WO2011114122A1 - Dispositif d'injection amélioré - Google Patents
Dispositif d'injection amélioré Download PDFInfo
- Publication number
- WO2011114122A1 WO2011114122A1 PCT/GB2011/050316 GB2011050316W WO2011114122A1 WO 2011114122 A1 WO2011114122 A1 WO 2011114122A1 GB 2011050316 W GB2011050316 W GB 2011050316W WO 2011114122 A1 WO2011114122 A1 WO 2011114122A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- housing
- leadscrew
- cartridge
- clutch collar
- cartridge housing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
Definitions
- the present invention relates to an improved injection device, and more particularly to an injection device which provides for automatic medication delivery and for variable dose setting.
- WO2007063342 describes a generally pen-like syringe as shown in Figure 1 and which is suitable for use with a cartridge containing a medicament.
- the cartridge is held within a cartridge housing and is adapted to receive a needle (not shown) which pierces a rubber septum sealing a proximal end (with respect to a user's skin) of the cartridge.
- a cap 1 is provided for covering the cartridge housing 2 and cartridge, and any attached needle.
- the syringe incorporates a dose metering device provided by a dose knob 3 which is rotatable with respect to the main housing 4 to a position related to the dose of medication to be injected.
- Rotation of the cap stores energy in a torsion spring 5, which is prevented from unwinding by cooperating ratchet teeth.
- the user disengages the ratchet teeth by means of a sliding trigger 6 coupled to the outside of the main housing 4, resulting in the unwinding of the spring.
- This causes rotation of a drive gear 7 which is coupled to a plunger 8 via a quick pitch screw thread 9.
- the plunger is prevented from rotating by splines 10 fixed relative to the main housing 4 and which interact with recesses along the axial direction of the plunger, such that rotation of the gear results in axial movement of the plunger 8 through the main housing.
- a cap 1 1 rotatably mounted on the end of the plunger 8 acts on a "bung" 12 of the cartridge 13, driving medicament 14 from the cartridge, through an attached needle, as the plunger moves in the direction of arrow A.
- a user who may be an end user or patient or a device assembler, receives the device with the plunger 8 in a given position with respect to the housing. Whatever this starting position of the plunger, it will probably need to be moved axially with respect to the housing 4 in order to align the cap 1 1 of the plunger with the bung 12 when the cartridge and cartridge housing are attached to the housing. This also applies when a user wishes to replace a used cartridge with a new cartridge. Adjustment of the plunger position is facilitated by screwing the plunger into, or out of, the housing. A clutch mechanism is provided for this purpose.
- the cartridge housing continues to be screwed onto the housing and to move towards the housing. This exerts a potentially large force on the cartridge bung, in turn exerting a force on the inside of the septum 15, because the cartridge is closed and a pressure will be built up in the medicament. This may lead the septum to burst, or at the very least cause medicament to be unnecessarily driven out of the cartridge when a needle is being attached.
- WO 2009/049885 describes an injection device with reset of the piston rod caused by cartridge exchange.
- EP0688571 and EP0450905 also describe injection devices.
- an injection device comprising a main housing defining a first screw thread and a plunger comprising a leadscrew and a cap rotatably attached to the leadscrew such that, in use, the cap engages a bung of a cartridge containing medicament.
- a drive gear is mounted within the housing and the drive gear engages with a screw thread on said leadscrew such that rotation of the drive gear around the leadscrew drives the plunger axially through the housing when the leadscrew is locked against rotation with respect to the housing.
- a cartridge housing is also provided for holding a cartridge containing medicament. This housing defines a second screw thread for engagement with said first screw thread in order to secure the cartridge housing to the main housing.
- the device further comprises a locking mechanism which is actuated when the cartridge housing is secured to the main housing and which locks the leadscrew against rotation with respect to the housing.
- Cooperating features are provided for allowing the leadscrew to rotate relative to the cartridge housing during attachment of the cartridge housing to the main housing whilst allowing relative rotation of the engaged first and second screw threads to cause rotation of the leadscrew relative to the housing and hence axial movement of the leadscrew into the housing.
- the pitch of the thread provided on the leadscrew is substantially the same as the pitch of said first and second screw threads. This pitch arrangement, together with the cooperating features, enables the leadscrew and cartridge housing to move substantially at the same axial speed when attaching the cartridge housing to the main housing.
