WO2011126537A3 - Oral adhering compositions that apply rhizophora mangle extract in the mouth - Google Patents

Oral adhering compositions that apply rhizophora mangle extract in the mouth Download PDF

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Publication number
WO2011126537A3
WO2011126537A3 PCT/US2011/000472 US2011000472W WO2011126537A3 WO 2011126537 A3 WO2011126537 A3 WO 2011126537A3 US 2011000472 W US2011000472 W US 2011000472W WO 2011126537 A3 WO2011126537 A3 WO 2011126537A3
Authority
WO
WIPO (PCT)
Prior art keywords
mouth
extract
oral
compositions
apply
Prior art date
Application number
PCT/US2011/000472
Other languages
French (fr)
Other versions
WO2011126537A2 (en
Inventor
Jeffrey T. Haley
Jeffrey T. Haley
Original Assignee
Orahealth Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orahealth Corporation filed Critical Orahealth Corporation
Publication of WO2011126537A2 publication Critical patent/WO2011126537A2/en
Publication of WO2011126537A3 publication Critical patent/WO2011126537A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Abstract

This invention is directed to compositions that adhere in the mouth to impede inflammation and promote resolution thereof in tissues of the oral mucosa, including mouth, throat, and esophagus, including gingivitis, periodontitis, laryngitis, esophagitis, mucositis, stomatitis, vestibulitis, aphthous ulcerations, and Behcet's syndrome, whether caused by bacterial or viral infections, trauma, or other cause. The compositions may be oral adhering discs or denture paste or oral gel that release Rhizophora Mangle extract.
PCT/US2011/000472 2010-04-05 2011-03-15 Oral adhering compositions that apply rhizophora mangle extract in the mouth WO2011126537A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32104710P 2010-04-05 2010-04-05
US61/321,047 2010-04-05

Publications (2)

Publication Number Publication Date
WO2011126537A2 WO2011126537A2 (en) 2011-10-13
WO2011126537A3 true WO2011126537A3 (en) 2012-01-19

Family

ID=44763446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/000472 WO2011126537A2 (en) 2010-04-05 2011-03-15 Oral adhering compositions that apply rhizophora mangle extract in the mouth

Country Status (1)

Country Link
WO (1) WO2011126537A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9789061B2 (en) * 2012-02-19 2017-10-17 Orahealth Corp. Acacia gum adhesive with calcium carbonate for oral adhering discs
BR102012028815A2 (en) * 2012-11-09 2015-05-26 Unicamp Pharmaceutical compositions containing fraction obtained from rhizophora mangle extract and their use
BR102013005019A2 (en) * 2013-02-27 2016-02-16 Unicamp pharmaceutical compositions containing procyanidins from rizophora mangle bark fractions
WO2015056196A1 (en) * 2013-10-16 2015-04-23 Orahealth Corporation Treating mucosal lesions with hyaluronan delivered from an adhering troche
WO2015116860A1 (en) * 2014-01-29 2015-08-06 Vita Ice Therapeutics Llc Edible oil compositions to treat oral complications and methods of using same
US20180296466A1 (en) * 2017-04-16 2018-10-18 Orahealth Corp. Gelatin and compression binder for use in oral adhering discs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037673A1 (en) * 1996-04-04 1997-10-16 Censaym Inc. PHARMACEUTICAL FORMULATIONS OF $i(RHIZOPHORA MANGLE L)
US20020136752A1 (en) * 2001-02-14 2002-09-26 Gw Pharmaceuticals Limited Pharmaceutical formulations
US20050228066A1 (en) * 2000-10-10 2005-10-13 Block Drug Co. Inc. Film extruded denture adhesive liner
US20070104783A1 (en) * 2001-02-28 2007-05-10 Axiomedic Ltd. Double-Layered Absorbable Solid Compositions for the Topical Treatment of Oral Mucosal Disorders
WO2009036084A2 (en) * 2007-09-11 2009-03-19 Orahealth Corporation Adhering troches with topically active ingredients for treatment of throat, esophagus, and stomach

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037673A1 (en) * 1996-04-04 1997-10-16 Censaym Inc. PHARMACEUTICAL FORMULATIONS OF $i(RHIZOPHORA MANGLE L)
US20050228066A1 (en) * 2000-10-10 2005-10-13 Block Drug Co. Inc. Film extruded denture adhesive liner
US20020136752A1 (en) * 2001-02-14 2002-09-26 Gw Pharmaceuticals Limited Pharmaceutical formulations
US20070104783A1 (en) * 2001-02-28 2007-05-10 Axiomedic Ltd. Double-Layered Absorbable Solid Compositions for the Topical Treatment of Oral Mucosal Disorders
WO2009036084A2 (en) * 2007-09-11 2009-03-19 Orahealth Corporation Adhering troches with topically active ingredients for treatment of throat, esophagus, and stomach

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CURRENT MEDICAL RESEARCH AND OPINION, vol. 21, no. 11, 2005, pages 1711 - 1715 *

Also Published As

Publication number Publication date
WO2011126537A2 (en) 2011-10-13

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