CN1179913A - Stable emulsions and dry powders of mixtures of fat-soluble vitamins, their preparation and use - Google Patents

Stable emulsions and dry powders of mixtures of fat-soluble vitamins, their preparation and use Download PDF

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CN1179913A
CN1179913A CN97122804A CN97122804A CN1179913A CN 1179913 A CN1179913 A CN 1179913A CN 97122804 A CN97122804 A CN 97122804A CN 97122804 A CN97122804 A CN 97122804A CN 1179913 A CN1179913 A CN 1179913A
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vitamin
stable
emulsion
words
dry powder
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W·哈恩莱恩
M·M·汉森
J·E·奥利森
A·G·托拜尔森
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BASF SE
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BASF SE
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Abstract

The present invention relates to stable emulsions and dry powders of mixtures of fat-soluble vitamins, and to processes for their preparation and to their use.

Description

The stable emulsion of mixtures of fat-soluble vitamins and dry powder and its production and use
The present invention relates to the stable emulsion and the dry powder of novel mixtures of fat-soluble vitamins, and their preparation method and their purposes.
Liposoluble vitamin is being played the part of important role aspect the nutrition of humans and animals.These lipophilic reagents exist with its pure form usually because they are readily oxidizable substances, so they deal with or difficulty, or according to not handling.And the fine dispersion of mentioned reagent is of value to and reaches the optimal absorption rate, so best bioavailability is arranged.Therefore these materials are often with the form of emulsion, preferably the form with dry powder provides, and wherein the form that mentioned reagent both can be pure also can be used as the physiological tolerance oil solution and enters in the protecting colloid with finely divided form.
Liposoluble vitamin dry powder can be made by prescription according to the document disclosed method, especially comprehensively describing is at R.A.Morton, Fat Soluble Vitamins, Intern.Encyelopedia ofFood and Nutrition, Volume 9, Pergamon Press 1970, the 134-139 page or leaf.These must make liposoluble vitamin be emulsified into water conservation colloidal solution, and homogenizing is (suitable words are under the situation that coating exists) drying also subsequently.
Often the protecting colloid that uses is a biopolymer.Be disclosed in patent DE-A-1123084, US2756177, US4670247 and EP-A-0285682 are among EP-A-0565989 and the DE-A-4424085, for example gelatin, gum arabic, starch, lignin or other parts hydrolytic soya bean protein and other material of obtaining from natural resources.Simultaneously, the compilation that is purchased protecting colloid sees R.A.Morton, Fat Soluble Vitamins, and Intern.Encyclopedia ofFood and Nutrition, Volume 9,1970,130/131 pages of Pergamon Press.
When using its composition to be adapted to the dry powder that comprises mixtures of fat-soluble vitamins of physiological requirement, and wherein separately composition use huge amount in some cases or in a small amount the time, this requirement be met by strict especially preparation.In this case, for the user particularly importantly,, to guarantee that also reagent disperses evenly same in all particles except requiring stability.
An object of the present invention is to provide a kind of method that is used to prepare the stable mixtures of fat-soluble vitamins that exists with the fine dispersion form.And liposoluble vitamin dry powder is provided equally, wherein except the stability that requires, to guarantee that also the reagent in all particles disperses evenly same.
Term " liposoluble vitamin " is with for the object of the invention, specifically comprise vitamin A, D, E and/or K, corresponding provitamin and vitamin derivative for example have the ester of vitamin A, D, E or the K of similar effect, then comprise their derivative and its mixture for the term in claims " vitamin (A, D, E, K) ".
We have found that to the present invention seeks to realize by the method for preparing liposoluble vitamin stable emulsion or stable dry powder, comprising in water emulsification in all cases respectively:
A) vitamin K and
B) mixture of the mixture of vitamin D, vitamin E and vitamin A or inert oil or vitamin A and inert oil, the method that they obtain is:
b 1) vitamin D is dissolved in inert oil and/or vitamin A, mix with vitamin E, or
b 2) vitamin D is added the mixture of vitamin E and vitamin A and/or inert oil,
To a) and b) composition each exist at following material and to carry out emulsification under the situation,
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
Then mix each emulsion, and suitable words under the situation that coating exists dry this mixture to prepare stable vitamin dry powder.
