WO2011110842A3 - Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome - Google Patents
Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome Download PDFInfo
- Publication number
- WO2011110842A3 WO2011110842A3 PCT/GB2011/050454 GB2011050454W WO2011110842A3 WO 2011110842 A3 WO2011110842 A3 WO 2011110842A3 GB 2011050454 W GB2011050454 W GB 2011050454W WO 2011110842 A3 WO2011110842 A3 WO 2011110842A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- glucose metabolism
- birt
- hogg
- treatment
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 7
- 230000004153 glucose metabolism Effects 0.000 title abstract 5
- 208000033929 Birt-Hogg-Dubé syndrome Diseases 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- VRYALKFFQXWPIH-PBXRRBTRSA-N (3r,4s,5r)-3,4,5,6-tetrahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)CC=O VRYALKFFQXWPIH-PBXRRBTRSA-N 0.000 abstract 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 abstract 1
- PMMURAAUARKVCB-UHFFFAOYSA-N alpha-D-ara-dHexp Natural products OCC1OC(O)CC(O)C1O PMMURAAUARKVCB-UHFFFAOYSA-N 0.000 abstract 1
- 230000002414 glycolytic effect Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11709454A EP2544678A2 (en) | 2010-03-09 | 2011-03-08 | Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dubé syndrome |
GB1218050.1A GB2491539A (en) | 2010-03-09 | 2011-03-08 | Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1003894.1 | 2010-03-09 | ||
GB1003894A GB2478556A (en) | 2010-03-09 | 2010-03-09 | A composition for use in the treatment of Birt-Hogg-Dubô sydrome |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011110842A2 WO2011110842A2 (en) | 2011-09-15 |
WO2011110842A3 true WO2011110842A3 (en) | 2012-05-10 |
Family
ID=42136701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2011/050454 WO2011110842A2 (en) | 2010-03-09 | 2011-03-08 | Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2544678A2 (en) |
GB (2) | GB2478556A (en) |
WO (1) | WO2011110842A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021007499A1 (en) * | 2019-07-11 | 2021-01-14 | Emory University | Combination therapies for managing cancer |
WO2021251842A1 (en) * | 2020-06-08 | 2021-12-16 | Qatar Foundation For Education, Science And Community Development | Targeting of lactate dehydrogenase c, methods of preparing same, and methods of using same in combination with anti-cancer treatments |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004062604A2 (en) * | 2003-01-10 | 2004-07-29 | Threshold Pharmaceuticals, Inc. | Treatment of cancer with 2-deoxyglucose |
WO2004064734A2 (en) * | 2003-01-17 | 2004-08-05 | Threshold Pharmaceuticals, Inc. | Combination therapies for the treatment of cancer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670330B1 (en) * | 2000-05-01 | 2003-12-30 | Theodore J. Lampidis | Cancer chemotherapy with 2-deoxy-D-glucose |
JP2010520289A (en) * | 2007-03-07 | 2010-06-10 | アブラクシス バイオサイエンス, エルエルシー | Nanoparticles containing rapamycin and albumin as anticancer agents |
KR20110090911A (en) * | 2008-10-31 | 2011-08-10 | 노파르티스 아게 | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
-
2010
- 2010-03-09 GB GB1003894A patent/GB2478556A/en not_active Withdrawn
-
2011
- 2011-03-08 WO PCT/GB2011/050454 patent/WO2011110842A2/en active Application Filing
- 2011-03-08 EP EP11709454A patent/EP2544678A2/en not_active Withdrawn
- 2011-03-08 GB GB1218050.1A patent/GB2491539A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004062604A2 (en) * | 2003-01-10 | 2004-07-29 | Threshold Pharmaceuticals, Inc. | Treatment of cancer with 2-deoxyglucose |
WO2004064734A2 (en) * | 2003-01-17 | 2004-08-05 | Threshold Pharmaceuticals, Inc. | Combination therapies for the treatment of cancer |
Non-Patent Citations (4)
Title |
---|
H PELICANO ET AL: "Glycolysis inhibition for anticancer treatment", ONCOGENE, vol. 25, no. 34, 7 August 2006 (2006-08-07), pages 4633 - 4646, XP055009657, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1209597 * |
JACQUELINE VUKY ET AL: "Phase II trial of imatinib (Gleevec(R)) in patients with metastatic renal cell carcinoma", INVESTIGATIONAL NEW DRUGS ; THE JOURNAL OF NEW ANTICANCER AGENTS, KLUWER ACADEMIC PUBLISHERS, BO, vol. 24, no. 1, 1 January 2006 (2006-01-01), pages 85 - 88, XP019206130, ISSN: 1573-0646, DOI: 10.1007/S10637-005-4543-Z * |
W. MARSTON LINEHAN ET AL: "Molecular Diagnosis and Therapy of Kidney Cancer*", ANNUAL REVIEW OF MEDICINE, vol. 61, no. 1, 1 February 2010 (2010-02-01), pages 329 - 343, XP055021613, ISSN: 0066-4219, DOI: 10.1146/annurev.med.042808.171650 * |
YANG ET AL: "The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dube gene pathway", CANCER GENETICS AND CYTOGENETICS, ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, vol. 180, no. 2, 16 January 2008 (2008-01-16), pages 100 - 109, XP022422140, ISSN: 0165-4608, DOI: 10.1016/J.CANCERGENCYTO.2007.10.010 * |
Also Published As
Publication number | Publication date |
---|---|
GB2478556A (en) | 2011-09-14 |
WO2011110842A2 (en) | 2011-09-15 |
GB2491539A (en) | 2012-12-05 |
GB201003894D0 (en) | 2010-04-21 |
EP2544678A2 (en) | 2013-01-16 |
GB201218050D0 (en) | 2012-11-21 |
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