WO2012090073A3 - Methods and compositions for predicting chemotherapy sensitivity - Google Patents

Methods and compositions for predicting chemotherapy sensitivity Download PDF

Info

Publication number
WO2012090073A3
WO2012090073A3 PCT/IB2011/003338 IB2011003338W WO2012090073A3 WO 2012090073 A3 WO2012090073 A3 WO 2012090073A3 IB 2011003338 W IB2011003338 W IB 2011003338W WO 2012090073 A3 WO2012090073 A3 WO 2012090073A3
Authority
WO
WIPO (PCT)
Prior art keywords
patient
methods
compositions
breast cancer
chemotherapy sensitivity
Prior art date
Application number
PCT/IB2011/003338
Other languages
French (fr)
Other versions
WO2012090073A2 (en
Inventor
Sven ROTTENBERG
Jos JONKERS
Original Assignee
The Netherlands Cancer Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Netherlands Cancer Institute filed Critical The Netherlands Cancer Institute
Publication of WO2012090073A2 publication Critical patent/WO2012090073A2/en
Publication of WO2012090073A3 publication Critical patent/WO2012090073A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The instant application provides methods and related compositions pertaining to the identification of chemosensitivity in a patient. In a particular embodiment, the invention provides biomarkers for the identification of chemosensitivity in a breast cancer patient, wherein a reduced expression of an X-linked gene, such as XIST, in the breast cancer cells of the patient indicates that the breast cancer cells in the patient may be successfully treated with a platinum-based compound, such as cisplatin.
PCT/IB2011/003338 2010-12-30 2011-12-30 Methods and compositions for predicting chemotherapy sensitivity WO2012090073A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201061428674P 2010-12-30 2010-12-30
US61/428,674 2010-12-30
US201161429364P 2011-01-03 2011-01-03
US61/429,364 2011-01-03

Publications (2)

Publication Number Publication Date
WO2012090073A2 WO2012090073A2 (en) 2012-07-05
WO2012090073A3 true WO2012090073A3 (en) 2012-11-29

Family

ID=45873186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/003338 WO2012090073A2 (en) 2010-12-30 2011-12-30 Methods and compositions for predicting chemotherapy sensitivity

Country Status (1)

Country Link
WO (1) WO2012090073A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2787084A1 (en) * 2013-04-05 2014-10-08 Les Laboratoires Servier Biomarkers for the identification of chemosensitivity
RU2551232C1 (en) * 2014-07-04 2015-05-20 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Method of predicting efficiency of chemotherapy in treatment of mammary gland cancer
CN110438222B (en) * 2018-05-04 2023-08-18 中国科学院分子细胞科学卓越创新中心 Early diagnosis detection kit for invasive lymphoma
CN110438221B (en) * 2018-05-04 2023-06-06 中国科学院分子细胞科学卓越创新中心 Detection kit for predicting and evaluating curative effect of lymphoma on chemotherapeutic drugs
CN109771668A (en) * 2019-02-03 2019-05-21 隋新兵 The purposes of KDM6A gene or KDM6AmRNA
MX2024008510A (en) * 2022-01-07 2024-08-15 Pharma& Schweiz Gmbh Treating haematological malignancies by means of satraplatin.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078662A1 (en) * 2002-03-13 2003-09-25 Genomic Health Gene expression profiling in biopsied tumor tissues
WO2007028146A2 (en) * 2005-09-01 2007-03-08 Precision Therapeutics, Inc. Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics
WO2009037337A1 (en) * 2007-09-20 2009-03-26 Novartis Ag Robust and tissue independent gender-specific transcript markers for molecular gender determination
WO2009068621A1 (en) * 2007-11-30 2009-06-04 Glaxosmithkline Biologicals S.A. Method for classifying cancer patients as responder or non-responder to immunotherapy