If vitamin mixtures wherein at first mixes liposoluble vitamin by above-mentioned document disclosed method preparation, then be emulsified into water conservation colloidal solution, homogeneous is also final dry, can be observed following phenomenon:
The oily mixture of vitamin K that prepared before emulsifying step and vitamin A and/or vitamin E becomes peony naturally, and this redness is seen from the angle of using and often do not wished to obtain.
And find that in the mixture of vitamin E and vitamin D, the vitamin E amount surpasses 70wt%, then causes vitamin D seriously to decompose.Therefore, the loss of activity about 50% of the vitamin D that for example in the mixture of the vitamin D of the vitamin E of 99.6 weight portions and 0.4 weight portion, records.
Can eliminate the problem of stability by means of method of the present invention now, and control required dry powder color.Therefore, based on the independently on the one hand emulsification of vitamin K, the emulsification of the mixture of vitamin A, D and/or E on the other hand can keep the inherent colour of vitamin.Even if then two kinds of emulsions that make are mixed, can preserve still that it is faint yellow.
Can prevent that according to the present invention the vitamin D activity reduces greatly under the situation that a large amount of vitamin Es exist, it is by at first vitamin D being dissolved in vitamin A and/or the inert oil, then vitamin E is added in the solution that obtains, wherein with respect to the weight portion of vitamin E, the weight portion at least 25% that vitamin A and/or inert oil have, preferably surpass 50%, especially preferably surpass 100%.Be used for the diverse ways of stable vitamin D at another kind, the concentration of vitamin E is at first used 25%wt at least, preferably surpasses vitamin A and/or the inert oil of 50%wt, and " dilution " reduces then vitamin D to be added in this mixture.
For certain application, for example, for colored food or medicine, the stable composition of above-mentioned red vitamin mixtures is favourable.The acquisition of such product is finished by method of the present invention, comprising the mixture of the following material of emulsification in water:
A) mixture of vitamin D, vitamin E and vitamin K and vitamin A or inert oil or vitamin A and inert oil, its acquisition be by:
a 1) vitamin D is dissolved in inert oil and/or vitamin A, and mix with vitamin E and vitamin K, or
a 2) vitamin D is added in the mixture of vitamin E and vitamin K and vitamin A and/or inert oil,
Emulsification is to exist under the situation at following material to carry out:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
And suitable words are under the condition that coating exists, and dry this emulsion is to prepare stable vitamin dry powder.
And this preparation scheme, by step a 1) or a 2) also can guarantee the stability of vitamin D, mixing vitamin E and vitamin K before emulsification are produced the peony oil that its color can characterize the dry powder that obtains after the emulsion that obtains subsequently and the drying.
The composition of the mixtures of fat-soluble vitamins that uses in two kinds of distinct methods according to the present invention is vitamin A and/or the inert oil of 5-90%wt, the vitamin E of 5-90%wt, the vitamin D of 0.01-1%wt and the vitamin k of 0.1-10%wt are 100% for its percent by weight data sum of each component.
A specific embodiments of said method is the vitamin E that vitamin mixtures contains the vitamin A of 25-70%wt and/or inert oil, 30-70%wt, the vitamin D of 0.05-0.4%wt and the vitamin k of 2-8%wt are 100% for its percent by weight data sum of each component.
Because according to above-mentioned two kinds of methods of the present invention; Produce the stable emulsion and the dry powder of the mixture of the mixture of fat-soluble A, D, E and K and liposoluble vitamin D, E and K, to following ternary composition, be vitamin A, D, K, vitamin A, E, K and vitamin A, D, E, solving its stability problem also is purpose of the present invention.
By the following method that is used to prepare stable vitamin emulsion and dry powder, realized the object of the invention, comprising:
1) to the ternary composition of vitamin A, D and K, in water, distinguish emulsification:
A) vitamin K and
B) mixture of vitamin D and vitamin A,
To a) and b) composition each exist at following material and to carry out emulsification under the situation
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
Then mix each emulsion, and suitable words are under there is situation in coating, dry this mixture is to prepare stable vitamin dry powder.
