WO2011116878A2 - Spectromètre, ainsi qu'appareil d'exploration doté de celui-ci - Google Patents

Spectromètre, ainsi qu'appareil d'exploration doté de celui-ci Download PDF

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Publication number
WO2011116878A2
WO2011116878A2 PCT/EP2011/001093 EP2011001093W WO2011116878A2 WO 2011116878 A2 WO2011116878 A2 WO 2011116878A2 EP 2011001093 W EP2011001093 W EP 2011001093W WO 2011116878 A2 WO2011116878 A2 WO 2011116878A2
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WO
WIPO (PCT)
Prior art keywords
examination
filter
detection means
light
image
Prior art date
Application number
PCT/EP2011/001093
Other languages
German (de)
English (en)
Other versions
WO2011116878A3 (fr
Inventor
Reimund Maier
Frank Zimmermann
Peter Lais
Jutta Eberhart
Sascha Seile
Herbert Gebhardt
Original Assignee
DüRR DENTAL AG
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Application filed by DüRR DENTAL AG filed Critical DüRR DENTAL AG
Publication of WO2011116878A2 publication Critical patent/WO2011116878A2/fr
Publication of WO2011116878A3 publication Critical patent/WO2011116878A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00174—Optical arrangements characterised by the viewing angles
    • A61B1/00177—Optical arrangements characterised by the viewing angles for 90 degrees side-viewing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0607—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements for annular illumination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
    • A61B1/0676—Endoscope light sources at distal tip of an endoscope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
    • A61B1/0684—Endoscope light sources using light emitting diodes [LED]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/201—Filters in the form of arrays
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/28—Interference filters
    • G02B5/285—Interference filters comprising deposited thin solid films
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/10—Cameras or camera modules comprising electronic image sensors; Control thereof for generating image signals from different wavelengths
    • H04N23/12—Cameras or camera modules comprising electronic image sensors; Control thereof for generating image signals from different wavelengths with one sensor only
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/555—Constructional details for picking-up images in sites, inaccessible due to their dimensions or hazardous conditions, e.g. endoscopes or borescopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6834—Means for maintaining contact with the body using vacuum
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N2209/00—Details of colour television systems
    • H04N2209/04—Picture signal generators
    • H04N2209/041—Picture signal generators using solid-state devices
    • H04N2209/042—Picture signal generators using solid-state devices having a single pick-up sensor
    • H04N2209/044—Picture signal generators using solid-state devices having a single pick-up sensor using sequential colour illumination

