0.76104013 0.5680718 cgl l313124 WIG1 64393 1.98073 0.048675006 0.250952721 1.30243255 0.57321501 cg21787206 PSMD9 5715 1.98053 0.048697929 0.250952721 1.30654439 0.57503025 cg25957124 DNAH3 55567 1.98051 0.048699944 0.250952721 1.30277061 0.5796188 cg22796458 UBQLN4 56893 -1.98027 0.048726887 0.251023914 0.75844823 0.5655002 cg09722397 GRIN2C 2905 1.98013 0.04874305 0.251039554 1.30924242 0.56580274 cg22854546 WDR33 55339 1.97971 0.048790825 0.251168702 1.30522436 0.55097822 cgl0124201 BOLL 66037 -1.97968 0.048794395 0.251168702 0.76823742 0.58067769 cg04444771 ClOorflO 11067 1.9795 0.048814577 0.251197865 1.31527526 0.56444131 cgl5210999 DTNBP1 84062 -1.97929 0.048838635 0.251197865 0.77171197 0.5532977 cg25996835 BBS4 585 1.97926 0.048841459 0.251197865 1.31100555 0.57992134 cg21615171 SLC22A13 9390 -1.97909 0.04886042 0.251197865 0.75937625 0.56600444 cg27207274 MYC 4609 1.97905 0.04886574 0.251197865 1.30001285 0.57412263 cg25103286 NT5DC2 64943 -1.97883 0.048889953 0.251254789 0.76364015 0.56605486 cg08935243 CETN3 1070 1.97864 0.048912261 0.251301902 1.29558157 0.57346712 cg02284188 TRIM49 57093 -1.978 0.048984969 0.251515218 0.7596552 0.55420533 cg22721186 ATAD2 29028 -1.97785 0.049001321 0.251515218 0.76045156 0.56242437 cg09390792 TSPAN18 90139 -1.97764 0.049025048 0.251515218 0.74900883 0.56181928 cg07607462 UBR1 197131 1.97763 0.049026505 0.251515218 1.30883814 0.57729931 cg25802424 IRS2 8660 -1.97755 0.049035771 0.251515218 0.7582201 0.54679306 cg04943986 NR2F2 7026 1.97754 0.049036969 0.251515218 1.29867483 0.56842477
cg23310538 PLEKHA9 51054 -1.97746 0.049045848 0.251515218 0.76812732 0.55718032 cg04940515 RABGGTB 5876 1.97702 0.049095757 0.251636458 1.31212304 0.57129891 cg04439215 KCTD4 386618 -1.97702 0.049095808 0.251636458 0.75622031 0.57659338 cg08507270 TAS2R8 50836 -1.97672 0.049129865 0.251743542 0.76097844 0.57276119 cgl2385643 UGT1A6 54578 1.97639 0.04916768 0.251755709 1.31045443 0.56015531 cg04719766 KCNQ1 3784 -1.97638 0.049168648 0.251755709 0.76316059 0.56519766 cg07376535 ADCYAP1 116 1.97635 0.049171735 0.251755709 1.29919144 0.58450988 eg 12724466 ASB11 140456 -1.97611 0.049198998 0.251808066 0.77116861 0.5524405 cgl9532954 ID3 3399 1.97602 0.049209301 0.251808066 1.31093747 0.5742739 eg 10704923 HISTI HIT 3010 -1.97592 0.049221465 0.251808066 0.75605677 0.56020573 eg 16648297 ZNF576 79177 -1.97569 0.04924732 0.251828588 0.76694065 0.55400363 cg23278885 TGM6 343641 -1.97565 0.049251814 0.251828588 0.76039026 0.57472771 cg20713492 AQP10 89872 1.97517 0.049306467 0.251976106 1.30340889 0.56474385 cg25248094 SH2D1A 4068 -1.9751 0.049314447 0.251976106 0.76644992 0.55299516 cg07598199 MY0Z2 51778 -1.97476 0.049352927 0.251976106 0.76624873 0.5532977 cgl2213457 CHPT1 56994 1.97396 0.049444572 0.251976106 1.30730598 0.56600444 cg20802051 AK3L1 205 -1.97391 0.049450635 0.251976106 0.76095223 0.55707947 cg26354238 RQCD1 9125 1.97378 0.049465609 0.251976106 1.32498507 0.56615571 cg02457752 CDR1 1038 -1.97377 0.049466604 0.251976106 0.75298233 0.56111335 cg08831594 TSPAN15 23555 1.97371 0.049473434 0.251976106 1.30734422 0.55788624 cg09260089 NKX6-2 84504 -1.97367 0.049478562 0.251976106 0.7616518 0.58425777 cg06062132 SENP6 26054 1.97366 0.049479465 0.251976106 1.32436599 0.5734167 cg24739326 CHST8 64377 1.97363 0.049482007 0.251976106 1.30622905 0.57099637 cg09060914 SELP 6403 -1.97359 0.04948687 0.251976106 0.75933129 0.55254135 eg 17460846 C0X15 1355 1.97342 0.049506143 0.251976106 1.33397732 0.56736587 cgl0466917 TRY1 136541 -1.97339 0.04950982 0.251976106 0.76096688 0.56262606 cgl l212609 DULLARD 23399 1.97339 0.049510217 0.251976106 1.30603301 0.58859419 cg24734575 SLC7A9 11136 -1.97325 0.049526184 0.251976106 0.75293505 0.57155103 cgl0078829 KLK4 9622 -1.97321 0.049530974 0.251976106 0.77393781 0.55803752 cg20241335 NUPL1 9818 1.97316 0.049536712 0.251976106 1.30522894 0.56539936 cgl l032157 TAS2R50 259296 -1.97295 0.049560409 0.251976106 0.76651251 0.55516337 cgl4817143 TTPA 7274 1.97284 0.049573555 0.251976106 1.31810655 0.55793667 cgl3112511 PDE4D 5144 -1.97283 0.049574063 0.251976106 0.75731779 0.54714603 cgl8003231 SLC25A18 83733 -1.9727 0.049589305 0.251976106 0.7630279 0.56706333 cg23863670 CCL28 56477 -1.97251 0.04961119 0.251976106 0.76324437 0.56751714 cg05521696 SLC2A14 144195 1.97237 0.049627261 0.251976106 1.30494108 0.59595603 cg22220722 PLA2G2A 5320 -1.97228 0.049637277 0.251976106 0.76484338 0.57538322 cg24901474 RGS5 8490 -1.97219 0.049648193 0.251976106 0.76834049 0.57331585 cg25383242 CNTNAP4 85445 -1.972 0.049668991 0.251976106 0.76982165 0.57538322 cgl5677344 ADH1A 124 -1.97191 0.049679977 0.251976106 0.76533153 0.56212182 cgl6421285 SAE1 10055 1.97189 0.049681546 0.251976106 1.3021728 0.55914683 cg04167054 ATP2C1 27032 1.9718 0.049692068 0.251976106 1.3155188 0.58511497
cg23513690 SH3RF2 153769 1.9717 0.049703771 0.251976106 1.31528211 0.58708148 cgl4076411 RNGTT 8732 1.97163 0.049711747 0.251976106 1.31505092 0.56313029 cg21068152 SIRT4 23409 1.9716 0.049715726 0.251976106 1.30980645 0.57740016 cg21263122 SSTR1 6751 1.97119 0.049762225 0.251976106 1.31386157 0.57260992 cgl9318326 KIAA1919 91749 1.9711 0.049772935 0.251976106 1.31344514 0.55551634 cg01526089 P2RX1 5023 1.97096 0.049789415 0.251976106 1.32258357 0.57563534 cgl2941931 SEMA6B 10501 1.97087 0.04979928 0.251976106 1.31665278 0.56489512 eg 12406460 ATP5L 10632 1.97082 0.049804736 0.251976106 1.30638598 0.56963493 cg02828104 Kua 387521 1.9708 0.049807067 0.251976106 1.31264898 0.58425777 cg22617367 NKRF 55922 -1.9708 0.049807731 0.251976106 0.76482741 0.56070996 cg07757386 RAGE 5891 1.97053 0.049838867 0.252066938 1.30820833 0.56706333 eg 19844287 MOCS2 4338 1.97018 0.049878778 0.252119204 1.30495949 0.56055869 cgl2459502 BCL2 596 1.96996 0.049904526 0.252119204 1.31281865 0.56186971 cgl6492735 PEG10 23089 -1.96992 0.049908803 0.252119204 0.76216493 0.56529851 cg07112210 MGAT5B 146664 -1.96976 0.049927578 0.252119204 0.76296717 0.57558491 cgl3927251 FLT4 2324 1.96968 0.049936971 0.252119204 1.31289248 0.56575232 cg25371088 MRPL24 79590 1.96962 0.049943633 0.252119204 1.30582147 0.57235781 cg02266731 CPM 1368 1.96955 0.049951844 0.252119204 1.30621397 0.56388665 cgl5804118 DPM3 54344 1.96952 0.049954674 0.252119204 1.30324068 0.56040742 cg03533858 M0RN1 79906 -1.96899 0.050016689 0.2523615 0.75474342 0.56449173 cg25095814 CASP8 841 1.96888 0.050029076 0.2523615 1.32486772 0.55985276 cg25118574 PSMB7 5695 1.96873 0.050046589 0.252383264 1.31660783 0.55763413 cg06926735 UBE2V1 7335 1.96833 0.050092556 0.252413802 1.30585532 0.56686164 cg05657520 OPTC 26254 -1.96823 0.050104602 0.252413802 0.75941834 0.55728116 cg22699062 HSP90B1 7184 1.96794 0.050138084 0.252413802 1.30591227 0.58098023 cgl0221736 TICAM 1 148022 1.96791 0.050141002 0.252413802 1.30373544 0.58481242 cg03143365 MAN2B1 4125 1.96787 0.050145826 0.252413802 1.30678423 0.55107906 cgl lll3534 C20orf70 140683 -1.96778 0.050155933 0.252413802 0.76161191 0.56081081 cg26745032 REPS2 9185 -1.96778 0.050156422 0.252413802 0.7556316 0.55571803 cgl8534730 CABP5 56344 1.96769 0.050166715 0.252413802 1.29493188 0.56408834 cg05587474 MOV10 4343 1.96753 0.050184752 0.252413802 1.30976175 0.56444131 cg22373097 KRTAP21-1 337977 -1.96746 0.050193712 0.252413802 0.76163145 0.5725595 cg09279263 TADA3L 10474 1.96742 0.050197839 0.252413802 1.31005354 0.55828963 cg22674717 SALL1 6299 1.96708 0.050236906 0.252526111 1.29745891 0.55153288 cg26035366 LRRC3B 116135 1.9669 0.050258611 0.252526111 1.30399477 0.54563332 cg08822227 SH3BP2 6452 -1.96688 0.05025987 0.252526111 0.76619152 0.57709762 cgl4154330 ARHGAP27 201176 -1.96675 0.050275761 0.252526111 0.76047489 0.56630698 cg04513728 PPP1R10 5514 1.96663 0.050289627 0.252526111 1.31459437 0.54800323 cgl6075384 FU10099 55069 1.96631 0.050326126 0.252526111 1.30892917 0.59373739 cg24608774 STEAP1 26872 1.96628 0.050329497 0.252526111 1.31035685 0.57104679 cgl0771262 TCF21 6943 1.96622 0.050336775 0.252526111 1.30345819 0.55178499 cg02614187 TRIM45 80263 1.966 0.050362585 0.252526111 1.31521382 0.55738201
cgl2792367 TFR2 7036 1.96597 0.050365863 0.252526111 1.3178533 0.5830476 cg01693157 TUBA1 7277 -1.9659 0.050374732 0.252526111 0.76998811 0.56560105 cg00364814 R3HDM2 22864 -1.96581 0.050385051 0.252526111 0.75873537 0.57124849 cg04217178 ITM2B 9445 1.96575 0.050391845 0.252526111 1.30076495 0.57049213 cgl8374517 ALPPL2 251 -1.96522 0.050452878 0.252734143 0.76251703 0.59146833 cg21371335 DNAJC7 7266 1.96516 0.05045979 0.252734143 1.3156461 0.55874345 cg21665774 KIAA0355 9710 -1.96503 0.050474959 0.252743921 0.76635669 0.55707947 eg 14289985 ZNF471 57573 1.9647 0.050513761 0.252872 1.30141733 0.55697862 cg22336401 ENTPD8 377841 1.96455 0.050531586 0.252895031 1.31314861 0.54533078 cg27457941 RBP1 5947 1.96398 0.050597894 0.253160624 1.30919636 0.57366882 cg22189618 NAP1L3 4675 1.96368 0.050632263 0.253164846 1.2989171 0.59187172 cgl8834029 POLL 27343 -1.96359 0.050643184 0.253164846 0.75296263 0.58491327 cg07005767 ABRA 137735 -1.96347 0.05065689 0.253164846 0.75314133 0.56509681 cg21917349 APBA2 321 -1.96347 0.050657472 0.253164846 0.76200202 0.56792053 cg06468695 CCDC42 146849 -1.9634 0.050664932 0.253164846 0.76745059 0.54840662 cgl3296371 TMEM128 85013 1.96322 0.050686033 0.253202744 1.32202102 0.5524405 cg24076830 OR5V1 81696 -1.96311 0.050698998 0.253202744 0.75730191 0.55339855 cg07374637 KRTAP19-5 337972 -1.96288 0.050725642 0.253217558 0.76612377 0.57588746 cg01152019 HOXD4 3233 1.96284 0.050730996 0.253217558 1.30349925 0.56882816 cgl7291001 SERPINA13 388007 -1.96275 0.050741688 0.253217558 0.77039549 0.55380194 cg04574507 CD1B 910 -1.96242 0.050779613 0.253309815 0.76025048 0.55017144 cgl9230917 C20orf24 55969 -1.96223 0.050801884 0.253309815 0.77256088 0.58930012 cg01693108 SRPK1 6732 1.96205 0.050823296 0.253309815 1.30495524 0.58062727 cg07967308 ACP5 54 1.9617 0.05086479 0.253309815 1.30172274 0.57049213 cg05817232 MARK4 57787 1.96133 0.050907553 0.253309815 1.32038833 0.564643 cg24914244 RTN4IP1 84816 -1.96108 0.050936668 0.253309815 0.75571866 0.55208754 eg 16746462 LNPEP 4012 1.96093 0.05095404 0.253309815 1.32148761 0.55566761 cgl4481222 BIRC3 330 1.96088 0.050959958 0.253309815 1.3114467 0.55264219 cg25499017 CIT 11113 1.9608 0.050969287 0.253309815 1.33881543 0.55324728 cgl5945754 C6orf204 387119 -1.9607 0.050981756 0.253309815 0.75978296 0.56519766 cg22197787 KCNH1 3756 1.96045 0.051011067 0.253309815 1.30037514 0.56257564 cg06655089 IMPDH2 3615 1.96007 0.051055342 0.253309815 1.30914129 0.57024002 cgl5300989 SIP1 8487 1.95998 0.051066129 0.253309815 1.30376617 0.55622227 cgl l225935 JARID1A 5927 1.95994 0.051070601 0.253309815 1.29799323 0.57689593 cg09196959 TRIM40 135644 1.95993 0.051072614 0.253309815 1.30805513 0.55917205 cgl7342283 PRG1 5552 1.9597 0.051099107 0.253309815 1.30582141 0.55380194 cgl3007988 MLL2 8085 -1.95956 0.051115874 0.253309815 0.76806225 0.57482856 cg20394284 JAK2 3717 -1.95938 0.051136945 0.253309815 0.76410167 0.57124849 cg09448875 ABCC2 1244 -1.95916 0.051162152 0.253309815 0.76229959 0.56388665 cg05895453 KBTBD7 84078 1.95915 0.051163426 0.253309815 1.31001898 0.56106293 cgl5979098 ZNF615 284370 1.95905 0.051175799 0.253309815 1.30872928 0.58894716 cg02595219 KCNE3 10008 1.95882 0.051202947 0.253309815 1.30038343 0.55188584
cgl7296166 FU10781 55228 1.9588 0.051205486 0.253309815 1.30224019 0.56262606 cg04667458 Clorfl28 57095 1.95879 0.051205658 0.253309815 1.30758317 0.54139774 cg05275752 GALM 130589 1.95873 0.051212918 0.253309815 1.31696025 0.5682735 cg23110514 LCE3E 353145 -1.95863 0.051225513 0.253309815 0.76805287 0.56126462 cg26052367 GANC 2595 1.95862 0.051226506 0.253309815 1.31458775 0.57397136 eg 14984307 ACYP1 97 1.95831 0.051263115 0.253309815 1.30827481 0.58077854 cgl l368791 PFDN6 10471 1.9582 0.051275879 0.253309815 1.29043775 0.56136547 eg 18589624 INMT 11185 1.95814 0.051282917 0.253309815 1.30833651 0.56887858 eg 15760840 HOXA11 3207 1.95809 0.05128916 0.253309815 1.29504776 0.56318072 cg02153871 HARSL 23438 1.95803 0.051296444 0.253309815 1.30408301 0.57750101 cg08256781 ACSBG2 81616 -1.95802 0.051296746 0.253309815 0.77010222 0.55944938 cg02691091 SP2 6668 -1.95798 0.051301715 0.253309815 0.75981804 0.5629286 cgl5470750 FDPS 2224 1.95791 0.051310062 0.253309815 1.30410519 0.56106293 cg07534467 ZNF16 7564 1.9579 0.051310721 0.253309815 1.3070068 0.56620613 cg00807586 DLEC1 9940 1.9577 0.051335013 0.253309815 1.30729926 0.57210569 cg04270788 GTF2B 2959 1.95755 0.051352214 0.253309815 1.30866565 0.5639875 cgl0979891 SMOC1 64093 1.95729 0.051383434 0.253309815 1.29805424 0.54664179 cg02498063 CCDC60 160777 1.95724 0.051389373 0.253309815 1.31240016 0.57724889 cgl4611112 LCN6 158062 1.95718 0.051395834 0.253309815 1.30199781 0.55965107 cg04784672 LRFN5 145581 1.95698 0.051419548 0.253309815 1.30016936 0.57039129 cg22478614 DEFB4 1673 -1.9569 0.051429657 0.253309815 0.77163905 0.56595401 cgl0521267 ZNF684 127396 1.95686 0.051434285 0.253309815 1.31291229 0.57634127 cg24816866 PARK2 5071 -1.95677 0.051444638 0.253309815 0.75976974 0.55808794 cg25095612 NFKB2 4791 1.95676 0.051446297 0.253309815 1.31981243 0.55395321 cg08431931 MGC26816 164684 1.95671 0.051451365 0.253309815 1.30748804 0.59822509 cgl9305227 SLC28A2 9153 -1.95663 0.05146106 0.253309815 0.76376954 0.56706333 cg09405612 GLI3 2737 1.95659 0.051465887 0.253309815 1.31481214 0.5734167 cg03277112 CRSP3 9439 1.95658 0.051467474 0.253309815 1.31406927 0.57452602 cg06479216 IFNA16 3449 -1.95657 0.051468105 0.253309815 0.77255594 0.60379689 cg01425670 NEGRI 257194 1.95651 0.051475519 0.253309815 1.30856495 0.56968536 cgl5830940 SMARCALl 50485 -1.95646 0.051480857 0.253309815 0.76215765 0.57402178 cgl5357639 OGG1 4968 -1.95642 0.051485597 0.253309815 0.76355236 0.56318072 cg23147597 CEACAM 19 56971 -1.95622 0.051510143 0.253309815 0.76430153 0.58798911 cg01836044 PCDH20 64881 1.95618 0.051515051 0.253309815 1.30190372 0.56696249 cg03406535 RBP7 116362 1.95606 0.051528661 0.253309815 1.30469265 0.57250908 cg09034836 POM 121L1P 25812 1.956 0.05153562 0.253309815 1.30720209 0.57997176 cg09772154 FGFR2 2263 1.95595 0.051541713 0.253309815 1.29760657 0.56681121 cg20312475 GPRC5B 51704 1.95564 0.051577994 0.253422995 1.32109549 0.5779044 cgl0763059 PTP 12 5782 1.95506 0.051647296 0.2535601 1.3207792 0.56660952 cgl6169604 GPR148 344561 1.95493 0.051662613 0.2535601 1.29949596 0.57573618 egl 1114344 C17orf45 125144 1.95476 0.051683444 0.2535601 1.30751405 0.57220654 cg20002248 ACN9 57001 1.95465 0.051695751 0.2535601 1.30283133 0.56494554
cg00214855 C6orf79 63933 1.95464 0.051697349 0.2535601 1.30184715 0.56459258 cg25142416 CA1 759 -1.95456 0.051707159 0.2535601 0.76939319 0.54833098 cg00804048 EIF5A 1984 1.95425 0.051743864 0.2535601 1.32812246 0.55874345 cgl l795262 GATAD2A 54815 -1.95419 0.051751108 0.2535601 0.76869023 0.55798709 cgl6185365 RNF168 165918 1.95418 0.0517524 0.2535601 1.31014976 0.57281162 cgl8895813 ADAMTS5 11096 1.95416 0.051754768 0.2535601 1.29972403 0.57175272 cg23557926 CFH 3075 1.95409 0.051762416 0.2535601 1.32758246 0.55460871 cg08591489 CXorf56 63932 -1.95407 0.051765012 0.2535601 0.77047027 0.54860831 cgl2380764 IL19 29949 1.95389 0.051786796 0.253601842 1.31202114 0.56761799 cgl0585962 M0GAT2 80168 1.95357 0.05182427 0.25362034 1.31473749 0.55944938 cg25593948 TFAP2B 7021 1.95342 0.05184196 0.25362034 1.3208694 0.57845906 eg 18762485 CH25H 9023 1.95341 0.05184295 0.25362034 1.29773637 0.5697862 cgl9614321 RASSF2 9770 1.95306 0.051885194 0.25362034 1.3115179 0.56832392 cg22828602 RNF133 168433 -1.9529 0.05190416 0.25362034 0.7665522 0.55516337 cg27152280 NRG2 9542 1.95278 0.051918162 0.25362034 1.30901227 0.56544978 cgl6220802 MAP2K1IP1 8649 1.95267 0.051931581 0.25362034 1.32089461 0.57129891 cg06476606 IFIT2 3433 1.95251 0.051951238 0.25362034 1.3064628 0.56585317 cg24042452 Clotfl82 128229 -1.9521 0.051999233 0.25362034 0.75673865 0.55823921 cgl9690101 DHX57 90957 -1.95199 0.052013091 0.25362034 0.7555868 0.5577854 cgl7813891 EVL 51466 -1.95197 0.052015452 0.25362034 0.76286095 0.57064341 cgl8075454 MTRF1L 54516 1.95195 0.052017726 0.25362034 1.30434682 0.56822307 cg01533387 IFI30 10437 -1.95189 0.052025167 0.25362034 0.76379264 0.57129891 cg08261841 FU90586 135932 -1.95188 0.052025915 0.25362034 0.76631376 0.55481041 cgl2937807 LPHN1 22859 1.95188 0.052026245 0.25362034 1.31640061 0.55637354 cg20624391 BVES 11149 1.95179 0.052036625 0.25362034 1.29314411 0.57124849 cg24820250 CLEC2A 387836 -1.95173 0.05204388 0.25362034 0.76540101 0.56454215 cg04578090 PR0CA1 147011 1.95163 0.052055354 0.25362034 1.30692016 0.5682735 cgl6739580 POP2 152138 -1.9516 0.052059594 0.25362034 0.77051614 0.55097822 cgl5963971 FEN1 2237 1.9514 0.052083134 0.25362034 1.30825824 0.57250908 cgl0557828 PLOD2 5352 1.95129 0.052096314 0.25362034 1.31542999 0.55657523 cgl6555388 TNFSF10 8743 1.95108 0.052121724 0.25362034 1.30643865 0.57946753 cg03695693 ITGB1BP3 27231 1.95087 0.052146147 0.25362034 1.30804502 0.56050827 cg20780953 RAB3D 9545 1.95069 0.052168604 0.25362034 1.29659959 0.54694433 cg08372326 HABP4 22927 1.95064 0.052174293 0.25362034 1.29819717 0.56928197 cg23540745 HIST1 H4G 8369 -1.95055 0.052185305 0.25362034 0.76560855 0.56691206 cg00344372 HGFAC 3083 1.95033 0.052211021 0.25362034 1.31127927 0.55123034 cgl0488141 SUFU 51684 1.95029 0.052216519 0.25362034 1.29427027 0.55919726 cg26093711 VRK2 7444 1.95023 0.052223153 0.25362034 1.30490254 0.55803752 cgl8343292 MS4A7 58475 1.95016 0.052231457 0.25362034 1.31395828 0.56388665 cgl5750102 MGC16169 93627 1.95012 0.052236023 0.25362034 1.29648669 0.57714804 cg02943497 PARP4 143 1.9501 0.052239273 0.25362034 1.30406544 0.56872731 cg21187265 SEPN1 57190 1.95008 0.052240723 0.25362034 1.2979348 0.56434046