- Embodiments of the present invention may allow the injection device to be assembled without exerting undesirable pressure on the cartridge before firing the injection device.
- the locking mechanism may comprise a clutch collar engaged with said leadscrew so as to rotate with the leadscrew but to be axially moveable relative to the leadscrew.
- Said cooperating features may comprise one or more axially extending features defined on the clutch collar and one or more axially extending features defined on the cartridge housing, these features mating during attachment of the cartridge housing to the main housing so as to cause the clutch collar and the leadscrew to rotate with the cartridge housing. These features on the clutch collar and the cartridge housing are splines.
- a resilient coupling may be provided between said clutch collar and said main housing and which exerts a force on the clutch collar so as to push the clutch collar away from the main housing.
- the injection device may comprise a bush coupling the clutch collar to the leadscrew such that the bush and the clutch collar rotate together but can move axially with respect to one another.
- the bush may comprise one or more splines, with the leadscrew defining one or more axially extending slots, each said slot receiving a spline of the bush.
- Figure 1 shows a horizontal cross-section through a prior art injector pen and a detail of the same horizontal cross-section
- Figure 2 is a perspective view of a plunger of the device of Figure 1 , interacting with a medicament containing cartridge;
- Figure 3 shows a partial cut-away view of an improved injector pen
- Figure 4 shows a further partial cut-away view of the injector pen of Figure 3;
- Figure 5 is a perspective view of a clutch assembly of the injector pen of Figure 3 and 4;
- Figure 6 shows a horizontal cross-section through part of the improved injector pen
- Figure 7 shows an exploded view of the improved injector pen.
- FIGS 3 to 7 show an injection device having a main housing 4 which contains a dose setting mechanism and a firing mechanism, which mechanisms are substantially as described in WO2007063342.
- a dose knob 3 is provided at a proximal end of the device and which is rotatable with respect to the main housing 4.
- Rotation of the cap stores energy in a torsion spring 5, which is prevented from unwinding by cooperating ratchet teeth 16 formed on a drive gear 7 and a sliding trigger 6.
- the user disengages the ratchet teeth 16 by means of the sliding trigger 6, which is coupled to the outside of the main housing, resulting in the unwinding of the spring.
- the plunger 8 comprises a leadscrew 19 and a cap 1 1 and protrudes from the main housing 4 to a variable extent.
- the leadscrew 19 has a screw thread 9 provided along the length of its outer surface. Recesses 18 are formed along the length of the leadscrew 19.
- the screw thread 9 provided on the leadscrew 19 engages with a complimentary screw thread formed on an inner surface of the drive gear 7.
- a screw thread 20 is provided around an external surface of a main housing collar 21 , which snap fits onto the main housing .
- the pitch of this screw thread 20 is substantially the same as the pitch of the screw thread 9 provided on the leadscrew 19.
- a clutch assembly 22 consists of a locking bush 23, a clutch collar 24 and a spring 25.
- the clutch assembly 22 is telescopically located within the main housing 4, such that a part of the locking bush protrudes from the main housing.
- the spring 25 biases the locking bush 23 in an extended state relative to the clutch collar 24.
- a further spring 29 acts between the trigger slide 6 and the locking bush 23, biasing the whole clutch assembly in an extended state relative to the main housing in the absence of any external force.
- Splines 17 are provided on the inside of the clutch assembly 22 to engage with the recesses 18 along the length of the leadscrew 19.
- Spline teeth 26 are provided on the outside of the clutch assembly 22 at a distal end thereof.
- a cartridge housing 2 is provided for receiving a disposable medication filled cartridge 13 (as illustrated in Figure 2).
- the cartridge has a movable rubber bung 12 towards the distal end of the cartridge, with the proximal end containing a septum 15 being arranged to receive a disposable needle.
- the septum 15 is self-sealing to allow it to close when a needle is removed.
- An internal screw thread 27 is provided at the distal end of the cartridge housing.
- Spline teeth 28 are provided on the inside of the cartridge housing 2 adjacent to the internal screw thread 27 of the cartridge housing 2.
- the section of the cartridge housing with the internal thread 27 has a larger internal diameter than the section of the cartridge housing with the spline teeth 28 and is located closer to the distal end of the cartridge housing.
- a user can rotate the leadscrew 19 by hand to adjust the distance it protrudes from the main housing 4.
