WO2011146977A1 - Délivrance de produits de soin capillaire - Google Patents

Délivrance de produits de soin capillaire Download PDF

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Publication number
WO2011146977A1
WO2011146977A1 PCT/AU2011/000618 AU2011000618W WO2011146977A1 WO 2011146977 A1 WO2011146977 A1 WO 2011146977A1 AU 2011000618 W AU2011000618 W AU 2011000618W WO 2011146977 A1 WO2011146977 A1 WO 2011146977A1
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WO
WIPO (PCT)
Prior art keywords
magnetic
pairs
hair
active agent
dipolar
Prior art date
Application number
PCT/AU2011/000618
Other languages
English (en)
Inventor
Jeffrey Edwards
Original Assignee
International Scientific Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2010902282A external-priority patent/AU2010902282A0/en
Application filed by International Scientific Pty Ltd filed Critical International Scientific Pty Ltd
Publication of WO2011146977A1 publication Critical patent/WO2011146977A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/06—Magnetotherapy using magnetic fields produced by permanent magnets
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D19/00—Devices for washing the hair or the scalp; Similar devices for colouring the hair
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D19/00—Devices for washing the hair or the scalp; Similar devices for colouring the hair
    • A45D19/16—Surface treatment of hair by steam, oil, or the like
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B15/00—Other brushes; Brushes with additional arrangements
    • A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
    • A46B15/0016—Arrangements for enhancing monitoring or controlling the brushing process with enhancing means
    • A46B15/0026—Arrangements for enhancing monitoring or controlling the brushing process with enhancing means with a magnetic means
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B2200/00—Brushes characterized by their functions, uses or applications
    • A46B2200/10—For human or animal care
    • A46B2200/104—Hair brush
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B2200/00—Brushes characterized by their functions, uses or applications
    • A46B2200/10—For human or animal care
    • A46B2200/1046—Brush used for applying cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body

Definitions

  • the present invention relates to a method and apparatus for enhanced delivery of substances (such as pharmaceuticals, nutraceuticals, biopharmaceuticals, cosmeceutical, biologically active substances, detergents, cleaners, bleaches, dyes, fragrances, conditioners or polishes) to the hair shaft, follicles or scalp by application of magnetic fields having distinctive, complex characteristics when such magnetic fields are stationary or in motion.
  • substances such as pharmaceuticals, nutraceuticals, biopharmaceuticals, cosmeceutical, biologically active substances, detergents, cleaners, bleaches, dyes, fragrances, conditioners or polishes
  • a diffusion enhancement technique which may be used for some biological surfaces is iontophoresis, in which an electrical energy gradient is used to accelerate the charged target active agent(s) across the skin or barrier.
  • iontophoresis is only suitable to specific active agents with certain ionic structures and can be injurious to certain biological barriers due to exchange ion degradation.
  • iontophoresis requires the use of intimate electrical contact and adhesive electrodes, which are not suitable for all target tissues or surfaces.
  • the present invention seeks to provide an improved delivery process for active agents that have a pharmaceutical, nutraceutical, biopharmaceutical, cosmeceutical, cosmetic, anti-biological (anti-bacterial, anti-viral, antifungal, anti- parasitic, insecticidal etc), detergent, cleaning, bleaching, dying, fragrancing, conditioning or polishing activity, in a manner which increases the directional penetration of these agents into the hair shaft, follicles or scalp.
  • a pharmaceutical, nutraceutical, biopharmaceutical, cosmeceutical, cosmetic, anti-biological (anti-bacterial, anti-viral, antifungal, anti- parasitic, insecticidal etc), detergent, cleaning, bleaching, dying, fragrancing, conditioning or polishing activity in a manner which increases the directional penetration of these agents into the hair shaft, follicles or scalp.
  • a method for the delivery of a hair care active agent(s) comprising the following step: (a) applying an active agent(s) between a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising one or more pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier.
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising one or more pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier.
  • a hair care active agent(s) comprising the following steps:
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising at least two sets of pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier and wherein the alignment of the first set of displaced dipolar magnetic elements is angularly offset relative to the alignment of the second set of displaced dipolar magnetic elements.
  • a hair care active agent(s) comprising the following steps:
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising at least two sets of pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier and wherein the alignment of the first set of displaced dipolar magnetic elements is angularly offset relative to the alignment of the second set of displaced dipolar magnetic elements
  • the method of the invention provides a means for driving the passage of active agent(s) across a biological barrier such as hair shaft, hair follicle, scalp etc into a subject (including a patient).
  • the method may be enhanced by the additional step of pairing the device with an alternate drug delivery system that operates either in conjunction with, or in parallel with, the device, to promote the passage of active agents through the biological barrier.
  • alternate drug delivery systems may include, for example, iontophoresis, drug-adhesive matrix, chemical penetration enhancers, micro-needles and sonophoresis.
  • the active agent(s) or a formulation including the active agent(s) is placed between the device and the subject (including a patient).
  • the device is preferably in the form of a brush.
