WO2012100913A1 - Dispositif à fixer sur ou dans l'oreille pour la stimulation nerveuse transcutanée - Google Patents

Dispositif à fixer sur ou dans l'oreille pour la stimulation nerveuse transcutanée Download PDF

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Publication number
WO2012100913A1
WO2012100913A1 PCT/EP2012/000136 EP2012000136W WO2012100913A1 WO 2012100913 A1 WO2012100913 A1 WO 2012100913A1 EP 2012000136 W EP2012000136 W EP 2012000136W WO 2012100913 A1 WO2012100913 A1 WO 2012100913A1
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WO
WIPO (PCT)
Prior art keywords
stimulation
electrode
bow
spring element
nerve
Prior art date
Application number
PCT/EP2012/000136
Other languages
German (de)
English (en)
Inventor
Wolf Gerhard Frenkel
Andreas Hartlep
Christoph Beck
Original Assignee
Cerbomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerbomed Gmbh filed Critical Cerbomed Gmbh
Publication of WO2012100913A1 publication Critical patent/WO2012100913A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36031—Control systems using physiological parameters for adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters

Definitions

  • the invention relates to a device for transcutaneous stimulation of a nerve of the human body, which has at least one stimulation electrode and at least one reference electrode for transcutaneous nerve stimulation, wherein the at least one stimulation electrode and the at least one reference electrode are connected to a control unit and from this with an electric current wherein the at least one stimulation electrode and the at least one reference electrode are arranged in or on a housing, which is designed for attachment to or in the human ear, wherein the housing has a bow-shaped extension which is designed for insertion into the auditory canal, wherein the bow-shaped extension of the shape of the auditory canal entrance and the external auditory canal is modeled and wherein at the end of the bow-shaped extension an electrode head is arranged, the at least two contact points for the mind at least two electrodes.
  • Electrodes of the generic type are known in many ways.
  • a transcutaneous nerve and muscle stimulation is used, for example, in sports medicine for stimulating a muscle, for this purpose
  • Electrodes are placed on the skin or glued on.
  • the advantage is that there is no trauma to the skin surface when the electrode is placed in position (non-invasive application of the electrode). This is also faced with previously known possibilities in which electrodes are implanted in or under the skin.
  • invasive vagus nerve stimulation is now regarded as an established therapy method in neurology for the treatment of epilepsy, for example on Penry JK, Dean JC: Prevention of intractable partial seizures by intermittent vagal stimulation in humans: preliminary results.
  • the patient is surgically exposed to the neurosurgical in the left neck area of the vagus nerve and wrapped with a current conductor as an electrode.
  • the device for current pulse generation is implanted under the skin in the left shoulder area.
  • the vagus nerve stimulator can later be programmed externally by means of an electromagnetic field.
  • the electrical vagus nerve stimulation stimulates the brain in different areas, which can be demonstrated in imaging procedures.
  • the stimulation treatment also leads to mental effects, eg. B. to antidepressant effects, s.
  • the US 5,458,625 shows a device of the type mentioned for nerve stimulation by means of electrical impulses.
  • the current pulses are introduced by means of electrodes which are attached to the earlobe of the patient.
  • EP 0 645 162 B l describes a stimulation device for the stimulation of muscles and nerves, which comprises a function generator for generating a waveform with a sequence of pulses. It is especially intended for pain therapy.
  • EP 0 757 573 A1 and EP 1 064 047 A I describe systems and methods for electrical nerve stimulation in general.
  • EP 1 145 736 A2 proposes an implantable, multimodal neurostimulator.
  • EP 0972 538 A2 describes a system for delivering electrical stimulation to a part of the nervous system by means of a needle electrode.
  • EP 1 048 319 A2 discloses a system for the selective activation of brain neurons, spinal parenchyma or peripheral nerves operating with an introducer cannula.
  • EP 1 022 034 A1 describes a method and a device for stimulating muscles or nerve tissue by generating pulse signals.
  • EP 1 393 773 A1 describes an external nerve stimulator of the phrenic nerve by means of an oesophageal electrode.
  • EP 0 962 234 A1 describes a device for electrical nerve stimulation, wherein a placement of the electrodes is not disclosed.
  • WO 97/45160 describes a device for the modulation of neural brain plasticity.
  • EP 1 420 854 A2 uses a diaphragmatic electrode for the treatment of neuropsychiatric disorders.
  • EP 1 418 981 A1 stimulates nerves in the vicinity of the diaphragm to treat movement disorders.
  • the following circumstances have proven disadvantageous:
  • the stimulation device must be removed with the same risks as described above.
  • the feeling of being delivered to a machine implanted in the body and not be able to easily get rid of this when needed.
  • the devices described often have a large, unwieldy construction and are therefore suitable only for clinical use but not for domestic long-term stimulation.
  • the stimulation device and electrodes are often connected by longer cables, which has a detrimental effect on handling.
  • stimulation can only take place at a fixed berth, but not inconspicuously and not disturbing when performing daily work.
  • the invention is therefore based on the object, a device of the type mentioned in such a way that this desire is satisfied.
  • a device for nerve stimulation is to be created which enables a particularly efficient and simple stimulation of the vagus nerve in everyday life and in a simple and virtually invisible manner.
  • the device should be applicable to the patient in a particularly simple manner and in particular make it possible, if necessary, to be able to be removed quickly from the body.
  • An efficient external, non-invasive device for the stimulation of the vagus parts should be proposed, which is characterized by a high wearing comfort, whereby the stimulation should be possible at any time and uncomplicated.
  • the patient is given the opportunity to control the therapy become.
  • the device should turn off a simple, stable and safe stimulation method.
  • the bow-shaped extension is formed as an intrinsically stiff element, wherein it is a spring element or comprises a spring element for generating an elastic contact force for contacting the electrode head to a Section is formed, in particular on a surface region of the ear canal.
  • the spring element preferably extends along at least part of the extension of the bow-shaped extension.
  • the spring element consists of a shape memory material which assumes a predetermined shape when a predetermined temperature is reached.
  • the spring element consists preferably of metallic alloys of nickel-titanium (NiTi), copper-zinc (CuZn), copper-zinc-aluminum (CoZnAl), copper-zinc-nickel (CuZnNi), iron-nickel-aluminum (FeNiAl) or from a shape memory polymer.
  • the use of said shape-memory material affords the advantage that a fit-fitting insertion of an otoplastic into the ear is thereby considerably simplified.
  • the bow-shaped extension can be bent into a position in which a problem-free insertion of the stimulation device in the ear is possible.
  • the spring element placed in the ear warms up by the body heat, it takes the original form and thus creates optimal investment conditions in the ear.
  • the insertion of the ear into the ear is so essential especially if the user does not have sufficient fine motor skills (eg old people); the optimal fit of the earmold in the ear is ensured in each case.
  • the spring element is a spring wire.
  • the spring element can run concentrically in the bow-shaped extension.
  • the spring element is encased by the material of the bow-shaped extension. But it is also possible that the spring element is attached to one side of the bow-shaped extension.
  • a spring element made of spring steel it can be provided that the pretensioning force of the spring element is kept adjustable. This adjustment can be created for example by telescopically telescoping parts of the spring element. It is also possible to connect two spring elements by two sliding sleeves together so that the extension over which the two spring elements extend parallel to each other, is adjustable (like a bed slatted frame). About the setting of the parallel effective length of the two spring elements, the stiffness can then be adjusted by appropriate positioning of the sliding sleeves.
  • the device for stimulating the vagus nerve in the region of the external auditory canal and / or the auricle is designed and suitable.
  • control unit is arranged in the housing. But it can also be provided that the control unit is removable from the housing and is in communication with the electrodes.
  • the connection can be a Be wire connection; but it is also possible a wireless connection, such as a wireless connection.
  • the electrode head is advantageously made of a soft material, in particular soft silicone.
  • the contact points can be formed by metal balls. They can also be formed by flat surface electrodes. Furthermore, it is possible that the contact points are formed by an element made of a material with electrical surface conductivity, in particular a sponge with graphite inclusions.
  • the control unit may be suitable for influencing the frequency of an alternating current flowing through the electrodes. The same applies to the influence of the height of the current flowing through the electrodes, for influencing the length of pulses of the current flowing through the electrodes, for influencing temporal stimulation intervals of the current flowing through the electrodes and / or for influencing the time course of the through the electrodes flowing current.