cg21052164 CH RNB2 1141 1.95008 0.052241503 0.25362034 1.30887741 0.56832392 0 0 0 0 0 cg26628634 NM E7 29922 1 .94941 0.052321931 0.253924721 1 .30169479 0.56403792 0 0 0 1 0 cg07489134 HELLS 3070 1 .94916 0.052351174 0.253924721 1 .30343099 0.54568374 0 0 0 1 0 cg01900048 SFT2D3 84826 1 .94906 0.052363964 0.253924721 1 .30797567 0.53791852 0 0 0 1 0 cg21642649 C21orf66 94104 1 .94892 0.052380229 0.253924721 1 .29283628 0.55602057 0 0 0 0 0 cg08343943 ALDH9A1 223 1 .94883 0.052391539 0.253924721 1 .30775684 0.56797096 0 0 0 0 0 cg26783353 SLC25A2 83884 - 1 .94879 0.052395623 0.253924721 0 .75093203 0.5580123 0 0 0 0 0 cg l7398312 FRM PD4 9758 - 1 .94869 0.052408081 0.253924721 0 .76922876 0.5639875 0 0 0 0 0 cg21942438 ZNF619 285267 - 1 .94861 0.052417833 0.253924721 0 .77299597 0.55526422 0 0 0 0 0 cg l6716983 DRP2 1821 - 1 .94856 0.052423707 0.253924721 0 .75926208 0.56676079 0 0 0 0 0 cg l l733245 IL2RA 3559 1 .94807 0.05248238 0.254144541 1 .31593928 0.56726503 0 0 0 0 0 cg21545849 CH D6 84181 - 1 .94744 0.052558822 0.254450278 0 .76801719 0.56560105 0 0 0 0 1 cg01462904 CCDC12 151903 1 .94705 0.052605116 0.254609939 1 .37701986 0.5648447 0 0 0 1 0 cg25827139 C17orf44 284029 - 1 .94662 0.052657144 0.25479727 0 .76559848 0.56676079 0 0 0 0 0 cg l l l85452 ERH 2079 1 .94617 0.052711687 0.254964315 1 .30262581 0.5584409 0 0 0 1 0 cg26534002 CSAG3A 389903 1 .94611 0.052718332 0.254964315 1.3082458 0.56045785 0 0 0 0 0 cg00798206 OXSR1 9943 1 .94594 0.052738969 0.25499963 1 .28876072 0.56751714 0 0 0 0 0 cg l3960192 GNA11 2767 1 .94519 0.052830373 0.255237526 1 .28658387 0.55496168 0 0 0 0 0 cg03584220 XCL2 6846 - 1 .94515 0.052835315 0.255237526 0 .76701072 0.53812021 0 0 0 0 0 cg05325699 HAP1 9001 1 .94514 0.052835655 0.255237526 1 .28979032 0.55788624 1 0 0 0 0 cg26170660 GPX5 2880 1 .94503 0.052849671 0.255237526 1 .29623171 0.56166801 0 0 0 0 0 cg03490200 A2M L1 144568 - 1 .94498 0.052854907 0.255237526 0 .76302091 0.57331585 0 0 0 0 0 cg25013058 NCOA7 135112 1 .94482 0.052875048 0.255270325 1 .30733187 0.56993748 0 1 0 0 0 eg 18482268 POU4F3 5459 1 .94465 0.05289583 0.255306203 1 .31806354 0.56787011 1 0 0 0 0 cg20525549 CRLF3 51379 1 .94432 0.052935195 0.255349991 1 .30697078 0.57477814 0 0 0 0 0 cg09299381 DNAL4 10126 1 .94419 0.052951586 0.255349991 1 .29643385 0.53927995 0 0 0 0 0 cg01784199 DNAJB4 11080 1 .94419 0.052951622 0.255349991 1 .31206538 0.57568576 0 1 1 0 0 cg l0202457 NM NAT2 23057 1 .94413 0.052958315 0.255349991 1 .30654771 0.55465914 0 0 0 0 0 cg00911351 PCDHGB4 8641 1 .94387 0.05298945 0.255435713 1 .29435369 0.5725595 0 0 0 0 0 cg00498604 TLL1 7092 1 .94375 0.053004798 0.255445305 1 .30640463 0.55924768 1 0 0 0 0 cg l l582100 GAD1 2571 1 .94349 0.05303562 0.25547011 1 .30167308 0.56413877 1 1 1 0 0 cg04508649 ANGPTL7 10218 - 1 .94348 0.053036664 0.25547011 0 .75922247 0.55617184 0 0 0 0 0 cg05942574 CACNA1G 8913 - 1 .94291 0.053106663 0.255552 0 .77351956 0.54744857 1 0 0 0 1 cg09038885 ADRA1B 147 1 .94287 0.053111606 0.255552 1 .29922002 0.56454215 0 0 0 0 1 cg l0569414 C21orfl21 150142 1 .94268 0.053134965 0.255552 1 .30657492 0.56671037 0 0 0 0 0 cg l7653969 SPHAR 10638 - 1 .94257 0.053147821 0.255552 0 .76959528 0.56897943 0 0 0 0 0 cg l l450827 CLDN5 7122 - 1 .94255 0.05314966 0.255552 0 .76283305 0.55531464 0 0 0 0 0 cg00887101 KIAA1698 80789 1.9423 0.053180297 0.255552 1 .31379205 0.56257564 0 0 0 0 0 eg 16786458 PPARGCI B 133522 1.94224 0.053188159 0.255552 1.2985218 0.55281868 0 0 0 0 1 cg l3041032 MM P13 4322 - 1.94223 0.053189064 0.255552 0.76635455 0.56328157 0 1 0 0 1 cg26780404 COL12A1 1303 1.94216 0.053197976 0.255552 1.2917353 0.58456031 1 0 0 1 0 eg 14440664 PDCD1LG2 80380 - 1.94206 0.053209993 0.255552 0.76418519 0.55990319 0 0 0 0 0
cg26124016 RARB 5915 1.94204 0.053212377 0.255552 1.29681375 0.57487898 RP11- cg00206052 529110.4 25911 1 .94199 0.053218264 0.255552 1 .31182591 0.57558491 cg08124030 TM4SF1 4071 - 1 .94188 0.053231311 0.255552 0, .76344821 0.56973578 cg07177852 CCDC68 80323 1 .94181 0.053240756 0.255552 1 .29510541 0.5672146 cg l8493147 C19orfl9 284451 1 .94156 0.053270824 0.255559783 1 .30063074 0.54336426 cg00631230 VPS33A 65082 1 .94122 0.053312677 0.255559783 1 .30492714 0.55082695 cg l9370284 ZNF38 7589 - 1 .94117 0.053318802 0.255559783 0.768333 0.57109722 cg l l538128 ZNF354C 30832 1 .94094 0.053345684 0.255559783 1 .30086779 0.56302945 cg l7978274 C15orf32 145858 - 1 .94093 0.053347284 0.255559783 0 .76246044 0.57003832 cg04946916 HUS1B 135458 1 .94088 0.053353827 0.255559783 1 .31463156 0.55707947 cg22691736 MTRF1 9617 1 .94081 0.05336185 0.255559783 1 .31195664 0.56318072 cg l2163132 TBX2 6909 - 1 .94048 0.05340199 0.255559783 0 .76877334 0.55344897 eg 19496782 GATA6 2627 1 .94047 0.053403036 0.255559783 1 .29776228 0.57755143 cg05000446 MGC41945 138724 1 .94046 0.053404947 0.255559783 1 .30917112 0.56605486 cg l3745346 CBFA2T3 863 1 .94037 0.053416129 0.255559783 1 .29594358 0.57008875 cg l9392109 FU39531 400360 - 1 .94023 0.053433153 0.255559783 0, .76263299 0.57039129 cg02962299 KIN 22944 - 1 .94021 0.05343572 0.255559783 0, .76719241 0.5680718 cg l8661868 FES 2242 1 .94008 0.053451672 0.255559783 1 .29381119 0.56918112 cg20727362 CYB5R3 1727 - 1 .94006 0.053454197 0.255559783 0, .76211885 0.55743243 cg l7850880 RNF6 6049 1 .94004 0.053456202 0.255559783 1 .29771149 0.55813836 cg09479015 KIRREL2 84063 1 .93967 0.053501477 0.255692446 1 .30165152 0.55289431 cg00178790 C18orfl9 125228 1 .93956 0.05351444 0.255692446 1 .30610559 0.56348326 cg l3430851 C10orf7 8872 1 .93928 0.053548505 0.255692446 1 .30682476 0.56504639 cg l l695358 MAPK15 225689 - 1 .93919 0.053560306 0.255692446 0 .76175948 0.56186971 cg l0720654 PTENP1 11191 1 .93916 0.05356373 0.255692446 1 .30094716 0.5639875 cg00155167 VPS13B 157680 1 .93895 0.053589403 0.255692446 1 .31841532 0.57649254 cg22369818 GABPB2 2553 1 .93892 0.053592953 0.255692446 1 .30188739 0.56908027 cg l5538820 OBP2B 29989 - 1 .93886 0.053601039 0.255692446 0, .76933447 0.57669423 cg03958426 MAPKAPK2 9261 1 .93883 0.053604291 0.255692446 1 .30574794 0.56771884 cg05313261 MAPK3 5595 1 .93863 0.053628988 0.255715353 1 .30038259 0.56081081 cg20757912 SSBP2 23635 1 .93857 0.053635837 0.255715353 1 .31212394 0.56958451 cg l5623573 APBA1 320 1 .93841 0.053655923 0.255747352 1.301181 0.58430819 cg01733599 LI PC 3990 - 1 .93819 0.05368269 0.255804125 0, .76531305 0.58511497 eg 19724470 CD274 29126 1 .93809 0.053694587 0.255804125 1 .29883424 0.55632311 cg27592112 GABRG3 2567 - 1 .93775 0.05373682 0.25594156 0, .76609963 0.55309601 cg l2811135 FU25369 200523 - 1 .93748 0.053769084 0.256031463 0, .76303587 0.57412263 eg 11177404 CGB2 114336 1 .93715 0.053809985 0.256136938 1 .29626114 0.56555063 cg20550520 ARHGAP5 394 1 .93703 0.053824815 0.256136938 1 .30653931 0.57225696 cg07745725 PSG3 5671 - 1 .93698 0.053831418 0.256136938 0, .76033098 0.58440904 cg l2058490 A2M 2 - 1 .93686 0.053846337 0.25614419 0, .76865907 0.58662767 cg02989257 COL16A1 1307 1 .93661 0.053876123 0.256217599 1.3071044 0.5368092
cg25374813 SLC23A1 9963 1.93647 0.053893175 0.256217599 1.30471186 0.58012303 cg06871974 TNS3 64759 -1.9364 0.053901964 0.256217599 0.77122363 0.58057685 cgl3315690 OVCA2 124641 1.93579 0.053977039 0.256505881 1.30033633 0.57003832 cg23123362 ICF45 54974 1.93569 0.053989438 0.256505881 1.30400933 0.57124849 cg01400401 C19orf30 284424 1.93543 0.054021545 0.25659467 1.31041671 0.57074425 cgl5169162 RDS 5961 -1.93516 0.054054705 0.256671336 0.76669954 0.5507261 cg22386774 CRYGA 1418 -1.93499 0.054075682 0.256671336 0.76447343 0.57190399 cgl3114389 ENTPD7 57089 1.93497 0.054077952 0.256671336 1.29684173 0.56872731 cg01425405 DLX3 1747 1.93483 0.054096217 0.256694314 1.29204845 0.55924768 cg02393447 C15orf20 80119 1.93469 0.054113673 0.256713447 1.28762224 0.55743243 cg23693510 ELAVL2 1993 1.93396 0.05420387 0.257032508 1.31063629 0.58057685 cgl3468685 PLEK 5341 1.93391 0.054209655 0.257032508 1.3036183 0.57669423 cgl7397493 PRLR 5618 -1.93381 0.054221252 0.257032508 0.77171418 0.57911456 cgl5557833 MGC33302 256471 1.93359 0.05424939 0.25710216 1.29205356 0.56151674 cg24176037 TBPL1 9519 1.93318 0.054299596 0.257156074 1.30932327 0.57535801 cg02351381 C12orf34 84915 1.93318 0.054299863 0.257156074 1.28466174 0.57896329 cg03132911 IQGAP2 10788 1.93317 0.054301109 0.257156074 1.29944288 0.56202098 cgl8508125 FBX016 157574 1.93286 0.054339681 0.25724209 1.30483175 0.58128278 cgl6940108 CANX 821 1.93268 0.054362002 0.25724209 1.31835793 0.55667608 cg22467567 IGFBP5 3488 1.93267 0.054363463 0.25724209 1.30364829 0.55627269 cgl2591323 SMARCALl 50485 -1.93251 0.054383307 0.25724209 0.7605673 0.56489512 cgl3372488 KCNT2 343450 1.93221 0.054419922 0.25724209 1.31068299 0.56787011 cgl6777782 CDH13 1012 -1.93218 0.054423865 0.25724209 0.7659038 0.54059096 cg25852715 OSBPL5 114879 -1.93217 0.054424925 0.25724209 0.7705018 0.56181928 cg04964702 CBL 867 1.93215 0.054426888 0.25724209 1.28989896 0.56297902 cg26276530 CMAS 55907 1.93185 0.054465022 0.25730572 1.29759382 0.56650867 cgl0846410 HSPA2 3306 -1.93163 0.054491648 0.25730572 0.77366244 0.56706333 cgl7630127 MS4A5 64232 -1.9315 0.054508083 0.25730572 0.76084772 0.53585115 cgl7741106 RDH14 57665 1.93147 0.054512374 0.25730572 1.30318139 0.5759883 cg24866437 ALPK1 80216 -1.9314 0.054520554 0.25730572 0.76979087 0.57099637 cgl5310162 CLDN14 23562 -1.9314 0.054521083 0.25730572 0.77166012 0.56423961 cgl6019273 EIF2C4 192670 -1.93074 0.054602345 0.2573293 0.77466961 0.55874345 cg06533629 KLF14 136259 1.93074 0.054602783 0.2573293 1.30572883 0.57301331 cg21042619 EED 8726 1.93069 0.054608758 0.2573293 1.31500719 0.56509681 cg20584011 ZDHHCl l 79844 -1.93069 0.054609041 0.2573293 0.76914998 0.56761799 eg 18843688 NUFIP1 26747 1.93068 0.054610069 0.2573293 1.29756781 0.56494554 cgl0546523 SEMA3B 7869 1.93067 0.054610791 0.2573293 1.30123334 0.54356595 cg04616566 THSD4 79875 -1.93039 0.054646303 0.2573293 0.76866261 0.59202299 cg23113963 SCNN1B 6338 1.93038 0.05464688 0.2573293 1.29583761 0.55657523 eg 18806980 KIAA0703 9914 -1.93038 0.054647189 0.2573293 0.77215552 0.5550121 cg01515887 SAA2 6289 -1.93001 0.054693966 0.257447896 0.76168072 0.560357 cg09469394 PEX13 5194 1.92996 0.0546993 0.257447896 1.30487335 0.56897943
cg25682936 SF3A3 10946 1.92962 0.054741899 0.257494137 1.29518962 0.52662364 eg 18020749 LRRC37A 9884 -1.9295 0.054756637 0.257494137 0.76566854 0.55223881 cg03668539 PEX11G 92960 -1.9295 0.054756975 0.257494137 0.76870574 0.54654094 cg26466094 AK5 26289 1.92945 0.054762985 0.257494137 1.29289755 0.56560105 cgl4657159 CIP29 84324 1.92916 0.054798745 0.257581169 1.30254366 0.5657019 cg21130124 CALML5 51806 -1.929 0.05481957 0.257581169 0.76803957 0.55753328 cgl3140740 ARL4 10124 -1.92891 0.054829884 0.257581169 0.75811793 0.57709762 cg02615157 PIN1 5300 1.92874 0.054851105 0.257581169 1.31269588 0.5699879 cgl8548413 PHB 5245 1.92867 0.054860689 0.257581169 1.31526718 0.57624042 cg22139563 KRTHA8 8687 -1.92859 0.054870356 0.257581169 0.76771507 0.56681121 cgl3959523 CHST8 64377 1.92821 0.054917445 0.257581169 1.29347528 0.55687777 eg 19008649 IGFBP5 3488 1.92816 0.05492389 0.257581169 1.3014506 0.57745059 cg21422208 RFT1 91869 1.92807 0.054936025 0.257581169 1.30510015 0.57039129 cg22213042 CPA2 1358 -1.92801 0.054942443 0.257581169 0.77262297 0.54664179 cgl0225525 FUT8 2530 -1.92796 0.054949006 0.257581169 0.77201015 0.56302945 cgl4289511 FU45256 400511 1.92781 0.054967842 0.257581169 1.28622278 0.58486285 cg27076046 DNMT3L 29947 -1.9278 0.05496965 0.257581169 0.77077429 0.56585317 cgl7286491 CEP350 9857 1.92779 0.054970072 0.257581169 1.30752874 0.54331384 eg 18422443 KITLG 4254 1.92764 0.054989693 0.257602951 1.30149969 0.56267648 cgl2686016 HOXA1 3198 1.92754 0.055001662 0.257602951 1.30455969 0.56081081 cgl9329389 TRIP4 9325 1.92717 0.055047451 0.25775428 1.29881748 0.57281162 cg07588779 BAD 572 1.92667 0.055110638 0.257986976 1.29846361 0.5472973 cg21902119 VAT1 10493 1.92638 0.055146881 0.258093458 1.30034279 0.55904599 cgl4760714 RPUSD2 27079 1.92624 0.055165155 0.258115812 1.30584058 0.57225696 cg07142319 PLA2G2D 26279 -1.92599 0.055196098 0.258197417 0.75420779 0.54689391 cgl6211684 PCDH21 92211 -1.92586 0.055212813 0.25821244 0.7676976 0.58108108 eg 10864941 LYZL4 131375 -1.92569 0.055233869 0.25824776 0.7685829 0.57230738 cgl2312863 AMDHD2 51005 1.92556 0.055249986 0.258259967 1.3044623 0.5674163 cgl5768203 PPIG 9360 1.92522 0.055292597 0.258334512 1.29437189 0.56973578 eg 19884658 KLHL21 9903 -1.92522 0.055292951 0.258334512 0.76603728 0.55425575 cgl6261965 ARF3 377 1.92509 0.055308725 0.258340277 1.30287952 0.57861033 cg08453096 ABCG5 64240 -1.92499 0.055321204 0.258340277 0.77087597 0.55944938 cg08956138 CD3E 916 1.92468 0.055360581 0.258461045 1.31283105 0.56403792 cg02690554 CITEDl 4435 1.92408 0.055435607 0.258730361 1.3048895 0.57740016 cg01421985 OTUD7 161725 -1.92399 0.055447207 0.258730361 0.76549612 0.56792053 cgl l513856 RABL5 64792 1.92381 0.055469468 0.258730361 1.29743631 0.57225696 cgl7309462 C20orf38 55304 1.92379 0.055472386 0.258730361 1.29109695 0.55627269 cgl9037167 TLR2 7097 1.92363 0.055492147 0.258759414 1.30423637 0.55405405 cgl4751914 SMAD7 4092 1.92352 0.055506116 0.258761453 1.30229526 0.56429004 cgl2177677 PSCDBP 9595 1.92337 0.055525629 0.258789334 1.32389747 0.55869302 cg24459563 CACNG1 786 -1.92313 0.055555423 0.258847727 0.75947745 0.55249092 cg05221264 ELA2A 63036 -1.92298 0.055574954 0.258847727 0.77156642 0.55334812
eg 18058949 NUP133 55746 1.9229 0.055584358 0.258847727 1.29366904 0.56131505 0 0 0 0 0 cg23657409 PLCB1 23236 1.92284 0.055592302 0.258847727 1.29221617 0.56237394 1 0 0 0 1 cg07070934 GJA4 2701 1.92261 0.055620856 0.258856625 1.30510319 0.57734974 0 0 0 0 0 cg05764376 THAP10 56906 1.92256 0.055627282 0.258856625 1.29455027 0.57018959 0 0 0 0 0 cg04281204 DCLRE1A 9937 1.9225 0.055634822 0.258856625 1.29002214 0.55995361 0 0 0 0 0 cg26224139 C9orfll6 138162 1.92187 0.055715437 0.258917874 1.30626724 0.56595401 0 0 0 0 0 cg04681849 PDGFRL 5157 1.92185 0.055717573 0.258917874 1.30643807 0.55854175 0 0 0 0 0 cg24523456 HLCS 3141 -1.92161 0.055747684 0.258917874 0.77199329 0.56383622 0 0 0 0 0 cgl4998713 ETS1 2113 1.9216 0.055749385 0.258917874 1.30108647 0.56444131 0 0 0 0 0 cgl0451565 GPR77 27202 1.92148 0.05576386 0.258917874 1.3036936 0.55960065 0 0 0 0 0 cg00211661 CENTD2 116985 1.92147 0.055765339 0.258917874 1.28094944 0.55894514 0 0 0 0 0 cg02019333 UPK1B 7348 -1.92135 0.055780661 0.258917874 0.7699288 0.55017144 0 0 0 0 0 cg21248478 CLIC2 1193 1.92132 0.055784699 0.258917874 1.2915409 0.57376967 0 0 0 0 0 cg02862362 ARG1 383 -1.92113 0.055808513 0.258917874 0.7690507 0.56141589 0 0 0 0 0 cgl3888886 SP011 23626 1.92113 0.055808517 0.258917874 1.30826594 0.56474385 0 0 0 0 0 cg22138461 FU13984 79828 1.92109 0.055813815 0.258917874 1.29074331 0.55657523 0 0 0 1 0 cg06619299 GMCL1L 64396 -1.92095 0.055831271 0.258917874 0.7542099 0.55168415 0 0 0 0 0 cgl9836199 RUNX1 861 1.92095 0.055831734 0.258917874 1.31866524 0.57346712 0 0 0 0 1 eg 14892066 DCTD 1635 1.92084 0.055844965 0.258917874 1.30186833 0.58556878 0 0 0 0 0 cg03098643 FAT 2195 1.92076 0.055855531 0.258917874 1.29276463 0.58783784 0 0 0 1 0 cg01114088 CYTL1 54360 1.92069 0.055864621 0.258917874 1.31562945 0.5892497 0 0 0 0 0 cg00605270 SMPDL3B 27293 1.92018 0.055929069 0.259123598 1.30119226 0.56660952 0 0 0 0 0 cg04345908 HLA-DQB2 3120 -1.92008 0.055941595 0.259123598 0.77623953 0.56141589 0 0 0 0 0 cg06230736 GATA3 2625 1.92002 0.055949659 0.259123598 1.29868174 0.58294675 1 0 0 0 0 eg 17408686 CHCHD6 84303 1.9198 0.055976904 0.259181389 1.28761279 0.57432432 0 0 0 0 0 cg23626798 L3MBTL 26013 -1.91971 0.055989244 0.259181389 0.77407718 0.54936466 0 1 0 0 0 cg27100123 SERPINB8 5271 -1.91953 0.056011776 0.259222939 0.7638509 0.54744857 0 0 0 0 0 cgl2359315 SLC6A20 54716 1.91936 0.056033477 0.259260629 1.30056976 0.56313029 1 0 0 0 0 cgl8695917 FSTL5 56884 1.9187 0.05611707 0.259584596 1.29911009 0.55682735 0 0 0 0 0 cgl5662251 PAQR7 164091 1.91857 0.05613364 0.259598447 1.29710056 0.55430617 0 0 0 0 0 cgl3153865 C8orfl 734 1.91846 0.056147301 0.259598844 1.29407785 0.57573618 0 0 0 0 0 cg02166313 PAPOLA 10914 1.91833 0.056164618 0.259615644 1.31235291 0.58213998 1 0 0 0 0 cg09936762 RAI17 57178 -1.91818 0.056182897 0.259615644 0.76675699 0.56524808 0 0 0 0 0 cg03414321 HCK 3055 1.91795 0.056213137 0.259615644 1.29960476 0.57190399 0 0 0 0 0 cg23719367 LONRF1 91694 -1.91791 0.056217203 0.259615644 0.77099078 0.55617184 0 0 0 0 0 cgl l716026 H19 283120 -1.9179 0.056218815 0.259615644 0.76147081 0.55183542 0 0 0 0 0 cgl6829154 NOTCH 1 4851 -1.91776 0.056237375 0.259638173 0.76788946 0.55803752 0 0 0 0 1 eg 18464559 ITGB3BP 23421 1.91765 0.056250848 0.259638173 1.29191979 0.57306374 0 0 0 0 0 cg21539243 PHTF1 10745 1.91732 0.056292832 0.259711268 1.30116991 0.55218838 0 0 0 0 0 cg01720520 LILRB1 10859 -1.91731 0.056293847 0.259711268 0.76373067 0.56373538 0 0 0 0 0 cg00772000 NHLRC1 378884 1.91716 0.056314029 0.25971584 1.29297695 0.57013917 0 0 0 0 0 cgl l237738 C4orf6 10141 -1.91709 0.056322 0.25971584 0.77216137 0.56494554 0 0 0 0 0