  • the pairs of displaced dipolar magnetic elements may be incorporated into the brush in the form of: a sheet within the head of the brush (either immediately below the bristles, distal to the head of the brush from the bristles or forming one surface of a brush which does not have any bristles); the bristles of the brush themselves; panels of pairs of displaced dipolar magnetic elements which replace the traditional bristles; balls or domes which cap the ends of the bristles.
  • the device is formed as a pad comprising a sheet of pairs of displaced dipolar magnetic elements, a flexible or rigid backing panel and a handle.
  • Another form of the invention comprises a flexible membrane, such as a plastic film or woven piece of fabric, wherein the pairs of displaced dipolar magnetic elements are provided as a sheet adhered to one side of the membrane.
  • the membrane may comprise a flexible matrix within which the pairs of displaced dipolar magnetic elements are distributed.
  • the device may comprise a roller applicator or pen device wherein the pairs of displaced dipolar magnetic elements are located in the roller or pen nib.
  • the active agent may be applied to some or all of the device prior to applying (for example by rubbing or moving) the device to the biological barrier comprising the hair shaft, hair follicle or scalp/dermis, or the active agent may be applied directly to the biological barrier prior to use of the device.
  • Figure 1 is a representation of the nature of a pair of displaced dipolar magnetic elements and the magnetic return, and various combinations and orientations of dipole pairs. The arcs drawn between dipole pairs indicate magnetic return.
  • Figure 2 provides an example of a device according to the present invention which consists of two sets of pairs of displaced dipolar magnetic elements wherein the orientation of the second set is 90° to the orientation of the first set.
  • Figure 3 provides an example of a device according to the present invention which consists of two sets of pairs of displaced dipolar magnetic elements wherein the orientation of the second set is 45° to the orientation of the first set.
  • Figure 4 is an example of a brush comprising the device of the invention, wherein the pairs of displaced dipolar magnetic elements are provided in a sheetlike arrangement within the head of the brush (A).
  • Figure 5 is an example of a brush comprising the device of the present invention, wherein the pairs of displaced dipolar magnetic elements are in the form of a sheet (A), wherein the brush is moved over the hair/scalp surface without the need for bristles.
  • Figure 6 is an example of a brush comprising the device of the invention, wherein the pairs of displaced dipolar magnetic elements are laminated to a handle body such that they replace the role of bristles (A).
  • Figure 7 is an example of a brush comprising the device of the invention, wherein the traditional monofilament bristles of the brush have been replaced with
  • Figure 8 is an example of a brush comprising the device of the invention, wherein the bristles of the brush have been capped or terminated pairs of displaced dipolar magnetic elements in the form of balls or domes (A).
  • Figure 9 is an example of a pad comprising a sheet of pairs of displaced dipolar magnetic elements (A) which is further provided with a flexible or rigid backing panel and a handle.
  • Figure 10 is an example of a flexible membrane (A), such as a plastic film or woven piece of fabric, wherein the pairs of displaced dipolar magnetic elements are provided as a sheet adhered to one side of the membrane (B).
  • the membrane may comprise a flexible matrix within which the pairs of displaced dipolar magnetic elements are distributed.
  • Figure 1 is a graph of the change in luminosity and Red component of hair samples exposed to hair dye in either an Active (reciprocal movement of pairs of displaced dipolar magnetic elements) or Passive (no magnetic field) manner.
  • Figure 12 is a photograph of the dyed hair samples of Example 1 , with A5 being the hair exposed to dye in an Active manner, and P5 being hair exposed to dye in a Passive manner.
  • Figure 13 is a schematic of hair follicles after standard treatment and FIM application of hair removal cream, showing the mean hair lengths for each treatment.
  • Figure 14 is a schematic of a FIM applicator according to the present invention.
  • Figure 15 is a schematic of an example hair clamping assembly.
  • the invention described herein may include one or more range of values (eg. size, displacement and field strength etc).
  • a range of values will be understood to include all values within the range, including the values defining the range, and values adjacent to the range which lead to the same or substantially the same outcome as the values immediately adjacent to that value which defines the boundary to the range.
  • the inventor of the present invention has revealed that the penetration of an active agent into or onto the hair shaft, follicle or scalp can be enhanced by magnetic flux.
  • the inventors of the present invention also reveal that certain arrangements of magnetic flux may induce thermal noise and other forms of molecular disorder, which act against such magnetic enhanced penetration.
  • certain arrangements of magnetic elements as disclosed by the present invention, permit the coexistence of diamagnetic repulsion enhanced diffusion of active ingredients dielectric polarisation enhanced permeation changes. Therefore, in accordance with a first aspect of the present invention, there is provided a method for the delivery of a hair care active agent(s) comprising the following step:
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising one or more pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier.
  • a hair care active agent(s) comprising the following steps:
  • a hair care active agent(s) comprising the following step:
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising at least two sets of pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier and wherein the alignment of the first set of displaced dipolar magnetic elements is angularly offset relative to the alignment of the second set of displaced dipolar magnetic elements.
