WO2012025637A9 - An agglutination assay method and device - Google Patents
An agglutination assay method and device Download PDFInfo
- Publication number
- WO2012025637A9 WO2012025637A9 PCT/EP2011/064841 EP2011064841W WO2012025637A9 WO 2012025637 A9 WO2012025637 A9 WO 2012025637A9 EP 2011064841 W EP2011064841 W EP 2011064841W WO 2012025637 A9 WO2012025637 A9 WO 2012025637A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lateral flow
- agglutination
- flow assay
- sample
- monitoring
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
- G01N2333/4613—Snake venom
Abstract
The present invention is directed to a method and device for monitoring and measuring agglutination within a sample using a lateral flow assay device. In particular, the present invention is directed to a method for monitoring and measuring the onset of agglutination within a sample on a lateral flow assay device comprising micro-projections to define a lateral flow assay path wherein the method comprises combining the sample with at least one detectable marker and at least one agglutination marker or a combination thereof to form a labelled sample; subjecting the labelled sample to lateral flow; and monitoring the redistribution of the agglutination marker through the lateral flow assay path as agglutination occurs. The invention is also directed to a lateral flow assay device for carrying out the method and a kit comprising the lateral flow assay device and detection means.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1014316.2 | 2010-08-27 | ||
GBGB1014316.2A GB201014316D0 (en) | 2010-08-27 | 2010-08-27 | A agglutination assay method and device |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012025637A1 WO2012025637A1 (en) | 2012-03-01 |
WO2012025637A9 true WO2012025637A9 (en) | 2012-05-18 |
Family
ID=43013346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2011/064841 WO2012025637A1 (en) | 2010-08-27 | 2011-08-29 | An agglutination assay method and device |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB201014316D0 (en) |
WO (1) | WO2012025637A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8845979B2 (en) * | 2010-09-14 | 2014-09-30 | California Institute Of Technology | Thermal blood clot formation and use in microfluidic device valving applications |
CA3129014A1 (en) * | 2012-11-15 | 2014-05-15 | Ortho-Clinical Diagnostics, Inc. | Quality/process control of a lateral flow assay device based on flow monitoring |
TWI500921B (en) * | 2013-01-14 | 2015-09-21 | Ind Tech Res Inst | Optical sensing chip |
US10073091B2 (en) | 2014-08-08 | 2018-09-11 | Ortho-Clinical Diagnostics, Inc. | Lateral flow assay device |
DE102015222787A1 (en) * | 2015-11-18 | 2017-05-18 | Siemens Healthcare Diagnostics Products Gmbh | Platelet function analysis system |
JP2022528364A (en) * | 2019-03-27 | 2022-06-10 | ハエモキネシス・リミテッド | Methods and Devices for Measuring Fibrinogen Concentrations in Blood Samples |
CN113395582B (en) * | 2020-03-12 | 2023-04-07 | 平湖莱顿光学仪器制造有限公司 | Transmittance-related intelligent two-dimensional video playing method and video device thereof |
CN111856042A (en) * | 2020-07-31 | 2020-10-30 | 深圳微点生物技术股份有限公司 | Device for detecting blood coagulation characteristics and application thereof |
CN113740326B (en) * | 2021-09-06 | 2022-04-29 | 中国人民解放军军事科学院军事医学研究院 | Device and method for rapidly detecting concentration of fibrinogen in whole blood |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5469497A (en) | 1977-11-12 | 1979-06-04 | Kyoto Daiichi Kagaku Kk | Method and device for measuring blood solidification time |
US4963498A (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
US4849340A (en) | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
US5039617A (en) | 1989-04-20 | 1991-08-13 | Biotrack, Inc. | Capillary flow device and method for measuring activated partial thromboplastin time |
US5302348A (en) | 1992-12-10 | 1994-04-12 | Itc Corporation | Blood coagulation time test apparatus and method |
US5908786A (en) | 1997-12-12 | 1999-06-01 | Akzo Nobel, N.V. | Blood coagulation monitoring device with liquid crystal and gradient heater |
SE0201738D0 (en) | 2002-06-07 | 2002-06-07 | Aamic Ab | Micro-fluid structures |
SE0400662D0 (en) | 2004-03-24 | 2004-03-24 | Aamic Ab | Assay device and method |
SE0501418L (en) | 2005-06-20 | 2006-09-26 | Aamic Ab | Method and means for effecting liquid transport |
CA2689170A1 (en) * | 2007-06-20 | 2008-12-24 | Mec Dynamics Corporation | Methods and apparatus for measuring blood coagulation |
US20090208975A1 (en) * | 2007-12-13 | 2009-08-20 | Beckman Coulter, Inc. | Device and methods for detecting a target cell |
-
2010
- 2010-08-27 GB GBGB1014316.2A patent/GB201014316D0/en not_active Ceased
-
2011
- 2011-08-29 WO PCT/EP2011/064841 patent/WO2012025637A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2012025637A1 (en) | 2012-03-01 |
GB201014316D0 (en) | 2010-10-13 |
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