WO2011107753A1 - Agent antimicrobien - Google Patents

Agent antimicrobien Download PDF

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Publication number
WO2011107753A1
WO2011107753A1 PCT/GB2011/000312 GB2011000312W WO2011107753A1 WO 2011107753 A1 WO2011107753 A1 WO 2011107753A1 GB 2011000312 W GB2011000312 W GB 2011000312W WO 2011107753 A1 WO2011107753 A1 WO 2011107753A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
acidulant
salts
composition
antioxidant
Prior art date
Application number
PCT/GB2011/000312
Other languages
English (en)
Inventor
Jeffrey Ian Dodd
Original Assignee
Natural Biotechnology Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natural Biotechnology Sprl filed Critical Natural Biotechnology Sprl
Publication of WO2011107753A1 publication Critical patent/WO2011107753A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances

Definitions

  • the present invention relates to a novel antimicrobial composition and to novel methods related thereto.
  • the invention relates a novel composition formulated using natural derived intermediates suitable for general purpose ((working surfaces, packing cases ⁇ plastic or mild steel 316)) and clean-in-place (CEP) cleaning and decontamination, extending the storage life of fresh produce, such as fruit, vegetables, poultry meat and fish.
  • general purpose (working surfaces, packing cases ⁇ plastic or mild steel 316)
  • CEP clean-in-place
  • composition and the method of the invention prevents or mitigates the spoilage of such fresh produce.
  • the suitable packaging as described above need to be washed in a suitable medium so as to decontaminate the packaging, removing or killing any microorganisms that are deposited on the surfaces thereof.
  • microorganisms include, inter alia, Escherichia coli, Salmonella typhi murium, staphylococcus aureus, Enterococcus hirae. Listeria monocytogenes. Bacillus cereus, Candida Albicans, Aspergillus niger, Pseudomonas Aeruginosa and Campylobacter.
  • the decontaminant comprises an acidulant.
  • the acidulant is selected from those that will reduce the pH to at least about 3 or less.
  • the acidulant will reduce the pH to at least about 2.3 or less, preferably 2 or less, preferably to about 1.8 or less and most preferably to about 1.4 or less.
  • the amount of concentration of decontaminant present may vary depending upon, inter alia, the nature of the decontaminant, the level of spoilage on the surface, e.g. packaging, being treated.
  • the amount of decontaminant/acidulant, present may be from about from about 0.1% to about 25% (w/v), preferably from about 0.1% to about 6% (w/v), preferably from about 0.1% to about 4% (w/v), preferably from about 1% to about 4% (w/v).
  • the acidulant is a modified acidified salt.
  • the acidified salt may be acidified sodium chloride, e.g. bisulphate of soda/ sodium bisulphate/ sodium hydrogen sulphate (NaHS0 4 ).
  • the modified acidified salt may include an antioxidant reducing agent, such as ascorbic acid.
  • the antioxidant/reducing agent will be a free radical scavenger which can prevent oxidation by altering the REDOX potential of the system and can reduce undesirable oxidative products.
  • antioxidants/reducing agents include, but shall not be limited to, ascorbic acid (vitamin C) and especially salts thereof, such as alkali metal salts, e.g. sodium ascorbate; erythorbic acid and especially salts thereof, such as alkali metal salts, e.g.
  • antioxidant carboxylic acids such as a rosmarinic acid ([[3-(3,4- dihydroxyphenyl)-l-oxo-2E-propenyl]oxy]-3,4-dihydroxy- benzenepropanoic acid), and optionally salts thereof, such as alkali metal salts; tannic acid, and optionally salts thereof, such as alkali metal salts.
  • the aforementioned antioxidants/reducing agents such as, ascorbic acid, act as a reducing agent which functions as a free radical scavenger preventing oxidation by altering the REDOX potential of the system and reduces undesirable oxidative products.
  • the amount of antioxidant/reducing agent may vary and may be from about 0.25% (w/v) to about 10% (w/v), preferably from about 0.5% (w/v) to about 5% (w/v), more preferably from about 1% (w/v) to about 2% (w/v). According to one aspect of the invention we provide a method as herein before described wherein the pre-wash pre-dipping step is present.
  • the antioxidant/reducing agent such as ascorbic acid
  • a preferred diluent comprises one or more of ; flavouring and preservative agents, such as, succinic acid, and optionally salts thereof, and citric acid, and optionally salts thereof; a surfactant, such as, an alkyl (alkyl CI to 20, preferably C8) glucoside; and a pH regulator, such as, lactic acid, and optionally salts thereof.