cgl2194493 PIGG 54872 1.91673 0.056368142 0.259771508 1.28837143 0.56918112 cg08665772 KCNJ9 3765 1.91666 0.056377813 0.259771508 1.29662976 0.59555264 cg25418748 RUFY1 80230 1.91662 0.056382569 0.259771508 1.30040569 0.57472771 cg20865068 TM9SF2 9375 1.91639 0.05641148 0.259771508 1.29944889 0.56282775 cg03289872 ZNF667 63934 1.91636 0.056415268 0.259771508 1.29649568 0.5657019 cg22552966 FU31196 146802 -1.91632 0.056420267 0.259771508 0.77384246 0.57250908 cgl l297236 PDILT 204474 -1.91625 0.056429163 0.259771508 0.76518654 0.56449173 cg08428707 CHMP4B 128866 1.91604 0.056457035 0.259826994 1.30030416 0.57205526 cg01873645 C9orf85 138241 1.91595 0.05646839 0.259826994 1.2917732 0.56161759 cg07395788 PDSS2 57107 1.9154 0.056538368 0.260024743 1.30746811 0.56988705 cg06691299 PCTK1 5127 -1.9154 0.056538562 0.260024743 0.7682047 0.55511295 cg06898923 RAB18 22931 1.91528 0.056553601 0.260031372 1.30177522 0.56731545 cg21705120 UBE2G1 7326 1.91498 0.056591901 0.26003613 1.29683197 0.56918112 cgl2971694 CD72 971 1.91498 0.056592842 0.26003613 1.29586802 0.56136547 cgl4143055 ADAMDECl 27299 -1.91487 0.056606864 0.26003613 0.77030743 0.58082896 cgl5239703 CBR4 84869 1.91485 0.056609029 0.26003613 1.28808361 0.56277733 cg09837803 IL16 3603 -1.91446 0.056658547 0.260146585 0.76347475 0.58698064 cg07959896 GEMIN6 79833 1.91439 0.056668421 0.260146585 1.29977077 0.5674163 cgl l783451 LOC90693 90693 -1.91424 0.056686605 0.260146585 0.76419971 0.55506253 cgl3337662 ATP12A 479 1.91424 0.05668749 0.260146585 1.28877044 0.5584409 eg 10708905 LRIG3 121227 -1.914 0.056718552 0.260178593 0.77426081 0.56161759 cgl9801560 HIST1 H4G 8369 -1.91397 0.056721676 0.260178593 0.76430029 0.54694433 cgl9385139 COL4A2 1284 1.9136 0.056769801 0.260336895 1.30184866 0.5534994 cgl5006396 NFKBIZ 64332 1.91348 0.05678465 0.260342559 1.31017243 0.56393707 cg00474004 IFNA14 3448 -1.91334 0.056802298 0.260361047 0.76436579 0.56320593 cgl6293656 FGF17 8822 1.9131 0.056834085 0.260444321 1.30087635 0.56070996 cgl7407908 AGER 177 1.91287 0.056863203 0.260453023 1.28565547 0.57936668 cg02278165 COX7A2L 9167 1.91278 0.056874835 0.260453023 1.29067652 0.56615571 cg04648087 TSC1 7248 1.91266 0.056890404 0.260453023 1.31665233 0.56908027 cg07328495 SMC2L1 10592 1.91259 0.056898837 0.260453023 1.30069711 0.56640783 cg04254119 AKAP3 10566 -1.91251 0.056909581 0.260453023 0.76984349 0.56444131 cgl9221369 TAF13 6884 1.91242 0.056921764 0.260453023 1.28845827 0.57588746 cg22568695 KIAA1468 57614 -1.91234 0.056931324 0.260453023 0.76624089 0.5398094 cgl7926057 PSMD10 5716 -1.91212 0.05695929 0.260518639 0.778199 0.5558693 cg26361780 CPB1 1360 -1.91184 0.056995285 0.260620939 0.7612059 0.54931424 cg21554552 RASSF1 11186 1.91143 0.057049183 0.260762172 1.30165133 0.55354982 cgl7503456 F0XL2 668 1.91138 0.057055289 0.260762172 1.30212798 0.56176886 cgl9035993 MGC50372 253143 -1.91121 0.057077653 0.260762172 0.7697278 0.54563332 cgl7532978 NEUR0D4 58158 1.91118 0.057080716 0.260762172 1.29707388 0.57452602 cgl0477754 PPRC1 23082 1.9109 0.057117494 0.260851708 1.30619209 0.55107906 cgl7542495 GJB1 2705 -1.91082 0.057127597 0.260851708 0.76773535 0.56323114 cgl6725097 EBNA1BP2 10969 1.91032 0.057191474 0.261081036 1.31481037 0.57250908
cg02198044 NEDD4 4734 1.91 0.057233956 0.261212612 1.29945883 0.56020573 cgl5034135 ADAMTS19 171019 1.9094 0.057311597 0.26150455 1.28625895 0.56363453 cg09013626 RYBP 23429 1.90907 0.057353537 0.261633488 1.30470733 0.58370311 cgl7914753 CYP2S1 29785 1.90889 0.057377186 0.261678949 1.30363389 0.58577047 cg20807545 ADAMTS18 170692 1.90876 0.057394607 0.261695987 1.2995552 0.55259177 cg22925006 ATP6V1C1 528 1.90857 0.057419177 0.261698672 1.29377631 0.56456737 cg08222662 ZC3HAV1 56829 1.90854 0.057422566 0.261698672 1.29502793 0.57024002 cgl0044101 VNN2 8875 1.90843 0.057436769 0.26170103 1.30598766 0.55995361 cg27560292 TAF10 6881 1.90821 0.057465655 0.261768313 1.28305718 0.56686164 cg06777715 ATGIO 83734 1.90805 0.057486454 0.261768313 1.29065265 0.56731545 cgl8809535 LDHAL6B 92483 -1.908 0.057492602 0.261768313 0.76991048 0.55894514 cg24921858 BCL2L14 79370 -1.90772 0.057528941 0.261837143 0.77686094 0.56519766 cg04645174 OR7A17 26333 -1.9076 0.057544196 0.261837143 0.76949699 0.54850746 cg22464423 IGSF4C 199731 1.90756 0.057550026 0.261837143 1.3028575 0.55602057 cgl3438944 MGC16028 112752 1.9071 0.057609079 0.261837143 1.30166369 0.56842477 cg26021476 ENY2 56943 1.9071 0.057610112 0.261837143 1.28903373 0.55718032 cg23254045 TMC05 145942 -1.9071 0.057610302 0.261837143 0.77767461 0.55428096 cg26884581 PYGM 5837 1.90694 0.057630828 0.261837143 1.30937059 0.55128076 cgl2281657 C14orf50 145376 1.90693 0.05763217 0.261837143 1.30168857 0.57815652 cg09906458 PRND 23627 -1.90665 0.057668578 0.261837143 0.76195381 0.5545835 cg05086993 NOL9 79707 1.90661 0.057672814 0.261837143 1.29319103 0.58299718 cg04838107 ARF6 382 1.9065 0.057687793 0.261837143 1.28296444 0.55551634 cg00136405 IL21 59067 1.90648 0.057689897 0.261837143 1.27719586 0.55965107 cg04291079 MEG3 55384 -1.9064 0.05770079 0.261837143 0.76849313 0.53711174 cgl l037424 C20orfl4 24148 -1.90636 0.057705893 0.261837143 0.77405409 0.56983663 cg05062178 ITGB5 3693 1.90631 0.057713104 0.261837143 1.28911199 0.56630698 cgl4737613 RA BP3 8498 1.90609 0.057741619 0.261849169 1.29223404 0.53287616 cgl5611923 RBM8A 9939 1.90588 0.05776833 0.261849169 1.29352843 0.58163574 cg02688643 MGST2 4258 -1.90587 0.057770511 0.261849169 0.76657876 0.56313029 cg26179948 JAZF1 221895 1.90585 0.057772021 0.261849169 1.29743843 0.57013917 cg25944100 MS4A3 932 1.90576 0.057784219 0.261849169 1.30785075 0.56222267 eg 11867686 PPP1CA 5499 1.9048 0.057909862 0.262275328 1.28768493 0.56353368 cgl6215361 MUC15 143662 -1.90478 0.057912629 0.262275328 0.76306663 0.56413877 cg00230271 MGC16169 93627 1.90472 0.057919409 0.262275328 1.31270282 0.57054256 cgl3262687 POU4F2 5458 1.90449 0.057949804 0.262320041 1.29532523 0.55889472 cgl0321723 PDZK1 5174 -1.90444 0.057956718 0.262320041 0.76203863 0.57119806 cg23662675 PRKCBP1 23613 1.90419 0.057989846 0.262407873 1.29852574 0.54976805 cg08242323 POLR2D 5433 1.9037 0.058053617 0.262634295 1.29141921 0.58022388 cgl7272491 GOLGA3 2802 1.9033 0.058105263 0.26275558 1.29227175 0.5725595 cg09194436 ALDH6A1 4329 1.90328 0.058107907 0.26275558 1.28299197 0.55017144 cg05449607 C6orf51 112495 1.90294 0.058153142 0.262867368 1.28936939 0.5785599 cgl5377649 ACTN4 81 1.90289 0.058160121 0.262867368 1.29365096 0.58032473
cgl4711016 NARFL 64428 1.90241 0.058222007 0.262996395 1.30418028 0.54638967 cgl7518962 GAL3ST4 79690 1.90241 0.058222093 0.262996395 1.30361344 0.56252521 cgl7171485 HEBP2 23593 1.90232 0.058234222 0.262996395 1.29244015 0.57382009 cg01071811 L3MBTL 26013 -1.90225 0.05824368 0.262996395 0.76678793 0.56010488 cg25023994 BANK1 55024 1.90214 0.058257927 0.262998626 1.28685038 0.53812021 cgl6812893 KRTAP15-1 254950 -1.90199 0.058277092 0.263023049 0.77789775 0.55652481 cgl7159537 PEX11G 92960 1.90183 0.058298091 0.263040747 1.28911183 0.55697862 cgl4078518 GK2 2712 -1.90174 0.058310704 0.263040747 0.77270217 0.57608915 cgl3337865 TEKT1 83659 1.90165 0.058322279 0.263040747 1.28953326 0.55849133 cg24674220 GMEB2 26205 -1.90141 0.058353787 0.26310919 0.76830872 0.56408834 eg 14008883 SLC18A3 6572 1.90122 0.058378585 0.26310919 1.29413768 0.56257564 cgl6091845 SMARCA5 8467 1.90114 0.058388888 0.26310919 1.28534413 0.57608915 cgl l479591 MECP2 4204 -1.90104 0.058402673 0.26310919 0.77581071 0.56307987 cgl l221513 C22orf9 23313 1.90098 0.058409801 0.26310919 1.29829066 0.55602057 cg23013392 PARP3 10039 -1.90091 0.058420007 0.26310919 0.77262289 0.56403792 cgl l762346 HKDC1 80201 -1.89988 0.058555553 0.263529136 0.77363763 0.57926583 cg25140501 ACINI 22985 1.8998 0.058565319 0.263529136 1.28266798 0.54886043 cgl l483915 SLC40A1 30061 1.89974 0.058574313 0.263529136 1.29134222 0.58042558 cg23618830 ARHGEF12 23365 1.8997 0.058578981 0.263529136 1.30796508 0.57271077 cg05395196 HSF2 3298 1.89968 0.058582155 0.263529136 1.28750448 0.57603873 cg00020533 TULP1 7287 -1.89954 0.058600338 0.263548934 0.76272907 0.55914683 cg26025891 PSTPIP1 9051 -1.89925 0.058637974 0.263565868 0.78216957 0.57124849 cg04490714 SLC6A2 6530 -1.89921 0.058643325 0.263565868 0.76598413 0.55249092 cg26689483 QDPR 5860 1.8992 0.058645451 0.263565868 1.29620557 0.56333199 cgl7881637 MRPL40 64976 -1.89862 0.058721904 0.263712953 0.76961598 0.55128076 cg05538432 CIS 716 -1.89856 0.05872922 0.263712953 0.76982064 0.5532977 cgl l091262 GALNTL5 168391 -1.89852 0.058735167 0.263712953 0.77074266 0.57139976 cgl2378831 KIAA0853 23091 1.89841 0.058749038 0.263712953 1.28995669 0.57815652 cgl3369981 BCDIN3 56257 1.89833 0.058760024 0.263712953 1.29048307 0.55128076 cg20840847 APBA2 321 -1.8983 0.058763673 0.263712953 0.7687186 0.55395321 cg06954481 GBX2 2637 1.89822 0.058774711 0.263712953 1.29261732 0.55365067 cgl5350194 FAM70B 348013 1.89798 0.05880662 0.26379423 1.28897895 0.55440702 cgl4961385 SPAG4 6676 1.89778 0.05883335 0.2638267 1.29776709 0.56555063 cg27056559 MGMT 4255 -1.89767 0.058846854 0.2638267 0.76732972 0.56444131 cgl9070798 LOC129138 129138 1.89761 0.058855248 0.2638267 1.28818846 0.56247479 cg00690893 RAB9A 9367 1.89738 0.058885053 0.263898443 1.30180069 0.56706333 cgl5031780 PEX14 5195 1.89728 0.058899243 0.263900193 1.30454841 0.5541549 eg 16640096 COL4A3 1285 -1.89708 0.05892587 0.26390628 0.77921755 0.54412061 cgl0563284 PAK6 56924 1.89706 0.058928203 0.26390628 1.29519596 0.57281162 cg25336198 INS 3630 -1.8969 0.058949594 0.26392908 0.77380652 0.56988705 cgl0957200 HSPA14 51182 1.89681 0.058960898 0.26392908 1.29563606 0.55602057 cg03445474 GPIAP1 4076 1.89671 0.058974717 0.26392916 1.28358381 0.58834207
cgl0537269 TIMM9 26520 1.8963 0.059028909 0.264109874 1.29539557 0.55823921 cg25671438 CENTB1 9744 1.89615 0.059048938 0.264137687 1.29440656 0.55481041 cg08661290 PHF13 148479 1.89596 0.059073796 0.264187084 1.29090579 0.57069383 cgl4117297 MGC23244 126259 1.89569 0.059109321 0.264284151 1.28429939 0.55254135 cg24874111 ZNF562 54811 1.89548 0.059137879 0.264350029 1.29733192 0.53161557 cgl6218424 CMAS 55907 1.89511 0.059187352 0.264509347 1.29394841 0.55914683 cg05423257 ALPI 248 -1.89481 0.059226446 0.264548424 0.76592032 0.56590359 cg23641145 PGR 5241 1.8948 0.059228117 0.264548424 1.30370037 0.55556676 cg07125991 LOC196463 196463 -1.89468 0.059243966 0.264548424 0.77093068 0.57271077 cgl3265003 SLC37A1 54020 1.89454 0.059262402 0.264548424 1.2922857 0.56691206 cgl4448116 ADAMTS4 9507 -1.89452 0.059265266 0.264548424 0.7663209 0.55531464 cgl6237595 RNF41 10193 1.89418 0.059310817 0.264689968 1.30551732 0.57503025 cgl7386185 GLYCTK 132158 -1.89392 0.059346114 0.264743804 0.7731657 0.55274304 cg02260587 PCDHB2 56133 1.89388 0.059350569 0.264743804 1.28790252 0.55965107 cg06730468 FU10922 55260 1.8937 0.059374536 0.264774611 1.29110935 0.56212182 cg01120307 LOC349236 349236 -1.89362 0.059385167 0.264774611 0.76932663 0.54618798 cg03070588 USP30 84749 1.89347 0.059405811 0.264804913 1.28554994 0.56479427 cg03041841 C9otf75 286262 1.89319 0.059443099 0.264909376 1.2967896 0.54820492 cgl5238224 TRIM31 11074 -1.89289 0.059482523 0.264966493 0.77089657 0.5744756 cg26071978 HMFN0839 84803 1.89289 0.059483627 0.264966493 1.28540866 0.56429004 eg 14464791 DDX6 1656 1.89248 0.059538025 0.265086076 1.29410466 0.56615571 cg09321965 NEK7 140609 -1.89242 0.059545245 0.265086076 0.7745299 0.56595401 cgl l654737 BCKDHB 594 1.89237 0.05955206 0.265086076 1.29804409 0.5759883 cg23347958 DHX8 1659 1.89203 0.059598053 0.265229071 1.29368243 0.55990319 cg24317255 RGS17 26575 1.89153 0.059664941 0.265464959 1.30438932 0.55591973 cg25152942 MIA 8190 -1.89138 0.059685735 0.265495706 0.76299273 0.55813836 cg21660130 CLCNKB 1188 -1.89097 0.059740622 0.265678056 0.77578745 0.54941509 cg27124774 PCDHB10 56126 1.89068 0.059778835 0.265754311 1.29736523 0.56706333 cg24573310 C10orf70 55847 1.89055 0.059795823 0.265754311 1.29875373 0.56388665 cg21685266 EHHADH 1962 1.89053 0.05979946 0.265754311 1.2939184 0.58682937 cg22658979 MMP13 4322 -1.89018 0.059845936 0.265899062 0.77084469 0.56529851 cg26965059 ATF2 1386 1.88933 0.05996002 0.266262251 1.28887374 0.57956837 cg20918903 JMJD1A 55818 1.8893 0.059964239 0.266262251 1.29951964 0.564643 cg22639768 FAM 13C1 220965 1.88919 0.05997925 0.266262251 1.28845614 0.53191811 cg00152644 SPRR2E 6704 -1.88916 0.059983374 0.266262251 0.76285483 0.56081081 cg03691812 COR01A 11151 -1.88878 0.060034284 0.266384256 0.7734764 0.59192215 cgl3948987 HCRTR2 3062 1.88868 0.060047777 0.266384256 1.29365716 0.5873336 cg05886367 BTNL9 153579 1.88864 0.06005265 0.266384256 1.30672228 0.57190399 cg24391122 SNAPC2 6618 1.88845 0.06007894 0.266414706 1.30110284 0.56650867 cgl3118748 C6orfl36 221545 -1.88839 0.060087378 0.266414706 0.72572481 0.57921541 cg23404467 KIR3DL3 115653 -1.88786 0.060158448 0.266588142 0.7646626 0.55556676 cg00241355 GAPDH 2597 1.88778 0.060168492 0.266588142 1.29864401 0.54376765
cgl3246592 P2RX5 5026 1.88776 0.060171398 0.266588142 1.28431621 0.56186971 cg23764381 ATR L1 26033 1.88768 0.060182981 0.266588142 1.29338327 0.57689593 cg25462291 HEYL 26508 1.88753 0.060203102 0.266588142 1.28320371 0.56862646 cgl0612997 GREB1 9687 -1.88746 0.060212685 0.266588142 0.77119119 0.560357 cg05253327 B3GNT1 10678 -1.88737 0.06022408 0.266588142 0.77524034 0.5697862 cg03218909 HAPLN2 60484 1.88721 0.060245857 0.266622821 1.30190014 0.54442315 cg25072962 MGC35295 219995 -1.88665 0.060322263 0.266829518 0.772808 0.56282775 cg01161597 TAF2 6873 1.8866 0.060328355 0.266829518 1.29375594 0.57321501 cg02020018 PRRG3 79057 -1.88655 0.060335429 0.266829518 0.7679441 0.55566761 cgl4579051 COL9A1 1297 -1.88632 0.060365762 0.266829518 0.7736283 0.55541549 eg 10396470 NUP107 57122 1.88625 0.060376116 0.266829518 1.29416089 0.56217225 cg25488021 EPB41L2 2037 -1.88625 0.060376282 0.266829518 0.77294867 0.560357 cg25160554 ARL6 84100 1.88584 0.060430573 0.266880837 1.29690831 0.54749899 cg02027010 ALAD 210 1.88565 0.060457407 0.266880837 1.28859033 0.56565147 cg00955451 APBA2 321 -1.88554 0.060472297 0.266880837 0.7689116 0.57260992 cgl5798153 PFTK1 5218 -1.88539 0.060492188 0.266880837 0.77220412 0.55854175 cg20755353 SSU72 29101 1.88538 0.060493046 0.266880837 1.29396958 0.54573417 cgl3387232 FU34443 285464 -1.88532 0.060501752 0.266880837 0.77000242 0.55793667 cgl7617223 ZYG11BL 10444 1.88501 0.060543648 0.266880837 1.2863017 0.55985276 cgl0889792 KRTAP5-9 3846 -1.88498 0.060548345 0.266880837 0.77795385 0.54507866 cg21612046 ZNF550 162972 1.88492 0.060555329 0.266880837 1.29842363 0.57432432 cgl2213910 RAET1E 135250 -1.88488 0.060561173 0.266880837 0.76398858 0.56514724 cg01861509 SPOCK2 9806 -1.88483 0.060568516 0.266880837 0.767154 0.58040036 cg27119451 BRD8 10902 1.88481 0.060571213 0.266880837 1.30725493 0.56620613 cg27559343 SETD3 84193 -1.88476 0.060578046 0.266880837 0.77691226 0.56489512 cg20028470 UCN 7349 1.88465 0.060592056 0.266880837 1.27765241 0.5768455 cg22927153 MAP2K5 5607 1.88451 0.060610842 0.266880837 1.28626831 0.55284389 cgl9521927 PLA2G5 5322 -1.88445 0.060619844 0.266880837 0.77156747 0.55990319 eg 16054422 SART3 9733 1.88441 0.060625147 0.266880837 1.3042219 0.57281162 cgl5310873 C20orf85 128602 -1.88421 0.060652336 0.266899409 0.77305758 0.56817265 cgl8516268 RPL23 9349 -1.88413 0.060662883 0.266899409 0.76883667 0.55153288 cg24836175 CSNK2B 1460 1.88393 0.060690917 0.266899409 1.28419554 0.54961678 cg00134539 UBASH3A 53347 -1.88385 0.060701625 0.266899409 0.7718931 0.57780355 cg27403822 TOR3A 64222 1.88381 0.060706353 0.266899409 1.28340075 0.58193828 cg26025944 SCNN1G 6340 1.88376 0.060713108 0.266899409 1.29894075 0.53186769 cg24592364 ANKH 56172 -1.8836 0.060734534 0.266924923 0.77189954 0.55914683 cgl4365123 ARPM2 140625 -1.88342 0.060759319 0.266924923 0.77767802 0.56822307 cgl3199822 ATP6V1A 523 1.8832 0.060788821 0.266924923 1.2897421 0.57780355 cg01222684 TTC1 7265 1.88319 0.060791417 0.266924923 1.2984776 0.57755143 cg05890484 BHMT 635 1.88318 0.060792139 0.266924923 1.28586021 0.56444131 cg02880176 LOC201164 201164 1.88295 0.060823396 0.266924923 1.30630427 0.56792053 cgl2360886 GSDML 55876 -1.88295 0.060823473 0.266924923 0.76747412 0.55259177
cg04995717 TE 7010 1.88282 0.060841315 0.266924923 1.29339953 0.56817265 cgl l469137 PLOD1 5351 1.8828 0.060844537 0.266924923 1.29473212 0.55808794 cg22705225 PDZK3 23037 -1.88235 0.06090534 0.266979952 0.78013564 0.5584409 cgl9099213 SPP2 6694 -1.88234 0.060906117 0.266979952 0.77340916 0.55077652 cg07000831 SETDB2 83852 1.8823 0.060912019 0.266979952 1.28653898 0.54936466 cg06536578 JPH4 84502 -1 .88224 0.060920746 0.266979952 0.76630209 0.556071 cgl8138552 PSMD8 5714 1 .88219 0.060926887 0.266979952 1.28649423 0.56544978 cg00620024 PPP6C 5537 -1 .88191 0.060965457 0.267058819 0.7700984 0.55975192 cg05140736 SGSH 6448 1 .88183 0.060976762 0.267058819 1.28685574 0.56958451 cgl8084114 MATN1 4146 -1 .88166 0.060998946 0.267058819 0.77183919 0.56217225 cgl3683864 RPL14 9045 1 .88163 0.061003624 0.267058819 1.28186395 0.55591973 cgl l465971 GSH2 170825 1 .88155 0.061014712 0.267058819 1.28703378 0.55828963 cgl2285118 FAM 107B 83641 -1 .88132 0.061046245 0.267135693 0.77551603 0.56202098 cg22009138 ERBB2IP 55914 1 .88113 0.061072128 0.26713577 1.28582787 0.55581888 cgl9220825 AQP5 362 1 .88108 0.061078358 0.26713577 1.31002699 0.56202098 cg21172540 TSSK3 81629 1 .88101 0.061088171 0.26713577 1.28274161 0.56857604 cg03475172 USP6NL 9712 1 .88087 0.061107419 0.267150888 1.2948145 0.5717023 cg09223071 SUPT7L 9913 1 .88051 0.061156362 0.267150888 1.28255958 0.55354982 eg 12044689 HIATL1 84641 -1 .88049 0.061159599 0.267150888 0.76721792 0.56318072 cgl8616655 SSX5 6758 -1 .88048 0.061161111 0.267150888 0.76242546 0.54991932 cg26705561 SEC31L2 25956 1 .88047 0.061161479 0.267150888 1.28613136 0.5663574 cg23128146 DCTN4 51164 1 .88025 0.06119147 0.267220851 1.30415997 0.56852562 cgl3043509 GIMAP5 55340 1 .87993 0.061236397 0.267355994 1.2971723 0.56908027 cg22498840 MCART1 92014 1 .87974 0.061262087 0.267407103 1.28601378 0.56010488 cg25243721 XRCC4 7518 1 .87945 0.061301559 0.267518332 1.28210727 0.57669423 cg22605643 RGS4 5999 1 .87932 0.061319714 0.267536506 1.28077819 0.55455829 cgl5133363 HIG2 29923 1 .87894 0.061371034 0.2676464 1.29537458 0.5813332 cg01220033 WDR34 89891 1 .87891 0.061375383 0.2676464 1.29914214 0.5655002 cgl6665103 COQ3 51805 1 .87883 0.06138689 0.2676464 1.31305379 0.54129689 eg 19776090 SUM02 6613 -1 .87859 0.061419774 0.26772873 0.77401318 0.53418717 cg05950276 TMTC4 84899 -1 .87821 0.061470966 0.267805593 0.77604669 0.56842477 cgl5125424 SOCS2 8835 1 .87812 0.061483293 0.267805593 1.29099437 0.5751311 cg26832142 PDE4B 5142 1 .87808 0.06148896 0.267805593 1.28481899 0.56272691 cgl4188111 S100A13 6284 -1 .87805 0.061493424 0.267805593 0.77373289 0.56242437 cgl4011639 PCDHGB7 56099 1 .87774 0.061535813 0.267826005 1.27871774 0.58864462 cgl7742155 ATP6V1G1 9550 1 .87768 0.061543673 0.267826005 1.29080127 0.58335014 cgl7043155 MRPL19 9801 1 .87767 0.061545788 0.267826005 1.28153126 0.55639875 cg02801598 PDP2 57546 1 .87734 0.061591087 0.267826005 1.29344368 0.56151674 cg27494383 LTK 4058 1 .87732 0.061594183 0.267826005 1.28343658 0.54412061 cg04514469 C14orf49 161176 -1 .87728 0.061599093 0.267826005 0.77456738 0.58995563 cg06544198 TMEM14C 51522 1 .87721 0.061609011 0.267826005 1.28568224 0.5691307 cg25994725 C6orf81 221481 - 1.8772 0.061610155 0.267826005 0.77010912 0.56489512