Definitions

  • the invention relates to a spectrometer according to the preamble of claim 1 and to an examination apparatus having such according to the preamble of claim 9.
  • the early diagnosis of cancer is an important area of medical and dental diagnostics.
  • tissue material of tissue areas to be checked is removed for further examination, which can be done in the case of mucous membranes such as the oral mucosa by means of a swab made with a more or less hard brush.
  • small tissue samples can be obtained with a scalpel or similar device.
  • dental handpiece cameras are already known on the market, which illuminate the tissue surface with UV light and examine the fluorescence emitted by the tissue regions.
  • Such a camera is described in WO 2005/110206 A.
  • the present invention is intended to open up the possibility, by using a compact device, to achieve a finer separation of light (sample light) thrown back from a sample into spectral components.
  • the invention provides a spectrometer with the features specified in claim 1 and an examination device according to claim 9.
  • the separating means splitting the sample light into spectral components is a multifilter which comprises a closely adjacent arrangement of bandpass filters. In this way, you can accommodate a large number of filters in a compact volume.
  • Such multifilters can be hertstellen as interference filter by vapor deposition of a permeable to all portions of the sample light substrate with dielectric or metallic layers, which differ in material and / or in thickness. Such evaporations can be precisely and well reproduced with the methods known from the vapor deposition of semiconductor elements. - 3 -
  • Such a multifilter can be designed pixel-like with small filter surfaces or have strip-shaped filter surfaces.
  • the filter surfaces can be adapted in their geometry to the geometry of the pixel arrangement of an image converter.
  • a fringe filter has the further advantage that it is well adapted to the geometry of conventional imagers in which individual detection elements (pixels) are arranged in matrix form.
  • Such image converter thus receives closely adjacent arranged in lines detection elements that can form a spectrometer combined with a strip filter.
  • This spectrometer consists of a multiplicity of detection elements with filters arranged in each case in front of a detection element or a group of detection elements, each of which transmits a narrow wavelength range.
  • a separate associated filter element of a multifilter designed as a matrix can be formed for each pixel of the image converter.
  • the substrate of the filter is provided with a thick coating which is suitable for the longest wavelength to be detected.
  • this layer is reduced by controlled removal in such a way that in the end each pixel of the filter corresponds to a different narrow transmission wave range.
  • the spectral distribution of the sample light is obtained for each image line (and thus for each pixel). From the data obtained in this way it is then possible to obtain a picture of the image for each examination wavelength of the strip filter
  • a Deflection unit which guides the sample light over the strip filter and the image converter, can be easily formed by a revolving mirror, a revolving prism or a circumferential plane-parallel plate.
  • the development of the invention according to claim 10 allows the determination of the spectral components of returning from the examination area sample light upon excitation of the examination area with different wavelengths wavelengths.
  • the different wavelengths can be realized in a very compact multi-wavelength excitation light source.
  • Sample light a high-pass edge filter whose edge is slightly above the longest wavelength, which is emitted by the multi-wavelength light source.
  • Stimulus is relatively weak.
  • the examination device can be left to work for a longer time at a given examination area in order to produce a low-noise image by temporally integrating the image signals.
  • the invention according to claim 13 a position stabilization of the examination device in the tissue area to be examined.
  • tissue areas are often to be examined, which have different orientation to an opening, through which an examination device can be introduced into the body cavity.
  • Claim 14 can be an examination head ', which contains the mechanical, optical and electronic Hauptento- nenteh angularly different from one
  • the examination device at substantially the same orientation of the handle portion for the study of differently oriented tissue areas
  • the development of the invention according to claim 16 is in view of the improvement of the signal / noise ratio of advantage.
  • An examination device makes it possible if necessary to deliver the image of an examination area, as would be the case if observed with a normal white-light camera.
  • FIG. 1 shows an axial section through an examination head of a medical or dental examination device for the early detection of cancer
  • Figure 2 is a schematic representation of the adjustment mechanism of a strip grid, which is used in the examination head according to Figure 1;
  • Figure 3 a schematic plan view of a section of the strip grid of Figure 2 and a
  • Section of an image converter which is arranged behind the strip grid, in enlarged
  • FIG. 4 an end view of the one shown in FIG.
  • FIG. 5 shows a schematic block diagram of the electronic components of the examination head according to FIG. 1;
  • FIG. 6 a schematic side view of a sub-frame Suchungskopfes, which has a hinge with
  • a handle portion is connected
  • FIG. 7 shows a plan view of the arrangement shown in FIG. 6.
  • FIG. 8 shows a schematic representation of a spectrometer which comprises an image converter, a strip grid and a beam deflection unit.
  • 10 denotes a tissue region
  • the tissue region has a surface 12 onto which an examination head, generally designated 14
  • This has a generally designated 16 housing with a cylindrical peripheral wall 18, a circular disc-shaped rear bottom wall 20 and a cylindrical end portion 22, which is made of transparent plastic material and is tightly inserted into the peripheral wall 18.
  • Pair of diametrically opposite LEDs the examination area 26 completely and preferably uniformly lit (possibly using a lens).
  • a pair of diametrically opposite LEDs 24 emits light with the same spectral distribution.
  • the emission wavelengths of the different pairs of light emitting diodes are different.
  • diodes 24-1 and 24-5 may be white light diodes while diodes 24-2 and 24-4 output 260 nm light, and light emitting diodes 24-4 and 24-8 emit 340-350 nm light.
  • diodes may be used which radiate in the ranges 405 to 414 nm, 540 nm, 578 nm and near infrared. In this case, either the number of pairs of diodes is increased accordingly, or only one will be available for each wavelength range
  • fluorescences of the following molecules can be excited: nicotinamide adenine dinucleotide [NAD (H)], flavin adenine dinucleotide [FAD (H)], porphyrins (e.g.
  • the examination head 14 has a central through-bore 28, in which a first lens 30 is seated. Escaping with this two more lenses 32, 34 are provided. The three lenses together form an objective 36. Between the lens 32 and the lens 34 there is provided a (wavelength-wise) high-pass edge filter 38 whose edge is laid so that the excitation light of the longest wavelength (in this case 350 nm) is just reliably retained.
  • An imager 40 which may be a known CCD component, is mounted on a carriage 42, which in turn is slidable on guide rods 44 carried by retaining eyes 46 fixedly connected to the peripheral wall 18 of the housing 16. about a threaded spindle 48, which is driven by a stepping motor 50, the carriage 42 and thus the image converter 40 along the axis of the lens 36 are moved to focus the image of the examination area 26 on the image converter 40.
  • the current position of the stepping motor 50 can be replaced by a
  • Positioner 52 is coupled, which is coupled to the stepper motor 50.
  • the top of the carriage 42 also carries two guide rails 54, 56 in which a strip filter 58 is guided.
  • the strip filter 58 is adjustable by a linear motor 60 perpendicular to the plane of Figure 1.
  • the position of the strip filter 58 is replaced by a
  • Positioner 62 controls that cooperates with the linear motor 60.
  • FIG. 2 shows the image converter 40 located behind the strip filter 58 in dashed lines. It can be seen that the strip filter 58 has a dimension, seen in the direction of movement, which is slightly larger than twice the dimension of the image converter 40 in the same direction.
  • the stripe filter 58 has two regions 58A and 58B which abut seamlessly and are each slightly larger than the window of the imager 40.
