WO2011132989A3 - 자궁경부암 진단용 메틸화 마커 - Google Patents

자궁경부암 진단용 메틸화 마커 Download PDF

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WO2011132989A3
WO2011132989A3 PCT/KR2011/002942 KR2011002942W WO2011132989A3 WO 2011132989 A3 WO2011132989 A3 WO 2011132989A3 KR 2011002942 W KR2011002942 W KR 2011002942W WO 2011132989 A3 WO2011132989 A3 WO 2011132989A3
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WIPO (PCT)
Prior art keywords
cervical cancer
diagnosis
specifically
present
methylation marker
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PCT/KR2011/002942
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English (en)
French (fr)
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WO2011132989A2 (ko
Inventor
안성환
문영호
오태정
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(주)지노믹트리
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Priority to US13/642,407 priority Critical patent/US20130116144A1/en
Publication of WO2011132989A2 publication Critical patent/WO2011132989A2/ko
Publication of WO2011132989A3 publication Critical patent/WO2011132989A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

본 발명은 자궁경부암 진단을 위한, 자궁경부암 특이적인 바이오 마커에 관한 것으로, 더욱 자세하게는 자궁경부암 세포에서 특정유전자의 CpG섬 부위가 특이적으로 메틸화되는 자궁경부암 특이적 바이오 마커의 메틸화를 검출하여 자궁경부암 진단을 위한 정보를 제공하는 방법에 관한 것이다. 더욱 자세하게는 본 발명의 진단용 키트 및 진단용 핵산 칩을 이용하면, 자궁경부암을 초기 형질전환 단계에서 진단할 수 있어, 조기 진단이 가능하고, 고위험군에 대한 진행을 예측할 수 있어 통상적인 방법보다 정확하고 빠르게 자궁경부암을 스크리닝 할 수 있다.
PCT/KR2011/002942 2010-04-23 2011-04-22 자궁경부암 진단용 메틸화 마커 WO2011132989A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/642,407 US20130116144A1 (en) 2010-04-23 2011-04-22 Methylation marker for diagnosis of cervical cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100037710A KR101374822B1 (ko) 2010-04-23 2010-04-23 자궁경부암 진단용 메틸화 마커
KR10-2010-0037710 2010-04-23

Publications (2)

Publication Number Publication Date
WO2011132989A2 WO2011132989A2 (ko) 2011-10-27
WO2011132989A3 true WO2011132989A3 (ko) 2012-04-12

Family

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Country Status (3)

Country Link
US (1) US20130116144A1 (ko)
KR (1) KR101374822B1 (ko)
WO (1) WO2011132989A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101486878B1 (ko) * 2014-07-15 2015-02-05 대한민국 자궁경부암 진단을 위한 메틸화 바이오마커
HUE057564T2 (hu) 2014-09-22 2022-06-28 Univ Groningen Méhnyakrák biomarkerei
KR101804324B1 (ko) 2015-04-13 2017-12-04 연세대학교 산학협력단 자궁경부암 유발시 발현이 증가하는 lncRNA를 이용하는 자궁경부암 진단 또는 예후 분석용 바이오마커, 키트 및 스크리닝 방법
CN107760788B (zh) * 2017-12-05 2021-03-02 武汉艾米森生命科技有限公司 一种检测宫颈细胞基因甲基化的核酸组合及试剂盒与应用
CN117867106A (zh) * 2022-01-04 2024-04-12 博尔诚（北京）科技有限公司 用于宫颈癌筛查的标志物、探针组合物及其应用

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
EP1985715A3 (en) * 2004-07-16 2008-12-31 Oncomethylome Sciences, S.A. ESR1 and cervical cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HSU, M. C. ET AL.: "Uncoupling of promoter methylation and expression of Period1 in cervical cancer cells", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 360, no. 1, 17 August 2007 (2007-08-17), pages 257 - 262, XP022134260, DOI: doi:10.1016/j.bbrc.2007.06.042 *
LAI, H. C. ET AL.: "Identification of novel DNA methylation markers in cervical cancer", INT. J. CANCER, vol. 123, no. 1, 1 July 2008 (2008-07-01), pages 161 - 167, XP002543572, DOI: doi:10.1002/ijc.23519 *
PARK, S. Y. ET AL.: "Methylation profiles of CpG island loci in major types of human cancers", J. KOREAN MED. SCI., vol. 22, no. 2, April 2007 (2007-04-01), pages 311 - 317, XP055040124, DOI: doi:10.3346/jkms.2007.22.2.311 *
WANG, S. S. ET AL.: "Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning", CANCER RES., vol. 68, no. 7, 1 April 2008 (2008-04-01), pages 2489 - 2497, XP002566925, DOI: doi:10.1158/0008-5472.CAN-07-3194 *
WATKINS, P. A. ET AL.: "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome", J. LIPID RES., vol. 48, no. 12, December 2007 (2007-12-01), pages 2736 - 2750, XP055034984, DOI: doi:10.1194/jlr.M700378-JLR200 *
YE, F. ET AL.: "OPCML gene promoter methylation and gene expression in tumor and stroma cells of invasive cervical carcinoma", CANCER INVEST., vol. 26, no. 6, July 2008 (2008-07-01), pages 569 - 574 *

Also Published As

Publication number Publication date
WO2011132989A2 (ko) 2011-10-27
US20130116144A1 (en) 2013-05-09
KR101374822B1 (ko) 2014-03-17
KR20110118230A (ko) 2011-10-31

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