WO2012021042A3 - 대장암 진단용 저질량 이온 결정 방법 및 이를 이용한 대장암 진단 방법 - Google Patents

대장암 진단용 저질량 이온 결정 방법 및 이를 이용한 대장암 진단 방법 Download PDF

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Publication number
WO2012021042A3
WO2012021042A3 PCT/KR2011/005974 KR2011005974W WO2012021042A3 WO 2012021042 A3 WO2012021042 A3 WO 2012021042A3 KR 2011005974 W KR2011005974 W KR 2011005974W WO 2012021042 A3 WO2012021042 A3 WO 2012021042A3
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WIPO (PCT)
Prior art keywords
colorectal cancer
diagnosing colorectal
low mass
mass ions
same
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PCT/KR2011/005974
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English (en)
French (fr)
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WO2012021042A2 (ko
Inventor
유병철
김인후
김경희
이준화
김광기
장희진
김대용
오재환
김병창
박지원
김선영
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국립암센터
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Publication date
Application filed by 국립암센터 filed Critical 국립암센터
Priority to EP11816658.6A priority Critical patent/EP2623983B1/en
Priority to US13/816,560 priority patent/US9640375B2/en
Publication of WO2012021042A2 publication Critical patent/WO2012021042A2/ko
Publication of WO2012021042A3 publication Critical patent/WO2012021042A3/ko

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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Data Mining & Analysis (AREA)
  • Theoretical Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Software Systems (AREA)
  • Evolutionary Biology (AREA)
  • Databases & Information Systems (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computing Systems (AREA)
  • Evolutionary Computation (AREA)

Abstract

본 발명은 MALDI-TOF 질량분석기 등을 이용하여 생물학적 시료로부터 추출한 저질량 이온에 대해 생물통계학적 분석을 하여 대장암 진단을 위한 저질량 이온을 결정하고, 이를 이용하여 대장암 진단을 위한 정보를 제공하기 위한 방법을 제시한다. 본 발명에 의해 분석 비용이 매우 낮으며, 분석 시간이 짧고, 대규모 분석이 가능하며, 판별 성능이 우수하고 강건한 진단 방법을 제공할 수 있다.
PCT/KR2011/005974 2010-08-12 2011-08-12 대장암 진단용 저질량 이온 결정 방법 및 이를 이용한 대장암 진단 방법 WO2012021042A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11816658.6A EP2623983B1 (en) 2010-08-12 2011-08-12 Method for crystallizing low mass ions for diagnosing colorectal cancer and method for diagnosing colorectal cancer using same
US13/816,560 US9640375B2 (en) 2010-08-12 2011-08-12 Method for crystallizing low mass ions for diagnosing colorectal cancer and method for diagnosing colorectal cancer using same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2010-0078017 2010-08-12
KR20100078017 2010-08-12
KR1020100100473A KR101223270B1 (ko) 2010-08-12 2010-10-14 대장암 진단용 저질량 이온 결정 방법, 이를 이용하여 대장암 진단을 위한 정보를 제공하는 방법, 및 이를 위한 연산 장치
KR10-2010-0100473 2010-10-14

Publications (2)

Publication Number Publication Date
WO2012021042A2 WO2012021042A2 (ko) 2012-02-16
WO2012021042A3 true WO2012021042A3 (ko) 2012-05-31

Family

ID=45838524

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/005974 WO2012021042A2 (ko) 2010-08-12 2011-08-12 대장암 진단용 저질량 이온 결정 방법 및 이를 이용한 대장암 진단 방법

Country Status (4)

Country Link
US (1) US9640375B2 (ko)
EP (1) EP2623983B1 (ko)
KR (1) KR101223270B1 (ko)
WO (1) WO2012021042A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101389382B1 (ko) * 2013-05-20 2014-04-29 국립암센터 인지질을 이용한 암의 진단 방법
KR101552011B1 (ko) 2013-08-21 2015-09-09 이화여자대학교 산학협력단 리소포스파티딜콜린 및 호모시스테인산을 포함하는 난소암 진단용 조성물 및 이를 사용하여 난소암을 진단하는 방법
CA2966315A1 (en) * 2014-10-30 2016-05-06 Dh Technologies Development Pte. Ltd. Methods and systems for selecting ions for ion fragmentation
KR20160104330A (ko) 2015-02-26 2016-09-05 국립암센터 난소암 진단 장치와 난소암 진단 정보 제공 방법
CN112614550B (zh) * 2020-12-17 2024-03-15 华东理工大学 一种基于神经网络的分子筛x射线衍射图谱峰位置的预测方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070138385A1 (en) * 2005-12-05 2007-06-21 The Regents Of The University Of California Time-of-flight secondary ion mass spectrometer mapping of cells and tissue
KR20090122638A (ko) * 2008-05-26 2009-12-01 한국표준과학연구원 비행시간이차이온질량분광법을 이용한 질병의 진단 방법,질병 지표의 스크린 방법, 및 질병 지표

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2526878A1 (en) 2003-04-08 2004-10-21 Colotech A/S A method for detection of colorectal cancer in human samples
WO2006125021A2 (en) * 2005-05-16 2006-11-23 Dana Farber Cancer Institute, Inc. Fibrinogen alpha and hemoglobin polypeptides as cancer markers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070138385A1 (en) * 2005-12-05 2007-06-21 The Regents Of The University Of California Time-of-flight secondary ion mass spectrometer mapping of cells and tissue
KR20090122638A (ko) * 2008-05-26 2009-12-01 한국표준과학연구원 비행시간이차이온질량분광법을 이용한 질병의 진단 방법,질병 지표의 스크린 방법, 및 질병 지표

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DAVIS M.T. ET AL.: "Cancer biomarker discovery via low molecular weight serum profiling - Are we following circular paths?", CLINICAL CHEMISTRY, vol. 56, no. 2, 2010, pages 244 - 247, XP055095508 *
SEIBERT V. ET AL.: "Advances in clinical cancer proteomics: SELDI-ToF-Mass spectrometry and biomarker discovery.", BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS., vol. 4, no. 1, 2005, pages 16 - 26, XP055082365 *
WARD D. G. ET AL.: "Proteomic profiling of urine for the detection of colon cancer.", PROTEOME SCIENCE., vol. 6, no. 19, 2008, pages 1 - 15, XP002551797 *

Also Published As

Publication number Publication date
KR20120015978A (ko) 2012-02-22
EP2623983A2 (en) 2013-08-07
US9640375B2 (en) 2017-05-02
EP2623983A4 (en) 2014-03-26
WO2012021042A2 (ko) 2012-02-16
EP2623983B1 (en) 2016-01-06
US20130206977A1 (en) 2013-08-15
KR101223270B1 (ko) 2013-01-17

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