  • the diluent comprises a blend of two or more of a flavouring and preservative agent(s), a surfactant and a pH regulator.
  • the diluent comprises a blend of two or more of succinic acid, citric acid, an alkyl glucoside and lactic acid, and optionally salts thereof, and more preferably a blend comprising each of succinic acid, citric acid, an alkyl glucoside, lactic acid, and optionally salts thereof, and tannic acid, and optionally salts thereof.
  • the modified bisulphate of soda may function as an acidulant and thereby has a denaturing effect on microorganisms, for example, by reducing the pH to below the level at which is required to inactivate microorganisms.
  • the decontaminant is one which can reduce or better "kill" those bacterium/micro-organisms common to fruit and vegetables, fish meat and poultry which are detrimental to health.
  • Such a decontaminant will achieve a minimum Log Reduction of 5 against both Gram+ and Gram- organisms.
  • the microbiological analysis will use the methodology as prescribed by ENBS 1276: 1997, available from BSI in the UK.
  • the term "high concentration" when used in connection with the pre-washing according to the present invention would generally be understood by the person skilled in the art. However, a high concentration may be from about 2 to about 10% (w/v), preferably 2.5 to about 5% (w/v).
  • the term "low concentration” when used in connection with the main wash according to the present invention would generally be understood by the person skilled in the art. However, a low concentration may be from about 0.1 to about 1.5% (w/v), preferably 0.5 to about l% (w/v).
  • the method of the invention comprises the simultaneous treatment of a surface with a decontaminant formulated using naturally derived intermediates formulated in such a way to maximise a quick effective and efficient decontamination process.
  • the method of decontamination is desirably carried out quickly and efficiently without adverse effects to the integrity of the fresh food produce.
  • the decontaminant may be present in a solution and the produce may be sprayed or wiped with the solution to achieve the desired effect of decontamination.
  • the surface e.g. packaging, may be dipped in the decontaminant solution to achieve the desired effect.
  • the method of the invention as hereinbefore described may comprise the treatment, i.e. decontamination, of a variety of surfaces.
  • the method of decontaminant may comprise, inter alia, food related cleaning applications (clean-in-place (CIP), floors, walls, mixing vessels, pipe work, work tops, etc.; transport, e.g. vessels used for transporting food produce; packing cases (plastics, stainless steel, etc); decontamination of fishing vessels, etc.
  • CIP food related cleaning applications
  • transport e.g. vessels used for transporting food produce
  • packing cases plastics, stainless steel, etc
  • decontamination of fishing vessels etc.
  • the acidulant is a modified acidified salt as hereinbefore described.
  • the modified acidified salt in the composition of the invention may be a mixture of bisulphate of soda and an antioxidant reducing agent, such as ascorbic acid.
  • antioxidants/reducing agents which may be included in the composition of the invention, are one or more of ascorbic acid (vitamin C) and especially salts thereof, such as alkali metal salts, e.g. sodium ascorbate; erythorbic acid and especially salts thereof, such as alkali metal salts, e.g. sodium erythorbate; phenolic antioxidant carboxylic acids, such as a rosmarinic acid ([[3-(3,4-dihydroxyphenyl)-l-oxo-2E-propenyl]oxy]-3,-dihydroxy- benzenepropanoic acid) and optionally salts thereof, such as alkali metal salts.
  • vitamin C ascorbic acid
  • salts thereof such as alkali metal salts, e.g. sodium ascorbate
  • erythorbic acid and especially salts thereof, such as alkali metal salts, e.g. sodium erythorbate
  • phenolic antioxidant carboxylic acids such as a
  • the antioxidant/reducing agent such as ascorbic acid
  • a preferred diluent comprises one or more of flavouring and preservative agents, such as, citric acid, and optionally salts thereof, or succinic acid, and optionally salts thereof; a surfactant, such as, an alkyl (alkyl CI to 20, preferably C8) glucoside; and a pH regulator, such as, lactic acid, and optionally salts thereof.
  • the diluent comprises a blend of two or more of a flavouring and preservative agent(s), a surfactant and a pH regulator.
  • the diluent comprises a blend of two or more of succinic acid, citric acid, an alkyl glucoside and lactic acid, and optionally salts thereof, and more preferably a blend comprising each of succinic acid, citric acid, an alkyl glucoside and lactic acid, and optionally salts thereof.
