WO2011123587A1 - Adjustable chromophore compounds and materials incorporating such compounds - Google Patents

Adjustable chromophore compounds and materials incorporating such compounds Download PDF

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Publication number
WO2011123587A1
WO2011123587A1 PCT/US2011/030634 US2011030634W WO2011123587A1 WO 2011123587 A1 WO2011123587 A1 WO 2011123587A1 US 2011030634 W US2011030634 W US 2011030634W WO 2011123587 A1 WO2011123587 A1 WO 2011123587A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
chromophore
adjustable
chemical moiety
lens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/030634
Other languages
English (en)
French (fr)
Inventor
Joseph I. Weinschenk Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Priority to CA2794284A priority Critical patent/CA2794284C/en
Priority to JP2013502825A priority patent/JP2013523961A/ja
Priority to EP20110715630 priority patent/EP2553501B1/en
Priority to RU2012146774/04A priority patent/RU2563640C2/ru
Priority to ES11715630.7T priority patent/ES2474094T3/es
Priority to BR112012024962A priority patent/BR112012024962A2/pt
Priority to CN201180017513.8A priority patent/CN102844683B/zh
Priority to AU2011235140A priority patent/AU2011235140B2/en
Publication of WO2011123587A1 publication Critical patent/WO2011123587A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
    • B01J19/122—Incoherent waves
    • B01J19/123—Ultraviolet light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
    • B01J19/122—Incoherent waves
    • B01J19/127—Sunlight; Visible light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/00432—Auxiliary operations, e.g. machines for filling the moulds
    • B29D11/00461—Adjusting the refractive index, e.g. after implanting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C07D249/20—Benzotriazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
    • C08K5/3467—Heterocyclic compounds having nitrogen in the ring having more than two nitrogen atoms in the ring
    • C08K5/3472—Five-membered rings
    • C08K5/3475—Five-membered rings condensed with carbocyclic rings
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Definitions

  • B is a base chromophore compound
  • X is an adjustable chemical moiety that forms a remaining chemical moiety (C) upon exposure to predetermined electromagnetic radiation thereby forming the compound:
  • the chromophore compound B-X upon exposure to predetermined radiation, becomes the chromophore compound B-C and separable group (S) with the chromophore compound B-C having a conjugated double bond and the electron donating group (D) as well as the remaining group (C).
  • the base chromophore (B) then includes the electron withdrawing group (W).
  • the separable group (S) includes the mobilization inhibiting group (Z).
  • a chromophore compound B-X includes a benzotriazole base chromophore (B) and an adjustable moiety (X), which is a dicyclopentadiene.
  • a cyclic moiety of the base chromophore (B) and the dicyclopentadiene share a common bond.
  • the adjustable moiety (X) includes a mobilization inhibiting group (Z), which is preferably an alkane chain.
  • the base chromophore (B) includes an electron withdrawing moiety (W), which is preferably a halogen group and an electron donating group (D), which preferably includes an alkoxy group.
  • the chromophore compound B-X-B upon exposure to predetermined radiation, becomes two separate chromophore compounds B-C with each of the chromophore compounds B-C having a remaining group (C) with a conjugated double bond. Moreover, upon exposure to a second predetermined radiation, the chromophore compounds B-C can be reacted to become the single chromophore compound B-X-B.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Electromagnetism (AREA)
  • Polymers & Plastics (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Ophthalmology & Optometry (AREA)
  • Manufacturing & Machinery (AREA)
  • Eyeglasses (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Prostheses (AREA)
  • Optical Filters (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
PCT/US2011/030634 2010-04-02 2011-03-31 Adjustable chromophore compounds and materials incorporating such compounds Ceased WO2011123587A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2794284A CA2794284C (en) 2010-04-02 2011-03-31 Adjustable chromophore compounds and materials incorporating such compounds
JP2013502825A JP2013523961A (ja) 2010-04-02 2011-03-31 調節可能な発色団化合物およびそれら化合物を組み込んでいる材料
EP20110715630 EP2553501B1 (en) 2010-04-02 2011-03-31 Adjustable chromophore compounds and materials incorporating such compounds
RU2012146774/04A RU2563640C2 (ru) 2010-04-02 2011-03-31 Регулируемые хромофорные соединения и материалы, содержащие эти соединения
ES11715630.7T ES2474094T3 (es) 2010-04-02 2011-03-31 Compuestos de crom�foro ajustable y materiales que incorporan dichos compuestos
BR112012024962A BR112012024962A2 (pt) 2010-04-02 2011-03-31 compostos cromóforos ajustáveis e materiais que incorporam os mesmos
CN201180017513.8A CN102844683B (zh) 2010-04-02 2011-03-31 可调节发色团化合物及掺有该类化合物的材料
AU2011235140A AU2011235140B2 (en) 2010-04-02 2011-03-31 Adjustable chromophore compounds and materials incorporating such compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32044210P 2010-04-02 2010-04-02
US61/320,442 2010-04-02