cg07800320 ALDH1L1 10840 1.87681 0.061663962 0.267912785 1.2897718 0.56313029 cg02433905 ATP6V1A 523 1.8768 0.06166559 0.267912785 1.30199349 0.56938282 cgl8989919 C3orf36 80111 -1.87669 0.061681221 0.267912785 0.77038424 0.57119806 cgl7234150 CACNG3 10368 1.87665 0.061686158 0.267912785 1.29635358 0.57134933 cg l3614181 RGC32 28984 -1.87653 0.061701963 0.267920577 0.77464258 0.58077854 cg22189286 HSPB8 26353 - 1.8763 0.061734447 0.268000775 0.77339113 0.56519766 cgl6592658 EBI3 10148 -1 .87579 0.061804409 0.268139606 0.77144603 0.55334812 cg23424268 GCHFR 2644 1 .87577 0.061807286 0.268139606 1.29148229 0.54477612 eg 11266874 ARL13B 200894 1 .87576 0.061808492 0.268139606 1.29103635 0.56877773 cgl5236866 DLX1 1745 1 .87565 0.061824447 0.268144643 1.30660288 0.56333199 cgl3672342 WDR39 9391 1 .87552 0.061842204 0.268144643 1.29469727 0.56212182 cg21939482 MGC12966 84792 -1 .87545 0.06185172 0.268144643 0.77228656 0.56983663 cg27628312 EPHB6 2051 1 .87528 0.061874535 0.268182754 1.29324551 0.56272691 cg21201572 AGR2 10551 -1 .87498 0.061916162 0.268266411 0.77748324 0.56776926 cg07357256 MRPS26 64949 1 .87491 0.061926505 0.268266411 1.28344406 0.55970149 cgl7067993 CCR7 1236 1 .87484 0.061935922 0.268266411 1.28164988 0.56222267 cg02082571 CLEC4A 50856 1 .87455 0.061976428 0.268381071 1.29452098 0.54003631 cg04590978 CC J 54619 1 .87427 0.062015052 0.268449584 1.28681708 0.55178499 cg00679556 TRIM31 11074 -1 .87423 0.062020326 0.268449584 0.77759928 0.55556676 cg00128654 C14orfl02 55051 1 .87406 0.062043307 0.268488282 1.28904693 0.5594998 cg22471346 GAS 7 8522 1 .87346 0.062127158 0.268732693 1.30411243 0.54437273 cgl7155167 RIT1 6016 1 .87345 0.062127892 0.268732693 1.28014748 0.55955022 cgl2914657 GIMAP1 170575 1 .87305 0.06218414 0.268889044 1.30253522 0.57215611 cg21073927 GATA4 2626 1 .87299 0.062192161 0.268889044 1.3021265 0.57578661 cg08090396 NEK4 6787 1 .87281 0.06221648 0.268933385 1.28389206 0.56418919 cg03439805 C0R01C 23603 1 .87206 0.062320966 0.269324153 1.28931555 0.55667608 cgl2699145 TMC7 79905 1 .87193 0.06233856 0.269337131 1.28043257 0.55914683 cg27541374 LOC51136 51136 1 .87183 0.062352138 0.269337131 1.28914427 0.59121622 cg05150177 SYT11 23208 1 .87152 0.062395583 0.269373946 1.30506571 0.56076039 cg21096399 MCAM 4162 1 .87148 0.062401009 0.269373946 1.28405475 0.54593586 cg26538116 LRPPRC 10128 1 .87139 0.062414411 0.269373946 1.29469234 0.5768455 cg23391785 DNM3 26052 1 .87131 0.062424633 0.269373946 1.28828626 0.57195442 cg26922202 OR2S2 56656 -1 .87127 0.062431093 0.269373946 0.76220633 0.54217931 cg23613177 C10orf89 118672 1.871 0.062468237 0.26947341 1.27873506 0.56691206 cg07246225 ZFHX1B 9839 1 .87088 0.062484954 0.269484733 1.28194021 0.56686164 cg25985437 FAM96A 84191 1 .87004 0.062601947 0.269585588 1.29194628 0.56313029 cg l2674192 RBM 13 84549 1 .87003 0.062603408 0.269585588 1.30389798 0.56338241 cg23111544 REG1A 5967 -1 .87001 0.062606045 0.269585588 0.77751165 0.57024002 cg22467071 PECAM1 5175 1 .86989 0.062622709 0.269585588 1.28954761 0.55465914 cg05412531 C8orf78 157376 -1 .86985 0.062628408 0.269585588 0.76819081 0.54800323 eg 11438428 PTF1A 256297 -1 .86982 0.062632555 0.269585588 0.77387965 0.56711376 cg01261503 POLG2 11232 1 .86969 0.062650187 0.269585588 1.29416099 0.5753328
cg05417985 ENPP1 5167 1.86969 0.062651451 0.269585588 1.29357076 0.56605486 cg22082243 C10orf84 63877 1.86959 0.062664229 0.269585588 1.30076557 0.56328157 cg07288587 CSNK1G1 53944 1.86959 0.062664441 0.269585588 1.28617417 0.56459258 cg01035238 TNFAIP6 7130 -1.86956 0.062668744 0.269585588 0.77123636 0.55284389 cg07816074 SH3TC1 54436 1.8695 0.062677509 0.269585588 1.28940198 0.55924768 cgl3437593 THRAP4 9862 1.86925 0.06271155 0.269617784 1.29625843 0.56429004 cg01906717 IFNA13 3447 -1.86914 0.062727045 0.269617784 0.7765447 0.55738201 cgl0693071 TRIM36 55521 1.86903 0.062742474 0.269617784 1.29132583 0.57089552 cg26943001 SPAG8 26206 1.86899 0.062748496 0.269617784 1.29588027 0.56595401 cg20769774 CYLD 1540 1.86894 0.06275549 0.269617784 1.28465244 0.55899556 cg24292612 DEFB1 1672 1.86879 0.062776415 0.26964144 1.29692398 0.58723276 cgl9824362 NR2C1 7181 1.86866 0.062794539 0.26964144 1.30038428 0.56383622 cg23871659 TANK 10010 1.86827 0.062849088 0.26964144 1.30517344 0.55249092 cgl0031456 RASGRP3 25780 -1.86804 0.062881478 0.26964144 0.77299718 0.56943324 cg01369413 UBQLN3 50613 -1.86803 0.062882749 0.26964144 0.77017167 0.56983663 cg22362636 TNIP2 79155 1.86786 0.062905966 0.26964144 1.30102463 0.5699879 cg07694025 SFRP2 6423 1.8678 0.062915504 0.26964144 1.28201263 0.5558693 cgl6155382 GRHL3 57822 1.86778 0.062917543 0.26964144 1.29897737 0.57785397 cgl3992856 FLOT2 2319 1.86767 0.06293335 0.26964144 1.28861464 0.55465914 cg27182555 THAP9 79725 1.86752 0.062953947 0.26964144 1.28131512 0.55213796 cg26457013 TMEM86B 255043 1.86747 0.062960906 0.26964144 1.29839166 0.54770069 cgl6873684 ORC2L 4999 1.86736 0.062976338 0.26964144 1.29360234 0.56469343 cgl6826286 LYZL6 57151 -1.86733 0.062980081 0.26964144 0.774952 0.54356595 cg23487586 MGC22001 197196 -1.86726 0.06299117 0.26964144 0.77498006 0.55314643 cg09812049 WIRE 147179 1.86724 0.062992951 0.26964144 1.29967981 0.54069181 cgl0753073 UBE2U 148581 -1.86721 0.062997888 0.26964144 0.76422547 0.55627269 cg22731373 PCYT1B 9468 -1.86719 0.063000704 0.26964144 0.77942874 0.54391892 cgl9098314 GOSR1 9527 1.86683 0.063050994 0.269796299 1.28535049 0.56822307 eg 19700658 UCP3 7352 -1.86655 0.063090626 0.269905487 0.77584537 0.56070996 cg l3383572 PRH 1 5554 -1.86641 0.06311021 0.269928885 0.77697848 0.56792053 cg22580173 THBS1 7057 1.86606 0.063159114 0.270077646 1.28485155 0.54583501 cg05654164 Clorf52 148423 -1.86565 0.063215882 0.270259959 0.77200696 0.54427188 cg20251973 MGC11266 79172 1.86497 0.063311845 0.27060972 1.27971052 0.55667608 cgl2441928 CCR1 1230 1.86474 0.063344878 0.270631173 1.29069905 0.55990319 cg00434413 ARD1A 8260 -1.86456 0.063370068 0.270631173 0.7587913 0.54765026 cg06384026 PPFIA1 8500 1.86447 0.063381851 0.270631173 1.28347955 0.57871117 cg21046940 DAP 1611 1.86445 0.063385098 0.270631173 1.29203842 0.56060912 cg25287375 OSTF1 26578 1.86443 0.063387625 0.270631173 1.27753688 0.56691206 cgl3797031 NIPSNAPl 8508 -1.86419 0.063421856 0.270671751 0.77301128 0.56585317 cg02995130 RSN 6249 1.86417 0.063425438 0.270671751 1.28596965 0.56565147 eg 10878896 CS 1431 1.86394 0.063457453 0.270743668 1.31072488 0.56302945 cgl0569616 POT1 25913 -1.86384 0.063470606 0.270743668 0.77966321 0.57175272
cg22325715 CNTD 124817 1.86363 0.063500905 0.270812504 1.29341351 0.56857604 cg00013618 IGL@ 3535 -1.86334 0.063542348 0.270895329 0.7732585 0.58082896 cgl7832674 CALM3 808 1.86329 0.063548658 0.270895329 1.27134053 0.56923155 cg04824716 CCHCR1 54535 1.86313 0.063571545 0.270932496 1.27442146 0.55007059 eg 11560403 TMEM81 388730 -1.86295 0.06359686 0.270979994 0.77465378 0.56842477 cg07443748 CESK1 150160 -1.86272 0.063630021 0.270980616 0.77654808 0.57230738 eg 18565479 DISCI 27185 1.86263 0.06364278 0.270980616 1.2869097 0.56403792 cgl8971671 TULP2 7288 -1.86248 0.063663217 0.270980616 0.77433394 0.55354982 cgl9235307 MBD4 8930 1.86246 0.063666528 0.270980616 1.30175756 0.55430617 eg 10246520 OLFM4 10562 -1.8623 0.063689079 0.270980616 0.77399407 0.55617184 cgl5316334 CEACAM5 1048 1.86229 0.063690201 0.270980616 1.28321523 0.5498689 eg 10468369 DDX19B 11269 1.86225 0.063696199 0.270980616 1.27754795 0.58955224 cg27313662 PPA2 27068 1.86174 0.063767415 0.271126146 1.28611803 0.56106293 cg04062907 ANAPC7 51434 1.86167 0.063778031 0.271126146 1.29458148 0.56489512 cgl9623751 CEACAM7 1087 -1.86152 0.063799184 0.271126146 0.77594891 0.54850746 cg23667407 LOC51255 51255 1.86151 0.06379999 0.271126146 1.28379219 0.5357503 cg25766774 ZDHHC3 51304 -1.8614 0.06381569 0.271126146 0.76610276 0.5532977 cgl9744131 PRUNE 58497 1.86138 0.063819424 0.271126146 1.28410034 0.56565147 cgl4610746 CLN6 54982 1.86121 0.063842511 0.271126146 1.28971875 0.55526422 cgl5361231 GLRX2 51022 1.86119 0.06384558 0.271126146 1.29811078 0.55960065 cgl9703610 DSCAML1 57453 -1.8611 0.06385801 0.271126146 0.77489723 0.57503025 cgl3368786 ACSS2 55902 1.86093 0.063882976 0.271164861 1.28708181 0.56701291 cg05890019 WDFY3 23001 1.86075 0.063908449 0.271164861 1.2862402 0.57024002 cg22309826 COPS3 8533 -1.86058 0.063932633 0.271164861 0.77781047 0.56081081 cg09538287 CTNNA3 29119 -1.86055 0.06393679 0.271164861 0.78197847 0.55065046 cg00532890 PBX1 5087 1.86054 0.063938029 0.271164861 1.28703167 0.5717023 cgl0275770 ICAM2 3384 1.8603 0.063972747 0.271210459 1.29464623 0.56665994 cgl0823546 MAK10 60560 1.86025 0.063979646 0.271210459 1.28939621 0.56726503 cg23363832 RBP1 5947 1.86016 0.063991328 0.271210459 1.28621333 0.57921541 cg08735298 Clorfl22 127687 1.85995 0.064022088 0.271280703 1.29615743 0.57437475 cg07947016 KLK2 3817 -1.85975 0.064050694 0.271341793 0.78160449 0.56787011 cg09726469 MCL1 4170 -1.8594 0.064100225 0.271491478 0.77790939 0.54018758 eg 14425294 GUCY2D 3000 1.85912 0.064139855 0.271532126 1.27792922 0.55465914 cg21521452 AGA 175 1.85905 0.064149578 0.271532126 1.29008189 0.56217225 cg20648463 Gl-A 2717 1.85903 0.06415242 0.271532126 1.28322813 0.55849133 cgl6571399 TLN2 83660 -1.85834 0.064250612 0.271835062 0.76742142 0.57891287 cg02915544 PSMAL 219595 -1.85829 0.064257628 0.271835062 0.77991947 0.5477259 cg06469542 THSD3 145501 1.85821 0.06426917 0.271835062 1.284311 0.56025615 eg 10404950 ALKBH8 91801 1.85813 0.064280853 0.271835062 1.30203754 0.57402178 cg24340657 KRT24 192666 -1.85785 0.064321211 0.271945593 0.77280486 0.5770472 cg20324165 KRT8 3856 -1.85765 0.064348529 0.271984418 0.77915198 0.5479528 cg22243662 ATP6V1C2 245973 1.85758 0.06435884 0.271984418 1.27637267 0.57205526
cg03087937 MUC15 143662 -1.85737 0.06438974 0.272006543 0.77382507 0.55581888 cg22957381 KCND3 3752 -1.85735 0.064392523 0.272006543 0.77144079 0.54220452 cg08077673 MEST 4232 1.85704 0.06443606 0.27213034 1.28257264 0.54043969 cgl8343862 XLKD1 10894 -1.8566 0.064498703 0.272334753 0.77625453 0.56676079 cg25159668 AADACL2 344752 -1.85648 0.064516816 0.272351094 0.77606792 0.57588746 cg04743650 VCAM1 7412 -1.85629 0.064543315 0.272359336 0.78188923 0.55909641 cg25027501 GSTM3 2947 -1.85626 0.064547253 0.272359336 0.77236119 0.54467527 cg07427065 MEST 4232 1.85591 0.064597441 0.272484307 1.2970025 0.5794171 cg25221625 CRYBB3 1417 -1.85586 0.064605369 0.272484307 0.76921828 0.55839048 cg23322112 ABCC13 150000 -1.85563 0.064637613 0.272554581 0.77072738 0.56761799 cg08567916 SPRYD3 84926 -1.85543 0.064665962 0.272554581 0.77977684 0.56348326 cg20357806 PPBP 5473 -1.8554 0.064670662 0.272554581 0.76831718 0.56968536 cg06940107 C21orfl00 118421 -1.85534 0.064679042 0.272554581 0.77373752 0.58148447 cg07642638 CHGB 1114 -1.85464 0.064779095 0.272817386 0.77579238 0.57039129 cg20367072 ETFB 2109 1.85459 0.06478693 0.272817386 1.29090869 0.57528237 cg02867079 KIAA1822 84439 1.85454 0.064793647 0.272817386 1.28875051 0.56539936 cg01657408 FU31951 153830 1.85439 0.064815772 0.272817386 1.2955447 0.56736587 cg02876062 FAM 107B 83641 -1.85407 0.064862233 0.272817386 0.76653141 0.56928197 cgl4317651 COPS2 9318 1.85403 0.064867293 0.272817386 1.30933938 0.57225696 cg24070292 TPM2 7169 1.85382 0.064898115 0.272817386 1.28190661 0.56812223 cg00079056 SPINK4 27290 -1.85381 0.064898753 0.272817386 0.77066227 0.57815652 cg02564733 ADAMTS15 170689 1.85374 0.06490843 0.272817386 1.28673526 0.56192013 cg04336379 LOC389458 389458 1.85371 0.06491379 0.272817386 1.27942872 0.57185357 cg05399697 LOC400986 400986 -1.85368 0.064917206 0.272817386 0.77263114 0.5652733 cgl5722679 SIRPB2 55423 1.85363 0.064924699 0.272817386 1.29437201 0.55468435 cg26127679 RAD51AP1 10635 1.8535 0.064943359 0.272817386 1.29272879 0.55813836 cg24204740 RWDD2 112611 1.8535 0.064943399 0.272817386 1.28886399 0.57175272 cg20770311 SMPD1 6609 -1.85342 0.064955405 0.272817386 0.77493335 0.56217225 cg04541293 PTPRT 11122 -1.85297 0.06501928 0.2730257 0.77611926 0.55985276 cgl l712199 TAIP-2 80034 -1.85257 0.065077522 0.273210276 0.77868669 0.57518153 cgl9914751 QARS 5859 1.85234 0.065110645 0.273289336 1.28674197 0.54149859 cgl3109289 C1GALT1 56913 -1.8522 0.065130291 0.273311807 0.77772895 0.54976805 cg05603623 TIMM44 10469 1.85197 0.065163365 0.273344129 1.29228687 0.56257564 cg20790540 PTCRA 171558 -1.85191 0.065171709 0.273344129 0.77642192 0.56585317 cg08871016 HSF2BP 11077 1.85185 0.065180876 0.273344129 1.29267283 0.57008875 cg05976325 LOC284912 284912 -1.85165 0.06520949 0.273404169 0.77027336 0.57296289 cg08400120 PRKCI 5584 1.85096 0.065309056 0.273614895 1.28614491 0.55239008 cg25605408 FU40142 400073 -1.85094 0.065312897 0.273614895 0.77290521 0.55531464 eg 16540768 TMEM56 148534 1.85092 0.065314817 0.273614895 1.28975428 0.56348326 cg26683023 ZNF678 339500 -1.85091 0.065316983 0.273614895 0.77975991 0.56267648 cg02611419 KCNK17 89822 1.8506 0.065361825 0.273742773 1.29798637 0.56504639 eg 11854007 RP11- 317716 1.85026 0.065410753 0.273828443 1.29005931 0.56353368
49G10.8
cg22101147 TMEMl lO 375346 1.85021 0.065417564 0.273828443 1.30403205 0.55455829 cg05494459 FTSJ1 24140 -1.85016 0.065425238 0.273828443 0.76835818 0.55551634 cg21022435 NFRKB 4798 -1.84999 0.065449457 0.273869866 0.77284428 0.56918112 cg24990612 PDGFB 5155 1.84962 0.065503231 0.274034916 1.28219998 0.55622227 cg01785060 ZDHHC21 340481 1.84931 0.065547475 0.274084155 1.29005212 0.56413877 cgl5534366 CDH4 1002 -1.84928 0.065552526 0.274084155 0.77958184 0.56494554 cgl7414107 GNAS 2778 1.84924 0.065557999 0.274084155 1.29018238 0.57366882 cg20195812 STAT4 6775 1.84914 0.065572976 0.274086848 1.29480753 0.56948366 cgl5683488 ZFYVE9 9372 1.84893 0.065602772 0.274148684 1.28558571 0.57402178 cg08505473 PRIMA1 145270 -1.84883 0.065617293 0.274148684 0.77825191 0.54810407 cgl3342558 TECTB 6975 -1.84874 0.065630778 0.274148684 0.77914465 0.5800474 cgl2118011 S0AT1 6646 1.84832 0.065691533 0.27434254 1.28541316 0.55919726 cg23214267 EYA2 2139 1.8481 0.065724056 0.274418433 1.29018114 0.56736587 cgl4217534 K-ALPHA-1 10376 1.84765 0.065788574 0.274564742 1.28484176 0.55960065 cg09791681 TMC03 55002 1.84756 0.065801777 0.274564742 1.30542644 0.54926382 cg02807450 MTMR2 8898 1.84756 0.065802171 0.274564742 1.29380015 0.55231444 cg21803417 MTRR 4552 1.84737 0.065829835 0.274620249 1.28965488 0.56595401 cgl7352004 C14orf29 145447 -1.84701 0.065882461 0.274727449 0.77632981 0.56020573 cgl5587603 RPS27A 6233 1.84692 0.065894516 0.274727449 1.29670601 0.56333199 cg07594933 CCDC77 84318 -1.84688 0.065900404 0.274727449 0.7747908 0.57417305 cgl7703554 WDR21C 138009 -1.8468 0.065912997 0.274727449 0.7668555 0.55823921 cgl9830147 LSS 4047 1.84665 0.065934619 0.274757683 1.27579013 0.56161759 cg23154064 C3orf63 23272 -1.84649 0.065958098 0.274795643 0.77187691 0.56126462 cg23269489 BC0RL1 63035 -1.84623 0.065995225 0.274879448 0.76937938 0.5839048 cg05119218 HK3 3101 -1.84615 0.066006962 0.274879448 0.78010907 0.56277733 cg08285151 HDAC9 9734 1.84579 0.066060233 0.275041393 1.28799846 0.54129689 cg08427977 C10orf72 196740 1.84553 0.066097053 0.275134789 1.28967551 0.55657523 cgl4896516 CRHR2 1395 -1.84529 0.066131991 0.275218849 0.77978843 0.56202098 cg02712165 C17orf76 388341 -1.84512 0.066157965 0.275218849 0.78500774 0.56297902 cgl l893236 PRMT7 54496 1.8451 0.066160738 0.275218849 1.28263346 0.55677693 cg08397758 C10orf33 84795 1.84494 0.066182799 0.275218849 1.27953768 0.54407019 cgl3662243 PCMT1 5110 -1.84461 0.066231241 0.275218849 0.77097432 0.54497781 cgl9248557 HLA-DRA 3122 1.84448 0.066250121 0.275218849 1.30196138 0.55995361 cgl5233681 IL1R1 3554 -1.84447 0.066252268 0.275218849 0.77799591 0.57371924 cgl9819891 MYST1 84148 1.84427 0.066282036 0.275218849 1.29065562 0.55183542 cg23489497 ATPBD1B 54707 1.84426 0.066283262 0.275218849 1.28693583 0.53620412 cg21785536 AER61 285203 1.8442 0.066291283 0.275218849 1.29276601 0.57603873 eg 16440909 CXorf6 10046 1.84415 0.066298914 0.275218849 1.27200996 0.5453812 cg06859828 TNFRSF25 8718 -1.84412 0.066302687 0.275218849 0.77003785 0.55682735 cg20615951 Clorf71 163882 -1.84406 0.066312487 0.275218849 0.77601033 0.56736587 cgl6993794 SLC2A11 66035 1.84394 0.06632925 0.275218849 1.29315674 0.57669423
