WO2011147767A1 - Tamarind seed polysaccharide for use in the treatment of microbial infections - Google Patents

Tamarind seed polysaccharide for use in the treatment of microbial infections Download PDF

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Publication number
WO2011147767A1
WO2011147767A1 PCT/EP2011/058332 EP2011058332W WO2011147767A1 WO 2011147767 A1 WO2011147767 A1 WO 2011147767A1 EP 2011058332 W EP2011058332 W EP 2011058332W WO 2011147767 A1 WO2011147767 A1 WO 2011147767A1
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WIPO (PCT)
Prior art keywords
tamarind seed
seed polysaccharide
treatment
tsp
antimicrobial
Prior art date
Application number
PCT/EP2011/058332
Other languages
French (fr)
Inventor
Andrea Giori
Giacomo Mombelli
Stefano Togni
Original Assignee
Indena S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SI201130725T priority Critical patent/SI2575971T1/en
Priority to EP11724579.5A priority patent/EP2575971B1/en
Application filed by Indena S.P.A. filed Critical Indena S.P.A.
Priority to MX2012013606A priority patent/MX341220B/en
Priority to RU2012149863/15A priority patent/RU2571063C2/en
Priority to US13/699,406 priority patent/US10206943B2/en
Priority to DK11724579.5T priority patent/DK2575971T3/en
Priority to BR112012029739A priority patent/BR112012029739A2/en
Priority to AU2011257387A priority patent/AU2011257387B2/en
Priority to CN201180025355.0A priority patent/CN103025386B/en
Priority to ES11724579.5T priority patent/ES2560953T3/en
Priority to CA2800382A priority patent/CA2800382C/en
Priority to KR1020127030677A priority patent/KR101878450B1/en
Priority to SG2012085791A priority patent/SG185693A1/en
Priority to JP2013511628A priority patent/JP2013526594A/en
Priority to PL11724579T priority patent/PL2575971T3/en
Publication of WO2011147767A1 publication Critical patent/WO2011147767A1/en
Priority to IL223176A priority patent/IL223176A/en
Priority to HK13110943.2A priority patent/HK1183454A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
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    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Abstract

The present invention relates to the use as an antimicrobial of tamarind seed polysaccharide (TSP) and to antimicrobial compositions which contain it as active ingredient. Antimicrobial compositions containing TSP are particularly useful for topical administration in the treatment and/or prevention of microbial infections of the skin and mucosa.

