WO2012099441A3 - Composition inhibant une réponse immunitaire contenant des cellules souches exprimant les gènes d'une enzyme métabolisant le tryptophane - Google Patents

Composition inhibant une réponse immunitaire contenant des cellules souches exprimant les gènes d'une enzyme métabolisant le tryptophane Download PDF

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WO2012099441A3
WO2012099441A3 PCT/KR2012/000556 KR2012000556W WO2012099441A3 WO 2012099441 A3 WO2012099441 A3 WO 2012099441A3 KR 2012000556 W KR2012000556 W KR 2012000556W WO 2012099441 A3 WO2012099441 A3 WO 2012099441A3
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stem cells
mesenchymal stem
expressed
inhibiting composition
cells expressing
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PCT/KR2012/000556
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English (en)
Korean (ko)
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WO2012099441A2 (fr
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서수길
이영숙
박세광
최일환
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인제대학교산학협력단
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Priority claimed from KR1020120006704A external-priority patent/KR20120085209A/ko
Publication of WO2012099441A2 publication Critical patent/WO2012099441A2/fr
Publication of WO2012099441A3 publication Critical patent/WO2012099441A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des cellules souches mésenchymateuses exprimant les gènes d'une enzyme métabolisant le tryptophane, et une composition inhibant une réponse immunitaire comprenant celles-ci. Plus particulièrement, la kynurénine-3-hydroxylase et la kynuréninase, qui sont des enzymes métabolisant le tryptophane qui ne sont pas exprimées de manière naturelle dans les cellules souches mésenchymateuses, sont ici exprimées dans les cellules souches mésenchymateuses, afin d'inhiber de manière efficace les lymphocytes T réagissant avec les alloantigènes des cellules souches mésenchymateuses et afin d'augmenter ainsi les effets immunosuppresseurs. Les cellules souches mésenchymateuses dans lesquelles sont exprimées la kynurénine-3-hydroxylase et la kynuréninase peuvent apporter de meilleurs effets immunosuppresseurs que les cellules souches mésenchymateuses dans lesquelles ces enzymes ne sont pas exprimées, et par conséquent, peuvent prévenir et traiter de manière efficace les maladies provoquées par une hyperactivation des lymphocytes T, notamment des maladies du greffon contre l'hôte.
PCT/KR2012/000556 2011-01-21 2012-01-20 Composition inhibant une réponse immunitaire contenant des cellules souches exprimant les gènes d'une enzyme métabolisant le tryptophane WO2012099441A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2011-0006306 2011-01-21
KR20110006306 2011-01-21
KR10-2012-0006704 2012-01-20
KR1020120006704A KR20120085209A (ko) 2011-01-21 2012-01-20 트립토판 대사효소 유전자를 발현하는 줄기세포를 함유하는 면역 반응 억제용 조성물

Publications (2)

Publication Number Publication Date
WO2012099441A2 WO2012099441A2 (fr) 2012-07-26
WO2012099441A3 true WO2012099441A3 (fr) 2012-10-18

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PCT/KR2012/000556 WO2012099441A2 (fr) 2011-01-21 2012-01-20 Composition inhibant une réponse immunitaire contenant des cellules souches exprimant les gènes d'une enzyme métabolisant le tryptophane

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016004095A2 (pt) * 2013-08-30 2017-10-17 Univ Texas administração de enzimas de empobrecimento de quinurenina para a terapia contra tumores
IL250833B (en) 2014-08-29 2022-09-01 Univ Texas Administering enzymes to reduce the level of kynurenine in the treatment of tumors
WO2016117960A1 (fr) * 2015-01-23 2016-07-28 가톨릭대학교 산학협력단 Cellules souches mésenchymateuses surexprimées par grim19 efficaces dans le traitement d'une maladie immunitaire, et leur utilisation
KR101739659B1 (ko) * 2015-01-23 2017-05-24 가톨릭대학교 산학협력단 면역질환 치료 효능을 갖는 Ｇｒｉｍ１９이 과발현된 중간엽줄기세포 및 이의 용도
EP3423483A4 (fr) 2016-03-02 2019-08-21 Board Of Regents Of the University Of Texas System Variants de l'enzyme kynuréninase humaine ayant des propriétés pharmacologiques améliorées
KR20200143455A (ko) 2018-04-16 2020-12-23 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 인간 키누레니나제 효소 및 이의 사용법
WO2020056410A1 (fr) * 2018-09-14 2020-03-19 The Children's Hospital Of Philadelphia Compositions et méthodes pour moduler l'immunosuppression

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
C. A. OPITZ ET AL.: "Tryptophan degradation in autoimmune diseases", CELL. MOL. LIFE SCI., vol. 64, no. 19/20, 2007, pages 2542 - 2563 *
CHRISTIANE A. OPITZ ET AL.: "Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-l via interferon-0 and protein kinase R", STEM CELLS, vol. 27, no. 4, 2009, pages 909 - 919 *
MARIOLA MATYSIAK ET AL.: "Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism", JOURNAL OFNEUROIMMUNOLOGY, vol. 193, no. 1/2, 2008, pages 12 - 23 *
SOUFIANE GHANNAM ET AL.: "Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications", STEM CELL RESEARCH & THERAPY, vol. 1, no. 1, 2, 2010, ISSN: 1757-6512, Retrieved from the Internet <URL:http://stemcellres.com/content/1/1/2> *

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