  • a rechargeable battery is arranged in the device, which supplies power to the control unit.
  • the device has a sensor for measuring a physiological parameter of the patient. This may be, for example, the pulse of the patient or the oxygen saturation of the blood of the patient.
  • a memory chip for storing the data measured by means of the sensor can be provided.
  • the electrodes can be integrated in the earpiece or in the headphones of a mobile phone handsfree device and the control unit can be integrated into a mobile phone. It can be provided that the connection between the electrodes and the control unit via a radio link, in particular via a blue-tooth connection or a WLAN connection takes place.
  • the electrodes are integrated in the headphones of a music playback device and that the control unit is integrated in the music playback device.
  • vagus nerve stimulation is also possible through the skin of the ear and thus non-invasively by means of a transcutaneous electrode. It has already been proven that an electrical stimulation of the vagus nerve via afferents in the external auditory canal leads to a derivable potential on the cranial surface (sensory evoked potential). The proposed concept thus stimulates the nerve branches (ramus auricular nerve) of the vagus nerve, which extend in the area of the external auditory canal, and thus influence their function. This is achieved by integrating the technique of transcutaneous vagus nerve stimulation into a stimulation device to be worn on or behind the ear, which is similar in appearance to a hearing aid.
  • External (non-invasive) stimulation units for the vagus nerve in the ear area did not exist so far.
  • the invention provides a remedy.
  • the previously known non-invasive nerve stimulation method by means of Current applications are used for peripheral nerve and muscle stimulation for pain therapy (transcutaneous electrical nerve stimulation - TENS), for muscle training (electrical muscle stimulation - EMS) or for electroacupuncture of certain meridian points. None of these procedures are designed to stimulate the vagus nerve in the ear area to induce changes in the central nervous system.
  • the invention relies on transcutaneous vagus nerve stimulation in the ear area and proposes a particularly simple device for this purpose.
  • a transcutaneous stimulation of the vagus nerve in particular for the treatment of neuropsychiatric disorders possible, with a placed in or on the external auditory canal stimulation electrode for transcutaneous stimulation of the auricular branch of the vagus nerve and a placed in or on the external auditory canal reference electrode is provided preferably connected to a control unit which is worn on or behind the ear.
  • the electrodes touch the skin surface of the external ear canal and can thus stimulate the vagus nerve parts located there.
  • a defined biasing force of the arcuate extension or of the electrode head located at its end is exerted on a part of the auditory canal.
  • a shape memory alloy metal or polymer material used for the spring element, it can be achieved, for example, that z. B. at 28 ° C, the deformation of the spring material in a predetermined shape which is impressed on the spring element, takes place, so that gradually forms the desired defined bias after insertion of the electrode head into the ear canal and so the electrode head is brought into safe working position.
  • FIG. 1 shows schematically the circuit diagram of a device for transcutaneous
  • FIG. 2 shows the stimulation device, designed as a BTE (behind-the-ear)
  • Fig. 1 the circuit diagram of a device 1 for transcutaneous vagus nerve stimulation is sketched.
  • the auricular branch is stimulated to influence psycho-vegetative parameters.
  • psycho-vegetative parameters can reduce the stress or it can be positively influenced depression or other neuropsychiatric disorders.
  • the device 1 basically consists of the stimulation electrode unit 1 1 (shown dashed on the left in FIG. 1) and of the control unit 4 (shown dashed in the right in FIG. 1).
  • the nerve is stimulated via the stimulation electrode 2.
  • the reference electrode 3 serves as the electrical reference point. Both electrodes 2, 3 form the stimulation electrode unit 1 1. Electrodes 2 and 3 Transcutaneous stimulation is known, commercially available or easy to manufacture.
  • the stimulation frequency and the stimulation intensity are predetermined and generated by the control unit 4.
  • the settings of these parameters are made via various controls 12.
  • transcutaneous stimulation oscillating signals are needed. These are generated by an oscillator 13 located in the control unit 4.
  • a logic and control circuit 14 the processing of the input and output signals, which are supplied via an input or output circuit 15 of the stimulation electrode unit 1 1 takes place.
  • the power supply is taken over by a battery 10.
  • the device 1 is similar in construction to a hearing aid worn behind the ear and has a housing 5.
