WO2012088247A3 - Fragments et anticorps anti-c5/c5a/c5adesr - Google Patents

Fragments et anticorps anti-c5/c5a/c5adesr Download PDF

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Publication number
WO2012088247A3
WO2012088247A3 PCT/US2011/066437 US2011066437W WO2012088247A3 WO 2012088247 A3 WO2012088247 A3 WO 2012088247A3 US 2011066437 W US2011066437 W US 2011066437W WO 2012088247 A3 WO2012088247 A3 WO 2012088247A3
Authority
WO
WIPO (PCT)
Prior art keywords
c5adesr
polypeptide
antibodies
antigen
fragments
Prior art date
Application number
PCT/US2011/066437
Other languages
English (en)
Other versions
WO2012088247A2 (fr
Inventor
Caroline COLLEY
Claire Dobson
Joanne BRENNAN
Sek Fung
Original Assignee
Medimmune, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune, Llc filed Critical Medimmune, Llc
Priority to CA2822288A priority Critical patent/CA2822288A1/fr
Publication of WO2012088247A2 publication Critical patent/WO2012088247A2/fr
Publication of WO2012088247A3 publication Critical patent/WO2012088247A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des compositions, des procédés de fabrication et des procédés d'utilisation se rapportant à des anticorps anti-C5/C5a/C5adesR et à des fragments de liaison à l'antigène.
PCT/US2011/066437 2010-12-22 2011-12-21 Fragments et anticorps anti-c5/c5a/c5adesr WO2012088247A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2822288A CA2822288A1 (fr) 2010-12-22 2011-12-21 Fragments et anticorps anti-c5/c5a/c5adesr

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061426021P 2010-12-22 2010-12-22
US61/426,021 2010-12-22

Publications (2)

Publication Number Publication Date
WO2012088247A2 WO2012088247A2 (fr) 2012-06-28
WO2012088247A3 true WO2012088247A3 (fr) 2012-09-20

Family

ID=46314882

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/066437 WO2012088247A2 (fr) 2010-12-22 2011-12-21 Fragments et anticorps anti-c5/c5a/c5adesr

Country Status (2)

Country Link
CA (1) CA2822288A1 (fr)
WO (1) WO2012088247A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2006381B1 (fr) 2006-03-31 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Procédé de régulation de la pharmacocinétique sanguine des anticorps
PL2202245T3 (pl) 2007-09-26 2017-02-28 Chugai Seiyaku Kabushiki Kaisha Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr
ES2563483T3 (es) 2008-04-11 2016-03-15 Chugai Seiyaku Kabushiki Kaisha Molécula de unión a antígeno capaz de unirse repetidamente a dos o más moléculas de antígeno
US20140234340A1 (en) 2010-11-30 2014-08-21 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
DK2718322T3 (en) 2011-06-06 2018-12-03 Novo Nordisk As THERAPEUTIC ANTIBODIES
WO2015021409A1 (fr) * 2013-08-09 2015-02-12 King's College London Compositions et méthodes associées au c5l2
BR112016015589A2 (pt) * 2014-01-06 2017-10-31 Hoffmann La Roche módulos de trânsito monovalentes para a barreira hematoencefálica
NZ711451A (en) * 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
KR20230044338A (ko) 2014-12-19 2023-04-03 추가이 세이야쿠 가부시키가이샤 항-c5 항체 및 그의 사용 방법
MX2018003822A (es) 2015-10-02 2018-06-22 Hoffmann La Roche Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso.
CA3026050A1 (fr) 2016-08-05 2018-02-08 Chugai Seiyaku Kabushiki Kaisha Composition pour la prophylaxie ou le traitement de maladies liees a il-8
EP3529619B1 (fr) * 2016-10-19 2021-06-30 Alexion Pharmaceuticals, Inc. Procédé de quantification de c5a non lié dans un échantillon
US11965884B2 (en) * 2016-10-19 2024-04-23 Alexion Pharmaceuticals, Inc. Method of quantitating unbound C5 in a sample
AU2018237300A1 (en) * 2017-03-23 2019-10-17 The Trustees Of The University Of Pennsylvania Anti-C5a antibodies and uses thereof
SG11202002384VA (en) 2017-10-14 2020-04-29 Cytomx Therapeutics Inc Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof
WO2020061560A1 (fr) * 2018-09-21 2020-03-26 The University Of North Carolina At Chapel Hill Agents de liaison synthétiques permettant de limiter la perméation à travers le mucus
JP2023532316A (ja) * 2020-06-24 2023-07-27 スタイドソン・（ベイジン）・バイオファーマシューティカルズ・カンパニー・リミテッド Ｃ５ａを特異的に認識する抗体およびその使用
CN114149501B (zh) * 2020-12-11 2023-05-26 天士力生物医药股份有限公司 抗c5抗体及其应用
WO2023116574A1 (fr) * 2021-12-22 2023-06-29 舒泰神（北京）生物制药股份有限公司 Anticorps anti-c5a isolé, sa préparation et son utilisation