  • a hair care active agent comprising the following steps:
  • the effect of a traditional uniform magnetic or electro-magnetic field on the dielectric tissues of the hair shaft results in ionic polarization across the entire magnetic flux gradient rather than across adjacent regions. Polarization over such large distances limits the potential for enhanced micro fluidic flow.
  • the use of one or more pairs of displaced dipolar magnetic elements linked by a magnetic return creates dielectric polarisation in closely adjacent regions that act to enhance micro-fluidic flow.
  • the present inventors have now identified that the utility of a magnetic field in enhanced delivery of active agents in hair care and cosmetic applications can be increased not just by increasing the strength of an individual magnetic field, but also by taking advantage of the differences between the flux of two magnetic fields of alterative polarity and orientation.
  • the present invention thus allows dielectric polarization to be used to increase the permeability of target tissues in conjunction with the use of diamagnetic repulsion to enhance diffusion of active agents across barriers in such a manner that one effect does not negate the benefit of the other.
  • the inventors of the present invention believe that increasing the utility of the magnetic flux in this manner has a number of advantageous effects. It is known that increasing the magnetic flux increases the diamagnetic repulsion of the active agent away from the magnetic source and towards the target biological barrier. This is a feature of diamagnetic susceptibility and is related to the paired electrons of diamagnetic molecules being repelled by magnetic fields. In this way, diamagnetic repulsion provides a means of adding directionality and mobility to molecules during diffusion.
  • the inventors further believe that that dielectric polarization of ionic species in target barriers could act to enhance penetration of active agents through induced osmotic and ionic effects.
  • the inventors also believe that the increased flux, particularly perpendicular magnetic flux between two opposite poles, temporarily modifies or alters the barrier function and permeability, changing the microfluidic flow without permanently changing the physical structure of the surface.
  • the inventors of the present invention also believe that the diamagnetic repulsive effects of traditional uniform magnetic and electromagnetic fields tend to act contrary to the dielectric polarisation and therefore tend to cancel any benefit.
  • the inventors of the present invention thus believe that the present inyention, comprising various arrangements of displaced dipolar magnetic pairs, allows diamagnetic repulsion to be maintained in the presence of dielectric polarization, thus providing an effective means of influencing molecular movement and permeation enhancements of barriers during the delivery of active agents.
  • Each pair of displaced dipolar magnetic elements of the present invention may, for the purposes of visualisation, be thought of in terms of a single traditional rod dipolar magnetic that is cleaved or broken around its central point and the two resulting sections rotated through 180° and brought together such that the opposite poles are adjacent (see, for example, Figure 1).
  • the magnetic return is used to integrate the magnetic fields at the point of cleavage.
  • the result is a dipolar pair, displaced horizontally so as to provide both a perpendicular and a horizontal magnetic flux gradient.
  • each individual dipole provides diamagnetic repulsion to the active agents that are to be transported across the biological barrier, whilst the horizontal flux between each dipole pair acts to polarize the dielectric properties of the target tissue such as hair shaft, hair follicle or scalp/dermis, inducing permeation changes.
  • the device of the present invention may comprise one pair of displaced dipolar magnetic elements, or may preferably comprise a number of pairs of displaced dipolar magnetic elements.
  • Figure 1 shov s a variety of arrangements of dipole pairs, arranged in rows or grids.
  • the terms "pair” and “pairs” are used variously in the present specification, and reference to a single pair of displaced dipolar magnetic elements may be taken to also refer to multiple pairs of displaced dipolar magnetic elements.
  • the polarity of one pair of displaced dipolar magnetic elements may be in the same orientation as that of the neighbouring pair of displaced dipolar magnetic elements (i.e. the series may comprise [NS][NS][NS]) or may be in the opposite orientation (i.e. the series may comprise [NS][SN][NS]) (see Figure 1).
  • a magnetic device for the delivery of a hair care active agent(s) comprising:
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising one or more pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier.
  • a magnetic device for the delivery of a hair care active agent(s) comprising:
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising one or more pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier; and (b) moving in a reciprocal, rotational or orbital manner the magnetic device so that active agents in proximity to said device will be subject to alternating polarities of magnetic flux in response to said reciprocal, rotational or orbital movement.
  • a magnetic device for the delivery of a hair care active agent(s) comprising:
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising at least two sets of pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier and wherein the alignment of the first set of displaced dipolar magnetic elements is angularly offset relative to the alignment of the second set of displaced dipolar magnetic elements.
  • a magnetic device for the delivery of a hair care active agent(s) comprising:
  • a target biological barrier comprising a hair shaft, follicle or scalp and a magnetic device comprising at least two sets of pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier and wherein the alignment of the first set of displaced dipolar magnetic elements is angularly offset relative to the alignment of the second set of displaced dipolar magnetic elements
  • use of the present invention to increase the penetration of hair dye into the hair shaft may lead to an improvement in the intensity of the hair colour and decreased use of hair dye (due to both a need for less hair dye to achieve the same results and deeper penetration resulting in a longer lasting colour change), or use of the invention to increase the penetration of depilatory agents into the scalp may lead to more effective hair removal and use of less active agent due to the need for less depilatory agent to achieve the same effect.