2) for the ternary composition of vitamin A, D and K, emulsification in water:
A) vitamin A, vitamin K and vitamin D mixture are emulsified under the following material existence condition and carry out:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words
And suitable words are under the condition that coating exists, and dry this emulsion is to prepare stable vitamin dry powder.
3) for the ternary composition of vitamin A, E and K, in water, distinguish emulsification:
A) vitamin K and
B) mixture of vitamin A and vitamin E,
To a) and b) composition each exist at following material and to carry out emulsification under the situation:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
Then mix each emulsion, and suitable words are under the condition that coating exists, dry this mixture is to prepare stable vitamin dry powder.
4) for the ternary composition of vitamin A, E and K, emulsification in water:
A) mixture of vitamin A, vitamin E and vitamin K is emulsified under the following material existence condition and carries out:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
And suitable words are under the coating existence condition, and dry this emulsion is to prepare stable vitamin dry powder.
5) for the ternary mixture of vitamin A, D and E, the mixture to following material in water carries out emulsification:
A) vitamin D, the mixture of vitamin E and vitamin A or inert oil or vitamin A and inert oil, its acquisition be by:
a 1) vitamin D is dissolved in inert oil and/or vitamin A, and mix with vitamin E, or
a 2) vitamin D is added in the mixture of vitamin E and vitamin A and/or inert oil,
Emulsification is to carry out under following material existence condition:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
And suitable words are under the coating existence condition, and dry this emulsion is to prepare stable vitamin dry powder.
The method according to this invention 1) and method 2) its composition of mixtures of fat-soluble vitamins of using is the vitamin A of 70-98%wt, the vitamin D of 0.01-1%wt and the vitamin K of 2-30%wt.
In method 3) and 4) in the mixtures of fat-soluble vitamins that uses have vitamin A, the vitamin E of 5-90%wt and the vitamin K of 0.1-10%wt of following composition: 5-90%wt.
The method according to this invention 5) its composition of the vitamin mixtures of Shi Yonging is vitamin A and/or the inert oil of 5-90%wt, the vitamin E of 5-90%wt and the vitamin D of 0.01-1%, for its percent by weight data addition of above-mentioned each component and be 100%.
Be used to prepare all five kinds of diverse ways of the foregoing detailed description of the emulsion of liposoluble vitamin and dry powder, it is by determining to comprise the ternary composition of being made up of vitamin A, D, E and K, cause and to produce stable product, by the emulsification method concrete according to the present invention, its color tunable becomes required color.
When carrying out the method according to this invention, first step is that liposoluble vitamin is mixed, and is A, D, E, K in the vitamin combination; Under the situation of D, E, K, use A, D, E and D and E, at first under the intensification condition, for example about 40 ℃ to 80 ℃, preferred 50 ℃ to 70 ℃ prepare the solution of vitamin Ds in vitamin A and/or inert oil.Remaining vitamin then adds this solution, with its emulsification water inlet protecting colloid solution under 50 ℃ to 70 ℃ conditions.
But also can under said temperature, earlier vitamin E and vitamin A, vitamin K and/or inert oil be mixed, so that reduce the concentration of vitamin E, and at this moment just vitamin D is added this mixture and it is emulsified into water conservation colloidal solution.
When vitamin K exists, the redness of this vitamin emulsion is under the situation of not wishing to obtain, and should be under these conditions respectively the mixture of vitamin K and vitamin A, E and/or D and suitable inert oil be carried out emulsification, mixes these emulsions subsequently.
Be adjusted to 50-300cp at homogeneous with emulsion viscosity by the suitable dilution of water, behind the preferred 70-150cp, in a usual manner emulsion is changed into powder product, for example by spray-drying or by the spraying cooling or by using inertia coating in spray tower internal spraying emulsion, collect the particle that sprayed, and dry on fluid bed.