Citations (8)

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WO2001058956A2 (fr) * 2000-02-10 2001-08-16 Abbott Laboratories Anticorps de liaison de l'interleukine 18 humaine et procedes de preparation et d'utilisation
US20030099647A1 (en) * 2001-10-05 2003-05-29 Deshpande Rajendra V. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
US20040191260A1 (en) * 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US20060286112A1 (en) * 2005-05-16 2006-12-21 Sirid-Aimee Kellermann Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
US20090169562A1 (en) * 2006-06-06 2009-07-02 Mark Throsby Human Binding Molecules Having Killing Activity Against Enterococci and Uses Thereof
US20090286283A1 (en) * 2008-05-16 2009-11-19 Samsung Electronics Co., Ltd. Method and affinity column for purifying proteins
US20090304590A1 (en) * 2007-05-29 2009-12-10 Wyeth Therapeutic compositions and methods
US20100034809A1 (en) * 2008-08-05 2010-02-11 Novartis Ag Compositions and Methods for Antibodies Targeting Complement Protein C5

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001058956A2 (fr) * 2000-02-10 2001-08-16 Abbott Laboratories Anticorps de liaison de l'interleukine 18 humaine et procedes de preparation et d'utilisation
US20030099647A1 (en) * 2001-10-05 2003-05-29 Deshpande Rajendra V. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
US20040191260A1 (en) * 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US20060286112A1 (en) * 2005-05-16 2006-12-21 Sirid-Aimee Kellermann Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
US20090169562A1 (en) * 2006-06-06 2009-07-02 Mark Throsby Human Binding Molecules Having Killing Activity Against Enterococci and Uses Thereof
US20090304590A1 (en) * 2007-05-29 2009-12-10 Wyeth Therapeutic compositions and methods
US20090286283A1 (en) * 2008-05-16 2009-11-19 Samsung Electronics Co., Ltd. Method and affinity column for purifying proteins
US20100034809A1 (en) * 2008-08-05 2010-02-11 Novartis Ag Compositions and Methods for Antibodies Targeting Complement Protein C5

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE UNIPROTKB [online] 4 November 2008 (2008-11-04), retrieved from http://www.uniprot.org/uniprot/B5RTL3 Database accession no. B5RTL3 *
LARRICK ET AL.: "Characterization of Murine Monoclonal Antibodies That Recognize Neutralizing Epitopes on Human C5a.", INFECT LMMUN., vol. 55, no. 8, 1987, pages 1867 - 1872, XP002570405 *
MAHAFFEY ET AL.: "Effect of Pexelizumab, an Anti-C5 Complement Antibody, as Adjunctive Therapy to Fibrinolysis in Acute Myocardial Infarction The COMPlement inhibition in myocardial infarction treated with thromboLYtics (COMPLY) Trial.", CIRCULATION., vol. 108, no. 10, 2003, pages 1176 - 1183 *
RAINARD ET AL.: "Quantification of C5a/C5a(desArg) in bovine plasma, serum and milk.", VET RES., vol. 29, no. 1, 1998, pages 73 - 88 *

Also Published As

Publication number Publication date
WO2012088247A2 (fr) 2012-06-28
CA2822288A1 (fr) 2012-06-28

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