eg 19954000 FGF1 2246 -1.84385 0.06634218 0.275218849 0.76561248 0.55239008 cg l0798171 ICA1 3382 1.84382 0.06634752 0.275218849 1.28325665 0.56413877 cgl5957394 AFAP 60312 -1.84345 0.066401225 0.275381886 0.78400103 0.55007059 cgl2148581 RPL14 9045 1.84313 0.066447771 0.275513365 1.29418663 0.57371924 cg25215340 CDKN1C 1028 1.84304 0.066461743 0.275513365 1.28249372 0.54412061 cgl5522719 GLS 2744 1.84273 0.066507202 0.275642062 1.29343748 0.56544978 cg09343150 MEN1 4221 -1.8426 0.066525949 0.275660016 0.77166447 0.55027229 cg04748010 POU6F2 11281 -1.84245 0.06654819 0.275670133 0.77334743 0.55687777 cgl9731122 MY01C 4641 -1.84239 0.066557222 0.275670133 0.77633421 0.55944938 cgl6456919 LRRN5 10446 -1.84209 0.066600639 0.275692706 0.77445352 0.56151674 cg27651218 COX8C 341947 -1.84205 0.066605952 0.275692706 0.78079022 0.5331787 cgl5591837 PPIL1 51645 1.84162 0.066669693 0.275692706 1.28400574 0.54850746 eg 14046365 NMI 9111 1.84161 0.066671697 0.275692706 1.28927872 0.57150061 cg00560119 STXBP1 6812 1.84151 0.066686395 0.275692706 1.29431354 0.57593788 cgl2535715 HTRA4 203100 1.84145 0.066694952 0.275692706 1.29624187 0.56923155 cg03569637 FAM 113B 91523 1.84116 0.0667366 0.275692706 1.28539748 0.57054256 cgl4353201 ALDH3B2 222 -1.84114 0.066740407 0.275692706 0.77667838 0.57613957 cgl6617137 SIGLEC6 946 -1.84114 0.066740765 0.275692706 0.78087432 0.5697862 cgl l005091 HNRPA1 3178 1.84111 0.066744085 0.275692706 1.29668828 0.56671037 cg21655693 SYMPK 8189 1.84102 0.066757954 0.275692706 1.29305139 0.56605486 eg 10784090 CLDN18 51208 -1.841 0.066760921 0.275692706 0.77707716 0.55390278 cg01169726 DLX5 1749 -1.84098 0.066763801 0.275692706 0.77696743 0.54860831 cgl8370979 C5orf21 83989 -1.84098 0.066764508 0.275692706 0.78261005 0.54946551 cg05919661 LMBR1L 55716 1.84059 0.06682144 0.27577484 1.27955279 0.55077652 cg22048492 HTATIP 10524 1.84055 0.066826537 0.27577484 1.28219941 0.56252521 cg08324796 GPKOW 27238 1.84047 0.066838661 0.27577484 1.28211554 0.55909641 cg05248781 LCE5A 254910 -1.84045 0.066842083 0.27577484 0.77825601 0.56988705 cgl9147570 MDH1 4190 1.84019 0.066880004 0.275871774 1.28240486 0.56716418 cg01086868 AR 367 -1.84009 0.066894777 0.275873204 0.77288721 0.55012102 cg25797366 HSPA2 3306 -1.83998 0.066911619 0.275883161 0.77535324 0.56136547 cg04270835 SLC17A6 57084 1.83974 0.06694669 0.275968264 1.28088868 0.57175272 eg 14784653 C10orf30 222389 -1.83948 0.066985073 0.276004041 0.77844778 0.54190198 cg24905739 FBXW8 26259 -1.83936 0.067002384 0.276004041 0.78121518 0.56166801 cg22654935 LOC126248 126248 -1.83933 0.067007215 0.276004041 0.77464746 0.55834006 cg02679745 FUT7 2529 1.83929 0.067013102 0.276004041 1.27602439 0.56817265 cgl3652653 TMEM33 55161 1.839 0.06705528 0.276075343 1.29240687 0.57089552 cg07685869 KIFC3 3801 1.83897 0.067059288 0.276075343 1.28173101 0.56045785 cg20011974 EIF2B2 8892 1.83877 0.06708908 0.276088828 1.28451494 0.56318072 cg27019278 EMCN 51705 1.83869 0.06710133 0.276088828 1.28351186 0.5717023 cgl7948627 PSMB2 5690 1.83866 0.067105876 0.276088828 1.28838482 0.56499597 cgl9234509 BCAS2 10286 1.83835 0.067151147 0.27610672 1.28420182 0.57402178 cg21003606 CALN1 83698 -1.83835 0.067151766 0.27610672 0.77900657 0.56010488
cg05508558 CR2 1380 1.83833 0.067155115 0.27610672 1.27701854 0.56534893 cg01716083 ZNRD1 30834 1.83824 0.067167979 0.27610672 1.28606835 0.54659137 cg23894539 STARD3 10948 1.83798 0.067205731 0.276202535 1.27989434 0.54654094 cg08315770 KCNK17 89822 1.83766 0.067253601 0.276261732 1.27909364 0.53035498 eg 10990993 MLH1 4292 -1.83764 0.067256367 0.276261732 0.78015844 0.556071 eg 14345676 HRH2 3274 -1.83759 0.067263475 0.276261732 0.76379566 0.5558693 cg23326301 ADAM30 11085 -1.83709 0.067337322 0.276505646 0.7742978 0.55793667 cg00930078 FBX028 23219 1.83697 0.067355943 0.276506239 1.27452026 0.5699879 cg07436807 ACTA2 59 -1.8369 0.067366385 0.276506239 0.77722921 0.57200484 cg06384491 SPIN2 54466 1.83666 0.067402284 0.276594219 1.28257249 0.55965107 cg23679085 AP2M1 1173 1.83644 0.067433644 0.276663539 1.28185969 0.55662566 cg21858376 ITPR1 3708 1.8363 0.067455113 0.276692256 1.27832397 0.5753328 cgl2955127 ATP5F1 515 -1.8361 0.067484379 0.276752938 0.77757036 0.54805365 cg04837322 ROD1 9991 1.83562 0.06755637 0.276982438 1.28801557 0.56101251 cg26287783 C6orf64 55776 1.83547 0.06757766 0.276982438 1.27820439 0.55410448 cg26194560 GTF3C3 9330 1.83534 0.067597918 0.276982438 1.28806397 0.54649052 cg00960702 CCDC9 26093 1.83533 0.067598278 0.276982438 1.28481701 0.56413877 cg09282338 NXT1 29107 1.83472 0.067690103 0.277240616 1.27884887 0.57049213 cgl5700739 HOXC5 3222 1.83472 0.067690283 0.277240616 1.28302684 0.58264421 cg26168975 Clorf80 64853 1.83418 0.067769785 0.277449191 1.29733313 0.56716418 cg27485235 CLC 2 1181 1.83418 0.067770225 0.277449191 1.29669817 0.55939895 cgl5860839 SNAPC1 6617 1.83395 0.067804691 0.277530876 1.28201486 0.5751311 cg04809787 CHRNB1 1140 1.83358 0.067859961 0.277697666 1.27734681 0.52964905 cg20131968 CCDC47 57003 -1.83342 0.067883615 0.277735027 0.77517733 0.55188584 cg04726446 MGC16372 92749 1.8333 0.067901584 0.277749119 1.28122733 0.55879387 cg20233029 B4GALNT2 124872 1.8332 0.067916203 0.277749509 1.27904475 0.55400363 cgl3173909 UGCGL1 56886 1.83272 0.067988449 0.277967512 1.27766505 0.55299516 cgl0169812 CD38 952 -1.83253 0.068015761 0.277967512 0.77566685 0.57719847 cgl2052765 CHAT 1103 1.8325 0.068019962 0.277967512 1.28460159 0.57119806 eg 18750960 HOXD4 3233 1.83245 0.068027654 0.277967512 1.28721958 0.57175272 cgl l219178 OSBPL5 114879 -1.83215 0.068072485 0.278033614 0.77249487 0.57165188 cg00567479 FARP2 9855 1.83215 0.068072909 0.278033614 1.27752136 0.55934853 eg 13784557 HCP5 10866 1.83172 0.068137727 0.278217658 1.28027852 0.56862646 cg20627916 ESR1 2099 1.83152 0.068166575 0.278217658 1.28907218 0.55339855 cg02479196 Mar-07 64844 1.83151 0.068167933 0.278217658 1.28940816 0.57190399 cgl7867194 SLC30A6 55676 1.83144 0.068178362 0.278217658 1.27993998 0.56247479 cg04528819 KLF14 136259 1.83136 0.068190715 0.278217658 1.28545984 0.57745059 cg03520136 UPP2 151531 -1.83121 0.068214017 0.278253366 0.78093197 0.55632311 cg21300561 K-ALPHA-1 10376 1.83097 0.068249778 0.278339863 1.27405264 0.58163574 cgl5552238 EMR3 84658 1.83018 0.068367928 0.278382309 1.28701043 0.56116378 cg26112353 BMP2K 55589 1.83013 0.068374997 0.278382309 1.28337385 0.57155103 cg26706003 AVPR1A 552 -1.83012 0.068376329 0.278382309 0.78016083 0.56986184
cg23681213 PNMA1 9240 -1.83009 0.068381065 0.278382309 0.78104288 0.56908027 cgl ll02782 ISYNA1 51477 1 .83002 0.068391315 0.278382309 1.278956 0.55597015 cg20638426 ZNF14 7561 1 .82997 0.06839965 0.278382309 1.27972504 0.56504639 cg02713563 TRAPPC6A 79090 1 .82994 0.068403565 0.278382309 1.28797857 0.54936466 cgl l318251 BAALC 79870 1 .82984 0.068419309 0.278382309 1.2842172 0.5892497 cg25017304 ARHGEFl l 9826 1 .82952 0.068467262 0.278382309 1.27754359 0.56171844 cg26414720 MAGEA1 4100 -1 .82944 0.068479285 0.278382309 0.77712335 0.560357 cgl5658426 MGC39633 153733 1 .82924 0.068508178 0.278382309 1.28328286 0.54417104 cg08884343 F0XP3 50943 -1 .82913 0.068525936 0.278382309 0.78005534 0.56983663 cg07786760 DCHS2 54798 1 .82906 0.068536196 0.278382309 1.27535167 0.56479427 cg00145348 APEX2 27301 1 .82895 0.068552922 0.278382309 1.27635566 0.54598629 cg04872689 PLEK 5341 1 .82892 0.068557423 0.278382309 1.27663413 0.59348528 cg06084735 ENY2 56943 1 .82891 0.068558109 0.278382309 1.2897662 0.55420533 cgl7272843 KCTD14 65987 1 .82889 0.068562039 0.278382309 1.27421812 0.56192013 cg21690892 GUCA1B 2979 -1 .82875 0.068582107 0.278382309 0.78825437 0.56923155 cg07195282 ZNF563 147837 1 .82872 0.068586733 0.278382309 1.27192224 0.55042356 cgl7682309 STX7 8417 1 .82863 0.068600154 0.278382309 1.2914136 0.56862646 cg01887353 ZNF41 7592 -1 .82855 0.068612562 0.278382309 0.78126231 0.5462384 cg01437411 AT 1 1822 1 .82848 0.068623476 0.278382309 1.30004811 0.56585317 cg02626929 PAQR4 124222 1 .82847 0.068624052 0.278382309 1.28028352 0.55304558 cg21377793 TSPAN3 10099 -1 .82841 0.068633434 0.278382309 0.78074341 0.54991932 cg08530414 CD44 960 1 .82839 0.068637318 0.278382309 1.27830633 0.56660952 cg07401901 DAAM1 23002 1 .82828 0.068653345 0.278382309 1.2834354 0.55193627 cg08711724 N0C3L 64318 1.8282 0.068665642 0.278382309 1.28518301 0.57997176 cgl9177941 ALDH1A3 220 1 .82815 0.068672872 0.278382309 1.27399638 0.55566761 cgl9895197 C17orf37 84299 1 .82809 0.068682353 0.278382309 1.27768407 0.54341468 cg01144286 C20orfl03 24141 1 .82779 0.06872714 0.278399825 1.27175608 0.56908027 cgl6029760 OSTbeta 123264 1 .82776 0.068731414 0.278399825 1.28042945 0.57356797 cg02511532 TAF2 6873 1 .82768 0.068744287 0.278399825 1.28161137 0.55960065 cgl6998872 GYPE 2996 -1 .82767 0.068744909 0.278399825 0.77247715 0.55294474 cgl3665184 DUS2L 54920 1 .82698 0.068848638 0.278728441 1.27367392 0.56691206 cg27365426 ARHGAP15 55843 1 .82686 0.068866522 0.278728441 1.27698334 0.56192013 cg22812892 IDE 3416 1 .82684 0.0688707 0.278728441 1.27635416 0.55934853 cgl8587271 GPT2 84706 1 .82675 0.068884356 0.278728441 1.28364758 0.58198871 cg05019661 ADK 132 1 .82625 0.06895914 0.278972015 1.28827744 0.57200484 cg04228042 ART4 420 -1 .82613 0.068977505 0.278987288 0.77328747 0.55763413 cg26509022 ALDH1A3 220 1 .82568 0.069045425 0.279201051 1.27405905 0.56665994 cg02198582 TSC2 7249 -1 .82536 0.069094258 0.279201051 0.76918028 0.56529851 cgl0530733 GPR173 54328 -1 .82535 0.069096037 0.279201051 0.78417717 0.55551634 eg 16546489 HSD17B1 3292 -1 .82533 0.069098966 0.279201051 0.77975693 0.5759883 cgl9157069 WDR23 80344 1.8253 0.069103358 0.279201051 1.27679111 0.56373538 cg03718026 RPS20 6224 1.82464 0.069203518 0.279546667 1.28573217 0.56020573
cgl l939047 NARG2 79664 1.82447 0.069228898 0.279590129 1.28134557 0.56761799 cg01665633 NDNL2 56160 1.8243 0.069255078 0.279625001 1.28015423 0.56797096 cg25993718 CBLN4 140689 1.82421 0.069267979 0.279625001 1.272397 0.55168415 cgl6307860 Clorf80 64853 1.82412 0.0692814 0.279625001 1.28872793 0.57538322 cg02029926 CXCL1 2919 1.82392 0.069312799 0.279647226 1.28483222 0.54543163 cgl6367232 UTP14A 10813 1.82389 0.069316154 0.279647226 1.27855695 0.56070996 cg23018891 BCAS2 10286 1.82368 0.06934896 0.279720565 1.28146619 0.57155103 cg25835225 ZNF350 59348 1.82315 0.069429314 0.279912327 1.27575011 0.5594998 cg09529667 SSBP4 170463 1.8231 0.06943704 0.279912327 1.27804875 0.55879387 cgl5528736 FCGRT 2217 1.823 0.069451668 0.279912327 1.29385744 0.54684349 cg05420896 DCC 1630 1.82286 0.069472263 0.279912327 1.28831139 0.56479427 cg27419217 TROAP 10024 1.82268 0.069499959 0.279912327 1.28071985 0.56252521 cg25229172 CCDC38 120935 1.82265 0.069505005 0.279912327 1.27807983 0.56812223 cgl0887392 CTDSP1 58190 -1.82264 0.069506008 0.279912327 0.78135008 0.55052441 cgl0377764 RAD52 5893 -1.82253 0.069523514 0.279912327 0.77448389 0.55102864 cgl9259146 RPS6KA1 6195 1.8224 0.069543056 0.279912327 1.27963163 0.55067568 cgl9836283 ITGA11 22801 1.82237 0.06954801 0.279912327 1.28195617 0.56126462 cg26516759 BMP7 655 1.8223 0.069557515 0.279912327 1.27460279 0.5436668 cg06641503 ARIH2 10425 -1.82194 0.069612389 0.280019121 0.7798077 0.55117991 cg26209676 ZNF581 51545 1.82194 0.069613339 0.280019121 1.26863758 0.56640783 cg00755709 BAAT 570 -1.82176 0.069640497 0.280069451 0.77433401 0.55798709 cg27305662 C6orfl5 29113 -1.82161 0.069663648 0.280091432 0.77871842 0.55314643 cgl4913610 KLRG1 10219 1.82151 0.069678835 0.280091432 1.29076246 0.54351553 cg23680518 SBSN 374897 -1.82141 0.069693202 0.280091432 0.78021942 0.58511497 cg02385474 PCNXL2 80003 -1.82134 0.06970455 0.280091432 0.7772177 0.55687777 cgl ll99399 LTBP1 4052 1.82101 0.069754031 0.280231375 1.27331498 0.55380194 cg22458082 OTUD7 161725 -1.82065 0.069809692 0.280396084 0.78200309 0.54981848 cg20288630 PDE5A 8654 1.82046 0.069838718 0.28045376 1.27639706 0.56328157 cg04968473 CYP1A2 1544 -1.82033 0.069857827 0.280458216 0.78043918 0.54588544 cg07484827 CHRNAIO 57053 -1.8202 0.069878844 0.280458216 0.77924374 0.55228923 cg08753553 DEFB106A 245909 -1.82016 0.069883825 0.280458216 0.77638165 0.5663574 cg00167504 BLVRA 644 1.81987 0.069928489 0.280568423 1.27913176 0.54432231 eg 14540297 LOC339524 339524 1.81979 0.06994063 0.280568423 1.28385118 0.56131505 cgl l959821 TBRG4 9238 1.81959 0.069971758 0.280634423 1.27607263 0.5552138 cgl8715299 AMHR2 269 -1.81928 0.070018304 0.280762221 0.77472619 0.54255748 cgl3823791 C0PS3 8533 1.81915 0.070038321 0.280783606 1.29511193 0.57982049 cg05444024 FUT6 2528 1.81891 0.070074942 0.280871538 1.27977878 0.54689391 cg21614231 BAG1 573 -1.81861 0.07012101 0.280970927 0.77205165 0.54971763 cg24910675 ENG 2022 1.81853 0.070133797 0.280970927 1.27367355 0.56615571 cgl2575181 PIGH 5283 -1.81843 0.070149049 0.280970927 0.77520616 0.54830577 cg26789453 TMEM116 89894 1.81836 0.070159924 0.280970927 1.28829106 0.5759883 cg00563926 TGFBR3 7049 1.81827 0.070173203 0.280970927 1.28104137 0.55496168
cgl8389062 MAN1A2 10905 1.81803 0.070210282 0.281008901 1.27343991 0.55904599 eg 19740287 MOSPD2 158747 1.81802 0.070212077 0.281008901 1.27127298 0.5534994 cgl8692273 TNNT2 7139 -1.81772 0.070258355 0.28113528 0.78254592 0.57699677 cgl9713196 LAD1 3898 -1.81735 0.07031509 0.281303438 0.78251644 0.54886043 cg09001777 FUT3 2525 1.8171 0.070353516 0.281398296 1.27761141 0.57008875 cg07052880 ATP6V1B1 525 -1.81694 0.070377326 0.281401767 0.77357425 0.5674163 cg24660086 RGR 5995 -1.81679 0.070400826 0.281401767 0.78336293 0.56933239 cg02611863 L3MBTL 26013 -1.81675 0.070406794 0.281401767 0.78563709 0.55944938 cg02117021 OR2H1 26716 -1.81669 0.070416618 0.281401767 0.77802574 0.57039129 cgl6338822 TPX2 22974 1.81653 0.070441278 0.281401767 1.29193964 0.55531464 cg24928687 EPHX1 2052 -1.81647 0.070450083 0.281401767 0.77469142 0.57205526 cg00406188 LCE2C 353140 -1.81642 0.070457391 0.281401767 0.77866723 0.53474183 cg07678643 LOCI 13444 113444 1.81592 0.070534619 0.281651385 1.27840164 0.57180315 cgl6173067 SDCBP2 27111 1.81572 0.070565194 0.281674362 1.27459124 0.56993748 cgl2793610 TRIM 2 23321 -1.81563 0.07057966 0.281674362 0.77984878 0.5736184 cg03399971 INHBC 3626 -1.81559 0.070584562 0.281674362 0.7836016 0.58211476 cg09980622 BO LAI 51027 1.81544 0.070608695 0.281711879 1.27406105 0.55178499 cg24417499 HPCA 3208 1.81522 0.070641712 0.281757167 1.27997736 0.59318274 cg23248452 TAS2R1 50834 -1.81507 0.070664712 0.281757167 0.78412249 0.53080879 cg26164184 FCN2 2220 -1.81494 0.070685687 0.281757167 0.78652199 0.56469343 cg03660451 RECQL5 9400 -1.81491 0.070689647 0.281757167 0.78274369 0.55486083 cg04612566 C8orf31 286122 -1.81489 0.070693716 0.281757167 0.78752374 0.5575837 cg22978941 UNG 7374 1.81468 0.070725297 0.281824296 1.27465436 0.54381807 cg03382797 C9orf98 158067 1.81455 0.070746174 0.281848756 1.27546957 0.54699476 cg24822446 ZFAND3 60685 -1.81404 0.070823971 0.281935534 0.78937857 0.5639875 cgl3903548 GABRR2 2570 -1.81398 0.070834065 0.281935534 0.77626552 0.55657523 cgl5781316 SHFM1 7979 1.81385 0.070853025 0.281935534 1.29551072 0.57034086 cg22344641 TRUB2 26995 1.81363 0.070888185 0.281935534 1.28455672 0.59857806 cgl9029220 UGP2 7360 1.81355 0.070900233 0.281935534 1.27291338 0.55264219 cg20587968 UCN3 114131 -1.81354 0.070902063 0.281935534 0.77702637 0.56423961 cgl6029636 SLC39A1 27173 1.8135 0.070908054 0.281935534 1.26952939 0.56600444 cg01354473 HOXA9 3205 -1.8134 0.070922784 0.281935534 0.78655132 0.55632311 cgl5971836 KIAA1212 55704 1.81328 0.07094208 0.281935534 1.27994577 0.56126462 cgl0031651 LRRC2 79442 -1.8131 0.070968856 0.281935534 0.77487152 0.56156716 cg25782563 MED9 55090 1.81308 0.070972005 0.281935534 1.28573149 0.57356797 cg25886875 PSMC4 5704 1.81302 0.070982078 0.281935534 1.28483885 0.56489512 cg07643942 LACRT 90070 -1.81301 0.070982635 0.281935534 0.78583999 0.55405405 cg l9382175 PDE6A 5145 -1.813 0.070984217 0.281935534 0.77688354 0.56645825 cg24088229 SMU1 55234 1.81277 0.071020105 0.281935534 1.28427292 0.55425575 cg21602160 AOC3 8639 -1.81276 0.071021404 0.281935534 0.78534994 0.55576846 cgl4870461 AER61 285203 1.81276 0.071021731 0.281935534 1.27656106 0.5391791 cg00980978 WFDC2 10406 1.8126 0.071046108 0.281935534 1.28044469 0.56439088
cg25913233 SPARC 6678 1.81247 0.071067167 0.281935534 1.2808402 0.54578459 eg 15589156 RAB3IL1 5866 1.8124 0.071078261 0.281935534 1.28201639 0.57276119 cg09971811 CST7 8530 1 81221 0.071106623 0.281935534 1.28130977 0.5629286 cg09560912 NC0A3 8202 1 81221 0.071106969 0.281935534 1.27946187 0.55425575 cg03312426 RRAS 6237 1.8122 0.071109301 0.281935534 1.28161345 0.56857604 cg26116551 ZNF536 9745 -1 81212 0.071121796 0.281935534 0.77680338 0.5699879 cgl9797659 0AZ2 4947 1 81141 0.07123132 0.282231791 1.27494094 0.57230738 cgl6176301 Cllorfl7 56672 1 81104 0.071288593 0.282231791 1.27748291 0.55591973 cg02966329 TTK 7272 1 81101 0.071292949 0.282231791 1.27656848 0.57412263 cg27349746 UBTF 7343 1.811 0.071295368 0.282231791 1.29725957 0.56318072 cgl2609467 DAG1 1605 1 81093 0.071305299 0.282231791 1.28088634 0.57296289 cgl0707565 CUBN 8029 -1 81076 0.071332191 0.282231791 0.77392572 0.58425777 cg24588599 C12orf24 29902 1 81073 0.071336779 0.282231791 1.27146775 0.55970149 cgl0139614 APRT 353 1.8107 0.071341019 0.282231791 1.27976276 0.56494554 cgl l052068 CDC40 51362 1 81061 0.071355534 0.282231791 1.28045779 0.57139976 cg22470827 CHMP2B 25978 1 81061 0.071355609 0.282231791 1.27541221 0.56282775 eg 14944362 PDYN 5173 -1 81059 0.071358877 0.282231791 0.78562679 0.55022186 cg01990334 F0XJ3 22887 1 81009 0.071436594 0.282391336 1.27665906 0.57664381 cgl7824393 PTP 3 5774 -1 81004 0.071444763 0.282391336 0.78627957 0.56371017 cg05912121 TH 7054 1.81 0.071450063 0.282391336 1.27421588 0.56509681 cg03977657 LAMB3 3914 1 80995 0.071458285 0.282391336 1.27905066 0.54734772 cg09134747 ATP2C1 27032 1 80943 0.071538261 0.282608225 1.28000885 0.54770069 cgl9961382 RANGAPl 5905 1 80935 0.071552059 0.282608225 1.27815954 0.56096208 cgl5746620 EMR3 84658 1 80931 0.071557504 0.282608225 1.28523398 0.55486083 cg01027739 D0LPP1 57171 1 80919 0.071576065 0.282623164 1.28219465 0.5657019 cg09229231 DHRS3 9249 1 80902 0.071603325 0.282660857 1.27819645 0.54462485 cg20161179 MSX1 4487 1 80894 0.071615174 0.282660857 1.28085249 0.58037515 cgl4123992 APOE 348 -1 80849 0.071686029 0.282781545 0.78123094 0.58178701 cg03260744 TEKT2 27285 -1 80847 0.071688525 0.282781545 0.77768385 0.53857402 cgl l301598 OASL 8638 1 80844 0.071693203 0.282781545 1.27961487 0.55571803 cg21609430 FAM62A 23344 1 80832 0.071712665 0.282781545 1.27628275 0.56045785 cg05873268 TPSAB1 7177 1 80827 0.071719689 0.282781545 1.27984962 0.56625656 cg08205655 USP18 11274 1 80811 0.071744646 0.282821634 1.28551718 0.55612142 cg24494556 ZNF11B 7558 1 80786 0.071783537 0.282871448 1.27337726 0.54891085 cg22975568 CD74 972 -1 80768 0.071812302 0.282871448 0.76600229 0.56217225 cg08670691 CCDC27 148870 -1 80768 0.071812544 0.282871448 0.77743596 0.54598629 cg26644504 KCNE1L 23630 -1 80753 0.07183469 0.282871448 0.78182418 0.5682735 cgl3728650 GPR175 131601 -1 80727 0.071876737 0.282871448 0.7768993 0.56186971 cg03642357 ADRBK2 157 1 80716 0.071893242 0.282871448 1.27804477 0.56081081 cg04802221 LOC283849 283849 -1 80715 0.071894957 0.282871448 0.78267553 0.57074425 cg06310489 SSX2 6757 -1 80709 0.071903939 0.282871448 0.78188828 0.55440702 cg20189782 MGC27121 408263 -1 80708 0.071905391 0.282871448 0.78025243 0.56348326