Description

TAMARIND SEED POLYSACCHARIDE FOR USE IN THE TREATMENT OF
MICROBIAL INFECTIONS
Technical field of the invention
The present invention relates to the use of tamarind seed polysaccharide as an antimicrobial and to antimicrobial compositions which contain it as active ingredient.
Background of the invention
Tamarind seed polysaccharide (TSP) is a natural polysaccharide polymer obtained from the seeds of Tamarindus indica, an evergreen plant which can reach a height of 15 metres and produces fruit in the form of pods. It is very common in India, Africa and throughout the Far East, where it is mainly grown as a food. The fruit contains large seeds with a high percentage of polysaccharides, which have the function of accumulating and preserving vital energy-giving substances. Tamarind seeds, which were originally considered as waste products, have subsequently found different applications after grinding to obtain a farinaceous product (known as tamarind gum or tamarind nut powder). The most important of these applications is in the textile industry and the paper industry, where tamarind gum is used as a sizing and gluing agent, and in the food industry where, like other polysaccharides, it is used as a thickener, gelling agent, stabiliser and binder in various products. Raw tamarind gum is a commercially available product containing from 65% to 73% by weight of polysaccharide, from 15% to 23% by weight of protein material, from 3% to 8% by weight of fats and oils, and from 2% to 4% by weight of ash, together with smaller amounts of raw fibre, tannins and other impurities.
More recently, TSP has also been used in the pharmaceutical field as active ingredient in tears substitutes (WO2009/044423), as a carrier for slow- release ophthalmic medicaments for topical administration (WO97/28787) and, more generally, as an excipient due to its mucoadhesive characteristics (WO2006/131262).
Summary of the invention
The present invention refers to the use of tamarind seed polysaccharide in prevention and/or treatment of microbial infections.
The invention also relates to an antimicrobial pharmaceutical and/or dermocosmetic composition comprising tamarind seed polysaccharide as active ingredient mixed with one or more acceptable excipients.
Furthermore, the invention concerns a method of preventing or treating a patient having a microbial infection comprising administering a therapeutically effective amount of Tamarind seed polysaccharide.
Detailed description of the invention
We have now found that tamarind seed polysaccharide (hereinafter called TSP) has antimicrobial properties, especially when administered topically.
Object of the present invention is therefore the use of TSP as an antimicrobial and, in particular, the use of TSP as an antimicrobial for topical administration.
A further object of the present invention is an antimicrobial pharmaceutical and/or dermocosmetic composition comprising TSP mixed with one or more acceptable excipients and, more particularly, an antimicrobial pharmaceutical and/or dermocosmetic composition for topical administration comprising TSP mixed with one or more acceptable excipients.
TSP can be used, as an antimicrobial according to the present invention, alone or in combination with other active ingredients.
A further object of the present invention is therefore the use of TSP as an antimicrobial in combination with one or more active ingredients and, more particularly, the use of TSP as an antimicrobial for topical administration in combination with one or more active ingredients.
Antimicrobial pharmaceutical and/or dermocosmetic compositions and, more particularly, antimicrobial pharmaceutical and/or dermocosmetic compositions for topical administration, comprising TSP in combination with one or more active ingredients mixed with one or more acceptable excipients, also form the object of the present invention.
According to the present invention, "TSP" means a polysaccharide- enriched fraction obtained from tamarind gum commercially available, for example from Dainippon Sumitomo Pharma Ltd. under the Glyloid® trademark or from Indena SpA under the Xilogel® trademark.
The active ingredients which can be used in combination with TSP are, for example, antimicrobial agents, anti-inflammatory agents, wound-healing agents.
The preferred antimicrobial agents are antibiotics such as clindamycin, erythromycin, benzylpenicillin, tetracycline, chloramphenicol, vancomycin and linezolid.
Anti-inflammatory agents include steroidal anti-inflammatory drugs, such as cortisone, and non-steroidal anti-inflammatory drugs, such as acetylsalicylic acid and ibuprofen.
Wound-healing agents may be of natural or synthetic origin.
Particularly preferred is the combination of TSP with other extracts of plant origin, especially extracts of plant origin which possess antimicrobial and/or anti-inflammatory and/or wound-healing properties.
The use of TSP in combination with other extracts of plant origin can have a synergic effect on antimicrobial activity.
Preferred examples of extracts of plant origin which may be used in combination with TSP are extracts of Helichrysum italicum, Echinacea spp., Aesculus hippo castanum and Zanthoxylum bungeanum. The extracts of Helichrysum italicum, Echinacea spp. and Aesculus hippocastanum are known individually for their antimicrobial action.
The active ingredients in Helichrysum italicum extract are contained in the aerial parts of the plant, which contains non-flavonoid prenylated polyphenols. The extracts of Helichrysum italicum are known and can be prepared by conventional methods.
