WO2012000781A3 - 11c-markiertes peptid zur detektion eines tumors, der einen somatostatinrezeptor exprimiert - Google Patents

11c-markiertes peptid zur detektion eines tumors, der einen somatostatinrezeptor exprimiert Download PDF

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Publication number
WO2012000781A3
WO2012000781A3 PCT/EP2011/059845 EP2011059845W WO2012000781A3 WO 2012000781 A3 WO2012000781 A3 WO 2012000781A3 EP 2011059845 W EP2011059845 W EP 2011059845W WO 2012000781 A3 WO2012000781 A3 WO 2012000781A3
Authority
WO
WIPO (PCT)
Prior art keywords
somatostatin receptor
tumour
expresses
detecting
labelled peptide
Prior art date
Application number
PCT/EP2011/059845
Other languages
English (en)
French (fr)
Other versions
WO2012000781A2 (de
Inventor
Hartmuth C. Kolb
Ursus KRÜGER
Oliver Lade
Arno Steckenborn
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Aktiengesellschaft filed Critical Siemens Aktiengesellschaft
Publication of WO2012000781A2 publication Critical patent/WO2012000781A2/de
Publication of WO2012000781A3 publication Critical patent/WO2012000781A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Es wird die Verwendung eines Peptids (1) zur Herstellung eines Agens zur Detektion eines Tumors (18), der einen Somatostatinrezeptor (4) exprimiert, beschrieben. Das Peptid (1) bindet an den Somatostatinrezeptor (4) und weist ein 11C-Kohlenstoffatom auf. Ferner wird ein Radiopharmakon zur Lokalisation eines Tumors (18), der einen Somatostatinrezeptor (4) exprimiert, beschrieben. Dieses umfasst ein Peptid (1), das an den Somatostatinrezeptor (4) bindet und ein 11C-Kohlenstoffatom aufweist.
PCT/EP2011/059845 2010-06-30 2011-06-14 11c-markiertes peptid zur detektion eines tumors, der einen somatostatinrezeptor exprimiert WO2012000781A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010026060.6 2010-06-30
DE201010026060 DE102010026060A1 (de) 2010-06-30 2010-06-30 11C-markiertes Peptid zur Detektion eines Tumors, der einen Somatostatinrezeptor exprimiert

Publications (2)

Publication Number Publication Date
WO2012000781A2 WO2012000781A2 (de) 2012-01-05
WO2012000781A3 true WO2012000781A3 (de) 2012-03-08

Family

ID=44627699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/059845 WO2012000781A2 (de) 2010-06-30 2011-06-14 11c-markiertes peptid zur detektion eines tumors, der einen somatostatinrezeptor exprimiert

Country Status (2)

Country Link
DE (1) DE102010026060A1 (de)
WO (1) WO2012000781A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011012414A1 (de) * 2009-07-29 2011-02-03 Siemens Aktiengesellschaft Verfahren zur herstellung eines radioaktiv markierten peptids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2526556C (en) * 2003-07-24 2012-09-25 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
DE102009035648B3 (de) 2009-07-29 2011-03-17 Siemens Aktiengesellschaft Verfahren zur Herstellung eines radioaktiv markierten Carboxylats sowie die Verwendung einer Mikroelektrode zur elektrochemischen Synthese eines radioaktiv markierten Carboxylats

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011012414A1 (de) * 2009-07-29 2011-02-03 Siemens Aktiengesellschaft Verfahren zur herstellung eines radioaktiv markierten peptids

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HENRIKSEN G ET AL: "Proof of principle for the use of 11C-labelled peptides in tumour diagnosis with PET", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER VERLAG, HEIDELBERG, DE, vol. 31, no. 12, 10 August 2004 (2004-08-10), pages 1653 - 1657, XP002383248, ISSN: 1619-7070, DOI: 10.1007/S00259-004-1582-1 *
SANDELL J ET AL: "Labelling of a cholecystokinin (CCK) peptide with 11C, and examination of its brain uptake in a cynomolgus monkey with PET", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 40, 1 December 1997 (1997-12-01), pages 771 - 773, XP002663002, ISSN: 0362-4803 *
SCHIRRMACHER R ET AL: "Rapid in situ synthesis of [<11>C]methyl azide and its application in <11>C click-chemistry", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 49, no. 33, 11 August 2008 (2008-08-11), pages 4824 - 4827, XP022819091, ISSN: 0040-4039, [retrieved on 20080610], DOI: 10.1016/J.TETLET.2008.06.020 *

Also Published As

Publication number Publication date
WO2012000781A2 (de) 2012-01-05
DE102010026060A1 (de) 2012-01-05

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