WO2012046145A3 - Coriolus versicolor extracts, methods of preparation and uses thereof - Google Patents

Coriolus versicolor extracts, methods of preparation and uses thereof Download PDF

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Publication number
WO2012046145A3
WO2012046145A3 PCT/IB2011/002845 IB2011002845W WO2012046145A3 WO 2012046145 A3 WO2012046145 A3 WO 2012046145A3 IB 2011002845 W IB2011002845 W IB 2011002845W WO 2012046145 A3 WO2012046145 A3 WO 2012046145A3
Authority
WO
WIPO (PCT)
Prior art keywords
coriolus versicolor
preparation
subject invention
methods
carcinoma
Prior art date
Application number
PCT/IB2011/002845
Other languages
French (fr)
Other versions
WO2012046145A2 (en
Inventor
Allan Sik-Yin Lau
Stanley Chi Chung Chik
Anna Hing-Yee Law
Cindy Lai Hung Yang
Original Assignee
Purapharm International (Hk) Limited
Versitech Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purapharm International (Hk) Limited, Versitech Limited filed Critical Purapharm International (Hk) Limited
Priority to JP2013532289A priority Critical patent/JP5959523B2/en
Priority to US13/876,070 priority patent/US10226493B2/en
Priority to AU2011311251A priority patent/AU2011311251B2/en
Priority to EP11830265.2A priority patent/EP2627341B1/en
Priority to CA2812886A priority patent/CA2812886C/en
Priority to CN201180058847XA priority patent/CN103298476A/en
Publication of WO2012046145A2 publication Critical patent/WO2012046145A2/en
Publication of WO2012046145A3 publication Critical patent/WO2012046145A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The subject invention provides Coriolus versicolor extracts, pharmaceutical compositions comprising the Coriolus versicolor extracts, methods of preparation, and therapeutic uses thereof. Advantageously, the subject Coriolus versicolor extract has immunomodulatory, anti-tumor, anti-microbial, and antiviral effects. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells. In certain preferred embodiments, the subject invention can be used to treat glioblastoma multiforme, nasopharyngeal carcinoma, breast carcinoma, lung carcinoma, prostate cancer, and colon carcinoma, as well as bacterial, viral, fungal, protozoan, and/or other microbial infection.
PCT/IB2011/002845 2010-10-06 2011-10-06 Coriolus versicolor extracts, methods of preparation and uses thereof WO2012046145A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2013532289A JP5959523B2 (en) 2010-10-06 2011-10-06 Kawaratake extract, its preparation method and use
US13/876,070 US10226493B2 (en) 2010-10-06 2011-10-06 Coriolus versicolor extracts, methods of preparation and uses thereof
AU2011311251A AU2011311251B2 (en) 2010-10-06 2011-10-06 Coriolus versicolor extracts, methods of preparation and uses thereof
EP11830265.2A EP2627341B1 (en) 2010-10-06 2011-10-06 Coriolus versicolor extracts, methods of preparation and uses thereof
CA2812886A CA2812886C (en) 2010-10-06 2011-10-06 Coriolus versicolor extracts, methods of preparation and uses thereof
CN201180058847XA CN103298476A (en) 2010-10-06 2011-10-06 Coriolus versicolor extracts, methods of preparation and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39027910P 2010-10-06 2010-10-06
US61/390,279 2010-10-06
US201161432853P 2011-01-14 2011-01-14
US61/432,853 2011-01-14

Publications (2)

Publication Number Publication Date
WO2012046145A2 WO2012046145A2 (en) 2012-04-12
WO2012046145A3 true WO2012046145A3 (en) 2012-06-07

Family

ID=45928165

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/002845 WO2012046145A2 (en) 2010-10-06 2011-10-06 Coriolus versicolor extracts, methods of preparation and uses thereof

Country Status (7)