  • a magnetic return according to the present invention is a member that is adjacent to one surface of each of the members of the dipolar pair, passing from the positive polar surface of one of the pair of displaced dipolar magnetic elements to the negative polar surface of the other member of the pair of displaced dipolar • magnetic elements wherein the magnetic return integrates the magnetic fields on those surfaces and reduces or eliminates the magnetic flux on those surfaces.
  • the magnetic return may extend further to unite one set of dipole pairs with another set of dipole pairs, or a larger group of dipole pairs.
  • the magnetic return is preferably located on the surfaces of the dipole pair distal to the biological surface to which the magnetic fields are desired to be applied.
  • the magnetic return can be composed of any material that is magnetically conductive.
  • the material is a ferromagnetic material such as an iron compound (e.g. a ferrite such as barium ferrite, magnetite, or mild steel), a cobalt material, a strontium material, a barium material or a nickel material.
  • the material may have a metalloid component such as boron, carbon, silicon, phosphorus or aluminium.
  • Rare earth material such as neodymium or samarium may also be used.
  • the magnetic return preferably links the pair of displaced dipolar magnetic elements by covering all or at least some of one polar surface of the first magnet of the pair, and all or at least some of the opposite polar surface of the second magnet of the pair.
  • the device may also comprise, a housing for the pairs of displaced dipolar magnetic elements.
  • the housing does not interfere with the generated magnetic fields.
  • the movement described herein may be either through manual operation or through mechanical means.
  • manual > operation ie through normal consumer actions such as brushing or scrubbing
  • the frequency will be in the order of 1 Hz to 5 Hz.
  • the strength of the magnet field produced by each element of the magnet array should be between about 100 and 500 Gauss.
  • movement is delivered through mechanical or electrical means (such as in the form of a electrical brush like an electrical tooth brush)
  • the oscillation should be in the order of approximately 100 and 8,000 Hz with a magnet flux of between about 100 and 1000 Gauss.
  • rotational includes movement in an arc-like, semi-circular, circular or orbital manner.
  • the magnetic device includes a means for moving the magnetic device over the hair shaft, follicle or scalp.
  • a means will include any mechanism, electronic or mechanical, adapted for reciprocal or rotational movement of the magnetic material.
  • the magnetic material may be associated with a drive mechanism that is capable of reciprocal movement.
  • magnetic materials include, without limitation: a. arrangements where individual segments or sections of magnetized ferromagnetic materials are assembled in the configuration described herein; and b. arrangements where magnetic particles or elements are disposed in a solid or semi-solid matrix or base and the required magnetic pattern is impressed upon the ferromagnetic particles.
  • the present invention may be constructed using a range of magnetic materials exhibiting ferromagnetic properties.
  • Such materials may include Iron, Strontium, Barium, Cobalt or Nickel with a metalloid component such as Boron, Carbon, Silicon, Phosphorus or Aluminium.
  • rare-earth materials such as Neodymium or Samarium-cobalt may also be used.
  • Such ferromagnetic materials may be deployed as rigid elements within a device or encapsulated in a flexible matrix such as rubber or silicone.
  • each pair of displaced dipolar magnetic elements of the present invention has a horizontal offset between centres of between 1 and 10 millimetres, preferably 3 and 7 millimetres.
  • pairs of displaced dipolar magnetic elements may be disposed at a repetition rate of between 2 and 10 dipolar pairs per centimetre, more preferably 1.5 and 4 dipolar pairs per centimetre.
  • the poles in a particular spatial region are between 1.0 mm to 10mm apart, more preferably, the poles are between 1.0 mm to 5.0mm apart.
  • the magnetic flux of each magnetic pole is between about 10 Gauss and about 1000 Gauss.
  • the flux of each pole is between about 100 Gauss to about 600 Gauss, most preferably about 125 to 450 Gauss.
  • the difference or delta flux between the magnetic flux of two adjacent poles of opposite polarity is between about 100 Gauss and about 2000 Gauss. More preferably, the difference between the magnetic flux of two adjacent poles of opposite polarity is between about 200 Gauss to about 1400 Gauss, most preferably about 200 to 900 Gauss.
  • the orientation of the first set of dipolar pairs is preferably between about 1° and 90° relative to the second set of dipole pairs.
  • the degree of angular offset is at least 10°, more preferably at least 45°, most preferably between about 45° and 90°.
  • Figures 2 and 3 provide examples of arrangements of sets of pairs of displaced dipolar magnetic elements. Such magnetic devices with at least two sets of pairs of displaced magnetic elements may have a different number of dipolar pairs disposed in the first set from that in the second set. For example, the first set of dipolar pairs may have two dipolar pairs per centimetre whilst the second set may have five dipolar pairs per centimetre.