The stable vitamin dry powder that makes according to the present invention contains vitamin A, vitamin D, vitamin E and/or the vitamin K of 3-40%wt and/or the mixture of inert oil; the protecting colloid of 5-40%wt; the sugar of 0-30%wt and/or sugar alcohol; other additive of the coating of 0-70%wt and suitable words 0-25%wt, each component percent by weight data sum is 100%.
Term " inert oil " means the acceptable oil of physiology, for example the plant fat acid esters of sesame oil, corn oil, cottonseed oil, soya-bean oil or peanut oil and medium chain degree.
The example of the protecting colloid that uses is gelatin, isinglass, starch, dextrin, vegetable protein, pectin, gum arabic, casein, caseinate or their mixture, preferably uses gelatin, gum arabic, vegetable protein and/or converted starch.But polyvinyl alcohol, polyvinylpyrrolidone, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose and alginates also can be expected as preferred protecting colloid.For further details, with reference to R.A.Morton, Fat Soluble Vitamins, Infern.Encyclopedia of Food andNutrition, Volume 9, Pergamon Press 1970,128-131 page or leaf.In order to strengthen the mechanical stability of final products, it is useful adding plasticizer to colloid, for example adds sugar or sugar alcohol, as sucrose, glucose, fructose, lactose, invert sugar, sorbierite, sweet mellow wine, maltodextrin or glycerine.According to the preferred scheme of the inventive method, use sucrose, lactose and/or maltodextrin.
Other can add the additive of coming in to strengthen mentioned reagent oxidative degradation stability is stabilizing agent, for example tert-butyl group hydroxy-methylbenzene, butylhydroxy anisole, ascorbic acid or ethoxyquin (ethoxyquins).They preferably with vitamin, be emulsified into water conservation colloidal solution with the emulsifying agent of add when suitable.The example of operable emulsifying agent is ascorbyl (ascorbyl) palmitate, fatty acid polyglycerol ester, sorbitan fatty acid esters, methyl glycol fatty acid ester or lecithin.
Term coating refers to the compound such as starch and/or starch derivatives and silica and/or silica derivative, and by their help, vitamin dry powder has physical stability.The coating in preferred food product field is starch or starch derivatives, particularly corn or rice starch.
The additive that both can be used as food and medicine according to product of the present invention also can be used as the additive of livestock nutrition.Under certain conditions, directly using the emulsion itself that makes, also is suitable and they need not be changed into dry powder.
Following embodiment explains in detail to the inventive method.
Embodiment 1:
A) preparation of vitamin mixtures:
1.7g (4 * 10 7IU/g) vitamin D 3By under 65 ℃ of stirrings, being dissolved in 500g (1.7 * 10 6The Retinol Palmitate of preheating IU/g), and then under 65 ℃ with the d of 500g (1100IU/g), the vitamin K of 1-alpha-tocopherol and 45g 1Add.
B) preparation of emulsion:
The gum arabic of 2kg and the sucrose of 2kg are dissolved in the 9kg distilled water that places the emulsification container under 65 ℃.Stir after 30 minutes, add vitamin mixtures, and with this mixture homogeneous 2 hours.Then, this emulsion dilute with water is about 100cp until viscosity, and uses starch encapsulated, at the spray tower inner drying.
Obtained to have the pale brown look vitamin dry powder of following vitamin content:
Retinol Palmitate: 91000IU/g
Vitamin D 3: 7090IU/g
Vitamin K 1: 0.41%
D, 1-alpha-tocopherol: 4.88%
Embodiment 2
A) preparation of vitamin mixtures
1.7g (4 * 10 7IU/g) vitamin D 3By under 65 ℃ of stirrings, being dissolved in the d of 500g (1100IU/g), the 1-alpha-tocopherol, and then at 65 ℃ with 500g (1.7 * 10 6IU/g) Retinol Palmitate adds.