Country Link
US (1) US10226493B2 (en)
EP (1) EP2627341B1 (en)
JP (2) JP5959523B2 (en)
CN (2) CN107823228B (en)
AU (1) AU2011311251B2 (en)
CA (1) CA2812886C (en)
WO (1) WO2012046145A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3116519T3 (en) 2014-03-13 2019-08-05 Procare Health Iberia S L TOPICAL COMPOSITIONS COMPREHENSIVE EXTRACT FROM CORIOLUS VERSICOLOR TO AUTO IMMUNITY IMPROVEMENT
CN106797958A (en) * 2017-01-05 2017-06-06 泰安市泰山林业科学研究院 A kind of macro fungi preparation of Antiphytoviral and preparation method thereof
JP2019143037A (en) * 2018-02-20 2019-08-29 株式会社メイクリーン Japanese cypress distilled water
CN110713525B (en) * 2019-11-04 2022-09-16 南开大学 Antitumor protein extract in boletus edulis, and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229570A (en) * 1976-07-07 1980-10-21 Kureha Kagaku Kogyo Kabushiki Kaisha Method of producing nitrogen-containing polysaccharides
CN101365338A (en) * 2005-11-08 2009-02-11 维特健灵健康产品有限公司 Herbal powder extracts and methods of preparing and using the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS536412A (en) 1976-07-07 1978-01-20 Kureha Chem Ind Co Ltd Preparation of n-containing polysaccharides
US4851395A (en) 1976-07-07 1989-07-25 Kureha Kagaku Kogyo Kabushiki Kausha Nitrogen-containing polysaccharide
JPH0825896B2 (en) * 1987-06-18 1996-03-13 呉羽化学工業株式会社 Antiretroviral agent
AU3230393A (en) 1992-11-30 1994-06-22 Department Of The Army Purified coriolus versicolor polypeptide complex
US5374714A (en) 1992-11-30 1994-12-20 Yang; Mable M. P. Purified coriolus versicolor polypeptide complex
US6544564B1 (en) * 2001-11-27 2003-04-08 Michael Donald Farley Cytotoxic pharmaceutical composition
KR100971599B1 (en) * 2002-05-15 2010-07-20 비에이취엔 가부시끼가이샤 Composition for Preventing or Treating Blood Vessel-Related Disease
US7048932B2 (en) * 2002-05-22 2006-05-23 The Chinese University Of Hong Kong Preparation and standardization of immunomodulatory peptide-linked glucans with verifiable oral absorbability from coriolus versicolor
CN100471869C (en) * 2002-05-22 2009-03-25 香港中文大学 Preparation and assaying of peptide dextran possessing detectable oral absorption immune regulation of rainbow conk
US20090053221A1 (en) * 2006-01-17 2009-02-26 Cheung Nai-Kong V Immune response enhancing glucan
KR100864455B1 (en) 2006-12-20 2008-10-20 이정식 A Composition comprising the extract of complex herb improving Liver Cirrhosis, cytotoxicity and liver injury for preventing and treating of liver disease
WO2008075888A1 (en) * 2006-12-20 2008-06-26 Jung Sik Lee A composition comprising the extract of combined herbs for preventing and treating liver disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229570A (en) * 1976-07-07 1980-10-21 Kureha Kagaku Kogyo Kabushiki Kaisha Method of producing nitrogen-containing polysaccharides
CN101365338A (en) * 2005-11-08 2009-02-11 维特健灵健康产品有限公司 Herbal powder extracts and methods of preparing and using the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP2627341A4 *
ZHENG JIONG ET AL.: "Research advances in bioactivities and extraction, purification of coriolus versicolor polysaccharides.", CEREALS & OILS, no. 2, 2007, pages 44 - 46, XP008168152 *

Also Published As

Publication number Publication date
WO2012046145A2 (en) 2012-04-12
CA2812886C (en) 2020-04-14
JP2016121167A (en) 2016-07-07
CN103298476A (en) 2013-09-11
CA2812886A1 (en) 2012-04-12
CN107823228B (en) 2021-07-20
AU2011311251B2 (en) 2015-11-26
JP5959523B2 (en) 2016-08-02
JP6185093B2 (en) 2017-08-23
US20140017275A1 (en) 2014-01-16
AU2011311251A1 (en) 2013-05-02
JP2013538869A (en) 2013-10-17
US10226493B2 (en) 2019-03-12
EP2627341A4 (en) 2014-04-02
CN107823228A (en) 2018-03-23
EP2627341A2 (en) 2013-08-21
EP2627341B1 (en) 2018-11-21

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