WO2012098281A3 - Peptides modulateurs de récepteurs trp et leurs utilisations - Google Patents

Peptides modulateurs de récepteurs trp et leurs utilisations Download PDF

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Publication number
WO2012098281A3
WO2012098281A3 PCT/ES2012/070026 ES2012070026W WO2012098281A3 WO 2012098281 A3 WO2012098281 A3 WO 2012098281A3 ES 2012070026 W ES2012070026 W ES 2012070026W WO 2012098281 A3 WO2012098281 A3 WO 2012098281A3
Authority
WO
WIPO (PCT)
Prior art keywords
trp
receptor
modulating peptides
peptides
illnesses
Prior art date
Application number
PCT/ES2012/070026
Other languages
English (en)
Spanish (es)
Other versions
WO2012098281A2 (fr
Inventor
Antonio Ferrer Montiel
Asia Fernández Carvajal
Gregorio FERNÁNDEZ BALLESTER
José Manuel GONZÁLEZ ROS
Carlos BELMONTE MARTÍNEZ
Pierluigi VALENTE
María CAMBPRUBI ROBLES
Félix VIANA DE LA IGLESIA
Ana GOMIS GARCÍA
Wim Van Den Nest
Cristina CARREÑO SERRAÏMA
Original Assignee
Universidad Miguel Hernández De Elche
Bcn Peptides, S.A.
Consejo Superior De Investigaciones Científicas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Miguel Hernández De Elche, Bcn Peptides, S.A., Consejo Superior De Investigaciones Científicas filed Critical Universidad Miguel Hernández De Elche
Publication of WO2012098281A2 publication Critical patent/WO2012098281A2/fr
Publication of WO2012098281A3 publication Critical patent/WO2012098281A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des peptides qui ont la capacité de moduler l'activité de récepteurs TRP et leur utilisation pour le traitement et/ou la prévention de la douleur, l'inflammation, le prurit, des maladies et/ou troubles des voies respiratoires et/ou des maladies et/ou troubles associés à des déséquilibres en calcium.
PCT/ES2012/070026 2011-01-19 2012-01-19 Peptides modulateurs de récepteurs trp et leurs utilisations WO2012098281A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP201130052 2011-01-19
ES201130052 2011-01-19

Publications (2)

Publication Number Publication Date
WO2012098281A2 WO2012098281A2 (fr) 2012-07-26
WO2012098281A3 true WO2012098281A3 (fr) 2012-11-29

Family

ID=45852574

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2012/070026 WO2012098281A2 (fr) 2011-01-19 2012-01-19 Peptides modulateurs de récepteurs trp et leurs utilisations

Country Status (1)

Country Link
WO (1) WO2012098281A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011071995A2 (fr) 2009-12-08 2011-06-16 Case Western Reserve University Composés et procédés de traitement de troubles oculaires
US9340478B2 (en) 2011-11-28 2016-05-17 Kao Corporation Cooling agent and TRPM8 activator
PT3466930T (pt) 2013-02-08 2022-08-19 Gen Mills Inc Produto alimentar com baixo teor de sódio
CA2919892C (fr) 2013-08-12 2019-06-18 Pharmaceutical Manufacturing Research Services, Inc. Comprime extrude anti-abus a liberation immediate
ES2532749B1 (es) * 2013-09-30 2016-01-15 Universidad Miguel Hernández De Elche Péptidos bloqueantes de termorreceptores y sus usos
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015095391A1 (fr) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Comprimé extrudé anti-abus à libération prolongée
US9707184B2 (en) 2014-07-17 2017-07-18 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
EP3209282A4 (fr) 2014-10-20 2018-05-23 Pharmaceutical Manufacturing Research Services, Inc. Forme galénique anti-abus de remplissage de liquide à libération prolongée
KR20200074965A (ko) 2017-10-19 2020-06-25 암젠 인크 벤즈이미다졸 유도체 및 이의 용도
CN109364050B (zh) * 2018-10-19 2021-02-02 大连医科大学 艾地苯醌在制备治疗肺动脉高压药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1179538A1 (fr) * 1999-03-23 2002-02-13 Universidad Miguel Hernandez de Elche Peptides capables de bloquer la reponse aux substances chimiques ou stimuli thermiques ou mediateurs de l'inflammation des nocicepteurs, et compositions les contenant
WO2005089206A2 (fr) * 2004-03-13 2005-09-29 Irm Llc Modulateurs du canal ionique trpa1
WO2007047127A2 (fr) * 2005-10-11 2007-04-26 Senomyx, Inc. Sequences d'acide nucleique de trpm8 optimisees et leur utilisation dans des epreuves biologiques fondees sur des cellules, et trousses d'essai pour identifier des modulateurs de trpm8
US20100137259A1 (en) * 2008-11-28 2010-06-03 Korea University Industry And Academic Collaboration Foundation Compound for inhibiting trpa1 function and use thereof

