WO2012001083A3 - Novel eprinomectin injectable compositions - Google Patents

Novel eprinomectin injectable compositions Download PDF

Info

Publication number
WO2012001083A3
WO2012001083A3 PCT/EP2011/060969 EP2011060969W WO2012001083A3 WO 2012001083 A3 WO2012001083 A3 WO 2012001083A3 EP 2011060969 W EP2011060969 W EP 2011060969W WO 2012001083 A3 WO2012001083 A3 WO 2012001083A3
Authority
WO
WIPO (PCT)
Prior art keywords
eprinomectin
novel
solvents
injectable compositions
parasiticide
Prior art date
Application number
PCT/EP2011/060969
Other languages
French (fr)
Other versions
WO2012001083A2 (en
Inventor
Hannelie Cilliers
Original Assignee
Ceva Sante Animale Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceva Sante Animale Sa filed Critical Ceva Sante Animale Sa
Priority to RU2013103140/15A priority Critical patent/RU2578036C2/en
Publication of WO2012001083A2 publication Critical patent/WO2012001083A2/en
Publication of WO2012001083A3 publication Critical patent/WO2012001083A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

An improved injectable parasiticide composition for treating infections caused by ectoparasites and endoparasites, wherein the formulation comprises a solvent system comprising polyethylene glycol and optionally other excipients and a pharmaceutically acceptable solvent or mixture of solvents and co-solvents, said novel formulation being capable of improving the bioavailability and residence time of the parasiticide in the treated non human mammals. Preferred compositions according to the invention comprise parasiticides which are macrocyclic lactones having poor liphophilic properties, such as for example eprinomectin.
PCT/EP2011/060969 2010-06-29 2011-06-29 Novel eprinomectin injectable compositions WO2012001083A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2013103140/15A RU2578036C2 (en) 2010-06-29 2011-06-29 New injectable compositions of eprinomectin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35966310P 2010-06-29 2010-06-29
US61/359,663 2010-06-29

Publications (2)

Publication Number Publication Date
WO2012001083A2 WO2012001083A2 (en) 2012-01-05
WO2012001083A3 true WO2012001083A3 (en) 2012-05-24

Family

ID=44629174

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/060969 WO2012001083A2 (en) 2010-06-29 2011-06-29 Novel eprinomectin injectable compositions

Country Status (2)

Country Link
RU (1) RU2578036C2 (en)
WO (1) WO2012001083A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014098623A1 (en) * 2012-12-20 2014-06-26 Alleva Animal Health Limited Injectable eprinomectin formulation and anthelmintic use thereof
BR112016006182B1 (en) * 2013-09-30 2023-01-10 Zoetis Services Llc LONG-LASTING VETERINARY COMPOSITION AND ITS USES
EP3023092A1 (en) * 2014-11-20 2016-05-25 Ceva Sante Animale Eprinomectin parenteral compositions
CN114651961A (en) * 2022-03-25 2022-06-24 浙江科露宝食品有限公司 Medical formula food thickening component and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026895A1 (en) * 1996-01-29 1997-07-31 Gene Komer Avermectin formulation
US20070042013A1 (en) * 2005-08-19 2007-02-22 Soll Mark D Long acting injectable formulations
US20080027011A1 (en) * 2005-12-20 2008-01-31 Hassan Nached Homogeneous paste and gel formulations
WO2009070687A1 (en) * 2007-11-26 2009-06-04 Merial Limited Solvent systems for pour-on formulations for combating parasites

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (en) 1976-04-19 1984-07-16 Merck & Co Inc SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS
AU713580B2 (en) 1995-09-25 1999-12-02 Merial Ltd Anthelmintic macrocyclic lactone compositions
AR045142A1 (en) * 2003-07-30 2005-10-19 Novartis Ag BUEN SABOR DUCTILE MASTICABLE VETERINARY COMPOSITION

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026895A1 (en) * 1996-01-29 1997-07-31 Gene Komer Avermectin formulation
US20070042013A1 (en) * 2005-08-19 2007-02-22 Soll Mark D Long acting injectable formulations
US20080027011A1 (en) * 2005-12-20 2008-01-31 Hassan Nached Homogeneous paste and gel formulations
WO2009070687A1 (en) * 2007-11-26 2009-06-04 Merial Limited Solvent systems for pour-on formulations for combating parasites

Also Published As

Publication number Publication date
WO2012001083A2 (en) 2012-01-05
RU2578036C2 (en) 2016-03-20
RU2013103140A (en) 2014-08-10

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