  • the stimulation electrode unit in the form of an electrode head or an ear electrode 7 is introduced into the external auditory canal, so that the stimulation electrode 2 and the reference electrode 3 come to rest on the skin surface.
  • the connection between the electrode head 7 and the portion of the housing 5 shown on the left in Fig. 2 is formed as a bow-shaped extension 6, which also leads the entire supply and discharge lines between stimulation electrode unit and control unit; the bow-shaped extension 6 is placed over the upper edge of the auricle.
  • the control unit 4 is in the housing 5 with an approximate size of 5 cm x 2 cm x 1 cm.
  • the bow-shaped extension 6 in this case has a coaxially extending in it spring element 20. It consists of a shape memory alloy. If the bow-shaped extension 6 inserted into the ear canal, it heats up due the body temperature.
  • the material of the spring element eg of an alloy of nickel and titanium - "nitinol" is chosen so that at about 28 ° C, the spring element returns to its original shape, which is impressed him, so that on the Electrode head 7 is applied a gentle biasing force, which so gradually applied to the desired part of the ear canal and presses.
  • a stimulation intensity regulator 16 for controlling the amplitude (strength) of the stimulation signal. Large amplitudes stimulate the nerve more than low amplitudes. In addition, the required stimulation intensity varies between individuals.
  • a pacing frequency regulator 17 is included for controlling the frequency pattern of the stimulation signal.
  • a battery compartment 19 serves to accommodate a small button cell battery, preferably of the size 13 to 675.
  • the applied current is between 0.25 and 1.5 mA.
  • the frequency of the current is between 20 and 30 Hz.
  • the pulse width is between 250 and 500 ⁇ 5.
  • the current is given every 3 to 5 minutes for about 30 sec.
  • the proposed stimulation device 1 is very small and is therefore ideal for home use. It gives the wearer a big one Freedom, because placement behind the ear is very beneficial and not disturbing.
  • the stimulation and reference electrodes 2, 3 must be in electrical contact with the skin surface of the patient, using pads 8 and 9, respectively, which may be formed as metallic beads.
  • the electrodes 2, 3 lie on the inside of the tragus, d. H. an anatomical part of the auricle.
  • the distance between the contact points 8, 9 is preferably between 1 mm and 15 mm, more preferably between 2 mm and 6 mm.
  • the electrodes 2, 3 z. B be formed as a flat surface electrodes. Deeper in the auditory canal, more nerve endings of the vagus nerve are stimulated.
  • the electrodes 2, 3 are connected to cables (not shown), which are guided invisibly in the ear piece.
  • the cable connections in turn are connected to the preferably located behind the ear control unit 4.
  • the connection is made, as explained, via the bow-shaped extension 6.
  • the setting of the stimulation frequency, the stimulation intensity, the pulse duration and the stimulation intervals and the current form takes place via the pacing frequency regulator 17.
  • the entire technique can also be integrated in a device which lies in the concha of the ear and fills it.
  • the device is powered by the battery 10 and is thus independent of an external power source. It can be provided that the power is supplied via a rechargeable battery 10, which is integrated in the housing 5.
  • the device 1 is placed in a special box, which is connected to an external power source and, for example, via induction charges the battery 10 overnight.
  • the ear piece may additionally be provided with a sensor for measuring the pulse and the oxygen saturation, whereby such sensors for the measurement of the respiratory function and the pulse are known and commercially available.
  • the measured values can be recorded on a memory chip, which is located in the housing 5 behind or in the ear, for later reading out by a physician via a wireless interface and to be able to evaluate by software.
  • the physician can obtain important information about the psychovegetative modulation effect of the stimulation device and thus also receives control data on the course of the therapy.
  • the described device can be made in its design according to standard values, or the ear piece and other parts can be made individually.
  • An alternative embodiment provides that the electrode head 7 and the control unit 4 are kept separate and connected via a cable.
  • the control unit 4 and its electronics can in this case in the circuits be integrated in the mobile phone.
  • the stimulation unit 7 with stimulation and reference electrode 2, 3 can be installed in the ear piece of the hands-free device.
  • the communication between earpiece and mobile phone can be done both wirelessly, for example by means of Bluetooth technology, or via a connecting cable.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Electrotherapy Devices (AREA)

