WO2011152657A3 - Acetyl-l-carnitine malate, process for preparing the same, and pharmaceutical composition comprising the same - Google Patents

Acetyl-l-carnitine malate, process for preparing the same, and pharmaceutical composition comprising the same Download PDF

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Publication number
WO2011152657A3
WO2011152657A3 PCT/KR2011/004002 KR2011004002W WO2011152657A3 WO 2011152657 A3 WO2011152657 A3 WO 2011152657A3 KR 2011004002 W KR2011004002 W KR 2011004002W WO 2011152657 A3 WO2011152657 A3 WO 2011152657A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
acetyl
preparing
pharmaceutical composition
carnitine malate
Prior art date
Application number
PCT/KR2011/004002
Other languages
French (fr)
Other versions
WO2011152657A2 (en
Inventor
Kyoung Soo Kim
Young Jun Park
Hyun-Nam Song
Dong Youn Kim
Joon Woo Kim
Kyoung-Suk Cho
Keewon Yu
Hyuk Jin Kwon
Original Assignee
Celltrion Chemical Research Institute
Celltrion Pharm, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltrion Chemical Research Institute, Celltrion Pharm, Inc. filed Critical Celltrion Chemical Research Institute
Publication of WO2011152657A2 publication Critical patent/WO2011152657A2/en
Publication of WO2011152657A3 publication Critical patent/WO2011152657A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups

Abstract

The present invention relates to acetyl-L-carnitine malate, a process for preparing the same, and a pharmaceutical composition comprising the same. The acetyl-L-carnitine malate of the present invention has good stability, solubility, and non-hygroscopicity to be effectively used for preparing a pharmaceutical composition.
PCT/KR2011/004002 2010-06-01 2011-06-01 Acetyl-l-carnitine malate, process for preparing the same, and pharmaceutical composition comprising the same WO2011152657A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0051791 2010-06-01
KR1020100051791A KR101168657B1 (en) 2010-06-01 2010-06-01 Acetyl-L-carnitine malate, process for preparing the same, and pharmaceutical composition comprising the same

Publications (2)

Publication Number Publication Date
WO2011152657A2 WO2011152657A2 (en) 2011-12-08
WO2011152657A3 true WO2011152657A3 (en) 2012-04-26

Family

ID=45067189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/004002 WO2011152657A2 (en) 2010-06-01 2011-06-01 Acetyl-l-carnitine malate, process for preparing the same, and pharmaceutical composition comprising the same

Country Status (2)

Country Link
KR (1) KR101168657B1 (en)
WO (1) WO2011152657A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204782B (en) * 2013-04-25 2014-12-31 四川海思科制药有限公司 Crystal form of chloracetyl-levocarnitine compound
CN104177271B (en) * 2014-06-23 2016-08-17 海南好康舒药业有限公司 A kind of preparation method of ALC
CN105732407B (en) * 2016-02-02 2017-12-01 广东隆赋药业股份有限公司 The synthetic method of acetyl levocarnitine inner salt

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068075A2 (en) * 2000-03-10 2001-09-20 Hill's Pet Nutrition Method for increasing intestinal absorption of fat soluble vitamins in post-menopausal women and lower animals
US20080249168A1 (en) * 2007-04-06 2008-10-09 Shuhua Gu Pharmaceutical composition for gout

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068075A2 (en) * 2000-03-10 2001-09-20 Hill's Pet Nutrition Method for increasing intestinal absorption of fat soluble vitamins in post-menopausal women and lower animals
US20080249168A1 (en) * 2007-04-06 2008-10-09 Shuhua Gu Pharmaceutical composition for gout

Also Published As

Publication number Publication date
WO2011152657A2 (en) 2011-12-08
KR20110132010A (en) 2011-12-07
KR101168657B1 (en) 2012-07-25

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