WO2012098143A1 - Utilisation d'inhibiteurs de canaux potassiques atp-dépendants pour le traitement de la perte d'audition - Google Patents

Utilisation d'inhibiteurs de canaux potassiques atp-dépendants pour le traitement de la perte d'audition Download PDF

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Publication number
WO2012098143A1
WO2012098143A1 PCT/EP2012/050683 EP2012050683W WO2012098143A1 WO 2012098143 A1 WO2012098143 A1 WO 2012098143A1 EP 2012050683 W EP2012050683 W EP 2012050683W WO 2012098143 A1 WO2012098143 A1 WO 2012098143A1
Authority
WO
WIPO (PCT)
Prior art keywords
atp
inhibitor
sensitive potassium
hearing loss
potassium channel
Prior art date
Application number
PCT/EP2012/050683
Other languages
English (en)
Inventor
Jochen Roeper
Silvi HOIDIS
Jean SMOLDERS
Manuel GROTH
Original Assignee
Johann Wolfgang Goethe-Universität, Frankfurt Am Main
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johann Wolfgang Goethe-Universität, Frankfurt Am Main filed Critical Johann Wolfgang Goethe-Universität, Frankfurt Am Main
Publication of WO2012098143A1 publication Critical patent/WO2012098143A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne l'utilisation d'inhibiteurs de canaux potassiques ATP-dépendants pour la thérapie protectrice (notamment préventive) ou la progression amoindrie de la perte d'audition, en particulier la perte d'audition liée à l'âge (presbyacousie) et/ou la perte d'audition induite par le bruit (NIHL). Est préférée l'administration systémique ou locale de sulfonylurées cliniquement établies, telles que, par exemple, le glibenclamide.
PCT/EP2012/050683 2011-01-18 2012-01-18 Utilisation d'inhibiteurs de canaux potassiques atp-dépendants pour le traitement de la perte d'audition WO2012098143A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1100783.8A GB2487366A (en) 2011-01-18 2011-01-18 Use of inhibitors of ATP-sensitive potassium channels for the treament of hearing loss
GB1100783.8 2011-01-18

Publications (1)

Publication Number Publication Date
WO2012098143A1 true WO2012098143A1 (fr) 2012-07-26

Family

ID=43736567

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/050683 WO2012098143A1 (fr) 2011-01-18 2012-01-18 Utilisation d'inhibiteurs de canaux potassiques atp-dépendants pour le traitement de la perte d'audition

Country Status (2)

Country Link
GB (1) GB2487366A (fr)
WO (1) WO2012098143A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10183972B2 (en) 2016-07-14 2019-01-22 University Of South Florida BK channel-modulating peptides and their use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005025293A2 (fr) 2003-09-10 2005-03-24 Icagen, Inc. Anneaux condenses heterocycliques modulateurs des canaux de potassium
US20050129783A1 (en) 2001-04-19 2005-06-16 Mccleary Edward L. Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health
US20070248690A1 (en) 2006-04-24 2007-10-25 Trager Seymour F Composition and methods for alleviating symptoms of neurotoxicity
WO2010042728A1 (fr) 2008-10-08 2010-04-15 Cornell University Modulateurs à petite molécule d'une absorption de prongf

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050129783A1 (en) 2001-04-19 2005-06-16 Mccleary Edward L. Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health
WO2005025293A2 (fr) 2003-09-10 2005-03-24 Icagen, Inc. Anneaux condenses heterocycliques modulateurs des canaux de potassium
US20070248690A1 (en) 2006-04-24 2007-10-25 Trager Seymour F Composition and methods for alleviating symptoms of neurotoxicity
WO2010042728A1 (fr) 2008-10-08 2010-04-15 Cornell University Modulateurs à petite molécule d'une absorption de prongf

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
FIERING J ET AL.: "Local drug delivery with a self-contained, programmable, microfluidic system", BIOMED MICRODEVICES, vol. 11, no. 3, June 2009 (2009-06-01), pages 571 - 8, XP019670998
HERZOG M; SCHERER EQ; ALBRECHT B; RORABAUGH B; SCOFIELD MA; WANGEMANN P.: "CGRP receptors in the gerbil spiral modiolar artery mediate a sustained vasodilation via a transient cAMP-mediated Ca2+-decrease", J MEMBR BIOL., vol. 189, no. 3, 1 October 2002 (2002-10-01), pages 225 - 36
KOCHER: "Presbycusis: Reversible with anesthesia drugs?", MEDICAL HYPOTHESES, vol. 72, 2009, pages 157 - 159, XP025837154, DOI: doi:10.1016/j.mehy.2008.09.013
LISS ET AL., NATURE NEUROSCIENCE, 2005
SHIEH CC; COGHLAN M; SULLIVAN JP: "Gopalakrishnan M Potassium channels: molecular defects, diseases, and therapeutic opportunities", PHARMACOL REV., vol. 52, no. 4, December 2000 (2000-12-01), pages 557 - 94, XP002295931
SILVERSTEIN H ET AL.: "Dexamethasone inner ear perfusion for the treatment of Meniere's disease: a prospective, randomized, double-blind, crossover trial.", AM J OTOL., vol. 19, no. 2, March 1998 (1998-03-01), pages 196 - 201
WU T; MARCUS DC.: "Age-related changes in cochlear endolymphatic potassium and potential in CD-1 and CBA/CaJ mice", J ASSOC RES OTOLARYNGOL., vol. 4, no. 3, September 2003 (2003-09-01), pages 353 - 62

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10183972B2 (en) 2016-07-14 2019-01-22 University Of South Florida BK channel-modulating peptides and their use
US11214595B2 (en) 2016-07-14 2022-01-04 University Of South Florida BK channel-modulating peptides and their use

Also Published As

Publication number Publication date
GB2487366A (en) 2012-07-25
GB201100783D0 (en) 2011-03-02

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