WO2012035549A3 - Procédé amélioré pour la synthèse de dérivés d'acides bêta-aminés - Google Patents
Procédé amélioré pour la synthèse de dérivés d'acides bêta-aminés Download PDFInfo
- Publication number
- WO2012035549A3 WO2012035549A3 PCT/IN2011/000621 IN2011000621W WO2012035549A3 WO 2012035549 A3 WO2012035549 A3 WO 2012035549A3 IN 2011000621 W IN2011000621 W IN 2011000621W WO 2012035549 A3 WO2012035549 A3 WO 2012035549A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- synthesis
- amino acid
- acid derivatives
- improved process
- beta amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention concerne un procédé amélioré ainsi qu'un/des intermédiaire(s) pour la synthèse de dérivés d'acides bêta-aminés représentés par la formule (I). Les composés représentés par la formule (I) servent d'inhibiteurs DPP-IV et sont utiles dans le traitement du diabète de type 2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2164/DEL/2010 | 2010-09-13 | ||
IN2164DE2010 IN2010DE02164A (fr) | 2010-09-13 | 2011-09-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012035549A2 WO2012035549A2 (fr) | 2012-03-22 |
WO2012035549A3 true WO2012035549A3 (fr) | 2012-10-11 |
Family
ID=44898127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2011/000621 WO2012035549A2 (fr) | 2010-09-13 | 2011-09-12 | Procédé amélioré pour la synthèse de dérivés d'acides bêta-aminés |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR082971A1 (fr) |
IN (1) | IN2010DE02164A (fr) |
WO (1) | WO2012035549A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015145333A1 (fr) | 2014-03-26 | 2015-10-01 | Sun Pharmaceutical Industries Limited | Procédé de préparation de sitagliptine et son intermédiaire |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004058266A1 (fr) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | Derives de 3-amino-4-phenylbutanoique acide utilises en tant qu'inhibiteurs de dipeptidyl peptidase pour le traitement ou la prevention du diabete |
WO2006104997A2 (fr) * | 2005-03-29 | 2006-10-05 | Merck & Co., Inc. | Sels d'acide tartarique d'un inhibiteur de la dipeptidyl peptidase iv |
WO2009093269A1 (fr) * | 2008-01-24 | 2009-07-30 | Panacea Biotec Limited | Nouveaux composés hétérocycliques |
WO2010097420A1 (fr) * | 2009-02-25 | 2010-09-02 | Esteve Química, S.A. | Procédé de préparation d'un dérivé béta aminoacide chiral et intermédiaires utilisés dans ledit procédé |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
AU2003251869A1 (en) | 2002-07-15 | 2004-02-02 | Merck & Co., Inc. | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes |
MXPA05004063A (es) | 2002-10-18 | 2005-06-08 | Merck & Co Inc | Inhibidores de la beta-amino heterociclico dipeptidil peptidasa para el tratamiento o prevencion de diabetes. |
AU2003290577B2 (en) | 2002-11-07 | 2008-12-11 | Merck Sharp & Dohme Corp. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
AR043515A1 (es) | 2003-03-19 | 2005-08-03 | Merck & Co Inc | Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica |
DE602004018503D1 (de) | 2003-07-31 | 2009-01-29 | Merck & Co Inc | Hexahydrodiazepinone als inhibitoren des dipeptidylpeptidase-iv zur behandlung bzw. prävention von diabetes |
GB0324236D0 (en) | 2003-10-16 | 2003-11-19 | Astrazeneca Ab | Chemical compounds |
JP2007510651A (ja) | 2003-11-04 | 2007-04-26 | メルク エンド カムパニー インコーポレーテッド | 糖尿病の治療又は予防のためのジペプチジルペプチダーゼ−iv阻害剤としての縮合フェニルアラニン誘導体 |
US7671073B2 (en) | 2004-05-18 | 2010-03-02 | Merck Sharp & Dohme Corp. | Cyclohexylalanine derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
EP1598341A1 (fr) | 2004-05-21 | 2005-11-23 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | Inhibiteurs de DPP-IV |
EP1604989A1 (fr) | 2004-06-08 | 2005-12-14 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | Inhibiteurs de DPP-IV |
