WO2012042536A3 - A process for preparation of ether derivatives of dihdroartemisinin - Google Patents

A process for preparation of ether derivatives of dihdroartemisinin Download PDF

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Publication number
WO2012042536A3
WO2012042536A3 PCT/IN2011/000659 IN2011000659W WO2012042536A3 WO 2012042536 A3 WO2012042536 A3 WO 2012042536A3 IN 2011000659 W IN2011000659 W IN 2011000659W WO 2012042536 A3 WO2012042536 A3 WO 2012042536A3
Authority
WO
WIPO (PCT)
Prior art keywords
ether derivatives
preparation
dihydroartemisinin
dihdroartemisinin
ether
Prior art date
Application number
PCT/IN2011/000659
Other languages
French (fr)
Other versions
WO2012042536A2 (en
Inventor
Sathya Prasanna
Pejakala Kakrannaya Vasudeva
Thangavel Arulmoli
Koodli Venkatramana Udupa
Original Assignee
Sequent Scientific Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequent Scientific Limited filed Critical Sequent Scientific Limited
Publication of WO2012042536A2 publication Critical patent/WO2012042536A2/en
Publication of WO2012042536A3 publication Critical patent/WO2012042536A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a facile and cost-effective process for the preparation of ether derivatives of dihydroartemisinin. The present invention further enables preparation of pure β-ether derivatives of dihydroartemisinin, commonly known as Artemether, the methyl ether derivative and Arteether, the ethyl ether derivative, which are well-known antimalarial agents without using an organic pro-acid. This invention also discloses a novel epimerisation process for the a-ether derivatives of dihydroartemisinin in β- isomer.
PCT/IN2011/000659 2010-09-27 2011-09-22 A process for preparation of ether derivatives of dihdroartemisinin WO2012042536A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2823CH2010 2010-09-27
IN2823/CHE/2010 2010-09-27

Publications (2)

Publication Number Publication Date
WO2012042536A2 WO2012042536A2 (en) 2012-04-05
WO2012042536A3 true WO2012042536A3 (en) 2012-05-31

Family

ID=45893594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000659 WO2012042536A2 (en) 2010-09-27 2011-09-22 A process for preparation of ether derivatives of dihdroartemisinin

Country Status (1)

Country Link
WO (1) WO2012042536A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104725395B (en) * 2013-12-20 2018-04-10 上海迪赛诺化学制药有限公司 A kind of technique for preparing β Artemethers
CN110903298A (en) * 2019-08-15 2020-03-24 恩施硒禾生物科技有限公司 Preparation method of dihydroartemisinin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008087666A1 (en) * 2007-01-19 2008-07-24 Almet Corporation Preparative process for ether derivative of artemisinin
WO2009109989A1 (en) * 2008-01-21 2009-09-11 Calyx Chemicals And Pharmaceuticals Ltd. A novel process for the preparation of ethers of dihydroartemisinin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008087666A1 (en) * 2007-01-19 2008-07-24 Almet Corporation Preparative process for ether derivative of artemisinin
WO2009109989A1 (en) * 2008-01-21 2009-09-11 Calyx Chemicals And Pharmaceuticals Ltd. A novel process for the preparation of ethers of dihydroartemisinin

Also Published As

Publication number Publication date
WO2012042536A2 (en) 2012-04-05

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