WO2012042536A3 - A process for preparation of ether derivatives of dihdroartemisinin - Google Patents
A process for preparation of ether derivatives of dihdroartemisinin Download PDFInfo
- Publication number
- WO2012042536A3 WO2012042536A3 PCT/IN2011/000659 IN2011000659W WO2012042536A3 WO 2012042536 A3 WO2012042536 A3 WO 2012042536A3 IN 2011000659 W IN2011000659 W IN 2011000659W WO 2012042536 A3 WO2012042536 A3 WO 2012042536A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ether derivatives
- preparation
- dihydroartemisinin
- dihdroartemisinin
- ether
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a facile and cost-effective process for the preparation of ether derivatives of dihydroartemisinin. The present invention further enables preparation of pure β-ether derivatives of dihydroartemisinin, commonly known as Artemether, the methyl ether derivative and Arteether, the ethyl ether derivative, which are well-known antimalarial agents without using an organic pro-acid. This invention also discloses a novel epimerisation process for the a-ether derivatives of dihydroartemisinin in β- isomer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2823/CHE/2010 | 2010-09-27 | ||
IN2823CH2010 | 2010-09-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012042536A2 WO2012042536A2 (en) | 2012-04-05 |
WO2012042536A3 true WO2012042536A3 (en) | 2012-05-31 |
Family
ID=45893594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2011/000659 WO2012042536A2 (en) | 2010-09-27 | 2011-09-22 | A process for preparation of ether derivatives of dihdroartemisinin |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012042536A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104725395B (en) * | 2013-12-20 | 2018-04-10 | 上海迪赛诺化学制药有限公司 | A kind of technique for preparing β Artemethers |
CN110903298A (en) * | 2019-08-15 | 2020-03-24 | 恩施硒禾生物科技有限公司 | Preparation method of dihydroartemisinin |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008087666A1 (en) * | 2007-01-19 | 2008-07-24 | Almet Corporation | Preparative process for ether derivative of artemisinin |
WO2009109989A1 (en) * | 2008-01-21 | 2009-09-11 | Calyx Chemicals And Pharmaceuticals Ltd. | A novel process for the preparation of ethers of dihydroartemisinin |
-
2011
- 2011-09-22 WO PCT/IN2011/000659 patent/WO2012042536A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008087666A1 (en) * | 2007-01-19 | 2008-07-24 | Almet Corporation | Preparative process for ether derivative of artemisinin |
WO2009109989A1 (en) * | 2008-01-21 | 2009-09-11 | Calyx Chemicals And Pharmaceuticals Ltd. | A novel process for the preparation of ethers of dihydroartemisinin |
Also Published As
Publication number | Publication date |
---|---|
WO2012042536A2 (en) | 2012-04-05 |
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