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394448A (en) 1978-02-24 1983-07-19 Szoka Jr Francis C Method of inserting DNA into living cells
US4769331A (en) 1981-09-16 1988-09-06 University Patents, Inc. Recombinant methods and materials
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5833975A (en) 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
IL84154A0 (en) 1986-10-16 1988-03-31 Microgenesys Inc Polypeptides derived from the envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells and vaccines against acquired immune deficiency syndrome containing the same
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Method and kits for the amplification and detection of nucleic acid sequences
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
JP2846018B2 (en) 1988-01-21 1999-01-13 ジェネンテク，インコーポレイテッド Amplification and detection of nucleic acid sequences
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
WO1990001543A1 (en) 1988-07-29 1990-02-22 Intracel Corporation Method for the genetic expression of heterologous proteins by cells transfected in vivo
CA2003300A1 (en) 1988-11-21 1990-05-21 Franklin Volvovitz Skin test and test kit for aids
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5591439A (en) 1989-03-24 1997-01-07 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
US5552143A (en) 1989-03-24 1996-09-03 The Wistar Institute Of Anatomy & Biology Recombinant cytomegalovirus vaccine
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
GB9001766D0 (en) 1990-01-25 1990-03-28 Univ Court Of The University O Vaccines
US5514375A (en) 1990-08-15 1996-05-07 Virogenetics Corporation Flavivirus recombinant poxvirus vaccine
MY109299A (en) 1990-08-15 1996-12-31 Virogenetics Corp Recombinant pox virus encoding flaviviral structural proteins
US5997878A (en) 1991-03-07 1999-12-07 Connaught Laboratories Recombinant poxvirus-cytomegalovirus, compositions and uses
KR100242671B1 (en) 1991-03-07 2000-03-02 고돈 에릭 Genetically engineered vaccine strain
US5169766A (en) 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
ATE241426T1 (en) 1991-11-22 2003-06-15 Affymetrix Inc A Delaware Corp METHOD FOR PRODUCING POLYMER ARRAYS
US5668648A (en) 1991-11-26 1997-09-16 Kabushiki Kaisha Toshiba Computer-assisted holographic display apparatus
US5846945A (en) 1993-02-16 1998-12-08 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6485729B1 (en) 1993-09-13 2002-11-26 Protein Sciences Corporation Neuraminidase-supplemented compositions
EP0730663B1 (en) 1993-10-26 2003-09-24 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5869255A (en) 1994-02-01 1999-02-09 The Regents Of The University Of California Probes labeled with energy transfer couples dyes exemplified with DNA fragment analysis
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
FR2728795B1 (en) 1994-12-30 1997-03-21 Rhone Merieux AVIAN RECOMBINANT LIVING VACCINE USING AVIAN HERPES VIRUS AS A VECTOR
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
CA2223896A1 (en) 1995-06-08 1996-12-27 Robert Hugh Don Method and apparatus for dna extraction
US5728528A (en) 1995-09-20 1998-03-17 The Regents Of The University Of California Universal spacer/energy transfer dyes
FR2741806B1 (en) 1995-11-30 1998-02-20 Rhone Merieux RECOMBINANT LIVING VACCINE BASED ON TYPE 1 FELINE HERPESVIRUS, PARTICULARLY AGAINST FELIN INFECTIOUS PERITONITIS
WO1997029212A1 (en) 1996-02-08 1997-08-14 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
FR2750866B1 (en) 1996-06-27 1998-11-27 Rhone Merieux AVIAN RECOMBINANT LIVING VACCINE USING AVIAN INFECTIOUS LARYNGOTRACHEITIS VIRUS
FR2750865B1 (en) 1996-06-27 1998-12-04 Rhone Merieux RECOMBINANT LIVING VACCINE BASED ON CANINE HERPESVIRUS, IN PARTICULAR FOR SQUARE DISEASE, RABIES OR TYPE 2 PARAINFLUENZA VIRUS
US6090393A (en) 1996-07-03 2000-07-18 Merial Recombinant canine adenoviruses, method for making and uses thereof
FR2751223B1 (en) 1996-07-19 1998-12-04 Rhone Merieux FELIN POLYNUCLEOTIDE VACCINE FORMULA
FR2751227B1 (en) 1996-07-19 1998-11-27 Rhone Merieux POLYNUCLEOTIDE VACCINE FORMULA AGAINST CANINE CONDITIONS, ESPECIALLY RESPIRATORY AND DIGESTIVE CONDITIONS
FR2751229B1 (en) 1996-07-19 1998-11-27 Rhone Merieux POLYNUCLEOTIDE VACCINE FORMULA IN PARTICULAR AGAINST RESPIRATORY PATHOLOGY OF CATTLE
FR2751225B1 (en) 1996-07-19 1998-11-27 Rhone Merieux AVIAN POLYNUCLEOTIDE VACCINE FORMULA
FR2751228B1 (en) 1996-07-19 1998-11-20 Rhone Merieux BOVINE POLYNUCLEOTIDE VACCINE FOR INTRADERMAL ROUTE
FR2751224B1 (en) 1996-07-19 1998-11-20 Rhone Merieux POLYNUCLEOTIDE VACCINE FORMULA AGAINST BREATHING AND PIG REPRODUCTIVE CONDITIONS
FR2751226B1 (en) 1996-07-19 1998-11-27 Rhone Merieux POLYNUCLEOTIDE VACCINE FORMULA AGAINST HORSE PATHOLOGIES
US5853992A (en) 1996-10-04 1998-12-29 The Regents Of The University Of California Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels
CN1195863C (en) 1996-10-17 2005-04-06 牛津生物医学（英国）有限公司 Retroviral vectors
FR2757061B1 (en) 1996-12-16 1999-03-26 Rhone Merieux AVIAN RECOMBINANT LIVING VACCINE USING AVIAN INFECTIOUS LARYNGOTRACHEITIS VIRUS AS A VECTOR
FR2758986B1 (en) 1997-01-31 1999-04-30 Rhone Merieux AVIAN RECOMBINANT LIVING VACCINE USING AVIAN INFECTIOUS LARYNGOTRACHEITIS VIRUS AS A VECTOR
US6183752B1 (en) 1997-02-05 2001-02-06 Pasteur Merieux Serums Et Vaccins Restenosis/atherosclerosis diagnosis, prophylaxis and therapy
US6368603B1 (en) 1997-03-05 2002-04-09 Merial Limited Lyme combination compositions and uses
US6004777A (en) 1997-03-12 1999-12-21 Virogenetics Corporation Vectors having enhanced expression, and methods of making and uses thereof
US5990091A (en) 1997-03-12 1999-11-23 Virogenetics Corporation Vectors having enhanced expression, and methods of making and uses thereof
US6348450B1 (en) 1997-08-13 2002-02-19 The Uab Research Foundation Noninvasive genetic immunization, expression products therefrom and uses thereof
FR2781159B1 (en) 1998-07-06 2000-10-06 Merial Sas CIRCOVIRUS VACCINE AND PIG PARVOVIRUS
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
US6224882B1 (en) 1997-11-07 2001-05-01 Protein Science Corp. Insect cells or fractions as adjuvant for antigens
PT1895010E (en) 1997-12-22 2012-01-25 Oxford Biomedica Ltd Equine infectious anaemia virus (eiav) based vectors
US6103526A (en) 1998-10-08 2000-08-15 Protein Sciences Corporation Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
EP1130113A1 (en) 2000-02-15 2001-09-05 Johannes Petrus Schouten Multiplex ligation dependent amplification assay
US6548256B2 (en) 2000-07-14 2003-04-15 Eppendorf 5 Prime, Inc. DNA isolation method and kit
EP2491139A1 (en) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
EP2491140A1 (en) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078662A1 (en) * 2002-03-13 2003-09-25 Genomic Health Gene expression profiling in biopsied tumor tissues
WO2007028146A2 (en) * 2005-09-01 2007-03-08 Precision Therapeutics, Inc. Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics
WO2009037337A1 (en) * 2007-09-20 2009-03-26 Novartis Ag Robust and tissue independent gender-specific transcript markers for molecular gender determination
WO2009068621A1 (en) * 2007-11-30 2009-06-04 Glaxosmithkline Biologicals S.A. Method for classifying cancer patients as responder or non-responder to immunotherapy