cg27376271 CBLN2 147381 1.80701 0.071916358 0.282871448 1.26609897 0.57064341 cg23881725 DLEC1 9940 1.80699 0.071919998 0.282871448 1.29150614 0.55546591 cg09935228 CKS1A 137529 -1.80681 0.071947284 0.282920579 0.76769259 0.56070996 cg09636671 LMOD1 25802 1.80664 0.071974486 0.282954009 1.27453451 0.56287818 cgl4181459 SMAD5 4090 1.80653 0.071991293 0.282954009 1.27610261 0.55556676 cgl0073723 BMPER 168667 1.80642 0.072009341 0.282954009 1.27381018 0.55299516 cgl8936744 AK7 122481 1.80638 0.072014972 0.282954009 1.27324895 0.56096208 eg 16345880 SARS 6301 1.80626 0.072033787 0.282969796 1.2735724 0.57094595 cg26239233 CIITA 4261 1.8059 0.072090608 0.283134841 1.28434273 0.56297902 cg26568669 C6orf57 135154 1.80578 0.072108549 0.28314715 1.27734987 0.55813836 cgl6272420 PNLIPRP2 5408 -1.8055 0.072153514 0.283183949 0.78445828 0.56580274 cg20047732 TTC14 151613 1.80529 0.072185774 0.283183949 1.27572542 0.55233965 cgl3516796 ALG1 56052 1.80525 0.072192921 0.283183949 1.29441585 0.55707947 cgl l793380 C1QTNF6 114904 -1.80518 0.072202957 0.283183949 0.77756928 0.55183542 cg20398399 KLHL6 89857 1.80512 0.072212196 0.283183949 1.28062499 0.55803752 cg24549507 C6orfl45 221749 -1.80503 0.072226555 0.283183949 0.786527 0.54603671 cg27371741 TDGF1 6997 -1.80497 0.07223607 0.283183949 0.78564119 0.57260992 cg25905812 DMRT1 1761 1.80497 0.072236577 0.283183949 1.28260647 0.56373538 cg24046110 LYNX1 66004 1.8048 0.072263351 0.283183949 1.27924305 0.56897943 cgl2465398 PPIL3 53938 1.80478 0.072266006 0.283183949 1.28817064 0.55728116 cg23219720 FU32110 219578 1.80467 0.072283538 0.283194618 1.28705744 0.58198871 cg02299279 UBL7 84993 1.80452 0.072306482 0.283226482 1.27647733 0.54462485 cg07697078 PFDN1 5201 1.80437 0.072329805 0.28325982 1.29177295 0.5665591 cgl7383958 RRAS 6237 -1.80426 0.072347329 0.283270436 0.78220456 0.56620613 cg02764897 KRTAP13-1 140258 -1.80408 0.072375494 0.283322702 0.78065092 0.54427188 cg26538442 FU21736 79984 1.80371 0.072434153 0.283494297 1.29181991 0.56065954 cg04473030 MGMT 4255 -1.80339 0.072484248 0.283616125 0.78052318 0.56908027 cg03479797 CREBL1 1388 1.80332 0.072494943 0.283616125 1.278765 0.55027229 cg01656750 KATNB1 10300 -1.80291 0.072560176 0.283813268 0.78815673 0.5550121 cg07459264 NECAP2 55707 -1.80265 0.072601056 0.283915095 0.78186751 0.53070795 cgl6706631 HIST1H4E 8367 1.80247 0.072630105 0.283970621 1.28362287 0.55420533 cg20424530 IRAK4 51135 1.8023 0.072655718 0.284012695 1.28634778 0.54845704 cg02421543 DR1 1810 1.80218 0.072675164 0.284030648 1.28578432 0.54870916 cgl2569516 TRPS1 7227 1.80205 0.072695759 0.284053087 1.27888236 0.57477814 cgl3966710 FU36116 388666 1.80179 0.07273672 0.284149707 1.2713793 0.55985276 cg26514942 FU30294 130827 -1.80149 0.072783947 0.284149707 0.77942879 0.56272691 cg21860846 ELK1 2002 -1.80141 0.072796903 0.284149707 0.78062898 0.55032271 cg04802801 PPP1R11 6992 -1.80109 0.072846889 0.284149707 0.78244378 0.57866075 cg21087701 GPR119 139760 -1.80107 0.072850011 0.284149707 0.77849248 0.56600444 cg04072323 SKIP 80309 1.80107 0.072850042 0.284149707 1.272526 0.56716418 cgl8368125 TMED6 146456 -1.80101 0.072859526 0.284149707 0.77931676 0.53675877 eg 10244047 BAI3 577 1.80095 0.072868719 0.284149707 1.27664036 0.56534893
cg02078356 TMEM39B 55116 1.80093 0.072872608 0.284149707 1.27847668 0.56696249 cg04335339 ATR L1 26033 1.80085 0.072885248 0.284149707 1.27912993 0.55052441 cg20126106 TAGLN3 29114 1.80079 0.072894471 0.284149707 1.29119817 0.56943324 Cg06444558 PBK 55872 1.80076 0.072898796 0.284149707 1.28321917 0.56192013 cg05301102 STX6 10228 1.80057 0.072929401 0.284159131 1.27794356 0.57119806 cg04775502 C6orfll4 85411 1.80053 0.072936613 0.284159131 1.28683774 0.55314643 cg26054395 MTF2 22823 1.80047 0.072945792 0.284159131 1.28286834 0.56232352 cg04545708 Cl lorfl 64776 1.80026 0.072979202 0.284211161 1.29048549 0.55496168 cg00575744 HLA-DMB 3109 1.80008 0.07300735 0.284211161 1.27640965 0.57177794 cg02547138 RCE1 9986 -1.79995 0.07302762 0.284211161 0.78520446 0.57558491 cg23824815 ZNF333 84449 -1.79982 0.073048652 0.284211161 0.78690222 0.55057483 cgl2989650 ARHGEF15 22899 -1.7998 0.073051257 0.284211161 0.77979187 0.54830577 cg09930017 UBC 7316 1.79975 0.073059391 0.284211161 1.28058382 0.5708451 cgl8055007 DDAH2 23564 1.79973 0.073063335 0.284211161 1.31031094 0.5314643 cgl3299148 COL16A1 1307 1.79958 0.0730863 0.284211161 1.2710612 0.56323114 cg21966410 AR 367 -1.79954 0.07309291 0.284211161 0.78764933 0.55496168 cg08103676 Mar-06 10299 -1.79913 0.07315693 0.28427197 0.7892509 0.55133118 cg02286990 CCDC28B 79140 1.79904 0.073172129 0.28427197 1.28209261 0.5393808 cgl6824731 ILK 3611 1.79901 0.073176608 0.28427197 1.27241065 0.55561718 cg23362667 RIPK5 25778 1.79898 0.073181195 0.28427197 1.27832956 0.54981848 cgl4874121 HSD17B4 3295 1.79897 0.073182876 0.28427197 1.27896497 0.56620613 cg24169822 HOXA4 3201 -1.79878 0.073212604 0.284285652 0.78360935 0.55425575 cgl9372178 TMEM16G 50636 1.79847 0.073262972 0.284285652 1.2714575 0.55148245 cg21808053 DIRAS3 9077 1.79842 0.073269678 0.284285652 1.27517083 0.56413877 cg23127998 FLRT3 23767 1.79833 0.073285016 0.284285652 1.27384481 0.55975192 cgl0716607 TOPORS 10210 1.79826 0.073295184 0.284285652 1.28027759 0.55965107 cg21517055 MGC11271 79173 1.79799 0.073338583 0.284285652 1.26934543 0.54457443 cg26353877 APCS 325 -1.79792 0.073349079 0.284285652 0.77786942 0.56348326 cgl9546781 CCL17 6361 -1.7979 0.073352758 0.284285652 0.78125544 0.55017144 cg06541857 CEP63 80254 1.7979 0.073352881 0.284285652 1.28473073 0.55768455 cg25463135 GBP7 388646 -1.79784 0.073362428 0.284285652 0.78164811 0.55566761 cg03160740 VIPR1 7433 1.79776 0.073374528 0.284285652 1.26929606 0.54588544 cgl2610744 KRT4 3851 -1.79775 0.073376407 0.284285652 0.77777998 0.54891085 cg22998840 TCEAL3 85012 -1.79773 0.073379659 0.284285652 0.78777056 0.55823921 cg01173291 ZSCAN2 54993 1.7976 0.073401383 0.284312214 1.28116109 0.55324728 cgl5955341 GSTM4 2948 1.79749 0.073418717 0.284321766 1.27118672 0.56887858 cgl5377518 ZFHX1B 9839 1.79736 0.073439151 0.284343316 1.2801773 0.53499395 cgl8390025 ELOVL3 83401 1.7972 0.07346428 0.284383032 1.27659366 0.53998588 cg02712845 DPAGT1 1798 1.79697 0.073500369 0.284465148 1.27368215 0.5663574 cg02909790 HIST1 H3G 8355 1.79663 0.073554781 0.28449788 1.27646387 0.58067769 cgl2478185 SCOl 6341 1.79663 0.073554906 0.28449788 1.27889725 0.56267648 cgl0642330 NNAT 4826 1.79655 0.07356725 0.28449788 1.28065387 0.57029044
cgl2542281 PFAAP5 10443 1.79654 0.073568985 0.28449788 1.29579773 0.55198669 cgl3553204 CNKSRl 10256 -1.79645 0.073583213 0.28449788 0.78099831 0.55763413 cg08697242 CA14 23632 -1.79629 0.073609014 0.284540106 0.77564586 0.55264219 cg21302727 TACC2 10579 -1.79605 0.073647346 0.284630745 0.77898553 0.54669222 cg24494008 SMC4L1 10051 1.79596 0.073662279 0.284630936 1.27973691 0.55324728 cg21129531 LRRC4 64101 -1.79583 0.073682124 0.284650097 0.78345257 0.56050827 cg04195127 WFDC1 58189 1.79553 0.073730798 0.2846979 1.2865822 0.56696249 eg 11346450 UGT1A3 54659 -1.79549 0.073736195 0.2846979 0.7831539 0.54926382 cg25136045 SDCCAGIO 10283 1.79548 0.073739161 0.2846979 1.27897813 0.55440702 cg26217633 NLE1 54475 1.7953 0.073766537 0.284746107 1.2795896 0.55995361 cg07959477 CLEC1A 51267 -1.7951 0.073799752 0.284778096 0.78138179 0.55748286 cg06611310 LOC129285 129285 1.7949 0.073831088 0.284778096 1.26740904 0.55395321 cgl9311602 FU10006 55677 1.79483 0.073842103 0.284778096 1.27949485 0.57296289 cg09360083 THYN1 29087 -1.79477 0.073851747 0.284778096 0.77516233 0.54664179 cg02374486 PRF1 5551 -1.79474 0.073856737 0.284778096 0.78501323 0.54578459 cg00495415 SP1 6667 1.79462 0.07387648 0.284778096 1.2687325 0.56988705 cg20492933 MRPL22 29093 1.7944 0.073911605 0.284778096 1.28592453 0.56131505 cgl9110355 WWP2 11060 1.79426 0.073932714 0.284778096 1.27756387 0.55117991 cg09819033 CREBL2 1389 1.79426 0.073933952 0.284778096 1.27519205 0.57351755 cg22543648 GATA1 2623 -1.79425 0.073935009 0.284778096 0.78466659 0.55697862 cgl0377211 SMBP 56889 1.79399 0.073976233 0.284778096 1.26567406 0.55874345 cg23291865 C20orf30 29058 -1.79398 0.073978348 0.284778096 0.78067277 0.56434046 cg05641961 CIB1 10519 -1.79393 0.073986915 0.284778096 0.78051532 0.5507261 cg24073161 ZNF403 79893 1.79388 0.073994276 0.284778096 1.28021045 0.56020573 cgl7417191 CGI-115 51018 1.79385 0.073998204 0.284778096 1.26717549 0.58067769 cg25370441 FU20184 54848 -1.79347 0.074059943 0.284912509 0.7729101 0.56176886 cg25494064 TM0D1 7111 -1.79345 0.074062928 0.284912509 0.78606466 0.55808794 cgl2424817 LAPTM4B 55353 1.79308 0.074121995 0.28495635 1.27165597 0.54991932 cg06493386 TRPA1 8989 -1.79271 0.074181045 0.28495635 0.7814908 0.54951593 cg07818646 FU11712 79621 1.79267 0.07418766 0.28495635 1.27048232 0.56272691 cg08612601 ZBTB12 221527 1.79267 0.074187799 0.28495635 1.26293222 0.55007059 cg23702568 KIAA0261 23063 1.79258 0.074202788 0.28495635 1.27571466 0.55597015 cg07494248 HSPD1 3329 1.79252 0.074212076 0.28495635 1.27045199 0.56348326 cg00094851 KIF3C 3797 -1.79252 0.074212368 0.28495635 0.79099882 0.56842477 cg22539738 KIAA1704 55425 -1.7922 0.074263343 0.28495635 0.77821738 0.57260992 cg25697050 INPP5D 3635 -1.79216 0.074270338 0.28495635 0.78404937 0.54991932 cg02579133 KRTAP10-8 386681 -1.79196 0.074301417 0.28495635 0.77157669 0.57523195 cgl5918284 GABRA2 2555 1.79188 0.074314382 0.28495635 1.28189924 0.56600444 cg25824330 MRPS18A 55168 1.79177 0.074332621 0.28495635 1.26697369 0.56908027 cgl6419345 AC0X1 51 1.79174 0.07433721 0.28495635 1.28744861 0.57497983 cg04326040 VPS53 55275 1.79155 0.074368392 0.28495635 1.28381843 0.55834006 cg09040752 A0C3 8639 1.79145 0.074384541 0.28495635 1.27044672 0.5672146
cg21526212 PTCH 5727 1.79143 0.07438797 0.28495635 1.2711045 0.56202098 cg27212977 DEFA6 1671 -1.79126 0.074413892 0.28495635 0.78185549 0.54886043 cgl5946545 MRPS31 10240 1.79121 0.074421849 0.28495635 1.27770319 0.54038927 cg07155664 RPS14 6208 1.79116 0.074431299 0.28495635 1.2800708 0.56101251 cgl4623518 BAIAP2 10458 -1.79112 0.074436929 0.28495635 0.78958686 0.55269262 cgl9515324 ASH2L 9070 1.7911 0.074440203 0.28495635 1.28101446 0.56313029 cg09263755 CCT6B 10693 1.79107 0.074444633 0.28495635 1.27479502 0.56605486 cg05932936 SERINC3 10955 1.79105 0.074447668 0.28495635 1.27941831 0.55410448 cgl8226566 NEDD9 4739 1.7909 0.074471925 0.28495635 1.2745292 0.54916297 cgl3633560 LRRC32 2615 1.79085 0.074481133 0.28495635 1.27605066 0.57538322 cg22051763 UTP20 27340 1.79074 0.074498836 0.28495635 1.27734366 0.56787011 cgl5113803 RHO 6010 -1.79072 0.074501712 0.28495635 0.77913547 0.56030658 cg21137823 PRKCZ 5590 1.7907 0.074504229 0.28495635 1.27469252 0.56842477 cg05011018 TRIM 16 10626 -1.79067 0.074509467 0.28495635 0.79058518 0.56272691 cgl8638253 ACVR1C 130399 1.79058 0.074524764 0.28495635 1.27221139 0.55027229 cgl0519140 SLC29A1 2030 1.79043 0.074548036 0.28495635 1.26974423 0.53529649 cg01965939 SH3TC2 79628 1.79041 0.074551166 0.28495635 1.27270397 0.54921339 cgl5059511 DNAJC17 55192 -1.79015 0.0745938 0.285062331 0.78122134 0.55455829 cgl8841952 GPR115 221393 -1.78994 0.07462761 0.285109167 0.78138347 0.55652481 cgl8530324 KIAA0427 9811 1.78989 0.074635874 0.285109167 1.26591694 0.5612142 cgl0149329 MGC33302 256471 1.78947 0.07470269 0.285248439 1.2804578 0.57069383 cg23325242 CYB5R3 1727 1.78937 0.074719381 0.285248439 1.27451339 0.55425575 cg22927043 NPPB 4879 1.78936 0.074721048 0.285248439 1.27743813 0.55233965 cgl3346032 TBC1D22A 25771 1.78922 0.074743489 0.285248439 1.27838837 0.55652481 cg20051177 TCF20 6942 -1.7892 0.074746916 0.285248439 0.77745398 0.55854175 cgl8519564 RCL1 10171 1.78881 0.074810268 0.285433243 1.27738602 0.568929 cg20163033 C4orf8 8603 -1.78857 0.074848008 0.285457757 0.776508 0.55475998 cg25411534 C2orfl5 150590 1.78838 0.07487829 0.285457757 1.2799444 0.55360024 cg06277277 NR1I3 9970 -1.78837 0.074879904 0.285457757 0.77746787 0.58329972 cg20543571 C15orf43 145645 -1.78826 0.074898465 0.285457757 0.77004477 0.53882614 cg05163071 RET LB 84666 -1.78796 0.074946665 0.285457757 0.78528897 0.54770069 cgl4150666 IL8RB 3579 -1.78792 0.074953117 0.285457757 0.78063176 0.55274304 cg26112639 CIAS1 114548 1.78783 0.074968718 0.285457757 1.27228547 0.55294474 cgl3908977 RSL1D1 26156 -1.78773 0.074984252 0.285457757 0.78557584 0.56514724 cg21151355 GJB3 2707 1.78768 0.074992935 0.285457757 1.27496359 0.55828963 cgl7625032 NOD27 84166 -1.78763 0.075000892 0.285457757 0.7760708 0.55556676 cg00916199 PRO 1580 55374 1.78732 0.07505127 0.285457757 1.26206298 0.57079468 cg06191203 RIF1 55183 -1.78718 0.075072743 0.285457757 0.7893091 0.55117991 cgl3351698 CBX3 11335 1.78712 0.075082507 0.285457757 1.2752516 0.57508068 cgl3240639 ZMAT5 55954 1.78705 0.075094368 0.285457757 1.28131439 0.56444131 cg08859916 PTEN 5728 1.78703 0.075097651 0.285457757 1.27323365 0.56403792 cgl7260954 ATP 1 OA 57194 -1.78686 0.075125003 0.285457757 0.78156354 0.56562626
eg 15448599 C3orf45 132228 -1.78679 0.075137102 0.285457757 0.78608621 0.55970149 cg22318304 SPA17 53340 1.78678 0.075137356 0.285457757 1.28439639 0.56383622 cgl0732834 KIAA1632 57724 -1.78675 0.07514329 0.285457757 0.78582023 0.55430617 cgl2554476 GP2 2813 -1.78673 0.075145422 0.285457757 0.77730615 0.57432432 cg09618028 COX11 1353 1.7867 0.075150592 0.285457757 1.274781 0.56792053 cg21026663 HIST1H4D 8360 1.78656 0.075173393 0.285457757 1.27423598 0.55975192 cgl7067942 C5orfl4 79770 -1.78646 0.075190238 0.285457757 0.78047245 0.55813836 cgl3801381 CCND2 894 1.78633 0.075210269 0.285457757 1.2803569 0.55319685 cg20868410 HBEGF 1839 1.78627 0.075220217 0.285457757 1.27638893 0.54074224 cg05680424 BPGM 669 1.78627 0.07522036 0.285457757 1.27232494 0.57397136 cg01036173 C9orf46 55848 1.78612 0.075244377 0.285457757 1.27086895 0.53756555 cgl4037665 PXDN 7837 1.78611 0.075246339 0.285457757 1.27065455 0.55153288 eg 19944367 RGS3 5998 -1.78609 0.075249591 0.285457757 0.78167005 0.55007059 cgl0432620 FA2H 79152 1.78581 0.07529545 0.285575071 1.27457403 0.55773497 cg21561142 DEK 7913 1.78571 0.075311906 0.285580844 1.27210845 0.55763413 cg20028291 BCAS4 55653 -1.78543 0.075357521 0.285632495 0.78458823 0.55576846 cgl5835825 HTR5A 3361 1.78528 0.075381574 0.285632495 1.28063592 0.55334812 cg00891278 CCDC37 348807 -1.78526 0.075384371 0.285632495 0.78534605 0.55556676 cgl3439299 DNAJC5G 285126 -1.78526 0.075385274 0.285632495 0.78338643 0.57538322 cgl6756620 PPIG 9360 1.78514 0.075404002 0.285646858 1.28205847 0.56504639 cg27655855 CST9L 128821 -1.78479 0.075461864 0.285685831 0.78703947 0.53484268 eg 12844497 AURKB 9212 1.78474 0.075468655 0.285685831 1.28150411 0.56126462 cgl5437432 TMED9 54732 1.78474 0.075468787 0.285685831 1.26871277 0.55627269 cg03005261 FU20647 55013 1.78463 0.075487513 0.285685831 1.28571433 0.56726503 cg22415472 SLC5A7 60482 -1.78457 0.075497491 0.285685831 0.78783554 0.56600444 cg00569620 ABHD10 55347 1.78453 0.075503926 0.285685831 1.27780613 0.56660952 eg 11662098 GO PC 57120 1.78409 0.075575273 0.285899219 1.26696153 0.56701291 cg23243617 CAMK1 8536 1.78387 0.075611534 0.285940811 1.27049313 0.58017346 cgl6806347 FUK 197258 1.78377 0.075627518 0.285940811 1.27788964 0.55289431 cg20193716 MGAT1 4245 1.78371 0.07563711 0.285940811 1.28353297 0.55148245 cg07084709 Geo ml 145781 -1.78363 0.075650722 0.285940811 0.78844596 0.54699476 cg22560190 CNTNl 1272 -1.78349 0.075672918 0.285940811 0.78486706 0.5453812 cg01693350 WT1 7490 1.78347 0.075675985 0.285940811 1.27508391 0.56524808 cgl5665653 WDTC1 23038 -1.7833 0.07570368 0.285975029 0.78553396 0.54936466 cg26359204 NKX6-1 4825 1.78322 0.075716744 0.285975029 1.27650538 0.57094595 cgl9332303 C0MMD2 51122 1.78314 0.075729904 0.285975029 1.26632217 0.54835619 cg22954818 AP0BEC3A 200315 -1.78299 0.075754761 0.286012413 0.78867768 0.56393707 cg00386408 TGFBI 7045 1.78267 0.07580694 0.286141384 1.26565691 0.57210569 cg24568646 CCT8 10694 1.78256 0.075824161 0.286141384 1.28853068 0.55894514 cg06436504 D0C1 11259 -1.7825 0.07583381 0.286141384 0.78125984 0.57800524 cg22139878 IFIT5 24138 1.78217 0.075888673 0.286155962 1.2719419 0.56544978 eg 11792664 UQCR 10975 1.78208 0.075903889 0.286155962 1.27913467 0.55128076