B) preparation of emulsion
The gum arabic of 2kg and the sucrose of 2kg are dissolved in the 9kg distilled water that places the emulsification container under 65 ℃.Stir after 30 minutes, 500g solution is transferred in the 1L reactor, with the 45g vitamin K 1Homogeneous together, remaining protecting colloid solution be mixed together and about 2 hours of homogeneous by the vitamin mixtures that a) obtains.Above-mentioned two kinds of emulsions are slowly mixed in an independent emulsification container, and dilute with water is about 100cp until viscosity, and uses starch encapsulated, at the spray tower inner drying.
Obtained to have the faint yellow vitamin dry powder of following vitamin content:
Retinol Palmitate: 72000IU/g
Vitamin D 3: 3340IU/g
Vitamin K 1: 0.44%
D, 1-alpha-tocopherol: 4.17%
Vitamin D 3Content reduce to about 50% original consumption
Embodiment 3
A) preparation of vitamin mixtures
1.7g (4 * 10 7IU/g) vitamin D 3By under 65 ℃ of stirrings, being dissolved in 500g (1.7 * 10 6IU/g) Retinol Palmitate, and then with the d of 500g (1100IU/g), the 1-alpha-tocopherol adds.
B) preparation of emulsion
The gum arabic of 2kg and the sucrose of 2kg are dissolved in the 9kg distilled water that places the emulsification container under 65 ℃.Stir after 30 minutes, this solution of 500g is transferred in the 1L reactor, with the vitamin K of 45g 1Homogeneous together.Remaining protecting colloid solution be mixed together and about 2 hours of homogeneous by the vitamin mixtures that a) obtains.Above-mentioned two kinds of emulsions are slowly mixed in an independent emulsification container, are diluted with water to the about 100cp of viscosity, and use starch encapsulated, at the spray tower inner drying.
This faint yellow vitamin dry powder has following vitamin content:
Retinol Palmitate: 103000IU/g
Vitamin D 3: 7540IU/g
Vitamin K 1: 0.49%
D, 1-alpha-tocopherol: 4.68%
Embodiment 4
A) preparation of vitamin mixtures
1.7g (4 * 10 7IU/g) vitamin D 3By under 65 ℃ of stirrings, being dissolved in the fractionated coconut oil of 65g, and then under 65 ℃ with 500g (1.7 * 10 6IU/g) d of Retinol Palmitate and 500g (1100IU/g), the mixture of 1-alpha-tocopherol adds.
B) preparation of emulsion
The gum arabic of 2kg and the sucrose of 2kg are dissolved in the 9kg distilled water that places the emulsification container under 65 ℃.Stir after 30 minutes, 500g solution is transferred in the 1L reactor, with the 45g vitamin K 1Homogeneous together.Remaining protecting colloid solution be mixed together and about 2 hours of homogeneous by the vitamin mixtures that a) obtains.Above-mentioned two kinds of emulsions are slowly mixed in an independent emulsification container, and dilute with water is until the about 100cp of viscosity, and use starch encapsulated, at the spray tower inner drying.
This faint yellow vitamin dry powder has following vitamin content:
Retinol Palmitate: 71600IU/g
Vitamin D 3: 5850IU/g
Vitamin K 1: 0.36%
D, 1-alpha-tocopherol: 3.96%
Embodiment 5
A) preparation of vitamin mixtures:
1.2g (4 * 10 7IU/g) vitamin D 3By under 65 ℃ of stirrings, being dissolved in 350g (1.7 * 10 6IU/g) Retinol Palmitate, and then add the d of 350g (1100IU/g), the 1-alpha-tocopherol.
B) preparation of emulsion
1.4kg the starch of usefulness sodium octenyl succinate modification and the sucrose of the 1.4kg distilled water that under 65 ℃, is dissolved in the 6.3kg that places the emulsification container.Stir after 30 minutes, 500g solution is transferred in the 1L reactor, with the vitamin K of 33g 1Homogeneous together.Remaining protecting colloid solution be mixed together and about 2 hours of homogeneous by the vitamin mixtures that a) obtains.Above-mentioned two kinds of emulsions are slowly mixed in an independent emulsification container, and dilute with water is until the about 100cp of viscosity, and use starch encapsulated, at the spray tower inner drying.
