WO2012088247A3 - Fragments et anticorps anti-c5/c5a/c5adesr - Google Patents
Fragments et anticorps anti-c5/c5a/c5adesr Download PDFInfo
- Publication number
- WO2012088247A3 WO2012088247A3 PCT/US2011/066437 US2011066437W WO2012088247A3 WO 2012088247 A3 WO2012088247 A3 WO 2012088247A3 US 2011066437 W US2011066437 W US 2011066437W WO 2012088247 A3 WO2012088247 A3 WO 2012088247A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- c5adesr
- polypeptide
- antibodies
- antigen
- fragments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2822288A CA2822288A1 (fr) | 2010-12-22 | 2011-12-21 | Fragments et anticorps anti-c5/c5a/c5adesr |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061426021P | 2010-12-22 | 2010-12-22 | |
US61/426,021 | 2010-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012088247A2 WO2012088247A2 (fr) | 2012-06-28 |
WO2012088247A3 true WO2012088247A3 (fr) | 2012-09-20 |
Family
ID=46314882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/066437 WO2012088247A2 (fr) | 2010-12-22 | 2011-12-21 | Fragments et anticorps anti-c5/c5a/c5adesr |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2822288A1 (fr) |
WO (1) | WO2012088247A2 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2006381B1 (fr) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Procédé de régulation de la pharmacocinétique sanguine des anticorps |
PL2202245T3 (pl) | 2007-09-26 | 2017-02-28 | Chugai Seiyaku Kabushiki Kaisha | Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr |
ES2563483T3 (es) | 2008-04-11 | 2016-03-15 | Chugai Seiyaku Kabushiki Kaisha | Molécula de unión a antígeno capaz de unirse repetidamente a dos o más moléculas de antígeno |
US20140234340A1 (en) | 2010-11-30 | 2014-08-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
DK2718322T3 (en) | 2011-06-06 | 2018-12-03 | Novo Nordisk As | THERAPEUTIC ANTIBODIES |
WO2015021409A1 (fr) * | 2013-08-09 | 2015-02-12 | King's College London | Compositions et méthodes associées au c5l2 |
BR112016015589A2 (pt) * | 2014-01-06 | 2017-10-31 | Hoffmann La Roche | módulos de trânsito monovalentes para a barreira hematoencefálica |
NZ711451A (en) * | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
KR20230044338A (ko) | 2014-12-19 | 2023-04-03 | 추가이 세이야쿠 가부시키가이샤 | 항-c5 항체 및 그의 사용 방법 |
MX2018003822A (es) | 2015-10-02 | 2018-06-22 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso. |
CA3026050A1 (fr) | 2016-08-05 | 2018-02-08 | Chugai Seiyaku Kabushiki Kaisha | Composition pour la prophylaxie ou le traitement de maladies liees a il-8 |
EP3529619B1 (fr) * | 2016-10-19 | 2021-06-30 | Alexion Pharmaceuticals, Inc. | Procédé de quantification de c5a non lié dans un échantillon |
US11965884B2 (en) * | 2016-10-19 | 2024-04-23 | Alexion Pharmaceuticals, Inc. | Method of quantitating unbound C5 in a sample |
AU2018237300A1 (en) * | 2017-03-23 | 2019-10-17 | The Trustees Of The University Of Pennsylvania | Anti-C5a antibodies and uses thereof |
SG11202002384VA (en) | 2017-10-14 | 2020-04-29 | Cytomx Therapeutics Inc | Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof |
WO2020061560A1 (fr) * | 2018-09-21 | 2020-03-26 | The University Of North Carolina At Chapel Hill | Agents de liaison synthétiques permettant de limiter la perméation à travers le mucus |
JP2023532316A (ja) * | 2020-06-24 | 2023-07-27 | スタイドソン・(ベイジン)・バイオファーマシューティカルズ・カンパニー・リミテッド | C5aを特異的に認識する抗体およびその使用 |
CN114149501B (zh) * | 2020-12-11 | 2023-05-26 | 天士力生物医药股份有限公司 | 抗c5抗体及其应用 |
WO2023116574A1 (fr) * | 2021-12-22 | 2023-06-29 | 舒泰神(北京)生物制药股份有限公司 | Anticorps anti-c5a isolé, sa préparation et son utilisation |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001058956A2 (fr) * | 2000-02-10 | 2001-08-16 | Abbott Laboratories | Anticorps de liaison de l'interleukine 18 humaine et procedes de preparation et d'utilisation |
US20030099647A1 (en) * | 2001-10-05 | 2003-05-29 | Deshpande Rajendra V. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
US20040191260A1 (en) * | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US20060286112A1 (en) * | 2005-05-16 | 2006-12-21 | Sirid-Aimee Kellermann | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
US20090169562A1 (en) * | 2006-06-06 | 2009-07-02 | Mark Throsby | Human Binding Molecules Having Killing Activity Against Enterococci and Uses Thereof |
US20090286283A1 (en) * | 2008-05-16 | 2009-11-19 | Samsung Electronics Co., Ltd. | Method and affinity column for purifying proteins |