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CELLULAR ONCOLOGY : THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR CELLULAR ONCOLOGY 2009 LNKD- PUBMED:19096145, vol. 31, no. 1, 2009, pages 1 - 10, ISSN: 1875-8606 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 2009, MOELANS CATHY B ET AL: "HER-2/neu amplification testing in breast cancer by multiplex ligation-dependent probe amplification in comparison with immunohistochemistry and in situ hybridization.", XP002679315, Database accession no. NLM19096145 *
HAI JIANG ET AL: "The combined status of ATM and p53 link tumor development with therapeutic response", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, vol. 23, no. 16, 15 August 2009 (2009-08-15), pages 1895 - 1909, XP002675205, ISSN: 0890-9369, [retrieved on 20090716], DOI: 10.1101/GAD.1815309 *
JAZAERI AMIR A ET AL: "BRCA1-mediated repression of select X chromosome genes", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 2, no. 1, 21 September 2004 (2004-09-21), pages 32, XP021009836, ISSN: 1479-5876, DOI: 10.1186/1479-5876-2-32 *
M. A. VOLLEBERGH ET AL: "An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients", ANNALS OF ONCOLOGY, vol. 22, no. 7, 6 December 2010 (2010-12-06), pages 1561 - 1570, XP055031907, ISSN: 0923-7534, DOI: 10.1093/annonc/mdq624 *
SILKE LASSMANN ET AL: "Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal and microsatellite-unstable sporadic colorectal carcinomas", JOURNAL OF MOLECULAR MEDICINE, SPRINGER, BERLIN, DE, vol. 85, no. 3, 2 December 2006 (2006-12-02), pages 293 - 304, XP019482601, ISSN: 1432-1440 *
SODERLUND ET AL: "Intact Mre11/Rad50/Nbs1 Complex Predicts Good Response to Radiotherapy in Early Breast Cancer", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS, PERGAMON PRESS, USA, vol. 68, no. 1, 19 April 2007 (2007-04-19), pages 50 - 58, XP022099234, ISSN: 0360-3016, DOI: 10.1016/J.IJROBP.2006.12.005 *
SUDBARK R ET AL: "X chromosome-specific cDNA arrays: identification of genes that escape from X-inactivation and other applications", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, vol. 10, no. 1, 1 January 2001 (2001-01-01), pages 77 - 83, XP002904373, ISSN: 0964-6906, DOI: 10.1093/HMG/10.1.77 *
TARON MIQUEL ET AL: "BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, vol. 13, no. 20, 15 October 2004 (2004-10-15), pages 2443 - 2449, XP002500639, ISSN: 0964-6906, DOI: 10.1093/HMG/DDH260 *