Abstract

L'invention concerne un dispositif (1) de stimulation nerveuse transcutanée du corps humain, comprenant au moins une électrode de stimulation (2) et au moins une électrode de référence (3) pour la stimulation nerveuse transcutanée, la au moins une électrode de stimulation (2) et la au moins une électrode de référence (3) étant en liaison avec une unité de commande (4) et pouvant être sollicitées par celle-ci au moyen d'un courant électrique, la au moins une électrode de stimulation (2) et la au moins une électrode de référence (3) étant disposées dans ou sur un boîtier (5) dont la forme permet la fixation dans ou sur l'oreille humaine, le boîtier (5) présentant un appendice (6) en forme d'étrier conçu pour être inséré dans le canal auditif, l'appendice (6) en forme d'étrier imitant la forme de l'entrée du canal auditif ou du canal auditif externe, une tête d'électrode (7) pourvue d'au moins deux contacts (8, 9) pour les au moins deux électrodes (2, 3) étant disposée à l'extrémité de l'appendice (6) en forme d'étrier. Pour allier un fonctionnement fiable à un confort élevé, l'appendice (6) en forme d'étrier selon l'invention est présente une rigidité propre, ledit appendice étant un élément élastique (20) ou comprenant un élément de ce type qui est conçu pour générer une force de contact élastique afin de mettre la tête d'électrode (7) en appui contre une section du canal auditif.
PCT/EP2012/000136 2011-01-26 2012-01-13 Dispositif à fixer sur ou dans l'oreille pour la stimulation nerveuse transcutanée WO2012100913A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011009528A DE102011009528B4 (de) 2011-01-26 2011-01-26 Vorrichtung zur transkutanen Stimulation eines Nervs des menschlichen Körpers
DE102011009528.4 2011-01-26

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WO2012100913A1 true WO2012100913A1 (fr) 2012-08-02

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WO (1) WO2012100913A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014010882A1 (de) * 2014-07-27 2016-01-28 Cerbomed Gmbh Vorrichtung zur Aufbringung eines transkutanen elektrischen Stimulationsreizes
DE102021102401A1 (de) * 2021-02-02 2022-08-04 Tvns Technologies Gmbh Gerät zur Durchführung einer tVNS-Behandlung

Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3918329A1 (de) 1989-06-05 1990-12-06 Hortmann Gmbh Hoergeraet zur elektrischen reizung des innenohres
FR2717699A1 (fr) 1994-03-24 1995-09-29 Hegoburu Pierre Appareil d'acupuncture et de massage électronique à défilement séquentiel d'impulsions, à volonté asynchrone ou synchrone du rythme cardiaque, activant des électrodes.
US5458625A (en) 1994-05-04 1995-10-17 Kendall; Donald E. Transcutaneous nerve stimulation device and method for using same
EP0757573A1 (fr) 1993-12-27 1997-02-12 Horst Edgar Krause Procede d'electrostimulation
WO1997045160A1 (fr) 1996-05-31 1997-12-04 Southern Illinois University Procedes de modulation de la plasticite neurale du cerveau par stimulation du nerf vague
JPH10108913A (ja) 1996-08-09 1998-04-28 Asahi Denshi Kenkyusho:Kk ツボ刺激装置
EP0962234A1 (fr) 1998-06-05 1999-12-08 Pierenkemper GmbH Appareil de stimulation électrique transcutanée des nerfs et des muscles
EP0972538A2 (fr) 1998-07-13 2000-01-19 Medtronic, Inc. Système fournissant une stimulation électrique à une partie du système nerveux
EP0645162B1 (fr) 1993-09-29 2000-04-05 Tech Pulse (Proprietary) Limited Appareil pour la stimulation des nerfs
EP1022034A1 (fr) 1999-01-19 2000-07-26 Manfred Dr. Leubner Procédé et dispositif pour la stimulation des muscles ou des tissus nerveux
EP1048319A2 (fr) 1999-04-30 2000-11-02 Medtronic, Inc. Système d'activation sélective des neurones du cerveau, du parenchyme de l'épine dorsale ou des nerfs périphériques
EP1064047A1 (fr) 1998-03-18 2001-01-03 Urosurge, Inc. Procedes et systemes de neurostimulateur electrique
WO2001000273A1 (fr) 1999-06-25 2001-01-04 Emory University Dispositifs et methodes de stimulation du nerf vague
EP1145736A2 (fr) 2000-04-05 2001-10-17 Neuropace, Inc. Stimulateur multimodal
EP1393773A1 (fr) 2002-08-28 2004-03-03 Siemens-Elema AB Dispositif de la stimulation des nerfs
EP1418981A1 (fr) 2001-07-28 2004-05-19 Cyberonics, Inc. Traitement de troubles de la motricite par stimulation du nerf proche du diaphragme
EP1420854A2 (fr) 2001-07-28 2004-05-26 Cyberonics, Inc. Traitement de troubles neuropsychiatriques par stimulation nerveuse a proximite du diaphragme
US20050165460A1 (en) * 2004-01-26 2005-07-28 Onje' Erfan Neuro-Electric-Therapy Headset
DE102006023824A1 (de) * 2006-05-20 2007-11-22 Cerbomed Gmbh Vorrichtung zur transkutanen Aufbringung eines Reizes oder zur transkutanen Erfassung eines Parameters
US20100057154A1 (en) * 2006-01-21 2010-03-04 Cerbomed Gmbh Device and method for the transdermal stimulation of a nerve of the human body
US20100222639A1 (en) * 2006-07-27 2010-09-02 Cochlear Limited Hearing device having a non-occluding in the canal vibrating component

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005003735B4 (de) * 2005-01-26 2008-04-03 Cerbomed Gmbh Vorrichtung zur transkutanen Stimulation eines Nervs des menschlichen Körpers