  • a kit suitable for the decontamination of a surface comprising:
  • the optional pre-wash/dipping component may comprise a chelating agent.
  • the chelating agent should have an affinity to copper or iron and salts thereof. It will be understood that more than one chelating agent may be present, for example, a copper selective chelating agent may be combined with an iron selective chelating agent.
  • the chelating agent may also be an agent, e.g. an acidulant, which may reduce the pH of the environment, such as, an organic acid selected from one or more of citric acid, lactic acid, succinic acid or tannic acid or a combination thereof, and optionally salts thereof.
  • the chelating agent e.g. in a single composition or solution, or separate.
  • the decontaminant may comprise a combined treatment of an acidulant and an antioxidant/ reducing agent.
  • the acidulant may desirably be a modified acidified salt, such as bisulphate of soda as hereinbefore described. Therefore, the acidulant is selected from those that will reduce the pH to at least about 3 or less.
  • the acidulant will reduce the pH to at least about 2.3 or less, preferably 2 or less, preferably to about 1.8 or less and most preferably to about 1.4 or less.
  • the antioxidant/ reducing agent may preferentially be one or more of ascorbic acid (vitamin C) and especially salts thereof, such as alkali metal salts, e.g. sodium ascorbate; erythorbic acid and especially salts thereof, such as alkali metal salts, e.g.
  • phenolic antioxidant carboxylic acids such as a rosmarinic acid ([[3-(3,4-dihydroxyphenyl)-l-oxo-2E-propenyl]oxy]-3,4-dihydroxy- benzenepropanoic acid) and optionally salts thereof, such as alkali metal salts.
  • the present invention relates to decontamination formulations for disinfection and sterilization applications.
  • the present invention is directed to aqueous formulations that include at least one reactive compound, bleaching activator, and inorganic base; and that allow the formulation to be pre-mixed and packaged as a one or two-part kit system.
  • the decontamination composition can be delivered in a wide variety of embodiments, including, but not limited to, foams, sprays, liquids, gels, fogs, aerosols, etc.
  • composition or kit of the present invention comprises an amount of bisulphate of soda from about 0.5% to about 25% (w/v). In one aspect a method, composition or kit of the present invention comprises an amount of lactic acid from about 0.5% to about 10% (w/v). In one aspect a method, composition or kit of the present invention an amount of erythorbic acid may be from about 0.5% to about 10% (w/v). In one aspect a method, composition or kit of the present invention an amount of sodium erythorbate may be from about 0.5% to about 10% (w/v). In one aspect a method, composition or kit of the present invention an amount of succinic acid may be from about 0.1% to about 2% (w/v).
  • an amount of alkyl (preferably C8) glucoside may be from about 2% to about 10% (w/v).
  • an amount of tannic acid may be from about 1% to about 15% (w/v).
  • an amount of ascorbic acid may be from about 1% to about 20% (w/v).
  • an amount of rosmarinic acid may be from about 0.25% to about 1% (w/v).
  • a method, composition or kit of the present invention comprises an amount of bisulphate of soda from about 0.5% to about 25% (w/v), an amount of lactic acid from about 0.5% to about 10% (w/v), an amount of erythorbic acid from about 0.5% to about 10% (w/v), an amount of sodium erythorbate from about 0.5% to about 10% (w/v), an amount of succinic acid from about 0.1% to about 2% (w/v), an amount of alkyl (preferably C8) glucoside from about 2% to about 10% (w/v), an amount of tannic acid from about 1% to about 15% (w/v), an amount of ascorbic acid from about 1% to about 20% (w/v), and an amount of rosmarinic acid from about 0.25% to about 1% (w/v).
  • the decontamination as hereinbefore described may comprise the removal, elimination, mitigation of prevention of one or more of bacteria, fungi, yeasts and viruses.
  • the decontamination is particularly useful against gram-positive bacteria, which shall include, but shall not be limited to, Staphylococci, such as, S. aureus; Streptococci, such as, S. pyogenes, S 1 . agalactiae, S. pneumonia, etc.; Enterococci, such as, E. faecal is; Corynebacteria, such as, C diphtheriae; Clostridia, such as, C. botulinum; and Listeria, such as, L. monocytogenes; or the decontamination of gram-negative bacteria which shall include, but shall not be limited to, Escherichia coli, Salmonella and Shigella.
  • Staphylococci such as, S. aureus
  • Streptococci such as, S. pyogenes, S
  • Formulation can be (w/v):