Publications (1)

Publication Number Publication Date
WO2011123587A1 true WO2011123587A1 (en) 2011-10-06

Family

ID=44148789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/030634 Ceased WO2011123587A1 (en) 2010-04-02 2011-03-31 Adjustable chromophore compounds and materials incorporating such compounds

Country Status (12)

Country Link
US (3) US20110245818A1 (enExample)
EP (1) EP2553501B1 (enExample)
JP (3) JP2013523961A (enExample)
CN (1) CN102844683B (enExample)
AR (1) AR080739A1 (enExample)
AU (1) AU2011235140B2 (enExample)
BR (1) BR112012024962A2 (enExample)
CA (1) CA2794284C (enExample)
ES (1) ES2474094T3 (enExample)
RU (1) RU2563640C2 (enExample)
TW (1) TWI583673B (enExample)
WO (1) WO2011123587A1 (enExample)

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TWI583673B (zh) * 2010-04-02 2017-05-21 艾爾康股份有限公司 可調整之發色團化合物及併合該化合物之材料
TW201311621A (zh) 2011-08-15 2013-03-16 Novartis Ag 眼用鏡片材料之紫外光吸收劑
US9204962B2 (en) 2013-03-13 2015-12-08 Acufocus, Inc. In situ adjustable optical mask
EP3363794A1 (en) * 2017-02-15 2018-08-22 Merck Patent GmbH Bis-compounds for optically active devices
US12486403B2 (en) 2018-03-02 2025-12-02 Johnson & Johnson Vision Care, Inc. Polymerizable absorbers of UV and high energy visible light
US10935695B2 (en) 2018-03-02 2021-03-02 Johnson & Johnson Vision Care, Inc. Polymerizable absorbers of UV and high energy visible light
US11543683B2 (en) 2019-08-30 2023-01-03 Johnson & Johnson Vision Care, Inc. Multifocal contact lens displaying improved vision attributes
US12486348B2 (en) 2019-08-30 2025-12-02 Johnson & Johnson Vision Care, Inc. Contact lens displaying improved vision attributes
US11993037B1 (en) 2018-03-02 2024-05-28 Johnson & Johnson Vision Care, Inc. Contact lens displaying improved vision attributes
US11958824B2 (en) 2019-06-28 2024-04-16 Johnson & Johnson Vision Care, Inc. Photostable mimics of macular pigment

Citations (10)