cg08214328 CTPS2 56474 1.78206 0.075905781 0.286155962 1.27171264 0.54790238 cgl2072001 SPON2 10417 1.78204 0.075909511 0.286155962 1.26774558 0.56257564 cg02212280 MMP1 4312 -1.78202 0.075912494 0.286155962 0.78369961 0.54243142 cgl9118533 TRAF3IP2 10758 1.78193 0.075927574 0.286156399 1.27607583 0.57800524 cg01242619 PLEC1 5339 1.78149 0.075998885 0.286331037 1.2761771 0.5577854 cg27257408 ACSBG1 23205 -1.78139 0.076016465 0.286331037 0.7838502 0.56237394 cg26701826 MGC26963 166929 1.78137 0.076018831 0.286331037 1.28943832 0.57956837 cgl0174687 FAM98B 283742 1.78113 0.076057931 0.286370228 1.27680652 0.55561718 cg26359240 HSDL1 83693 -1.78113 0.076059187 0.286370228 0.78114644 0.54840662 cg09997082 GIPR 2696 1.78101 0.076078508 0.286386589 1.26726485 0.56081081 cg06499565 NDRG3 57446 1.78092 0.076093718 0.286387469 1.27305805 0.54326341 cg06473539 NOS1AP 9722 1.78076 0.076118704 0.286425135 1.27380909 0.56323114 cg04275881 SLAMF8 56833 1.7802 0.07621168 0.286718573 1.2727998 0.55117991 cg23403256 MBD1 4152 1.77993 0.076255929 0.286797413 1.26370712 0.57936668 cg24527001 NDUFB1 4707 1.77989 0.076262631 0.286797413 1.27756222 0.56217225 cg26380756 JOSD1 9929 -1.77954 0.076320097 0.286883001 0.770828 0.5584409 cgl9108718 LOC317671 317671 1.77952 0.076322499 0.286883001 1.27549222 0.55294474 cgl3059782 CNTNAP3 79937 -1.77938 0.076345958 0.286883001 0.78869483 0.52501009 cgl9657082 ZMPSTE24 10269 1.77926 0.076364798 0.286883001 1.26941275 0.56403792 cg20449692 CLDN11 5010 1.77926 0.076365155 0.286883001 1.26098652 0.56973578 eg 16959606 ATP1B1 481 1.77905 0.07640033 0.286883001 1.29179492 0.55707947 cg03001647 MPZL1 9019 1.77903 0.076402722 0.286883001 1.27419003 0.56025615 cg26097271 MED6 10001 1.77896 0.076414733 0.286883001 1.27454176 0.56580274 cgl9055458 MYLIP 29116 1.77892 0.076420408 0.286883001 1.28757015 0.56086123 cgl7981339 SBEM 118430 -1.77868 0.076461112 0.286979464 0.78571583 0.57099637 cgl6525761 RPL34 6164 1.77841 0.076505534 0.287089848 1.2788018 0.55879387 cg06417225 PEBP1 5037 1.77828 0.076526649 0.287091533 1.26762926 0.5725595 cgl l554937 HSD17B3 3293 -1.77815 0.076548412 0.287091533 0.77780491 0.56756757 cg25960567 ITPR2 3709 1.77813 0.076551022 0.287091533 1.27077623 0.56693727 cgl9816938 ABR 29 1.77772 0.076618457 0.287288093 1.27592595 0.56232352 cgl2377712 ATP6V1G1 9550 1.77745 0.076662987 0.287376573 1.28228237 0.5648447 cg21835622 DPYSL3 1809 1.7774 0.07667211 0.287376573 1.26530897 0.55733159 cg01254505 BST2 684 1.77708 0.076724866 0.287517955 1.28093195 0.54533078 cg21893220 SMC2L1 10592 1.77695 0.076745815 0.287527613 1.27170797 0.56565147 cg02207610 PPP1R12C 54776 1.77688 0.076757515 0.287527613 1.27805729 0.5524405 cg22182945 NYD-SP26 85438 -1.77667 0.076791575 0.287595361 0.77913421 0.56832392 cgl l402505 FBX027 126433 1.77659 0.076805679 0.287595361 1.29249331 0.54754942 cg04757428 STMN3 50861 -1.77648 0.076823199 0.287604648 0.7876456 0.57018959 cg23761264 PLCG1 5335 1.77637 0.076841555 0.28761706 1.26240721 0.57008875 cgl3847113 MGC24975 163154 -1.77582 0.076931604 0.287846527 0.77469729 0.55269262 cg09793197 ROPN1 54763 -1.77575 0.076944494 0.287846527 0.77396526 0.55294474 cg26751631 RNF12 51132 1.77569 0.076953903 0.287846527 1.27294872 0.57639169
cgl4301635 C2 717 -1.77563 0.07696307 0.287846527 0.78556447 0.54749899 cg09600829 C9orflOOS 158293 1.77538 0.077004602 0.287922807 1.28144232 0.56146632 cgl6668394 MEN1 4221 1.77533 0.077013578 0.287922807 1.26675446 0.54220452 cg07327328 CEP250 11190 1.77517 0.077038996 0.287961535 1.27292259 0.5639875 cg01856970 IL15 3600 1.77439 0.077168632 0.288284977 1.26699884 0.55430617 eg 14576628 PRMT1 3276 1.77427 0.077189075 0.288284977 1.28076759 0.55284389 cg03963198 IRX4 50805 -1.77421 0.07719904 0.288284977 0.7886826 0.55360024 cg03837750 LRRC44 127255 1.7742 0.07719954 0.288284977 1.2811833 0.56983663 cg21870668 SNRPN 6638 1.77418 0.077202833 0.288284977 1.26450876 0.54618798 cgl6382256 EPHB3 2049 1.77387 0.077255074 0.288284977 1.27506975 0.55753328 cgl0356060 DNAJC18 202052 1.77387 0.07725586 0.288284977 1.27000825 0.56040742 cg08399444 GSG1 83445 1.77386 0.077256543 0.288284977 1.29038692 0.54825535 cg23555120 NUAK1 9891 1.77372 0.077280497 0.288284977 1.2606493 0.55571803 cg08836024 RARSL 57038 -1.77367 0.077288357 0.288284977 0.77893646 0.55970149 cg25195673 GFPT1 2673 -1.77361 0.077298409 0.288284977 0.78536462 0.56005446 cg24791546 DDX23 9416 1.77355 0.077307603 0.288284977 1.27782354 0.54931424 cg09682183 UNC93A 54346 1.77347 0.077321507 0.288284977 1.28068145 0.54951593 cg21849289 Clotfl23 54987 1.77336 0.077339273 0.288295009 1.27859449 0.55687777 cg07053469 EID-3 126272 1.77287 0.077420287 0.288540754 1.26583354 0.55718032 cgl3702536 GPR81 27198 -1.77276 0.077439345 0.288555546 0.78411212 0.58143405 cgl5359413 FIGNL1 63979 1.77249 0.077484216 0.288666495 1.27344544 0.55617184 cg08301503 FU43752 401253 1.7722 0.077532918 0.288791673 1.27404418 0.57397136 cg07496902 ASB14 142686 -1.77134 0.077674833 0.289163642 0.78464395 0.5479528 cg25545088 ABCC10 89845 -1.77133 0.077677361 0.289163642 0.78790539 0.56832392 cg07038887 BLMH 642 1.77132 0.077678146 0.289163642 1.27382614 0.5657019 cg07964133 HNRPD 3184 1.77103 0.077727105 0.289289584 1.28131772 0.55682735 cg26404725 CYP26C1 340665 -1.77072 0.077778663 0.28942341 0.7780029 0.54613756 cg03247626 HINT3 135114 1.77063 0.077793332 0.28942341 1.26749279 0.54008673 cg07699440 FAH 2184 -1.77037 0.077836786 0.289528749 0.78688746 0.54593586 cg24046474 LRSAM1 90678 1.77018 0.077868627 0.289590857 1.27615369 0.54664179 cg05142576 HIST1H2AH 85235 1.76961 0.077964079 0.289850753 1.27954332 0.56726503 cgl6332060 FU21827 56912 1.76957 0.07797151 0.289850753 1.27437736 0.54679306 cg09131135 SUPT7L 9913 1.76944 0.077992709 0.289850753 1.27136708 0.5534994 cg06493994 SCGN 10590 1.76936 0.078005284 0.289850753 1.26444117 0.5841065 cg20925954 DUSP5 1847 1.76931 0.078014297 0.289850753 1.27080626 0.55808794 cgl ll57872 FU11021 65117 1.7691 0.078048732 0.289903897 1.27852343 0.57906414 cg06852652 CYP2C18 1562 -1.76904 0.078058921 0.289903897 0.782593 0.54255748 cg01289103 KA21 125113 1.76845 0.078157613 0.290214067 1.27184153 0.57462687 cg09980522 GRIA4 2893 1.76803 0.078228171 0.290336937 1.27427939 0.55042356 cg24352688 OFD1 8481 -1.76799 0.078235346 0.290336937 0.78219418 0.55032271 cg03072378 DLX4 1748 1.76798 0.078236251 0.290336937 1.27232507 0.55203711 cg02505689 DBF4B 80174 1.76772 0.078280448 0.290413895 1.26449152 0.56272691
cg05463705 ZNF143 7702 1.76768 0.078287362 0.290413895 1.27353133 0.55707947 cg05996238 PAGE 2 203569 -1.76738 0.078337406 0.290543175 0.78823108 0.55395321 cgl4078309 MT 27349 -1.76716 0.078373929 0.290586802 0.7930615 0.57558491 cg25163134 PSMC4 5704 1.76713 0.07837956 0.290586802 1.26932782 0.56151674 cg06084117 PLXNA4B 91584 -1.76676 0.078442094 0.29076227 0.77598027 0.56000403 cg01679262 RANBP5 3843 1.76664 0.07846196 0.290779546 1.2580076 0.56015531 cg05064181 ABLIM 1 3983 -1.76632 0.078515846 0.290906153 0.77734901 0.57013917 cg08035942 ZADH2 284273 1.76602 0.078565325 0.290906153 1.27201969 0.55904599 cgl3053396 CIS 716 -1.7659 0.07858551 0.290906153 0.78566879 0.54825535 cg20320468 LAIR1 3903 1.7659 0.07858568 0.290906153 1.27821825 0.55869302 cg08906015 MGC15476 147906 -1.76587 0.078591061 0.290906153 0.7866907 0.56580274 cg22857957 FM05 2330 1.76579 0.078604512 0.290906153 1.27431428 0.556071 cg23158022 FU21742 84167 -1.76578 0.078606545 0.290906153 0.78182192 0.55662566 cg25677688 TAS2R48 259294 -1.7656 0.078637185 0.290906153 0.78687146 0.55904599 cg07971188 HCP5 10866 1.76534 0.078680591 0.290906153 1.26943318 0.57780355 cgl7788013 SPINK5 11005 -1.76524 0.078696802 0.290906153 0.78406357 0.5498689 cgl9191401 SRGAP1 57522 1.76516 0.078711485 0.290906153 1.2738798 0.57245865 cgl7718302 HIST1 H3J 8356 1.76502 0.078734311 0.290906153 1.27664168 0.56212182 cgl3446199 PSCA 8000 -1.76491 0.078753161 0.290906153 0.79113394 0.57639169 cgl3555884 CTGLF1 119016 -1.76489 0.078755936 0.290906153 0.78272787 0.56988705 cg05492845 VEGFB 7423 1.76487 0.078759482 0.290906153 1.26631237 0.54689391 cgl8712919 BRE 9577 -1.76466 0.078794342 0.290906153 0.78170953 0.53751513 cgl5383574 ATP5S 27109 1.76456 0.078811122 0.290906153 1.2706246 0.53201896 cg09298289 CENPH 64946 1.76455 0.078813105 0.290906153 1.27154502 0.56509681 cgl l321895 PLAG1 5324 1.76449 0.078824338 0.290906153 1.26545154 0.55460871 cgl8755204 FAM45A 404636 -1.76447 0.078826778 0.290906153 0.78546776 0.55228923 cg22658985 WDR40A 25853 1.76444 0.078832902 0.290906153 1.27005714 0.56192013 cg06516124 WT1 7490 1.76439 0.078839951 0.290906153 1.27743234 0.55203711 cgl0741760 HTR6 3362 1.76436 0.078846009 0.290906153 1.26803965 0.564643 cgl3744304 UNC50 25972 1.76402 0.07890373 0.29106296 1.27212502 0.54069181 cg00075967 STRA6 64220 -1.76369 0.078958297 0.291208074 0.78738767 0.56908027 cg08733774 RANBP2 5903 1.76304 0.079067626 0.291396411 1.27909741 0.57175272 cgl4547335 ATP2B2 491 1.76301 0.079074042 0.291396411 1.26887488 0.54291045 cg09163442 SEC61G 23480 1.7629 0.07909171 0.291396411 1.27501876 0.57230738 cg25346972 C14orfll2 51241 1.76274 0.079118699 0.291396411 1.29556299 0.58324929 cg07444907 UBLCP1 134510 1.76271 0.07912484 0.291396411 1.26895631 0.55445744 cg26259865 LOC124220 124220 -1.76263 0.079138226 0.291396411 0.79273881 0.55743243 cg08797106 HIST1H3A 8350 1.76249 0.079162253 0.291396411 1.26559736 0.56413877 cg22283148 LSM6 11157 1.76247 0.07916449 0.291396411 1.27149833 0.55965107 cg01469547 OR5P3 120066 -1.76245 0.079168202 0.291396411 0.7801348 0.57311416 cgl5111734 C10orfl3 143282 1.76242 0.079172743 0.291396411 1.28654491 0.55743243 cg04581377 SLC35F2 54733 1.7624 0.079176981 0.291396411 1.29242833 0.56429004
cg09937039 BATF 10538 1.76223 0.079205812 0.291446427 1.26768622 0.55410448 eg 18854045 FU33534 285150 -1.76193 0.079256985 0.291553843 0.7769932 0.5532977 cg23089840 LRRC3 81543 1.76187 0.079265824 0.291553843 1.26771723 0.5515833 eg 11256445 HCLS1 3059 -1.76172 0.079292643 0.291553843 0.77671957 0.54891085 cg05922591 LILRB4 11006 -1.7617 0.079295989 0.291553843 0.79115412 0.5569282 cg20449833 RHOQ 23433 1.7616 0.079312133 0.291557143 1.2657231 0.54613756 cg09995854 IL1F8 27177 -1.7615 0.079329949 0.291566586 0.78491936 0.5541549 cgl0423830 PGEA1 25776 1.76122 0.079376206 0.291680539 1.26295029 0.56323114 cg08680731 VPS41 27072 1.76099 0.079415873 0.291762387 1.27357085 0.55690299 cg23261102 DNAJC18 202052 1.76091 0.079428995 0.291762387 1.27663118 0.55087737 cg22131691 PDE1C 5137 1.76062 0.079478457 0.291888009 1.27181868 0.55465914 cg08379517 LRRC25 126364 -1.76048 0.079501685 0.291915547 0.78274698 0.55067568 cg00939965 PRRG1 5638 -1.76036 0.079523083 0.291915547 0.79085485 0.57235781 cg26989103 TRHR 7201 -1.76022 0.079545709 0.291915547 0.78904277 0.56701291 cgl6001460 PRIM2A 5558 1.76022 0.079547017 0.291915547 1.27665008 0.56227309 cg23232084 UBL4A 8266 -1.75991 0.079599573 0.29195214 0.77773282 0.55223881 cg01307730 HIST1H2AA 221613 -1.75989 0.079601616 0.29195214 0.7848046 0.56494554 cgl3653456 VARS 7407 1.75989 0.07960279 0.29195214 1.26503156 0.56197055 cg21501064 Sep-06 23157 1.75964 0.079644544 0.291984759 1.263664 0.57634127 cg25229015 WDR61 80349 1.75959 0.079652656 0.291984759 1.26496128 0.5558693 cg02075593 GSTA3 2940 -1.75957 0.07965749 0.291984759 0.78753848 0.56227309 cg00136736 C22orfl9 8563 1.7593 0.079703548 0.292090449 1.26933652 0.55153288 cg07478122 HBII-13 347686 -1.75922 0.079716872 0.292090449 0.78564438 0.55894514 cgl2938998 GAB3 139716 1.75897 0.07975918 0.292189483 1.26087878 0.55818879 cg26394380 SFTPB 6439 -1.75865 0.079814103 0.292218218 0.78940394 0.55304558 cgl2315959 DNAJC12 56521 -1.75857 0.079827814 0.292218218 0.78292761 0.56479427 cg02345317 NLGN3 54413 -1.7585 0.079838476 0.292218218 0.78524164 0.56343284 cg06712026 CSTF2T 23283 1.75849 0.079840037 0.292218218 1.27306325 0.5751311 cg02620769 CCDC65 85478 1.75847 0.079843429 0.292218218 1.28210696 0.56529851 cg22148243 CXorf38 159013 1.75832 0.079868878 0.292232456 1.28458133 0.55526422 cgl7100200 GUCA2B 2981 -1.75827 0.079877883 0.292232456 0.78867121 0.55728116 cgl4893163 PCDH17 27253 1.75743 0.080021989 0.292691934 1.27172594 0.55854175 cg23213170 FCMD 2218 1.75727 0.080048918 0.292691934 1.26366066 0.55037313 cg06196379 TREM1 54210 1.75727 0.080049393 0.292691934 1.27652503 0.56081081 cg20275344 RAB9B 51209 -1.75713 0.080072132 0.292719108 0.78943656 0.55395321 cg25234611 VWA1 64856 1.75696 0.080101955 0.292726187 1.26573124 0.56787011 cgl3760253 DNAJC5B 85479 -1.75694 0.08010531 0.292726187 0.78676968 0.5550121 cg02854090 HIST1H2AA 221613 -1.75685 0.080119991 0.292726187 0.78733879 0.55097822 cgl5610233 ADAM7 8756 -1.75658 0.08016727 0.292842976 0.77856143 0.54326341 cg07466531 SRP14 6727 1.7564 0.080197348 0.292875858 1.27508077 0.55944938 cg09666654 MYOIB 4430 1.75634 0.080206903 0.292875858 1.26728379 0.56958451 cg26802333 MT1X 4501 -1.7559 0.080283673 0.29297534 0.79040092 0.5430113
cg03532957 CHSY1 22856 1.75584 0.080292771 0.29297534 1.26234721 0.52415288 cg23202409 Cllorf48 79081 1.75584 0.080293691 0.29297534 1.28049623 0.55183542 cg05492113 TUB 7275 -1.75583 0.080295429 0.29297534 0.78351528 0.56534893 cg21537939 Sep-10 151011 -1.75568 0.080320407 0.29301057 0.79290795 0.52677491 cgl4116122 CART1 8092 1.75467 0.080493102 0.293458996 1.2712392 0.57422348 cg20988616 ENPP3 5169 -1.75463 0.080500839 0.293458996 0.78701458 0.55516337 cg01528948 ADH1B 125 1.75463 0.080501097 0.293458996 1.27071091 0.57518153 cg05055150 MAG 4099 1.7546 0.080505951 0.293458996 1.26225169 0.54860831 eg 18844850 COPS7A 50813 1.75437 0.08054541 0.293458996 1.27884793 0.56363453 cgl7509612 C9orf78 51759 1.75434 0.080550664 0.293458996 1.26926168 0.55874345 cg02633817 FXYD3 5349 -1.75405 0.080600663 0.293458996 0.77579572 0.55990319 cgl5076218 PIK3R3 8503 1.75399 0.080611252 0.293458996 1.27444756 0.5770472 cg06850526 MGC15523 124565 1.75394 0.080619327 0.293458996 1.26499901 0.55909641 cg01495509 KCNMB1 3779 1.75383 0.080638718 0.293458996 1.2769423 0.55970149 cg20425130 KLHL6 89857 1.75382 0.080639339 0.293458996 1.26522129 0.55173457 cgl7692403 R3HDML 140902 1.75375 0.080651219 0.293458996 1.27308781 0.56136547 cg20956373 USP48 84196 1.75371 0.080657997 0.293458996 1.25904525 0.55133118 cgl l908570 KIAA0040 9674 1.75371 0.080658173 0.293458996 1.26781453 0.56302945 eg 12884406 COL11A1 1301 1.75305 0.080771779 0.293816426 1.26896809 0.56539936 cgl6837769 NDUFA4 4697 1.7529 0.080797149 0.293852816 1.27320806 0.58355184 cg06812033 NKD1 85407 -1.75259 0.08085167 0.293900023 0.78663298 0.57997176 cgl5188688 CDC45L 8318 -1.75253 0.080861981 0.293900023 0.77563526 0.5532977 cgl l320084 R F2 6045 -1.75245 0.080874585 0.293900023 0.78607703 0.5639875 cg07651857 RNF4 6047 1.7523 0.080901848 0.293900023 1.26165957 0.56439088 cgl l360149 OR2V2 285659 -1.75228 0.08090373 0.293900023 0.78555416 0.58345099 cg26212229 SNRPD1 6632 -1.75206 0.080943136 0.293900023 0.77807402 0.56575232 cg22972055 UNC84A 23353 -1.75205 0.080944977 0.293900023 0.78374717 0.56015531 cgl0493166 PTGS1 5742 1.75193 0.080964208 0.293900023 1.26714107 0.56454215 cgl5933546 DNAH8 1769 -1.75187 0.080974534 0.293900023 0.78232348 0.57462687 eg 14449051 SLC6A15 55117 1.75187 0.080975759 0.293900023 1.25800452 0.5881908 cg21599792 FZD4 8322 1.75185 0.080979188 0.293900023 1.27166762 0.55965107 cg09888137 ACTR1A 10121 1.75165 0.081013398 0.293968393 1.26799203 0.54049012 cg l3391638 FU13576 64418 1.75146 0.081046283 0.294015808 1.268062 0.56474385 cg25151806 ELOVL2 54898 -1.75132 0.081070553 0.294015808 0.78451458 0.54588544 eg 14962548 TXNDC9 10190 1.7513 0.081072591 0.294015808 1.27300901 0.59000605 cg22340747 GATM 2628 -1.75101 0.08112401 0.294125691 0.7839538 0.54966721 eg 14070647 RSP02 340419 1.75095 0.081133652 0.294125691 1.26495475 0.56045785 cg04999691 C7orf29 113763 1.75085 0.081151261 0.29413377 1.27263201 0.55894514 cgl3277160 LOC151194 151194 -1.75057 0.081199302 0.294141579 0.78838273 0.55395321 cg01692815 AP3B1 8546 1.75037 0.081233259 0.294141579 1.27606293 0.5717023 cg08440425 LRRC51 220074 1.75037 0.081233966 0.294141579 1.26768278 0.5419524 cg09918512 CWF19L2 143884 -1.75036 0.081235607 0.294141579 0.78335745 0.56323114
cg24237439 FU25422 202151 1.75027 0.081251149 0.294141579 1.27150314 0.55917205 eg 11666924 STXBP3 6814 1.75009 0.081281816 0.294141579 1.26656862 0.54487697 cg09462587 MGC11102 84285 1.74983 0.081327619 0.294141579 1.26459242 0.55556676 cg09439093 PECI 10455 1.74976 0.081340312 0.294141579 1.27025104 0.56560105 cg24471894 KIAA0020 9933 1.7497 0.081349572 0.294141579 1.27814005 0.55511295 cg24765005 BEX2 84707 -1.74966 0.081356549 0.294141579 0.78466054 0.55970149 cgl7511416 C9orf93 203238 1.74963 0.081361394 0.294141579 1.27005567 0.56413877 cgl5679651 MAP4K1 11184 1.74952 0.081381686 0.294141579 1.26396316 0.56751714 cg00065385 ACTL7A 10881 -1.74946 0.081391211 0.294141579 0.78617842 0.54628883 cgl ll91337 PLTP 5360 -1.7494 0.081401853 0.294141579 0.78759907 0.53907826 cg27398499 TACSTD2 4070 1.74938 0.081404768 0.294141579 1.27189606 0.56502118 cgl5223781 FER 2241 1.74931 0.081416803 0.294141579 1.28052774 0.55208754 cgl3744194 OCLN 4950 1.74931 0.081417191 0.294141579 1.26154607 0.58420734 cg05385377 TMEM51 55092 1.74915 0.08144507 0.294141579 1.26726401 0.55702904 cg07558006 TAAR8 83551 -1.74915 0.081445667 0.294141579 0.78309929 0.56534893 cgl2911791 CSHL1 1444 -1.74897 0.081476446 0.294197177 0.79350109 0.5575837 cg08871917 GATAD1 57798 1.74881 0.081504553 0.294243107 1.26361779 0.56297902 cg20199629 SAMD14 201191 1.74871 0.081521146 0.294247461 1.27238061 0.54376765 cg01999333 CASP14 23581 -1.74855 0.081549706 0.294295001 0.78701349 0.55095301 cg06282240 CENPJ 55835 -1.74821 0.081608663 0.294408275 0.78729453 0.54996975 cg08009328 HIST1H2BF 8343 1.7481 0.081626902 0.294408275 1.2587124 0.55927289 cg22722822 CHIC2 26511 1.7481 0.081627282 0.294408275 1.27375153 0.55642396 cgl8466173 C21orf93 246704 -1.74789 0.081663247 0.294482449 0.78304039 0.56267648 cg20077393 CGN 57530 1.7475 0.08173049 0.294568159 1.26503814 0.56272691 cg09531892 LRP12 29967 1.74749 0.081733453 0.294568159 1.26051087 0.56983663 cg05824484 IL17R 23765 1.74748 0.08173538 0.294568159 1.26077804 0.55375151 cgl4831838 CDK5R2 8941 1.74737 0.081753229 0.294568159 1.26821255 0.55743243 cg09952620 HSPC023 28974 1.74722 0.08177915 0.294568159 1.26496834 0.56746672 cg03155724 C10orfl04 119504 1.74722 0.081779439 0.294568159 1.27162497 0.56227309 cgl2576700 CDK5RAP2 55755 1.74645 0.081913248 0.294994575 1.26565128 0.56514724 cg06907544 FU35785 283796 -1.74588 0.082013111 0.295268361 0.7848179 0.55259177 cg23435440 HCAP-G 64151 1.74584 0.082020154 0.295268361 1.28404815 0.55430617 cg04456238 WT1 7490 1.74552 0.082076222 0.295414593 1.26871543 0.54805365 eg 16989646 SLC25A15 10166 1.74496 0.082173322 0.295535404 1.26203669 0.57467729 cg01675895 AFM 173 -1.74493 0.082178127 0.295535404 0.78648733 0.56817265 cg22066521 ABCB5 340273 -1.74488 0.082187142 0.295535404 0.7903808 0.56070996 cg20322862 TGIF 7050 1.74477 0.082205995 0.295535404 1.26064278 0.56918112 cg01851399 PKP2 5318 1.74477 0.082206596 0.295535404 1.27192003 0.55339855 cg05944800 INSIG2 51141 1.74465 0.082227789 0.295535404 1.27085976 0.55304558 cg03270167 RAM PI 10267 1.74464 0.082228994 0.295535404 1.2689378 0.57649254 cg01385430 VPS45A 11311 1.74462 0.082233424 0.295535404 1.25852009 0.56272691 cg06550629 GPR133 283383 -1.74452 0.082249495 0.295537621 0.78671811 0.56106293