The active ingredients of Echinacea spp. extract are contained in the aerial part of the plant, which contains echinacoside. The extracts of Echinacea spp. are known and can be prepared by conventional methods.
The active ingedients of Aesculus hippocastanum extract are contained in the seed and in the bark of the plant, which contains proanthocyanidin A2 (PA2).
The extracts of Aesculus hippocastanum are known and can be prepared by known methods.
The active ingredients in Zanthoxylum bungeanum extract are contained in the pericarp, which contains alkamides. The extracts of Zanthoxylum bungeanum are known and can be prepared by conventional methods.
For use as an antimicrobial according to the present invention, TSP is formulated in suitable pharmaceutical and/or dermocosmetic compositions, preferably in topical pharmaceutical and/or dermocosmetic compositions. The topical pharmaceutical and/or dermocosmetic compositions according to the invention comprise TSP mixed with one or more suitable excipients and may be, for example, in the form of cream, ointment, gel, gum, toothpaste, mouthwash or shampoo.
TSP may generally be used in quantities of between 0.1% and 5% by weight, preferably between 0.1% and 2% by weight, and even more preferably between 0.2% and 1% by weight.
The other active ingredients optionally present in combination with TSP are used in suitable effective quantities. In the case of other extracts of plant origin used in combination with TSP, their quantity is generally between 0.1 % and 5% by weight, preferably between 0.1 % and 2% by weight, and even more preferably between 0.2% and 1% by weight.
Examples of suitable excipients that may be used in the compositions according to the invention are solvents, diluents, gliding agents, preservatives, gums, sweeteners, coating agents, binders, disintegrating agents, lubricants, suspending agents, dispersing agents, colorants, flavouring agents, non-stick agents, surfactants, plasticisers, emulsifiers, chelating agents and emollients.
The solvent preferably used is water, but alcohols or other organic solvents may also be used, possibly mixed with water.
The choice of excipients is part of the normal knowledge of one skilled in the art, and will mainly depend on the pharmaceutical and/or dermocosmetic form chosen.
For example, a cream can be prepared by incorporating TSP in a topical carrier consisting of liquid paraffin, dispersed in an aqueous medium by means of lubricants. An ointment can be prepared by mixing TSP with a topical carrier such as mineral oil or wax. A gel can be prepared by mixing TSP with a topical carrier containing a gelling agent.
The pharmaceutical and/or dermocosmetic composition according to the invention may also be a, woven or non-woven, material coated and/or impregnated with a mixture of TSP with a suitable carrier or a matrix in which TSP is dispersed so that it comes into contact with the skin for transdermal administration. Specific examples are sticking plasters, gauze, towelettes, etc.
The choice of type of pharmaceutical and/or dermocosmetic form will depend mainly on the area to be treated and is part of the normal knowledge of one skilled in the art. For example, a gum or mouthwash may be more suitable to treat the oral cavity, whereas a cream, ointment, lotion or towelettes may be suitable for the skin of the face.
The treatment with TSP according to the present invention is effective in stimulating the antimicrobial response, especially when administered topically to the skin and to the mucosa.
According to the invention, the term "microbial infection" refers to harmful colonisation of a host organism by one or more microbial species. The host organism can be human or animal, preferably human. The microbe that causes the infection can be a bacterium, a yeast, a virus or a fungus. TSP is particularly indicated for the treatment and/or prevention of bacterial infections.
The compositions according to the invention are therefore useful to treat any disorder of the skin or mucosa caused by the presence of one or more microbes. Contact between the skin or mucosa and a composition according to the invention reduces the bioburden, namely the number of microbes, in the contact area.
The term "skin" is used according to the present in its conventional meaning, namely an external organ including the epithelial tissue. The term "mucosa" is also used with its usual meaning, which relates to all the mucosal barriers in the body, such as the gastrointestinal, pulmonary, sublingual, buccal, rectal, vaginal, nasal, urethral and ocular barriers.
The compositions according to the invention are preferably applied by topical administration directly to the area of the skin or mucosa which presents, or is assumed to present, a microbial infection or other disorders caused by the presence of microbes. The infection often originates in a part of the skin or mucosa which presents a lesion, such as a wound, laceration or burn. In such case, the composition according to the invention can be applied directly to the lesion and/or the surrounding area.
Numerous disorders of the skin and mucosa caused by microbes are known. For example, one disorder of the skin or mucosa which can be effectively treated or prevented by applying a composition according to the invention is the ulcer, i.e. an open wound on the skin or mucosa which is usually caused initially by an abrasion followed by a microbial infection.
Ulcers at every stage (from 1 to 6 in the Merck Manual's classification system) can be treated with the compositions according to the invention. Ulcers are most frequent in patients with diabetes (diabetic ulcers, especially diabetic foot ulcers).