  • the magnetic fields will be complex and exhibit different flux densities in each orientation, as the fields produced by the first set of dipolar pairs will sum with that of the second set of dipolar pairs at the points of constructive and destructive interference and by doing so provide a net field of higher magnetic strength, higher magnet flux and higher magnetic gradient, all of which will add to the utility of the present invention.
  • induction effect is reliant on the target barrier being influenced by an alternating field, which only happens when the device is tracked across the barrier at 90° to the alignment of the elements.
  • the arrays are aligned so to produce an AC like induction, irrespective of the direction of motion; and (ii) To induce opposing charges in adjacent areas of the barrier so to produce streaming potentials to accommodate pathways that are not perpendicular to the field flux, such as vertical shunts or pathways.
  • the device may further comprise more than two sets of dipolar pairs.
  • the orientation of these further sets of pairs of displaced dipolar magnetic elements may align with the first set of pairs of displaced dipolar magnetic elements and thus be angularly offset to the second set of pairs of displaced dipolar magnetic elements, or may align with the second set and thus be angularly offset to the first set of pairs of displaced dipolar magnetic elements.
  • Further orientations and arrangements of sets of pairs of displaced dipolar magnetic elements may be provided which align with either the first or second sets of displaced dipolar magnetic elements.
  • a many layered device may be provided which comprises a number of orientation of pairs of displaced dipolar magnetic elements stacked on top of each other, each one aligned in a different orientation to the array below (e.g. each set aligned perpendicular to the set below).
  • the target surface which comprises the biological barrier in relation to a hair care products may be selected from the following list: hair shaft (medulla, cortex and/or cuticle), hair follicle (dermal papilla, follicle, sebaceous gland) and/or scalp or dermis.
  • hair shaft medulla, cortex and/or cuticle
  • hair follicle dermal papilla, follicle, sebaceous gland
  • scalp or dermis the device is preferentially adapted to deliver active agent(s) across the biological barrier of hair shaft, hair follicle or dermis.
  • Such biological barriers may have micro channels, apertures, pores etc through which active agents can be delivered.
  • the method of the invention provides a means for driving the passage of active agent(s) across the barrier formed by a target biological barrier such as a hair shaft, hair follicle or dermis etc into a subject (including a patient).
  • the method may be enhanced by the additional step of pairing the device with an alternate drug delivery system that operates either in conjunction with, or in parallel with, the device, to promote the passage of active agents through the biological barrier.
  • alternate drug delivery systems may - 2.1 - include, for example, iontophoresis, drug-adhesive matrix, chemical penetration enhancers, micro-needles and sonophoresis.
  • the process of enhanced delivery by the present invention involves the utilization of magnetic principles to apply force upon active agent(s) in such a manner as to ensure that the force acting upon the agents is different from that acting upon the molecules of the vehicle, gel or solvent.
  • another method of improving the utility of the invention is to select or chemically alter the diamagnetic sensitivity of the active agent or that of the vehicle, gel or solvent in which it is located with the view to enhancing the differences in dimagnetic sensitivity between the two entities.
  • the additional of a light ester such as phenxyethyl acrylate to a diethylaminoethyl acrylate polymer may act to increase the dimagnetic susceptibility of the polymer and by doing so increase the delivery of a diamagnetic target molecule from that vehicle, gel or solvent.
  • the device is preferably in the form of a brush.
  • the pairs of displaced dipolar magnetic elements may be incorporated into the brush in the form of: a sheet within the head of the brush (either immediately below the bristles, distal to the head of the brush from the bristles or forming one surface of a brush which does not have any bristles); the bristles of the brush themselves; panels of pairs of displaced dipolar magnetic elements which replace the traditional bristles; balls or domes which cap the ends of the bristles.
  • the active agent may be located on some or all of the bristles or panels of the brush or applied separately to the biological barrier to which the brush is applied.
  • the plurality of displaced dipolar magnetic pairs will act upon the active agent, enhancing diffusion of the active and enhancing delivery and bioavailability at the biological barrier formed by the hair shaft, hair follicle or dermis whose permeability has been alter by the magnetic effects of the displaced dipolar magnetic pairs.
  • the device is formed as a pad comprising a sheet of pairs of displaced dipolar magnetic elements, a flexible or rigid backing panel and a handle.
  • the pad device may be rubbed over the head, the movement of the pad comprising the magnetic component enhancing the penetration of the active agents in accordance with the method of the present invention.
  • the active agent may be releasably contained within the pad, with the active agent(s) present within the pad, permeating the pad and being capable of diffusing out of the pad and penetrating the biological barrier.
  • the active agents may be applied to the biological barrier prior to rubbing the pad over the head.
  • Another form of the invention comprises a flexible membrane, such as a plastic film or woven piece of fabric, wherein the pairs of displaced dipolar magnetic elements are provided as a sheet adhered to one side of the membrane.
  • the membrane may comprise a flexible matrix within which the pairs of displaced dipolar magnetic elements are distributed.
  • the flexible membrane may be rubbed over the head.
  • the device may comprise a roller applicator or pen device wherein the pairs of displaced dipolar magnetic elements are located in the roller or pen nib which can be moved or rubbed over the head to allow the active agent to penetrate the biological barrier.