This faint yellow vitamin dry powder has following vitamin content:
Retinol Palmitate: 85300IU/g
Vitamin D 3: 7080IU/g
Vitamin K 1: 0.44%
D, 1-alpha-tocopherol: 4.78%
Embodiment 6
A) preparation of vitamin mixtures
2.6g (4 * 10 7IU/g) vitamin D 3By under 65 ℃ of stirrings, being dissolved in 750g (1.7 * 10 6IU/g) in the preheating Retinol Palmitate, and then at 65 ℃ of d with 750g (1100IU/g), the 1-alpha-tocopherol adds.
B) preparation of emulsion
The Sodium Caseinate of 2kg and the sucrose of 4kg are dissolved in the 7kg distilled water that places the emulsification container under 65 ℃.Stir after 30 minutes, 500g solution is transferred in the 1L reactor, with the vitamin K of 68g 1Homogeneous together.Remaining protecting colloid solution be mixed together and about 2 hours of homogeneous by the vitamin mixtures that a) obtains.Above-mentioned two kinds of emulsions are slowly mixed in an independent emulsification container, are diluted with water to the about 100cp of viscosity, and use starch encapsulated, at the spray tower inner drying.
This faint yellow vitamin dry powder has following vitamin content:
Retinol Palmitate: 86500IU/g
Vitamin D 3: 6950IU/g
Vitamin K 1: 0.47%
D, 1-alpha-tocopherol: 4.8%
Embodiment 7
The preparation of vitamin mixtures
1.7g (4.0 * 10 7IU/g) vitamin D 3By under 65 ℃ of stirrings, being dissolved in the d of 500g (1100IU/g), the 1-alpha-tocopherol, and then at 65 ℃ with 500g (1.7 * 10 6IU/g) Retinol Palmitate adds.This mixture then is cooled to 4 ℃, and preserves for 2 weeks under this temperature.After 4 days and 10 days, measure the content of vitamin in the mixture.
4 days:
The calculated value measured value
Retinol Palmitate 850000IU/g 848000IU/g
Vitamin D 366000IU/g 33500IU/g
D, 1-alpha-tocopherol 49.9% 50.0%
10 days:
The calculated value measured value
Vitamin D 3: 66000IU/g 33500IU/g
Embodiment 8
The vitamin D of table 1 is listed in use 3(4 * 10 7IU/g) or be dissolved in the vitamin D of fractionated coconut oil 3Solution and the d of multiple consumption, 1-alpha-tocopherol (1100 IU/g) mixes under 65 ℃ of stirrings.After preparation finishes, analyze the vitamin D content of this blend sample at once.In 65 ℃ of storages 24 hours, second half preserved 24 hours down at 5 ℃ remaining half vitamin mixtures in all cases.These two halves then carry out vitamin D 3Determination on content.
Table 1
Embodiment Vitamin D [mg] Coconut oil [g] Vitamin E [g] Vitamin D content (5min, 65 ℃) [%of th.] Vitamin D content (24h, 65 ℃) [%of th.] Vitamin D content (24h, 5 ℃) [%of th.]
????1 ????52.9 ??14.90 ????69 ????2 ????61
????2 ????52.3 ??3.68 ??10.90 ????89 ????50 ????90
????3 ????51.1 ??7.28 ??7.30 ????93 ????87 ????93
????4 ????54.9 ?10.99 ??3.68 ????94 ????86 ????90

Claims (20)

1, a kind of method that is used to prepare a kind of stable vitamin emulsion or stable vitamin dry powder, comprising emulsification respectively in water in each case:
A) vitamin K and
B) mixture of the mixture of vitamin D, vitamin E and vitamin A or inert oil or vitamin A and inert oil, its acquisition be by
b 1) vitamin D is dissolved in inert oil and/or vitamin A, mix with vitamin E, or
b 2) vitamin D is added the mixture of vitamin E and vitamin A and/or inert oil,
To a) and b) composition each exist at following material and to carry out emulsification under the situation
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
Then mix each emulsion, and suitable words under the situation that coating exists dry this mixture to prepare stable vitamin dry powder.