Family Cites Families (14)

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EP2275552B1 (fr) 1999-10-29 2015-09-09 GlaxoSmithKline Biologicals SA Peptides antigéniques de Neisseria
EP1290217A2 (fr) 2000-02-04 2003-03-12 Aeomica, Inc. Procedes et appareil destines a predire, a confirmer, et a afficher des informations fonctionnelles derivees d'une sequence genomique
ES2169691B1 (es) 2000-10-11 2004-03-16 Diverdrugs Sl Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen.
US7803382B2 (en) 2001-05-04 2010-09-28 Ludwig Institute For Cancer Research Ltd. Method for inducing immune response to NY-CO-58
ES2195787B1 (es) 2002-05-20 2005-06-01 Diverdrugs, S.L. Compuestos capaces de bloquear la respuesta a sustancias quimicas o estimulos termicos o mediadores de la inflamacion de los nociceptores, un metodo para su obtencion y composiciones que los continen.
US20080287398A1 (en) 2007-05-02 2008-11-20 Colburn Raymond W Cold menthol receptor-1 antagonists
SI3184527T1 (sl) 2007-06-22 2020-03-31 Eli Lilly And Company Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala
CN101959861A (zh) 2008-01-04 2011-01-26 雅培制药有限公司 Trpa1拮抗剂
US9108905B2 (en) 2008-01-04 2015-08-18 Abbvie Inc. TRPA1 antagonists
US7951814B2 (en) 2008-06-17 2011-05-31 Glenmark Pharmaceuticals, S.A. Quinazolinedione derivatives as TRPA1 modulators
WO2010103381A1 (fr) 2009-03-13 2010-09-16 Glenmark Pharmaceuticals S.A. Dérivés de pipéridine spirocycliques en tant que modulateurs de trpm8
WO2010125469A1 (fr) 2009-04-29 2010-11-04 Glenmark Pharmaceuticals, S.A. Composés hétérocycliques fusionnés à une pyrimidine dione en tant que modulateurs de trpa1
WO2010141805A1 (fr) 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Amides hétérocycliques en tant que modulateurs de la trpa1
TW201103941A (en) 2009-06-10 2011-02-01 Janssen Pharmaceutica Nv Benzimidazole derivatives useful as TRPM8 channel modulators

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1179538A1 (fr) * 1999-03-23 2002-02-13 Universidad Miguel Hernandez de Elche Peptides capables de bloquer la reponse aux substances chimiques ou stimuli thermiques ou mediateurs de l'inflammation des nocicepteurs, et compositions les contenant
WO2005089206A2 (fr) * 2004-03-13 2005-09-29 Irm Llc Modulateurs du canal ionique trpa1
WO2007047127A2 (fr) * 2005-10-11 2007-04-26 Senomyx, Inc. Sequences d'acide nucleique de trpm8 optimisees et leur utilisation dans des epreuves biologiques fondees sur des cellules, et trousses d'essai pour identifier des modulateurs de trpm8
US20100137259A1 (en) * 2008-11-28 2010-06-03 Korea University Industry And Academic Collaboration Foundation Compound for inhibiting trpa1 function and use thereof

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
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P. VALENTE ET AL: "Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I", THE FASEB JOURNAL, vol. 22, no. 9, 1 September 2008 (2008-09-01), pages 3298 - 3309, XP055028198, ISSN: 0892-6638, DOI: 10.1096/fj.08-107425 *
P. VALENTE ET AL: "Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity", THE FASEB JOURNAL, vol. 25, no. 5, 1 May 2011 (2011-05-01), pages 1628 - 1640, XP055027937, ISSN: 0892-6638, DOI: 10.1096/fj.10-174433 *
PEDRETTI A ET AL: "Comparative modeling of the quaternary structure for the human TRPM8 channel and analysis of its binding features", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 1788, no. 5, 1 May 2009 (2009-05-01), pages 973 - 982, XP026023974, ISSN: 0005-2736, [retrieved on 20090220], DOI: 10.1016/J.BBAMEM.2009.02.007 *
STUCKY C L ET AL: "Roles of transient receptor potential channels in pain", BRAIN RESEARCH REVIEWS, ELSEVIER, NL, vol. 60, no. 1, 1 April 2009 (2009-04-01), pages 2 - 23, XP026066382, ISSN: 0165-0173, [retrieved on 20081231], DOI: 10.1016/J.BRAINRESREV.2008.12.018 *
WONG G Y ET AL: "Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks", BRAIN RESEARCH REVIEWS, ELSEVIER, NL, vol. 60, no. 1, 1 April 2009 (2009-04-01), pages 267 - 277, XP026066401, ISSN: 0165-0173, [retrieved on 20090401], DOI: 10.1016/J.BRAINRESREV.2008.12.006 *

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