WO2012006181A3 - Compositions et procédés pour l'inhibition de micro-arn oncogènes et le traitement du cancer - Google Patents
Compositions et procédés pour l'inhibition de micro-arn oncogènes et le traitement du cancer Download PDFInfo
- Publication number
- WO2012006181A3 WO2012006181A3 PCT/US2011/042436 US2011042436W WO2012006181A3 WO 2012006181 A3 WO2012006181 A3 WO 2012006181A3 US 2011042436 W US2011042436 W US 2011042436W WO 2012006181 A3 WO2012006181 A3 WO 2012006181A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- compositions
- cancer
- treatment
- inhibiting oncogenic
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cette invention concerne des inhibiteurs de micro-ARN et des méthodes pour leur utilisation. Plus particulièrement, l'invention concerne des compositions et des méthodes de traitement de carcinomes hépatocellulaires à l'aide d'inhibiteurs de molécules de micro-ARN surexprimées dans le locus chromosomique 19q13.41 (C19MC).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35977010P | 2010-06-29 | 2010-06-29 | |
US61/359,770 | 2010-06-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012006181A2 WO2012006181A2 (fr) | 2012-01-12 |
WO2012006181A3 true WO2012006181A3 (fr) | 2012-04-26 |
Family
ID=45441752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/042436 WO2012006181A2 (fr) | 2010-06-29 | 2011-06-29 | Compositions et procédés pour l'inhibition de micro-arn oncogènes et le traitement du cancer |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012006181A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011130749A2 (fr) | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification de mutations dans les glycoprotéines d'enveloppe de virus herpès simplex qui permettent ou augmentent le reciblage de vecteur vers de nouveaux récepteurs non-hsv |
RS60318B1 (sr) * | 2012-08-01 | 2020-07-31 | Ikaika Therapeutics Llc | Ublažavanje tkivnog oštećenja i fibroze pomoću anti-ltbp4 antitela |
ES2810800T3 (es) | 2013-10-28 | 2021-03-09 | Univ Pittsburgh Commonwealth Sys Higher Education | Vector de HSV oncolítico |
EA201791644A1 (ru) | 2015-01-20 | 2018-01-31 | Мираджен Терапьютикс, Инк. | Ингибиторы mir-92 и их применение |
RU2749050C2 (ru) | 2016-01-27 | 2021-06-03 | Онкорус, Инк. | Онколитические вирусные векторы и их применение |
WO2017210735A1 (fr) * | 2016-06-07 | 2017-12-14 | Garvan Institute Of Medical Research | Méthodes de traitement du neuroblastome et réactifs à cet effet |
US11427625B2 (en) | 2016-06-14 | 2022-08-30 | University of Pittsburgh—of the Commonwealth System of Higher Education | Expression of NKG2D activating ligand proteins for sensitizing cancer cells to attack by cytotoxic immune cells |
BR112019000015A2 (pt) | 2016-06-30 | 2019-04-24 | Oncorus, Inc. | distribuição por vírus oncolítico pseudotipado de polipeptídeos terapêuticos |
WO2018047148A1 (fr) * | 2016-09-12 | 2018-03-15 | Novartis Ag | Composés pour inhibition du miarn |
EP3589371A4 (fr) * | 2017-03-02 | 2020-11-25 | Youhealth Oncotech, Limited | Marqueurs de méthylation pour diagnostiquer un carcinome hépatocellulaire et un cancer du poumon |
EP3658165A4 (fr) | 2017-07-26 | 2021-09-01 | Oncorus, Inc. | Vecteurs viraux oncolytiques et leurs utilisations |
US11865081B2 (en) | 2017-12-29 | 2024-01-09 | Virogin Biotech Canada Ltd. | Oncolytic viral delivery of therapeutic polypeptides |
CN114480399A (zh) * | 2022-03-17 | 2022-05-13 | 江苏医药职业学院 | 降低CPB1基因表达的siRNA、重组载体及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090105174A1 (en) * | 2007-04-20 | 2009-04-23 | Amgen Inc. | Nucleic acids hybridizable to micro rna and precursors thereof |
US20090220589A1 (en) * | 2008-03-01 | 2009-09-03 | Abraxis Bioscience, Llc | Treatment, diagnostic, and method for discovering antagonist using sparc specific mirnas |
US20090226375A1 (en) * | 2008-02-21 | 2009-09-10 | Eric Olson | MICRO-RNAs THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION AND USES THEREOF |
-
2011
- 2011-06-29 WO PCT/US2011/042436 patent/WO2012006181A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090105174A1 (en) * | 2007-04-20 | 2009-04-23 | Amgen Inc. | Nucleic acids hybridizable to micro rna and precursors thereof |
US20090226375A1 (en) * | 2008-02-21 | 2009-09-10 | Eric Olson | MICRO-RNAs THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION AND USES THEREOF |
US20090220589A1 (en) * | 2008-03-01 | 2009-09-03 | Abraxis Bioscience, Llc | Treatment, diagnostic, and method for discovering antagonist using sparc specific mirnas |
Non-Patent Citations (2)
Title |
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RIPPE ET AL.: "The Two Stem Cell MicroRNA Gene Clusters C19MC and miR-371-3 Are Activated by Specific Chromosomal Rearrangements in a Subgroup of Thyroid Adenomas.", PLOS ONE, vol. 5, no. 3, 3 March 2010 (2010-03-03), pages 1 - 11, XP002607044, DOI: doi:10.1371/JOURNAL.PONE.0009485 * |
TOFFANIN ET AL.: "MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a", GASTROENTEROLOGY, vol. 140, no. 5, May 2011 (2011-05-01), pages 1618 - 1628 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012006181A2 (fr) | 2012-01-12 |
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