  • the active agent may be applied to the device prior to it being rubbed over the surface, or the active agent may be applied to the surface prior to the device being rubbed or moved over it.
  • the active agent(s) delivered by the device of the invention may cover the entire region of the contact zone between the device and the biological barrier comprising the hair shaft, hair follicle or dermis or alternatively may be formed in islands therein.
  • active agents which could be delivered using the method of the present invention to, for example, the hair shaft, include: a) Hair dye: such as semipermanent, demi-permanent and/or permanent hair dyes, henna, indigo etc; b) Bleaching agents: such as peroxide etc; c) Hair strengthened: such as silica, proteins e.g. keratin, oils e.g. carrot oil, etc; d) Conditioning and moisturizing agents: such as silk, wheat and keratin proteins, panthenol, biotin.
  • Non-limiting examples of active agents which could be delivered using the method of the present invention to, for example, the hair follicle include: a) Depilatory agents; such as calcium or potassium thioglycolate; b) Hair growth inhibitors; such as enzyme inhibitors e.g. eflornithine hydrochloride; c) Hair growth stimulators: such as minoxidil, nicotinic acid, retin-A.
  • Non-limiting examples of active agents which could be delivered using the method of the present invention to, for example, the scalp or dermis of the head include: a) Moisturising agents and emollients: occlusive agents e.g. hydrocarbons such as petrolatum, silicone containing agents such as dimethicone, cyclomethicone, fatty acids and alcohols such as lanolin acid or alcohol, sterols such as cholesterol, waxes and fats such as cocoa butter, carnuba wax and bees wax; humectants e.g. glycosamines such as hyaluronic acid, glycerine, honey, urea, lactic acid, a-hydroxy acids, propylene glycol etc.
  • occlusive agents e.g. hydrocarbons such as petrolatum, silicone containing agents such as dimethicone, cyclomethicone, fatty acids and alcohols such as lanolin acid or alcohol, sterols such as cholesterol, waxes
  • Additional agents that could be delivered to the hair and scalp surfaces include nutritional type ingredients, such as vitamins, minerals, amino acids, vitamin E, oils such as rosemary, jojoba, almond, lavender, tea tree, olive and carrot oil, and folic acid; sensate ingredients, such as those providing cooling (such as menthol), tingle, or heat sensations (such as capsaicin or capsicum oil); colorants or other aesthetic agents; and combinations thereof.
  • nutritional type ingredients such as vitamins, minerals, amino acids, vitamin E, oils such as rosemary, jojoba, almond, lavender, tea tree, olive and carrot oil, and folic acid
  • sensate ingredients such as those providing cooling (such as menthol), tingle, or heat sensations (such as capsaicin or capsicum oil); colorants or other aesthetic agents; and combinations thereof.
  • essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit,
  • active agent(s) may be applied in a controlled manner, using the method of the present invention. This list is not exhaustive. Preferably, any active agent(s) that can be delivered topically can potentially be delivered using the present invention.
  • each of the agents described above can be delivered to the hair shaft, the hair follicle and/or the scalp or dermis.
  • the depilatory agents may be delivered to the hair follicle or the scalp or both.
  • the active agent may be in the form of a gel, paste, liquid, thermo-reversible gel or paste, etc.
  • the active agent(s) may be in the form of shampoo or hair gel.
  • the active agent(s) may be provided and used alone with the device, in many situations the active agent will be included in a formulation either alone or in combination with one or more other active agents.
  • the formulation is to provide a pharmaceutical and/or biopharmaceutical benefit, the number of active agent(s) included in the formulation may preferentially be quite selective. Where the formulation provides a nutraceuticals, cosmetic and/or cosmeceutical effect, the number of active agents may be much greater in number.
  • the formulation employed in the delivery process may include additives such as other buffers, diluents, carriers, adjuvants or excipients.
  • Any pharmacologically acceptable buffer that is magnetically inert or neutral or which has a magnetic susceptibility that is either paramagnetic in nature or greater than that of the active agent(s) being delivered may be used, e.g., tris or phosphate buffers.
  • Other agents may be employed in the formulation for a variety of purposes. For example, buffering agents, preservatives, co-solvents, surfactants, oils, humectants, emollients, chelating agents, stabilizers or antioxidants may be employed.
  • Water soluble preservatives which may be employed include, but are not limited to, benzalkonium chloride, chlorobutanol, thimerosal, sodium bisulfate, phenylmercuric acetate, phenylmercuric nitrate, ethyl alcohol, methylparaben, polyvinyl alcohol, benzyl alcohol and phenylethyl alcohol.
  • a surfactant may be Tween 80.
  • Other vehicles that may be used include, but are not limited to, polyvinyl alcohol, povidone, hydroxypropyl methyl cellulose, poloxamers, carboxymethyl cellulose, hydroxyethyl cellulose, purified water, etc.
  • Tonicity adjustors may be included, for example, sodium chloride, potassium chloride, mannitol, glycerin, etc.