Ulcerations of the oral mucosa can also be treated with the compositions according to the invention.
In particular, TSP can be used for the topical treatment of mucositis and stomatitis.
The terms mucositis and stomatitis are often used interchangeably, although the two disorders can present some differences.
Mucositis is a toxic inflammatory reaction which affects the gastrointestinal tract and can be caused by exposure to chemotherapy agents or ionising radiation. Mucositis is generally manifested as an erythematous lesion similar to a burn or as a random ulcerative lesion from focal to diffuse.
Stomatitis is an inflammatory reaction that affects the oral mucosa, with or without ulceration, which can be caused or intensified by pharmacological treatments, especially chemotherapy, or by radiotherapy.
The degree of stomatitis can range from mild to severe and the patient with severe stomatitis may be unable to eat or drink or take medicinal products by mouth.
Many women suffer from mouth ulcers at certain stages of the menstrual cycle and at the same time present the same type of ulcers in the genital tract, especially the vulva and vagina. They are sometimes very severe and can cause urine retention and require strong analgesics and sedatives. The most serious is known as Behcet's Syndrome.
According to the invention, the more general term of mucositis will also be used to indicate stomatitis.
Erythematous mucositis may appear as early as three days after exposure to chemotherapy or radiotherapy, but more commonly appears after 5-7 days. The progress to ulcerative mucositis takes place within 7 days of the start of chemotherapy and can sometimes become so severe as to require discontinuance of the pharmacological treatment. Mucositis can involve the mouth and the oropharyngeal tract as well as the gastrointestinal tract from mouth to anus. In the present context, unless otherwise specified, reference is made to mucositis which relates to the more easily accessible regions such as the mouth, pharynx, oesophagus and rectum.
As a high percentage (30-40%) of patients who receive chemotherapy develop mucositis of varying degrees of severity, there is a particular need for an effective, convenient treatment. No effective treatment is currently available, and attempts to solve the problem involve the use of analgesics, antiseptics and oral hygiene measures or attenuation of the symptoms.
Moreover, the problem is not limited to cancer patients, because mucositis frequently also occurs in patients with HIV, especially when associated with Kaposi's sarcoma, in patients suffering from non-Hodgkin's lymphoma, in debilitated elderly patients and in patients receiving treatments with B Ms (Biological Response Modifiers) such as interleukin-2, interferons, lymphocytes activated by lymphokines and the like.
The following examples are provided to further illustrate the present invention. Examples
Example 1 - Cream for topical use
TSP (tamarind seed polysaccharide) 0.200% (w/w) Aesculus hippocastanum extract 0.200% (w/w) Helichrysum italicum extract 0.200% (w/w) Water 75.150% (w/w)
Montanov 202 5.000% (w/w) Lanol 99 10.000% (w/w) Sepilift DPHP 1.000% (w/w) Monoi Butter 2.000% (w/w) Sepifeel One 1.000% (w/w) Aquaxyl 3.000% (w/w) Panthenol 1.000% (w/w) Tocopheryl acetate 0.600% (w/w) Sepicide HB 0.300% (w/w) Perfume 0.250% (w/w)
Sodium hydroxide (30% sol.) 0.100% (w/w) Total 100.000% (w/w)
Example 2 - Oral paste
TSP (tamarind seed polysaccharide) 0.300% (w/w)
Aesculus hippocastanum extract 0.200% (w/w)
Zanthoxylum bungeanum extract 0.100% (w/w)
Sorbitol 50.000% (w/w)
Distilled water 35.040% (w/w)
Hydrated silica 8.000% (w/w)
Carboxymethylcellulose 5.000% (w/w)
Potassium sorbate 0.300% (w/w)
Sodium benzoate 0.300% (w/w)
PEG-40 hydrogenated castor oil 0.160% (w/w)
Sodium saccharine 0.100% (w/w)
Flavouring 0.500% (w/w)
Total 100.000% (w/w) Example 3 - Vaginal cream
TSP (tamarind seed polysaccharide) 0.200% (w/w)
Aesculus hippo castanum extract 0.200% (w/w)
Distilled water 73.300% (w/w)
Liquid paraffin 15.000% (w/w)
Cetearyl alcohol - PEG-20 stearate 9.000% (w/w)
Dimethicone 1.000% (w/w)
Phenoxyethanol 0.500% (w/w)
Imidazolidinyl urea 0.300% (w/w)
Propylparaben 0.150% (w/w)
Methylparaben 0.150% (w/w)
Sodium EDTA 0.100% (w/w)
Lactic acid 0.100% (w/w)
Total 100.000% (w/w)
Example 4 - Beta defensin expression in NHEK
Human keratinocytes were cultured in Dulbecco's Modified Eagle Medium with 10% FBS (fetal bovine serum) and 10 ml/L penicillin/streptomycin. NHEK (normal human epidermal keratinocyte) primary human keratinocytes were cultured in KGM (Keratinocyte Growth Medium) in a serum-free environment. Cells were cultured in medium alone (negative reference) or in medium added with LPS (lipopolysaccharides, positive reference) from Escherichia coli (5 mcg/ml).
Different standardized botanical extracts (at 0.2% concentration in the LPS free medium) either alone or in combination with Tamarind Seed Polysaccharide (at 0.2% concentration in the LPS free medium) were diluted in the LPS free medium with cultured keratynocites in Petri dishes. The details are reported in Table 1. Table 1
Products Concentration
Negative ref. (control) -
Positive ref. (LPS) 5 mcg/ml
Tamarind Seed Polysaccharide (TSP) 0.2%
Helichrysum italicum extract (HIE) 0.2%
HIE + TSP 0.2% + 0.2%
Aesculus hyppocastanum extract (AHE) 0.2%
AHE + TSP 0.2% + 0.2%
Echinacea extract (EE) 0.2%
EE + TSP 0.2% + 0.2%
Zanthoxylum alatum (ZA) 0.2%
ZA + TSP 0.2% + 0.2%
The overall expression of DEFB2 (β-defensin 2) was quantified after 18 hours of incubation in NHEK cell supernatants using an enzyme immunoassay kit (ELISA). Results are reported in Table 2.
Figure imgf000012_0001
*p < 0.001 vs. control