- the leadscrew 19 can also be pushed into the housing by applying a force on the cap 1 1 of the plunger in axial direction (the cap rotates relative to the leadscrew).
- a user will wind out the leadscrew to a point beyond where it needs to be in order to engage a bung of a cartridge to be attached . The attachment process then continues as described hereinbelow.
- the cartridge housing will continue to apply a force on the plunger during this phase of the attachment process.
- the spline teeth 28 of the cartridge housing engage with the spline teeth 26 of the clutch collar.
- the spring 25 inside the clutch assembly allows for smooth engaging of the spline teeth of the clutch collar with the cartridge housing.
- the spline teeth of the cartridge housing and the clutch collar engage, they will lock the rotation of the cartridge housing 2 and the clutch assembly 22 together, while accommodating varying compression of the cartridge housing and the main housing. Since splines 17 are provided on the inside of the clutch assembly to engage with the recesses 18 along the length of the leadscrew, the leadscrew must rotate together with the clutch assembly and hence with the cartridge housing.
- the cartridge housing 2 is arranged to be rotated another turn or so until it is screwed tight onto the main housing.
- the leadscrew rotates with the cartridge housing. Since the pitch of the screw thread of the cartridge housing is the same as the pitch of the screw thread of the leadscrew, the cartridge housing and the plunger will not only rotate together, but they will also move together in the axial direction. This synchronisation of motions prevents the cap 1 1 from exerting any significant force on the bung 12 within the cartridge. This in turn prevents any significant force being applied to the septum 13 and the risk of the septum rupturing is greatly reduced. It will be appreciated by the person of skill in the art that various modifications may be made to the above described embodiment without departing from the scope of the present invention.
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
L'invention concerne un dispositif d'injection comprenant un corps principal (4) définissant un premier filetage (20) et un piston composé d'une vis-mère (19) et d'un capuchon (11) attaché à la vis-mère de façon à pouvoir tourner, de façon à ce que lors de l'utilisation, le capuchon s'engage sur le bouchon d'une cartouche contenant un médicament. Une roue dentée d'entraînement est montée à l'intérieur du logement de façon à pouvoir tourner autour de la vis-mère pour entraîner le piston axialement au travers du logement lorsque la vis-mère est bloquée pour empêcher la rotation par rapport au logement. Le dispositif comporte aussi un logement de cartouche (2) pour maintenir une cartouche contenant un médicament. Ce logement définit un deuxième filetage (27) pour l'engagement dudit premier filetage afin de fixer le logement de cartouche au logement principal. Le dispositif comprend de plus un mécanisme de verrouillage (26, 28) qui est actionné lorsque le logement de cartouche est fixé au logement principal et qui la vis-mère pour empêcher la rotation par rapport au logement. Des fonctionnalités homologues permettent à la vis-mère de tourner par rapport au logement de cartouche lors de la fixation de celui-ci au logement principal tout en permettant à la rotation relative des premier et deuxième filetages engagés de provoquer la rotation de la vis-mère par rapport au logement et donc le mouvement axial de la vis-mère dans le logement.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201004626A GB201004626D0 (en) | 2010-03-19 | 2010-03-19 | Improved injection device |
GB1004626.6 | 2010-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011114122A1 true WO2011114122A1 (fr) | 2011-09-22 |
Family
ID=42228006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2011/050316 WO2011114122A1 (fr) | 2010-03-19 | 2011-02-17 | Dispositif d'injection amélioré |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB201004626D0 (fr) |