cgl0691387 IQCF2 389123 -1.74439 0.08227294 0.295566326 0.78539902 0.55617184 cg08711674 A T1S1 84335 1.74421 0.082304264 0. 295605807 1.27024184 0.54699476 cg26054540 NKD2 85409 1.74406 0.082330279 0. 295605807 1.26825764 0.53933038 cg00745543 H1T2 341567 -1.74406 0.082330304 0. 295605807 0.77944312 0.56665994 cgl4098132 CGRRF1 10668 1.74391 0.082357417 0. 295645703 1.25434227 0.5665591 cg26292864 ITM2C 81618 1.74382 0.082372337 0. 295645703 1.25953704 0.56731545 cg20697204 FU40172 285051 -1.74363 0.082405268 0. 295690189 0.78852702 0.53222065 cg09563216 Clorf51 148523 1.74357 0.082415656 0. 295690189 1.26706963 0.56434046 cg01982597 PGBD3 267004 -1.74348 0.082432088 0. 295693665 0.77723956 0.56630698 cg07510080 HIF1AN 55662 1.74314 0.082491897 0. 295710546 1.26785075 0.56595401 cg07970007 GBP1 2633 -1.74313 0.082492583 0. 295710546 0.78480613 0.56766842 cg03958979 NR2E1 7101 - 1.7431 0.082498004 0. 295710546 0.78817268 0.53262404 cg27465849 THEDC1 55301 -1 .74292 0.082530025 0. 295710546 0.78387541 0.55183542 cg08034397 TMEM16K 55129 1 .74291 0.08253093 0. 295710546 1.26983885 0.56368495 cg08721347 ALG14 199857 1 .74269 0.082570782 0. 295710546 1.26882905 0.5541549 cgl6324018 RBED1 84173 -1 .74268 0.082571625 0. 295710546 0.78643865 0.56161759 cg25482967 MRPS10 55173 1 .74267 0.082573542 0. 295710546 1.28613556 0.56192013 cg24402880 PLAC8 51316 1 .74266 0.082575967 0. 295710546 1.26832623 0.55178499 cg22932215 C0PS7B 64708 1 .74242 0.082616751 0. 295801202 1.27724672 0.55198669 cg08768421 GDA 9615 -1 .74232 0.08263412 0. 295808006 0.7819477 0.54780153 cg07965714 XPA 7507 1 .74204 0.082684601 0. 295847844 1.26499193 0.56676079 cg05499853 C10orf97 80013 1 .74198 0.08269435 0. 295847844 1.2638105 0.56867689 cg20856834 OR12D3 81797 -1 .74191 0.082706527 0. 295847844 0.78558264 0.54714603 cgl6011258 NECAP2 55707 1 .74191 0.082707132 0. 295847844 1.2698129 0.56776926 cg21168622 ZNF350 59348 1 .74177 0.0827311 0. 295878234 1.27440751 0.54180113 cgl9861697 DMTF1 9988 1.7415 0.08277881 0. 295966635 1.26134798 0.55203711 cg08331840 FKSG2 59347 -1.74145 0.082786772 0. 295966635 0.78906118 0.57139976 cg09446127 UBADC1 10422 1.7413 0.082813304 0. 296006148 1.2649068 0.56176886 cg06043190 EML4 27436 -1 .74098 0.082870577 0. 296155509 0.78914471 0.54164986 cg05501357 HIPK3 10114 1 .74087 0.082889161 0. 296166574 1.26664174 0.56590359 eg 10247268 PFKP 5214 -1 .74068 0.082922796 0. 296231404 0.78896077 0.56650867 cgl4801726 SRP68 6730 1 .74034 0.08298331 0. 296392213 1.26261471 0.56267648 cgl5235832 ACTR2 10097 1 .74021 0.083004884 0. 296413906 1.27067986 0.55975192 cg20092728 SLC5A12 159963 -1.74 0.083043055 0.2964676 0.7905865 0.54775111 cgl l630242 AKAP10 11216 1 .73995 0.083050926 0.2964676 1.27186361 0.54734772 eg 11154798 RAI14 26064 1 .73964 0.083104981 0. 296518565 1.26993842 0.56497075 cgl6969623 ZNF331 55422 1 .73957 0.083117737 0. 296518565 1.2786307 0.56852562 cg08573893 C8orf32 55093 1 .73951 0.083129386 0. 296518565 1.28665235 0.54906212 cgl2681402 RPH3A 22895 1 .73941 0.083145384 0. 296518565 1.27782619 0.56242437 cg02144298 CEBPA 1050 1 .73936 0.083155048 0. 296518565 1.27282442 0.56897943 cg27562023 RPH3AL 9501 -1 .73934 0.083158239 0. 296518565 0.79156473 0.55813836 cg01849789 ZC3H7B 23264 1 .73922 0.083179564 0. 296539309 1.26368385 0.55117991
cg05418487 KCNQ1 3784 1.7391 0.083200866 0.296559965 1.2670144 0.55526422 cgl4517922 S P1P1 6922 -1 .73883 0.083247902 0.296672324 0, .78926863 0.57039129 cgl6267059 MFAP1 4236 1 .73871 0.08326958 0.296694284 1 .27319459 0.57205526 cg02755455 JAK1 3716 -1 .73844 0.083317827 0.296810888 0 .79062758 0.5428096 cgl7452384 MAPK10 5602 -1 .73826 0.083348943 0.296866433 0, .79165756 0.55854175 cg04166304 C14orfl06 55320 1 .73815 0.083367429 0.296876981 1 .26531734 0.56534893 cgl l099291 MGC14376 84981 1 .73762 0.083462396 0.297126218 1 .27725481 0.55249092 eg 14325649 RBMS1 5937 1 .73757 0.083470241 0.297126218 1 .28169701 0.56802138 cg21422622 RUTBC3 27352 1 .73749 0.083484032 0.297126218 1 .26529047 0.56333199 eg 14294758 LSAMP 4045 1 .73655 0.083651149 0.29763804 1 .26812169 0.57387051 cgl6692761 TAF1B 9014 1 .73651 0.083658968 0.29763804 1.269911 0.56736587 cgl2434258 FU90396 163049 1 .73621 0.083711537 0.297769668 1 .26643622 0.56524808 eg 16005443 LILRB3 11025 -1 .73593 0.083761768 0.297875202 0 .79373534 0.55924768 cg06253734 ADAM10 102 -1 .73587 0.083772359 0.297875202 0, .78665322 0.53817063 cg02735071 EIF3S3 8667 1 .73558 0.083822781 0.297999081 1 .27213842 0.56897943 cg03759077 ARL6IP6 151188 1 .73532 0.083869328 0.29803292 1 .25740811 0.54850746 cg07264679 CD163 9332 -1 .73529 0.083874324 0.29803292 0, .78520312 0.55718032 eg 11504646 RTP1 132112 -1 .73526 0.0838801 0.29803292 0, .78581294 0.55576846 cg26813908 CCDC55 84081 1 .73517 0.083896232 0.29803292 1 .26638031 0.56146632 cg01322079 SFT2D1 113402 1 .73509 0.083910225 0.29803292 1 .27197163 0.57180315 cg05837075 ER01L 30001 1 .73492 0.083939536 0.298051671 1 .27076383 0.54517951 cgl3133148 SNAPC5 10302 -1 .73488 0.083947912 0.298051671 0, .79484963 0.56116378 cg26709720 B3GALT5 10317 -1 .73479 0.083962263 0.298051671 0, .78734974 0.55551634 cg24529858 Fll 2160 1 .73469 0.083980792 0.29805496 1 .25608852 0.55138161 cg07686479 LMX1A 4009 1 .73446 0.08402122 0.29805496 1 .25585933 0.55511295 cg27072387 LTBP1 4052 1 .73446 0.08402168 0.29805496 1 .27618814 0.58082896 cg22858288 SLC22A18 5002 1 .73425 0.084058481 0.29805496 1 .26210777 0.54785196 cg21918500 ZNF124 7678 -1 .73412 0.084082751 0.29805496 0, .78751658 0.52707745 cg22477592 ATM 472 1 .73411 0.084084373 0.29805496 1 .26446533 0.57311416 cgl4242091 T0P3B 8940 1 .73409 0.084087267 0.29805496 1 .26928805 0.56711376 cg03021892 SLC38A5 92745 -1 .73408 0.084088972 0.29805496 0, .78713623 0.54286002 cg24641737 DENND2D 79961 1.734 0.084103466 0.29805496 1 .27150239 0.57316458 cg01429181 WDR42A 50717 1 .73378 0.08414298 0.298078579 1 .27197361 0.56625656 cg02033116 GPATC1 55094 1 .73369 0.084158142 0.298078579 1 .26249607 0.5753328 cg01269795 BTN3A3 10384 1 .73369 0.08415846 0.298078579 1 .25579958 0.57654296 cg24335895 C0X7A1 1346 1 .73361 0.08417248 0.298078579 1 .26986445 0.54694433 cgl5746719 DAPK1 1612 1 .73349 0.084193377 0.298097375 1 .26721991 0.58672852 cg02879662 HIF3A 64344 -1 .73315 0.084254506 0.298168817 0, .79165285 0.55405405 cgl4203179 GNAS 2778 1 .73315 0.084255043 0.298168817 1 .28552881 0.55198669 cg25034557 PACS1 55690 1 .73312 0.084260331 0.298168817 1 .26370496 0.5665591 cgl5972617 GM2A 2760 1 .73286 0.084306708 0.298171789 1 .26532134 0.55823921 cg00143998 HIST3H2BB 128312 1 .73283 0.084312217 0.298171789 1 .26375781 0.54946551
cgl2391921 ITGB1BP2 26548 -1.73277 0.084321472 0.298171789 0.79102093 0.5507261 cg21493583 CRIPT 9419 1.73265 0.084343894 0.298171789 1.27958932 0.5391791 cgl5142488 LYPD4 147719 -1.73245 0.084380141 0.298171789 0.78783193 0.55284389 cg27324619 PIB5PA 27124 -1.7324 0.084387445 0.298171789 0.79375492 0.55445744 cgl6511708 SS18 6760 1.73237 0.084394085 0.298171789 1.26718429 0.58062727 cg00321478 CRB1 23418 -1.73233 0.084400221 0.298171789 0.78413587 0.56307987 cg04230869 RRM2B 50484 1.73228 0.084409368 0.298171789 1.27605744 0.56701291 cg26130726 CYB5R4 51167 1.73224 0.084417095 0.298171789 1.26225509 0.55753328 cgl4667033 TMEM2 23670 1.73186 0.084484974 0.298350645 1.27301462 0.55934853 cg23326785 TMEM25 84866 1.73178 0.084498935 0.298350645 1.27127639 0.54356595 cg05596756 FAM 113B 91523 1.73161 0.084529583 0.29840376 1.27796143 0.55849133 cg24388263 FU10374 55702 -1.73129 0.084586452 0.298549404 0.79311555 0.54346511 cgl l070419 C4BPA 722 -1.7309 0.08465672 0.298648777 0.79205084 0.55491126 cgl l308639 BMP10 27302 -1.73081 0.084671672 0.298648777 0.78915014 0.54482654 cg08260891 PPGB 5476 1.73073 0.084686373 0.298648777 1.2628165 0.57220654 cg21165219 FAM38B 63895 -1.73069 0.08469436 0.298648777 0.78428214 0.55965107 cgl4176836 ITGAL 3683 1.73054 0.084719833 0.298648777 1.27664717 0.5438685 cgl5170424 TMEM55A 55529 1.73054 0.084720376 0.298648777 1.27086073 0.57719847 cg00032666 CXorf6 10046 -1.73052 0.084723928 0.298648777 0.79060071 0.56212182 cg07473175 AMIG02 347902 1.7304 0.084745636 0.298670243 1.26467361 0.54896128 cg06723357 CUEDC1 404093 -1.7301 0.084799635 0.298729055 0.78730593 0.560357 cg20591405 RAB6B 51560 1.73008 0.084802787 0.298729055 1.25534507 0.55828963 cg25842633 SCUBE1 80274 1.73004 0.084809188 0.298729055 1.2672586 0.5768455 cgl l074362 DENND4C 55667 -1.72993 0.084829788 0.298746588 0.78994924 0.58783784 cg09822907 EME1 146956 1.72944 0.08491703 0.298957341 1.26179991 0.55899556 cg05592398 LIMK1 3984 1.72942 0.084920899 0.298957341 1.26577773 0.55697862 cg02178898 MTRF1 9617 1.72931 0.084941181 0.298973704 1.27341827 0.55793667 cg03271651 POGZ 23126 1.72894 0.085006008 0.299060078 1.26434824 0.54311214 cg07456201 UMOD 7369 -1.72893 0.085007964 0.299060078 0.78914662 0.54654094 cg27219973 GNRHR 2798 -1.72882 0.085028858 0.299060078 0.79156214 0.54331384 cg09217923 TAAR2 9287 -1.72861 0.085065781 0.299060078 0.78886185 0.55602057 cgl0920957 JPH3 57338 1.7286 0.085067004 0.299060078 1.26049186 0.5768455 cg06384053 FU20010 54494 1.72857 0.085073891 0.299060078 1.26419458 0.56580274 cg24758027 PKIB 5570 1.72838 0.085108168 0.299060078 1.27598141 0.57253429 cg03065202 MGC17330 113791 1.72826 0.085127985 0.299060078 1.26201201 0.5472973 cgl0970251 SLC25A22 79751 -1.72823 0.085133702 0.299060078 0.79994475 0.55148245 cg02119229 BCD02 83875 1.72818 0.085142626 0.299060078 1.26881386 0.57593788 cg25745343 PLEKHB2 55041 1.72818 0.085143949 0.299060078 1.26698773 0.56212182 cg08826839 FAP 2191 -1.72812 0.085153386 0.299060078 0.78962555 0.55178499 cg21638219 PHYH2 26061 1.72781 0.085209726 0.299198135 1.2662504 0.55591973 cgl5669092 TUBB3 10381 1.72773 0.085223988 0.299198135 1.25722821 0.56418919 cg04322978 ETFB 2109 1.72755 0.085256785 0.299258333 1.27315938 0.56837434
cg05362516 IRX5 10265 1.72746 0.085273145 0.299260828 1.25176309 0.54180113 cgl7015234 RABL2A 11159 1.72725 0.085310941 0.299304586 1.26077894 0.55612142 cg09325711 RALA 5898 1.72721 0.085316938 0.299304586 1.25769307 0.55465914 cg26007077 SNAPC3 6619 1.72704 0.085347372 0.299304586 1.2623964 0.55566761 cg04220579 C7orf20 51608 -1.72696 0.085363361 0.299304586 0.7905864 0.56711376 cg26365854 ALX4 60529 1.72685 0.085383156 0.299304586 1.27094763 0.55536507 cg00848461 RAB24 53917 -1.72678 0.085394576 0.299304586 0.78699774 0.54190198 cgl2130692 EPM2A 7957 1.72678 0.085395175 0.299304586 1.27515097 0.56065954 cg21634602 APC 324 1.72665 0.085418923 0.29933296 1.27570587 0.54896128 cgl8864581 ZWILCH 55055 1.7264 0.085463797 0.299382298 1.26672456 0.56519766 cg07214572 LHX9 56956 1.72639 0.085464314 0.299382298 1.26189509 0.57462687 cg05200606 CCND1 595 - 1.7262 0.085499589 0.299451013 0.78501425 0.59640984 cg02582754 MAS1 4142 -1 .72599 0.085537009 0.299514455 0.78055454 0.55405405 cgl3722123 GRM1 2911 1 .72592 0.085549028 0.299514455 1.26211809 0.56958451 cg04567315 CLUL1 27098 1 .72571 0.085587409 0.29959398 1.27014167 0.56817265 cgl3282594 BGLAP 632 -1 .72555 0.085616607 0.299601221 0.79584768 0.5428096 cg05232067 BNIP3L 665 1 .72553 0.085620812 0.299601221 1.26165121 0.56393707 cg25671651 WDR12 55759 1 .72516 0.085686584 0.299772745 1.26405723 0.55264219 cg25177452 PRP2 134285 1 .72508 0.085701183 0.299772745 1.26425871 0.56429004 cg09082287 DNAJC6 9829 1 .72496 0.085722588 0.299783678 1.26800272 0.56711376 cgl5559737 CRYBA4 1413 -1 .72475 0.085761638 0.299783678 0.78875133 0.57775313 cgl5698196 CAPN12 147968 1 .72469 0.085771648 0.299783678 1.26023969 0.556071 cg08797194 UGCGL2 55757 1 .72467 0.085774957 0.299783678 1.27340803 0.56640783 cgl5836394 FDFT1 2222 -1 .72458 0.085791026 0.299783678 0.79020366 0.55294474 cg27187881 NAGA 4668 1 .72454 0.085798369 0.299783678 1.26476597 0.56847519 cgl7142183 IL1R2 7850 1 .72429 0.085844807 0.29981918 1.26307393 0.56045785 cg09571369 P2RY14 9934 1 .72425 0.085851446 0.29981918 1.25875859 0.57523195 cg23983340 CD46 4179 1 .72423 0.085855565 0.29981918 1.26271701 0.5393808 cg26803305 SLC14A1 6563 1 .72387 0.085920739 0.29985009 1.26403626 0.52599334 cg00795268 Cllorf55 399879 -1 .72383 0.08592708 0.29985009 0.79228265 0.54286002 cgl7965019 HIST1 H3J 8356 1 .72378 0.08593621 0.29985009 1.26598909 0.56918112 cg22396129 ZCRB1 85437 1 .72376 0.085939412 0.29985009 1.260528 0.54371723 cg05798712 FABP7 2173 -1 .72372 0.085947075 0.29985009 0.7873004 0.55173457 cg22155248 TAPBPL 55080 1 .72366 0.085958497 0.29985009 1.26669877 0.55007059

Claims

1. A method for predicting the risk in a subject of developing cancer, the method comprising:
a) assessing in a sample of genomic DNA from said subject the methylation status of one or more genes selected from a target gene of NIPP1, MSX1 or NANOG, a polycomb group target gene (PCGT) or a gene with an AACTTT promoter motif; and;
b) predicting the subject's risk of developing cancer based on said methylation status.
2. The method according to claim 1 wherein said cancer is breast cancer.
3. The method according to claim 2 wherein said one or more genes are selected from the genes shown in Table 2.
4. The method according to any preceding claim wherein said one or more genes are required for the differentiation of stem or progenitor cells
5. The method according to claim 4 wherein said stem or progenitor cells are in breast tissue.
6. The method according to any preceding claim wherein the risk of cancer is predicted in advance of the onset of signs or clinical symptoms of cancer.
7. The method according to claim 6 wherein the risk of cancer is predicted at least 2, 3, 4 or 5 years in advance of the onset of signs or clinical symptoms of cancer.
8. The method according to any preceding claim wherein the risk of cancer is predicted up to 5 years in advance of the onset of signs or clinical symptoms of cancer.
9. The method according to any preceding claim wherein said sample of genomic DNA is obtained from serum, peripheral blood cells, or buccal, cervical or vaginal epithelia.
10. The method according to any preceding claim wherein the methylation status of one or more PCGT genes is assessed.
11. The method according to claim 10 wherein the methylation status of five or more PCGT genes selected from Table 2 is assessed.
12. The method according to any preceding claim wherein assessment of
methylation status involves an assessment of hypermethylation, wherein said hypermethylation is predictive of a risk of developing breast cancer.
13. The method according to any preceding claim wherein assessment of
methylation status involves assessing the methylation of one or more CpG sites in each gene.
14. The method according to claim 13 wherein the methylation of one or more CpG sites in the promoter or regulatory region of each gene is assessed.
15. The method according to any preceding claim wherein the subject is a human subject.
16. The method according to any preceding claim wherein the risk of developing breast cancer in step b) is predicted based on both the methylation status and the presence or absence of one or more single nucleotide polymorphisms (SNPs) associated with a risk of developing breast cancer.
17. The method according to any preceding claim wherein the risk of developing breast cancer in step b) is predicted based additionally on the assessment of traditional risk factors of breast cancer.
18. The method according to any preceding claim wherein the assessment of
methylation status of said one or more genes in step b) involves use of a microarray on which one or more CpG sites from a plurality of genes selected from Table 1 are bound.
19. A method for selecting a subject suitable for preventative treatment of cancer, the method comprising:
a) predicting the subject's risk of developing cancer according to any preceding claim; and
b) selecting a subject for preventative treatment of cancer based on the level of risk predicted
20. The method of claim 19 further comprising carrying out preventative treatment for cancer.
21. The method of claim 20 wherein said preventative treatment comprises surgical intervention, increased screening programs and/or administration of a pharmaceutically active compound.
22. The method according to any preceding claim wherein the risk of death of said subject from said cancer is predicted.
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