WO2012042091A3 - Uso de inhibidores de tak1 en la prevención y tratamiento del fracaso de la membrana peritoneal - Google Patents
Uso de inhibidores de tak1 en la prevención y tratamiento del fracaso de la membrana peritoneal Download PDFInfo
- Publication number
- WO2012042091A3 WO2012042091A3 PCT/ES2011/070683 ES2011070683W WO2012042091A3 WO 2012042091 A3 WO2012042091 A3 WO 2012042091A3 ES 2011070683 W ES2011070683 W ES 2011070683W WO 2012042091 A3 WO2012042091 A3 WO 2012042091A3
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- WO
- WIPO (PCT)
- Prior art keywords
- peritoneal
- tak1
- treatment
- prevention
- relates
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere al uso de inhibidores de TAK1 para la preparación de un medicamento para la prevención y tratamiento del fracaso de la membrana peritoneal. Donde dicho uso previene y revierte la transición epitelio mesénquima que sufren las células mesoteliales del peritoneo durante el tratamiento de diálisis peritoneal. También, al uso de un producto de expresión de TAK1 o de su actividad como biomarcador para la determinación de fibrosis peritoneal. Al método de obtención de datos útiles en el diagnóstico y/o pronóstico de la fibrosis peritoneal; un método para predecir la progresión de la fibrosis peritoneal. Así como el uso de un kit que comprende la secuencia que codifica para TAK1 o la proteína para el diagnóstico de la fibrosis peritoneal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP201031439 | 2010-09-28 | ||
| ES201031439 | 2010-09-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2012042091A2 WO2012042091A2 (es) | 2012-04-05 |
| WO2012042091A3 true WO2012042091A3 (es) | 2012-07-12 |
Family
ID=45893578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/ES2011/070683 WO2012042091A2 (es) | 2010-09-28 | 2011-09-28 | Uso de inhibidores de tak1 en la prevención y tratamiento del fracaso de la membrana peritoneal |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2012042091A2 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015115158B4 (de) | 2015-09-09 | 2017-07-13 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Kit zur Diagnose von epithelial-mesenchymaler Transition (EMT) des Peritoneums |
-
2011
- 2011-09-28 WO PCT/ES2011/070683 patent/WO2012042091A2/es active Application Filing
Non-Patent Citations (2)
| Title |
|---|
| ONO K. ET AL.: "A dominant negative TAKI inhibits cellular fibrotic responses induced by TGF-beta", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 307, 26 June 2003 (2003-06-26), pages 332 - 337, XP004435306, DOI: doi:10.1016/S0006-291X(03)01207-5 * |
| YAO J. ET AL.: "Interleukin-1 (IL-I)-induced TAKI-dependet versus MEKK3- dependent NFkB activation pathways bifurcate at IL-1 receptor-associated kinase modification", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 9, 29 December 2006 (2006-12-29), pages 6075 - 6089 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012042091A2 (es) | 2012-04-05 |
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