WO2011153513A3 - Nanoemulsion composition containing vitamin k - Google Patents

Nanoemulsion composition containing vitamin k Download PDF

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Publication number
WO2011153513A3
WO2011153513A3 PCT/US2011/039188 US2011039188W WO2011153513A3 WO 2011153513 A3 WO2011153513 A3 WO 2011153513A3 US 2011039188 W US2011039188 W US 2011039188W WO 2011153513 A3 WO2011153513 A3 WO 2011153513A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoemulsion composition
composition containing
containing vitamin
nanoemulsion
usp
Prior art date
Application number
PCT/US2011/039188
Other languages
French (fr)
Other versions
WO2011153513A2 (en
Inventor
Andrew X. Chen
Original Assignee
Latitude Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Latitude Pharma filed Critical Latitude Pharma
Priority to CN201180027377.0A priority Critical patent/CN102939077B/en
Publication of WO2011153513A2 publication Critical patent/WO2011153513A2/en
Publication of WO2011153513A3 publication Critical patent/WO2011153513A3/en
Priority to US13/688,161 priority patent/US9370486B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

In certain embodiments, this invention sets forth compositions, methods, and uses regarding a nanoemulsion composition that comprises a fat-soluble vitamin K and can therapeutically replace Phytonadione Injectable Emulsion, USP.
PCT/US2011/039188 2010-06-03 2011-06-03 Nanoemulsion composition containing vitamin k WO2011153513A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201180027377.0A CN102939077B (en) 2010-06-03 2011-06-03 Nano-emulsion composition containing vitamin K
US13/688,161 US9370486B2 (en) 2010-06-03 2012-11-28 Nanoemulsion composition containing vitamin K

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35098610P 2010-06-03 2010-06-03
US61/350,986 2010-06-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/688,161 Continuation US9370486B2 (en) 2010-06-03 2012-11-28 Nanoemulsion composition containing vitamin K

Publications (2)

Publication Number Publication Date
WO2011153513A2 WO2011153513A2 (en) 2011-12-08
WO2011153513A3 true WO2011153513A3 (en) 2012-04-26

Family

ID=45067333

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/039188 WO2011153513A2 (en) 2010-06-03 2011-06-03 Nanoemulsion composition containing vitamin k

Country Status (3)

Country Link
US (1) US9370486B2 (en)
CN (1) CN102939077B (en)
WO (1) WO2011153513A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011153513A2 (en) 2010-06-03 2011-12-08 Latitude Pharma Nanoemulsion composition containing vitamin k
US9668974B2 (en) 2012-05-10 2017-06-06 Painreform Ltd. Depot formulations of a local anesthetic and methods for preparation thereof
MX2015004703A (en) * 2012-10-16 2015-10-12 Genspera Inc Injectable cancer compositions.
KR101951933B1 (en) * 2013-03-12 2019-02-25 주식회사 아리바이오 Lipid nonomaterials comprising lysophosphatidylcholine or its derivative and Methods for preparing the same
US20140275261A1 (en) 2013-03-15 2014-09-18 Dr. Reddy's Laboratories, Inc. Diclofenac parenteral compositions
CN103315957A (en) * 2013-06-27 2013-09-25 海南卫康制药(潜山)有限公司 Vitamin K1 lyophilized oral emulsion and preparation method thereof
WO2016038626A1 (en) * 2014-09-12 2016-03-17 Emcure Pharmaceuticals Limited Pharmaceutical compositions of vitamin kl
CN104224713A (en) * 2014-09-17 2014-12-24 句容亿格纳米材料厂 Vitamin B and vitamin K composite nanoemulsion as well as preparation method thereof
EP3200769A4 (en) * 2014-09-29 2018-08-01 Barrie Tan Non-synthetic emulsion-based lipid formulations and methods of use
US11096907B2 (en) * 2015-02-27 2021-08-24 Exela Holdings, Inc. Phytonadione compositions and related methods
US10028921B1 (en) * 2015-02-27 2018-07-24 Exela Holdings, Inc Phytonadione compositions and related methods
CN110496101A (en) * 2016-06-24 2019-11-26 广东双骏生物科技有限公司 A kind of stable vitamin K2Submicron Emulsion and preparation method thereof
CN108938607A (en) * 2017-05-18 2018-12-07 中国人民解放军军事医学科学院毒物药物研究所 A kind of vitamin K composition and preparation method thereof, preparation and purposes
US11382885B2 (en) 2017-06-07 2022-07-12 The Regents Of The University Of California Compositions for treating fungal and bacterial biofilms and methods of using the same
EP3583954A1 (en) * 2018-06-19 2019-12-25 neubourg skin care GmbH Nanodispersions of birch bark extract, electrospun fibers containing such nanodispersions and their use for the treatment of wounds
CN109806226B (en) * 2019-03-16 2021-07-23 西安安健药业有限公司 Application of vitamin K1 fat emulsion injection
CN109758423B (en) * 2019-03-16 2021-06-18 西安安健药业有限公司 Method for treating blood coagulation dysfunction by using vitamin K1 fat emulsion injection
CA3081963A1 (en) 2019-05-31 2020-11-30 American River Nutrition, Llc Compositions comprising quillaja extract and methods of preparations and use thereof
CN110237034A (en) * 2019-06-17 2019-09-17 宁波海奇合昇环能科技有限公司 A kind of preparation method of the transparent aqueous dispersions of fat-soluble nutrients medicine
CN111317716B (en) * 2020-03-11 2022-08-23 青岛农业大学 Vitamin K 1 The colitis hemostatic repair emulsion
JP7510162B2 (en) 2020-08-10 2024-07-03 池田食研株式会社 Emulsion containing fat-soluble vitamins
CN116367822A (en) 2020-08-11 2023-06-30 希普拉有限公司 Phytomenadione composition
WO2023072714A1 (en) * 2021-10-27 2023-05-04 Fresenius Kabi Austria Gmbh Phytonadione for parenteral administration