Claims

I . Tamarind seed polysaccharide for use in prevention and/or treatment of microbial infections.
2. Tamarind seed polysaccharide according to claim 1 , wherein the infection is caused by a bacterium, a yeast, a virus or a fungus.
3. Tamarind seed polysaccharide according to claim 2, wherein the infection is a bacterial infection.
4. Tamarind seed polysaccharide according to claims 1-3, for use in prevention and/or treatment of microbial infections of skin or mucosa.
5. Tamarind seed polysaccharide according to claims 1-4, for topical administration.
6. Tamarind seed polysaccharide according to claims 1-5, for use in treatment of mucositis and stomatitis.
7. An antimicrobial pharmaceutical and/or dermocosmetic composition containing tamarind seed polysaccharide as active ingredient mixed with one or more acceptable excipients.
8. A composition according to claim 7, for topical administration.
9. A composition according to claim 7 or 8, in the form of cream, ointment, gel, gum, toothpaste, mouthwash or shampoo.
10. A composition according to claims 7-9, comprising at least a further active ingredient selected from the group consisting of antimicrobial agents, anti- inflammatory agents and wound-healing agents.
I I . A composition according to claims 7-10, further comprising an extract of Helichrysum italicum, Echinacea spp., Aesculus hippocastanum,
Zanthoxylum bungeanum or mixtures thereof.
12. A composition according to claims 7-1 1 , wherein the tamarind seed polysaccharide quantity ranges from 0.1 % to 5% by weight. medicament for prevention and/or treatment of microbial infections.
14. A method of preventing and/or treating a patient having a microbial infection comprising administering a therapeutically effective amount of Tamarind seed polysaccharide.
PCT/EP2011/058332 2010-05-24 2011-05-23 Tamarind seed polysaccharide for use in the treatment of microbial infections WO2011147767A1 (en)

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SG2012085791A SG185693A1 (en) 2010-05-24 2011-05-23 Tamarind seed polysaccharide for use in the treatment of microbial infections
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MX2012013606A MX341220B (en) 2010-05-24 2011-05-23 Tamarind seed polysaccharide for use in the treatment of microbial infections.
RU2012149863/15A RU2571063C2 (en) 2010-05-24 2011-05-23 Polysaccharide of tamarind seed for application in treatment of microbial infections
US13/699,406 US10206943B2 (en) 2010-05-24 2011-05-23 Antimicrobial compositions
DK11724579.5T DK2575971T3 (en) 2010-05-24 2011-05-23 Combined plant extracts for use in the treatment of microbial infections
BR112012029739A BR112012029739A2 (en) 2010-05-24 2011-05-23 tamarind seed polysaccharide for use in the treatment of microbial infections
SI201130725T SI2575971T1 (en) 2010-05-24 2011-05-23 Combined plant extracts for use in the treatment of microbial infections
CN201180025355.0A CN103025386B (en) 2010-05-24 2011-05-23 Be used for the treatment of the tamarind seed polysaccharide of infected by microbes
CA2800382A CA2800382C (en) 2010-05-24 2011-05-23 Tamarind seed polysaccharide for use in the treatment of microbial infections
ES11724579.5T ES2560953T3 (en) 2010-05-24 2011-05-23 Combined plant extracts for use in the treatment of microbial infections
KR1020127030677A KR101878450B1 (en) 2010-05-24 2011-05-23 Tamarind seed polysaccharide for use in the treatment of microbial infections
EP11724579.5A EP2575971B1 (en) 2010-05-24 2011-05-23 Combined plant extracts for use in the treatment of microbial infections
JP2013511628A JP2013526594A (en) 2010-05-24 2011-05-23 Tamarind seed polysaccharide for use in the treatment of microbial infections
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ITMI20121917A1 (en) * 2012-11-09 2014-05-10 Velleja Res Srl COMPOSITIONS FOR VAGINAL USE INCLUDING POLYSACCHARIDES FROM TAMARINDO
WO2014072230A1 (en) * 2012-11-09 2014-05-15 Velleja Research S.R.L. Compositions for vaginal use containing tamarind polysaccharides
WO2015158771A1 (en) 2014-04-15 2015-10-22 Novintethical Pharma Sa Compositions based on xyloglucan and proteins for the treatment of intestinal disorders
EP3348273A1 (en) 2014-04-15 2018-07-18 Novintethical Pharma SA Compositions based on xyloglucan and proteins for the treatment of intestinal disorders
EP3103438A1 (en) 2015-06-11 2016-12-14 Novintethical Pharma SA Topical nasal compositions containing xyloglucans for use as decongestans
WO2022154772A1 (en) * 2021-01-12 2022-07-21 Almediko Saglik Urunleri Turizm Gida Sanayi Ve Ticaret Limited Sirketi Anti-viral agent used in upper respiratory tract viral infections and the pharmaceutical composition comprising the same

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