  • Antioxidants include, but are not limited to, sodium metabisulfite, sodium thiosulfate, acetylcysteine, butylated hydroxyanisole, butylated hydroxytoluene, etc.
  • the indications, effective doses, contra-indications, vendors etc, of the active agents in the formulations are available or are known to one skilled in the art.
  • the active agents may be present in individual amounts of from about 0.001 to about 5% by weight and preferably about 0.01% to about 2% by weight. However, it is contemplated that the active agents may be present in individual amounts greater than this, for example up to 100%.
  • Suitable water soluble buffering agents that may be employed include sodium carbonate, sodium borate, sodium phosphate, sodium acetate, sodium bicarbonate, etc., as approved by the US FDA for the desired route of administration. These agents may be present in amounts sufficient to maintain a pH of the system of between about 2 to about 9, preferably about 4 to about 8, more preferably 4.5, 5, 5.5, 6, 6.5, 7 or 7.5 (or any pH in between). As such the buffering agent may be as much as about 5% on a weight to weight basis of the total formulation. Electrolytes such as, but not limited to, sodium chloride and potassium chloride may also be included in the formulation where appropriate.
  • the active agents to be delivered using the device of the present invention may be provided in a matrix layer. If the active agent delivered by the device of the present invention is contained within a matrix, the matrix preferably allows the active agent to diffuse or exit the matrix in some manner and contact the biological barrier, perhaps by moving down the bristles of the brush to the biological barrier.
  • the matrix is preferentially prepared from a polymer or copolymer prepared from e.g., polyisobutylene, ester of polyvinyl alcohol, polyacrylic and polymethacrylic acid esters, natural rubber, polymers of styrene, isoprene, and styrene-butadiene or silicone polymers, resin components, such as, saturated and unsaturated hydrocarbon resins, derivatives of abietyl alcohol and of beta-pinene, plasticizers, such as phthalic acid esters, triglycerides and fatty acids, as well as a series of other substances known to those skilled in the art.
  • a polymer or copolymer prepared from e.g., polyisobutylene, ester of polyvinyl alcohol, polyacrylic and polymethacrylic acid esters, natural rubber, polymers of styrene, isoprene, and styrene-butadiene or silicone polymers, resin components, such as, saturated and
  • Matrix biocompatible polymers that might be used in the invention include compounds such as polycaprolactone, polyglycolic acid, polylactic acid, polyanhydrides, polylactide-co-glycolides, polyamino acids, polyethylene oxide, acrylic terminated polyethylene oxide, polyamides, polyethylenes, polyacrylonitriles, polyphosphazenes, poly(ortho esters), sucrose acetate isobutyrate (SAIB), and other polymers such as those disclosed in U.S. Patent Nos.
  • SAIB sucrose acetate isobutyrate
  • the matrix containing the active agents may also be prepared from thermosetting polymers such as tetra-substituted ethylene diamine block copolymers of ethylene oxide and propylene oxide (e.g., poloxamine); polycarbophil; and polysaccharides such as gellan, carrageenan (e.g., kappa-carrageenan and iota-carrageenan), chitosan and alginate gums.
  • the matrix may also be a hydrogel, being a gel prepared with hydrophilic polymers, and these materials are well known in the art, frequently being used as part of biomedical electrodes, such as are described in U.S. Pat. Nos.
  • hydrophilic polymers useful for the preparation of hydrogels are polyacrylate, polymethacrylate, polyacrylamide, polyvinyl alcohol), polyethylene oxide), poly(ethylene imine), carboxy-methylcellulose, methylcellulose, poly(acrylamide sulphonic acid), polyacrylonitrile, poly(vinyl-pyrrolidone), agar, dextran, dextrin, carrageenan, xanthan, and guar.
  • the preferred hydrogels are acrylates and may be, for example, preferably made from acrylic esters of quaternary chlorides and/or sulfates or acrylic amides of quaternary chlorides; polymers of this type are disclosed in U.S. Pat. No. 5,800,685, incorporated herein by reference.
  • the hydrophilic polymers will generally constitute from about 1 to about 70%, preferably about 5 to about 60%, more preferably about 10 to about 50%, by weight of the hydrogel.
  • a topical formulation for delivery to a subject is prepared by selecting a desired amount of active agent. The agent is then preferably placed in a suitable delivery matrix. The amount of the active agent to be administered and the concentration of the compound in the topical formulation depends upon the diluent, delivery system or device selected, the clinical or cosmetic condition of the subject, the side effects and the stability of the active agent in the matrix.
  • the dye was applied manually to the hair swatches and the sample designated as Active (A) was placed on an oscillating test bed apparatus in which arrays of pairs of displaced dipolar magnetic elements comprising flexible ETP008 magnetic material formed of a parallel linear array of displaced dipolar magnetic elements with common pole pairs of 450 gauss peak flux with a centre to centre spatial separation of 4 mm were moved back and forward over the hair at a rate of 3 Hz to simulate brushing of the hair, which resulted in a a magnetic field-in-motion (also known as a magnetic FIM).