  • the memory filter region 58B is graphically raised against the memory filter region 58A by a punch. Physically, the two memory filter areas
  • each of these filter strips represents an interference filter for a wavelength range.
  • M is the number of columns
  • N is the number of lines of the image converter 40
  • J is the number of wavelength ranges
  • Pixels of the imager 40 are labeled 68 (, k).
  • the number of resolvable wavelength ranges is at a strip filter, as it is considered here, a maximum of M, ie the number of columns of the image converter 40.
  • M the number of columns of the image converter 40.
  • Suction channel 72 on a vacuum line 74.
  • small throttles 76 are each provided, which limit the suction flow. If the examination head 14 on the tissue surface put on, so builds up in the recesses 70
  • FIG. 5 shows the electronic part of the examination head, which is located in an external operating unit, partly also can be integrated into a handle which carries the examination body 14.
  • a processor is shown which may be a programmable computer with appropriate interfaces
  • the processor 88 receives via the line 87 the image signals provided by the image converter 20, via the line 84 of the output signal of the position sensor 50 and via the line 86, the output signal of the position sensor 62.
  • the processor 88 is a screen
  • Images of the examination area created by the processor 88 can be displayed both on the screen 90
  • the number of memory areas corresponds to the number of different filter strips
  • the examination device described above works like
  • the examination head 14 is placed on a point to be examined of the tissue area 10, wherein the
  • Vacuum line 74 is already subjected to vacuum.
  • the examination head 14 now sucks at the examination site.
  • the processor 88 the first UV light source is formed, which is formed by the light-emitting diodes 24-2 and 24-4 and radiates at 260 nm.
  • Image of the sub-area recorded This image comprises eight image strips each in the color of the filter strip in front of them.
  • the processor 88 now reads out the content of the image converter 40 in the usual way and stores this image in strips
  • Memory 96-j is a partial image of the examination area.
  • the linear motor 60 is then controlled by the processor 88 in such a way that it displaces the line filter 58 by one strip width. During translation, the imager becomes dead, ah it is reactivated.
  • Memory 96-j are stored. Each of the image memories now contains two adjacent image strips of the same color.
  • the processor 88 then controls the linear motor 60 again so that the strip filter 58 is offset by one strip width. Now you get from the different ones
  • Image strips images in a third color which are again stored in the corresponding memory areas 96-j.
  • Each of the image memories 96-j now contains three adjacent image strips of the corresponding color.
  • Image memory 96-j a complete image of the examination area in a color corresponding to the memory.
  • the processor 88 Upon completion of the measurement, when the stripe filter 58 is completely pushed over the imager 40, the processor 88 then begins to evaluate the fields stored in the memories 96-j.
  • This evaluation can be done in different directions: First, one can subject the subpictures to a picture manipulation by selecting the ones in the various memories
  • a concatenation may be a flush assembly into an overall image or else a multiplication of the individual pixel intensities Include images of different colors.
  • Detect and display 96-j stored data which gives a histogram representation of the spectrum for each image pixel. These spectra can then be visually evaluated or linked together again.
  • a concatenation can also include a difference formation and / or a quotient formation.
  • a white light image of the examination area can also be produced with the examination device described above.
  • the white light LEDs 24-1 and 24-5 are activated by the processor 88, and the reading of the image converter and the storage of the various image strips is the same as above
  • the spectral distribution of light at an image pixel or a range of adjacent image pixels may also be compared in processor 88 to comparable values of a known healthy tissue region (same patient or from a comparison database) to determine if a disease is present and how far, if any has progressed.
  • Figures 6 and 7 show how the inspection head 14 can be connected to a grip portion 98 which facilitates handling of the inspection head within a body cavity.
  • the examination head 14 runs cross-sectionally in cross section at its end remote from the objective and a joint plate 100 is pulled out of the lower generating line.
  • the handle portion 98 is tapered at the end facing the inspection head 14 and has a hinge plate 102 pulled out of the lower surface line.
  • the two hinge plates 100, 102 are interconnected by a uniaxial hinge 104. Due to this design of examination head 14 and handle portion 98, it is possible to adjust the examination head 14 inclined to the rear, as shown in dashed lines in Figure 6. In this way, the
  • the examination head 14 then the front portion of the oral cavity and lying on the inside of the jaw Examine gums. In the place represented by solid lines, the examination head is suitable for examining deeper parts of tissue lying in the oral cavity.
  • a deflection unit 106 can be rotatably mounted in order to allow a perpendicular to the axis of the handle portion 98 observation.
  • a deflecting mirror 108 which is arranged at 45 ° to the axis of the examination head, is accommodated, which deflects laterally sample light entering through a window 110 onto the axis of the deflection head 14.
  • FIG. 8 shows a compact spectrometer constructed in a simple manner, which comprises an image converter 40 and a strip filter 58 mounted flush thereon.
  • the strip filter has a number of filter strips 64-i which corresponds to the number of detector lines 66-j of the image converter 40 and if the distance of the filter strips 64 corresponds to that of the pixel columns 66, then the strip filter / image converter unit is irradiated with one
  • Sample light for each column of the imager a total electrical signal which corresponds to the intensity of the light in the lying before the image column filter strip wavelength range.
  • a narrow light beam 112 can be produced from the sample light using a diaphragm
  • Hide 114 and guide the light beam 112 over the strip filter 58. This can be done, for example, using a plane-parallel optical baffle 116 that is perpendicular to the plane of the drawing of FIG.
  • the spectral resolution of such a spectrometer is limited by the total number of image columns of the transducer. With a converter with 640 x 480 pixels one can thus dissolve maximally 640 wavelength intervals.
  • the range of visible light can thus be analyzed with a resolution of 1 nm. If you halve the number of light stripes so that each light stripe covers two columns of the light converter, you still have a resolution of 2 nm. If you choose the width of the filter stripes equal to ten times the distance of the image columns, a resolution of 10 nm remains.
  • the spectrometer of Figure 8 is thus characterized by a high sensitivity. It also has a very compact and mechanically simple construction. Of course, in the spectrometer of Figure 8
  • strip filter 58 may comprise only a single set of filter strips 60, for example only strip filter section 58A.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Multimedia (AREA)
  • Signal Processing (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Astronomy & Astrophysics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un appareil d'exploration, destiné à examiner optiquement des zones de tissu (10) à l'intérieur de cavités corporelles. Cet appareil comprend des diodes électroluminescentes (24) avec lesquelles la zone d'examen (26) peut être éclairée au choix avec de la lumière de différentes longueurs d'onde. La lumière de l'échantillon renvoyée par la zone d'examen (26) parvient à un convertisseur d'images (40) en traversant un objectif (36) et un filtre multiple (58), lequel comprend une pluralité de filtres interférentiels en forme de bandes. En réalisant un mouvement relatif entre le filtre multiple (58) et le convertisseur d'images (40), il est possible de déterminer des images par fluorescence de la zone d'examen (26) pour des plages spectrales prédéterminées. Par comparaison et/ou concaténation des images spectrales partielles, il est possible de différencier les zones de tissu malade des zones de tissu sain.
PCT/EP2011/001093 2010-03-23 2011-03-05 Spectromètre, ainsi qu'appareil d'exploration doté de celui-ci WO2011116878A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010012301.3 2010-03-23
DE102010012301A DE102010012301A1 (de) 2010-03-23 2010-03-23 Spektrometer sowie Untersuchungsgerät mit einem solchen

