WO2011156557A3 - Compounds active at the neurotensin receptor - Google Patents

Compounds active at the neurotensin receptor Download PDF

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Publication number
WO2011156557A3
WO2011156557A3 PCT/US2011/039731 US2011039731W WO2011156557A3 WO 2011156557 A3 WO2011156557 A3 WO 2011156557A3 US 2011039731 W US2011039731 W US 2011039731W WO 2011156557 A3 WO2011156557 A3 WO 2011156557A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
treating
neurotensin receptor
compounds active
providing
Prior art date
Application number
PCT/US2011/039731
Other languages
French (fr)
Other versions
WO2011156557A2 (en
Inventor
James B. Thomas
Scott P. Runyon
Original Assignee
Thomas James B
Runyon Scott P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas James B, Runyon Scott P filed Critical Thomas James B
Publication of WO2011156557A2 publication Critical patent/WO2011156557A2/en
Publication of WO2011156557A3 publication Critical patent/WO2011156557A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

The present invention relates to compounds that are active at neurotensin receptors and represented by the formula:(I) where the structural variables are defined herein. The compounds can be used for a variety of therapies, including modulating dopamine transmission, treating Parkinsons disease, preventing a relapse to drug seeking, providing an antipsychotic effect, providing neuroprotection, treating pain, treating cancer, and inhibiting cancer progression.
PCT/US2011/039731 2010-06-11 2011-06-09 Compounds active at the neurotensin receptor WO2011156557A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35389710P 2010-06-11 2010-06-11
US61/353,897 2010-06-11

Publications (2)

Publication Number Publication Date
WO2011156557A2 WO2011156557A2 (en) 2011-12-15
WO2011156557A3 true WO2011156557A3 (en) 2012-02-02

Family

ID=45098661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/039731 WO2011156557A2 (en) 2010-06-11 2011-06-09 Compounds active at the neurotensin receptor

Country Status (1)

Country Link
WO (1) WO2011156557A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109320502A (en) * 2012-12-07 2019-02-12 3B制药有限公司 Neurotensin receptor ligand

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR094929A1 (en) 2013-02-28 2015-09-09 Bristol Myers Squibb Co DERIVATIVES OF PHENYLPIRAZOL AS POWERFUL INHIBITORS OF ROCK1 AND ROCK2
JP6423372B2 (en) 2013-02-28 2018-11-14 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
US20170174633A1 (en) * 2014-03-25 2017-06-22 Research Triangle Institute Pyrazole compounds selective for neurotensin 2 receptor
AU2015269247B2 (en) * 2014-06-06 2019-10-24 Research Triangle Institute Apelin receptor (APJ) agonists and uses thereof
US10100059B2 (en) * 2015-12-09 2018-10-16 Research Triangle Institute Apelin receptor (APJ) agonists and uses thereof
US11319299B2 (en) 2016-03-01 2022-05-03 Propellon Therapeutics Inc. Substituted carboxamides as inhibitors of WDR5 protein-protein binding
EP3423437A4 (en) 2016-03-01 2019-07-24 Propellon Therapeutics Inc. Inhibitors of wdr5 protein-protein binding
EP3279197A1 (en) 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis, treatment and prevention of neurotensin receptor-related conditions
AU2017343638B2 (en) 2016-10-12 2021-12-09 Research Triangle Institute Heterocyclic apelin receptor (APJ) agonists and uses thereof
KR20220087497A (en) 2019-10-18 2022-06-24 더 리전츠 오브 더 유니버시티 오브 캘리포니아 Compounds and methods for targeting pathogenic blood vessels
EP3981394A1 (en) * 2020-10-07 2022-04-13 Insusense ApS A sortilin antagonist for use in the prevention or treatment of hearing loss.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420141A (en) * 1990-08-20 1995-05-30 Sanofi 3-amidopyrazole derivatives, process for preparing these and pharmaceutical composites containing them
US6699832B2 (en) * 2000-04-27 2004-03-02 Pfizer Inc. Methods of treating obesity using a neurotensin receptor ligand

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420141A (en) * 1990-08-20 1995-05-30 Sanofi 3-amidopyrazole derivatives, process for preparing these and pharmaceutical composites containing them
US6699832B2 (en) * 2000-04-27 2004-03-02 Pfizer Inc. Methods of treating obesity using a neurotensin receptor ligand

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YUAN ET AL.: "'Structural Modifications of (1S;3S)-3-Amino-4- Difluoromethylene cyclopentanecarboxylic Acid, a Potent Irreversible Inhibitor of GABA Aminotransferase", BIOORG MED CHEM LETT., vol. 17, no. 6, 15 March 2007 (2007-03-15), pages 1651 - 1654 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109320502A (en) * 2012-12-07 2019-02-12 3B制药有限公司 Neurotensin receptor ligand
CN109320502B (en) * 2012-12-07 2022-06-07 3B制药有限公司 Neurotensin receptor ligands

Also Published As

Publication number Publication date
WO2011156557A2 (en) 2011-12-15

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