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01113315A (en) * 1987-10-23 1989-05-02 Lederle Japan Ltd Fat emulsion containing vitamin k2
US5023271A (en) * 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
US20020107265A1 (en) * 1999-10-18 2002-08-08 Feng-Jing Chen Emulsion compositions for polyfunctional active ingredients
US20030170187A1 (en) * 2002-03-01 2003-09-11 Alfred Marchal Skin treatments containing nano-sized vitamin K
US20070190064A1 (en) * 2003-02-05 2007-08-16 N.V. Nutricia Enteral composition for the prevention and/or treatment of sepis
WO2009067734A1 (en) * 2007-11-28 2009-06-04 Commonwealth Scientific And Industrial Research Organisation Nanoemulsions

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JPS6025918A (en) 1983-07-25 1985-02-08 Ajinomoto Co Inc Aqueous solution containing fat-soluble drug
EP0331755B2 (en) * 1987-09-07 2003-02-05 Teijin Limited Medicine-containing fat emulsion of the type prepared immediately before use and process for preparing medicine-containing fat emulsion
JPH01143830A (en) * 1987-12-01 1989-06-06 Nippon Seiyaku Kk Emulsion for vitamin k-containing injection
US5180747A (en) 1989-02-28 1993-01-19 Nisshin Flour Milling Co., Ltd. Stabilized fat-soluble vitamin compositions
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
CN1179913A (en) * 1996-10-14 1998-04-29 巴斯福股份公司 Stable emulsions and dry powders of mixtures of fat-soluble vitamins, their preparation and use
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US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
CN101161238A (en) * 2007-11-20 2008-04-16 东南大学 A lipid nanometer microcapsule based on phospholipids and method for preparing the same
WO2011153513A2 (en) 2010-06-03 2011-12-08 Latitude Pharma Nanoemulsion composition containing vitamin k

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
US5023271A (en) * 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
JPH01113315A (en) * 1987-10-23 1989-05-02 Lederle Japan Ltd Fat emulsion containing vitamin k2
US20020107265A1 (en) * 1999-10-18 2002-08-08 Feng-Jing Chen Emulsion compositions for polyfunctional active ingredients
US20030170187A1 (en) * 2002-03-01 2003-09-11 Alfred Marchal Skin treatments containing nano-sized vitamin K
US20070190064A1 (en) * 2003-02-05 2007-08-16 N.V. Nutricia Enteral composition for the prevention and/or treatment of sepis
WO2009067734A1 (en) * 2007-11-28 2009-06-04 Commonwealth Scientific And Industrial Research Organisation Nanoemulsions

Also Published As

Publication number Publication date
CN102939077B (en) 2016-04-06
US9370486B2 (en) 2016-06-21
WO2011153513A2 (en) 2011-12-08
CN102939077A (en) 2013-02-20
US20130189316A1 (en) 2013-07-25

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