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110119024A (zh) * 2018-02-06 2019-08-13 雪力光纤有限公司 可视化模块和用于制造可视化模块的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005110206A1 (fr) 2004-05-16 2005-11-24 Dürr Dental GmbH & Co. KG Camera medicale

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0037529A1 (fr) * 1980-04-03 1981-10-14 Agfa-Gevaert AG Procédé de fabrication d'un photodétecteur avec un filtre à bandes de couleurs
US4615330A (en) * 1983-09-05 1986-10-07 Olympus Optical Co., Ltd. Noise suppressor for electronic endoscope
US4878113A (en) * 1987-08-11 1989-10-31 Olympus Optical Co., Ltd. Endoscope apparatus
JPH1198370A (ja) * 1997-07-24 1999-04-09 Nikon Corp 画像処理方法、画像処理装置及び制御手順を記憶する記憶媒体
US6667826B1 (en) * 2002-03-01 2003-12-23 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Chromatic modulator for high resolution CCD or APS devices
JP2007506485A (ja) * 2003-09-26 2007-03-22 タイダール フォトニクス，インク． カラー画像内視鏡システムに関する装置と方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005110206A1 (fr) 2004-05-16 2005-11-24 Dürr Dental GmbH & Co. KG Camera medicale

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110119024A (zh) * 2018-02-06 2019-08-13 雪力光纤有限公司 可视化模块和用于制造可视化模块的方法
US11006049B2 (en) * 2018-02-06 2021-05-11 Schölly Fiberoptic GmbH Visualization module and method for producing a visualization module
CN110119024B (zh) * 2018-02-06 2024-03-08 雪力光纤有限公司 可视化模块和用于制造可视化模块的方法

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