WO2012010651A3 - Method for the preparation of omega-amino-alkaneamides and omega-amino-alkanethioamides as well as intermediates of this method - Google Patents

Method for the preparation of omega-amino-alkaneamides and omega-amino-alkanethioamides as well as intermediates of this method Download PDF

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Publication number
WO2012010651A3
WO2012010651A3 PCT/EP2011/062497 EP2011062497W WO2012010651A3 WO 2012010651 A3 WO2012010651 A3 WO 2012010651A3 EP 2011062497 W EP2011062497 W EP 2011062497W WO 2012010651 A3 WO2012010651 A3 WO 2012010651A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino
omega
preparation
intermediates
alkanethioamides
Prior art date
Application number
PCT/EP2011/062497
Other languages
French (fr)
Other versions
WO2012010651A2 (en
Inventor
Martin Albert
Dominic De Souza
Martin Langner
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of WO2012010651A2 publication Critical patent/WO2012010651A2/en
Publication of WO2012010651A3 publication Critical patent/WO2012010651A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Abstract

The present invention relates to method for the preparation of an ω-amino-alkane(thio)amide having the formula (3). Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.
PCT/EP2011/062497 2010-07-23 2011-07-21 Method for the preparation of omega-amino-alkaneamides and omega-amino-alkanethioamides as well as intermediates of this method WO2012010651A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10170670.3 2010-07-23
EP10170670 2010-07-23

Publications (2)

Publication Number Publication Date
WO2012010651A2 WO2012010651A2 (en) 2012-01-26
WO2012010651A3 true WO2012010651A3 (en) 2012-04-05

Family

ID=43128355

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/062497 WO2012010651A2 (en) 2010-07-23 2011-07-21 Method for the preparation of omega-amino-alkaneamides and omega-amino-alkanethioamides as well as intermediates of this method

Country Status (1)

Country Link
WO (1) WO2012010651A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107586267B (en) * 2016-11-01 2020-02-18 华东师范大学 Synthetic method of taurine hydrochloride (2-amino ethyl taurine hydrochloride)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931429A (en) * 1987-10-01 1990-06-05 G. D. Searle & Co. α-aminoacyl β-aminoacyl aminodiols as anti-hypertensive agents
AT502804A4 (en) * 2006-02-03 2007-06-15 Dsm Fine Chem Austria Gmbh PROCESS FOR THE PREPARATION OF OMEGA-AMINO-2,2-DIALKYL-C3-C12-ALKANAMIDES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004137245A (en) 2002-08-23 2004-05-13 Kissei Pharmaceut Co Ltd Pyrazole derivative, pharmaceutical composition containing the same, its pharmaceutical use and production intermediate
PE20060416A1 (en) 2004-08-03 2006-06-09 Novartis Ag COMPOSITION OF RENIN INHIBITORS AND EFFUSION PROTEIN INHIBITORS
WO2007071626A2 (en) 2005-12-20 2007-06-28 Basf Se Method for the production of aminoalkane acid amides
CN100588646C (en) 2005-12-27 2010-02-10 上海药明康德新药开发有限公司 Industrial preparation method for 3-amino-2, 2-dimethyl propionamide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931429A (en) * 1987-10-01 1990-06-05 G. D. Searle & Co. α-aminoacyl β-aminoacyl aminodiols as anti-hypertensive agents
AT502804A4 (en) * 2006-02-03 2007-06-15 Dsm Fine Chem Austria Gmbh PROCESS FOR THE PREPARATION OF OMEGA-AMINO-2,2-DIALKYL-C3-C12-ALKANAMIDES

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEDDOW, JAMES E. ET AL: "Asymmetric synthesis of beta2 - amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 5, 25 July 2007 (2007-07-25), pages 2812 - 2825, XP002612477, DOI: 10.1039/b707689d *
BUCKLEY G HEATH R ET AL: "Aliphatic Nitro-compounds. PartXII. Preparation and Reduction of 2-Nitroalkyl Cyanides", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1947 (1947-01-01), pages 1500 - 1503, XP009141963, ISSN: 0368-1769 *
CARRUTHERS N I ET AL: "Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAB receptor affinities", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 8, no. 21, 3 November 1998 (1998-11-03), pages 3059 - 3064, XP004141875, ISSN: 0960-894X, DOI: DOI:10.1016/S0960-894X(98)00565-4 *
DUCRY L ET AL: "SYNTHESIS OF 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND EVALUATION OF THEIR AFFINITY FOR MHC CLASS-II PROTEINS", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA, BASEL, CH, vol. 82, no. 12, 1 January 1999 (1999-01-01), pages 2432 - 2447, XP000978878, ISSN: 0018-019X, DOI: DOI:_ *
MOUMNE ET AL: "One-pot synthesis of beta-amino acid derivatives via addition of bis(O-silyl) ketene acetals on iminium salts", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 47, 24 October 2007 (2007-10-24), pages 8277 - 8280, XP022313012, ISSN: 0040-4039, DOI: DOI:10.1016/J.TETLET.2007.09.119 *

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Publication number Publication date
WO2012010651A2 (en) 2012-01-26

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