2, a kind of method that is used to prepare stable vitamin emulsion or stable vitamin dry powder is comprising the mixture of the following material of emulsification in water
A) mixture of vitamin D, vitamin E and vitamin K and vitamin A or inert oil or vitamin A and inert oil, its acquisition be by:
a 1) vitamin D is dissolved in inert oil and/or vitamin A, and mix with vitamin E and vitamin K, or
a 2) vitamin D is added in the mixture of vitamin E and vitamin K and vitamin A and/or inert oil,
Emulsification is to exist under the situation at following material to carry out:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words
And suitable words are under the coating existence condition, and dry this emulsion is to prepare stable vitamin dry powder.
3, according to the method for claim 1 and 2, wherein vitamin mixtures contains vitamin A and/or the inert oil of 5-90%wt, the vitamin E of 5-90%wt, the vitamin D of 0.01-1%wt and the vitamin K of 0.1-10%wt are 100% for the percent by weight data sum of each component.
4, according to any described method of claim among the claim 1-3, wherein vitamin mixtures contains vitamin A and/or the inert oil of 25-70%wt, the vitamin E of 30-70%wt, the vitamin D of 0.05-0.4%wt and the vitamin K of 2-8%wt are 100% for the percent by weight data sum of each component.
5, a kind of method that is used to prepare stable vitamin emulsion or stable vitamin dry powder, comprising in water, distinguishing emulsification in all cases:
A) vitamin K and
B) mixture of vitamin D and vitamin A,
To a) and b) composition each exist at following material and to carry out emulsification under the situation
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
Then mix each emulsion, suitable words are under the situation that coating exists, and dry this mixture is to prepare stable vitamin dry powder.
6, a kind of method that is used to prepare stable vitamin emulsion or stable vitamin dry powder, comprising emulsification in water:
A) vitamin A, vitamin K and vitamin D mixture are emulsified under the following material existence condition and carry out:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words
And suitable words are under the condition that coating exists, and dry this emulsion is to prepare stable vitamin dry powder.
7, according to claim 5 and 6 described methods, wherein vitamin mixtures contains the vitamin A of 70-98%wt, and the vitamin D of 0.01-1%wt and the vitamin K of 2-30%wt are 100% for the percent by weight data sum of above-mentioned each component.
8, a kind of method that is used to prepare stable vitamin emulsion or stable vitamin dry powder, comprising emulsification in all cases respectively in water:
A) vitamin K and
B) mixture of vitamin A and vitamin E,
To a) and b) composition each exist at following material and to carry out emulsification under the situation:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words
Then mix each emulsion, suitable words are under the condition that coating exists, and dry this mixture is to prepare stable vitamin dry powder.
9, a kind of method that is used to prepare stable vitamin emulsion or stable vitamin dry powder, comprising emulsification in water:
A) mixture of vitamin A, vitamin E and vitamin K is emulsified under the following material existence condition and carries out:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words,
And suitable words are under the coating existence condition, and dry this emulsion is to prepare stable vitamin dry powder.
10, according to Claim 8 with 9 described methods, wherein vitamin mixtures contains the vitamin A of 5-90%wt, the vitamin E of 5-90%wt and the vitamin K of 0.1-10%wt are 100% for the percent by weight data sum of above-mentioned various components.
11, a kind of method that is used to prepare stable vitamin emulsion or stable vitamin dry powder is carried out emulsification comprising the mixture to following material in water,
A) mixture of vitamin D, vitamin E and vitamin A or inert oil or vitamin A and inert oil, its acquisition be by:
a 1) vitamin D is dissolved in inert oil and/or vitamin A, and mix with vitamin E, or
a 2) vitamin D is added in the mixture of vitamin E and vitamin A and/or inert oil,
Be emulsified under the following material existence condition and carry out:
C) one or more protecting colloids,
D) suitable one or more sugar of words and/or sugar alcohol and
E) suitable other additive of words
And suitable words are under the coating existence condition, and dry this emulsion is to prepare stable vitamin dry powder.