US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
US20100034809A1 (en) * | 2008-08-05 | 2010-02-11 | Novartis Ag | Compositions and Methods for Antibodies Targeting Complement Protein C5 |
-
2011
- 2011-12-21 WO PCT/US2011/066437 patent/WO2012088247A2/fr active Application Filing
- 2011-12-21 CA CA2822288A patent/CA2822288A1/fr not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001058956A2 (fr) * | 2000-02-10 | 2001-08-16 | Abbott Laboratories | Anticorps de liaison de l'interleukine 18 humaine et procedes de preparation et d'utilisation |
US20030099647A1 (en) * | 2001-10-05 | 2003-05-29 | Deshpande Rajendra V. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
US20040191260A1 (en) * | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US20060286112A1 (en) * | 2005-05-16 | 2006-12-21 | Sirid-Aimee Kellermann | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
US20090169562A1 (en) * | 2006-06-06 | 2009-07-02 | Mark Throsby | Human Binding Molecules Having Killing Activity Against Enterococci and Uses Thereof |
US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
US20090286283A1 (en) * | 2008-05-16 | 2009-11-19 | Samsung Electronics Co., Ltd. | Method and affinity column for purifying proteins |
US20100034809A1 (en) * | 2008-08-05 | 2010-02-11 | Novartis Ag | Compositions and Methods for Antibodies Targeting Complement Protein C5 |
Non-Patent Citations (4)
Title |
---|
DATABASE UNIPROTKB [online] 4 November 2008 (2008-11-04), retrieved from http://www.uniprot.org/uniprot/B5RTL3 Database accession no. B5RTL3 * |
LARRICK ET AL.: "Characterization of Murine Monoclonal Antibodies That Recognize Neutralizing Epitopes on Human C5a.", INFECT LMMUN., vol. 55, no. 8, 1987, pages 1867 - 1872, XP002570405 * |
MAHAFFEY ET AL.: "Effect of Pexelizumab, an Anti-C5 Complement Antibody, as Adjunctive Therapy to Fibrinolysis in Acute Myocardial Infarction The COMPlement inhibition in myocardial infarction treated with thromboLYtics (COMPLY) Trial.", CIRCULATION., vol. 108, no. 10, 2003, pages 1176 - 1183 * |
RAINARD ET AL.: "Quantification of C5a/C5a(desArg) in bovine plasma, serum and milk.", VET RES., vol. 29, no. 1, 1998, pages 73 - 88 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012088247A2 (fr) | 2012-06-28 |
CA2822288A1 (fr) | 2012-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2012088247A3 (fr) | Fragments et anticorps anti-c5/c5a/c5adesr | |
WO2010136311A3 (fr) | Compositions et procédés de ciblage de la protéine c3b de complément par des anticorps | |
WO2013173761A3 (fr) | Protéines de liaison à l'antigène st2 | |
WO2013011076A3 (fr) | Protéines de liaison à un antigène ayant une liaison accrue à fcrn | |
IN2014MN00873A (fr) | ||
WO2010017103A3 (fr) | Anticorps monoclonaux anti-nkg2d humain entièrement humains | |
WO2013043933A3 (fr) | Protéines de liaison à un antigène cd27l | |
WO2011146514A3 (fr) | Isolement rapide d'anticorps monoclonaux à partir d'animaux | |
MX353931B (es) | Anticuerpos que se unen a ox40 y sus usos. | |
WO2009081285A3 (fr) | Anticorps contre le virus de l'hépatite c | |
WO2011032161A3 (fr) | Vaccins dirigés contre les cellules de langerhans | |
PH12013502205A1 (en) | Antibodies to il-6 and their uses | |
IN2012DN02634A (fr) | ||
EA030777B9 (ru) | Анти-альфа-синуклеинсвязывающие молекулы | |
WO2010043977A3 (fr) | Anticorps de neutralisation du virus de la dengue et leurs utilisations | |
MX2011012039A (es) | Anticuerpos bloqueadores anti-dkk-1 y sus usos. | |
WO2011004028A3 (fr) | Agents de liaison à tlr3 | |
WO2012156532A8 (fr) | Anticorps anti-her3 humain et leurs utilisations | |
WO2011002968A3 (fr) | Polypeptides et procédé de traitement | |
NZ629553A (en) | Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof | |
MX2010001237A (es) | Nuevos anticuerpos. | |
WO2012125733A3 (fr) | Méthodes de dépistage d'anticorps | |
PH12020550825A1 (en) | Anti-c5 antibody combinations and uses thereof | |
WO2010118203A3 (fr) | Molécules de liaison à l'endosialine | |
EP2552961A4 (fr) | Anticorps humanisés de il-25 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11850408 Country of ref document: EP Kind code of ref document: A2 |
|
ENP | Entry into the national phase |
Ref document number: 2822288 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2013546366 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 11850408 Country of ref document: EP Kind code of ref document: A2 |