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Detergent Compositions (AREA)

Abstract

L'invention concerne une méthode de décontamination d'une surface, la méthode consistant en : (i) une première étape facultative de prélavage de la surface dans une concentration élevée du produit décontaminant pour traiter les épandages importants ; (ii) un lavage de la surface dans une concentration faible du produit décontaminant pour traiter les restes de présence microbienne ; le produit décontaminant contenant un acidulant.
PCT/GB2011/000312 2010-03-05 2011-03-04 Agent antimicrobien WO2011107753A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1003763.8A GB201003763D0 (en) 2010-03-05 2010-03-05 Evaluation of an anti microbial agent
GB1003763.8 2010-03-05

Publications (1)

Publication Number Publication Date
WO2011107753A1 true WO2011107753A1 (fr) 2011-09-09

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ID=42136595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/000312 WO2011107753A1 (fr) 2010-03-05 2011-03-04 Agent antimicrobien

Country Status (2)

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GB (1) GB201003763D0 (fr)
WO (1) WO2011107753A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037172A1 (fr) * 1998-01-21 1999-07-29 Health And Hygiene International Pty. Ltd. Nettoyage de produits frais permettant d'augmenter la duree de conservation
WO2000032052A1 (fr) * 1998-11-25 2000-06-08 Raytec Corporation Methodes et systemes de reduction de microflores
WO2005070205A1 (fr) * 2004-01-09 2005-08-04 Ecolab Inc. Compositions d'acide peroxycarboxylique a chaine moyenne
WO2010139946A2 (fr) * 2009-06-01 2010-12-09 Jeff Dodd Composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037172A1 (fr) * 1998-01-21 1999-07-29 Health And Hygiene International Pty. Ltd. Nettoyage de produits frais permettant d'augmenter la duree de conservation
WO2000032052A1 (fr) * 1998-11-25 2000-06-08 Raytec Corporation Methodes et systemes de reduction de microflores
WO2005070205A1 (fr) * 2004-01-09 2005-08-04 Ecolab Inc. Compositions d'acide peroxycarboxylique a chaine moyenne
WO2010139946A2 (fr) * 2009-06-01 2010-12-09 Jeff Dodd Composition

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Publication number Publication date
GB201003763D0 (en) 2010-04-21

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