12, method according to claim 11, wherein vitamin mixtures contains vitamin A and/or the inert oil of 5-90%wt, the vitamin E of 5-90%wt and the vitamin D of 0.01-1%wt are 100% for the percent by weight data sum of above-mentioned each component.
13, according to any described method of claim of claim 1 to 12; wherein gelatin, gum arabic, vegetable protein and/or modified starch are as protecting colloid; sucrose, lactose and/or maltodextrin are as sugar, and cornstarch and/or rice starch are as coating.
14, according to any described method of claim of claim 1 to 13, wherein term " vitamin A, D, E and/or K " also comprises their derivative and/or its mixture.
15, a kind of stable vitamin emulsion or stable vitamin dry powder, it can obtain by claim 1 or 2 described methods.
16, a kind of stable vitamin emulsion or stable vitamin dry powder, it can obtain by claim 5 or 6 described methods.
17, a kind of stable vitamin emulsion or stable vitamin dry powder, it can obtain by claim 8 or 9 described methods.
18, a kind of stable vitamin emulsion or stable vitamin dry powder, it can obtain by the described method of claim 11.
19, according to the described stable vitamin emulsion of claim 15 to 18 and/or the purposes of vitamin dry powder, it is used as the additive of food, medicine and/or animal feed.
20, food, medicine and/or animal feed, it comprises according to stable vitamin emulsion in any claim of claim 15 to 18 and/or stable vitamin dry powder.
CN97122804A 1996-10-14 1997-10-14 Stable emulsions and dry powders of mixtures of fat-soluble vitamins, their preparation and use Pending CN1179913A (en)

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CN97122804A CN1179913A (en) 1996-10-14 1997-10-14 Stable emulsions and dry powders of mixtures of fat-soluble vitamins, their preparation and use

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100574639C (en) * 2002-04-11 2009-12-30 协和发酵生化株式会社 Contain the liquid diet product of liposoluble vitamin and the stabilization method of liposoluble vitamin
CN101297680B (en) * 2008-04-25 2010-11-03 天津生机集团股份有限公司 Composite vitamin emulsion and preparation thereof
CN101606939B (en) * 2009-07-27 2010-12-01 徐新盛 Fat-soluble vitamin freeze-dried powder needle and preparation method thereof
CN101327202B (en) * 2006-06-23 2011-05-11 杭州平和安康医药科技有限公司 Vitamin K1 lyophilized powder for injection and preparation method
CN102939077A (en) * 2010-06-03 2013-02-20 莱迪杜德制药公司 Nanoemulsion composition containing vitamin k
CN103315957A (en) * 2013-06-27 2013-09-25 海南卫康制药(潜山)有限公司 Vitamin K1 lyophilized oral emulsion and preparation method thereof
CN105851762A (en) * 2016-04-15 2016-08-17 济南银中容和堂药业有限公司 Solid vitamin health drink

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100574639C (en) * 2002-04-11 2009-12-30 协和发酵生化株式会社 Contain the liquid diet product of liposoluble vitamin and the stabilization method of liposoluble vitamin
CN101327202B (en) * 2006-06-23 2011-05-11 杭州平和安康医药科技有限公司 Vitamin K1 lyophilized powder for injection and preparation method
CN101297680B (en) * 2008-04-25 2010-11-03 天津生机集团股份有限公司 Composite vitamin emulsion and preparation thereof
CN101606939B (en) * 2009-07-27 2010-12-01 徐新盛 Fat-soluble vitamin freeze-dried powder needle and preparation method thereof
CN102939077A (en) * 2010-06-03 2013-02-20 莱迪杜德制药公司 Nanoemulsion composition containing vitamin k
CN102939077B (en) * 2010-06-03 2016-04-06 莱迪杜德制药公司 Nano-emulsion composition containing vitamin K
CN103315957A (en) * 2013-06-27 2013-09-25 海南卫康制药(潜山)有限公司 Vitamin K1 lyophilized oral emulsion and preparation method thereof
CN105851762A (en) * 2016-04-15 2016-08-17 济南银中容和堂药业有限公司 Solid vitamin health drink

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