WO2012070962A3 - Process and apparatus for freezing in plates to obtain ice matrixes with a uniform distribution of solutes - Google Patents

Process and apparatus for freezing in plates to obtain ice matrixes with a uniform distribution of solutes Download PDF

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Publication number
WO2012070962A3
WO2012070962A3 PCT/PT2011/000040 PT2011000040W WO2012070962A3 WO 2012070962 A3 WO2012070962 A3 WO 2012070962A3 PT 2011000040 W PT2011000040 W PT 2011000040W WO 2012070962 A3 WO2012070962 A3 WO 2012070962A3
Authority
WO
WIPO (PCT)
Prior art keywords
freezing
solutes
matrixes
plates
uniform distribution
Prior art date
Application number
PCT/PT2011/000040
Other languages
French (fr)
Other versions
WO2012070962A2 (en
Inventor
Miguel Ângelo Joaquim RODRIGUES
Gustavo Bruzual Balzan
Vitor Manuel Geraldes Fernandez
Henrique aníba Santos de MATOS
Edmundo José Simões Gomes de AZEVEDO
Original Assignee
Instituto Superiior Técnico
Universidade Do Algarve
Universidade De Lisboa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto Superiior Técnico, Universidade Do Algarve, Universidade De Lisboa filed Critical Instituto Superiior Técnico
Publication of WO2012070962A2 publication Critical patent/WO2012070962A2/en
Publication of WO2012070962A3 publication Critical patent/WO2012070962A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/36—Freezing; Subsequent thawing; Cooling
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/36—Freezing; Subsequent thawing; Cooling
    • A23L3/363—Freezing; Subsequent thawing; Cooling the materials not being transported through or in the apparatus with or without shaping, e.g. in form of powder, granules, or flakes
    • A23L3/364—Freezing; Subsequent thawing; Cooling the materials not being transported through or in the apparatus with or without shaping, e.g. in form of powder, granules, or flakes with packages or with shaping in form of blocks or portions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/36—Freezing; Subsequent thawing; Cooling
    • A23L3/37—Freezing; Subsequent thawing; Cooling with addition of or treatment with chemicals
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D11/00—Self-contained movable devices, e.g. domestic refrigerators
    • F25D11/04—Self-contained movable devices, e.g. domestic refrigerators specially adapted for storing deep-frozen articles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D31/00—Other cooling or freezing apparatus
    • F25D31/001—Plate freezers

Abstract

This invention is a controlled freezing process and an apparatus that aims to attenuate the effect of cryoconcentration of solutes that occurs during the freezing of aqueous solutions, by means of a freezing method that gives the user an adequate control of the speed and of the direction of the interface between the solid and the liquid phases in order to incorporate the solutes uniformly in the ice matrix. This invention has applications in the pharmaceutical industry, the food industry and also in the industry for development and commercialization of cryogenic technology.
PCT/PT2011/000040 2010-11-26 2011-11-25 Process and apparatus for freezing in plates to obtain ice matrixes with a uniform distribution of solutes WO2012070962A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT10540510A PT105405B (en) 2010-11-26 2010-11-26 PROCESS AND FREEZER APPLICATION IN DISHES FOR OBTAINING ICE MATRIXES WITH DISTRIBUTION OF UNIFORM SOLUTIONS
PT105405 2010-11-26

Publications (2)

Publication Number Publication Date
WO2012070962A2 WO2012070962A2 (en) 2012-05-31
WO2012070962A3 true WO2012070962A3 (en) 2012-08-02

Family

ID=45406824

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PT2011/000040 WO2012070962A2 (en) 2010-11-26 2011-11-25 Process and apparatus for freezing in plates to obtain ice matrixes with a uniform distribution of solutes

Country Status (2)

Country Link
PT (1) PT105405B (en)
WO (1) WO2012070962A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115176118A (en) * 2019-12-16 2022-10-11 西北大学 Lyophilized reagents

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03188903A (en) * 1989-12-20 1991-08-16 Toyo Eng Works Ltd Pressurized freeze concentrator
WO2000072902A1 (en) * 1999-05-28 2000-12-07 Integrated Biosystems Enhanced thawing of biopharmaceutical solutions using oscillatory motion
US20020177119A1 (en) * 2001-05-22 2002-11-28 Richard Wisniewski Cryopreservation system with controlled dendritic freezing front velocity
WO2003037083A1 (en) * 2001-11-01 2003-05-08 Integrated Biosystems, Inc. Systems and methods for freezing and storing biopharmacuetical material
EP1407202A1 (en) * 2001-07-13 2004-04-14 Integrated Biosystems Inc. Cryopreservation system with controlled dendritic freezing front velocity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438634A (en) 1982-11-05 1984-03-27 General Mills, Inc. Freeze concentration apparatus
US4947546A (en) 1989-03-28 1990-08-14 Amp Incorporated Method of making a cable assembly
US6855354B2 (en) 2001-02-13 2005-02-15 Morinda, Inc. Freeze concentration process

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03188903A (en) * 1989-12-20 1991-08-16 Toyo Eng Works Ltd Pressurized freeze concentrator
WO2000072902A1 (en) * 1999-05-28 2000-12-07 Integrated Biosystems Enhanced thawing of biopharmaceutical solutions using oscillatory motion
US20020177119A1 (en) * 2001-05-22 2002-11-28 Richard Wisniewski Cryopreservation system with controlled dendritic freezing front velocity
EP1407202A1 (en) * 2001-07-13 2004-04-14 Integrated Biosystems Inc. Cryopreservation system with controlled dendritic freezing front velocity
WO2003037083A1 (en) * 2001-11-01 2003-05-08 Integrated Biosystems, Inc. Systems and methods for freezing and storing biopharmacuetical material

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHATNAGAR B., S. ET AL: "Post-Thaw Aging Affects Activity of Lactate Dehydrogenase", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 94, no. 6, June 2005 (2005-06-01), XP002675121 *
BUTLER, M., F.: "Growth of Solutal Ice Dendrites Studied by Optical Inferferometry", CRYSTAL GROWTH AND DESIGN, vol. 2, no. 1, 12 December 2001 (2001-12-12), pages 59 - 66, XP002675118 *
DATABASE WPI Week 199139, Derwent World Patents Index; AN 1991-285196, XP002675119 *
RODRIGUES M. A. ET AL: "Effect of Freezing Rate and Dendritic Ice Formation on Concentration Profiles of Proteins Frozen in Cylindrical Vessels", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 4, 9 December 2010 (2010-12-09), pages 1316 - 1329, XP002675120 *

Also Published As

Publication number Publication date
WO2012070962A2 (en) 2012-05-31
PT105405B (en) 2014-08-21
PT105405A (en) 2012-05-28

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