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US4528311A (en) 1983-07-11 1985-07-09 Iolab Corporation Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles
US20020025401A1 (en) 2000-06-16 2002-02-28 Rolf Berg Optical storage using materials comprising chromophore oligomers which can undergo cycloaddition
US20040186241A1 (en) * 2003-03-20 2004-09-23 Gemert Barry Van Photochromic ocular devices
US20070077214A1 (en) 2005-10-03 2007-04-05 Biotechnology Research & Development Corporation Compositions comprising a uv-absorbing chromophore
WO2007140058A1 (en) * 2006-05-31 2007-12-06 Transitions Optical, Inc. Photochromic materials comprising metallocenyl groups
US20080090937A1 (en) 2006-10-13 2008-04-17 Alcon Manufacturing Ltd. Intraocular lenses with unique blue-violet cutoff and blue light transmission characteristics
US7396942B2 (en) 2003-01-09 2008-07-08 Alcon, Inc. Dual function UV-absorbers for ophthalmic lens materials
US20080242818A1 (en) 2007-03-05 2008-10-02 Benz Research And Development Corp. Light filters comprising a naturally occurring chromophore and derivatives thereof
US20090157178A1 (en) 2005-09-23 2009-06-18 Norbert Hampp Intraocular lens
US20100012889A1 (en) 2008-07-15 2010-01-21 Alcon, Inc. Uv-absorbers for ophthalmic lens materials

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CN1317535A (zh) 2001-02-23 2001-10-17 秦皇岛耀华玻璃股份有限公司 光致变色萘并吡喃化合物，制备方法及含此化合物的制品
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4528311A (en) 1983-07-11 1985-07-09 Iolab Corporation Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles
US20020025401A1 (en) 2000-06-16 2002-02-28 Rolf Berg Optical storage using materials comprising chromophore oligomers which can undergo cycloaddition
US7396942B2 (en) 2003-01-09 2008-07-08 Alcon, Inc. Dual function UV-absorbers for ophthalmic lens materials
US20040186241A1 (en) * 2003-03-20 2004-09-23 Gemert Barry Van Photochromic ocular devices
US20090157178A1 (en) 2005-09-23 2009-06-18 Norbert Hampp Intraocular lens
US20070077214A1 (en) 2005-10-03 2007-04-05 Biotechnology Research & Development Corporation Compositions comprising a uv-absorbing chromophore
WO2007140058A1 (en) * 2006-05-31 2007-12-06 Transitions Optical, Inc. Photochromic materials comprising metallocenyl groups
US20080090937A1 (en) 2006-10-13 2008-04-17 Alcon Manufacturing Ltd. Intraocular lenses with unique blue-violet cutoff and blue light transmission characteristics
WO2008048880A2 (en) * 2006-10-13 2008-04-24 Alcon, Inc. Intraocular lenses with unique blue-violet cutoff and blue light transmission characteristics
US20080242818A1 (en) 2007-03-05 2008-10-02 Benz Research And Development Corp. Light filters comprising a naturally occurring chromophore and derivatives thereof
US20100012889A1 (en) 2008-07-15 2010-01-21 Alcon, Inc. Uv-absorbers for ophthalmic lens materials

Also Published As

Publication number Publication date
CN102844683A (zh) 2012-12-26
JP2017128728A (ja) 2017-07-27
EP2553501A1 (en) 2013-02-06
JP6254135B2 (ja) 2017-12-27
US10029229B2 (en) 2018-07-24
JP2016094602A (ja) 2016-05-26
US20180297003A1 (en) 2018-10-18
AR080739A1 (es) 2012-05-02
ES2474094T3 (es) 2014-07-08
TW201202207A (en) 2012-01-16
AU2011235140B2 (en) 2015-01-15
CA2794284A1 (en) 2011-10-06
US10434489B2 (en) 2019-10-08
JP2013523961A (ja) 2013-06-17
RU2563640C2 (ru) 2015-09-20
US20150306562A1 (en) 2015-10-29
TWI583673B (zh) 2017-05-21
EP2553501B1 (en) 2014-05-14
CA2794284C (en) 2018-02-13
BR112012024962A2 (pt) 2016-07-12
AU2011235140A1 (en) 2012-09-27
US20110245818A1 (en) 2011-10-06
CN102844683B (zh) 2014-11-26
RU2012146774A (ru) 2014-05-10

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