EP1604662A1 (fr) | 2004-06-08 | 2005-12-14 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | Derivés de la benzyl amine du acide carboxylique (2R) de la 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine et composés similaires pour l'utilisation comme inhibiteurs de la peptidase dipeptidyl IV (DPP-IV) pour le traitement de la diabetes mellitus de type 2 |
GB0413389D0 (en) | 2004-06-16 | 2004-07-21 | Astrazeneca Ab | Chemical compounds |
WO2006009886A1 (fr) | 2004-06-21 | 2006-01-26 | Merck & Co., Inc. | Aminocyclohexanes en tant qu'inhibiteurs de dipeptidyl peptidase-iv pour le traitement ou la prévention de diabètes |
CA2576465A1 (fr) | 2004-08-23 | 2006-03-02 | Merck & Co., Inc. | Derives de triazole accoles inhibiteurs de la dipeptidyl peptidase-iv utilises dans le traitement ou la prevention du diabete |
ATE481969T1 (de) | 2004-10-01 | 2010-10-15 | Merck Sharp & Dohme | Aminopiperidine als dipeptidylpeptidase-iv- inhibitoren zur behandlung oder prävention von diabetes |
AR052879A1 (es) | 2005-01-24 | 2007-04-11 | Merck & Co Inc | Procedimiento para preparar derivados de beta aminoacidos quirales por hidrogenacion asimetrica |
EP1702916A1 (fr) | 2005-03-18 | 2006-09-20 | Santhera Pharmaceuticals (Schweiz) GmbH | Inhibiteurs de DPP-IV |
EP1943215A2 (fr) | 2005-10-31 | 2008-07-16 | Brystol-Myers Squibb Company | Inhibiteurs à base d amide et de bêta-amino de pyrrolidinyle de la dipeptidyl peptidase iv et procédés |
EP1971614A1 (fr) | 2005-11-14 | 2008-09-24 | Probiodrug AG | Derives de pyrrolidine a fusion de cyclopropyle, en tant qu'inhibiteurs de dipeptidyle peptidase iv (dp iv) |
WO2007063928A1 (fr) | 2005-11-30 | 2007-06-07 | Toray Industries, Inc. | Nouveau derive non cyclique d’amine carboxamide et sel de celui-ci |
-
2011
- 2011-09-12 WO PCT/IN2011/000621 patent/WO2012035549A2/fr active Application Filing
- 2011-09-12 IN IN2164DE2010 patent/IN2010DE02164A/en unknown
- 2011-09-13 AR ARP110103328A patent/AR082971A1/es unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004058266A1 (fr) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | Derives de 3-amino-4-phenylbutanoique acide utilises en tant qu'inhibiteurs de dipeptidyl peptidase pour le traitement ou la prevention du diabete |
WO2006104997A2 (fr) * | 2005-03-29 | 2006-10-05 | Merck & Co., Inc. | Sels d'acide tartarique d'un inhibiteur de la dipeptidyl peptidase iv |
WO2009093269A1 (fr) * | 2008-01-24 | 2009-07-30 | Panacea Biotec Limited | Nouveaux composés hétérocycliques |
WO2010097420A1 (fr) * | 2009-02-25 | 2010-09-02 | Esteve Química, S.A. | Procédé de préparation d'un dérivé béta aminoacide chiral et intermédiaires utilisés dans ledit procédé |
Non-Patent Citations (3)
Title |
---|
KIM DOOSEOP ET AL: "(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]py razin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 48, no. 1, 13 January 2005 (2005-01-13), pages 141 - 151, XP002557878, ISSN: 0022-2623, [retrieved on 20041213], DOI: 10.1021/JM0493156 * |
KIM ET AL: "Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA(TM) (sitagliptin phosphate)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 12, 15 June 2007 (2007-06-15), pages 3373 - 3377, XP022097786, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.03.098 * |
ROLF PAUL ET AL: "N,N'-Carbonyldiimidazole, a new peptide forming reagent", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC; US, vol. 82, no. 5, 1 January 1960 (1960-01-01), pages 4596 - 4600, XP002202500, ISSN: 0002-7863, DOI: 10.1021/JA01502A038 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012035549A2 (fr) | 2012-03-22 |
IN2010DE02164A (fr) | 2015-07-24 |
AR082971A1 (es) | 2013-01-23 |
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