Also Published As

Publication number Publication date
WO2012090073A2 (en) 2012-07-05

Similar Documents

Publication Publication Date Title
WO2014160499A3 (en) Methods and compositions for detecting pancreatic cancer
IL238335A0 (en) Prognostic and diagnostic methods for ovarian cancer, and compositions and uses thereof for treating same
MX341734B (en) Biomarkers for predicting the efficacy of an immunotherapy against cancer.
WO2014031859A3 (en) Compositions and methods relating to blood-based biomarkers of breast cancer
WO2012138789A3 (en) Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
WO2012021887A3 (en) Biomarkers for the early detection of breast cancer
IN2014DN08831A (en)
MX2012008490A (en) Targeted genomic alteration.
EP2683643A4 (en) Prostate cancer cell lines, gene signatures and uses thereof
WO2012006447A3 (en) Gene signatures for cancer prognosis
WO2012090073A3 (en) Methods and compositions for predicting chemotherapy sensitivity
WO2014160645A3 (en) Neuroendocrine tumors
WO2012030840A9 (en) Gene signatures for cancer diagnosis and prognosis
HK1200120A1 (en) Antagonists of products of the hs.459642 unigene cluster for the inhibition of proliferation, development or differentiation of stem cells including cancer stem cells hs.459642
WO2012012225A9 (en) Predicting cancer outcome
WO2011106709A3 (en) Epithelial biomarkers for cancer prognosis
WO2011112845A3 (en) Methods and compositions related to a multi-methylation assay to predict patient outcome
EP2601314A4 (en) Prognostic gene signatures for non-small cell lung cancer
WO2013188469A3 (en) Pathways characterization of cells
EP2531619A4 (en) Hypoxia-related gene signatures for cancer classification
EP2945629A4 (en) Chemotherapy for drug-resistant cancer cells
WO2014072832A8 (en) Biomarkers for cervical cancer
EP2606909A4 (en) Method and composition for treating, preventing and diagnosing cancer containing cancer stem cells or derived therefrom
EP2601530A4 (en) Compositions and methods for detecting, diagnosing, and treating cancer
WO2013040358A3 (en) Assays and compositions for detection of agr2

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11826204

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 11826204

Country of ref document: EP

Kind code of ref document: A2