GB2491539A - Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome - Google Patents

Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome Download PDF

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Publication number
GB2491539A
GB2491539A GB1218050.1A GB201218050A GB2491539A GB 2491539 A GB2491539 A GB 2491539A GB 201218050 A GB201218050 A GB 201218050A GB 2491539 A GB2491539 A GB 2491539A
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GB
United Kingdom
Prior art keywords
glucose metabolism
birt
hogg
treatment
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1218050.1A
Other versions
GB201218050D0 (en
Inventor
Andrew Tee
Keith Baar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myrovlytis Technology Ventures Ltd
Original Assignee
Myrovlytis Technology Ventures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myrovlytis Technology Ventures Ltd filed Critical Myrovlytis Technology Ventures Ltd
Publication of GB201218050D0 publication Critical patent/GB201218050D0/en
Publication of GB2491539A publication Critical patent/GB2491539A/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A composition comprising an inhibitor of glucose metabolism for use in the treatment of Birt-Hogg-Dubé syndrome. The inhibitor of glucose metabolism may be a glycolytic inhibitor. The inhibitor of glucose metabolism may be an inhibitor of pyruvate metabolism. Suitable inhibitors of glucose metabolism include 2-deoxy-D- glucose or a pharmaceutically acceptable salt or solvate thereof or oxamate or a pharmaceutically acceptable salt or solvate thereof.
GB1218050.1A 2010-03-09 2011-03-08 Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome Withdrawn GB2491539A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1003894A GB2478556A (en) 2010-03-09 2010-03-09 A composition for use in the treatment of Birt-Hogg-Dubô sydrome
PCT/GB2011/050454 WO2011110842A2 (en) 2010-03-09 2011-03-08 Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome

Publications (2)

Publication Number Publication Date
GB201218050D0 GB201218050D0 (en) 2012-11-21
GB2491539A true GB2491539A (en) 2012-12-05

Family

ID=42136701

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1003894A Withdrawn GB2478556A (en) 2010-03-09 2010-03-09 A composition for use in the treatment of Birt-Hogg-Dubô sydrome
GB1218050.1A Withdrawn GB2491539A (en) 2010-03-09 2011-03-08 Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1003894A Withdrawn GB2478556A (en) 2010-03-09 2010-03-09 A composition for use in the treatment of Birt-Hogg-Dubô sydrome

Country Status (3)

Country Link
EP (1) EP2544678A2 (en)
GB (2) GB2478556A (en)
WO (1) WO2011110842A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021007499A1 (en) * 2019-07-11 2021-01-14 Emory University Combination therapies for managing cancer
WO2021251842A1 (en) * 2020-06-08 2021-12-16 Qatar Foundation For Education, Science And Community Development Targeting of lactate dehydrogenase c, methods of preparing same, and methods of using same in combination with anti-cancer treatments

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004062604A2 (en) * 2003-01-10 2004-07-29 Threshold Pharmaceuticals, Inc. Treatment of cancer with 2-deoxyglucose
WO2004064734A2 (en) * 2003-01-17 2004-08-05 Threshold Pharmaceuticals, Inc. Combination therapies for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670330B1 (en) * 2000-05-01 2003-12-30 Theodore J. Lampidis Cancer chemotherapy with 2-deoxy-D-glucose
PT2131821T (en) * 2007-03-07 2018-10-10 Abraxis Bioscience Llc Nanoparticle comprising rapamycin and albumin as anticancer agent
JP2012506898A (en) * 2008-10-31 2012-03-22 ノバルティス アーゲー Combination of phosphatidylinositol-3-kinase (PI3K) inhibitor and mTOR inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004062604A2 (en) * 2003-01-10 2004-07-29 Threshold Pharmaceuticals, Inc. Treatment of cancer with 2-deoxyglucose
WO2004064734A2 (en) * 2003-01-17 2004-08-05 Threshold Pharmaceuticals, Inc. Combination therapies for the treatment of cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANNUAL REVIEW OF MEDICINE, Vol. 61, 2010, W. MARSTON LINEHAN ET AL: "Molecular Diagnosis and Therapy of Kidney Cancer", Pages 329-343 *
CANCER GENETICS AND CYTOGENETICS, ELSEVIER SCIENECE PUBLISHING, Vol. 180, 2008, YANG ET AL: "The UOK 257 cell line: a novel model for studies of the human....", Pages 100-109 *
INVESTIGATIONAL NEW DRUGS ; THE JOURNAL OF NEW ANTICANCER AGENTS, KLUWER ACADEMIC PUBLISHERS, Vol. 24, 2006, JACQUELINE VUKY ET AL: "Phase II trial of imatinib (Gleevec(R)) in patients with metastatic renal cell carcinoma", Pages 85-88 *
ONCOGENE, Vol. 25, 2006, H PELICANO ET AL: "Glycolysis inhibition for anticancer treatment", Pages 4633-4646 *

Also Published As

Publication number Publication date
GB201003894D0 (en) 2010-04-21
GB2478556A (en) 2011-09-14
WO2011110842A3 (en) 2012-05-10
WO2011110842A2 (en) 2011-09-15
EP2544678A2 (en) 2013-01-16
GB201218050D0 (en) 2012-11-21

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)