  • the passive or control swatch (P) was placed on the test bed in an area not influenced by the magnetic array. After 5 minutes, both samples of hair were washed to remove the dye, then dried and photographed.
  • Magnetic array Type ETP008 is a parallel linear array of common pole pairs of 450 gauss peak flux with a centre to centre spatial separation of 4 mm.
  • VEET A commercial hair removal cream
  • Optical Microscopy apparatus Vanox, Olympus fitted with a digital camera (Dino-Lite digital microscope) and computer software capable of processing optical microscopy images, including the measurement of length (DinoCapture).
  • wild boar skin was obtained directly from the slaughterhouse as a whole skin and cut into approximately 10cm x 10cm sections and stored, wrapped in aluminium foil, at -20°C. Prior to use, the segments were defrosted and the hair on each segment was trimmed to a uniform length (approx. 3 mm) using standard powered hair clippers.
  • a known volume of commercial hair removal cream was applied to half (5cm x 10cm portion) of a 10cm x 10cm piece of wild boar skin in the manner described by the manufacturer's instructions ie. smoothed onto the skin using a gloved hand using a backwards and forwards rubbing motion and a fixed number of rubbing movements.
  • At least three representative slices of skin of approximately 0.5 mm thickness and 10 cm long were cut from the centre portion of each application region and the excise portions mounted on glass microscope slides.
  • the effect of the ETP003 magnetic array on the chemical hair removal process was determined by examining the rate of hair cleavage.
  • ETP 003 active flexible array matrix
  • VEET A commercial hair removal cream
  • Non-magnetic apparatus capable of clamping locks of human hair in a fixed position (example diagram Figure 15). i.e. two (1cm x 4cm x 25cm) hard plastic blocks, one of which is fitted with a 1.8 mm thick rubber sheet to grip the hair. The blocks are clamped in place using two standard F-clamps, one at each end of the clamping blocks (F-clamps not shown). 7) Electronic timer Method
  • Table 1 "Time to cleavage" data for human hair samples in the presence of hair removal cream, control, FIM or passive application. Seconds Seconds

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Abstract

L'invention concerne un procédé de délivrance d'un agent actif de soin capillaire comprenant l'étape suivante : l'application d'un ou de plusieurs agents actifs entre une barrière biologique cible comprenant une tige de cheveu, un follicule ou un cuir chevelu, et un dispositif magnétique comprenant une ou plusieurs paires d'éléments magnétiques dipolaires déplacés reliés par un retour magnétique, le retour magnétique étant orienté sur les surfaces de la paire de dipôles distale de la barrière biologique.
PCT/AU2011/000618 2010-05-25 2011-05-24 Délivrance de produits de soin capillaire WO2011146977A1 (fr)

Applications Claiming Priority (2)

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AU2010902282 2010-05-25
AU2010902282A AU2010902282A0 (en) 2010-05-25 Delivery of Hair Care Products

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044552A1 (fr) * 2014-09-17 2016-03-24 The Procter & Gamble Company Produit de soin de la peau et procédé d'utilisation
WO2016044567A1 (fr) * 2014-09-17 2016-03-24 The Procter & Gamble Company Produits de soins de peau
USD846751S1 (en) 2017-08-23 2019-04-23 The Procter And Gamble Company Cosmetic skin care device
US10322270B2 (en) 2014-09-17 2019-06-18 The Procter & Gamble Company Skin care applicator

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020147424A1 (en) * 2000-12-26 2002-10-10 Alvin Ostrow Transdermal magnetic drug delivery system and method
US20090093669A1 (en) * 2007-10-05 2009-04-09 Farone William A Magnetophoresis apparatus and method of use
WO2009135246A1 (fr) * 2008-05-07 2009-11-12 Obj Limited Procédé et appareil pour une diffusion transdermique améliorée

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020147424A1 (en) * 2000-12-26 2002-10-10 Alvin Ostrow Transdermal magnetic drug delivery system and method
US20090093669A1 (en) * 2007-10-05 2009-04-09 Farone William A Magnetophoresis apparatus and method of use
WO2009135246A1 (fr) * 2008-05-07 2009-11-12 Obj Limited Procédé et appareil pour une diffusion transdermique améliorée

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044552A1 (fr) * 2014-09-17 2016-03-24 The Procter & Gamble Company Produit de soin de la peau et procédé d'utilisation
WO2016044567A1 (fr) * 2014-09-17 2016-03-24 The Procter & Gamble Company Produits de soins de peau
CN106794130A (zh) * 2014-09-17 2017-05-31 宝洁公司 护肤产品和使用方法
US10034827B2 (en) 2014-09-17 2018-07-31 The Procter & Gamble Company Skin care product and method of use
US10058495B2 (en) 2014-09-17 2018-08-28 The Procter & Gamble Company Method of making a skin care product
US10322270B2 (en) 2014-09-17 2019-06-18 The Procter & Gamble Company Skin care applicator
USD846751S1 (en) 2017-08-23 2019-04-23 The Procter And Gamble Company Cosmetic skin care device

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