Patent Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3918329A1 (de) 1989-06-05 1990-12-06 Hortmann Gmbh Hoergeraet zur elektrischen reizung des innenohres
EP0645162B1 (fr) 1993-09-29 2000-04-05 Tech Pulse (Proprietary) Limited Appareil pour la stimulation des nerfs
EP0757573A1 (fr) 1993-12-27 1997-02-12 Horst Edgar Krause Procede d'electrostimulation
FR2717699A1 (fr) 1994-03-24 1995-09-29 Hegoburu Pierre Appareil d'acupuncture et de massage électronique à défilement séquentiel d'impulsions, à volonté asynchrone ou synchrone du rythme cardiaque, activant des électrodes.
US5458625A (en) 1994-05-04 1995-10-17 Kendall; Donald E. Transcutaneous nerve stimulation device and method for using same
WO1997045160A1 (fr) 1996-05-31 1997-12-04 Southern Illinois University Procedes de modulation de la plasticite neurale du cerveau par stimulation du nerf vague
JPH10108913A (ja) 1996-08-09 1998-04-28 Asahi Denshi Kenkyusho:Kk ツボ刺激装置
EP1064047A1 (fr) 1998-03-18 2001-01-03 Urosurge, Inc. Procedes et systemes de neurostimulateur electrique
EP0962234A1 (fr) 1998-06-05 1999-12-08 Pierenkemper GmbH Appareil de stimulation électrique transcutanée des nerfs et des muscles
EP0972538A2 (fr) 1998-07-13 2000-01-19 Medtronic, Inc. Système fournissant une stimulation électrique à une partie du système nerveux
EP1022034A1 (fr) 1999-01-19 2000-07-26 Manfred Dr. Leubner Procédé et dispositif pour la stimulation des muscles ou des tissus nerveux
EP1048319A2 (fr) 1999-04-30 2000-11-02 Medtronic, Inc. Système d'activation sélective des neurones du cerveau, du parenchyme de l'épine dorsale ou des nerfs périphériques
WO2001000273A1 (fr) 1999-06-25 2001-01-04 Emory University Dispositifs et methodes de stimulation du nerf vague
EP1145736A2 (fr) 2000-04-05 2001-10-17 Neuropace, Inc. Stimulateur multimodal
EP1418981A1 (fr) 2001-07-28 2004-05-19 Cyberonics, Inc. Traitement de troubles de la motricite par stimulation du nerf proche du diaphragme
EP1420854A2 (fr) 2001-07-28 2004-05-26 Cyberonics, Inc. Traitement de troubles neuropsychiatriques par stimulation nerveuse a proximite du diaphragme
EP1393773A1 (fr) 2002-08-28 2004-03-03 Siemens-Elema AB Dispositif de la stimulation des nerfs
US20050165460A1 (en) * 2004-01-26 2005-07-28 Onje' Erfan Neuro-Electric-Therapy Headset
US20100057154A1 (en) * 2006-01-21 2010-03-04 Cerbomed Gmbh Device and method for the transdermal stimulation of a nerve of the human body
DE102006023824A1 (de) * 2006-05-20 2007-11-22 Cerbomed Gmbh Vorrichtung zur transkutanen Aufbringung eines Reizes oder zur transkutanen Erfassung eines Parameters
US20100222639A1 (en) * 2006-07-27 2010-09-02 Cochlear Limited Hearing device having a non-occluding in the canal vibrating component

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CARPENTER LL; FRIEHS GM; PRICE LH: "Cervical vagus nerve stimulation for treatment-resistant depression", NEUROSURG CLIN N AM, vol. 14, 2003, pages 275 - 282
ELGER G; HOPPE C; FALKAI P; RUSH AJ; ELGER CE: "Vagus nerve stimulation is associated with mood improvements in epilepsy patients", EPILEPSY RES, vol. 42, 2000, pages 203 - 210
EPILEPSIA, vol. 31, no. 2, 1990, pages 40 - 43
GOODNICK PJ; RUSH AJ; GEORGE MS; MARANGELL LB; SACKEIM HA: "Vagus nerve stimulation in depression", EXPERT OPIN PHARMACOTHER, vol. 2, 2001, pages 1061 - 1063
RUSH AJ; GEORGE MS; SACKEIM HA; MARANGELL LB; HUSAIN MM; GILLER C; NAHAS Z; HAINES S; SIMPSON RK, JR.; GOODMAN R: "Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study", BIOL PSYCHIATRY, vol. 47, 2000, pages 276 - 286, XP008155848, DOI: doi:10.1016/S0006-3223(99)00304-2
UTHMAN BM; WILDER BJ; HAMMOND EJ; REID SA: "Efficacy and safety of vagus nerve stimulation in patients with complex partial seizures", EPILEPSIA, vol. 31, no. 2, 1990, pages 44 - 50

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