WO (1) | WO2011114122A1 (fr) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013078078A1 (fr) * | 2011-11-22 | 2013-05-30 | West Pharmaceutical Services, Inc. | Ensemble entraînement et engrenage linéaire |
GB2509348A (en) * | 2013-09-10 | 2014-07-02 | Owen Mumford Ltd | Leak prevention in torsion-spring cartridge injector |
WO2014166912A1 (fr) * | 2013-04-10 | 2014-10-16 | Sanofi | Dispositif d'injection |
WO2014166903A1 (fr) * | 2013-04-10 | 2014-10-16 | Sanofi | Mécanisme d'entraînement d'un dispositif d'administration de médicament |
GB2516071A (en) * | 2013-07-10 | 2015-01-14 | Owen Mumford Ltd | Control of plunger position in an injection device |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0450905A1 (fr) | 1990-04-04 | 1991-10-09 | Eli Lilly And Company | Seringue à dosage indiqué |
EP0688571A1 (fr) | 1994-06-22 | 1995-12-27 | Becton, Dickinson and Company | Crayon à injection avec connexion rapide |
WO1997010864A1 (fr) * | 1995-09-19 | 1997-03-27 | Becton Dickinson And Company | Injecteur de stylo dote d'un mecanisme de chargement de cartouche |
WO2001010484A1 (fr) * | 1999-08-05 | 2001-02-15 | Becton, Dickinson And Company | Stylo d'administration de produits medicaux |
WO2007063342A1 (fr) | 2005-12-02 | 2007-06-07 | Owen Mumford Limited | Méthode d’injection et appareil |
WO2009049885A1 (fr) | 2007-10-17 | 2009-04-23 | Haselmeier Gmbh | Appareil d'injection avec rappel de la tige de piston déclenché par un changement de cartouche |
-
2010
- 2010-03-19 GB GB201004626A patent/GB201004626D0/en not_active Ceased
-
2011
- 2011-02-17 WO PCT/GB2011/050316 patent/WO2011114122A1/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0450905A1 (fr) | 1990-04-04 | 1991-10-09 | Eli Lilly And Company | Seringue à dosage indiqué |
EP0688571A1 (fr) | 1994-06-22 | 1995-12-27 | Becton, Dickinson and Company | Crayon à injection avec connexion rapide |
WO1997010864A1 (fr) * | 1995-09-19 | 1997-03-27 | Becton Dickinson And Company | Injecteur de stylo dote d'un mecanisme de chargement de cartouche |
WO2001010484A1 (fr) * | 1999-08-05 | 2001-02-15 | Becton, Dickinson And Company | Stylo d'administration de produits medicaux |
WO2007063342A1 (fr) | 2005-12-02 | 2007-06-07 | Owen Mumford Limited | Méthode d’injection et appareil |
WO2009049885A1 (fr) | 2007-10-17 | 2009-04-23 | Haselmeier Gmbh | Appareil d'injection avec rappel de la tige de piston déclenché par un changement de cartouche |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013078078A1 (fr) * | 2011-11-22 | 2013-05-30 | West Pharmaceutical Services, Inc. | Ensemble entraînement et engrenage linéaire |
US11291774B2 (en) | 2013-04-10 | 2022-04-05 | Sanofi | Drive mechanism for a drug delivery device |
WO2014166912A1 (fr) * | 2013-04-10 | 2014-10-16 | Sanofi | Dispositif d'injection |
WO2014166903A1 (fr) * | 2013-04-10 | 2014-10-16 | Sanofi | Mécanisme d'entraînement d'un dispositif d'administration de médicament |
US10130772B2 (en) | 2013-04-10 | 2018-11-20 | Sanofi | Injection device |
US9517309B2 (en) | 2013-07-10 | 2016-12-13 | Owen Mumford Ltd. | Control of plunger position in an injection device |
GB2516071A (en) * | 2013-07-10 | 2015-01-14 | Owen Mumford Ltd | Control of plunger position in an injection device |
WO2015004428A1 (fr) * | 2013-07-10 | 2015-01-15 | Owen Mumford Ltd | Contrôle de position de piston dans un dispositif d'injection |
GB2516071B (en) * | 2013-07-10 | 2016-01-06 | Owen Mumford Ltd | Control of plunger position in an injection device |
WO2015036729A1 (fr) * | 2013-09-10 | 2015-03-19 | Owen Mumford Limited | Rétraction de piston pour la prévention de fuite dans un dispositif d'injection |
CN105530971A (zh) * | 2013-09-10 | 2016-04-27 | 欧文蒙福德有限公司 | 用于在注射装置中防止泄漏的柱塞缩回 |
US9808581B2 (en) | 2013-09-10 | 2017-11-07 | Owen Mumford Limited | Plunger retraction for leak prevention in injection device |
GB2509348B (en) * | 2013-09-10 | 2016-03-30 | Owen Mumford Ltd | Leak prevention in injection device |
GB2509348A (en) * | 2013-09-10 | 2014-07-02 | Owen Mumford Ltd | Leak prevention in torsion-spring cartridge injector |
Also Published As
Publication number | Publication date |
---|---|
GB201004626D0 (en) | 2010-05-05 |
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